CD19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* B cell receptor signaling pathway (GO:0050853)9.09662274
2antigen processing and presentation of endogenous antigen (GO:0019883)7.50464454
3positive regulation of gamma-delta T cell activation (GO:0046645)7.45292214
4regulation of B cell receptor signaling pathway (GO:0050855)6.53317567
5regulation of B cell differentiation (GO:0045577)6.49936530
6positive regulation of B cell differentiation (GO:0045579)6.31751389
7B cell proliferation (GO:0042100)6.10343063
8cellular response to zinc ion (GO:0071294)5.97592831
9regulation of gamma-delta T cell differentiation (GO:0045586)5.72248658
10regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.59779985
11regulation of gamma-delta T cell activation (GO:0046643)5.22317895
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.03667408
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.03667408
14positive thymic T cell selection (GO:0045059)4.96306568
15negative regulation of histone methylation (GO:0031061)4.69085540
16mature B cell differentiation (GO:0002335)4.59786866
17CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.54823076
18regulation of antigen processing and presentation (GO:0002577)4.54546171
19regulation of B cell proliferation (GO:0030888)4.50737713
20negative regulation of B cell proliferation (GO:0030889)4.43445874
21detection of bacterium (GO:0016045)4.37905465
22regulation of interferon-beta biosynthetic process (GO:0045357)4.32770912
23B cell mediated immunity (GO:0019724)4.32393434
24regulation of histone H3-K9 methylation (GO:0051570)4.14806908
25cellular response to interleukin-15 (GO:0071350)4.12544738
26regulation of B cell apoptotic process (GO:0002902)4.12163608
27regulation of superoxide anion generation (GO:0032928)4.12150684
28cytidine metabolic process (GO:0046087)4.12027137
29cytidine catabolic process (GO:0006216)4.12027137
30cytidine deamination (GO:0009972)4.12027137
31type I interferon signaling pathway (GO:0060337)4.08586197
32cellular response to type I interferon (GO:0071357)4.08586197
33response to type I interferon (GO:0034340)4.07668543
34response to interleukin-15 (GO:0070672)4.07320509
35B cell activation (GO:0042113)4.06697732
36detection of other organism (GO:0098543)4.06010016
37* antigen receptor-mediated signaling pathway (GO:0050851)4.05689518
38positive regulation of Rap GTPase activity (GO:0032854)4.02305379
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.01064770
40serine transport (GO:0032329)4.00121538
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.90189854
42B cell homeostasis (GO:0001782)3.83124969
43positive regulation by symbiont of host defense response (GO:0052509)3.80211218
44modulation by symbiont of host defense response (GO:0052031)3.80211218
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80211218
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80211218
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.80211218
48modulation by symbiont of host immune response (GO:0052553)3.80211218
49positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.79518394
50defense response to protozoan (GO:0042832)3.78826443
51regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.76873128
52negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.76389231
53lymphocyte homeostasis (GO:0002260)3.74365676
54positive regulation of B cell proliferation (GO:0030890)3.73829296
55positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.73724871
56regulation of alpha-beta T cell proliferation (GO:0046640)3.73375619
57negative regulation of phagocytosis (GO:0050765)3.73200697
58regulation of interleukin-12 biosynthetic process (GO:0045075)3.70759726
59* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.69149124
60positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.63875855
61T cell selection (GO:0045058)3.62598752
62T cell homeostasis (GO:0043029)3.61943327
63positive regulation of antigen processing and presentation (GO:0002579)3.54765113
64L-serine transport (GO:0015825)3.53219657
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.52509028
66positive regulation of B cell activation (GO:0050871)3.52356408
67thymic T cell selection (GO:0045061)3.52110767
68B cell differentiation (GO:0030183)3.49823347
69negative regulation of B cell apoptotic process (GO:0002903)3.48469605
70production of molecular mediator involved in inflammatory response (GO:0002532)3.47247315
71T cell migration (GO:0072678)3.46773768
72negative thymic T cell selection (GO:0045060)3.44322305
73regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.44230459
74T cell lineage commitment (GO:0002360)3.43571034
75positive regulation of histone deacetylation (GO:0031065)3.43336507
76mononuclear cell proliferation (GO:0032943)3.41203929
77positive T cell selection (GO:0043368)3.40857243
78lymphocyte proliferation (GO:0046651)3.40614099
79negative regulation of bone resorption (GO:0045779)3.40571277
80regulation of B cell activation (GO:0050864)3.39180829
81positive regulation of immunoglobulin production (GO:0002639)3.37686782
82regulation of T-helper 1 cell differentiation (GO:0045625)3.37279353
83immunoglobulin mediated immune response (GO:0016064)3.36737456
84lymph node development (GO:0048535)3.34852466
85germinal center formation (GO:0002467)3.34674796
86regulation of Rap GTPase activity (GO:0032317)3.32831166
87Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.31751104
88immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.31751104
89Fc-gamma receptor signaling pathway (GO:0038094)3.31751104
90mature B cell differentiation involved in immune response (GO:0002313)3.30628342
91neutrophil activation (GO:0042119)3.27619857
92Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.25864703
93positive regulation of type 2 immune response (GO:0002830)3.25317404
94positive regulation of gene expression, epigenetic (GO:0045815)3.22676187
95leukocyte homeostasis (GO:0001776)3.22282231
96positive regulation of cell adhesion mediated by integrin (GO:0033630)3.21636656
97negative regulation of T-helper cell differentiation (GO:0045623)3.20055444
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.20055444
99vesicle targeting (GO:0006903)3.18976545
100negative regulation of alpha-beta T cell activation (GO:0046636)3.15169076
101macrophage activation involved in immune response (GO:0002281)3.14879540
102regulation of germinal center formation (GO:0002634)3.14850729
103response to protozoan (GO:0001562)3.14287436
104regulation of interferon-gamma biosynthetic process (GO:0045072)3.13550724
105positive regulation of humoral immune response (GO:0002922)3.12035043
106negative T cell selection (GO:0043383)3.11404793
107cellular response to interferon-gamma (GO:0071346)3.11067401
108positive regulation of interleukin-2 production (GO:0032743)3.09744941
109regulation of platelet aggregation (GO:0090330)3.08762652
110activation of JUN kinase activity (GO:0007257)3.07009931
111positive regulation of interferon-alpha production (GO:0032727)3.06690545
112regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05277316
113NIK/NF-kappaB signaling (GO:0038061)3.04269500
114leukocyte proliferation (GO:0070661)3.03469362
115V(D)J recombination (GO:0033151)3.02647678
116pyrimidine ribonucleoside catabolic process (GO:0046133)3.01578242
117Peyers patch development (GO:0048541)2.99217904
118mucosal-associated lymphoid tissue development (GO:0048537)2.99217904
119T-helper 1 type immune response (GO:0042088)2.98940087
120leukocyte aggregation (GO:0070486)2.98474949
121T cell costimulation (GO:0031295)2.97878104
122positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.97799620
123interferon-gamma-mediated signaling pathway (GO:0060333)2.97766147
124negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96573966
125negative regulation of cell killing (GO:0031342)2.96573966
126regulation of type I interferon-mediated signaling pathway (GO:0060338)2.95335602
127detection of external biotic stimulus (GO:0098581)2.95054510
128negative regulation of lymphocyte mediated immunity (GO:0002707)2.94526047
129negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.92705708
130respiratory burst (GO:0045730)2.91749549
131lymphocyte costimulation (GO:0031294)2.90439728
132adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.89774616
133antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.89660010
134natural killer cell differentiation (GO:0001779)2.89355433
135regulation of interferon-alpha production (GO:0032647)2.88900572
136granulocyte activation (GO:0036230)2.88704301
137negative regulation of calcium ion transport into cytosol (GO:0010523)2.88561230
138regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.88341825
139regulation of T-helper 2 cell differentiation (GO:0045628)2.88142521
140tolerance induction (GO:0002507)2.87150212
141myeloid dendritic cell activation (GO:0001773)2.87125631
142somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83956451
143somatic hypermutation of immunoglobulin genes (GO:0016446)2.83956451
144humoral immune response (GO:0006959)2.83086324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.72687810
2MYC_22102868_ChIP-Seq_BL_Human5.41126729
3E2F7_22180533_ChIP-Seq_HELA_Human5.12130337
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.46833524
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.24470906
6* SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.13087797
7VDR_21846776_ChIP-Seq_THP-1_Human3.72283512
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.42719324
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.16014867
10* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.12840877
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03563570
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.00236883
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.88742759
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.75235409
15RUNX_20019798_ChIP-Seq_JUKART_Human2.69744242
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.62778074
17MAF_26560356_Chip-Seq_TH1_Human2.54963846
18MYB_26560356_Chip-Seq_TH1_Human2.54491161
19MYB_26560356_Chip-Seq_TH2_Human2.49181838
20UTX_26944678_Chip-Seq_JUKART_Human2.46112926
21CIITA_25753668_ChIP-Seq_RAJI_Human2.44480145
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.37072547
23VDR_24763502_ChIP-Seq_THP-1_Human2.33785978
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31615708
25TCF7_22412390_ChIP-Seq_EML_Mouse2.18161892
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.13947384
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06565468
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06344495
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.02725580
30KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00501826
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96289268
32SPI1_23547873_ChIP-Seq_NB4_Human1.95406612
33KDM2B_26808549_Chip-Seq_DND41_Human1.94697021
34SCL_19346495_ChIP-Seq_HPC-7_Human1.91748480
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90415875
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87407728
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71116510
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67351768
39MAF_26560356_Chip-Seq_TH2_Human1.65550375
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63072795
41* RUNX1_22412390_ChIP-Seq_EML_Mouse1.60248079
42SPI1_23127762_ChIP-Seq_K562_Human1.59451110
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58452116
44GATA1_22025678_ChIP-Seq_K562_Human1.57859278
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52969316
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52813165
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51103113
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49926494
49GATA3_27048872_Chip-Seq_THYMUS_Human1.48691566
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.46508592
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45883940
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44579109
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41707133
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.41310416
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38204145
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38117043
57* ELK3_25401928_ChIP-Seq_HUVEC_Human1.38090254
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36678503
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36252780
60PU.1_20513432_ChIP-Seq_Bcells_Mouse1.35181064
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32509991
62* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28351699
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21345918
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18780981
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12513947
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09397749
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09114433
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07919737
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.07398486
70FOXP3_21729870_ChIP-Seq_TREG_Human1.05630866
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04818408
72PU_27001747_Chip-Seq_BMDM_Mouse1.04405926
73KDM5A_27292631_Chip-Seq_BREAST_Human1.04106054
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00691561
75NCOR1_26117541_ChIP-Seq_K562_Human0.99378473
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98154971
77KDM2B_26808549_Chip-Seq_JURKAT_Human0.96556145
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96546945
79ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95333517
80E2F1_21310950_ChIP-Seq_MCF-7_Human0.94891831
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94793781
82HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94284351
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93713760
84ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90594505
85VDR_24787735_ChIP-Seq_THP-1_Human0.90105477
86GATA3_26560356_Chip-Seq_TH2_Human0.89969157
87P300_27268052_Chip-Seq_Bcells_Human0.88963598
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88552342
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88343588
90* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88060981
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87787039
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87644588
93GATA1_19941827_ChIP-Seq_MEL_Mouse0.84914170
94LXR_22292898_ChIP-Seq_THP-1_Human0.84417852
95VDR_23849224_ChIP-Seq_CD4+_Human0.83950662
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83914766
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80462068
98* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79698772
99GATA3_26560356_Chip-Seq_TH1_Human0.79078215
100BCL6_27268052_Chip-Seq_Bcells_Human0.77467177
101SMRT_27268052_Chip-Seq_Bcells_Human0.77031771
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75188616
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.74747690
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73055808
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72824520
106* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72627176
107SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72132344
108CTCF_27219007_Chip-Seq_ERYTHROID_Human0.71953564
109BCOR_27268052_Chip-Seq_Bcells_Human0.71016549
110TP63_19390658_ChIP-ChIP_HaCaT_Human0.70363365
111SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69629203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.75023866
2* MP0001800_abnormal_humoral_immune5.24028566
3* MP0001790_abnormal_immune_system4.91708382
4* MP0005387_immune_system_phenotype4.91708382
5MP0000685_abnormal_immune_system4.18402829
6* MP0002452_abnormal_antigen_presenting3.86333525
7MP0003303_peritoneal_inflammation3.54997719
8* MP0005000_abnormal_immune_tolerance3.19881653
9* MP0002723_abnormal_immune_serum3.15098516
10* MP0002420_abnormal_adaptive_immunity3.12200891
11* MP0002398_abnormal_bone_marrow3.07498387
12* MP0001819_abnormal_immune_cell3.00059586
13MP0005671_abnormal_response_to2.95910443
14* MP0000716_abnormal_immune_system2.77420435
15* MP0000689_abnormal_spleen_morphology2.75914247
16* MP0002429_abnormal_blood_cell2.26544616
17* MP0002722_abnormal_immune_system2.25741304
18MP0003763_abnormal_thymus_physiology2.24235921
19MP0002396_abnormal_hematopoietic_system2.14096351
20MP0003300_gastrointestinal_ulcer2.06441260
21MP0002166_altered_tumor_susceptibility2.05502166
22MP0004808_abnormal_hematopoietic_stem1.94167015
23* MP0005025_abnormal_response_to1.86324374
24MP0001873_stomach_inflammation1.85594056
25MP0008057_abnormal_DNA_replication1.82610014
26MP0002419_abnormal_innate_immunity1.79777688
27MP0002148_abnormal_hypersensitivity_rea1.74799499
28MP0000703_abnormal_thymus_morphology1.71146852
29MP0002405_respiratory_system_inflammati1.67623172
30MP0003724_increased_susceptibility_to1.67510489
31MP0004510_myositis1.66777424
32MP0003436_decreased_susceptibility_to1.66136843
33MP0010155_abnormal_intestine_physiology1.56200969
34* MP0001845_abnormal_inflammatory_respons1.54586524
35MP0003183_abnormal_peptide_metabolism1.52879515
36MP0001853_heart_inflammation1.52380129
37MP0004947_skin_inflammation1.47973815
38MP0006054_spinal_hemorrhage1.44875768
39MP0010094_abnormal_chromosome_stability1.40034467
40MP0010234_abnormal_vibrissa_follicle1.36947302
41MP0005451_abnormal_body_composition1.35347524
42MP0002006_tumorigenesis1.32366725
43MP0001879_abnormal_lymphatic_vessel1.31894892
44MP0005310_abnormal_salivary_gland1.31726782
45MP0003077_abnormal_cell_cycle1.30096608
46MP0002933_joint_inflammation1.29856694
47MP0003866_abnormal_defecation1.28866232
48MP0003172_abnormal_lysosome_physiology1.22564526
49MP0005464_abnormal_platelet_physiology1.17677646
50MP0005645_abnormal_hypothalamus_physiol1.17639773
51MP0005075_abnormal_melanosome_morpholog1.17518922
52MP0003787_abnormal_imprinting1.14586478
53* MP0009785_altered_susceptibility_to1.14552495
54* MP0002019_abnormal_tumor_incidence1.13067379
55MP0010352_gastrointestinal_tract_polyps1.12932471
56MP0000465_gastrointestinal_hemorrhage1.12350580
57MP0009333_abnormal_splenocyte_physiolog1.11523964
58MP0009278_abnormal_bone_marrow1.07027703
59MP0004381_abnormal_hair_follicle1.03902106
60MP0003091_abnormal_cell_migration1.02056754
61MP0008961_abnormal_basal_metabolism0.97711167
62MP0002132_abnormal_respiratory_system0.96278131
63MP0002909_abnormal_adrenal_gland0.94926950
64* MP0002136_abnormal_kidney_physiology0.90554912
65MP0001348_abnormal_lacrimal_gland0.85093525
66MP0003111_abnormal_nucleus_morphology0.84193082
67MP0005174_abnormal_tail_pigmentation0.84162982
68MP0002928_abnormal_bile_duct0.83108098
69MP0005076_abnormal_cell_differentiation0.82678555
70MP0003045_fibrosis0.82410191
71MP0003693_abnormal_embryo_hatching0.81584175
72MP0000858_altered_metastatic_potential0.81266074
73MP0000569_abnormal_digit_pigmentation0.81219479
74MP0002095_abnormal_skin_pigmentation0.75809347
75MP0000490_abnormal_crypts_of0.74710898
76MP0002139_abnormal_hepatobiliary_system0.71792647
77* MP0008469_abnormal_protein_level0.70812664
78MP0005621_abnormal_cell_physiology0.70731685
79MP0003566_abnormal_cell_adhesion0.70643851
80* MP0000350_abnormal_cell_proliferation0.66541025
81MP0005397_hematopoietic_system_phenotyp0.66368404
82MP0001545_abnormal_hematopoietic_system0.66368404
83MP0006082_CNS_inflammation0.66214974
84MP0002138_abnormal_hepatobiliary_system0.62133373
85MP0001730_embryonic_growth_arrest0.61513958
86MP0000313_abnormal_cell_death0.61407258
87MP0004957_abnormal_blastocyst_morpholog0.59318764
88MP0000015_abnormal_ear_pigmentation0.58211730
89MP0009763_increased_sensitivity_to0.56760979
90MP0000767_abnormal_smooth_muscle0.54583006
91MP0002009_preneoplasia0.54213790
92MP0001663_abnormal_digestive_system0.53627228
93MP0005166_decreased_susceptibility_to0.53098996
94MP0003453_abnormal_keratinocyte_physiol0.52212979
95MP0000609_abnormal_liver_physiology0.52057411
96MP0008877_abnormal_DNA_methylation0.52000958
97MP0001851_eye_inflammation0.50365166
98MP0008058_abnormal_DNA_repair0.50200459
99* MP0000249_abnormal_blood_vessel0.49524190
100MP0002998_abnormal_bone_remodeling0.49315361
101MP0005381_digestive/alimentary_phenotyp0.49041882
102MP0003191_abnormal_cellular_cholesterol0.47396379
103MP0005384_cellular_phenotype0.47180906
104MP0008260_abnormal_autophagy0.46527538
105MP0002163_abnormal_gland_morphology0.46135201
106MP0001784_abnormal_fluid_regulation0.45848850
107MP0003279_aneurysm0.45777607
108MP0000372_irregular_coat_pigmentation0.45734637
109MP0004883_abnormal_blood_vessel0.45529251
110* MP0002083_premature_death0.45162658
111* MP0008874_decreased_physiological_sensi0.44701908
112MP0001986_abnormal_taste_sensitivity0.42913519
113MP0002168_other_aberrant_phenotype0.42173034
114MP0003221_abnormal_cardiomyocyte_apopto0.42063767
115MP0005584_abnormal_enzyme/coenzyme_acti0.41864876
116MP0009115_abnormal_fat_cell0.41724287
117MP0009764_decreased_sensitivity_to0.41248778
118MP0002693_abnormal_pancreas_physiology0.41090723
119MP0000371_diluted_coat_color0.40961517
120MP0000733_abnormal_muscle_development0.40244161
121MP0009931_abnormal_skin_appearance0.40123990
122MP0001533_abnormal_skeleton_physiology0.40090431
123MP0010307_abnormal_tumor_latency0.39915437
124MP0003252_abnormal_bile_duct0.38341836

Predicted human phenotypes

RankGene SetZ-score
1Cellulitis (HP:0100658)7.09100165
2Recurrent bronchitis (HP:0002837)6.72940017
3Verrucae (HP:0200043)6.52435085
4Papilloma (HP:0012740)6.52435085
5Colitis (HP:0002583)6.19967600
6* Gastrointestinal stroma tumor (HP:0100723)6.16432471
7Panhypogammaglobulinemia (HP:0003139)5.27963670
8Inflammation of the large intestine (HP:0002037)5.15751991
9Recurrent viral infections (HP:0004429)5.11424788
10Gastrointestinal inflammation (HP:0004386)5.01579239
11Meningitis (HP:0001287)4.88985730
12Small epiphyses (HP:0010585)4.87883532
13IgM deficiency (HP:0002850)4.87479533
14Chronic sinusitis (HP:0011109)4.83432676
15Abnormality of B cell number (HP:0010975)4.58817186
16B lymphocytopenia (HP:0010976)4.58817186
17Abnormal delayed hypersensitivity skin test (HP:0002963)4.57999251
18* Recurrent sinusitis (HP:0011108)4.44891337
19Osteomyelitis (HP:0002754)4.26143017
20Recurrent pneumonia (HP:0006532)4.07492523
21* Lymphopenia (HP:0001888)4.06100276
22Recurrent lower respiratory tract infections (HP:0002783)3.97795233
23IgA deficiency (HP:0002720)3.97548839
24Thyroiditis (HP:0100646)3.97266117
25* Abnormality of cells of the lymphoid lineage (HP:0012140)3.89312128
26Bronchitis (HP:0012387)3.86046095
27Chronic otitis media (HP:0000389)3.81160538
28* Emphysema (HP:0002097)3.76824604
29Sepsis (HP:0100806)3.71559114
30Mitral stenosis (HP:0001718)3.68665546
31Vertebral arch anomaly (HP:0008438)3.63535510
32Recurrent fungal infections (HP:0002841)3.33075026
33Abnormality of macrophages (HP:0004311)3.29055525
34Hypoplasia of the capital femoral epiphysis (HP:0003090)3.22517909
35* Recurrent otitis media (HP:0000403)3.19663554
36Recurrent cutaneous fungal infections (HP:0011370)3.19106007
37Chronic mucocutaneous candidiasis (HP:0002728)3.19106007
38Abnormality of the fingertips (HP:0001211)3.13709461
39Flattened epiphyses (HP:0003071)3.12962896
40* Vasculitis (HP:0002633)3.08410039
41IgG deficiency (HP:0004315)3.07279131
42Abnormality of the prostate (HP:0008775)3.02069857
43* Restrictive lung disease (HP:0002091)2.95317324
44Recurrent gram-negative bacterial infections (HP:0005420)2.92478518
45Viral hepatitis (HP:0006562)2.92150615
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.85049290
47Recurrent bacterial skin infections (HP:0005406)2.83160743
48Recurrent abscess formation (HP:0002722)2.80286358
49T lymphocytopenia (HP:0005403)2.75853474
50Urticaria (HP:0001025)2.75221881
51Abnormality of T cells (HP:0002843)2.74101276
52Gastrointestinal infarctions (HP:0005244)2.68128611
53Abnormality of T cell number (HP:0011839)2.67825768
54Chronic diarrhea (HP:0002028)2.66602805
55Ulnar bowing (HP:0003031)2.65793941
56Mediastinal lymphadenopathy (HP:0100721)2.61481785
57Abnormality of T cell physiology (HP:0011840)2.61475935
58Skin rash (HP:0000988)2.57361930
59Abnormality of the intervertebral disk (HP:0005108)2.56849408
60Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.56505314
61Absent epiphyses (HP:0010577)2.56505314
62Chest pain (HP:0100749)2.54944243
63Recurrent skin infections (HP:0001581)2.54718076
64Autoimmune thrombocytopenia (HP:0001973)2.54458639
65Irregular vertebral endplates (HP:0003301)2.53796802
66Arthropathy (HP:0003040)2.37314867
67Abnormality of the pleura (HP:0002103)2.35268303
68* Lymphoma (HP:0002665)2.33782326
69Increased IgM level (HP:0003496)2.29889402
70Combined immunodeficiency (HP:0005387)2.26937463
71Skin ulcer (HP:0200042)2.25842262
72Myositis (HP:0100614)2.23200811
73Optic neuritis (HP:0100653)2.23009525
74Retrobulbar optic neuritis (HP:0100654)2.23009525
75Hypertensive crisis (HP:0100735)2.19740373
76* Leukopenia (HP:0001882)2.19398352
77Neutropenia (HP:0001875)2.18354241
78Abnormality of the peritoneum (HP:0002585)2.16714379
79Abnormality of male internal genitalia (HP:0000022)2.13821683
80Encephalitis (HP:0002383)2.12645055
81Severe combined immunodeficiency (HP:0004430)2.10059271
82Hypoplasia of the thymus (HP:0000778)2.08606194
83Gingivitis (HP:0000230)2.08146368
84Orchitis (HP:0100796)2.07900154
85Limited elbow extension (HP:0001377)2.05678871
86Hemoptysis (HP:0002105)2.03206387
87Elevated erythrocyte sedimentation rate (HP:0003565)2.02909817
88Pustule (HP:0200039)2.01951107
89Thrombocytosis (HP:0001894)2.01304237
90Nasal polyposis (HP:0100582)2.01254954
91* Arthralgia (HP:0002829)2.01113225
92Papilledema (HP:0001085)2.00469338
93Agammaglobulinemia (HP:0004432)10.8176698
94Prolonged bleeding time (HP:0003010)1.97084029
95Interstitial pulmonary disease (HP:0006530)1.94859632
96Pulmonary fibrosis (HP:0002206)1.94513107
97Spontaneous hematomas (HP:0007420)1.92637494
98Fatigue (HP:0012378)1.90547508
99Increased IgE level (HP:0003212)1.89246007
100Abnormality of the vertebral endplates (HP:0005106)1.88407844
101Hypergammaglobulinemia (HP:0010702)1.87857385
102Teleangiectasia of the skin (HP:0100585)1.86161420
103Premature loss of primary teeth (HP:0006323)1.86019724
104Chronic obstructive pulmonary disease (HP:0006510)1.83803191
105Obstructive lung disease (HP:0006536)1.83803191
106Eosinophilia (HP:0001880)1.83607058
107Barrel-shaped chest (HP:0001552)1.83072889
108Hematochezia (HP:0002573)1.82991576
109Epistaxis (HP:0000421)1.82495233
110Villous atrophy (HP:0011473)1.80300481
111Abnormality of small intestinal villus morphology (HP:0011472)1.80300481
112Basal cell carcinoma (HP:0002671)1.79770349
113Eczematoid dermatitis (HP:0000976)1.77965177
114Autoimmune hemolytic anemia (HP:0001890)1.77773290
115Dehydration (HP:0001944)1.77685695
116Squamous cell carcinoma (HP:0002860)1.73543165
117Aortic regurgitation (HP:0001659)1.72969723
118Pulmonary embolism (HP:0002204)1.71852187
119Hepatitis (HP:0012115)1.71464609
120Vertebral clefting (HP:0008428)1.71179749
121Long eyelashes (HP:0000527)1.69045745
122Pulmonary infiltrates (HP:0002113)1.66641047
123Facial diplegia (HP:0001349)1.65618027
124Granulocytopenia (HP:0001913)1.63091135
125Abnormality of the nasal mucosa (HP:0000433)1.62439742
126Xerostomia (HP:0000217)1.62126213
127Aplasia/Hypoplasia of the thymus (HP:0010515)1.55255182
128Acrocyanosis (HP:0001063)1.55091559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.70360267
2MAP3K105.31798174
3GRK63.76452071
4ERN13.75032295
5CSF1R2.85062518
6BLK2.83980866
7PRPF4B2.83440241
8SYK2.79371516
9RIPK42.62261692
10SIK22.50590701
11MAP3K132.47050103
12STK102.41767097
13LRRK22.38787718
14EEF2K2.01027520
15SMG11.99889661
16CDK121.88285428
17MAP3K141.79258463
18JAK11.68253151
19TYK21.64830573
20BMPR21.39494146
21* LYN1.37624742
22MARK31.35324666
23HCK1.30703247
24SIK31.30455425
25MST41.30427647
26NME21.24130323
27GRK11.23740682
28PASK1.22243664
29CLK11.18521003
30CSK1.18297823
31EIF2AK31.17485440
32* BTK1.17443595
33BRD41.15159351
34NEK21.14229017
35NEK91.07287359
36ITK1.05934758
37FES1.04858248
38KIT1.04696626
39SIK11.02012565
40PRKCQ0.99868437
41IKBKB0.97767082
42CDK40.97039374
43PRKCH0.95830964
44PIM10.94858540
45CDC42BPA0.94625456
46LCK0.94233327
47TBK10.94229808
48JAK30.92093058
49TRIB30.90738054
50CDK190.90422079
51TNK20.87974623
52IRAK30.84355762
53ZAP700.84077738
54TEC0.83420578
55TXK0.82938493
56PRKD20.78914316
57FGFR30.77267083
58ALK0.76739022
59MATK0.75686726
60MAPK120.74308682
61STK40.73008633
62HIPK20.72295160
63MAPK70.71421684
64TGFBR20.71336862
65WNK10.70617257
66IRAK40.68600768
67PKN20.67398120
68MAP3K70.65966684
69JAK20.65723224
70MELK0.62188221
71CDK90.61763826
72DYRK1B0.60389931
73PRKD10.59429318
74CAMK1G0.55251747
75PDK10.54782277
76TLK10.54126180
77FRK0.54068372
78IRAK20.53807750
79RPS6KA40.52952820
80MAP2K20.52523180
81CHUK0.52445264
82VRK10.50566677
83MAP3K110.49701216
84PDPK10.49200633
85FYN0.47990741
86FGFR40.46069527
87MAPK40.45926126
88RPS6KB20.45398847
89MAP3K10.45187039
90IRAK10.42947719
91MAP3K90.42369652
92MAPK110.42053760
93MAP3K80.41857261
94CAMK1D0.41128258
95IKBKE0.40421323
96TAOK20.39562437
97KSR20.39562251
98CSNK1A1L0.36404815
99TAOK10.36371125
100TAOK30.35957824
101CHEK10.35861332
102CSNK1D0.35508826
103MARK20.34635489
104MAPKAPK20.34443190
105PIK3CG0.33997245
106SGK30.33925970
107MAP2K30.33885104
108FGR0.33055313
109FGFR20.32229585
110EGFR0.32170720
111MAP2K10.31831421
112* ABL10.30925453
113PRKCI0.30824356
114RPS6KA50.30620517
115CDK60.30026308
116PTK60.29093447
117ATR0.27856273
118SCYL20.27535519
119TESK20.27320600
120* INSR0.27232229
121NLK0.26450297
122ICK0.25829462
123CCNB10.25620522
124DYRK30.25542977
125MAPK30.21316438
126CAMKK10.21212544
127YES10.20866948
128ZAK0.20387746

Predicted pathways (KEGG)

RankGene SetZ-score
1* B cell receptor signaling pathway_Homo sapiens_hsa046626.51082208
2* Primary immunodeficiency_Homo sapiens_hsa053406.22043663
3Allograft rejection_Homo sapiens_hsa053304.43876464
4Autoimmune thyroid disease_Homo sapiens_hsa053204.20002889
5Asthma_Homo sapiens_hsa053104.13042077
6Graft-versus-host disease_Homo sapiens_hsa053323.99270642
7Type I diabetes mellitus_Homo sapiens_hsa049403.38812482
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.97325567
9* Hematopoietic cell lineage_Homo sapiens_hsa046402.63583715
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.58076972
11Staphylococcus aureus infection_Homo sapiens_hsa051502.56182798
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.41934525
13Osteoclast differentiation_Homo sapiens_hsa043802.14409770
14Antigen processing and presentation_Homo sapiens_hsa046122.05204457
15Non-homologous end-joining_Homo sapiens_hsa034502.04432876
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.01956658
17Base excision repair_Homo sapiens_hsa034101.93146230
18T cell receptor signaling pathway_Homo sapiens_hsa046601.74681795
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74259076
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.70237284
21Leishmaniasis_Homo sapiens_hsa051401.65762112
22Mismatch repair_Homo sapiens_hsa034301.48962839
23Non-small cell lung cancer_Homo sapiens_hsa052231.48057615
24Chemokine signaling pathway_Homo sapiens_hsa040621.47289398
25Herpes simplex infection_Homo sapiens_hsa051681.46579449
26Tuberculosis_Homo sapiens_hsa051521.35342702
27Measles_Homo sapiens_hsa051621.33523678
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.25730605
29* Epstein-Barr virus infection_Homo sapiens_hsa051691.24794975
30DNA replication_Homo sapiens_hsa030301.24671946
31Chronic myeloid leukemia_Homo sapiens_hsa052201.23103410
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22587172
33Platelet activation_Homo sapiens_hsa046111.21656980
34Rheumatoid arthritis_Homo sapiens_hsa053231.18037503
35Hepatitis B_Homo sapiens_hsa051611.12916095
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09971267
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09799537
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.09161672
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06793498
40Shigellosis_Homo sapiens_hsa051311.05987302
41Pancreatic cancer_Homo sapiens_hsa052121.05893524
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03961612
43Viral carcinogenesis_Homo sapiens_hsa052031.03619223
44Influenza A_Homo sapiens_hsa051640.99175285
45Toxoplasmosis_Homo sapiens_hsa051450.99052759
46Apoptosis_Homo sapiens_hsa042100.97123988
47Acute myeloid leukemia_Homo sapiens_hsa052210.96441651
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.94661815
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91264912
50Lysine degradation_Homo sapiens_hsa003100.91053568
51HTLV-I infection_Homo sapiens_hsa051660.87328581
52Alcoholism_Homo sapiens_hsa050340.81438273
53Viral myocarditis_Homo sapiens_hsa054160.80339688
54Spliceosome_Homo sapiens_hsa030400.79311770
55Phagosome_Homo sapiens_hsa041450.76429399
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75496189
57Glioma_Homo sapiens_hsa052140.74995573
58VEGF signaling pathway_Homo sapiens_hsa043700.74564133
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73299122
60African trypanosomiasis_Homo sapiens_hsa051430.73262898
61Small cell lung cancer_Homo sapiens_hsa052220.72030330
62mTOR signaling pathway_Homo sapiens_hsa041500.70771381
63MicroRNAs in cancer_Homo sapiens_hsa052060.70508563
64FoxO signaling pathway_Homo sapiens_hsa040680.70264806
65Inositol phosphate metabolism_Homo sapiens_hsa005620.66159943
66MAPK signaling pathway_Homo sapiens_hsa040100.64819869
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64367327
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62491432
69Insulin resistance_Homo sapiens_hsa049310.61688329
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61669708
71Homologous recombination_Homo sapiens_hsa034400.61666690
72Ribosome_Homo sapiens_hsa030100.61432314
73Hepatitis C_Homo sapiens_hsa051600.61367334
74mRNA surveillance pathway_Homo sapiens_hsa030150.60978892
75Other glycan degradation_Homo sapiens_hsa005110.59947423
76TNF signaling pathway_Homo sapiens_hsa046680.57784984
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55178315
78Prostate cancer_Homo sapiens_hsa052150.51840773
79p53 signaling pathway_Homo sapiens_hsa041150.51462019
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51170296
81Colorectal cancer_Homo sapiens_hsa052100.51135443
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.50895953
83Notch signaling pathway_Homo sapiens_hsa043300.50696573
84Malaria_Homo sapiens_hsa051440.48076058
85Systemic lupus erythematosus_Homo sapiens_hsa053220.48002038
86Proteoglycans in cancer_Homo sapiens_hsa052050.47111634
87Cell cycle_Homo sapiens_hsa041100.46482101
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46199626
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45243299
90Renal cell carcinoma_Homo sapiens_hsa052110.44952938
91Endocytosis_Homo sapiens_hsa041440.44889864
92Salmonella infection_Homo sapiens_hsa051320.43538259
93Nucleotide excision repair_Homo sapiens_hsa034200.42768077
94Fanconi anemia pathway_Homo sapiens_hsa034600.40700487
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.39929387
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39482234
97Choline metabolism in cancer_Homo sapiens_hsa052310.39231653
98Pertussis_Homo sapiens_hsa051330.36988911
99Long-term potentiation_Homo sapiens_hsa047200.34680533
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34277458
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32916497
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31238311
103Dorso-ventral axis formation_Homo sapiens_hsa043200.30612316
104Type II diabetes mellitus_Homo sapiens_hsa049300.30096392
105Prolactin signaling pathway_Homo sapiens_hsa049170.29845310
106HIF-1 signaling pathway_Homo sapiens_hsa040660.28871932
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27440762
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26709371
109RNA degradation_Homo sapiens_hsa030180.26593667
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26067861
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.25972347
112Glucagon signaling pathway_Homo sapiens_hsa049220.25654236
113ErbB signaling pathway_Homo sapiens_hsa040120.25065910
114Legionellosis_Homo sapiens_hsa051340.22153463
115Endometrial cancer_Homo sapiens_hsa052130.17055593
116GnRH signaling pathway_Homo sapiens_hsa049120.16930590
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.14103464
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10945421
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09368282
120Pentose phosphate pathway_Homo sapiens_hsa000300.07926559
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.06890766
122Fructose and mannose metabolism_Homo sapiens_hsa000510.03262940

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