CD200

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.68226878
2vocalization behavior (GO:0071625)5.47770319
3synaptic vesicle exocytosis (GO:0016079)4.86044646
4postsynaptic membrane organization (GO:0001941)4.66466973
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.62924297
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.62329044
7presynaptic membrane assembly (GO:0097105)4.54205039
8regulation of synaptic vesicle exocytosis (GO:2000300)4.49032758
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.48649038
10glutamate secretion (GO:0014047)4.33350023
11regulation of glutamate receptor signaling pathway (GO:1900449)4.23223971
12synaptic vesicle maturation (GO:0016188)4.16938700
13protein localization to synapse (GO:0035418)4.13957479
14presynaptic membrane organization (GO:0097090)4.02952005
15neurotransmitter-gated ion channel clustering (GO:0072578)3.99506869
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.99136929
17behavioral response to nicotine (GO:0035095)3.96774503
18synaptic vesicle docking involved in exocytosis (GO:0016081)3.94900499
19establishment of mitochondrion localization (GO:0051654)3.90321412
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.89255915
21regulation of synaptic vesicle transport (GO:1902803)3.86970657
22locomotory exploration behavior (GO:0035641)3.84894962
23neurotransmitter secretion (GO:0007269)3.82646039
24neuron recognition (GO:0008038)3.72726488
25proline transport (GO:0015824)3.55651184
26positive regulation of synapse assembly (GO:0051965)3.53702950
27protein localization to cilium (GO:0061512)3.52018855
28exploration behavior (GO:0035640)3.48473645
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.41303106
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35273644
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.32980620
32glycosphingolipid biosynthetic process (GO:0006688)3.28907929
33neuron-neuron synaptic transmission (GO:0007270)3.27253676
34pyrimidine nucleobase catabolic process (GO:0006208)3.26574871
35transferrin transport (GO:0033572)3.24931753
36axonal fasciculation (GO:0007413)3.24793361
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24706679
38positive regulation of mitochondrial fission (GO:0090141)3.23916066
39layer formation in cerebral cortex (GO:0021819)3.19328134
40protein polyglutamylation (GO:0018095)3.19178878
41neurofilament cytoskeleton organization (GO:0060052)3.18919851
42regulation of synapse structural plasticity (GO:0051823)3.16910701
43positive regulation of synaptic transmission, GABAergic (GO:0032230)3.16733743
44membrane assembly (GO:0071709)3.15350142
45negative regulation of telomere maintenance (GO:0032205)3.14427129
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.14077658
47sequestering of actin monomers (GO:0042989)3.12980048
48neurotransmitter transport (GO:0006836)3.12771506
49regulation of cAMP-dependent protein kinase activity (GO:2000479)3.11699974
50glutamate receptor signaling pathway (GO:0007215)3.11524333
51energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.10392071
52ATP hydrolysis coupled proton transport (GO:0015991)3.10392071
53synaptic transmission, glutamatergic (GO:0035249)3.10115369
54synapse assembly (GO:0007416)3.09359364
55response to histamine (GO:0034776)3.08415115
56nonmotile primary cilium assembly (GO:0035058)3.08154971
57calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.07937142
58regulation of vesicle fusion (GO:0031338)3.05461378
59retinal ganglion cell axon guidance (GO:0031290)3.05314692
60ferric iron transport (GO:0015682)3.03264480
61trivalent inorganic cation transport (GO:0072512)3.03264480
62cell migration in hindbrain (GO:0021535)3.02690099
63auditory behavior (GO:0031223)3.01327895
64regulation of long-term neuronal synaptic plasticity (GO:0048169)3.00439118
65long-term synaptic potentiation (GO:0060291)3.00328200
66activation of protein kinase A activity (GO:0034199)2.98712796
67negative regulation of neurotransmitter transport (GO:0051589)2.98291720
68regulation of synaptic transmission, glutamatergic (GO:0051966)2.95115781
69dendrite development (GO:0016358)2.93978184
70retinal cone cell development (GO:0046549)2.93802333
71regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93177222
72regulation of neuronal synaptic plasticity (GO:0048168)2.91754923
73regulation of neurotransmitter secretion (GO:0046928)2.91008628
74regulation of neurotransmitter levels (GO:0001505)2.90804393
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90320971
76regulation of glutamate secretion (GO:0014048)2.89035925
77positive regulation of synapse maturation (GO:0090129)2.88820295
78cornea development in camera-type eye (GO:0061303)2.86051694
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85773471
80regulation of synapse assembly (GO:0051963)2.85666923
81negative regulation of dendrite morphogenesis (GO:0050774)2.85364651
82regulation of postsynaptic membrane potential (GO:0060078)2.85114045
83dendritic spine morphogenesis (GO:0060997)2.84957836
84cerebellar granule cell differentiation (GO:0021707)2.83932040
85regulation of feeding behavior (GO:0060259)2.83764861
86startle response (GO:0001964)2.81820486
87mechanosensory behavior (GO:0007638)2.81120746
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81031616
89regulation of synaptic transmission, GABAergic (GO:0032228)2.79888315
90neuronal action potential propagation (GO:0019227)2.77276544
91gamma-aminobutyric acid transport (GO:0015812)2.76921918
92female mating behavior (GO:0060180)2.76146558
93response to auditory stimulus (GO:0010996)2.75312862
94DNA damage response, detection of DNA damage (GO:0042769)2.74882111
95neural tube formation (GO:0001841)2.74116878
96regulation of female receptivity (GO:0045924)2.72906581
97regulation of synapse maturation (GO:0090128)2.72025414
98neuronal action potential (GO:0019228)2.71731347
99dendrite morphogenesis (GO:0048813)2.71598963
100nucleobase catabolic process (GO:0046113)2.71098309
101positive regulation of membrane potential (GO:0045838)2.71009617
102synaptic vesicle transport (GO:0048489)2.70988169
103establishment of synaptic vesicle localization (GO:0097480)2.70988169
104establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.70828019
105mitochondrion transport along microtubule (GO:0047497)2.70828019
106synaptic vesicle endocytosis (GO:0048488)2.70194312
107regulation of neurotransmitter transport (GO:0051588)2.69937521
108positive regulation of neurotransmitter secretion (GO:0001956)2.69830567
109clathrin coat assembly (GO:0048268)2.69147796
110detection of calcium ion (GO:0005513)2.68257556
111positive regulation of neurotransmitter transport (GO:0051590)2.67874332
112regulation of cilium movement (GO:0003352)2.67459559
113vesicle transport along microtubule (GO:0047496)2.66966194
114intraspecies interaction between organisms (GO:0051703)2.65874164
115social behavior (GO:0035176)2.65874164
116transmission of nerve impulse (GO:0019226)2.65451090
117regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.65297975
118inositol phosphate catabolic process (GO:0071545)2.64257184
119regulation of telomere maintenance (GO:0032204)2.63575252
120establishment of vesicle localization (GO:0051650)2.63391744
121hippocampus development (GO:0021766)2.63105205
122regulation of respiratory system process (GO:0044065)2.61552358
123axon extension (GO:0048675)2.61383803
124mating behavior (GO:0007617)2.60301956
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.59521029
126phagosome maturation (GO:0090382)2.59372801
127positive regulation of synaptic transmission (GO:0050806)2.58729257
128synapse organization (GO:0050808)2.58441661
129neuromuscular synaptic transmission (GO:0007274)2.57907285
130kidney morphogenesis (GO:0060993)2.57749553
131positive regulation of dendritic spine morphogenesis (GO:0061003)2.56277147
132central nervous system projection neuron axonogenesis (GO:0021952)2.55253694
133behavioral fear response (GO:0001662)2.54769807
134behavioral defense response (GO:0002209)2.54769807
135protein-cofactor linkage (GO:0018065)2.54231610
136hindbrain development (GO:0030902)2.54120170
137regulation of collateral sprouting (GO:0048670)2.53428494
138fucose catabolic process (GO:0019317)2.53194913
139L-fucose metabolic process (GO:0042354)2.53194913
140L-fucose catabolic process (GO:0042355)2.53194913
141positive regulation of amino acid transport (GO:0051957)2.53021259
142regulation of dendritic spine morphogenesis (GO:0061001)2.52858486
143negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50606683
144short-term memory (GO:0007614)2.50408371
145protein complex biogenesis (GO:0070271)2.48600798
146limb bud formation (GO:0060174)2.47459773
147epithelial cell differentiation involved in kidney development (GO:0035850)2.46445517
148establishment of melanosome localization (GO:0032401)2.45962244
149regulation of development, heterochronic (GO:0040034)2.44087250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.73822918
2GBX2_23144817_ChIP-Seq_PC3_Human3.99020429
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95204517
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74114104
5TAF15_26573619_Chip-Seq_HEK293_Human2.71618892
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63004967
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49647754
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48635933
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46968472
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38923504
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.34643443
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27984051
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27984051
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22967669
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21300319
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20716369
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.18745885
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18356449
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18112611
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16359892
21REST_21632747_ChIP-Seq_MESCs_Mouse2.11978860
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.09367978
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08233252
24AR_21572438_ChIP-Seq_LNCaP_Human2.00013290
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96953484
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.91136735
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.86276573
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85695142
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85523435
30SMAD4_21799915_ChIP-Seq_A2780_Human1.84308656
31P300_19829295_ChIP-Seq_ESCs_Human1.81395233
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80175997
33* EWS_26573619_Chip-Seq_HEK293_Human1.79592377
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78716712
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78250094
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77668980
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77368671
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76636312
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75960918
40IGF1R_20145208_ChIP-Seq_DFB_Human1.75112300
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73311234
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.71785569
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.69730441
44DROSHA_22980978_ChIP-Seq_HELA_Human1.64157692
45* PIAS1_25552417_ChIP-Seq_VCAP_Human1.59641320
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55652674
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.54590639
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52183887
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51561763
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49705948
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49224170
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48869714
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47719118
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45861241
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.45809623
56RNF2_27304074_Chip-Seq_NSC_Mouse1.44412412
57AR_25329375_ChIP-Seq_VCAP_Human1.43146099
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42850595
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42663968
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41583657
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40854852
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39792366
63IRF1_19129219_ChIP-ChIP_H3396_Human1.39414679
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37175138
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.36482571
66RARB_27405468_Chip-Seq_BRAIN_Mouse1.34749181
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34718803
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34718803
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31671491
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30291198
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29477602
72TP53_22573176_ChIP-Seq_HFKS_Human1.28167960
73VDR_22108803_ChIP-Seq_LS180_Human1.25964818
74ER_23166858_ChIP-Seq_MCF-7_Human1.25206440
75AHR_22903824_ChIP-Seq_MCF-7_Human1.24277707
76ZNF274_21170338_ChIP-Seq_K562_Hela1.24104642
77FUS_26573619_Chip-Seq_HEK293_Human1.23554826
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.22127773
79* TP53_18474530_ChIP-ChIP_U2OS_Human1.21262910
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19300499
81* STAT3_23295773_ChIP-Seq_U87_Human1.19180514
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18864079
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16548689
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.15795129
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15681674
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14202581
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13183654
88RUNX2_22187159_ChIP-Seq_PCA_Human1.12998329
89MYC_18940864_ChIP-ChIP_HL60_Human1.12751922
90TCF4_23295773_ChIP-Seq_U87_Human1.11663772
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11623698
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.10545725
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.10249519
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.06884065
95JUN_21703547_ChIP-Seq_K562_Human1.06791487
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.06158571
97ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05694320
98* TAL1_26923725_Chip-Seq_HPCs_Mouse1.05073957
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04799838
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03691423
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.02644632
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02374830
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.01711994
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01241831
105* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01068158
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99923368
107P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99893808
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.99781034
109AR_19668381_ChIP-Seq_PC3_Human0.98247982
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97356000
111TCF4_22108803_ChIP-Seq_LS180_Human0.97286899
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96963042
113KDM2B_26808549_Chip-Seq_REH_Human0.96750503
114NANOG_19829295_ChIP-Seq_ESCs_Human0.95692617
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94841957
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94622871
117E2F1_18555785_Chip-Seq_ESCs_Mouse0.92447516
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.92273482
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.91818769
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91764022
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91571791
122BCAT_22108803_ChIP-Seq_LS180_Human0.90711232
123PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89840415
124VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88890979
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88762190
126P53_22387025_ChIP-Seq_ESCs_Mouse0.88121552
127CBP_20019798_ChIP-Seq_JUKART_Human0.87786147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.73269012
2MP0004859_abnormal_synaptic_plasticity4.28001424
3MP0003635_abnormal_synaptic_transmissio3.49805574
4MP0009780_abnormal_chondrocyte_physiolo3.06070472
5MP0009745_abnormal_behavioral_response2.96807011
6MP0002063_abnormal_learning/memory/cond2.94438037
7MP0004270_analgesia2.87800871
8MP0009046_muscle_twitch2.82832091
9MP0002064_seizures2.81188280
10MP0006276_abnormal_autonomic_nervous2.78593717
11MP0001968_abnormal_touch/_nociception2.77681853
12MP0002572_abnormal_emotion/affect_behav2.61941669
13MP0005423_abnormal_somatic_nervous2.60482854
14MP0002734_abnormal_mechanical_nocicepti2.58109234
15MP0002102_abnormal_ear_morphology2.56403685
16MP0002735_abnormal_chemical_nociception2.41151173
17MP0008877_abnormal_DNA_methylation2.38661286
18MP0005645_abnormal_hypothalamus_physiol2.37203678
19MP0002736_abnormal_nociception_after2.30118391
20MP0001501_abnormal_sleep_pattern2.25865761
21MP0003122_maternal_imprinting2.25108905
22MP0001440_abnormal_grooming_behavior2.19881926
23MP0001529_abnormal_vocalization2.17486569
24MP0002822_catalepsy2.13880428
25MP0002272_abnormal_nervous_system2.08937586
26MP0001486_abnormal_startle_reflex2.03023808
27MP0002733_abnormal_thermal_nociception2.01374762
28MP0000778_abnormal_nervous_system1.93619367
29MP0002067_abnormal_sensory_capabilities1.91575176
30MP0004924_abnormal_behavior1.88527895
31MP0005386_behavior/neurological_phenoty1.88527895
32MP0005646_abnormal_pituitary_gland1.87413472
33MP0001970_abnormal_pain_threshold1.85237043
34MP0002184_abnormal_innervation1.84814757
35MP0001188_hyperpigmentation1.78853604
36MP0003787_abnormal_imprinting1.77902185
37MP0002557_abnormal_social/conspecific_i1.77876089
38MP0006292_abnormal_olfactory_placode1.77323636
39MP0001905_abnormal_dopamine_level1.76889586
40MP0002909_abnormal_adrenal_gland1.73511712
41MP0000013_abnormal_adipose_tissue1.66449424
42MP0002837_dystrophic_cardiac_calcinosis1.64110133
43MP0002653_abnormal_ependyma_morphology1.63051027
44MP0010386_abnormal_urinary_bladder1.60933789
45MP0002876_abnormal_thyroid_physiology1.60809181
46MP0008789_abnormal_olfactory_epithelium1.48494420
47MP0001984_abnormal_olfaction1.48472051
48MP0004811_abnormal_neuron_physiology1.46304048
49MP0004133_heterotaxia1.41061189
50MP0003879_abnormal_hair_cell1.37379893
51MP0002163_abnormal_gland_morphology1.36354793
52MP0005253_abnormal_eye_physiology1.35019348
53MP0004858_abnormal_nervous_system1.34811929
54MP0008569_lethality_at_weaning1.33586544
55MP0003183_abnormal_peptide_metabolism1.24504045
56MP0001502_abnormal_circadian_rhythm1.23921916
57MP0000955_abnormal_spinal_cord1.22639383
58MP0004147_increased_porphyrin_level1.22393632
59MP0002882_abnormal_neuron_morphology1.20836726
60MP0000569_abnormal_digit_pigmentation1.20606400
61MP0002066_abnormal_motor_capabilities/c1.19385336
62MP0001348_abnormal_lacrimal_gland1.19311243
63MP0004142_abnormal_muscle_tone1.17978783
64MP0000751_myopathy1.16565485
65MP0005171_absent_coat_pigmentation1.16028665
66MP0008995_early_reproductive_senescence1.14713706
67MP0005379_endocrine/exocrine_gland_phen1.08449673
68MP0003329_amyloid_beta_deposits1.08088417
69MP0003890_abnormal_embryonic-extraembry1.07884986
70MP0001986_abnormal_taste_sensitivity1.02757697
71MP0003633_abnormal_nervous_system0.99935771
72MP0004272_abnormal_basement_membrane0.94146955
73MP0003119_abnormal_digestive_system0.91996264
74MP0001664_abnormal_digestion0.91690863
75MP0004742_abnormal_vestibular_system0.90149711
76MP0000631_abnormal_neuroendocrine_gland0.89244623
77MP0003631_nervous_system_phenotype0.87315993
78MP0002069_abnormal_eating/drinking_beha0.86917816
79MP0002332_abnormal_exercise_endurance0.86537416
80MP0000049_abnormal_middle_ear0.86260674
81MP0003567_abnormal_fetal_cardiomyocyte0.83790726
82MP0002938_white_spotting0.83678090
83MP0004085_abnormal_heartbeat0.83481284
84MP0002152_abnormal_brain_morphology0.83399415
85MP0002234_abnormal_pharynx_morphology0.83365476
86MP0005535_abnormal_body_temperature0.83124047
87MP0003011_delayed_dark_adaptation0.82867699
88MP0003861_abnormal_nervous_system0.81403275
89MP0000026_abnormal_inner_ear0.81384959
90MP0005623_abnormal_meninges_morphology0.81106683
91MP0008872_abnormal_physiological_respon0.80673125
92MP0005167_abnormal_blood-brain_barrier0.79698972
93MP0001879_abnormal_lymphatic_vessel0.79087649
94MP0004484_altered_response_of0.78445515
95MP0002751_abnormal_autonomic_nervous0.78093949
96MP0001485_abnormal_pinna_reflex0.77971376
97MP0005195_abnormal_posterior_eye0.77894531
98MP0003938_abnormal_ear_development0.76283711
99MP0000681_abnormal_thyroid_gland0.74118896
100MP0001177_atelectasis0.73149424
101MP0002928_abnormal_bile_duct0.71969369
102MP0004043_abnormal_pH_regulation0.70727537
103MP0006035_abnormal_mitochondrial_morpho0.70295652
104MP0000538_abnormal_urinary_bladder0.68671498
105MP0001963_abnormal_hearing_physiology0.67935595
106MP0002138_abnormal_hepatobiliary_system0.67891625
107MP0003137_abnormal_impulse_conducting0.67771613
108MP0005187_abnormal_penis_morphology0.67557457
109MP0005394_taste/olfaction_phenotype0.67318385
110MP0005499_abnormal_olfactory_system0.67318385
111MP0002752_abnormal_somatic_nervous0.65659997
112MP0001299_abnormal_eye_distance/0.64981225
113MP0001943_abnormal_respiration0.64002794
114MP0003121_genomic_imprinting0.62118861
115* MP0003634_abnormal_glial_cell0.60505411
116MP0002229_neurodegeneration0.60375982
117MP0004215_abnormal_myocardial_fiber0.59872660
118MP0005551_abnormal_eye_electrophysiolog0.59593339
119MP0008874_decreased_physiological_sensi0.59544261
120MP0003045_fibrosis0.59328004
121MP0005084_abnormal_gallbladder_morpholo0.58875074
122MP0002638_abnormal_pupillary_reflex0.58697949
123MP0004885_abnormal_endolymph0.57628207
124MP0002090_abnormal_vision0.56773476
125MP0004883_abnormal_blood_vessel0.55719619
126MP0000230_abnormal_systemic_arterial0.55037961
127MP0006072_abnormal_retinal_apoptosis0.54625128
128MP0003632_abnormal_nervous_system0.54167216

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.06007410
2Atonic seizures (HP:0010819)5.04722121
3Focal seizures (HP:0007359)4.69564373
4Epileptic encephalopathy (HP:0200134)4.68582119
5Limb dystonia (HP:0002451)4.43796841
6Myokymia (HP:0002411)4.33660444
7Febrile seizures (HP:0002373)4.26355433
8Visual hallucinations (HP:0002367)4.00529504
9Hyperventilation (HP:0002883)3.92901683
10Pheochromocytoma (HP:0002666)3.88066248
11Abnormal hair whorl (HP:0010721)3.84976290
12Absence seizures (HP:0002121)3.80510497
13Polyphagia (HP:0002591)3.79101436
14Neuroendocrine neoplasm (HP:0100634)3.68730575
15Progressive cerebellar ataxia (HP:0002073)3.60757754
16Failure to thrive in infancy (HP:0001531)3.47810235
17Dialeptic seizures (HP:0011146)3.41522757
18Generalized tonic-clonic seizures (HP:0002069)3.34762784
19Progressive inability to walk (HP:0002505)3.33475501
20Broad-based gait (HP:0002136)3.30041928
21Abnormal eating behavior (HP:0100738)3.08792979
22Hypothermia (HP:0002045)3.08283728
23Gait imbalance (HP:0002141)3.06158804
24Pancreatic cysts (HP:0001737)3.00332908
25True hermaphroditism (HP:0010459)2.99146626
26Hypoventilation (HP:0002791)2.98082647
27Excessive salivation (HP:0003781)2.96864787
28Drooling (HP:0002307)2.96864787
29Ankle clonus (HP:0011448)2.90086811
30Retinal dysplasia (HP:0007973)2.85312879
31Molar tooth sign on MRI (HP:0002419)2.83923935
32Abnormality of midbrain morphology (HP:0002418)2.83923935
33Pancreatic fibrosis (HP:0100732)2.82736844
34Mutism (HP:0002300)2.78126011
35Nephronophthisis (HP:0000090)2.76189669
36Hyperthyroidism (HP:0000836)2.75524617
37Akinesia (HP:0002304)2.70022237
38Type II lissencephaly (HP:0007260)2.65897544
39Pachygyria (HP:0001302)2.65180942
40Supranuclear gaze palsy (HP:0000605)2.63688324
41Agitation (HP:0000713)2.63336106
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.61249530
43Oligomenorrhea (HP:0000876)2.60312510
44Amblyopia (HP:0000646)2.58188510
45Inability to walk (HP:0002540)2.57577622
46Abnormality of binocular vision (HP:0011514)2.57375797
47Diplopia (HP:0000651)2.57375797
48Epileptiform EEG discharges (HP:0011182)2.56690111
49Blue irides (HP:0000635)2.55665809
50Anxiety (HP:0000739)2.51524794
51Truncal ataxia (HP:0002078)2.46530476
52Medial flaring of the eyebrow (HP:0010747)2.46295737
53Protruding tongue (HP:0010808)2.46024164
54Fetal akinesia sequence (HP:0001989)2.44847168
55EEG with generalized epileptiform discharges (HP:0011198)2.44067302
56Specific learning disability (HP:0001328)2.39176595
57Papilledema (HP:0001085)2.38855228
58Poor suck (HP:0002033)2.38542475
59Congenital primary aphakia (HP:0007707)2.38446781
60Cortical dysplasia (HP:0002539)2.36533087
61Narrow nasal bridge (HP:0000446)2.36372389
62Hypsarrhythmia (HP:0002521)2.32875550
63Congenital stationary night blindness (HP:0007642)2.29658610
64Abnormality of calcium-phosphate metabolism (HP:0100530)2.29628274
65Nephrogenic diabetes insipidus (HP:0009806)2.29386111
66Poor eye contact (HP:0000817)2.29246953
67Spastic tetraplegia (HP:0002510)2.27972869
68Abnormality of the corticospinal tract (HP:0002492)2.27638051
69Exotropia (HP:0000577)2.26124604
70Abnormality of salivation (HP:0100755)2.25640315
71Depression (HP:0000716)2.21541532
72Abnormality of the renal medulla (HP:0100957)2.21299124
73Growth hormone excess (HP:0000845)2.20676720
74Impaired vibration sensation in the lower limbs (HP:0002166)2.16596528
75Absent speech (HP:0001344)2.14430731
76Intestinal atresia (HP:0011100)2.13297298
77Gaze-evoked nystagmus (HP:0000640)2.13234131
78Action tremor (HP:0002345)2.11679224
79Genital tract atresia (HP:0001827)2.11016223
80Genetic anticipation (HP:0003743)2.10839603
81Cerebral inclusion bodies (HP:0100314)2.09778999
82Vaginal atresia (HP:0000148)2.08539104
83Neurofibrillary tangles (HP:0002185)2.07981963
84Methylmalonic acidemia (HP:0002912)2.07973625
85Abolished electroretinogram (ERG) (HP:0000550)2.06291277
86Esotropia (HP:0000565)2.05688648
87Sleep apnea (HP:0010535)2.04177315
88Abnormal social behavior (HP:0012433)2.02384639
89Impaired social interactions (HP:0000735)2.02384639
90Optic nerve hypoplasia (HP:0000609)2.02077348
91Cerebral hemorrhage (HP:0001342)2.02054883
92Lower limb muscle weakness (HP:0007340)2.00801075
93Neoplasm of the peripheral nervous system (HP:0100007)2.00059794
94Insidious onset (HP:0003587)1.99749938
95Termporal pattern (HP:0011008)1.99749938
96Muscular hypotonia of the trunk (HP:0008936)1.99439927
97Urinary bladder sphincter dysfunction (HP:0002839)1.97261035
98Hemiparesis (HP:0001269)1.96967295
99Atrophy/Degeneration involving motor neurons (HP:0007373)1.95913659
100Lissencephaly (HP:0001339)1.95372201
101Degeneration of the lateral corticospinal tracts (HP:0002314)1.94824257
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94824257
103Sclerocornea (HP:0000647)1.94490440
104Progressive macrocephaly (HP:0004481)1.91979103
105Acute necrotizing encephalopathy (HP:0006965)1.91639643
106Mitochondrial inheritance (HP:0001427)1.90375336
107Hypercortisolism (HP:0001578)1.89777466
108Morphological abnormality of the pyramidal tract (HP:0002062)1.88558421
109Menstrual irregularities (HP:0000858)1.87870849
110Amyotrophic lateral sclerosis (HP:0007354)1.86908815
111Poor coordination (HP:0002370)1.86433608
112Open mouth (HP:0000194)1.85460559
113Acute encephalopathy (HP:0006846)1.85345673
114Narrow forehead (HP:0000341)1.85089212
115Urinary urgency (HP:0000012)1.85067713
116Cystic liver disease (HP:0006706)1.84294021
117Rimmed vacuoles (HP:0003805)1.83525542
118Oligodactyly (hands) (HP:0001180)1.83132953
119Torticollis (HP:0000473)1.82877408
120Postaxial hand polydactyly (HP:0001162)1.82609724
1213-Methylglutaconic aciduria (HP:0003535)1.82317345
122Thyroid-stimulating hormone excess (HP:0002925)1.81615984
123Ulnar claw (HP:0001178)1.80996182
124Hypoplasia of the brainstem (HP:0002365)1.80916923
125Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80916923
126Dysdiadochokinesis (HP:0002075)1.80479496
127Bradykinesia (HP:0002067)1.80413620
128Increased CSF lactate (HP:0002490)1.79181754
129Abnormal mitochondria in muscle tissue (HP:0008316)1.78496005
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78051724
131Bradycardia (HP:0001662)1.78037829
132Status epilepticus (HP:0002133)1.77825400
133Abnormality of the renal cortex (HP:0011035)1.77793326
134Abnormality of the labia minora (HP:0012880)1.77124643
135Methylmalonic aciduria (HP:0012120)1.77097356
136Aplasia/Hypoplasia of the lens (HP:0008063)1.76971854
137Anencephaly (HP:0002323)1.76417185
138Spastic gait (HP:0002064)1.76399307
139Labial hypoplasia (HP:0000066)1.74543896
140Hip dysplasia (HP:0001385)1.74507745
141Dyskinesia (HP:0100660)1.74191257
142Dysmetria (HP:0001310)1.73835228
143Incomplete penetrance (HP:0003829)1.73556658
144Hepatocellular necrosis (HP:0001404)1.73214580
145Hepatic necrosis (HP:0002605)1.72766460
146Broad foot (HP:0001769)1.72617130
147Pendular nystagmus (HP:0012043)1.71056706
148Generalized myoclonic seizures (HP:0002123)1.69027655
149Colon cancer (HP:0003003)1.67447618

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.02427076
2MARK14.29182853
3MAP3K123.47098026
4NTRK33.19749867
5MAP4K23.15074022
6MAP2K72.95361098
7MAP3K42.78090087
8TRIM282.72079649
9MAP3K92.40121326
10NTRK22.15460992
11MINK12.12619439
12PLK22.02719259
13DAPK21.97451360
14MAPK131.91428124
15GRK11.78089486
16PINK11.74809220
17BCKDK1.73568360
18MAP2K41.72275059
19AKT31.72180164
20EPHA41.67572078
21BCR1.67255101
22ERBB31.64255971
23SIK31.57634559
24CSNK1A1L1.55133038
25GRK51.50308666
26CDK191.47953863
27CCNB11.38324751
28DAPK11.35806187
29TIE11.28888713
30PHKG11.26054042
31PHKG21.26054042
32OXSR11.21446229
33BMPR1B1.19856247
34CDK51.19206696
35SGK21.15112502
36SGK2231.13099193
37SGK4941.13099193
38TGFBR11.11997709
39DYRK31.09577559
40PRPF4B1.08034468
41TSSK61.02517058
42PRKCG1.02462302
43PAK61.02440907
44PRKCE1.02094000
45WNK31.01778611
46NTRK11.00613892
47CAMK2A0.99613361
48GRK70.97984031
49DYRK20.97871056
50KSR10.96627731
51CSNK1G20.95355660
52TNIK0.92770721
53SIK20.89015351
54LIMK10.88017914
55PKN10.87527744
56PAK30.86934877
57BMPR20.86368903
58UHMK10.85602818
59ZAK0.85464780
60MYLK0.84518409
61RPS6KA40.82313201
62ADRBK20.80719672
63SRPK10.80422783
64DYRK1A0.78569854
65MKNK20.78405753
66ARAF0.76752682
67PNCK0.75525903
68FER0.74233577
69ADRBK10.73850447
70PTK2B0.72259380
71RPS6KA20.70109309
72MAP3K140.69294730
73EPHB20.69041583
74PRKCH0.67032594
75KSR20.66419759
76LATS20.65871171
77CAMK2B0.65390409
78CDK140.64795783
79CDK180.64185377
80SGK30.64103015
81CSNK1G30.63410100
82CDK80.62385200
83RET0.61513570
84INSRR0.61100983
85WNK40.60633914
86MAP3K20.59371469
87PLK30.58295081
88TAOK30.57924819
89MKNK10.57632304
90CAMKK20.57063350
91FRK0.56704929
92CDK150.55726824
93EPHA30.54757909
94FES0.54521876
95DYRK1B0.54308067
96MAP3K130.53865775
97CAMK40.53654414
98SGK10.53653682
99NUAK10.52067989
100CSNK1A10.51489304
101NME10.51169043
102MARK20.48112593
103PRKACA0.46224502
104RPS6KA50.46100033
105PRKD30.44500093
106NEK10.44240785
107CDK11A0.43542012
108CSNK1D0.43401653
109MAPK120.43269473
110STK390.43055889
111VRK10.42629361
112MAP2K10.40798709
113RIPK40.40201350
114CAMK10.38769150
115PRKCZ0.38622061
116ROCK10.37913452
117TESK10.37767885
118CAMK2D0.37477421
119ERBB40.37391484
120MAP3K10.37388949
121FGFR20.37218662
122PRKAA10.37217174
123STK110.36368828
124FYN0.36038408
125CAMKK10.35882473
126PRKACB0.35246634
127CSNK1E0.34988868
128MAPK150.34823123
129STK160.33863035
130MAPKAPK50.33445330
131ROCK20.32475493
132CSNK1G10.32425346
133PRKG10.29950493
134STK38L0.28962144
135PRKCA0.28806237
136FLT30.26906443

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.52113413
2Nicotine addiction_Homo sapiens_hsa050333.33533524
3Collecting duct acid secretion_Homo sapiens_hsa049662.84537678
4Protein export_Homo sapiens_hsa030602.46546351
5GABAergic synapse_Homo sapiens_hsa047272.36145668
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34108081
7Morphine addiction_Homo sapiens_hsa050322.21263613
8Circadian entrainment_Homo sapiens_hsa047132.13069671
9Butanoate metabolism_Homo sapiens_hsa006502.10731101
10Vibrio cholerae infection_Homo sapiens_hsa051102.06095482
11Amphetamine addiction_Homo sapiens_hsa050312.02412251
12Olfactory transduction_Homo sapiens_hsa047401.97059938
13Dopaminergic synapse_Homo sapiens_hsa047281.90620898
14Glutamatergic synapse_Homo sapiens_hsa047241.84747264
15Long-term potentiation_Homo sapiens_hsa047201.80760141
16Cocaine addiction_Homo sapiens_hsa050301.79868297
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75943511
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.75658289
19Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.75451024
20Serotonergic synapse_Homo sapiens_hsa047261.73768600
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73399967
22Cholinergic synapse_Homo sapiens_hsa047251.68545212
23Taste transduction_Homo sapiens_hsa047421.67255620
24Insulin secretion_Homo sapiens_hsa049111.66753894
25Type I diabetes mellitus_Homo sapiens_hsa049401.63487568
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61620965
27Rheumatoid arthritis_Homo sapiens_hsa053231.58481333
28Renin secretion_Homo sapiens_hsa049241.55866774
29Salivary secretion_Homo sapiens_hsa049701.52699260
30Long-term depression_Homo sapiens_hsa047301.49137294
31Oxidative phosphorylation_Homo sapiens_hsa001901.45729456
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43815710
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35946535
34Axon guidance_Homo sapiens_hsa043601.35672283
35Basal transcription factors_Homo sapiens_hsa030221.34813133
36Gastric acid secretion_Homo sapiens_hsa049711.32606892
37Regulation of autophagy_Homo sapiens_hsa041401.31613575
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27313566
39Ether lipid metabolism_Homo sapiens_hsa005651.23555299
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23248464
41Steroid biosynthesis_Homo sapiens_hsa001001.23193820
42Oxytocin signaling pathway_Homo sapiens_hsa049211.23101746
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21459727
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21184446
45Calcium signaling pathway_Homo sapiens_hsa040201.17310771
46Gap junction_Homo sapiens_hsa045401.13207142
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12784212
48Selenocompound metabolism_Homo sapiens_hsa004501.12479177
49Phagosome_Homo sapiens_hsa041451.08813510
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07343275
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05639088
52Linoleic acid metabolism_Homo sapiens_hsa005911.05485448
53RNA degradation_Homo sapiens_hsa030181.05341340
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03313333
55Parkinsons disease_Homo sapiens_hsa050121.02708327
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01622614
57Propanoate metabolism_Homo sapiens_hsa006401.00519119
58Alzheimers disease_Homo sapiens_hsa050100.99219807
59Tryptophan metabolism_Homo sapiens_hsa003800.97892890
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97886592
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97370192
62ErbB signaling pathway_Homo sapiens_hsa040120.94952103
63cAMP signaling pathway_Homo sapiens_hsa040240.94263295
64GnRH signaling pathway_Homo sapiens_hsa049120.93735563
65Estrogen signaling pathway_Homo sapiens_hsa049150.91002213
66Type II diabetes mellitus_Homo sapiens_hsa049300.88771619
67Peroxisome_Homo sapiens_hsa041460.87077320
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.86978650
69RNA polymerase_Homo sapiens_hsa030200.82212438
70Cardiac muscle contraction_Homo sapiens_hsa042600.81150293
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79698341
72Melanogenesis_Homo sapiens_hsa049160.79664126
73Dilated cardiomyopathy_Homo sapiens_hsa054140.78699419
74Fatty acid elongation_Homo sapiens_hsa000620.77045984
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76509953
76Allograft rejection_Homo sapiens_hsa053300.75973669
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73655127
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72972541
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72744591
80Dorso-ventral axis formation_Homo sapiens_hsa043200.72727075
81MAPK signaling pathway_Homo sapiens_hsa040100.72436238
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72287062
83Ras signaling pathway_Homo sapiens_hsa040140.72134704
84Phototransduction_Homo sapiens_hsa047440.71772601
85African trypanosomiasis_Homo sapiens_hsa051430.70579739
86Non-homologous end-joining_Homo sapiens_hsa034500.70221855
87Glioma_Homo sapiens_hsa052140.68483230
88Graft-versus-host disease_Homo sapiens_hsa053320.68221863
89Nitrogen metabolism_Homo sapiens_hsa009100.68020707
90Renal cell carcinoma_Homo sapiens_hsa052110.66651226
91beta-Alanine metabolism_Homo sapiens_hsa004100.65372092
92Autoimmune thyroid disease_Homo sapiens_hsa053200.64681964
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61453298
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58860900
95Oocyte meiosis_Homo sapiens_hsa041140.57905448
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56892073
97Fanconi anemia pathway_Homo sapiens_hsa034600.55062536
98Chemokine signaling pathway_Homo sapiens_hsa040620.54375787
99Huntingtons disease_Homo sapiens_hsa050160.54345231
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52948035
101Prion diseases_Homo sapiens_hsa050200.52727934
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52364139
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.50188357
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.49589220
105Rap1 signaling pathway_Homo sapiens_hsa040150.48947872
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47209373
107Prolactin signaling pathway_Homo sapiens_hsa049170.47098814
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46489063
109Endometrial cancer_Homo sapiens_hsa052130.46461954
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46095238
111Vitamin B6 metabolism_Homo sapiens_hsa007500.45296215
112Thyroid hormone synthesis_Homo sapiens_hsa049180.44833230
113Metabolic pathways_Homo sapiens_hsa011000.44806553
114Endocytosis_Homo sapiens_hsa041440.43687570
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43336501
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.43152589
117Pancreatic secretion_Homo sapiens_hsa049720.41761777
118Ovarian steroidogenesis_Homo sapiens_hsa049130.41632071
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41033976
120Hedgehog signaling pathway_Homo sapiens_hsa043400.40772381
121Colorectal cancer_Homo sapiens_hsa052100.40576030
122Caffeine metabolism_Homo sapiens_hsa002320.40225145
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40051659
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39532075
125Alcoholism_Homo sapiens_hsa050340.38805565
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.38678468
127Choline metabolism in cancer_Homo sapiens_hsa052310.37483227
128Salmonella infection_Homo sapiens_hsa051320.37471601
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37272835
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37197875
131Viral myocarditis_Homo sapiens_hsa054160.36203099
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35563013
133Fatty acid metabolism_Homo sapiens_hsa012120.35550805
134Wnt signaling pathway_Homo sapiens_hsa043100.35011965
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34775206
136Circadian rhythm_Homo sapiens_hsa047100.33909543
137Inositol phosphate metabolism_Homo sapiens_hsa005620.33857064
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.33743838
139Melanoma_Homo sapiens_hsa052180.32054112
140Proteasome_Homo sapiens_hsa030500.31238611
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30523858
142Hippo signaling pathway_Homo sapiens_hsa043900.30083682
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29860650
144Glucagon signaling pathway_Homo sapiens_hsa049220.29258859
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27562432
146Purine metabolism_Homo sapiens_hsa002300.26261061
147Arginine and proline metabolism_Homo sapiens_hsa003300.22093653

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