CD200R1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.49643105
2cilium or flagellum-dependent cell motility (GO:0001539)6.74165567
3cellular response to electrical stimulus (GO:0071257)6.40716494
4DNA deamination (GO:0045006)6.21659730
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.10473689
6cytidine deamination (GO:0009972)6.02012474
7cytidine metabolic process (GO:0046087)6.02012474
8cytidine catabolic process (GO:0006216)6.02012474
9cilium movement (GO:0003341)5.60492234
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.29081591
11pyrimidine ribonucleoside catabolic process (GO:0046133)5.28813524
12regulation of cilium movement (GO:0003352)5.19603981
13G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.16917071
14cerebellar Purkinje cell differentiation (GO:0021702)5.09890931
15epithelial cilium movement (GO:0003351)4.96060855
16motile cilium assembly (GO:0044458)4.70936031
17axoneme assembly (GO:0035082)4.70276922
18cellular response to interleukin-15 (GO:0071350)4.45664739
19endoderm formation (GO:0001706)4.29473264
20response to interleukin-15 (GO:0070672)4.26256363
21regulation of microtubule-based movement (GO:0060632)4.25224588
22regulation of T cell mediated cytotoxicity (GO:0001914)4.24686705
23regulation of memory T cell differentiation (GO:0043380)4.23920955
24somite rostral/caudal axis specification (GO:0032525)4.13768355
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.13740336
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.13740336
27activated T cell proliferation (GO:0050798)4.11565775
28positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.97040678
29regulation of regulatory T cell differentiation (GO:0045589)3.79525640
30positive regulation of defense response to virus by host (GO:0002230)3.74815010
31regulation of leukocyte mediated cytotoxicity (GO:0001910)3.65552721
32negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.61927009
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.57248451
34negative regulation of cell killing (GO:0031342)3.57248451
35positive regulation of T cell mediated cytotoxicity (GO:0001916)3.47296531
36positive T cell selection (GO:0043368)3.46103840
37negative regulation by host of viral transcription (GO:0043922)3.43959076
38vagina development (GO:0060068)3.43382703
39regulation of cell killing (GO:0031341)3.43351532
40sequestering of actin monomers (GO:0042989)3.42268166
41negative regulation of T-helper cell differentiation (GO:0045623)3.39769902
42negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.39769902
43preassembly of GPI anchor in ER membrane (GO:0016254)3.39663269
44regulation of sensory perception of pain (GO:0051930)3.37422667
45regulation of sensory perception (GO:0051931)3.37422667
46diterpenoid biosynthetic process (GO:0016102)3.34373826
47regulation of chronic inflammatory response (GO:0002676)3.34344398
48glomerulus development (GO:0032835)3.32758360
49cellular response to interferon-beta (GO:0035458)3.29641735
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.25666202
51positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.25152630
52sodium-independent organic anion transport (GO:0043252)3.18664644
53kidney morphogenesis (GO:0060993)3.12621173
54regulation of germinal center formation (GO:0002634)3.11338970
55head development (GO:0060322)3.00556559
56positive regulation of cell killing (GO:0031343)2.99580994
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98368059
58left/right axis specification (GO:0070986)2.96801323
59negative regulation of T cell apoptotic process (GO:0070233)2.95633807
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.92861452
61regulation of T-helper 1 type immune response (GO:0002825)2.92749249
62detection of light stimulus involved in sensory perception (GO:0050962)2.90554280
63detection of light stimulus involved in visual perception (GO:0050908)2.90554280
64positive regulation of T cell differentiation in thymus (GO:0033089)2.90454261
65positive regulation of natural killer cell mediated immunity (GO:0002717)2.87254062
66pyrimidine nucleoside catabolic process (GO:0046135)2.85695679
67negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.84389433
68negative regulation of adaptive immune response (GO:0002820)2.84345248
69protein-cofactor linkage (GO:0018065)2.80753175
70response to pheromone (GO:0019236)2.79521802
71positive thymic T cell selection (GO:0045059)2.79478364
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79071155
73necroptotic process (GO:0070266)2.77707245
74retinal metabolic process (GO:0042574)2.77237877
75positive regulation of gastrulation (GO:2000543)2.73515976
76negative regulation of T cell mediated immunity (GO:0002710)2.73366046
77tolerance induction (GO:0002507)2.72997127
78regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.72980820
79regulation of natural killer cell mediated immunity (GO:0002715)2.72980820
80negative regulation of T cell differentiation in thymus (GO:0033085)2.69681807
81positive regulation of T cell cytokine production (GO:0002726)2.69076183
82regulation of T cell apoptotic process (GO:0070232)2.68149992
83metallo-sulfur cluster assembly (GO:0031163)2.67613542
84iron-sulfur cluster assembly (GO:0016226)2.67613542
85positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.67403047
86negative regulation of multicellular organism growth (GO:0040015)2.66852675
87antigen processing and presentation of endogenous antigen (GO:0019883)2.64074007
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.62106585
89regulation of interleukin-8 secretion (GO:2000482)2.60989180
90spinal cord association neuron differentiation (GO:0021527)2.60318093
91regulation of T cell mediated immunity (GO:0002709)2.59555196
92negative regulation of alpha-beta T cell differentiation (GO:0046639)2.59381383
93positive regulation of calcium-mediated signaling (GO:0050850)2.58008631
94response to xenobiotic stimulus (GO:0009410)2.54860884
95regulation of defense response to virus by host (GO:0050691)2.54191494
96cell differentiation in spinal cord (GO:0021515)2.53351781
97lymph node development (GO:0048535)2.52064531
98eosinophil chemotaxis (GO:0048245)2.51132825
99regulation of activation of Janus kinase activity (GO:0010533)2.51084514
100response to gravity (GO:0009629)2.50947583

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.12769861
2VDR_22108803_ChIP-Seq_LS180_Human3.74070196
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.24858225
4ZNF274_21170338_ChIP-Seq_K562_Hela3.23979910
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.96636478
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.85319825
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.70499577
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66185347
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38472082
10GBX2_23144817_ChIP-Seq_PC3_Human2.25299642
11EZH2_22144423_ChIP-Seq_EOC_Human2.19032303
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.08996849
13IGF1R_20145208_ChIP-Seq_DFB_Human2.05215694
14ER_23166858_ChIP-Seq_MCF-7_Human1.96177010
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83863980
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72470697
17AR_21572438_ChIP-Seq_LNCaP_Human1.70900241
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70413189
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70078061
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69953491
21GATA3_26560356_Chip-Seq_TH2_Human1.65930721
22RUNX_20019798_ChIP-Seq_JUKART_Human1.64555456
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.64373857
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.63348732
25CBP_20019798_ChIP-Seq_JUKART_Human1.55919355
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55919355
27TAF15_26573619_Chip-Seq_HEK293_Human1.49266074
28MYB_26560356_Chip-Seq_TH2_Human1.44734810
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43023098
30FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42460664
31FOXA1_25329375_ChIP-Seq_VCAP_Human1.42460664
32TAF2_19829295_ChIP-Seq_ESCs_Human1.42310495
33GATA3_27048872_Chip-Seq_THYMUS_Human1.39258606
34PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.39165552
35GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.39097348
36TP53_22573176_ChIP-Seq_HFKS_Human1.37858122
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37075575
38DROSHA_22980978_ChIP-Seq_HELA_Human1.34499622
39OCT4_20526341_ChIP-Seq_ESCs_Human1.34193918
40ERA_21632823_ChIP-Seq_H3396_Human1.34189471
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34160780
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32953203
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31614291
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31261480
45BCAT_22108803_ChIP-Seq_LS180_Human1.31112533
46* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.30426505
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29885072
48TDRD3_21172665_ChIP-Seq_MCF-7_Human1.26225477
49P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.26104366
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24647482
51PRDM14_20953172_ChIP-Seq_ESCs_Human1.23816376
52* NANOG_20526341_ChIP-Seq_ESCs_Human1.22056713
53HOXB7_26014856_ChIP-Seq_BT474_Human1.20791876
54SOX2_19829295_ChIP-Seq_ESCs_Human1.19316979
55NANOG_19829295_ChIP-Seq_ESCs_Human1.19316979
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.19231727
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19002926
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.18807211
59TCF4_23295773_ChIP-Seq_U87_Human1.18067917
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.17999219
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17397251
62RAC3_21632823_ChIP-Seq_H3396_Human1.17325650
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16664158
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15153349
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14462802
66CEBPB_22108803_ChIP-Seq_LS180_Human1.14257574
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13711699
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12958124
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12467550
70TCF4_22108803_ChIP-Seq_LS180_Human1.12451281
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12011585
72NCOR_22424771_ChIP-Seq_293T_Human1.10509860
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10466000
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10091848
75RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09409120
76AR_20517297_ChIP-Seq_VCAP_Human1.09204055
77ERG_20517297_ChIP-Seq_VCAP_Human1.07975004
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07907744
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07355928
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06546534
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05740707
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04589772
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03512647
84YY1_22570637_ChIP-Seq_MALME-3M_Human1.03480939
85SMAD3_21741376_ChIP-Seq_HESCs_Human1.02156898
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01883907
87SMAD4_21799915_ChIP-Seq_A2780_Human1.00163533
88P53_21459846_ChIP-Seq_SAOS-2_Human0.99876799
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99635183
90CTCF_18555785_Chip-Seq_ESCs_Mouse0.99181594
91MYB_26560356_Chip-Seq_TH1_Human0.98866085
92STAT1_20625510_ChIP-Seq_HELA_Human0.98000631
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97771516
94SMRT_27268052_Chip-Seq_Bcells_Human0.97719633
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96078146
96CTCF_20526341_ChIP-Seq_ESCs_Human0.95987770
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95535197
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95415068
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95162806
100* STAT3_23295773_ChIP-Seq_U87_Human0.93154076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.37723443
2MP0003283_abnormal_digestive_organ3.73239687
3MP0002736_abnormal_nociception_after3.02300879
4MP0004147_increased_porphyrin_level2.70331895
5MP0005377_hearing/vestibular/ear_phenot2.61287064
6MP0003878_abnormal_ear_physiology2.61287064
7MP0001968_abnormal_touch/_nociception2.60157505
8MP0003252_abnormal_bile_duct2.59142314
9MP0001984_abnormal_olfaction2.07544504
10MP0001501_abnormal_sleep_pattern2.02809688
11MP0008875_abnormal_xenobiotic_pharmacok2.02365451
12MP0003763_abnormal_thymus_physiology1.99172943
13MP0005000_abnormal_immune_tolerance1.96349443
14MP0001835_abnormal_antigen_presentation1.96192158
15MP0005386_behavior/neurological_phenoty1.92710720
16MP0004924_abnormal_behavior1.92710720
17MP0009046_muscle_twitch1.88623525
18MP0000372_irregular_coat_pigmentation1.87575652
19MP0004043_abnormal_pH_regulation1.87514725
20MP0003890_abnormal_embryonic-extraembry1.87394286
21MP0009785_altered_susceptibility_to1.84188895
22MP0002723_abnormal_immune_serum1.81437371
23MP0001800_abnormal_humoral_immune1.80906055
24MP0002653_abnormal_ependyma_morphology1.78125170
25MP0003436_decreased_susceptibility_to1.73985798
26MP0005645_abnormal_hypothalamus_physiol1.70600161
27MP0001819_abnormal_immune_cell1.67760943
28MP0002420_abnormal_adaptive_immunity1.63758742
29MP0006082_CNS_inflammation1.62510789
30MP0008995_early_reproductive_senescence1.60785317
31MP0002452_abnormal_antigen_presenting1.60600548
32MP0005551_abnormal_eye_electrophysiolog1.58421500
33MP0002148_abnormal_hypersensitivity_rea1.57247009
34MP0003866_abnormal_defecation1.55029150
35MP0008789_abnormal_olfactory_epithelium1.50635464
36MP0002557_abnormal_social/conspecific_i1.50240679
37MP0002132_abnormal_respiratory_system1.50191151
38MP0010155_abnormal_intestine_physiology1.46966520
39MP0002933_joint_inflammation1.46245586
40MP0005025_abnormal_response_to1.45150447
41MP0002139_abnormal_hepatobiliary_system1.43285156
42MP0005387_immune_system_phenotype1.41864188
43MP0001790_abnormal_immune_system1.41864188
44MP0008877_abnormal_DNA_methylation1.37508333
45MP0005253_abnormal_eye_physiology1.35903435
46MP0001765_abnormal_ion_homeostasis1.34578871
47MP0003724_increased_susceptibility_to1.34146728
48MP0002419_abnormal_innate_immunity1.32038917
49MP0001986_abnormal_taste_sensitivity1.31009742
50MP0003195_calcinosis1.30062725
51MP0004885_abnormal_endolymph1.29008351
52MP0002735_abnormal_chemical_nociception1.27419336
53MP0001529_abnormal_vocalization1.25225881
54MP0005310_abnormal_salivary_gland1.24752809
55MP0005410_abnormal_fertilization1.24320351
56MP0002272_abnormal_nervous_system1.22884644
57MP0005647_abnormal_sex_gland1.21462886
58MP0005636_abnormal_mineral_homeostasis1.18258748
59MP0002693_abnormal_pancreas_physiology1.18075496
60MP0003646_muscle_fatigue1.15464471
61MP0005083_abnormal_biliary_tract1.13540017
62MP0000685_abnormal_immune_system1.13059742
63MP0001486_abnormal_startle_reflex1.11554004
64MP0001970_abnormal_pain_threshold1.11200790
65MP0000716_abnormal_immune_system1.08972663
66MP0002733_abnormal_thermal_nociception1.08809432
67MP0002572_abnormal_emotion/affect_behav1.08084766
68MP0003806_abnormal_nucleotide_metabolis1.07612316
69MP0002398_abnormal_bone_marrow1.06714941
70MP0004742_abnormal_vestibular_system1.04590874
71MP0008872_abnormal_physiological_respon1.03483763
72MP0002876_abnormal_thyroid_physiology0.99584067
73MP0009333_abnormal_splenocyte_physiolog0.99510406
74MP0002067_abnormal_sensory_capabilities0.99237088
75MP0005389_reproductive_system_phenotype0.99004985
76MP0009764_decreased_sensitivity_to0.98811240
77MP0000689_abnormal_spleen_morphology0.96249875
78MP0002734_abnormal_mechanical_nocicepti0.95631274
79MP0001533_abnormal_skeleton_physiology0.95193336
80MP0001845_abnormal_inflammatory_respons0.95015921
81MP0010329_abnormal_lipoprotein_level0.93771059
82MP0003698_abnormal_male_reproductive0.92555793
83MP0001919_abnormal_reproductive_system0.89890073
84MP0001929_abnormal_gametogenesis0.88894442
85MP0004019_abnormal_vitamin_homeostasis0.88729237
86MP0001119_abnormal_female_reproductive0.86915010
87MP0001485_abnormal_pinna_reflex0.86274175
88MP0000703_abnormal_thymus_morphology0.85958293
89MP0002722_abnormal_immune_system0.85222237
90MP0009745_abnormal_behavioral_response0.84569157
91MP0002277_abnormal_respiratory_mucosa0.83506076
92MP0003638_abnormal_response/metabolism_0.83076871
93MP0005167_abnormal_blood-brain_barrier0.82722299
94MP0002429_abnormal_blood_cell0.81790291
95MP0004947_skin_inflammation0.81128476
96MP0001853_heart_inflammation0.80646675
97MP0008469_abnormal_protein_level0.76666585
98MP0008874_decreased_physiological_sensi0.74167853
99MP0001661_extended_life_span0.74043281
100MP0001944_abnormal_pancreas_morphology0.70183889

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.76642843
2Absent/shortened dynein arms (HP:0200106)7.21442392
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.21442392
4Abnormal respiratory motile cilium physiology (HP:0012261)6.95370914
5Abnormal respiratory motile cilium morphology (HP:0005938)6.20503303
6Abnormal respiratory epithelium morphology (HP:0012253)6.20503303
7Abnormal ciliary motility (HP:0012262)6.17134106
8Rhinitis (HP:0012384)5.93858507
9Chronic bronchitis (HP:0004469)5.49466459
10Bronchiectasis (HP:0002110)4.63004236
11Dysdiadochokinesis (HP:0002075)4.46813673
12Genetic anticipation (HP:0003743)3.74301674
13Nasal polyposis (HP:0100582)3.70632496
14Bronchitis (HP:0012387)3.44440048
15Pancreatic fibrosis (HP:0100732)3.33337916
16Pancreatic cysts (HP:0001737)3.15829677
17True hermaphroditism (HP:0010459)3.15533028
18Microretrognathia (HP:0000308)3.13032961
19Molar tooth sign on MRI (HP:0002419)3.10174130
20Abnormality of midbrain morphology (HP:0002418)3.10174130
21Absent rod-and cone-mediated responses on ERG (HP:0007688)3.06514417
22Renal cortical cysts (HP:0000803)3.02273205
23Abnormality of the nasal mucosa (HP:0000433)3.02174274
24Horizontal nystagmus (HP:0000666)2.98590891
25Abnormality of the renal cortex (HP:0011035)2.94281620
26Shawl scrotum (HP:0000049)2.87621365
27Retrobulbar optic neuritis (HP:0100654)2.78974900
28Optic neuritis (HP:0100653)2.78974900
29Recurrent sinusitis (HP:0011108)2.69431827
30Recurrent otitis media (HP:0000403)2.67275483
31Abnormal pancreas size (HP:0012094)2.67000168
32Elevated erythrocyte sedimentation rate (HP:0003565)2.56739306
33Infertility (HP:0000789)2.53895569
34Impaired smooth pursuit (HP:0007772)2.46527200
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.41986589
36Cystic liver disease (HP:0006706)2.41655522
37Abnormality of saccadic eye movements (HP:0000570)2.41368992
38Myositis (HP:0100614)2.40772826
39Progressive cerebellar ataxia (HP:0002073)2.37545990
40Hypoproteinemia (HP:0003075)2.36297358
41Nephronophthisis (HP:0000090)2.35748243
42Chronic sinusitis (HP:0011109)2.34958116
43T lymphocytopenia (HP:0005403)2.32961901
44Abnormality of the renal collecting system (HP:0004742)2.31840467
45Congenital stationary night blindness (HP:0007642)2.30728488
46Abnormal rod and cone electroretinograms (HP:0008323)2.30695634
47Duplicated collecting system (HP:0000081)2.29293314
48Abnormality of T cell number (HP:0011839)2.28564882
49Severe combined immunodeficiency (HP:0004430)2.28475237
50Orchitis (HP:0100796)2.28336557
51Bile duct proliferation (HP:0001408)2.26744031
52Abnormal biliary tract physiology (HP:0012439)2.26744031
53IgG deficiency (HP:0004315)2.25902826
54Medial flaring of the eyebrow (HP:0010747)2.21733083
55Abnormality of T cells (HP:0002843)2.19195996
56Dysmetric saccades (HP:0000641)2.15775533
57Gait imbalance (HP:0002141)2.13880428
58Autoimmune hemolytic anemia (HP:0001890)2.13645544
59Abnormality of the pons (HP:0007361)2.12801861
60Occipital encephalocele (HP:0002085)2.12785452
61Congenital primary aphakia (HP:0007707)2.08278870
62Abnormality of the renal medulla (HP:0100957)2.08105171
63Aplasia/Hypoplasia of the fovea (HP:0008060)2.07430692
64Hypoplasia of the fovea (HP:0007750)2.07430692
65Recurrent bronchitis (HP:0002837)2.03484391
66Thyroiditis (HP:0100646)2.03040369
67Chronic hepatic failure (HP:0100626)2.02288916
68Esotropia (HP:0000565)2.01471750
69Hypoplasia of the pons (HP:0012110)1.99213667
70Decreased central vision (HP:0007663)1.98124876
71Birth length less than 3rd percentile (HP:0003561)1.95968433
72Abnormality of eosinophils (HP:0001879)1.92421172
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89953201
74Abnormality of alanine metabolism (HP:0010916)1.89953201
75Hyperalaninemia (HP:0003348)1.89953201
76Broad distal phalanx of finger (HP:0009836)1.88890250
77Stomach cancer (HP:0012126)1.88528074
78Action tremor (HP:0002345)1.87660366
79Postaxial foot polydactyly (HP:0001830)1.86517752
80Keratoconjunctivitis sicca (HP:0001097)1.85613433
81Gaze-evoked nystagmus (HP:0000640)1.84304034
82Hyperkalemia (HP:0002153)1.80790932
83Keratoconjunctivitis (HP:0001096)1.79606482
84Decreased circulating renin level (HP:0003351)1.79074616
85Anencephaly (HP:0002323)1.78934863
86Tubular atrophy (HP:0000092)1.77243662
87Combined immunodeficiency (HP:0005387)1.77126973
88Abnormality of T cell physiology (HP:0011840)1.77110827
89Abnormality of ocular smooth pursuit (HP:0000617)1.74219378
90Mesangial abnormality (HP:0001966)1.72688907
91Encephalitis (HP:0002383)1.71998839
92Chronic otitis media (HP:0000389)1.70971134
93Asplenia (HP:0001746)1.68138725
94Nephrogenic diabetes insipidus (HP:0009806)1.68099468
95Pendular nystagmus (HP:0012043)1.67289070
96Azoospermia (HP:0000027)1.67012653
97Clumsiness (HP:0002312)1.66595769
98Oculomotor apraxia (HP:0000657)1.64464375
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.64026372
100Autoimmune thrombocytopenia (HP:0001973)1.63217228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.07560101
2TXK3.89906207
3ACVR1B3.73529164
4KDR3.00458201
5TAOK32.89867274
6WNK42.64954486
7MAPK152.51342421
8ADRBK22.32814970
9MAP2K62.25449041
10FRK2.15468007
11GRK72.07150079
12MAP2K22.02033289
13MAP4K12.01775338
14ZAK1.99806395
15DAPK21.86439115
16GRK11.83977766
17TLK11.78722469
18TRPM71.75379099
19WNK31.71156182
20JAK31.67991944
21MAPK131.64084114
22JAK11.60660442
23ITK1.58853086
24MAP3K141.40418050
25PRKCQ1.31840815
26SYK1.29644654
27TGFBR21.24548415
28EIF2AK21.21044610
29PTK2B1.20402581
30BMPR1B1.17142679
31RIPK41.16250423
32BMX1.15703166
33TBK11.13873547
34PIK3CA1.13576432
35MATK1.12286791
36IKBKE1.10777149
37TESK21.10546110
38PRKCH1.04999746
39TTK1.04836561
40KIT1.00440621
41EPHA31.00047182
42CSF1R0.98890338
43ZAP700.97353521
44ADRBK10.97133114
45TEC0.94045862
46TYK20.93607672
47GRK60.91037793
48PIK3CG0.89616165
49WNK10.89106096
50PINK10.87476288
51IKBKB0.85835334
52STK100.85378947
53LYN0.84438312
54LCK0.77918459
55DYRK30.73758996
56TIE10.73340396
57MAP2K10.72574460
58TGFBR10.68875621
59CSK0.67572969
60TNK20.67164848
61INSRR0.66538398
62JAK20.66236474
63NEK90.64396048
64TNIK0.64257853
65BLK0.63372108
66PRKCE0.62526168
67ERBB20.61903981
68BCKDK0.56318114
69IGF1R0.55169560
70CAMK2A0.51568814
71FES0.51330222
72PIM10.50722840
73SGK10.49269900
74PRKCA0.49003588
75PDK10.48869340
76CLK10.48788166
77MARK30.46190208
78MAPK70.45946923
79BTK0.45700215
80MAP2K30.45161301
81PRKCG0.44154845
82CASK0.44135984
83PRKCI0.42488656
84DYRK20.42185060
85MAP3K50.40871273
86MAP3K110.40595356
87MYLK0.37928718
88EPHB10.33733415
89TRIM280.33680246
90MAPK120.33665603
91HIPK20.32470969
92NEK20.31763462
93MST1R0.31361912
94MAPK30.31012009
95FYN0.30901298
96MAPKAPK30.30379506
97CAMK2G0.30176801
98CHUK0.29350728
99CAMKK10.29075456
100BMPR20.28628833

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.64905515
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.96667091
3Antigen processing and presentation_Homo sapiens_hsa046122.85455956
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.85051936
5Graft-versus-host disease_Homo sapiens_hsa053322.82203967
6Nicotine addiction_Homo sapiens_hsa050332.30830367
7Linoleic acid metabolism_Homo sapiens_hsa005912.21768356
8Taste transduction_Homo sapiens_hsa047422.12926185
9ABC transporters_Homo sapiens_hsa020102.03346143
10Autoimmune thyroid disease_Homo sapiens_hsa053201.97055287
11Allograft rejection_Homo sapiens_hsa053301.96832491
12Caffeine metabolism_Homo sapiens_hsa002321.88393812
13Hematopoietic cell lineage_Homo sapiens_hsa046401.81887640
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79543413
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.78185361
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76335575
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.74673213
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72335202
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.71651136
20Chemical carcinogenesis_Homo sapiens_hsa052041.64818290
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58276034
22Propanoate metabolism_Homo sapiens_hsa006401.54417500
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51592369
24Type I diabetes mellitus_Homo sapiens_hsa049401.46589305
25Rheumatoid arthritis_Homo sapiens_hsa053231.46085492
26Retinol metabolism_Homo sapiens_hsa008301.43369170
27Histidine metabolism_Homo sapiens_hsa003401.41019551
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35724797
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35035201
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33744405
31Asthma_Homo sapiens_hsa053101.32836602
32Phototransduction_Homo sapiens_hsa047441.31941312
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31275721
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27929799
35beta-Alanine metabolism_Homo sapiens_hsa004101.24487547
36Tryptophan metabolism_Homo sapiens_hsa003801.21326711
37T cell receptor signaling pathway_Homo sapiens_hsa046601.15453302
38Butanoate metabolism_Homo sapiens_hsa006501.15448636
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15219562
40Huntingtons disease_Homo sapiens_hsa050161.14874685
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13235564
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.13114044
43Olfactory transduction_Homo sapiens_hsa047401.12690737
44Proteasome_Homo sapiens_hsa030501.05225379
45Calcium signaling pathway_Homo sapiens_hsa040201.02063410
46Morphine addiction_Homo sapiens_hsa050321.01240751
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.00726305
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99692045
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.98974270
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97579296
51Nitrogen metabolism_Homo sapiens_hsa009100.97367025
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92796303
53Sulfur relay system_Homo sapiens_hsa041220.90067064
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88389502
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.88268836
56Homologous recombination_Homo sapiens_hsa034400.88198797
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88021269
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.87872162
59RNA polymerase_Homo sapiens_hsa030200.84845067
60Oxidative phosphorylation_Homo sapiens_hsa001900.84382528
61Phenylalanine metabolism_Homo sapiens_hsa003600.82569658
62Peroxisome_Homo sapiens_hsa041460.80497948
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79430732
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76629140
65GABAergic synapse_Homo sapiens_hsa047270.75710594
66Measles_Homo sapiens_hsa051620.75671987
67Arachidonic acid metabolism_Homo sapiens_hsa005900.75636188
68Tyrosine metabolism_Homo sapiens_hsa003500.74581462
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74144805
70Malaria_Homo sapiens_hsa051440.72562418
71Glutamatergic synapse_Homo sapiens_hsa047240.70394684
72Serotonergic synapse_Homo sapiens_hsa047260.69075817
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.67077620
74TNF signaling pathway_Homo sapiens_hsa046680.65520104
75Ether lipid metabolism_Homo sapiens_hsa005650.61950817
76Legionellosis_Homo sapiens_hsa051340.60383529
77Fanconi anemia pathway_Homo sapiens_hsa034600.59588788
78Long-term depression_Homo sapiens_hsa047300.58441527
79Chemokine signaling pathway_Homo sapiens_hsa040620.57497582
80Fat digestion and absorption_Homo sapiens_hsa049750.53423665
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52815805
82Parkinsons disease_Homo sapiens_hsa050120.52755036
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.50137697
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47991633
85Salmonella infection_Homo sapiens_hsa051320.47668332
86Glycerolipid metabolism_Homo sapiens_hsa005610.45377426
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44539249
88Regulation of autophagy_Homo sapiens_hsa041400.44368255
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43163525
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.34237263
91Mineral absorption_Homo sapiens_hsa049780.32503603
92Apoptosis_Homo sapiens_hsa042100.31649771
93Alzheimers disease_Homo sapiens_hsa050100.31432503
94Collecting duct acid secretion_Homo sapiens_hsa049660.29328454
95Staphylococcus aureus infection_Homo sapiens_hsa051500.27750241
96Leishmaniasis_Homo sapiens_hsa051400.27692235
97Protein export_Homo sapiens_hsa030600.25962786
98Metabolic pathways_Homo sapiens_hsa011000.25100288
99Herpes simplex infection_Homo sapiens_hsa051680.23442063
100Renin secretion_Homo sapiens_hsa049240.23102947

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