CD207

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.77939764
2keratinization (GO:0031424)9.60445089
3vitamin D metabolic process (GO:0042359)7.69911517
4multicellular organismal water homeostasis (GO:0050891)6.90267174
5vitamin biosynthetic process (GO:0009110)6.83871284
6keratinocyte proliferation (GO:0043616)6.70992780
7keratinocyte differentiation (GO:0030216)6.07522697
8water homeostasis (GO:0030104)5.86870416
9peptide cross-linking (GO:0018149)5.83887465
10surfactant homeostasis (GO:0043129)5.71368841
11molting cycle (GO:0042303)5.59247256
12hair cycle (GO:0042633)5.59247256
13positive regulation of chemokine secretion (GO:0090197)5.50245027
14thrombin receptor signaling pathway (GO:0070493)5.42096338
15epithelial cell differentiation involved in prostate gland development (GO:0060742)5.35583734
16positive regulation of antigen processing and presentation (GO:0002579)5.34705444
17G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.05391259
18detection of bacterium (GO:0016045)5.02314604
19epidermal cell differentiation (GO:0009913)4.93288950
20intermediate filament organization (GO:0045109)4.92321416
21L-phenylalanine catabolic process (GO:0006559)4.89134871
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.89134871
23regulation of chemokine secretion (GO:0090196)4.88941194
24lipoxygenase pathway (GO:0019372)4.81889026
25bile acid biosynthetic process (GO:0006699)4.65955246
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.51240076
27L-phenylalanine metabolic process (GO:0006558)4.51240076
28chemical homeostasis within a tissue (GO:0048875)4.49994720
29aromatic amino acid family catabolic process (GO:0009074)4.46831222
30bundle of His cell to Purkinje myocyte communication (GO:0086069)4.41763252
31detection of other organism (GO:0098543)4.38039082
32alpha-linolenic acid metabolic process (GO:0036109)4.37789034
33polyol biosynthetic process (GO:0046173)4.37418561
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.37001160
35regulation of antigen processing and presentation (GO:0002577)4.32992256
36epidermis development (GO:0008544)4.29098476
37biotin metabolic process (GO:0006768)4.05651608
38regulation of protein activation cascade (GO:2000257)4.03796744
39tryptophan catabolic process (GO:0006569)4.01701221
40indole-containing compound catabolic process (GO:0042436)4.01701221
41indolalkylamine catabolic process (GO:0046218)4.01701221
42long-chain fatty acid biosynthetic process (GO:0042759)3.94855139
43regulation of triglyceride catabolic process (GO:0010896)3.83887797
44regulation of complement activation (GO:0030449)3.81931492
45urea metabolic process (GO:0019627)3.81777438
46urea cycle (GO:0000050)3.81777438
47complement activation, alternative pathway (GO:0006957)3.81262823
48bile acid metabolic process (GO:0008206)3.80989251
49regulation of cholesterol biosynthetic process (GO:0045540)3.79889475
50G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.76065352
51negative regulation of protein activation cascade (GO:2000258)3.74480924
52amino-acid betaine metabolic process (GO:0006577)3.72474630
53regulation of fibrinolysis (GO:0051917)3.72289759
54high-density lipoprotein particle remodeling (GO:0034375)3.71238970
55tryptophan metabolic process (GO:0006568)3.69675825
56purinergic nucleotide receptor signaling pathway (GO:0035590)3.67989011
57negative regulation of fibrinolysis (GO:0051918)3.67954476
58kynurenine metabolic process (GO:0070189)3.64713107
59nitrogen cycle metabolic process (GO:0071941)3.63257243
60desmosome organization (GO:0002934)3.62083504
61phospholipid efflux (GO:0033700)3.59685113
62peptidyl-glutamic acid carboxylation (GO:0017187)3.57617298
63protein carboxylation (GO:0018214)3.57617298
64detection of external biotic stimulus (GO:0098581)3.56274486
65fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.54937250
66hair follicle morphogenesis (GO:0031069)3.51202081
67glyoxylate metabolic process (GO:0046487)3.47239051
68negative regulation of lipase activity (GO:0060192)3.46797116
69positive regulation of keratinocyte differentiation (GO:0045618)3.46023658
70regulation of cholesterol esterification (GO:0010872)3.41431946
71regulation of dendritic cell antigen processing and presentation (GO:0002604)3.40148561
72regulation of keratinocyte differentiation (GO:0045616)3.39459124
73negative regulation of complement activation (GO:0045916)3.36743418
74hemidesmosome assembly (GO:0031581)3.35894694
75fatty acid elongation (GO:0030497)3.35754800
76carnitine metabolic process (GO:0009437)3.34276138
77regulation of cholesterol metabolic process (GO:0090181)3.33966725
78regulation of hypersensitivity (GO:0002883)3.30086844
79skin morphogenesis (GO:0043589)3.27081929
80plasma lipoprotein particle clearance (GO:0034381)3.27060008
81homocysteine metabolic process (GO:0050667)3.26747897
82fibrinolysis (GO:0042730)3.26729145
83cellular biogenic amine catabolic process (GO:0042402)3.22700238
84amine catabolic process (GO:0009310)3.22700238
85serine family amino acid catabolic process (GO:0009071)3.21844153
86sulfur amino acid catabolic process (GO:0000098)3.20601137
87fat-soluble vitamin metabolic process (GO:0006775)3.20465195
88primary alcohol catabolic process (GO:0034310)3.19953260
89protein kinase C signaling (GO:0070528)3.18013787
90purinergic receptor signaling pathway (GO:0035587)3.17285597
91acylglycerol homeostasis (GO:0055090)3.16614303
92triglyceride homeostasis (GO:0070328)3.16614303
93plasma lipoprotein particle remodeling (GO:0034369)3.15671532
94protein-lipid complex remodeling (GO:0034368)3.15671532
95macromolecular complex remodeling (GO:0034367)3.15671532
96phosphatidylinositol acyl-chain remodeling (GO:0036149)3.13878662
97phosphatidylserine acyl-chain remodeling (GO:0036150)3.13434147
98interferon-gamma-mediated signaling pathway (GO:0060333)3.11216596
99regulation of phospholipase A2 activity (GO:0032429)3.10892416
100reverse cholesterol transport (GO:0043691)3.09244862
101detection of biotic stimulus (GO:0009595)3.08983648
102alpha-amino acid catabolic process (GO:1901606)3.08344305
103negative regulation of homotypic cell-cell adhesion (GO:0034111)3.07754027
104cyclooxygenase pathway (GO:0019371)3.07668144
105adhesion of symbiont to host cell (GO:0044650)3.04788002
106virion attachment to host cell (GO:0019062)3.04788002
107negative regulation of cholesterol transport (GO:0032375)3.02569191
108negative regulation of sterol transport (GO:0032372)3.02569191
109glutamate metabolic process (GO:0006536)3.01337251
110very long-chain fatty acid metabolic process (GO:0000038)3.01309416
111intermediate filament cytoskeleton organization (GO:0045104)3.00608126
112imidazole-containing compound metabolic process (GO:0052803)3.00520304
113positive regulation of lipid catabolic process (GO:0050996)2.99717347
114cysteine metabolic process (GO:0006534)2.98865326
115aromatic amino acid family metabolic process (GO:0009072)2.98568234
116short-chain fatty acid metabolic process (GO:0046459)2.97064091
117regulation of natural killer cell differentiation (GO:0032823)2.93484859
118establishment of tissue polarity (GO:0007164)2.93192986
119establishment of planar polarity (GO:0001736)2.93192986
120antigen processing and presentation of endogenous antigen (GO:0019883)2.92515533
121ethanol oxidation (GO:0006069)2.91803255
122tyrosine metabolic process (GO:0006570)2.91603116
123cholesterol homeostasis (GO:0042632)2.90860979
124positive regulation of epidermal cell differentiation (GO:0045606)2.88781638
125T-helper 1 type immune response (GO:0042088)2.88756713
126peptide catabolic process (GO:0043171)2.88517715
127positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.88308316
128linoleic acid metabolic process (GO:0043651)2.86947504
129intermediate filament-based process (GO:0045103)2.86619769
130histone H3-K36 demethylation (GO:0070544)2.85827374
131positive regulation of granulocyte chemotaxis (GO:0071624)2.84493311
132positive regulation of T cell cytokine production (GO:0002726)2.84173378
133retinol metabolic process (GO:0042572)2.83497886
134sterol homeostasis (GO:0055092)2.82983565
135ethanol metabolic process (GO:0006067)2.82669009
136one-carbon compound transport (GO:0019755)2.80244642
137bile acid and bile salt transport (GO:0015721)2.79947333
138complement activation (GO:0006956)2.79089955
139protein activation cascade (GO:0072376)2.78312023
140regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78166854
141cholesterol efflux (GO:0033344)2.77823039
142cellular amino acid catabolic process (GO:0009063)2.77742378
143production of molecular mediator involved in inflammatory response (GO:0002532)2.76421918
144complement activation, classical pathway (GO:0006958)2.75901780
145iron ion import (GO:0097286)2.75147903
146cellular ketone body metabolic process (GO:0046950)2.74264625
147arginine metabolic process (GO:0006525)2.71952665
148negative regulation of blood coagulation (GO:0030195)2.70831416
149negative regulation of hemostasis (GO:1900047)2.70831416
150lateral sprouting from an epithelium (GO:0060601)2.70440018
151immunoglobulin mediated immune response (GO:0016064)2.69643122
152adhesion of symbiont to host (GO:0044406)2.63607136
153long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.59334711
154polyol transport (GO:0015791)2.58527786
155polarized epithelial cell differentiation (GO:0030859)2.53517841
156negative thymic T cell selection (GO:0045060)2.53326873
157long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.53030040
158negative regulation of humoral immune response (GO:0002921)2.51589339
159modulation by symbiont of host defense response (GO:0052031)2.50657040
160modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.50657040
161modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.50657040
162positive regulation by organism of defense response of other organism involved in symbiotic interact2.50657040
163modulation by symbiont of host immune response (GO:0052553)2.50657040
164positive regulation by symbiont of host defense response (GO:0052509)2.50657040
165phosphatidylcholine acyl-chain remodeling (GO:0036151)2.48084214
166primary alcohol metabolic process (GO:0034308)2.47692507
167phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.46207598
168macrophage activation involved in immune response (GO:0002281)2.46195093
169gap junction assembly (GO:0016264)2.43433559
170negative regulation of interferon-gamma production (GO:0032689)2.43278547
171molting cycle process (GO:0022404)2.40966722
172hair cycle process (GO:0022405)2.40966722
173regulation of chemokine-mediated signaling pathway (GO:0070099)2.39716569
174phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.39271810
175positive regulation of cellular amide metabolic process (GO:0034250)2.39010369
176NIK/NF-kappaB signaling (GO:0038061)2.36484805
177positive regulation of type 2 immune response (GO:0002830)2.35603405
178glycosphingolipid catabolic process (GO:0046479)2.33192175
179regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.31071523
180unsaturated fatty acid biosynthetic process (GO:0006636)2.30135505
181positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.29208728
182endothelium development (GO:0003158)2.28663324
183positive regulation of epidermis development (GO:0045684)2.27756463
184positive regulation of neutrophil migration (GO:1902624)2.27325006
185positive regulation of neutrophil chemotaxis (GO:0090023)2.27325006
186fat-soluble vitamin biosynthetic process (GO:0042362)16.5890972
187establishment of skin barrier (GO:0061436)11.2547511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.12700763
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.23203299
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse6.10052365
4GATA1_22025678_ChIP-Seq_K562_Human4.15787812
5RXR_22158963_ChIP-Seq_LIVER_Mouse4.15132546
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.88283165
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.66250573
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.40416065
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.37456925
10LXR_22158963_ChIP-Seq_LIVER_Mouse3.24914846
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.89758515
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.56671984
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.24599453
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.09999110
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02297311
16IRF8_21731497_ChIP-ChIP_J774_Mouse1.96193011
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90363083
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.87329352
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.83446642
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.79993059
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.75916817
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.75452122
23TP63_23658742_ChIP-Seq_EP156T_Human1.72773645
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51619376
25KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44950116
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43474783
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42673517
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41839657
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.40708905
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.39940404
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39373731
32EZH2_22144423_ChIP-Seq_EOC_Human1.39121465
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35697537
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.33865384
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.33729121
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30303867
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29968618
38TP63_22573176_ChIP-Seq_HFKS_Human1.29266545
39BCAT_22108803_ChIP-Seq_LS180_Human1.28131075
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.27328416
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.26999301
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26866225
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26479648
44AHR_22903824_ChIP-Seq_MCF-7_Human1.24839285
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22258557
46GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.20961066
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20277583
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20039563
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.19161145
50VDR_24787735_ChIP-Seq_THP-1_Human1.18439099
51P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16648057
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16004426
53LXR_22292898_ChIP-Seq_THP-1_Human1.15856152
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.14646873
55RUNX_20019798_ChIP-Seq_JUKART_Human1.12680902
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11805793
57GATA6_21074721_ChIP-Seq_CACO-2_Human1.10893497
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10877118
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08516526
60KLF5_25053715_ChIP-Seq_YYC3_Human1.08402196
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06547739
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05776992
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05070208
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04912360
65RACK7_27058665_Chip-Seq_MCF-7_Human1.03866762
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.01889031
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.01857776
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.01857776
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98867781
70AR_21572438_ChIP-Seq_LNCaP_Human0.98826406
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97265874
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96690690
73GATA3_24758297_ChIP-Seq_MCF-7_Human0.96367910
74CLOCK_20551151_ChIP-Seq_293T_Human0.94018752
75GATA6_25053715_ChIP-Seq_YYC3_Human0.93249429
76ARNT_22903824_ChIP-Seq_MCF-7_Human0.92471193
77RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91962392
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91750970
79FOXO3_23340844_ChIP-Seq_DLD1_Human0.91568788
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89950679
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88983071
82EP300_21415370_ChIP-Seq_HL-1_Mouse0.88858848
83KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88616000
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88562083
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88451674
86SOX2_20726797_ChIP-Seq_SW620_Human0.88317137
87HNFA_21074721_ChIP-Seq_CACO-2_Human0.88155081
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87200659
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87101110
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86850611
91GATA2_19941826_ChIP-Seq_K562_Human0.86369390
92BRD4_27068464_Chip-Seq_AML-cells_Mouse0.85708774
93TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85392023
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85148117
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84749464
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84749464
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84427337
98KDM2B_26808549_Chip-Seq_K562_Human0.84331987
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.84036915
100TP53_18474530_ChIP-ChIP_U2OS_Human0.81938107
101MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81886695
102SCL_19346495_ChIP-Seq_HPC-7_Human0.81710451
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81353948
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81242162
105P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.81066511
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80743102
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80582317
108SMC4_20622854_ChIP-Seq_HELA_Human0.80400819
109BCOR_27268052_Chip-Seq_Bcells_Human0.80069460
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.79802142
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78019749
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77300930
113SUZ12_27294783_Chip-Seq_ESCs_Mouse0.77223436
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.77002691
115SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.75373373
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74220028
117HTT_18923047_ChIP-ChIP_STHdh_Human0.74174691
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73941780
119CDX2_22108803_ChIP-Seq_LS180_Human0.73353720
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.72419290
121CJUN_26792858_Chip-Seq_BT549_Human0.72151126
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72064411
123GATA1_19941826_ChIP-Seq_K562_Human0.71861820
124SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.71175310
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71028605
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.70831178
127CBP_21632823_ChIP-Seq_H3396_Human0.70822275
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.70711235
129EZH2_27294783_Chip-Seq_ESCs_Mouse0.70353915
130RNF2_18974828_ChIP-Seq_MESCs_Mouse0.70049116
131EZH2_18974828_ChIP-Seq_MESCs_Mouse0.70049116
132EED_16625203_ChIP-ChIP_MESCs_Mouse0.69997566
133EGR1_19032775_ChIP-ChIP_M12_Human0.69504663
134RXR_22108803_ChIP-Seq_LS180_Human0.69234027
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68633865
136JARID2_20064375_ChIP-Seq_MESCs_Mouse0.67936263
137FOXA2_19822575_ChIP-Seq_HepG2_Human0.66744580
138JARID2_20075857_ChIP-Seq_MESCs_Mouse0.65790369
139STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.64448860
140SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.64369641
141GATA4_25053715_ChIP-Seq_YYC3_Human0.63843827
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.63212309
143SRY_22984422_ChIP-ChIP_TESTIS_Rat0.61966203
144NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61950987
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61950987
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.61442341
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.61242857
148EZH2_27304074_Chip-Seq_ESCs_Mouse0.61135153
149PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60335467
150NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.60271071
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.60127509
152LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.59857275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.23085407
2MP0002139_abnormal_hepatobiliary_system5.16564006
3MP0005085_abnormal_gallbladder_physiolo4.65969415
4MP0009379_abnormal_foot_pigmentation4.29450280
5MP0004381_abnormal_hair_follicle4.16515801
6MP0002796_impaired_skin_barrier4.09437998
7MP0005365_abnormal_bile_salt4.08079304
8MP0008875_abnormal_xenobiotic_pharmacok3.96956249
9MP0010234_abnormal_vibrissa_follicle3.56679751
10MP0005451_abnormal_body_composition3.25368373
11MP0001188_hyperpigmentation2.74690535
12MP0010329_abnormal_lipoprotein_level2.54425279
13MP0005083_abnormal_biliary_tract2.48297754
14MP0003252_abnormal_bile_duct2.44353809
15MP0002095_abnormal_skin_pigmentation2.26387970
16MP0005275_abnormal_skin_tensile2.22305623
17MP0000427_abnormal_hair_cycle2.19702311
18MP0001853_heart_inflammation2.15414998
19MP0002060_abnormal_skin_morphology2.14596649
20MP0000015_abnormal_ear_pigmentation2.03140189
21MP0001243_abnormal_dermal_layer2.02926183
22MP0005409_darkened_coat_color1.99230167
23MP0003879_abnormal_hair_cell1.98273258
24MP0005501_abnormal_skin_physiology1.89680686
25MP0003806_abnormal_nucleotide_metabolis1.89517568
26MP0004947_skin_inflammation1.86533829
27MP0000647_abnormal_sebaceous_gland1.81044467
28MP0009840_abnormal_foam_cell1.79983401
29MP0005332_abnormal_amino_acid1.77493131
30MP0002254_reproductive_system_inflammat1.74877029
31MP0003195_calcinosis1.73911446
32MP0005075_abnormal_melanosome_morpholog1.72430260
33MP0003436_decreased_susceptibility_to1.71973442
34MP0005174_abnormal_tail_pigmentation1.70381888
35MP0000566_synostosis1.64880331
36MP0002118_abnormal_lipid_homeostasis1.64875451
37MP0004782_abnormal_surfactant_physiolog1.60101943
38MP0010678_abnormal_skin_adnexa1.58024787
39MP0001666_abnormal_nutrient_absorption1.57592529
40MP0000609_abnormal_liver_physiology1.53862120
41MP0001216_abnormal_epidermal_layer1.53678696
42MP0001835_abnormal_antigen_presentation1.48550259
43MP0000465_gastrointestinal_hemorrhage1.46834596
44MP0002102_abnormal_ear_morphology1.46592885
45MP0003191_abnormal_cellular_cholesterol1.43340513
46MP0009764_decreased_sensitivity_to1.42598639
47MP0010771_integument_phenotype1.40742064
48MP0008004_abnormal_stomach_pH1.35127290
49MP0003878_abnormal_ear_physiology1.35043368
50MP0005377_hearing/vestibular/ear_phenot1.35043368
51MP0000685_abnormal_immune_system1.34516887
52MP0003941_abnormal_skin_development1.34316594
53MP0003566_abnormal_cell_adhesion1.25642252
54MP0004142_abnormal_muscle_tone1.21533523
55MP0005670_abnormal_white_adipose1.19403689
56MP0004019_abnormal_vitamin_homeostasis1.19115843
57MP0003724_increased_susceptibility_to1.17830624
58MP0000377_abnormal_hair_follicle1.09019535
59MP0003303_peritoneal_inflammation1.08886446
60MP0005503_abnormal_tendon_morphology1.08582881
61MP0003453_abnormal_keratinocyte_physiol1.08493479
62MP0002138_abnormal_hepatobiliary_system1.07265177
63MP0010352_gastrointestinal_tract_polyps1.05249746
64MP0004185_abnormal_adipocyte_glucose1.03256806
65MP0000579_abnormal_nail_morphology1.01541551
66MP0001851_eye_inflammation1.00520053
67MP0005464_abnormal_platelet_physiology0.97637883
68MP0004742_abnormal_vestibular_system0.97388690
69MP0005319_abnormal_enzyme/_coenzyme0.97037798
70MP0005058_abnormal_lysosome_morphology0.96594321
71MP0001958_emphysema0.94369498
72MP0000383_abnormal_hair_follicle0.92368279
73MP0008438_abnormal_cutaneous_collagen0.91469470
74MP0005647_abnormal_sex_gland0.91031683
75MP0004510_myositis0.89835293
76MP0000367_abnormal_coat/_hair0.88573290
77MP0009643_abnormal_urine_homeostasis0.88142407
78MP0000467_abnormal_esophagus_morphology0.87686470
79MP0005671_abnormal_response_to0.86824092
80MP0005023_abnormal_wound_healing0.84959600
81MP0009931_abnormal_skin_appearance0.82839802
82MP0004264_abnormal_extraembryonic_tissu0.82411184
83MP0000604_amyloidosis0.81315334
84MP0002998_abnormal_bone_remodeling0.81200111
85MP0003448_altered_tumor_morphology0.80737598
86MP0001346_abnormal_lacrimal_gland0.80333507
87MP0005387_immune_system_phenotype0.80223883
88MP0001790_abnormal_immune_system0.80223883
89MP0002877_abnormal_melanocyte_morpholog0.79172033
90MP0005584_abnormal_enzyme/coenzyme_acti0.77714668
91MP0001800_abnormal_humoral_immune0.76519991
92MP0005666_abnormal_adipose_tissue0.73688852
93MP0001845_abnormal_inflammatory_respons0.73654322
94MP0002452_abnormal_antigen_presenting0.72924099
95MP0008469_abnormal_protein_level0.72748771
96MP0009333_abnormal_splenocyte_physiolog0.72018297
97MP0004130_abnormal_muscle_cell0.71957747
98MP0003828_pulmonary_edema0.71867172
99MP0002419_abnormal_innate_immunity0.71006378
100MP0009763_increased_sensitivity_to0.70959803
101MP0003705_abnormal_hypodermis_morpholog0.70454856
102MP0003763_abnormal_thymus_physiology0.70175914
103MP0005334_abnormal_fat_pad0.69744435
104MP0008874_decreased_physiological_sensi0.69145388
105* MP0002148_abnormal_hypersensitivity_rea0.68967371
106MP0003279_aneurysm0.68355987
107MP0001533_abnormal_skeleton_physiology0.68151526
108MP0002166_altered_tumor_susceptibility0.68026491
109MP0003045_fibrosis0.67276966
110MP0001191_abnormal_skin_condition0.66216196
111MP0002133_abnormal_respiratory_system0.65871974
112MP0005388_respiratory_system_phenotype0.65871974
113* MP0005025_abnormal_response_to0.65706664
114MP0001542_abnormal_bone_strength0.65430705
115MP0002098_abnormal_vibrissa_morphology0.65342076
116MP0005000_abnormal_immune_tolerance0.65278918
117MP0009765_abnormal_xenobiotic_induced0.64415980
118MP0003300_gastrointestinal_ulcer0.64334720
119MP0003638_abnormal_response/metabolism_0.62874125
120MP0005165_increased_susceptibility_to0.62824335
121MP0001348_abnormal_lacrimal_gland0.62222191
122MP0002009_preneoplasia0.60729530
123MP0000627_abnormal_mammary_gland0.59810871
124MP0009642_abnormal_blood_homeostasis0.59483798
125MP0003075_altered_response_to0.58774451
126MP0003011_delayed_dark_adaptation0.58632037
127MP0002837_dystrophic_cardiac_calcinosis0.58609523
128MP0000598_abnormal_liver_morphology0.58327954
129MP0003690_abnormal_glial_cell0.57965996
130MP0003868_abnormal_feces_composition0.56630960
131MP0006082_CNS_inflammation0.56289541
132MP0009785_altered_susceptibility_to0.54926912
133MP0002971_abnormal_brown_adipose0.54086693
134MP0005390_skeleton_phenotype0.53889120
135MP0001784_abnormal_fluid_regulation0.53543847
136MP0000858_altered_metastatic_potential0.53366250
137MP0000762_abnormal_tongue_morphology0.52937959
138MP0003718_maternal_effect0.52830333
139MP0001819_abnormal_immune_cell0.52481362
140MP0003091_abnormal_cell_migration0.52460040
141MP0002405_respiratory_system_inflammati0.52448910
142MP0010155_abnormal_intestine_physiology0.52289810
143MP0002277_abnormal_respiratory_mucosa0.51977865
144MP0002723_abnormal_immune_serum0.51685520
145MP0003183_abnormal_peptide_metabolism0.51190281
146MP0002420_abnormal_adaptive_immunity0.50135539
147MP0005248_abnormal_Harderian_gland0.47404788

Predicted human phenotypes

RankGene SetZ-score
1Thin bony cortex (HP:0002753)9.47803205
2Widely patent fontanelles and sutures (HP:0004492)8.19060054
3Enlarged epiphyses (HP:0010580)7.39795766
4Delayed epiphyseal ossification (HP:0002663)7.29078320
5Erythroderma (HP:0001019)6.32036829
6Abnormality of the costochondral junction (HP:0000919)6.15767725
7Conjunctival hamartoma (HP:0100780)5.98983874
8Erythema (HP:0010783)5.70561599
9Alopecia of scalp (HP:0002293)5.36135615
10Flat occiput (HP:0005469)5.29806110
11Abnormality of the axillary hair (HP:0100134)5.27951695
12Abnormality of secondary sexual hair (HP:0009888)5.27951695
13Wide cranial sutures (HP:0010537)5.16561093
14Thick nail (HP:0001805)5.04113974
15Congenital ichthyosiform erythroderma (HP:0007431)4.76928141
16Intrahepatic cholestasis (HP:0001406)4.58109268
17Rickets (HP:0002748)4.48730850
18Abnormality of nail color (HP:0100643)4.45558443
19Deep venous thrombosis (HP:0002625)4.43075364
20Xanthomatosis (HP:0000991)4.42295457
21Abnormality of aromatic amino acid family metabolism (HP:0004338)4.40720748
22Tibial bowing (HP:0002982)4.08753675
23Epidermoid cyst (HP:0200040)4.05539971
24Metaphyseal irregularity (HP:0003025)4.01111301
25Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90168965
26Hamartoma of the eye (HP:0010568)3.89930828
27Prolonged partial thromboplastin time (HP:0003645)3.85070430
28Hyperammonemia (HP:0001987)3.71563719
29Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.66545715
30Pili torti (HP:0003777)3.59579922
31Complement deficiency (HP:0004431)3.52222804
32Hyperlipoproteinemia (HP:0010980)3.46651013
33Abnormality of complement system (HP:0005339)3.34893544
34Progressive hearing impairment (HP:0001730)3.34784598
35Abnormal blistering of the skin (HP:0008066)3.34573348
36Abnormal hair laboratory examination (HP:0003328)3.33413517
37Parakeratosis (HP:0001036)3.28364713
38Gangrene (HP:0100758)3.22116631
39Femoral bowing (HP:0002980)3.21886952
40Hypophosphatemia (HP:0002148)3.16392381
41Corneal erosion (HP:0200020)3.14821210
42Hypobetalipoproteinemia (HP:0003563)3.06531084
43Fragile nails (HP:0001808)3.01617454
44Palmoplantar keratoderma (HP:0000982)2.99260566
45Bone pain (HP:0002653)2.92139104
46Elevated alkaline phosphatase (HP:0003155)2.90772822
47Hypergammaglobulinemia (HP:0010702)2.89182366
48Hyperglycinemia (HP:0002154)2.81466402
49Abnormal enzyme/coenzyme activity (HP:0012379)2.77197973
50Hypoalphalipoproteinemia (HP:0003233)2.73833218
51Joint hemorrhage (HP:0005261)2.72369220
52Xerostomia (HP:0000217)2.72094943
53Sparse scalp hair (HP:0002209)2.69128929
54Abnormal trabecular bone morphology (HP:0100671)2.64595005
55Abnormality of alkaline phosphatase activity (HP:0004379)2.64302276
56Hypolipoproteinemia (HP:0010981)2.63300648
57Abnormal epiphyseal ossification (HP:0010656)2.61446317
58Myocardial infarction (HP:0001658)2.59740615
59Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.57774878
60Ridged nail (HP:0001807)2.56672527
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56300448
62Abnormality of the salivary glands (HP:0010286)2.55077920
63Difficulty walking (HP:0002355)2.51956138
64Sparse eyelashes (HP:0000653)2.50519092
65Abnormality of glycine metabolism (HP:0010895)2.46384039
66Abnormality of serine family amino acid metabolism (HP:0010894)2.46384039
67Abnormality of glycolipid metabolism (HP:0010969)2.44872288
68Abnormality of liposaccharide metabolism (HP:0010968)2.44872288
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.44872288
70Right ventricular cardiomyopathy (HP:0011663)2.43685890
71Hypotrichosis (HP:0001006)2.39701417
72Abnormality of the common coagulation pathway (HP:0010990)2.38291208
73Ketosis (HP:0001946)2.38152854
74Absent eyelashes (HP:0000561)2.37085256
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.33714633
76Osteolytic defects of the hand bones (HP:0009699)2.33714633
77Abnormal cortical bone morphology (HP:0003103)2.32549101
78Melanocytic nevus (HP:0000995)2.31921058
79Submucous cleft hard palate (HP:0000176)2.29699936
80Lip pit (HP:0100267)2.29656240
81Amyloidosis (HP:0011034)2.26401008
82Nail dystrophy (HP:0008404)2.26289872
83Systemic lupus erythematosus (HP:0002725)2.23745604
84Distal lower limb muscle weakness (HP:0009053)2.22829324
85Milia (HP:0001056)2.21631994
86Fat malabsorption (HP:0002630)2.20871189
87Periodontitis (HP:0000704)2.18311920
88Increased IgE level (HP:0003212)2.16647955
89Hypohidrosis (HP:0000966)2.15870767
90Blepharitis (HP:0000498)2.15658219
91Recurrent gram-negative bacterial infections (HP:0005420)2.15465410
92Urticaria (HP:0001025)2.14247735
93Cerebral palsy (HP:0100021)2.14109551
94Abnormality of the dental root (HP:0006486)2.13922390
95Taurodontia (HP:0000679)2.13922390
96Abnormality of permanent molar morphology (HP:0011071)2.13922390
97Pruritus (HP:0000989)2.13685101
98Slow-growing hair (HP:0002217)2.11531193
99Abnormality of hair growth rate (HP:0011363)2.11531193
100Recurrent skin infections (HP:0001581)2.10307843
101Hypercholesterolemia (HP:0003124)2.09581021
102Nephritis (HP:0000123)2.09281510
103Abnormality of the dental pulp (HP:0006479)2.09077350
104Hamartoma (HP:0010566)2.08086854
105Hypoplastic labia majora (HP:0000059)2.06522436
106Mediastinal lymphadenopathy (HP:0100721)2.04317742
107Conjugated hyperbilirubinemia (HP:0002908)2.04004080
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.01761730
109Abnormality of molar (HP:0011077)2.00989844
110Abnormality of molar morphology (HP:0011070)2.00989844
111Skin ulcer (HP:0200042)2.00798228
112Abnormality of placental membranes (HP:0011409)2.00573193
113Amniotic constriction ring (HP:0009775)2.00573193
114Hyperglycinuria (HP:0003108)2.00455707
115Glomerulonephritis (HP:0000099)1.97247236
116Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96882751
117Abnormality of methionine metabolism (HP:0010901)1.96215755
118Abnormality of small intestinal villus morphology (HP:0011472)1.95676585
119Villous atrophy (HP:0011473)1.95676585
120Spontaneous hematomas (HP:0007420)1.95013493
121Palmoplantar hyperkeratosis (HP:0000972)1.94632764
122Thoracic kyphosis (HP:0002942)1.94015295
123Advanced eruption of teeth (HP:0006288)1.92453220
124Natal tooth (HP:0000695)1.89820819
125Abnormality of sulfur amino acid metabolism (HP:0004339)1.89638104
126Mucopolysacchariduria (HP:0008155)1.88194945
127Urinary glycosaminoglycan excretion (HP:0003541)1.88194945
128Ankyloglossia (HP:0010296)1.86898188
129Skin nodule (HP:0200036)1.86789281
130Malignant hyperthermia (HP:0002047)1.85111706
131Coarse hair (HP:0002208)1.84577823
132Abnormality of the labia majora (HP:0012881)1.84507171
133Abnormality of the lumbar spine (HP:0100712)1.84263543
134Abnormality of serum amino acid levels (HP:0003112)1.83943029
135Abnormality of the gastric mucosa (HP:0004295)1.83284319
136Metaphyseal cupping (HP:0003021)1.82216353
137Hyporeflexia of lower limbs (HP:0002600)1.80153971
138Dry hair (HP:0011359)1.80145900
139Absent hand (HP:0004050)1.78804530
140Hematochezia (HP:0002573)1.78512913
141Selective tooth agenesis (HP:0001592)1.77263501
142Hyperbilirubinemia (HP:0002904)1.76938022
143Colitis (HP:0002583)1.75491372
144Ketoacidosis (HP:0001993)1.74497272
145Palmar hyperkeratosis (HP:0010765)1.74045890
146Abnormality of the Achilles tendon (HP:0005109)1.73989163
147Hyperactive renin-angiotensin system (HP:0000841)1.73670068
148Vacuolated lymphocytes (HP:0001922)1.73602383
149Depressed nasal tip (HP:0000437)1.72344164
150Absent hair (HP:0002298)1.72297095
151Oral leukoplakia (HP:0002745)1.72281111
152Acanthosis nigricans (HP:0000956)1.72233135
153Interstitial pulmonary disease (HP:0006530)1.72075890
154Plantar hyperkeratosis (HP:0007556)1.70909917
155Abnormality of the intrinsic pathway (HP:0010989)1.70769863
156Dysostosis multiplex (HP:0000943)1.70449228
157Aplasia cutis congenita (HP:0001057)1.70106380
158Chronic mucocutaneous candidiasis (HP:0002728)1.69632980
159Recurrent cutaneous fungal infections (HP:0011370)1.69632980
160Abnormality of the fibula (HP:0002991)1.69322226
161Increased cerebral lipofuscin (HP:0011813)1.69171990
162Onycholysis (HP:0001806)1.69056586
163Popliteal pterygium (HP:0009756)1.68952978
164Split foot (HP:0001839)1.68876334
165Abnormality of fatty-acid metabolism (HP:0004359)1.68123630
166Woolly hair (HP:0002224)1.66770640
167Abnormality of polysaccharide metabolism (HP:0011012)1.65842835
168Abnormality of glycosaminoglycan metabolism (HP:0004371)1.65842835
169Abnormality of mucopolysaccharide metabolism (HP:0011020)1.65842835
170Stomatitis (HP:0010280)1.65035658
171Eczematoid dermatitis (HP:0000976)1.64248796
172Coronal craniosynostosis (HP:0004440)1.63959960
173Spontaneous abortion (HP:0005268)1.63826835
174Ectropion (HP:0000656)1.63213098
175Steatorrhea (HP:0002570)1.62665322
176Morphological abnormality of the pyramidal tract (HP:0002062)1.62390226
177Nasolacrimal duct obstruction (HP:0000579)1.62300993
178Recurrent bacterial skin infections (HP:0005406)1.62014019
179Premature loss of primary teeth (HP:0006323)1.60971599
180Aplasia involving bones of the upper limbs (HP:0009823)1.59099380
181Aplasia of the phalanges of the hand (HP:0009802)1.59099380
182Aplasia involving bones of the extremities (HP:0009825)1.59099380
183Hyperhidrosis (HP:0000975)1.57923622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK245.86049242
2MAP3K95.10295829
3MST1R4.94095953
4MAP3K134.75634618
5TGFBR14.05776593
6ARAF3.96925065
7BLK3.43364868
8EEF2K3.20662569
9KSR22.88700040
10RIPK42.76225063
11MAP3K62.73170802
12MAPKAPK32.72271320
13MOS2.37938727
14FGFR32.24063657
15RIPK12.23302149
16PIK3CG2.11388486
17TRIB32.01595397
18EPHA31.99767955
19CDC42BPA1.90262428
20ZAP701.82982908
21PTK61.72716861
22TYK21.50979812
23MET1.44396247
24BCKDK1.41044785
25JAK31.39130892
26PRPF4B1.37430549
27BMPR21.31681873
28CDK31.30876531
29STK31.30569746
30TBK11.30504400
31TRPM71.24840508
32RAF11.18151111
33NEK91.15464015
34BRAF1.15386856
35MAPKAPK51.15146323
36FGFR11.13928289
37FGFR41.13845100
38LATS11.13620617
39EPHA21.11179528
40YES11.09965431
41CDK61.08636480
42EIF2AK21.06576917
43ERN11.06493715
44MAP2K11.05619286
45EPHB11.05245542
46KSR11.04347337
47JAK21.00945041
48CDK120.99763636
49INSRR0.98087034
50MAPK120.94706806
51PDGFRB0.92093286
52TAOK30.91502017
53GRK10.90428668
54SIK10.89919291
55PRKD20.89311844
56MATK0.86621515
57MUSK0.86380372
58TGFBR20.84243369
59PRKAA20.81433327
60MAP3K20.81241825
61LIMK10.80191811
62IRAK10.78898540
63MAP3K140.78883730
64CAMK1D0.76824692
65MAP3K10.76285649
66FGR0.76136518
67CSK0.73880954
68FES0.72331490
69MARK20.71854308
70IKBKE0.70922163
71PRKACG0.69561855
72CAMK10.68639689
73DMPK0.67428809
74MAP2K60.67327896
75RPS6KB20.66449798
76MAP2K40.65390912
77RET0.64780805
78ICK0.63388896
79MAPK40.62008572
80JAK10.61345490
81MAPK70.59521583
82RPS6KB10.57762856
83ERBB40.57720801
84NLK0.57360518
85DAPK20.56332276
86RPS6KA50.55285539
87IGF1R0.55055050
88TTN0.54493871
89TAOK20.53441926
90CSF1R0.52390937
91LRRK20.50868410
92KIT0.49962861
93SYK0.49910931
94MAPK150.49634041
95EPHA40.48931731
96DYRK1B0.48521777
97PDGFRA0.47876963
98SMG10.47509009
99GSK3A0.47186899
100FER0.45968986
101CAMK1G0.45941645
102WNK10.44367323
103MAP3K80.43789541
104PDK10.43720041
105ABL20.43607136
106RPS6KA40.43153296
107PRKCB0.42686514
108ERBB20.42024389
109IKBKB0.41956515
110BTK0.41701368
111CAMK2D0.41080120
112HIPK20.41071451
113SGK30.40969579
114MAP4K10.40863455
115PKN10.40101889
116SGK2230.39364871
117SGK4940.39364871
118FYN0.38550851
119PIM20.37710845
120BRD40.37298585
121NEK60.37191660
122PDPK10.36735730
123MTOR0.36528491
124SGK20.36345046
125PTK20.35122689
126ABL10.34907735
127LYN0.34168735
128CHUK0.34155415
129PRKACA0.32993172
130ITK0.32404428
131RPS6KA20.30881134
132HCK0.29816791
133MAPKAPK20.29747282
134PRKD10.29071936
135DDR20.28895607
136PRKCD0.28493160
137MAP3K30.25927929
138MAP3K70.24933769
139PRKG10.24772611
140CDK50.24653239
141GRK60.24231747
142FGFR20.22224175
143PRKACB0.21643760
144CAMKK10.21623637
145PRKCA0.20390388
146FLT30.20262550
147STK100.19840149
148GRK70.19750180
149MAPK30.19725612
150SGK10.19213437

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.48645877
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.10311348
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.90403481
4Asthma_Homo sapiens_hsa053103.20803937
5Allograft rejection_Homo sapiens_hsa053302.98278323
6Nitrogen metabolism_Homo sapiens_hsa009102.97704242
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.95907668
8Autoimmune thyroid disease_Homo sapiens_hsa053202.80016141
9Graft-versus-host disease_Homo sapiens_hsa053322.70358788
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61953919
11Complement and coagulation cascades_Homo sapiens_hsa046102.61441911
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.51025438
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.47084425
14Arginine biosynthesis_Homo sapiens_hsa002202.42095323
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.41353174
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.32072554
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22723971
18Type I diabetes mellitus_Homo sapiens_hsa049402.16949040
19Fatty acid metabolism_Homo sapiens_hsa012122.09437283
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08687398
21Staphylococcus aureus infection_Homo sapiens_hsa051502.03156464
22Fatty acid degradation_Homo sapiens_hsa000712.02658073
23Fatty acid elongation_Homo sapiens_hsa000622.02160359
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85345139
25Chemical carcinogenesis_Homo sapiens_hsa052041.85282684
26Tryptophan metabolism_Homo sapiens_hsa003801.84249390
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83619550
28Antigen processing and presentation_Homo sapiens_hsa046121.80107561
29Viral myocarditis_Homo sapiens_hsa054161.77093066
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73376113
31Histidine metabolism_Homo sapiens_hsa003401.72320615
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.70700405
33Butanoate metabolism_Homo sapiens_hsa006501.69318814
34Sulfur metabolism_Homo sapiens_hsa009201.65170799
35beta-Alanine metabolism_Homo sapiens_hsa004101.64814437
36Toxoplasmosis_Homo sapiens_hsa051451.63457247
37Tuberculosis_Homo sapiens_hsa051521.59510933
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52154531
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49205684
40Ether lipid metabolism_Homo sapiens_hsa005651.46583541
41PPAR signaling pathway_Homo sapiens_hsa033201.44837033
42Other glycan degradation_Homo sapiens_hsa005111.44539522
43Rheumatoid arthritis_Homo sapiens_hsa053231.41604101
44Hematopoietic cell lineage_Homo sapiens_hsa046401.40650408
45Phenylalanine metabolism_Homo sapiens_hsa003601.39679034
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36582178
47Peroxisome_Homo sapiens_hsa041461.31714919
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.31068957
49Phagosome_Homo sapiens_hsa041451.30615045
50Caffeine metabolism_Homo sapiens_hsa002321.29927070
51Influenza A_Homo sapiens_hsa051641.22199074
52Bile secretion_Homo sapiens_hsa049761.19540878
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14065617
54Tyrosine metabolism_Homo sapiens_hsa003501.09049723
55Retinol metabolism_Homo sapiens_hsa008301.05896467
56Propanoate metabolism_Homo sapiens_hsa006401.05410359
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.03671760
58GnRH signaling pathway_Homo sapiens_hsa049121.03640461
59Drug metabolism - other enzymes_Homo sapiens_hsa009831.01540486
60Glycerolipid metabolism_Homo sapiens_hsa005610.98387254
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97400235
62Starch and sucrose metabolism_Homo sapiens_hsa005000.94421735
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92190320
64One carbon pool by folate_Homo sapiens_hsa006700.87867884
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86001832
66ABC transporters_Homo sapiens_hsa020100.84520130
67Selenocompound metabolism_Homo sapiens_hsa004500.83928215
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.79772057
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77853462
70VEGF signaling pathway_Homo sapiens_hsa043700.77180550
71Herpes simplex infection_Homo sapiens_hsa051680.75672825
72Mineral absorption_Homo sapiens_hsa049780.74417194
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73172245
74Fat digestion and absorption_Homo sapiens_hsa049750.72013707
75Glutathione metabolism_Homo sapiens_hsa004800.71519122
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.68644189
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68134463
78Lysine degradation_Homo sapiens_hsa003100.67619348
79Ovarian steroidogenesis_Homo sapiens_hsa049130.67134917
80Chemokine signaling pathway_Homo sapiens_hsa040620.66598696
81ECM-receptor interaction_Homo sapiens_hsa045120.66560365
82Arachidonic acid metabolism_Homo sapiens_hsa005900.66215184
83Malaria_Homo sapiens_hsa051440.65747815
84Salivary secretion_Homo sapiens_hsa049700.65147298
85Platelet activation_Homo sapiens_hsa046110.64555004
86Prion diseases_Homo sapiens_hsa050200.63595818
87Notch signaling pathway_Homo sapiens_hsa043300.63276795
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63167298
89Folate biosynthesis_Homo sapiens_hsa007900.62762438
90Renin-angiotensin system_Homo sapiens_hsa046140.61918983
91Circadian rhythm_Homo sapiens_hsa047100.61018589
92TNF signaling pathway_Homo sapiens_hsa046680.60662350
93Ras signaling pathway_Homo sapiens_hsa040140.60561818
94Acute myeloid leukemia_Homo sapiens_hsa052210.59130232
95Fatty acid biosynthesis_Homo sapiens_hsa000610.58387418
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57809405
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56470281
98Pancreatic cancer_Homo sapiens_hsa052120.52681283
99Protein digestion and absorption_Homo sapiens_hsa049740.52311039
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51921315
101Renin secretion_Homo sapiens_hsa049240.51901228
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.50761936
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50428848
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.50414932
105Adherens junction_Homo sapiens_hsa045200.49996644
106Arginine and proline metabolism_Homo sapiens_hsa003300.49983849
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48035671
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.47340565
109Estrogen signaling pathway_Homo sapiens_hsa049150.46056346
110Carbon metabolism_Homo sapiens_hsa012000.44888302
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.44265818
112Pyruvate metabolism_Homo sapiens_hsa006200.44126425
113B cell receptor signaling pathway_Homo sapiens_hsa046620.42755774
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.42547705
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42076013
116Biosynthesis of amino acids_Homo sapiens_hsa012300.40964016
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39559448
118Measles_Homo sapiens_hsa051620.38748128
119Renal cell carcinoma_Homo sapiens_hsa052110.36184335
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.35742617
121Systemic lupus erythematosus_Homo sapiens_hsa053220.35058079
122Rap1 signaling pathway_Homo sapiens_hsa040150.34634518
123Hepatitis C_Homo sapiens_hsa051600.34044325
124Proteoglycans in cancer_Homo sapiens_hsa052050.32943337
125Long-term depression_Homo sapiens_hsa047300.32702599
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30612758
127Thyroid cancer_Homo sapiens_hsa052160.30548027
128Linoleic acid metabolism_Homo sapiens_hsa005910.30391261
129Osteoclast differentiation_Homo sapiens_hsa043800.30361319
130Endocytosis_Homo sapiens_hsa041440.29665278
131Dorso-ventral axis formation_Homo sapiens_hsa043200.28493123
132Lysosome_Homo sapiens_hsa041420.27714941
133Focal adhesion_Homo sapiens_hsa045100.27605166
134MicroRNAs in cancer_Homo sapiens_hsa052060.27561520
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26937009
136Vitamin digestion and absorption_Homo sapiens_hsa049770.26426694
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26185966
138Bladder cancer_Homo sapiens_hsa052190.25714584
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.22649270
140Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22047878
141Amoebiasis_Homo sapiens_hsa051460.21489698
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21034677
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20134932
144Metabolic pathways_Homo sapiens_hsa011000.17108275
145Sphingolipid metabolism_Homo sapiens_hsa006000.16055665
146Leishmaniasis_Homo sapiens_hsa051400.15917061
147Pentose phosphate pathway_Homo sapiens_hsa000300.15469748
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.14376397
149Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12817450
150Choline metabolism in cancer_Homo sapiens_hsa052310.12806162
151Insulin resistance_Homo sapiens_hsa049310.11924109
152Toll-like receptor signaling pathway_Homo sapiens_hsa046200.10398773
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.10031829
154Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09509136
155Pertussis_Homo sapiens_hsa051330.09499537
156African trypanosomiasis_Homo sapiens_hsa051430.07944128
157Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.05398609
158AMPK signaling pathway_Homo sapiens_hsa041520.04507187
159Glucagon signaling pathway_Homo sapiens_hsa049220.04415880
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.01805549
161Oxytocin signaling pathway_Homo sapiens_hsa04921-0.0059122
162ErbB signaling pathway_Homo sapiens_hsa04012-0.0046991

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