CD24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)5.78633728
2regulation of posttranscriptional gene silencing (GO:0060147)5.78633728
3regulation of gene silencing by miRNA (GO:0060964)5.78633728
4pre-miRNA processing (GO:0031054)5.31780295
5establishment of integrated proviral latency (GO:0075713)4.77790760
6L-serine metabolic process (GO:0006563)4.38394892
7paraxial mesoderm development (GO:0048339)4.33139792
8regulation of cell fate specification (GO:0042659)3.97092074
9protein complex localization (GO:0031503)3.85934726
10regulation of helicase activity (GO:0051095)3.76901727
11regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.58327389
12establishment of viral latency (GO:0019043)3.55787125
13negative regulation of translation, ncRNA-mediated (GO:0040033)3.48599497
14regulation of translation, ncRNA-mediated (GO:0045974)3.48599497
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.48599497
16pyrimidine nucleobase catabolic process (GO:0006208)3.41644926
17lung-associated mesenchyme development (GO:0060484)3.41199377
18bundle of His cell to Purkinje myocyte communication (GO:0086069)3.36448109
19histone arginine methylation (GO:0034969)3.27423084
20heterochromatin organization (GO:0070828)3.21942365
21establishment of monopolar cell polarity (GO:0061162)3.19244849
22establishment or maintenance of monopolar cell polarity (GO:0061339)3.19244849
23regulation of telomere maintenance via telomerase (GO:0032210)3.15404066
24establishment of apical/basal cell polarity (GO:0035089)3.12708509
25regulation of histone H3-K9 methylation (GO:0051570)3.12088385
26negative regulation of gene silencing (GO:0060969)3.07272814
27positive regulation of SMAD protein import into nucleus (GO:0060391)3.06158243
28cell fate commitment involved in formation of primary germ layer (GO:0060795)3.03077762
29negative regulation of cell fate commitment (GO:0010454)3.01143580
30protein localization to kinetochore (GO:0034501)2.95233402
31regulation of gene silencing (GO:0060968)2.95188193
32DNA damage response, detection of DNA damage (GO:0042769)2.94148710
33regulation of mitotic spindle checkpoint (GO:1903504)2.93055362
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.93055362
35nuclear pore complex assembly (GO:0051292)2.92812640
36calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.91637928
37L-alpha-amino acid transmembrane transport (GO:1902475)2.91052078
38negative regulation of DNA recombination (GO:0045910)2.90234418
39inner ear receptor cell development (GO:0060119)2.90015894
40chromatin remodeling at centromere (GO:0031055)2.85126460
41regulation of cell fate commitment (GO:0010453)2.85051549
42negative regulation of cell fate specification (GO:0009996)2.84393444
43axonemal dynein complex assembly (GO:0070286)2.83277378
44telomere maintenance via telomerase (GO:0007004)2.82067456
45nucleobase catabolic process (GO:0046113)2.81648879
46lysine catabolic process (GO:0006554)2.78043574
47lysine metabolic process (GO:0006553)2.78043574
48nuclear pore organization (GO:0006999)2.77758720
49vocalization behavior (GO:0071625)2.74098944
50gap junction assembly (GO:0016264)2.74058758
51ATP-dependent chromatin remodeling (GO:0043044)2.72422853
52somatic hypermutation of immunoglobulin genes (GO:0016446)2.72000056
53somatic diversification of immune receptors via somatic mutation (GO:0002566)2.72000056
54RNA-dependent DNA replication (GO:0006278)2.71814364
55presynaptic membrane assembly (GO:0097105)2.67297064
56DNA replication-independent nucleosome organization (GO:0034724)2.66907748
57DNA replication-independent nucleosome assembly (GO:0006336)2.66907748
58serine family amino acid biosynthetic process (GO:0009070)2.66769586
59DNA double-strand break processing (GO:0000729)2.66201180
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.64890196
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64890196
62negative regulation of mitotic sister chromatid segregation (GO:0033048)2.64890196
63negative regulation of mitotic sister chromatid separation (GO:2000816)2.64890196
64negative regulation of sister chromatid segregation (GO:0033046)2.64890196
65nucleosome disassembly (GO:0006337)2.64073866
66protein-DNA complex disassembly (GO:0032986)2.64073866
67female gonad development (GO:0008585)2.62087891
68CENP-A containing nucleosome assembly (GO:0034080)2.61786038
69establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.61240897
70regulation of chromatin silencing (GO:0031935)2.60973089
71lateral sprouting from an epithelium (GO:0060601)2.60834160
72negative regulation of chromosome segregation (GO:0051985)2.59162668
73cellular protein complex localization (GO:0034629)2.54581592
74single strand break repair (GO:0000012)2.53355823
75IMP biosynthetic process (GO:0006188)2.49545175
76planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45947255
77kidney morphogenesis (GO:0060993)2.45344063
78establishment or maintenance of bipolar cell polarity (GO:0061245)2.45016710
79establishment or maintenance of apical/basal cell polarity (GO:0035088)2.45016710
80double-strand break repair via nonhomologous end joining (GO:0006303)2.44827689
81non-recombinational repair (GO:0000726)2.44827689
82convergent extension (GO:0060026)2.44718115
83histone exchange (GO:0043486)2.42572487
84presynaptic membrane organization (GO:0097090)2.41004292
85IMP metabolic process (GO:0046040)2.40801718
86apical protein localization (GO:0045176)2.40680022
87ncRNA catabolic process (GO:0034661)2.39663404
88anterior/posterior axis specification, embryo (GO:0008595)2.38397443
89DNA replication-dependent nucleosome organization (GO:0034723)2.36389939
90DNA replication-dependent nucleosome assembly (GO:0006335)2.36389939
91negative regulation of keratinocyte proliferation (GO:0010839)2.36165471
92peptidyl-arginine omega-N-methylation (GO:0035247)2.35725311
93notochord development (GO:0030903)2.35711155
94mitotic spindle checkpoint (GO:0071174)2.34212606
95negative regulation of histone methylation (GO:0031061)2.34135639
96regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.32451767
97dorsal/ventral axis specification (GO:0009950)2.32335225
98peptidyl-arginine methylation (GO:0018216)2.31918481
99peptidyl-arginine N-methylation (GO:0035246)2.31918481
100nucleotide-sugar biosynthetic process (GO:0009226)2.31446170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.37822852
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.13423160
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.95863225
4NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.69248257
5POU5F1_16153702_ChIP-ChIP_HESCs_Human2.67441289
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.48418146
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.48418146
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.48418146
9SOX2_16153702_ChIP-ChIP_HESCs_Human2.43821855
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.41578051
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33791564
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.28643366
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.25821247
14NANOG_16153702_ChIP-ChIP_HESCs_Human2.25386913
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24948684
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23632392
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20495030
18SOX2_18555785_ChIP-Seq_MESCs_Mouse2.15879275
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08887366
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01936276
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.95544698
22TCF3_18692474_ChIP-Seq_MEFs_Mouse1.88754461
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.88492556
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81048303
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.73455633
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72778814
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63702873
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63549813
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62362514
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61125219
31TCF3_18692474_ChIP-Seq_MESCs_Mouse1.60508562
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57689327
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56643694
34SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.51626792
35ZNF274_21170338_ChIP-Seq_K562_Hela1.48174553
36FUS_26573619_Chip-Seq_HEK293_Human1.47967560
37POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.47413393
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46859677
39AR_21909140_ChIP-Seq_LNCAP_Human1.46358435
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44152242
41SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.42679740
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37100031
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36438107
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36087990
45EWS_26573619_Chip-Seq_HEK293_Human1.35660005
46NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.34012548
47NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31784485
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28979633
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28764350
50TBX3_20139965_ChIP-Seq_ESCs_Mouse1.28102386
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28083941
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.27218632
53TBX3_20139965_ChIP-Seq_MESCs_Mouse1.26694110
54IGF1R_20145208_ChIP-Seq_DFB_Human1.26319762
55STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24567957
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24299263
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.22406908
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21687044
59NANOG_21062744_ChIP-ChIP_HESCs_Human1.20522058
60P300_19829295_ChIP-Seq_ESCs_Human1.19612900
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18522218
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18475753
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16324840
64TAF15_26573619_Chip-Seq_HEK293_Human1.16252647
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15832590
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15494026
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15200113
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14909741
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12330837
70TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.12131365
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12080476
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08392152
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.07821724
74ELK1_19687146_ChIP-ChIP_HELA_Human1.07751617
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07692172
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06356070
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06295196
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.03808386
79SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03542119
80IRF1_19129219_ChIP-ChIP_H3396_Human1.02393776
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02345496
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01935278
83PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01371441
84SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01358030
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.00853986
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00624012
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97535236
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96235000
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96235000
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96120016
91MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95038939
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94504288
93MYC_18940864_ChIP-ChIP_HL60_Human0.93099905
94NANOG_18692474_ChIP-Seq_MESCs_Mouse0.92976054
95NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90714887
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.90695780
97XRN2_22483619_ChIP-Seq_HELA_Human0.90643420
98THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90349750
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.88702361
100NANOG_16518401_ChIP-PET_MESCs_Mouse0.88686441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.55808480
2MP0002254_reproductive_system_inflammat3.60176625
3MP0001188_hyperpigmentation2.95037017
4MP0003890_abnormal_embryonic-extraembry2.93295358
5MP0003693_abnormal_embryo_hatching2.71736315
6MP0000579_abnormal_nail_morphology2.41566619
7MP0008877_abnormal_DNA_methylation2.38400074
8MP0009672_abnormal_birth_weight2.34865466
9MP0004957_abnormal_blastocyst_morpholog2.32196184
10MP0000566_synostosis2.20096286
11MP0003787_abnormal_imprinting2.03688033
12MP0004133_heterotaxia2.02107758
13MP0002796_impaired_skin_barrier2.00882349
14MP0003122_maternal_imprinting1.97515009
15MP0004264_abnormal_extraembryonic_tissu1.92779548
16MP0003119_abnormal_digestive_system1.87393360
17MP0003937_abnormal_limbs/digits/tail_de1.82544016
18MP0008932_abnormal_embryonic_tissue1.80780294
19MP0003567_abnormal_fetal_cardiomyocyte1.77734538
20MP0000537_abnormal_urethra_morphology1.77419573
21MP0003121_genomic_imprinting1.73909738
22MP0010352_gastrointestinal_tract_polyps1.69742407
23MP0001293_anophthalmia1.68625548
24MP0010234_abnormal_vibrissa_follicle1.68420985
25MP0003718_maternal_effect1.64165194
26MP0005394_taste/olfaction_phenotype1.61192616
27MP0005499_abnormal_olfactory_system1.61192616
28MP0001529_abnormal_vocalization1.59232294
29MP0002697_abnormal_eye_size1.56847118
30MP0008789_abnormal_olfactory_epithelium1.56779562
31MP0009703_decreased_birth_body1.55301346
32MP0008058_abnormal_DNA_repair1.53173343
33MP0003111_abnormal_nucleus_morphology1.44624095
34MP0003123_paternal_imprinting1.44560709
35MP0004270_analgesia1.41043713
36MP0002822_catalepsy1.40788254
37MP0001299_abnormal_eye_distance/1.39538632
38MP0002233_abnormal_nose_morphology1.39277519
39MP0002084_abnormal_developmental_patter1.38901107
40MP0008057_abnormal_DNA_replication1.38019106
41MP0002085_abnormal_embryonic_tissue1.35843401
42MP0000049_abnormal_middle_ear1.35475782
43MP0001984_abnormal_olfaction1.35396257
44MP0001730_embryonic_growth_arrest1.33931031
45MP0001286_abnormal_eye_development1.30666495
46MP0002751_abnormal_autonomic_nervous1.28739636
47MP0010094_abnormal_chromosome_stability1.28033346
48MP0003861_abnormal_nervous_system1.27865261
49MP0000778_abnormal_nervous_system1.25112547
50MP0006292_abnormal_olfactory_placode1.22434990
51MP0001485_abnormal_pinna_reflex1.21148888
52MP0010678_abnormal_skin_adnexa1.19297306
53MP0004197_abnormal_fetal_growth/weight/1.18263032
54MP0010030_abnormal_orbit_morphology1.14209466
55MP0000383_abnormal_hair_follicle1.13992202
56MP0003077_abnormal_cell_cycle1.13643658
57MP0003938_abnormal_ear_development1.12883937
58MP0000647_abnormal_sebaceous_gland1.12516141
59MP0006276_abnormal_autonomic_nervous1.11167542
60MP0005501_abnormal_skin_physiology1.09670142
61MP0000762_abnormal_tongue_morphology1.09288851
62MP0005380_embryogenesis_phenotype1.08313492
63MP0001672_abnormal_embryogenesis/_devel1.08313492
64MP0002111_abnormal_tail_morphology1.07515202
65MP0002098_abnormal_vibrissa_morphology1.05212265
66MP0002653_abnormal_ependyma_morphology1.05116622
67MP0001849_ear_inflammation1.04685381
68MP0003136_yellow_coat_color1.03363000
69MP0003315_abnormal_perineum_morphology1.02711686
70MP0002102_abnormal_ear_morphology1.01831665
71MP0003755_abnormal_palate_morphology1.01583455
72MP0003878_abnormal_ear_physiology1.00628575
73MP0005377_hearing/vestibular/ear_phenot1.00628575
74MP0000467_abnormal_esophagus_morphology0.96088270
75MP0001177_atelectasis0.95324666
76MP0003984_embryonic_growth_retardation0.90841639
77MP0002088_abnormal_embryonic_growth/wei0.90146725
78MP0001697_abnormal_embryo_size0.89941996
79MP0000350_abnormal_cell_proliferation0.87523658
80MP0003221_abnormal_cardiomyocyte_apopto0.86164331
81MP0008007_abnormal_cellular_replicative0.85286633
82MP0002080_prenatal_lethality0.83529338
83MP0000377_abnormal_hair_follicle0.83302086
84MP0004043_abnormal_pH_regulation0.82632201
85MP0002184_abnormal_innervation0.82493174
86MP0003880_abnormal_central_pattern0.82359000
87MP0000631_abnormal_neuroendocrine_gland0.80592041
88MP0002081_perinatal_lethality0.78295638
89MP0000432_abnormal_head_morphology0.76448870
90MP0002092_abnormal_eye_morphology0.76410064
91MP0005248_abnormal_Harderian_gland0.76363473
92MP0000462_abnormal_digestive_system0.75243847
93MP0000955_abnormal_spinal_cord0.74739798
94MP0002736_abnormal_nociception_after0.73203528
95MP0002152_abnormal_brain_morphology0.72867486
96MP0003115_abnormal_respiratory_system0.72310785
97MP0002734_abnormal_mechanical_nocicepti0.71176363
98MP0004782_abnormal_surfactant_physiolog0.70299099
99MP0002938_white_spotting0.69824866
100MP0003935_abnormal_craniofacial_develop0.69545332

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)4.79496527
2Abnormality of the labia minora (HP:0012880)4.21295591
3Cortical dysplasia (HP:0002539)3.62903734
4Colon cancer (HP:0003003)3.53556669
5Hepatoblastoma (HP:0002884)3.52625911
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.97931496
7Ependymoma (HP:0002888)2.86627222
8Stenosis of the external auditory canal (HP:0000402)2.84157979
9Choanal stenosis (HP:0000452)2.80123327
10Septo-optic dysplasia (HP:0100842)2.76381150
11Labial hypoplasia (HP:0000066)2.67737635
12Hyperactive renin-angiotensin system (HP:0000841)2.67582411
13Absent eyebrow (HP:0002223)2.66302135
14Spastic diplegia (HP:0001264)2.65940809
15Hypoplastic female external genitalia (HP:0012815)2.64489654
16Abnormal respiratory epithelium morphology (HP:0012253)2.46243871
17Abnormal respiratory motile cilium morphology (HP:0005938)2.46243871
18Nephroblastoma (Wilms tumor) (HP:0002667)2.44183166
19Right ventricular cardiomyopathy (HP:0011663)2.44121499
20Rhinitis (HP:0012384)2.41161855
21Myelomeningocele (HP:0002475)2.39111608
22Bilateral microphthalmos (HP:0007633)2.36071468
23Absent eyelashes (HP:0000561)2.34631808
24Hyperglycinemia (HP:0002154)2.32293861
25Abnormal respiratory motile cilium physiology (HP:0012261)2.30489075
26Abnormal lung lobation (HP:0002101)2.27561111
27Embryonal renal neoplasm (HP:0011794)2.24347023
28Medulloblastoma (HP:0002885)2.23787152
29Aplasia/Hypoplasia of the sternum (HP:0006714)2.22865137
30Bifid tongue (HP:0010297)2.18470415
31Scrotal hypoplasia (HP:0000046)2.16620784
32Pili torti (HP:0003777)2.12952406
33Rhabdomyosarcoma (HP:0002859)2.11929746
34Facial cleft (HP:0002006)2.11146064
35Biliary tract neoplasm (HP:0100574)2.08993636
36Multiple enchondromatosis (HP:0005701)2.06702511
37Breast carcinoma (HP:0003002)2.03161417
38Abnormal ciliary motility (HP:0012262)2.03056099
39Renal hypoplasia (HP:0000089)1.99838427
40Abnormality of the labia (HP:0000058)1.99731138
41Abnormal hair whorl (HP:0010721)1.99095278
42Selective tooth agenesis (HP:0001592)1.98254185
43Failure to thrive in infancy (HP:0001531)1.97964087
44Esophageal atresia (HP:0002032)1.97890131
45Maternal diabetes (HP:0009800)1.97824893
46Absent hair (HP:0002298)1.96953180
47Carpal bone hypoplasia (HP:0001498)1.95805234
48Abnormality of the astrocytes (HP:0100707)1.94172584
49Astrocytoma (HP:0009592)1.94172584
50Generalized hypotonia (HP:0001290)1.91321198
51Vaginal atresia (HP:0000148)1.91215215
52Cutaneous syndactyly (HP:0012725)1.90923640
53Abnormality of glycine metabolism (HP:0010895)1.90527132
54Abnormality of serine family amino acid metabolism (HP:0010894)1.90527132
55Gastrointestinal carcinoma (HP:0002672)1.90200057
56Malignant gastrointestinal tract tumors (HP:0006749)1.90200057
57Abnormality of the septum pellucidum (HP:0007375)1.88667487
58Curly hair (HP:0002212)1.87696033
59Absent septum pellucidum (HP:0001331)1.85011630
60Cutaneous finger syndactyly (HP:0010554)1.85006452
61Abnormality of the salivary glands (HP:0010286)1.84516047
62Absent/shortened dynein arms (HP:0200106)1.84416695
63Dynein arm defect of respiratory motile cilia (HP:0012255)1.84416695
64Birth length less than 3rd percentile (HP:0003561)1.83830645
65Genital tract atresia (HP:0001827)1.83751083
66Glioma (HP:0009733)1.83507070
67Anophthalmia (HP:0000528)1.82594600
68Bronchiectasis (HP:0002110)1.81718289
69Bronchomalacia (HP:0002780)1.80288065
70Bicornuate uterus (HP:0000813)1.79129006
71Shoulder girdle muscle weakness (HP:0003547)1.78841497
72High anterior hairline (HP:0009890)1.78259982
73Hyperglycinuria (HP:0003108)1.77982826
74Abnormality of serum amino acid levels (HP:0003112)1.75503977
75Hypoplastic labia majora (HP:0000059)1.75428573
76Split foot (HP:0001839)1.72061771
77Abnormality of permanent molar morphology (HP:0011071)1.71965720
78Abnormality of the dental root (HP:0006486)1.71965720
79Taurodontia (HP:0000679)1.71965720
80Hypoglycemic seizures (HP:0002173)1.70619684
81Clitoromegaly (HP:0000057)1.70534777
82Cupped ear (HP:0000378)1.70027265
83Abnormality of the clitoris (HP:0000056)1.69477671
84Abnormality of the lacrimal duct (HP:0011481)1.67502412
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66870752
86Breast aplasia (HP:0100783)1.66704739
87Aqueductal stenosis (HP:0002410)1.65252478
88Uterine neoplasm (HP:0010784)1.64821590
89Impaired vibration sensation in the lower limbs (HP:0002166)1.64709608
90Thyroid-stimulating hormone excess (HP:0002925)1.64424490
91Urinary urgency (HP:0000012)1.63312550
92Long foot (HP:0001833)1.62348594
93Absent radius (HP:0003974)1.61884935
94Neoplasm of the adrenal gland (HP:0100631)1.61361126
95Neoplasm of the adrenal cortex (HP:0100641)1.60734797
96Broad foot (HP:0001769)1.60644644
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.59775409
98Absent forearm bone (HP:0003953)1.59453995
99Aplasia involving forearm bones (HP:0009822)1.59453995
100Abnormal pancreas size (HP:0012094)1.57051267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.10315219
2BCR3.05995851
3CASK2.81289902
4TTK2.76642688
5WNK32.71556414
6TRIM282.66782184
7SRPK12.63152992
8DYRK22.37022770
9CDC72.35103823
10EPHA22.33060770
11DYRK32.11155481
12TAF12.10514953
13MAP3K42.06023732
14MKNK12.03594596
15MKNK22.00095813
16TNIK1.99969849
17MAP3K101.82326837
18MAP2K71.79948998
19BUB11.74608900
20STK38L1.73121241
21MST41.67856407
22PLK31.63328037
23CDK191.58530067
24PASK1.58349519
25ZAK1.51525131
26MARK11.41412561
27LATS11.29927487
28OXSR11.29024022
29NME11.25982564
30CSNK1G11.24918755
31PBK1.24656086
32STK241.22302713
33CSNK1G21.13545293
34PLK11.13519847
35VRK21.12978551
36NEK11.06579011
37FGFR21.04642880
38FGFR11.01300330
39CSNK1G31.00263414
40LATS20.96385344
41MINK10.91637191
42PLK40.90981310
43ERBB30.90633767
44BRSK20.89993412
45CSNK1A1L0.88450281
46RPS6KA40.87284717
47LMTK20.87136194
48ALK0.84494003
49NUAK10.83999306
50MAPK150.83248326
51SMG10.79713642
52VRK10.77869677
53CSNK1E0.77282445
54PAK40.76930868
55STK160.75074371
56MET0.74893542
57DYRK1A0.74528651
58NTRK10.74316079
59MAP3K90.73518518
60STK30.69162217
61CHEK20.65828762
62SIK30.64558802
63ATR0.64013336
64MAP4K20.61678333
65ATM0.60326196
66MST1R0.57192231
67NEK20.55043932
68ERBB20.54903093
69AURKB0.54379470
70CAMK1D0.52933659
71SGK4940.52523878
72SGK2230.52523878
73PRKDC0.51569066
74MAP3K60.50625761
75TESK10.50235417
76DYRK1B0.49986135
77PIK3CA0.48769068
78EGFR0.48260600
79NLK0.48059346
80DMPK0.47378650
81PRKCE0.46428296
82WEE10.46408221
83BRD40.45271465
84FER0.45202641
85EEF2K0.44964631
86CHEK10.44869685
87UHMK10.43501396
88CAMK1G0.43303418
89CSNK1A10.43206634
90CDK10.43024973
91CDK180.42988197
92EPHA30.42661574
93ERBB40.42574897
94MAP2K40.41421869
95CDK20.41321254
96YES10.41180823
97ACVR1B0.40632883
98PRKCI0.39807417
99PRKCG0.39170653
100PTK20.39115858

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.48980770
2Mismatch repair_Homo sapiens_hsa034302.29261011
3Non-homologous end-joining_Homo sapiens_hsa034502.24499064
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.14302421
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09883066
6Cysteine and methionine metabolism_Homo sapiens_hsa002702.08021542
7Selenocompound metabolism_Homo sapiens_hsa004501.86336233
8RNA transport_Homo sapiens_hsa030131.82044356
9Tight junction_Homo sapiens_hsa045301.81370855
10DNA replication_Homo sapiens_hsa030301.81010103
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80552159
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77690588
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67320522
14Spliceosome_Homo sapiens_hsa030401.66164155
15Biosynthesis of amino acids_Homo sapiens_hsa012301.60782605
16mRNA surveillance pathway_Homo sapiens_hsa030151.59628920
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58882990
18Adherens junction_Homo sapiens_hsa045201.54040333
19Vitamin B6 metabolism_Homo sapiens_hsa007501.51409768
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48141701
21Cell cycle_Homo sapiens_hsa041101.47807124
22Base excision repair_Homo sapiens_hsa034101.42450121
23Proteasome_Homo sapiens_hsa030501.42053935
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39761767
25Hippo signaling pathway_Homo sapiens_hsa043901.35592831
26Propanoate metabolism_Homo sapiens_hsa006401.34926826
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.29737670
28Pyruvate metabolism_Homo sapiens_hsa006201.29217842
29Nicotine addiction_Homo sapiens_hsa050331.28583919
30Basal transcription factors_Homo sapiens_hsa030221.27180990
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25180587
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20566625
33Thyroid cancer_Homo sapiens_hsa052161.19890938
34RNA polymerase_Homo sapiens_hsa030201.17565239
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17315866
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16037176
37Caffeine metabolism_Homo sapiens_hsa002321.15064929
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14327215
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12424697
40Protein export_Homo sapiens_hsa030601.12121649
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09816155
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07403327
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07382892
44RNA degradation_Homo sapiens_hsa030181.06984983
45Axon guidance_Homo sapiens_hsa043601.06766574
46Basal cell carcinoma_Homo sapiens_hsa052171.04564887
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01388879
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00008402
49Carbon metabolism_Homo sapiens_hsa012000.96577436
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94982299
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.94645527
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94345426
53Wnt signaling pathway_Homo sapiens_hsa043100.93270379
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91208062
55Retinol metabolism_Homo sapiens_hsa008300.85760799
56Fanconi anemia pathway_Homo sapiens_hsa034600.85624035
57Huntingtons disease_Homo sapiens_hsa050160.85561307
58Arginine and proline metabolism_Homo sapiens_hsa003300.83290238
59Glutathione metabolism_Homo sapiens_hsa004800.83166652
60beta-Alanine metabolism_Homo sapiens_hsa004100.82184707
61One carbon pool by folate_Homo sapiens_hsa006700.81874055
62Starch and sucrose metabolism_Homo sapiens_hsa005000.80795767
63Vitamin digestion and absorption_Homo sapiens_hsa049770.78829962
64Oocyte meiosis_Homo sapiens_hsa041140.78531014
65Histidine metabolism_Homo sapiens_hsa003400.77486173
66Taste transduction_Homo sapiens_hsa047420.76343262
67Fatty acid elongation_Homo sapiens_hsa000620.74059591
68Galactose metabolism_Homo sapiens_hsa000520.70749882
69Homologous recombination_Homo sapiens_hsa034400.70654168
70Nucleotide excision repair_Homo sapiens_hsa034200.70135380
71Colorectal cancer_Homo sapiens_hsa052100.68423234
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66430449
73Lysine degradation_Homo sapiens_hsa003100.64840588
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.64762593
75Hedgehog signaling pathway_Homo sapiens_hsa043400.64559088
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63936696
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62293366
78Phenylalanine metabolism_Homo sapiens_hsa003600.58576643
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57578502
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56496013
81Metabolic pathways_Homo sapiens_hsa011000.55616297
82Arginine biosynthesis_Homo sapiens_hsa002200.53371431
83Phototransduction_Homo sapiens_hsa047440.53220117
84Chemical carcinogenesis_Homo sapiens_hsa052040.52934023
85Fat digestion and absorption_Homo sapiens_hsa049750.52749950
86Purine metabolism_Homo sapiens_hsa002300.52132991
87Tyrosine metabolism_Homo sapiens_hsa003500.51143760
88TGF-beta signaling pathway_Homo sapiens_hsa043500.50039652
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49996702
90Pyrimidine metabolism_Homo sapiens_hsa002400.49102190
91Butanoate metabolism_Homo sapiens_hsa006500.48400316
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44545396
93Parkinsons disease_Homo sapiens_hsa050120.44143203
94p53 signaling pathway_Homo sapiens_hsa041150.42881815
95Alcoholism_Homo sapiens_hsa050340.42238972
96Sulfur metabolism_Homo sapiens_hsa009200.42001986
97Fatty acid degradation_Homo sapiens_hsa000710.41107822
98Ether lipid metabolism_Homo sapiens_hsa005650.40591046
99Fatty acid metabolism_Homo sapiens_hsa012120.40326004
100Endometrial cancer_Homo sapiens_hsa052130.39433153

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