CD1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.80260945
2virion attachment to host cell (GO:0019062)7.73042959
3adhesion of symbiont to host cell (GO:0044650)7.73042959
4negative thymic T cell selection (GO:0045060)7.65451916
5cellular extravasation (GO:0045123)7.65412119
6adhesion of symbiont to host (GO:0044406)6.71927336
7wound healing, spreading of epidermal cells (GO:0035313)5.91008065
8V(D)J recombination (GO:0033151)5.40688630
9long-chain fatty acid biosynthetic process (GO:0042759)5.39563750
10positive T cell selection (GO:0043368)5.30487124
11T cell selection (GO:0045058)5.28353205
12positive thymic T cell selection (GO:0045059)5.18638451
13thymic T cell selection (GO:0045061)5.16836538
14activated T cell proliferation (GO:0050798)5.12595752
15positive regulation of gamma-delta T cell activation (GO:0046645)5.08710706
16positive regulation of granulocyte differentiation (GO:0030854)4.97358681
17regulation of apoptotic cell clearance (GO:2000425)4.89087436
18regulation of hypersensitivity (GO:0002883)4.81042603
19pinocytosis (GO:0006907)4.66305212
20negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.55647348
21regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)4.53649756
22response to muramyl dipeptide (GO:0032495)4.51592449
23negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.47446024
24lipoxygenase pathway (GO:0019372)4.42653468
25Peyers patch development (GO:0048541)4.41687987
26mucosal-associated lymphoid tissue development (GO:0048537)4.41687987
27wound healing, spreading of cells (GO:0044319)4.27355610
28mannose metabolic process (GO:0006013)4.22605763
29glycosphingolipid catabolic process (GO:0046479)4.18966921
30positive regulation of mast cell activation (GO:0033005)4.17841126
31regulation of gamma-delta T cell differentiation (GO:0045586)4.16207673
32regulation of interleukin-2 biosynthetic process (GO:0045076)4.14538950
33positive regulation of B cell differentiation (GO:0045579)4.12408008
34regulation of granulocyte differentiation (GO:0030852)4.04245138
35homeostasis of number of cells within a tissue (GO:0048873)3.91172580
36negative regulation of thymocyte apoptotic process (GO:0070244)3.88396267
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.83072246
38negative regulation of adaptive immune response (GO:0002820)3.77318095
39glycolipid catabolic process (GO:0019377)3.74791115
40negative regulation of myotube differentiation (GO:0010832)3.72206523
41leukocyte migration involved in inflammatory response (GO:0002523)3.71424070
42regulation of interleukin-4 production (GO:0032673)3.71367556
43regulation of gamma-delta T cell activation (GO:0046643)3.69070196
44apoptotic cell clearance (GO:0043277)3.58359117
45positive regulation of mast cell degranulation (GO:0043306)3.54533469
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.54533469
47T cell costimulation (GO:0031295)3.51036884
48modulation by virus of host morphology or physiology (GO:0019048)3.49750492
49regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.47378760
50lymphocyte costimulation (GO:0031294)3.47090396
51immunoglobulin mediated immune response (GO:0016064)3.42881154
52negative regulation of B cell apoptotic process (GO:0002903)3.35074426
53ceramide catabolic process (GO:0046514)3.32356188
54apoptotic process involved in morphogenesis (GO:0060561)3.32179180
55developmental pigmentation (GO:0048066)3.29170352
56granulocyte differentiation (GO:0030851)3.26513461
57negative regulation of granulocyte differentiation (GO:0030853)3.24631518
58phosphatidylethanolamine biosynthetic process (GO:0006646)3.23732894
59negative regulation of T cell mediated immunity (GO:0002710)3.19961798
60regulation of mast cell activation (GO:0033003)3.19331847
61regulation of transforming growth factor beta1 production (GO:0032908)3.19295644
62positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.14049962
63membrane lipid catabolic process (GO:0046466)3.12849631
64response to peptidoglycan (GO:0032494)3.10515310
65positive regulation of antigen processing and presentation (GO:0002579)3.10335843
66sphingolipid catabolic process (GO:0030149)3.08076572
67epithelial cell differentiation involved in prostate gland development (GO:0060742)3.05895458
68regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.02490607
69receptor guanylyl cyclase signaling pathway (GO:0007168)3.02383511
70positive regulation of alpha-beta T cell differentiation (GO:0046638)3.01850455
71myeloid dendritic cell activation (GO:0001773)3.00974544
72leukocyte cell-cell adhesion (GO:0007159)2.99078442
73regulation of mast cell degranulation (GO:0043304)2.96973214
74positive regulation of cellular amide metabolic process (GO:0034250)2.96278689
75positive regulation by host of viral transcription (GO:0043923)2.94928056
76phosphatidylethanolamine metabolic process (GO:0046337)2.94559337
77positive regulation of calcium-mediated signaling (GO:0050850)2.92042663
78negative regulation of type 2 immune response (GO:0002829)2.91896823
79chaperone mediated protein folding requiring cofactor (GO:0051085)2.90775228
80histamine secretion (GO:0001821)2.89252669
81myeloid cell development (GO:0061515)2.88042222
82regulation of T-helper 2 cell differentiation (GO:0045628)2.87227264
83hematopoietic stem cell differentiation (GO:0060218)2.85451997
84protein localization to microtubule (GO:0035372)2.84666523
85radial glial cell differentiation (GO:0060019)2.82977937
86positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.82523902
87regulation of receptor binding (GO:1900120)2.81969304
88regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.81766950
89T-helper 1 type immune response (GO:0042088)2.80928422
90membrane raft organization (GO:0031579)2.80880702
91myeloid dendritic cell differentiation (GO:0043011)2.80281214
92nerve growth factor signaling pathway (GO:0038180)2.79883460
93T cell activation involved in immune response (GO:0002286)2.79838012
94macrophage differentiation (GO:0030225)2.78049126
95regulation of alpha-beta T cell differentiation (GO:0046637)2.77925849
96positive regulation of macrophage cytokine production (GO:0060907)2.76840781
97positive regulation of keratinocyte differentiation (GO:0045618)2.76560532
98regulation of inflammatory response to antigenic stimulus (GO:0002861)2.73298554
99regulation of mast cell activation involved in immune response (GO:0033006)2.73084372
100cellular response to interleukin-4 (GO:0071353)2.72731357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.51739272
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.78083618
3E2F7_22180533_ChIP-Seq_HELA_Human4.49487534
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.98062891
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.52226766
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.41289716
7SCL_19346495_ChIP-Seq_HPC-7_Human3.35127175
8RUNX_20019798_ChIP-Seq_JUKART_Human3.32051848
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07659873
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04790530
11MYC_22102868_ChIP-Seq_BL_Human2.97749626
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.95185878
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.86607680
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.73917274
15VDR_21846776_ChIP-Seq_THP-1_Human2.71814946
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.56165793
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46750489
18* GATA3_27048872_Chip-Seq_THYMUS_Human2.43001717
19SPI1_23127762_ChIP-Seq_K562_Human2.41651658
20MYB_26560356_Chip-Seq_TH2_Human2.38496732
21VDR_24763502_ChIP-Seq_THP-1_Human2.37216294
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30633781
23SPI1_23547873_ChIP-Seq_NB4_Human2.25836631
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.12574598
25* UTX_26944678_Chip-Seq_JUKART_Human2.12568743
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.10957519
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08044583
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07219691
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01681655
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00615132
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99942662
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96640124
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78318640
34TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.78002454
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.73341699
36TCF7_22412390_ChIP-Seq_EML_Mouse1.72297803
37MAF_26560356_Chip-Seq_TH1_Human1.71575441
38VDR_24787735_ChIP-Seq_THP-1_Human1.71443703
39* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71266093
40MYB_26560356_Chip-Seq_TH1_Human1.70690655
41CIITA_25753668_ChIP-Seq_RAJI_Human1.70042336
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67945269
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63836166
44MAF_26560356_Chip-Seq_TH2_Human1.63628441
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61521964
46KDM2B_26808549_Chip-Seq_DND41_Human1.61264298
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59815823
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57271802
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53761748
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53461296
51PU_27001747_Chip-Seq_BMDM_Mouse1.53260087
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53106553
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52441316
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48486024
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47944331
56* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.47786413
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44333537
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41688008
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41616538
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41452680
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.37954149
62GATA1_19941826_ChIP-Seq_K562_Human1.37407288
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36857511
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35103169
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30182843
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29434672
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29205860
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25367046
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.21748767
70LXR_22292898_ChIP-Seq_THP-1_Human1.21359408
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.19362639
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18083978
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17726197
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.15150943
75EGR1_19032775_ChIP-ChIP_M12_Human1.14155055
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11592228
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.11333269
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06360914
79TFEB_21752829_ChIP-Seq_HELA_Human1.03479919
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02820155
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01847798
82GATA1_22025678_ChIP-Seq_K562_Human1.01143542
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00521828
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98574876
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98086955
86GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96995826
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96350431
88CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95048651
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94162840
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93634924
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93564971
92ELK3_25401928_ChIP-Seq_HUVEC_Human0.93375114
93NCOR1_26117541_ChIP-Seq_K562_Human0.92801122
94GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92413424
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88225455
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87061248
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86666653
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86542150
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85095164
100GATA2_19941826_ChIP-Seq_K562_Human0.84842079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.93570911
2MP0000569_abnormal_digit_pigmentation3.48565683
3MP0004381_abnormal_hair_follicle3.37288259
4MP0003279_aneurysm3.35294286
5MP0003172_abnormal_lysosome_physiology3.30006341
6MP0001958_emphysema3.24344792
7MP0002396_abnormal_hematopoietic_system2.74432351
8MP0002148_abnormal_hypersensitivity_rea2.69442117
9MP0004947_skin_inflammation2.55490377
10MP0008004_abnormal_stomach_pH2.55479621
11MP0001835_abnormal_antigen_presentation2.47283155
12MP0005058_abnormal_lysosome_morphology2.39347007
13MP0000015_abnormal_ear_pigmentation2.35969683
14MP0003763_abnormal_thymus_physiology2.35561529
15MP0001790_abnormal_immune_system2.35365861
16MP0005387_immune_system_phenotype2.35365861
17MP0002405_respiratory_system_inflammati2.34533525
18MP0003705_abnormal_hypodermis_morpholog2.27743699
19MP0003300_gastrointestinal_ulcer2.15237826
20MP0005647_abnormal_sex_gland2.07146816
21MP0002419_abnormal_innate_immunity2.07071918
22MP0005025_abnormal_response_to2.04850320
23MP0005075_abnormal_melanosome_morpholog2.04788548
24MP0000685_abnormal_immune_system1.95573543
25MP0002452_abnormal_antigen_presenting1.79706305
26MP0005451_abnormal_body_composition1.74379976
27MP0002420_abnormal_adaptive_immunity1.71247764
28MP0001819_abnormal_immune_cell1.71075158
29MP0005174_abnormal_tail_pigmentation1.69345163
30MP0005166_decreased_susceptibility_to1.67380041
31MP0001849_ear_inflammation1.65220461
32MP0002398_abnormal_bone_marrow1.65203996
33MP0001853_heart_inflammation1.64444043
34MP0005000_abnormal_immune_tolerance1.62952212
35MP0005464_abnormal_platelet_physiology1.61844995
36MP0009115_abnormal_fat_cell1.61791220
37MP0001800_abnormal_humoral_immune1.61780351
38MP0001727_abnormal_embryo_implantation1.59856462
39MP0001545_abnormal_hematopoietic_system1.54936752
40MP0005397_hematopoietic_system_phenotyp1.54936752
41MP0003436_decreased_susceptibility_to1.54784194
42MP0000703_abnormal_thymus_morphology1.54716578
43MP0002971_abnormal_brown_adipose1.53374729
44MP0000716_abnormal_immune_system1.50519530
45MP0002723_abnormal_immune_serum1.50504404
46MP0004084_abnormal_cardiac_muscle1.48142962
47MP0002722_abnormal_immune_system1.46354057
48MP0002877_abnormal_melanocyte_morpholog1.45281078
49MP0004185_abnormal_adipocyte_glucose1.42359117
50MP0003075_altered_response_to1.39948675
51MP0000343_altered_response_to1.37460149
52MP0010307_abnormal_tumor_latency1.36408758
53MP0005670_abnormal_white_adipose1.33659853
54MP0000371_diluted_coat_color1.32380982
55MP0000689_abnormal_spleen_morphology1.29819928
56MP0006082_CNS_inflammation1.23054419
57MP0002429_abnormal_blood_cell1.22605600
58MP0002166_altered_tumor_susceptibility1.22054602
59MP0003566_abnormal_cell_adhesion1.21038726
60MP0004264_abnormal_extraembryonic_tissu1.20365917
61MP0001986_abnormal_taste_sensitivity1.19133971
62MP0003303_peritoneal_inflammation1.12962649
63MP0005409_darkened_coat_color1.10333017
64MP0008057_abnormal_DNA_replication1.07907879
65MP0000920_abnormal_myelination1.05647994
66MP0004808_abnormal_hematopoietic_stem1.03612256
67MP0001845_abnormal_inflammatory_respons1.03141738
68MP0009278_abnormal_bone_marrow1.01993396
69MP0002970_abnormal_white_adipose0.99198903
70MP0002009_preneoplasia0.96777235
71MP0005310_abnormal_salivary_gland0.96584063
72MP0004036_abnormal_muscle_relaxation0.95641303
73MP0000858_altered_metastatic_potential0.93461262
74MP0003828_pulmonary_edema0.92578686
75MP0002998_abnormal_bone_remodeling0.92203324
76MP0002075_abnormal_coat/hair_pigmentati0.88512556
77MP0003448_altered_tumor_morphology0.86162419
78MP0004742_abnormal_vestibular_system0.86099322
79MP0010234_abnormal_vibrissa_follicle0.84357671
80MP0003724_increased_susceptibility_to0.82525100
81MP0009333_abnormal_splenocyte_physiolog0.82463463
82MP0005666_abnormal_adipose_tissue0.81930792
83MP0000604_amyloidosis0.79640715
84MP0009785_altered_susceptibility_to0.78397393
85MP0001533_abnormal_skeleton_physiology0.76195729
86MP0001851_eye_inflammation0.75848995
87MP0010094_abnormal_chromosome_stability0.74103269
88MP0003091_abnormal_cell_migration0.73086576
89MP0000639_abnormal_adrenal_gland0.70427507
90MP0009697_abnormal_copulation0.68663786
91MP0010155_abnormal_intestine_physiology0.67553817
92MP0008469_abnormal_protein_level0.67184306
93MP0000627_abnormal_mammary_gland0.66514631
94MP0006138_congestive_heart_failure0.66305974
95MP0002019_abnormal_tumor_incidence0.65627467
96MP0008874_decreased_physiological_sensi0.64864227
97MP0005334_abnormal_fat_pad0.64007895
98MP0001186_pigmentation_phenotype0.62246655
99MP0010352_gastrointestinal_tract_polyps0.60434654
100MP0005076_abnormal_cell_differentiation0.57775100

Predicted human phenotypes

RankGene SetZ-score
1Esophageal varix (HP:0002040)5.83518606
2Systemic lupus erythematosus (HP:0002725)5.41814497
3Abnormality of macrophages (HP:0004311)5.14167633
4Chronic mucocutaneous candidiasis (HP:0002728)4.95544379
5Recurrent cutaneous fungal infections (HP:0011370)4.95544379
6Protuberant abdomen (HP:0001538)4.70571001
7Panhypogammaglobulinemia (HP:0003139)4.13543110
8Recurrent fungal infections (HP:0002841)4.06771882
9B lymphocytopenia (HP:0010976)3.85927278
10Increased cerebral lipofuscin (HP:0011813)3.82453299
11Steatorrhea (HP:0002570)3.75907886
12Abnormality of liposaccharide metabolism (HP:0010968)3.75189552
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.75189552
14Abnormality of glycolipid metabolism (HP:0010969)3.75189552
15Severe combined immunodeficiency (HP:0004430)3.67844510
16Combined immunodeficiency (HP:0005387)3.63030805
17Recurrent abscess formation (HP:0002722)3.48103434
18Recurrent bacterial skin infections (HP:0005406)3.46866740
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.43874022
20Hypercholesterolemia (HP:0003124)3.43428443
21Hepatosplenomegaly (HP:0001433)3.42267295
22Multiple lipomas (HP:0001012)3.38684163
23Upper motor neuron abnormality (HP:0002127)3.37774289
24Abnormality of B cell number (HP:0010975)3.35627527
25Broad face (HP:0000283)3.35586117
26Recurrent skin infections (HP:0001581)3.35188618
27Spontaneous hematomas (HP:0007420)3.35157927
28Hypoplasia of the thymus (HP:0000778)3.17488858
29Polygenic inheritance (HP:0010982)3.07125247
30Cortical dysplasia (HP:0002539)3.02459598
31Recurrent viral infections (HP:0004429)2.93117462
32Loss of speech (HP:0002371)2.89998027
33Flat cornea (HP:0007720)2.85442306
34Adactyly (HP:0009776)2.84302152
35Axonal loss (HP:0003447)2.83350872
36Meningitis (HP:0001287)2.82356647
37Thoracic kyphosis (HP:0002942)2.68372492
38Thyroiditis (HP:0100646)2.63568142
39Subaortic stenosis (HP:0001682)2.63504838
40Abnormality of the left ventricular outflow tract (HP:0011103)2.63504838
41Dysostosis multiplex (HP:0000943)2.62598945
42Amaurosis fugax (HP:0100576)2.57796517
43Fat malabsorption (HP:0002630)2.57186592
44Autoimmune thrombocytopenia (HP:0001973)2.55524009
45Increased IgE level (HP:0003212)2.54277591
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.53921628
47Colitis (HP:0002583)2.53430153
48Mutism (HP:0002300)2.43183013
49Aplasia cutis congenita (HP:0001057)2.42283485
50Disinhibition (HP:0000734)2.40805650
51T lymphocytopenia (HP:0005403)2.39542046
52Abdominal distention (HP:0003270)2.37735352
53Supernumerary nipples (HP:0002558)2.37689621
54Eczematoid dermatitis (HP:0000976)2.36877006
55Agnosia (HP:0010524)2.34343866
56Hyperacusis (HP:0010780)2.29422339
57Segmental peripheral demyelination/remyelination (HP:0003481)2.27748433
58Personality changes (HP:0000751)2.27610306
59Viral hepatitis (HP:0006562)2.26483199
60Granulocytopenia (HP:0001913)2.26033534
61Albinism (HP:0001022)2.19982392
62Cheilitis (HP:0100825)2.18361122
63Gastrointestinal inflammation (HP:0004386)2.16129145
64Absent hand (HP:0004050)2.15793015
65Inflammation of the large intestine (HP:0002037)2.14574221
66Eosinophilia (HP:0001880)2.13742548
67Scanning speech (HP:0002168)2.06244289
68Acute myeloid leukemia (HP:0004808)2.04828614
69Abnormality of the right ventricle (HP:0001707)2.04198339
70Peripheral hypomyelination (HP:0007182)2.03570030
71Abnormality of the lumbar spine (HP:0100712)2.02953196
72Vacuolated lymphocytes (HP:0001922)11.6090353
73Mucosal telangiectasiae (HP:0100579)1.98981783
74Abnormality of the thoracic spine (HP:0100711)1.98341679
75Hemoptysis (HP:0002105)1.95145532
76Abnormality of the columella (HP:0009929)1.94176844
77Abnormality of the prostate (HP:0008775)1.93957657
78Skull defect (HP:0001362)1.93674302
79Mediastinal lymphadenopathy (HP:0100721)1.91897819
80Hematochezia (HP:0002573)1.91781408
81Apathy (HP:0000741)1.91663341
82Leukocytosis (HP:0001974)1.89480213
83Obstructive lung disease (HP:0006536)1.89373709
84Chronic obstructive pulmonary disease (HP:0006510)1.89373709
85Abnormality of T cell number (HP:0011839)1.88782628
86Diminished motivation (HP:0000745)1.86621278
87Ascites (HP:0001541)1.86109143
88Hypertensive crisis (HP:0100735)1.84716148
89Aplasia/Hypoplasia of the thymus (HP:0010515)1.84030476
90Cutis marmorata (HP:0000965)1.83176465
91Flat occiput (HP:0005469)1.82608040
92Neuronal loss in central nervous system (HP:0002529)1.82017970
93Pruritus (HP:0000989)1.76779073
94Progressive visual loss (HP:0000529)1.76592978
95Thin bony cortex (HP:0002753)1.75805009
96Pulmonary hypertension (HP:0002092)1.75712361
97Pustule (HP:0200039)1.75317830
98Distal lower limb muscle weakness (HP:0009053)1.74472937
99Cardiomegaly (HP:0001640)1.72936123
100Agammaglobulinemia (HP:0004432)1.72530306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.16553145
2CDK123.38225750
3NLK3.30810270
4PRPF4B3.24805195
5SMG13.05437275
6CAMKK22.55341809
7NEK92.51885482
8MAP3K142.39555366
9TTN2.29605656
10MAP3K132.26747441
11TYK22.26706942
12CDK62.16773530
13TAF12.16677180
14MAP3K101.97794901
15CAMK1D1.93067519
16CAMKK11.90389594
17ITK1.84875454
18CSF1R1.82607965
19CDC42BPA1.76171866
20PIK3CG1.75468953
21BTK1.69337096
22TRIB31.66145067
23FES1.65861927
24BRD41.64313095
25CAMK1G1.63153931
26RIPK41.63143118
27ZAP701.58287201
28GRK71.55516403
29CSK1.51627182
30ICK1.43588578
31JAK31.40732385
32SYK1.39837687
33MAP4K11.29255974
34KSR21.27864118
35MAP3K21.27504783
36MARK21.24336361
37CAMK41.22923591
38EEF2K1.22271824
39PRKCQ1.21573682
40VRK11.10998669
41HCK1.09602445
42CDK41.08409802
43DAPK31.07203108
44RPS6KA21.05582228
45SCYL21.01004125
46CDK70.95793680
47MAP3K80.93688742
48LCK0.85517405
49SGK30.80853449
50JAK20.80601626
51MAP3K70.77999394
52RPS6KC10.77869604
53RPS6KL10.77869604
54LIMK10.77181327
55PIM20.75546643
56MAPK110.75359537
57TESK20.73983168
58MAPK120.73793127
59YES10.70757114
60LYN0.67106461
61PKN20.66701965
62TEC0.64641666
63VRK20.64046303
64CDK90.63907311
65MELK0.62719343
66TRPM70.62111021
67PDK10.61487570
68ARAF0.59618631
69MOS0.59251856
70RPS6KA60.58997393
71MAP3K10.58682229
72RAF10.56463318
73FGR0.56297014
74MAPKAPK50.56245055
75TLK10.54041442
76DAPK20.53103783
77MAP3K60.52608655
78PDPK10.51930851
79DAPK10.50946760
80SGK20.50929821
81CAMK10.49586723
82JAK10.48812789
83RET0.47917955
84HIPK20.46286845
85ADRBK20.44201406
86MAPKAPK20.42900650
87ZAK0.41346002
88MTOR0.39479682
89STK40.35419496
90WNK10.34792956
91MAPK40.34385264
92FYN0.33236587
93PDGFRB0.31401849
94KSR10.30569178
95CDK140.30177952
96MAP3K50.30072392
97MAPK70.27547452
98MAPK30.27462887
99RPS6KA10.26561117
100MAP3K30.23554880

Predicted pathways (KEGG)

RankGene SetZ-score
1* Hematopoietic cell lineage_Homo sapiens_hsa046404.64848425
2Steroid biosynthesis_Homo sapiens_hsa001002.99728131
3Staphylococcus aureus infection_Homo sapiens_hsa051502.99437131
4Asthma_Homo sapiens_hsa053102.68016075
5Systemic lupus erythematosus_Homo sapiens_hsa053222.61546150
6Allograft rejection_Homo sapiens_hsa053302.50886082
7Leishmaniasis_Homo sapiens_hsa051402.44008574
8Tuberculosis_Homo sapiens_hsa051522.40996957
9Autoimmune thyroid disease_Homo sapiens_hsa053202.37222649
10Primary immunodeficiency_Homo sapiens_hsa053402.33604088
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.31661829
12Lysosome_Homo sapiens_hsa041422.22054785
13Other glycan degradation_Homo sapiens_hsa005112.06662144
14Graft-versus-host disease_Homo sapiens_hsa053322.04138780
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03713583
16Acute myeloid leukemia_Homo sapiens_hsa052211.93258960
17Thyroid cancer_Homo sapiens_hsa052161.92264966
18Phagosome_Homo sapiens_hsa041451.70900049
19Viral myocarditis_Homo sapiens_hsa054161.68513118
20Type I diabetes mellitus_Homo sapiens_hsa049401.65695336
21Non-small cell lung cancer_Homo sapiens_hsa052231.56272663
22Osteoclast differentiation_Homo sapiens_hsa043801.52613681
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48534158
24B cell receptor signaling pathway_Homo sapiens_hsa046621.45656775
25Antigen processing and presentation_Homo sapiens_hsa046121.44839811
26Alcoholism_Homo sapiens_hsa050341.40039029
27Chronic myeloid leukemia_Homo sapiens_hsa052201.35137411
28T cell receptor signaling pathway_Homo sapiens_hsa046601.33264013
29Endometrial cancer_Homo sapiens_hsa052131.31724356
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30366685
31Chemokine signaling pathway_Homo sapiens_hsa040621.29338114
32Viral carcinogenesis_Homo sapiens_hsa052031.27407180
33Notch signaling pathway_Homo sapiens_hsa043301.21463477
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20403023
35Rheumatoid arthritis_Homo sapiens_hsa053231.19408668
36Measles_Homo sapiens_hsa051621.19102514
37Pancreatic cancer_Homo sapiens_hsa052121.12450647
38Toxoplasmosis_Homo sapiens_hsa051451.12383265
39Pentose phosphate pathway_Homo sapiens_hsa000301.08022330
40Colorectal cancer_Homo sapiens_hsa052101.03653620
41Glioma_Homo sapiens_hsa052140.97960873
42Glycosaminoglycan degradation_Homo sapiens_hsa005310.96892515
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95789713
44Prostate cancer_Homo sapiens_hsa052150.93219311
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92493653
46Influenza A_Homo sapiens_hsa051640.87583315
47Epstein-Barr virus infection_Homo sapiens_hsa051690.87183915
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85157947
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83316431
50HTLV-I infection_Homo sapiens_hsa051660.79788236
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.77595574
52Hepatitis B_Homo sapiens_hsa051610.76590578
53Pertussis_Homo sapiens_hsa051330.75922211
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75094026
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73567515
56Linoleic acid metabolism_Homo sapiens_hsa005910.73467532
57Renal cell carcinoma_Homo sapiens_hsa052110.72886144
58Dorso-ventral axis formation_Homo sapiens_hsa043200.65279016
59Herpes simplex infection_Homo sapiens_hsa051680.62912337
60Platelet activation_Homo sapiens_hsa046110.62571402
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.61412591
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.61198606
63Amoebiasis_Homo sapiens_hsa051460.60866048
64Shigellosis_Homo sapiens_hsa051310.57804997
65Legionellosis_Homo sapiens_hsa051340.57608183
66Cell cycle_Homo sapiens_hsa041100.56963626
67Galactose metabolism_Homo sapiens_hsa000520.55466221
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55375701
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53687455
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53164962
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52465975
72Apoptosis_Homo sapiens_hsa042100.52388441
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.51430433
74Renin secretion_Homo sapiens_hsa049240.50708720
75Prolactin signaling pathway_Homo sapiens_hsa049170.49777584
76Adherens junction_Homo sapiens_hsa045200.49071609
77Inositol phosphate metabolism_Homo sapiens_hsa005620.48924824
78MicroRNAs in cancer_Homo sapiens_hsa052060.48719815
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48595916
80Bladder cancer_Homo sapiens_hsa052190.48417327
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47715401
82Prion diseases_Homo sapiens_hsa050200.46780678
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45922720
84Complement and coagulation cascades_Homo sapiens_hsa046100.45122940
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45019186
86Fatty acid elongation_Homo sapiens_hsa000620.43775213
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43565173
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40012372
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.39638153
90DNA replication_Homo sapiens_hsa030300.37086413
91Melanoma_Homo sapiens_hsa052180.35176600
92Salmonella infection_Homo sapiens_hsa051320.34840098
93mTOR signaling pathway_Homo sapiens_hsa041500.34767523
94VEGF signaling pathway_Homo sapiens_hsa043700.32113759
95Type II diabetes mellitus_Homo sapiens_hsa049300.31796914
96Estrogen signaling pathway_Homo sapiens_hsa049150.31490591
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.30509943
98Base excision repair_Homo sapiens_hsa034100.30353110
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.30342873
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30106673

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