CD1E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.41751111
2negative thymic T cell selection (GO:0045060)8.09253716
3positive T cell selection (GO:0043368)7.08559127
4V(D)J recombination (GO:0033151)6.90824931
5positive thymic T cell selection (GO:0045059)6.89869409
6positive regulation of granulocyte differentiation (GO:0030854)6.24792719
7T cell selection (GO:0045058)6.16701048
8immunoglobulin mediated immune response (GO:0016064)6.14998740
9thymic T cell selection (GO:0045061)5.94093195
10negative regulation of thymocyte apoptotic process (GO:0070244)5.44061451
11positive regulation of gamma-delta T cell activation (GO:0046645)5.29482041
12regulation of hypersensitivity (GO:0002883)5.21006054
13regulation of interleukin-4 production (GO:0032673)5.07030243
14Peyers patch development (GO:0048541)5.03351127
15mucosal-associated lymphoid tissue development (GO:0048537)5.03351127
16T cell costimulation (GO:0031295)4.78959767
17lymphocyte costimulation (GO:0031294)4.73752963
18B cell mediated immunity (GO:0019724)4.73454310
19cellular extravasation (GO:0045123)4.72027337
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.60822613
21positive regulation of mast cell activation (GO:0033005)4.44133959
22regulation of granulocyte differentiation (GO:0030852)4.41813205
23positive regulation of antigen processing and presentation (GO:0002579)4.36891644
24negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.20942833
25regulation of interleukin-2 biosynthetic process (GO:0045076)4.05128631
26negative regulation of myotube differentiation (GO:0010832)3.96758475
27response to muramyl dipeptide (GO:0032495)3.92892131
28positive regulation of mast cell degranulation (GO:0043306)3.92819566
29positive regulation of mast cell activation involved in immune response (GO:0033008)3.92819566
30chaperone mediated protein folding requiring cofactor (GO:0051085)3.91049751
31regulation of gamma-delta T cell differentiation (GO:0045586)3.90307306
32regulation of gamma-delta T cell activation (GO:0046643)3.89466364
33negative regulation of B cell apoptotic process (GO:0002903)3.82734167
34regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.78203057
35adhesion of symbiont to host cell (GO:0044650)3.69464303
36virion attachment to host cell (GO:0019062)3.69464303
37positive regulation of B cell differentiation (GO:0045579)3.67300842
38positive regulation of type 2 immune response (GO:0002830)3.57903233
39regulation of mast cell activation (GO:0033003)3.56270399
40T cell activation involved in immune response (GO:0002286)3.51828098
41positive regulation by host of viral transcription (GO:0043923)3.50143520
42regulation of antigen processing and presentation (GO:0002577)3.48961922
43antigen processing and presentation of endogenous antigen (GO:0019883)3.48813212
44regulation of dendritic cell antigen processing and presentation (GO:0002604)3.47778375
45granulocyte differentiation (GO:0030851)3.47330149
46radial glial cell differentiation (GO:0060019)3.42161851
47interferon-gamma-mediated signaling pathway (GO:0060333)3.41873961
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.38388471
49T cell receptor signaling pathway (GO:0050852)3.37987546
50pinocytosis (GO:0006907)3.30101681
51regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.29234922
52detection of bacterium (GO:0016045)3.28667440
53mature B cell differentiation involved in immune response (GO:0002313)3.25830338
54regulation of inflammatory response to antigenic stimulus (GO:0002861)3.25786293
55wound healing, spreading of epidermal cells (GO:0035313)3.25388378
56positive regulation of alpha-beta T cell differentiation (GO:0046638)3.21595134
57purine deoxyribonucleotide catabolic process (GO:0009155)3.20964804
58histamine secretion (GO:0001821)3.19996569
59regulation of mast cell degranulation (GO:0043304)3.19637553
60negative regulation of T cell apoptotic process (GO:0070233)3.19064312
61regulation of thymocyte apoptotic process (GO:0070243)3.16443363
62positive regulation of calcium-mediated signaling (GO:0050850)3.15409304
63apoptotic process involved in morphogenesis (GO:0060561)3.13896810
64neutrophil activation involved in immune response (GO:0002283)3.13312056
65regulation of interleukin-13 production (GO:0032656)3.13216935
66positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.13094177
67developmental pigmentation (GO:0048066)3.12054943
68antigen receptor-mediated signaling pathway (GO:0050851)3.11561846
69adhesion of symbiont to host (GO:0044406)3.10798800
70positive regulation of macrophage cytokine production (GO:0060907)3.10114055
71myeloid dendritic cell activation (GO:0001773)3.09492105
72negative regulation of T cell mediated immunity (GO:0002710)3.08894103
73detection of other organism (GO:0098543)3.08062704
74positive regulation of alpha-beta T cell activation (GO:0046635)3.05709724
75activated T cell proliferation (GO:0050798)3.04513481
76cellular response to interleukin-4 (GO:0071353)3.03831919
77regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.01657568
78positive regulation of interleukin-2 production (GO:0032743)3.01310496
79histone H3-K36 demethylation (GO:0070544)3.01220124
80regulation of T cell tolerance induction (GO:0002664)3.00822206
81positive regulation of B cell proliferation (GO:0030890)2.98912332
82regulation of mast cell activation involved in immune response (GO:0033006)2.98436413
83generation of neurons (GO:0048699)2.98418901
84regulation of B cell receptor signaling pathway (GO:0050855)2.98357051
85negative regulation of lymphocyte apoptotic process (GO:0070229)2.96620160
86CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.93023207
87T-helper cell differentiation (GO:0042093)2.93023207
88regulation of alpha-beta T cell differentiation (GO:0046637)2.92074184
89T-helper 1 type immune response (GO:0042088)2.89997275
90negative regulation of adaptive immune response (GO:0002820)2.89277470
91regulation of T-helper 2 cell differentiation (GO:0045628)2.89205830
92positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87396490
93regulation of receptor binding (GO:1900120)2.86295602
94B cell proliferation (GO:0042100)2.84058475
95response to peptidoglycan (GO:0032494)2.81782923
96regulation of germinal center formation (GO:0002634)2.81126069
97hepatocyte apoptotic process (GO:0097284)2.79430832
98positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.79372598
99positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.79288332
100regulation of type 2 immune response (GO:0002828)2.78960270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.72031382
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.92271237
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.51197399
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.37473292
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.99545026
6RUNX_20019798_ChIP-Seq_JUKART_Human3.93256530
7SCL_19346495_ChIP-Seq_HPC-7_Human3.63296840
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.55352238
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.09260038
10MYC_22102868_ChIP-Seq_BL_Human2.95176574
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91316607
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91302082
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89186328
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.87643550
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.80995874
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.73872027
17CIITA_25753668_ChIP-Seq_RAJI_Human2.69331682
18* GATA3_27048872_Chip-Seq_THYMUS_Human2.67955810
19VDR_21846776_ChIP-Seq_THP-1_Human2.63520191
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.61933545
21MYB_26560356_Chip-Seq_TH2_Human2.57306256
22UTX_26944678_Chip-Seq_JUKART_Human2.54833394
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47816715
24VDR_24763502_ChIP-Seq_THP-1_Human2.38707072
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37691799
26SPI1_23547873_ChIP-Seq_NB4_Human2.36203771
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32100937
28SPI1_23127762_ChIP-Seq_K562_Human2.16899159
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12215816
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.09803727
31RUNX1_17652178_ChIP-ChIP_JURKAT_Human2.00172750
32MAF_26560356_Chip-Seq_TH1_Human1.94456474
33MYB_26560356_Chip-Seq_TH1_Human1.91836313
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91094600
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.89952758
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87636370
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86016431
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79074153
39TCF7_22412390_ChIP-Seq_EML_Mouse1.77682515
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76078884
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74600883
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72195448
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72133177
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62045660
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61001758
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.60139020
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58299070
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.57804715
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49428290
50MAF_26560356_Chip-Seq_TH2_Human1.46499754
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45117122
52KDM2B_26808549_Chip-Seq_DND41_Human1.44029009
53VDR_24787735_ChIP-Seq_THP-1_Human1.42090820
54TP63_17297297_ChIP-ChIP_HaCaT_Human1.40414666
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36233130
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36103904
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34574946
58PU_27001747_Chip-Seq_BMDM_Mouse1.34558367
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32632208
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23174334
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21769659
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21457175
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18795322
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18608032
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16281340
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15425763
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14333792
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13741860
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10539889
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09501732
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08866635
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.07819677
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04941149
74GATA3_26560356_Chip-Seq_TH2_Human1.04795948
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.01948164
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00188554
77ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99522720
78IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98541793
79GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98218968
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97816641
81E2F1_21310950_ChIP-Seq_MCF-7_Human0.97181582
82HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95500316
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94275340
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94176377
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94087869
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93738306
87GATA1_19941826_ChIP-Seq_K562_Human0.93272340
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88900458
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84763918
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.84706644
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84510732
92SPI1_20517297_ChIP-Seq_HL60_Human0.83604229
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82938574
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82490964
95FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.82177299
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82057796
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82028794
98LXR_22292898_ChIP-Seq_THP-1_Human0.77979812
99NCOR1_26117541_ChIP-Seq_K562_Human0.77570882
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76124669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.61816026
2MP0002396_abnormal_hematopoietic_system4.26916123
3MP0004381_abnormal_hair_follicle4.13108068
4MP0001835_abnormal_antigen_presentation3.76240395
5MP0003763_abnormal_thymus_physiology3.33685441
6MP0002148_abnormal_hypersensitivity_rea2.85140119
7MP0000685_abnormal_immune_system2.68024548
8MP0005075_abnormal_melanosome_morpholog2.57443108
9MP0003172_abnormal_lysosome_physiology2.56512977
10MP0000569_abnormal_digit_pigmentation2.56129549
11MP0003300_gastrointestinal_ulcer2.39720816
12MP0002405_respiratory_system_inflammati2.35439471
13MP0001800_abnormal_humoral_immune2.32267732
14MP0003279_aneurysm2.26949692
15MP0001790_abnormal_immune_system2.21670658
16MP0005387_immune_system_phenotype2.21670658
17MP0005025_abnormal_response_to2.15668808
18MP0002009_preneoplasia2.15263442
19MP0005000_abnormal_immune_tolerance2.14737974
20MP0004947_skin_inflammation2.14197671
21MP0000703_abnormal_thymus_morphology2.12465652
22MP0002452_abnormal_antigen_presenting2.10402080
23MP0002398_abnormal_bone_marrow2.07339159
24MP0002419_abnormal_innate_immunity2.06543844
25MP0002420_abnormal_adaptive_immunity2.05424824
26MP0005451_abnormal_body_composition2.04472712
27MP0001819_abnormal_immune_cell2.03723010
28MP0005464_abnormal_platelet_physiology1.98294300
29MP0002166_altered_tumor_susceptibility1.93472545
30MP0000015_abnormal_ear_pigmentation1.93431632
31MP0005058_abnormal_lysosome_morphology1.92259346
32MP0002723_abnormal_immune_serum1.88103639
33MP0003436_decreased_susceptibility_to1.82250147
34MP0000716_abnormal_immune_system1.79940097
35MP0002722_abnormal_immune_system1.77907094
36MP0008057_abnormal_DNA_replication1.71657246
37MP0000689_abnormal_spleen_morphology1.62454464
38MP0001958_emphysema1.59781862
39MP0005647_abnormal_sex_gland1.56778643
40MP0002877_abnormal_melanocyte_morpholog1.55693700
41MP0001853_heart_inflammation1.55645903
42MP0002429_abnormal_blood_cell1.49570348
43MP0005166_decreased_susceptibility_to1.48019547
44MP0005397_hematopoietic_system_phenotyp1.41084876
45MP0001545_abnormal_hematopoietic_system1.41084876
46MP0004185_abnormal_adipocyte_glucose1.39308700
47MP0005174_abnormal_tail_pigmentation1.39020106
48MP0010094_abnormal_chromosome_stability1.31411957
49MP0009278_abnormal_bone_marrow1.29007928
50MP0008004_abnormal_stomach_pH1.26831949
51MP0004808_abnormal_hematopoietic_stem1.26407107
52MP0003724_increased_susceptibility_to1.24190544
53MP0009785_altered_susceptibility_to1.21931823
54MP0003075_altered_response_to1.21408502
55MP0006082_CNS_inflammation1.19175487
56MP0003183_abnormal_peptide_metabolism1.17525406
57MP0010307_abnormal_tumor_latency1.16117052
58MP0001845_abnormal_inflammatory_respons1.14046650
59MP0010155_abnormal_intestine_physiology1.13943354
60MP0000858_altered_metastatic_potential1.13564493
61MP0009333_abnormal_splenocyte_physiolog1.13013171
62MP0009115_abnormal_fat_cell1.11296959
63MP0002006_tumorigenesis1.11231789
64MP0003705_abnormal_hypodermis_morpholog1.06451297
65MP0003303_peritoneal_inflammation1.05104242
66MP0002998_abnormal_bone_remodeling1.04850592
67MP0008877_abnormal_DNA_methylation1.01481929
68MP0001986_abnormal_taste_sensitivity0.99226225
69MP0009697_abnormal_copulation0.98503824
70MP0005670_abnormal_white_adipose0.98385419
71MP0004084_abnormal_cardiac_muscle0.97559218
72MP0004036_abnormal_muscle_relaxation0.96884964
73MP0001533_abnormal_skeleton_physiology0.94674315
74MP0005409_darkened_coat_color0.94135343
75MP0002796_impaired_skin_barrier0.93416751
76MP0002970_abnormal_white_adipose0.89699457
77MP0000343_altered_response_to0.87649459
78MP0001849_ear_inflammation0.86208351
79MP0004264_abnormal_extraembryonic_tissu0.85853638
80MP0005666_abnormal_adipose_tissue0.84226495
81MP0008469_abnormal_protein_level0.82930019
82MP0002019_abnormal_tumor_incidence0.82571320
83MP0003828_pulmonary_edema0.79640545
84MP0000920_abnormal_myelination0.78752370
85MP0008007_abnormal_cellular_replicative0.75501850
86MP0005310_abnormal_salivary_gland0.74409829
87MP0000371_diluted_coat_color0.74098178
88MP0000490_abnormal_crypts_of0.73085071
89MP0001851_eye_inflammation0.72883402
90MP0002971_abnormal_brown_adipose0.71053660
91MP0001727_abnormal_embryo_implantation0.68383563
92MP0003111_abnormal_nucleus_morphology0.68007245
93MP0003866_abnormal_defecation0.66374822
94MP0000627_abnormal_mammary_gland0.64510697
95MP0003252_abnormal_bile_duct0.63403108
96MP0009763_increased_sensitivity_to0.62207054
97MP0003448_altered_tumor_morphology0.60699103
98MP0009764_decreased_sensitivity_to0.59252211
99MP0000465_gastrointestinal_hemorrhage0.57929215
100MP0009931_abnormal_skin_appearance0.57180863

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)6.76769033
2Panhypogammaglobulinemia (HP:0003139)5.51491702
3B lymphocytopenia (HP:0010976)5.48186840
4Severe combined immunodeficiency (HP:0004430)5.21635890
5Abnormality of B cell number (HP:0010975)4.93034262
6Combined immunodeficiency (HP:0005387)4.86437788
7Recurrent cutaneous fungal infections (HP:0011370)4.82331514
8Chronic mucocutaneous candidiasis (HP:0002728)4.82331514
9Recurrent fungal infections (HP:0002841)4.61461711
10Hypoplasia of the thymus (HP:0000778)3.99406373
11Abnormality of macrophages (HP:0004311)3.88738541
12Recurrent abscess formation (HP:0002722)3.81919584
13Esophageal varix (HP:0002040)3.79487780
14Thyroiditis (HP:0100646)3.78784167
15Meningitis (HP:0001287)3.71081350
16Recurrent viral infections (HP:0004429)3.68291148
17Increased IgE level (HP:0003212)3.68220682
18Abnormality of the prostate (HP:0008775)3.44906898
19Systemic lupus erythematosus (HP:0002725)3.37130841
20Colitis (HP:0002583)3.35410927
21Recurrent skin infections (HP:0001581)3.30807649
22T lymphocytopenia (HP:0005403)3.30106726
23Eczematoid dermatitis (HP:0000976)3.29440190
24Recurrent bacterial skin infections (HP:0005406)3.27823648
25Increased cerebral lipofuscin (HP:0011813)3.26485235
26Autoimmune thrombocytopenia (HP:0001973)3.22308546
27Abnormality of glycolipid metabolism (HP:0010969)3.09287961
28Abnormality of liposaccharide metabolism (HP:0010968)3.09287961
29Abnormality of glycosphingolipid metabolism (HP:0004343)3.09287961
30Broad face (HP:0000283)3.06591166
31Subaortic stenosis (HP:0001682)3.05210589
32Abnormality of the left ventricular outflow tract (HP:0011103)3.05210589
33Granulocytopenia (HP:0001913)2.93701332
34Spontaneous hematomas (HP:0007420)2.93139053
35Obstructive lung disease (HP:0006536)2.88167034
36Chronic obstructive pulmonary disease (HP:0006510)2.88167034
37Eosinophilia (HP:0001880)2.86930985
38Acute lymphatic leukemia (HP:0006721)2.86200492
39Increased neuronal autofluorescent lipopigment (HP:0002074)2.81455830
40Autoimmune hemolytic anemia (HP:0001890)2.73550363
41Abnormality of T cell number (HP:0011839)2.72301942
42Polygenic inheritance (HP:0010982)2.64597134
43Inflammation of the large intestine (HP:0002037)2.64313713
44Mediastinal lymphadenopathy (HP:0100721)2.63799996
45Gastrointestinal inflammation (HP:0004386)2.61855068
46Amaurosis fugax (HP:0100576)2.60832290
47Abnormality of the columella (HP:0009929)2.55111632
48Protuberant abdomen (HP:0001538)2.55071480
49Aplasia/Hypoplasia of the thymus (HP:0010515)2.54706695
50Thoracic kyphosis (HP:0002942)2.49554462
51Hemoptysis (HP:0002105)2.49117632
52Spondylolisthesis (HP:0003302)2.48405653
53Loss of speech (HP:0002371)2.47850137
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.40955919
55Prostate neoplasm (HP:0100787)2.36505202
56Hepatosplenomegaly (HP:0001433)2.33815212
57Dysostosis multiplex (HP:0000943)2.33151332
58Chest pain (HP:0100749)2.30848998
59Upper motor neuron abnormality (HP:0002127)2.29939660
60Adactyly (HP:0009776)2.28265086
61Basal ganglia calcification (HP:0002135)2.27971605
62Viral hepatitis (HP:0006562)2.26220564
63Aplasia cutis congenita (HP:0001057)2.24993565
64Multiple lipomas (HP:0001012)2.23587374
65Leukocytosis (HP:0001974)2.18815285
66Acute myeloid leukemia (HP:0004808)2.16951580
67Pulmonary infiltrates (HP:0002113)2.14776624
68Xerostomia (HP:0000217)2.13028178
69Cutis marmorata (HP:0000965)2.11705285
70Mucosal telangiectasiae (HP:0100579)2.10807133
71Epistaxis (HP:0000421)2.08647868
72Agammaglobulinemia (HP:0004432)2.08153525
73Porencephaly (HP:0002132)2.07983535
74Urticaria (HP:0001025)2.07512350
75Abnormality of eosinophils (HP:0001879)2.06682656
76Axonal loss (HP:0003447)2.04900214
77Abnormality of male internal genitalia (HP:0000022)2.03484997
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.01809833
79Ureteral stenosis (HP:0000071)2.01539031
80Abnormality of the thymus (HP:0000777)2.01520960
81Mutism (HP:0002300)2.00260753
82Abnormality of T cells (HP:0002843)1.99658298
83Vasculitis (HP:0002633)1.98365831
84Cheilitis (HP:0100825)1.95327072
85Absent hand (HP:0004050)1.93961865
86Ureteral obstruction (HP:0006000)1.91896978
87Hypertensive crisis (HP:0100735)1.91515563
88Disinhibition (HP:0000734)1.90913634
89Supernumerary nipples (HP:0002558)1.90718642
90Encephalitis (HP:0002383)1.89975384
91Increased IgM level (HP:0003496)1.89577266
92Pulmonary fibrosis (HP:0002206)1.89542576
93Lymphoma (HP:0002665)1.88516914
94Lymphopenia (HP:0001888)1.85995519
95Acrocyanosis (HP:0001063)1.84849411
96Abnormality of the pleura (HP:0002103)1.82421745
97Deformed sella turcica (HP:0002681)1.82361642
98Cupped ribs (HP:0000887)1.82316826
99Nephroblastoma (Wilms tumor) (HP:0002667)1.82225309
100Abnormality of the thoracic spine (HP:0100711)1.81963940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NLK4.09283354
2CDK123.25544492
3BLK3.14636413
4PRPF4B2.83867525
5SMG12.77370695
6TYK22.66988162
7CSF1R2.46659499
8MAP3K102.38017381
9CAMKK22.22008742
10TAF12.17856497
11PIK3CG2.15912452
12TLK12.06867547
13CDK62.03866903
14ZAP701.97308902
15MAP4K11.94261578
16RIPK41.93969472
17BRD41.81281360
18FES1.79786155
19SYK1.78483560
20BTK1.77899118
21MAP3K131.75543728
22VRK11.65417467
23ITK1.60735453
24MAP3K141.60253495
25CAMKK11.55269014
26JAK31.49589320
27ZAK1.47313416
28EEF2K1.43037824
29MARK21.39644565
30BMPR21.35742864
31ICK1.35636142
32CDK41.33196498
33NEK91.32272274
34CSK1.30629292
35CDC42BPA1.27981384
36MAP3K71.25911377
37PRKCQ1.21891899
38MAPK111.21509533
39TRIB31.21387794
40CDK71.18378974
41KIT1.17052731
42DAPK31.16964022
43HCK1.14830371
44SCYL21.13339588
45MAPK121.11714406
46CAMK41.05009282
47LCK0.99213416
48LYN0.93552017
49CDK90.92237823
50MAP3K20.92147061
51TRPM70.82324262
52TEC0.78907157
53STK240.77980942
54CAMK1D0.76096776
55TTN0.73346636
56MAPK70.70513585
57RPS6KA50.69164587
58MAPKAPK50.65863602
59VRK20.64780823
60JAK20.61854093
61MAP3K80.60560607
62JAK10.56959540
63HIPK20.56608077
64CHEK20.55359195
65CAMK1G0.54875898
66TXK0.52268143
67RPS6KA20.51751810
68CAMK10.51546293
69GRK60.51287305
70RPS6KA40.50923953
71RPS6KC10.50188183
72RPS6KL10.50188183
73PDK10.50012534
74CDK80.50009554
75CDC70.49800564
76YES10.49170524
77CSNK1A1L0.48430644
78WNK10.48383490
79STK40.46029475
80FLT30.45307755
81MELK0.45129965
82CSNK1G30.44910323
83KSR20.44240263
84KDR0.44135712
85GRK70.43775249
86DAPK10.41964364
87TESK20.41501963
88ATR0.39533054
89SGK30.38325477
90RPS6KB20.38159657
91FGR0.36238183
92MAPKAPK20.35851722
93IRAK40.35630256
94RPS6KA60.35531041
95MAP3K10.34183991
96IKBKB0.34105390
97BRAF0.34092910
98PIM20.32204633
99MAPK40.31388003
100MAPK30.30957700

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.94560193
2Allograft rejection_Homo sapiens_hsa053304.19080640
3Autoimmune thyroid disease_Homo sapiens_hsa053204.05595775
4* Hematopoietic cell lineage_Homo sapiens_hsa046403.87622090
5Graft-versus-host disease_Homo sapiens_hsa053323.82335035
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.68637038
7Staphylococcus aureus infection_Homo sapiens_hsa051503.26531785
8Type I diabetes mellitus_Homo sapiens_hsa049403.26371873
9Systemic lupus erythematosus_Homo sapiens_hsa053223.18409064
10Leishmaniasis_Homo sapiens_hsa051402.73150315
11Viral myocarditis_Homo sapiens_hsa054162.69655469
12Primary immunodeficiency_Homo sapiens_hsa053402.39431797
13Antigen processing and presentation_Homo sapiens_hsa046122.30752115
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22340861
15Tuberculosis_Homo sapiens_hsa051521.91266377
16Rheumatoid arthritis_Homo sapiens_hsa053231.78863983
17Thyroid cancer_Homo sapiens_hsa052161.68146348
18Acute myeloid leukemia_Homo sapiens_hsa052211.58667355
19Alcoholism_Homo sapiens_hsa050341.48098585
20Toxoplasmosis_Homo sapiens_hsa051451.46481291
21T cell receptor signaling pathway_Homo sapiens_hsa046601.35025376
22Non-small cell lung cancer_Homo sapiens_hsa052231.29217105
23Phagosome_Homo sapiens_hsa041451.28350901
24B cell receptor signaling pathway_Homo sapiens_hsa046621.27761402
25Influenza A_Homo sapiens_hsa051641.26767085
26Herpes simplex infection_Homo sapiens_hsa051681.20003107
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09532728
28Viral carcinogenesis_Homo sapiens_hsa052031.08200936
29Measles_Homo sapiens_hsa051621.07960971
30Endometrial cancer_Homo sapiens_hsa052131.03060131
31Lysosome_Homo sapiens_hsa041421.02905651
32Osteoclast differentiation_Homo sapiens_hsa043801.01632202
33Chronic myeloid leukemia_Homo sapiens_hsa052201.00077535
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97999283
35Pancreatic cancer_Homo sapiens_hsa052120.93099858
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88723988
37Epstein-Barr virus infection_Homo sapiens_hsa051690.87132477
38HTLV-I infection_Homo sapiens_hsa051660.84412146
39Glioma_Homo sapiens_hsa052140.83772103
40Notch signaling pathway_Homo sapiens_hsa043300.82339671
41Colorectal cancer_Homo sapiens_hsa052100.78950556
42DNA replication_Homo sapiens_hsa030300.77028769
43Other glycan degradation_Homo sapiens_hsa005110.76564314
44Prostate cancer_Homo sapiens_hsa052150.76340763
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73189891
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70784184
47Chemokine signaling pathway_Homo sapiens_hsa040620.70653302
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68632256
49Cell cycle_Homo sapiens_hsa041100.68383635
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.67927987
51Steroid biosynthesis_Homo sapiens_hsa001000.61000050
52Platelet activation_Homo sapiens_hsa046110.58234337
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.56803790
54Hepatitis B_Homo sapiens_hsa051610.56455738
55Dorso-ventral axis formation_Homo sapiens_hsa043200.55831742
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.52975632
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48393436
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43409448
59Pertussis_Homo sapiens_hsa051330.41146768
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39818960
61Pentose phosphate pathway_Homo sapiens_hsa000300.38976937
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37437046
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.37137341
64Bladder cancer_Homo sapiens_hsa052190.34219604
65MicroRNAs in cancer_Homo sapiens_hsa052060.34112437
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33979334
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32710334
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.31353315
69Melanoma_Homo sapiens_hsa052180.28181603
70Renal cell carcinoma_Homo sapiens_hsa052110.27993205
71Legionellosis_Homo sapiens_hsa051340.27819952
72Apoptosis_Homo sapiens_hsa042100.24601833
73Adherens junction_Homo sapiens_hsa045200.22696967
74Base excision repair_Homo sapiens_hsa034100.20829828
75Inositol phosphate metabolism_Homo sapiens_hsa005620.20351386
76mTOR signaling pathway_Homo sapiens_hsa041500.20214102
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19951469
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19726732
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.19439110
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19098971
81Non-homologous end-joining_Homo sapiens_hsa034500.19091847
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.16794183
83Shigellosis_Homo sapiens_hsa051310.16537273
84Prolactin signaling pathway_Homo sapiens_hsa049170.16145748
85Hepatitis C_Homo sapiens_hsa051600.16140730
86Homologous recombination_Homo sapiens_hsa034400.14458234
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12999588
88Mismatch repair_Homo sapiens_hsa034300.12900812
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.11890746
90Salmonella infection_Homo sapiens_hsa051320.11717097
91Linoleic acid metabolism_Homo sapiens_hsa005910.11222942
92VEGF signaling pathway_Homo sapiens_hsa043700.10444984
93Small cell lung cancer_Homo sapiens_hsa052220.10378826
94Renin secretion_Homo sapiens_hsa049240.09898563
95Oxytocin signaling pathway_Homo sapiens_hsa049210.09660711
96ErbB signaling pathway_Homo sapiens_hsa040120.09583977
97Choline metabolism in cancer_Homo sapiens_hsa052310.08964031
98Basal cell carcinoma_Homo sapiens_hsa052170.08452498
99p53 signaling pathway_Homo sapiens_hsa041150.07925252
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.07552412

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