CD1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.27590191
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.13921101
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.10520642
4negative regulation of cell killing (GO:0031342)6.10520642
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.05608031
6positive regulation by organism of defense response of other organism involved in symbiotic interact6.05608031
7modulation by symbiont of host immune response (GO:0052553)6.05608031
8positive regulation by symbiont of host defense response (GO:0052509)6.05608031
9modulation by symbiont of host defense response (GO:0052031)6.05608031
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.05608031
11neutrophil activation involved in immune response (GO:0002283)5.86455392
12response to peptidoglycan (GO:0032494)5.46976237
13macrophage activation involved in immune response (GO:0002281)5.12899849
14* detection of other organism (GO:0098543)5.12255796
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.94862928
16regulation of B cell receptor signaling pathway (GO:0050855)4.94121624
17* antigen processing and presentation of endogenous antigen (GO:0019883)4.82600801
18* detection of bacterium (GO:0016045)4.77557881
19cellular extravasation (GO:0045123)4.52947351
20detection of molecule of bacterial origin (GO:0032490)4.49339829
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.48558516
22regulation of gamma-delta T cell activation (GO:0046643)4.46748363
23negative regulation of interleukin-12 production (GO:0032695)4.43934540
24leukocyte aggregation (GO:0070486)4.37458643
25immunoglobulin mediated immune response (GO:0016064)4.36185163
26* detection of external biotic stimulus (GO:0098581)4.30869291
27microglial cell activation (GO:0001774)4.27705697
28respiratory burst (GO:0045730)4.23751608
29positive regulation of mast cell activation (GO:0033005)4.23155278
30regulation of mast cell degranulation (GO:0043304)4.21263374
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.20072270
32regulation of interferon-beta biosynthetic process (GO:0045357)4.18164533
33neutrophil activation (GO:0042119)4.16816263
34response to host immune response (GO:0052572)4.01924597
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.01924597
36leukocyte migration involved in inflammatory response (GO:0002523)4.01036184
37positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.98269962
38regulation of myeloid leukocyte mediated immunity (GO:0002886)3.90867001
39* detection of biotic stimulus (GO:0009595)3.89480688
40myeloid cell activation involved in immune response (GO:0002275)3.88708074
41regulation of mast cell activation involved in immune response (GO:0033006)3.88297859
42macrophage activation (GO:0042116)3.87171379
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81620324
44regulation of mast cell activation (GO:0033003)3.81146099
45response to muramyl dipeptide (GO:0032495)3.76726234
46neutrophil mediated immunity (GO:0002446)3.76088327
47negative regulation of T cell mediated immunity (GO:0002710)3.75682097
48granulocyte activation (GO:0036230)3.74305909
49positive regulation of mast cell degranulation (GO:0043306)3.73326702
50positive regulation of mast cell activation involved in immune response (GO:0033008)3.73326702
51negative regulation of leukocyte mediated immunity (GO:0002704)3.72507705
52regulation of leukocyte degranulation (GO:0043300)3.72021662
53response to host (GO:0075136)3.70856309
54response to host defenses (GO:0052200)3.70856309
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.70856309
56regulation of gamma-delta T cell differentiation (GO:0045586)3.69954487
57B cell receptor signaling pathway (GO:0050853)3.64009443
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.57668335
59negative regulation of erythrocyte differentiation (GO:0045647)3.57319544
60regulation of tolerance induction (GO:0002643)3.52846173
61positive regulation of B cell differentiation (GO:0045579)3.52220203
62positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.49788926
63B cell mediated immunity (GO:0019724)3.43502464
64regulation of B cell differentiation (GO:0045577)3.42564202
65production of molecular mediator involved in inflammatory response (GO:0002532)3.40385018
66positive thymic T cell selection (GO:0045059)3.37014929
67regulation of T cell tolerance induction (GO:0002664)3.33414341
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.26670354
69positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.21569287
70negative regulation of phagocytosis (GO:0050765)3.21437293
71regulation of regulated secretory pathway (GO:1903305)3.20763522
72myeloid leukocyte mediated immunity (GO:0002444)3.20640301
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19410567
74interferon-gamma-mediated signaling pathway (GO:0060333)3.19123043
75leukocyte degranulation (GO:0043299)3.15462716
76positive regulation of cellular amide metabolic process (GO:0034250)3.14407234
77negative thymic T cell selection (GO:0045060)3.14348180
78activated T cell proliferation (GO:0050798)3.11559297
79regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.08703364
80defense response to protozoan (GO:0042832)3.08250428
81negative T cell selection (GO:0043383)3.08025782
82regulation of antigen processing and presentation (GO:0002577)3.07876622
83response to interleukin-15 (GO:0070672)3.06837622
84regulation of alpha-beta T cell proliferation (GO:0046640)3.05740502
85dendritic cell migration (GO:0036336)2.99461009
86positive regulation of antigen processing and presentation (GO:0002579)2.97293339
87type I interferon signaling pathway (GO:0060337)2.94996776
88cellular response to type I interferon (GO:0071357)2.94996776
89positive regulation of tolerance induction (GO:0002645)2.92802993
90response to type I interferon (GO:0034340)2.91575315
91myeloid leukocyte activation (GO:0002274)2.88868234
92regulation of macrophage cytokine production (GO:0010935)2.88081620
93negative regulation of innate immune response (GO:0045824)2.87793786
94positive regulation of interferon-alpha production (GO:0032727)2.86966432
95lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86305526
96positive T cell selection (GO:0043368)2.86212739
97regulation of T-helper 2 cell differentiation (GO:0045628)2.86192333
98T cell migration (GO:0072678)2.85849475
99dendritic cell chemotaxis (GO:0002407)2.84754455
100negative regulation of interleukin-6 production (GO:0032715)2.82414996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.80835559
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.60558933
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.31950661
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.80004935
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.51846271
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.49695425
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.43029842
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.40741372
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03766944
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.02414373
11SPI1_23547873_ChIP-Seq_NB4_Human2.95331120
12* VDR_21846776_ChIP-Seq_THP-1_Human2.93315787
13* VDR_24763502_ChIP-Seq_THP-1_Human2.83255702
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.83192090
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63274741
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.62431354
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.60136593
18SPI1_23127762_ChIP-Seq_K562_Human2.55569739
19* RUNX_20019798_ChIP-Seq_JUKART_Human2.48451120
20MAF_26560356_Chip-Seq_TH1_Human2.35234789
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34009373
22MYB_26560356_Chip-Seq_TH2_Human2.32813702
23RUNX1_22412390_ChIP-Seq_EML_Mouse2.30952977
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.30839834
25SCL_19346495_ChIP-Seq_HPC-7_Human2.27735743
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27397800
27MYC_22102868_ChIP-Seq_BL_Human2.24114234
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20126856
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.19339157
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17285985
31STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13410141
32* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12668534
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09920436
34UTX_26944678_Chip-Seq_JUKART_Human2.07662177
35MYB_26560356_Chip-Seq_TH1_Human2.02805811
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.98074533
37TCF7_22412390_ChIP-Seq_EML_Mouse1.89595040
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83187548
39* VDR_24787735_ChIP-Seq_THP-1_Human1.80754500
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77070624
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73754873
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69127075
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65626274
44MAF_26560356_Chip-Seq_TH2_Human1.62472083
45GATA3_27048872_Chip-Seq_THYMUS_Human1.60897914
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58760179
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57174248
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55702191
49* KDM2B_26808549_Chip-Seq_DND41_Human1.53179308
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51978377
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.47160168
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.45987396
53* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44513165
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43982773
55PU_27001747_Chip-Seq_BMDM_Mouse1.43037415
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42719014
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41843672
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41033546
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40514321
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39806831
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37054935
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35691413
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34585482
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34473949
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33295931
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32417499
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31034580
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28416245
69GATA3_26560356_Chip-Seq_TH2_Human1.28404872
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25282732
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20781409
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.20765749
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18720499
74LXR_22292898_ChIP-Seq_THP-1_Human1.11917719
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11832109
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11094605
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09742428
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09390908
79GATA1_19941826_ChIP-Seq_K562_Human1.07828785
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05200287
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.04239337
82* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03935858
83PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98486758
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97192803
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97157234
86BCL6_27268052_Chip-Seq_Bcells_Human0.94706735
87BCOR_27268052_Chip-Seq_Bcells_Human0.93265830
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90861966
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90475557
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89257204
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88236763
92NCOR1_26117541_ChIP-Seq_K562_Human0.87414644
93* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87400168
94GATA2_19941826_ChIP-Seq_K562_Human0.87009791
95RXR_22158963_ChIP-Seq_LIVER_Mouse0.86340512
96GATA1_22025678_ChIP-Seq_K562_Human0.86094916
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.80378305
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79754220
99* SPI1_20517297_ChIP-Seq_HL60_Human0.79518846
100STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78087078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.58886958
2MP0001835_abnormal_antigen_presentation4.15971544
3MP0003436_decreased_susceptibility_to4.14706967
4MP0003303_peritoneal_inflammation3.42158602
5MP0002419_abnormal_innate_immunity3.17714484
6MP0001800_abnormal_humoral_immune2.97612631
7MP0005671_abnormal_response_to2.97254315
8MP0000685_abnormal_immune_system2.93697503
9MP0005025_abnormal_response_to2.88643593
10MP0001790_abnormal_immune_system2.82058254
11MP0005387_immune_system_phenotype2.82058254
12MP0009785_altered_susceptibility_to2.80154332
13MP0005000_abnormal_immune_tolerance2.78963817
14MP0006082_CNS_inflammation2.76437149
15MP0002723_abnormal_immune_serum2.54590695
16MP0002452_abnormal_antigen_presenting2.53459701
17MP0002420_abnormal_adaptive_immunity2.50328170
18MP0001819_abnormal_immune_cell2.47434167
19MP0003300_gastrointestinal_ulcer2.25269592
20MP0008260_abnormal_autophagy2.23887157
21MP0003191_abnormal_cellular_cholesterol2.21184785
22MP0003828_pulmonary_edema2.17678203
23MP0002148_abnormal_hypersensitivity_rea2.16470636
24MP0005464_abnormal_platelet_physiology2.16237850
25MP0001533_abnormal_skeleton_physiology2.07347292
26MP0003763_abnormal_thymus_physiology2.05360307
27MP0003172_abnormal_lysosome_physiology2.01303792
28MP0002132_abnormal_respiratory_system1.92838650
29MP0010155_abnormal_intestine_physiology1.92767608
30MP0002398_abnormal_bone_marrow1.87827882
31MP0000716_abnormal_immune_system1.85722100
32MP0002405_respiratory_system_inflammati1.79671353
33MP0001845_abnormal_inflammatory_respons1.79173396
34MP0003183_abnormal_peptide_metabolism1.69184790
35MP0009278_abnormal_bone_marrow1.69124982
36MP0000689_abnormal_spleen_morphology1.62693861
37MP0000465_gastrointestinal_hemorrhage1.62176412
38MP0004947_skin_inflammation1.59325371
39MP0002722_abnormal_immune_system1.56611774
40MP0002166_altered_tumor_susceptibility1.53628149
41MP0003866_abnormal_defecation1.51958878
42MP0009333_abnormal_splenocyte_physiolog1.50022909
43MP0004883_abnormal_blood_vessel1.48018984
44MP0008469_abnormal_protein_level1.47846487
45MP0002429_abnormal_blood_cell1.46916822
46MP0005058_abnormal_lysosome_morphology1.45983757
47MP0001851_eye_inflammation1.43381373
48MP0000858_altered_metastatic_potential1.39648996
49MP0009764_decreased_sensitivity_to1.39193972
50MP0002396_abnormal_hematopoietic_system1.38776092
51MP0005397_hematopoietic_system_phenotyp1.31225251
52MP0001545_abnormal_hematopoietic_system1.31225251
53MP0002138_abnormal_hepatobiliary_system1.29966519
54MP0000703_abnormal_thymus_morphology1.29519843
55MP0002009_preneoplasia1.27260566
56MP0005451_abnormal_body_composition1.26390277
57MP0002998_abnormal_bone_remodeling1.25410518
58MP0005310_abnormal_salivary_gland1.25071245
59MP0004381_abnormal_hair_follicle1.24692185
60MP0008004_abnormal_stomach_pH1.24478615
61MP0003075_altered_response_to1.22208378
62MP0005166_decreased_susceptibility_to1.18388533
63MP0003690_abnormal_glial_cell1.17869548
64MP0004510_myositis1.16539758
65MP0003806_abnormal_nucleotide_metabolis1.15380322
66MP0001853_heart_inflammation1.11864226
67MP0005164_abnormal_response_to1.02085729
68MP0001986_abnormal_taste_sensitivity0.95402686
69MP0002277_abnormal_respiratory_mucosa0.94859173
70MP0005360_urolithiasis0.94811920
71MP0009763_increased_sensitivity_to0.89417586
72MP0002006_tumorigenesis0.87312720
73MP0005085_abnormal_gallbladder_physiolo0.86499570
74MP0003448_altered_tumor_morphology0.85929763
75MP0000604_amyloidosis0.85662382
76MP0001663_abnormal_digestive_system0.85390335
77MP0005075_abnormal_melanosome_morpholog0.84904085
78MP0001873_stomach_inflammation0.82084324
79MP0005390_skeleton_phenotype0.81933123
80MP0000490_abnormal_crypts_of0.80461002
81MP0000343_altered_response_to0.77739268
82MP0003252_abnormal_bile_duct0.76160147
83MP0005365_abnormal_bile_salt0.72344333
84MP0000249_abnormal_blood_vessel0.71402914
85MP0002933_joint_inflammation0.66532644
86MP0004808_abnormal_hematopoietic_stem0.65040459
87MP0000015_abnormal_ear_pigmentation0.63018349
88MP0003221_abnormal_cardiomyocyte_apopto0.62397588
89MP0003795_abnormal_bone_structure0.62247684
90MP0005388_respiratory_system_phenotype0.60432885
91MP0002133_abnormal_respiratory_system0.60432885
92MP0005076_abnormal_cell_differentiation0.59252143
93MP0005319_abnormal_enzyme/_coenzyme0.58786851
94MP0009765_abnormal_xenobiotic_induced0.57238005
95MP0008874_decreased_physiological_sensi0.56761465
96MP0003656_abnormal_erythrocyte_physiolo0.54588227
97MP0000609_abnormal_liver_physiology0.54297207
98MP0003091_abnormal_cell_migration0.53580323
99MP0004264_abnormal_extraembryonic_tissu0.52781793
100MP0005376_homeostasis/metabolism_phenot0.51202516

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.71304793
2Recurrent abscess formation (HP:0002722)6.33738893
3Recurrent bacterial skin infections (HP:0005406)6.29284931
4Abnormality of macrophages (HP:0004311)5.58663655
5Myositis (HP:0100614)5.50605253
6Recurrent gram-negative bacterial infections (HP:0005420)5.50507697
7Orchitis (HP:0100796)5.09809435
8Retrobulbar optic neuritis (HP:0100654)4.88777485
9Optic neuritis (HP:0100653)4.88777485
10Elevated erythrocyte sedimentation rate (HP:0003565)4.71580588
11Stomatitis (HP:0010280)4.59851869
12Recurrent fungal infections (HP:0002841)4.30909094
13Recurrent skin infections (HP:0001581)4.27092941
14Gastrointestinal infarctions (HP:0005244)4.20646010
15Meningitis (HP:0001287)4.18561918
16Obstructive lung disease (HP:0006536)4.07466308
17Chronic obstructive pulmonary disease (HP:0006510)4.07466308
18Mediastinal lymphadenopathy (HP:0100721)4.06654458
19Recurrent cutaneous fungal infections (HP:0011370)3.90386606
20Chronic mucocutaneous candidiasis (HP:0002728)3.90386606
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.80602161
22Encephalitis (HP:0002383)3.73817191
23Amyloidosis (HP:0011034)3.60457449
24Keratoconjunctivitis sicca (HP:0001097)3.59576511
25Gingivitis (HP:0000230)3.59090945
26Vasculitis (HP:0002633)3.55922386
27Urticaria (HP:0001025)3.50064598
28Spontaneous hematomas (HP:0007420)3.48362561
29Prolonged bleeding time (HP:0003010)3.33831612
30Keratoconjunctivitis (HP:0001096)3.29271674
31Cellulitis (HP:0100658)3.22467494
32Increased IgE level (HP:0003212)3.19277203
33Gingival bleeding (HP:0000225)3.16723723
34Chest pain (HP:0100749)3.16649335
35Hemoptysis (HP:0002105)3.14701108
36Recurrent viral infections (HP:0004429)3.12568791
37Episodic fever (HP:0001954)3.09303435
38Pulmonary infiltrates (HP:0002113)3.01203101
39Inflammation of the large intestine (HP:0002037)2.88629307
40Epistaxis (HP:0000421)2.87283490
41Leukocytosis (HP:0001974)2.86994023
42Arterial thrombosis (HP:0004420)2.86888025
43Panhypogammaglobulinemia (HP:0003139)2.82663974
44Pulmonary embolism (HP:0002204)2.82049233
45Peritonitis (HP:0002586)2.81931532
46Gastrointestinal inflammation (HP:0004386)2.79913069
47T lymphocytopenia (HP:0005403)2.76167914
48Osteomyelitis (HP:0002754)2.74128258
49Anorexia (HP:0002039)2.72455821
50Petechiae (HP:0000967)2.67485774
51Abnormality of T cell number (HP:0011839)2.65138813
52Increased cerebral lipofuscin (HP:0011813)2.58680214
53Colitis (HP:0002583)2.58504819
54Hypochromic anemia (HP:0001931)2.57946847
55Hypochromic microcytic anemia (HP:0004840)2.57834714
56Agammaglobulinemia (HP:0004432)2.55752922
57Pustule (HP:0200039)2.55711575
58Malnutrition (HP:0004395)2.47996478
59Purpura (HP:0000979)2.46170691
60Gangrene (HP:0100758)2.41329357
61Abnormality of T cells (HP:0002843)2.40879903
62Granulocytopenia (HP:0001913)2.35031035
63Lymphopenia (HP:0001888)2.34970465
64Systemic lupus erythematosus (HP:0002725)2.34514078
65Abnormality of the pleura (HP:0002103)2.31684039
66Sepsis (HP:0100806)2.29226307
67Increased IgM level (HP:0003496)2.27672792
68Increased serum ferritin (HP:0003281)2.22058010
69Abnormal platelet volume (HP:0011876)2.19299166
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.17916301
71Abnormality of the peritoneum (HP:0002585)2.15692999
72Skin ulcer (HP:0200042)2.14504026
73Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14255587
74Abnormality of T cell physiology (HP:0011840)2.11216259
75Skin rash (HP:0000988)2.10337781
76Recurrent pneumonia (HP:0006532)2.08531209
77Loss of speech (HP:0002371)2.05746270
78Acute hepatic failure (HP:0006554)2.05234145
79Glomerulopathy (HP:0100820)2.04971391
80Vertigo (HP:0002321)2.03840051
81Abnormality of glycolipid metabolism (HP:0010969)2.03169762
82Abnormality of liposaccharide metabolism (HP:0010968)2.03169762
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.03169762
84Abnormality of iron homeostasis (HP:0011031)2.02431478
85Hepatosplenomegaly (HP:0001433)2.00613917
86Increased neuronal autofluorescent lipopigment (HP:0002074)1.99584323
87Thrombophlebitis (HP:0004418)1.98509224
88Abnormality of the endocardium (HP:0004306)1.97467413
89Amaurosis fugax (HP:0100576)1.95275672
90Hypergammaglobulinemia (HP:0010702)1.94883579
91Eosinophilia (HP:0001880)1.94713203
92Microcytic anemia (HP:0001935)1.94704244
93Polyneuropathy (HP:0001271)1.94436969
94IgM deficiency (HP:0002850)1.91795303
95Viral hepatitis (HP:0006562)1.90134155
96Recurrent lower respiratory tract infections (HP:0002783)1.88647793
97Cheilitis (HP:0100825)1.86315623
98Gastrointestinal stroma tumor (HP:0100723)1.85726003
99Papilloma (HP:0012740)1.83742967
100Verrucae (HP:0200043)1.83742967

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.30733900
2BLK3.75134821
3MAP4K13.37992988
4TYK23.14514833
5MAP2K33.08775837
6PRPF4B2.79553776
7FES2.79486323
8IRAK42.77849571
9CSK2.73411388
10ERN12.63212863
11ZAP702.19215824
12GRK62.16027026
13TNK22.10712282
14FGR1.99011204
15BTK1.98022923
16MAP3K31.91515192
17SYK1.91038751
18MAP3K141.80974117
19JAK31.80762222
20MAP3K131.74897771
21HCK1.71456780
22TXK1.52784720
23TAOK11.50727602
24CSF1R1.49462872
25LYN1.44439427
26IKBKE1.43803090
27JAK11.40213607
28EPHB11.37861508
29JAK21.37057263
30SIK31.34648242
31TBK11.33216868
32KIT1.32147961
33MAP3K111.31102341
34TEC1.30551286
35MAP3K11.29440842
36YES11.28879656
37BMPR21.26936695
38CDK191.26233417
39LCK1.15628355
40ITK1.15040725
41KSR21.14717678
42STK101.09894650
43IRAK21.05219227
44PIK3CG0.96642304
45TGFBR20.96600628
46PDK10.95337097
47MARK30.95147534
48TAOK30.93780821
49MARK20.90457055
50MATK0.90264629
51IRAK10.88872937
52PDPK10.86423614
53LRRK20.82704350
54MAP3K60.82333139
55MAPK120.81886170
56MAPK70.80449950
57IKBKB0.79400947
58PTK60.77398310
59FYN0.68009805
60TRIB30.67690796
61PRKD20.67222334
62TAOK20.65695822
63MAP3K70.64986779
64MAP3K20.61905242
65SIK20.60332534
66DYRK1B0.58808611
67TESK20.56388255
68PRKCQ0.56351796
69CDK60.54308317
70CDC42BPA0.54092732
71MAP3K50.52081335
72MAP2K40.51856616
73SGK30.49238689
74FGFR30.47059180
75MOS0.46752819
76NLK0.45468071
77STK110.44964595
78MAP3K100.43606154
79SMG10.42683059
80RPS6KC10.41472231
81RPS6KL10.41472231
82PTK2B0.40986685
83PIM10.39526221
84MAP3K80.36774113
85MAPKAPK20.36058071
86CDK40.33900533
87RAF10.33505387
88RET0.33415438
89RPS6KA60.32163431
90FGFR40.32055200
91MAP2K20.31177706
92HIPK20.31111340
93PRKG20.30957102
94SGK20.30760497
95SIK10.30054303
96KSR10.29921770
97ACVR1B0.29463364
98GRK70.28272302
99ABL10.28029137
100PRKD10.27989426

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.37664145
2Leishmaniasis_Homo sapiens_hsa051403.36831926
3Osteoclast differentiation_Homo sapiens_hsa043803.05998735
4Allograft rejection_Homo sapiens_hsa053302.73115054
5Graft-versus-host disease_Homo sapiens_hsa053322.70128448
6Autoimmune thyroid disease_Homo sapiens_hsa053202.57008564
7B cell receptor signaling pathway_Homo sapiens_hsa046622.41106538
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.35549558
9Tuberculosis_Homo sapiens_hsa051522.29253003
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.13683781
11Primary immunodeficiency_Homo sapiens_hsa053402.12392487
12Asthma_Homo sapiens_hsa053102.11273812
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04243410
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.01031390
15Type I diabetes mellitus_Homo sapiens_hsa049401.98053570
16Antigen processing and presentation_Homo sapiens_hsa046121.94938115
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.94318095
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89423209
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.88766603
20Viral myocarditis_Homo sapiens_hsa054161.79163098
21* Hematopoietic cell lineage_Homo sapiens_hsa046401.68851899
22Malaria_Homo sapiens_hsa051441.66093850
23Other glycan degradation_Homo sapiens_hsa005111.65930189
24Toxoplasmosis_Homo sapiens_hsa051451.63119926
25Chemokine signaling pathway_Homo sapiens_hsa040621.60317745
26Legionellosis_Homo sapiens_hsa051341.58955682
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56673624
28T cell receptor signaling pathway_Homo sapiens_hsa046601.52037064
29Acute myeloid leukemia_Homo sapiens_hsa052211.51996107
30Influenza A_Homo sapiens_hsa051641.51479827
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.50928658
32Measles_Homo sapiens_hsa051621.50719346
33Phagosome_Homo sapiens_hsa041451.47673916
34Herpes simplex infection_Homo sapiens_hsa051681.38302013
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.25084478
36Pertussis_Homo sapiens_hsa051331.22697091
37Platelet activation_Homo sapiens_hsa046111.17896147
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15289050
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.14476629
40Rheumatoid arthritis_Homo sapiens_hsa053231.10367673
41Non-small cell lung cancer_Homo sapiens_hsa052231.08489487
42Hepatitis B_Homo sapiens_hsa051611.05417515
43TNF signaling pathway_Homo sapiens_hsa046681.04578804
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03941447
45African trypanosomiasis_Homo sapiens_hsa051430.96817362
46Shigellosis_Homo sapiens_hsa051310.91765204
47Salmonella infection_Homo sapiens_hsa051320.91291066
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87216683
49Hepatitis C_Homo sapiens_hsa051600.82780195
50Pancreatic cancer_Homo sapiens_hsa052120.80751705
51Lysosome_Homo sapiens_hsa041420.78065494
52Chronic myeloid leukemia_Homo sapiens_hsa052200.76238636
53Apoptosis_Homo sapiens_hsa042100.74187468
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73544511
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71849317
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71580522
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.69900542
58Renal cell carcinoma_Homo sapiens_hsa052110.69514520
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66943675
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.65287600
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65079736
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64128841
63VEGF signaling pathway_Homo sapiens_hsa043700.63035072
64Epstein-Barr virus infection_Homo sapiens_hsa051690.62504855
65Complement and coagulation cascades_Homo sapiens_hsa046100.62082959
66GnRH signaling pathway_Homo sapiens_hsa049120.60835558
67Endocytosis_Homo sapiens_hsa041440.60485689
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.59887269
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58720127
70Prolactin signaling pathway_Homo sapiens_hsa049170.56635392
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.55980812
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.55949950
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55907692
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55280041
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54522687
76FoxO signaling pathway_Homo sapiens_hsa040680.53377165
77* Amoebiasis_Homo sapiens_hsa051460.53128872
78Choline metabolism in cancer_Homo sapiens_hsa052310.52857077
79HTLV-I infection_Homo sapiens_hsa051660.51946838
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51519995
81HIF-1 signaling pathway_Homo sapiens_hsa040660.49523359
82Notch signaling pathway_Homo sapiens_hsa043300.47947030
83Insulin resistance_Homo sapiens_hsa049310.47113060
84Viral carcinogenesis_Homo sapiens_hsa052030.46637378
85Dorso-ventral axis formation_Homo sapiens_hsa043200.44358818
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.43454359
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.43279978
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42651298
89Endometrial cancer_Homo sapiens_hsa052130.42205802
90Inositol phosphate metabolism_Homo sapiens_hsa005620.40376914
91Colorectal cancer_Homo sapiens_hsa052100.39789474
92Type II diabetes mellitus_Homo sapiens_hsa049300.34283420
93Arachidonic acid metabolism_Homo sapiens_hsa005900.34249326
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34163608
95Regulation of autophagy_Homo sapiens_hsa041400.33331503
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28485091
97MAPK signaling pathway_Homo sapiens_hsa040100.27905120
98Galactose metabolism_Homo sapiens_hsa000520.27744441
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27701945
100mTOR signaling pathway_Homo sapiens_hsa041500.27077387

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