CD244

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)5.60073838
2antigen processing and presentation of endogenous antigen (GO:0019883)5.55910331
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.50261878
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.50261878
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.23965090
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.03692967
7positive regulation of gamma-delta T cell activation (GO:0046645)4.80116648
8detection of other organism (GO:0098543)4.54437865
9interferon-gamma production (GO:0032609)4.44710673
10detection of bacterium (GO:0016045)4.42373729
11cellular extravasation (GO:0045123)4.35910818
12immunoglobulin mediated immune response (GO:0016064)4.27769213
13regulation of B cell differentiation (GO:0045577)4.25416324
14positive regulation of B cell differentiation (GO:0045579)4.13980529
15microglial cell activation (GO:0001774)4.11529818
16mast cell activation (GO:0045576)4.08867391
17neutrophil activation involved in immune response (GO:0002283)4.04632064
18negative regulation of phagocytosis (GO:0050765)4.03951039
19negative regulation of lymphocyte mediated immunity (GO:0002707)3.94043446
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.90718963
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.90718963
22modulation by symbiont of host immune response (GO:0052553)3.90718963
23positive regulation by symbiont of host defense response (GO:0052509)3.90718963
24modulation by symbiont of host defense response (GO:0052031)3.90718963
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.90718963
26negative regulation of erythrocyte differentiation (GO:0045647)3.87863893
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.83959448
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.78764717
29B cell receptor signaling pathway (GO:0050853)3.73929562
30leukocyte aggregation (GO:0070486)3.73055712
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.72322027
32negative regulation of cell killing (GO:0031342)3.72322027
33negative regulation of leukocyte mediated immunity (GO:0002704)3.69265060
34regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.68694590
35detection of external biotic stimulus (GO:0098581)3.64015878
36positive T cell selection (GO:0043368)3.58893985
37negative regulation of T cell mediated immunity (GO:0002710)3.56258652
38regulation of myeloid leukocyte mediated immunity (GO:0002886)3.51691458
39ribosomal small subunit assembly (GO:0000028)3.47654153
40regulation of interferon-beta biosynthetic process (GO:0045357)3.45886568
41positive regulation of granulocyte differentiation (GO:0030854)3.43079726
42regulation of leukocyte degranulation (GO:0043300)3.39673395
43respiratory burst (GO:0045730)3.38230775
44positive regulation of antigen processing and presentation (GO:0002579)3.35286425
45B cell mediated immunity (GO:0019724)3.34914984
46T cell selection (GO:0045058)3.30380116
47production of molecular mediator involved in inflammatory response (GO:0002532)3.29872979
48negative regulation of interleukin-12 production (GO:0032695)3.29017402
49macrophage activation (GO:0042116)3.28986876
50detection of biotic stimulus (GO:0009595)3.28435475
51positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.28066359
52T cell migration (GO:0072678)3.26924631
53response to peptidoglycan (GO:0032494)3.25950454
54regulation of T cell receptor signaling pathway (GO:0050856)3.25314362
55defense response to protozoan (GO:0042832)3.22686804
56actin nucleation (GO:0045010)3.20863362
57neutrophil activation (GO:0042119)3.20853917
58myeloid dendritic cell activation (GO:0001773)3.20100270
59response to protozoan (GO:0001562)3.19143510
60regulation of gamma-delta T cell differentiation (GO:0045586)3.18303374
61myeloid cell activation involved in immune response (GO:0002275)3.17643222
62positive regulation of mast cell degranulation (GO:0043306)3.17415722
63regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.15369501
64regulation of natural killer cell mediated immunity (GO:0002715)3.15369501
65regulation of gamma-delta T cell activation (GO:0046643)3.15340393
66antigen processing and presentation via MHC class Ib (GO:0002475)3.10742114
67positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10584764
68regulation of regulatory T cell differentiation (GO:0045589)3.10164487
69negative regulation of innate immune response (GO:0045824)3.10059579
70negative thymic T cell selection (GO:0045060)3.09481080
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09330292
72cellular defense response (GO:0006968)3.09010748
73detection of molecule of bacterial origin (GO:0032490)3.08374840
74negative regulation of granulocyte differentiation (GO:0030853)3.06470923
75regulation of T cell mediated cytotoxicity (GO:0001914)3.06055122
76thymic T cell selection (GO:0045061)3.05669515
77regulation of mast cell activation (GO:0033003)3.04931172
78positive regulation of mast cell activation (GO:0033005)3.04444331
79regulation of tolerance induction (GO:0002643)3.03845365
80response to host (GO:0075136)3.03345713
81response to host defenses (GO:0052200)3.03345713
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.03345713
83activated T cell proliferation (GO:0050798)3.02111448
84germinal center formation (GO:0002467)2.98953957
85mast cell activation involved in immune response (GO:0002279)2.98568265
86mast cell degranulation (GO:0043303)2.98568265
87T cell homeostasis (GO:0043029)2.98230902
88cellular response to interferon-beta (GO:0035458)2.97626366
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97443510
90response to muramyl dipeptide (GO:0032495)2.97306972
91antigen receptor-mediated signaling pathway (GO:0050851)2.97052053
92megakaryocyte development (GO:0035855)2.95173150
93granulocyte activation (GO:0036230)2.94758625
94positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94324267
95positive thymic T cell selection (GO:0045059)2.93971470
96positive regulation of isotype switching (GO:0045830)2.93368554
97regulation of mast cell degranulation (GO:0043304)2.93182837
98cellular response to exogenous dsRNA (GO:0071360)2.92932479
99regulation of antigen processing and presentation (GO:0002577)2.92401449
100negative T cell selection (GO:0043383)2.91506765
101dendritic cell migration (GO:0036336)2.90875450
102lymphoid progenitor cell differentiation (GO:0002320)2.89629055
103regulation of regulated secretory pathway (GO:1903305)2.89620253
104positive regulation of alpha-beta T cell proliferation (GO:0046641)2.89515842
105leukocyte cell-cell adhesion (GO:0007159)2.88260335
106dendritic cell chemotaxis (GO:0002407)2.87682128
107cell wall macromolecule catabolic process (GO:0016998)2.87452757
108positive regulation of interferon-alpha production (GO:0032727)2.86626997
109response to interferon-beta (GO:0035456)2.84924203
110type I interferon signaling pathway (GO:0060337)2.84362349
111cellular response to type I interferon (GO:0071357)2.84362349
112macrophage activation involved in immune response (GO:0002281)2.84339330
113response to interleukin-15 (GO:0070672)2.83751541
114regulation of T cell tolerance induction (GO:0002664)2.83688375
115negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.82065866
116leukocyte degranulation (GO:0043299)2.79123824
117pinocytosis (GO:0006907)2.78034961
118response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75086480
119response to host immune response (GO:0052572)2.75086480
120cellular response to interleukin-15 (GO:0071350)2.74907980
121regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73229743
122interferon-gamma-mediated signaling pathway (GO:0060333)2.72408550
123natural killer cell activation (GO:0030101)2.72200332
124mature B cell differentiation (GO:0002335)2.72140183
125regulation of leukocyte mediated cytotoxicity (GO:0001910)2.71819729
126positive regulation of defense response to virus by host (GO:0002230)2.70592005
127regulation of interferon-alpha production (GO:0032647)2.70164102
128neutrophil mediated immunity (GO:0002446)2.66691787
129angiogenesis involved in wound healing (GO:0060055)2.66553240
130myeloid leukocyte activation (GO:0002274)2.65249440
131mature B cell differentiation involved in immune response (GO:0002313)2.65215113
132regulation of mast cell activation involved in immune response (GO:0033006)2.64087820
133positive regulation of T cell chemotaxis (GO:0010820)2.63936853
134regulation of T cell chemotaxis (GO:0010819)2.63936853
135myeloid dendritic cell differentiation (GO:0043011)2.63346151
136DNA deamination (GO:0045006)2.63029039
137regulation of alpha-beta T cell proliferation (GO:0046640)2.62720009
138positive regulation of mast cell activation involved in immune response (GO:0033008)2.62404465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.12787807
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.44819645
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.44397073
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.37723546
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.79272464
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.71236082
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.58000668
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.52976393
9SCL_19346495_ChIP-Seq_HPC-7_Human3.12589593
10* IRF8_27001747_Chip-Seq_BMDM_Mouse3.09450919
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.08944225
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.04655244
13* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.96366273
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85254975
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.74788657
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.74597416
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.63603813
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.62610802
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60749118
20* MYB_26560356_Chip-Seq_TH2_Human2.56582910
21* SPI1_23547873_ChIP-Seq_NB4_Human2.55421273
22VDR_21846776_ChIP-Seq_THP-1_Human2.53960560
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39175793
24* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.26875752
25* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.25798506
26MYC_22102868_ChIP-Seq_BL_Human2.25740937
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21265953
28VDR_24763502_ChIP-Seq_THP-1_Human2.17284794
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.14950606
30* MAF_26560356_Chip-Seq_TH1_Human2.11038213
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08620976
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07588778
33MYB_26560356_Chip-Seq_TH1_Human2.06081045
34RUNX_20019798_ChIP-Seq_JUKART_Human2.00153833
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90804430
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87493027
37* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.87287231
38* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83934028
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82946034
40UTX_26944678_Chip-Seq_JUKART_Human1.78888168
41GATA1_22025678_ChIP-Seq_K562_Human1.77423979
42* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77003257
43* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.76911529
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76555574
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75843057
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.73557929
47SPI1_23127762_ChIP-Seq_K562_Human1.67649372
48* TCF7_22412390_ChIP-Seq_EML_Mouse1.59905971
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58886693
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56596201
51* NOTCH1_21737748_ChIP-Seq_TLL_Human1.54800475
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.51228647
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49535628
54* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48090930
55GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47110523
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46982213
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.45787365
58* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44384095
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44005792
60* PU_27001747_Chip-Seq_BMDM_Mouse1.41608984
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41322179
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39899845
63* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.39896185
64GATA1_19941826_ChIP-Seq_K562_Human1.39790750
65GATA3_27048872_Chip-Seq_THYMUS_Human1.38729250
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37094554
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.36486955
68* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36171174
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35440502
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33173457
71* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31268451
72MAF_26560356_Chip-Seq_TH2_Human1.27245338
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25179010
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22229117
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.21925325
76* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21831321
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19309537
78GATA3_26560356_Chip-Seq_TH2_Human1.12911918
79VDR_23849224_ChIP-Seq_CD4+_Human1.12701734
80GATA2_19941826_ChIP-Seq_K562_Human1.12629932
81* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12119674
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11079486
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09113838
84BCL6_27268052_Chip-Seq_Bcells_Human1.07842077
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05181820
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.04869308
87* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04016267
88MYC_18555785_ChIP-Seq_MESCs_Mouse1.02967954
89FOXP3_21729870_ChIP-Seq_TREG_Human1.02202457
90* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01830242
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00604271
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99793357
93E2F1_21310950_ChIP-Seq_MCF-7_Human0.98643032
94CIITA_25753668_ChIP-Seq_RAJI_Human0.97664454
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.95123159
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95076820
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94401763
98* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93060653
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92986658
100BCOR_27268052_Chip-Seq_Bcells_Human0.91968236
101STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87091573
102NCOR1_26117541_ChIP-Seq_K562_Human0.86864392
103* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84994780
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.84899838
105P300_27268052_Chip-Seq_Bcells_Human0.83496930
106STAT1_20625510_ChIP-Seq_HELA_Human0.82576177
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81680641
108VDR_24787735_ChIP-Seq_THP-1_Human0.81585860
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.80509750
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.80146061
111ELK1_19687146_ChIP-ChIP_HELA_Human0.80088382
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78284910
113SPI1_20517297_ChIP-Seq_HL60_Human0.77060439
114ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76914053
115RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74105269
116KDM2B_26808549_Chip-Seq_DND41_Human0.73546045
117MYC_18358816_ChIP-ChIP_MESCs_Mouse0.71878091
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70462190
119EST1_17652178_ChIP-ChIP_JURKAT_Human0.69630013
120MYC_19079543_ChIP-ChIP_MESCs_Mouse0.68841980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.77783334
2MP0002396_abnormal_hematopoietic_system3.64546361
3MP0005671_abnormal_response_to3.61783234
4MP0009785_altered_susceptibility_to3.29640599
5MP0003436_decreased_susceptibility_to3.08593322
6MP0005025_abnormal_response_to3.03144094
7MP0005000_abnormal_immune_tolerance2.99290990
8MP0001800_abnormal_humoral_immune2.97726264
9MP0002419_abnormal_innate_immunity2.89368656
10MP0002148_abnormal_hypersensitivity_rea2.88204811
11MP0002452_abnormal_antigen_presenting2.80015585
12MP0001790_abnormal_immune_system2.77669310
13MP0005387_immune_system_phenotype2.77669310
14* MP0002420_abnormal_adaptive_immunity2.70431383
15MP0000685_abnormal_immune_system2.70260232
16* MP0001819_abnormal_immune_cell2.70247639
17MP0002723_abnormal_immune_serum2.68256855
18MP0002398_abnormal_bone_marrow2.35801875
19MP0006082_CNS_inflammation2.34337328
20MP0001853_heart_inflammation2.32997050
21MP0005464_abnormal_platelet_physiology2.26486426
22MP0003724_increased_susceptibility_to2.23807309
23MP0003763_abnormal_thymus_physiology2.23795047
24MP0002405_respiratory_system_inflammati2.21175940
25MP0003303_peritoneal_inflammation2.19426376
26MP0000716_abnormal_immune_system2.19059728
27MP0009333_abnormal_splenocyte_physiolog2.08216648
28MP0000689_abnormal_spleen_morphology2.01893828
29MP0005174_abnormal_tail_pigmentation1.96914065
30MP0002166_altered_tumor_susceptibility1.95479364
31MP0010155_abnormal_intestine_physiology1.94280620
32MP0005397_hematopoietic_system_phenotyp1.91713169
33MP0001545_abnormal_hematopoietic_system1.91713169
34MP0002722_abnormal_immune_system1.91180597
35MP0002429_abnormal_blood_cell1.86790614
36MP0000465_gastrointestinal_hemorrhage1.85447519
37MP0001845_abnormal_inflammatory_respons1.82398193
38MP0002006_tumorigenesis1.79415140
39MP0000858_altered_metastatic_potential1.79252661
40MP0000490_abnormal_crypts_of1.76784159
41MP0004808_abnormal_hematopoietic_stem1.72757647
42MP0001873_stomach_inflammation1.66100853
43MP0009278_abnormal_bone_marrow1.62943156
44MP0003448_altered_tumor_morphology1.59703481
45MP0004947_skin_inflammation1.58553731
46MP0003172_abnormal_lysosome_physiology1.57928728
47MP0005075_abnormal_melanosome_morpholog1.54738051
48MP0004510_myositis1.54326677
49MP0000703_abnormal_thymus_morphology1.50544063
50MP0003300_gastrointestinal_ulcer1.50542195
51MP0003866_abnormal_defecation1.48430668
52MP0001533_abnormal_skeleton_physiology1.48353706
53MP0008469_abnormal_protein_level1.44900495
54MP0008260_abnormal_autophagy1.40461487
55MP0010307_abnormal_tumor_latency1.34953900
56MP0000343_altered_response_to1.33238507
57MP0002933_joint_inflammation1.33105484
58MP0003183_abnormal_peptide_metabolism1.31906939
59MP0008057_abnormal_DNA_replication1.28694049
60MP0005058_abnormal_lysosome_morphology1.27508721
61MP0003806_abnormal_nucleotide_metabolis1.19098801
62MP0009764_decreased_sensitivity_to1.16200436
63MP0003690_abnormal_glial_cell1.16148724
64MP0002019_abnormal_tumor_incidence1.13272488
65MP0001986_abnormal_taste_sensitivity1.11913414
66MP0010094_abnormal_chromosome_stability1.11625374
67MP0005310_abnormal_salivary_gland1.10025740
68MP0010352_gastrointestinal_tract_polyps1.03219221
69MP0001851_eye_inflammation1.02142562
70MP0008004_abnormal_stomach_pH0.99536860
71MP0002132_abnormal_respiratory_system0.99303365
72MP0003075_altered_response_to0.98851797
73MP0003693_abnormal_embryo_hatching0.98626383
74MP0002095_abnormal_skin_pigmentation0.91453128
75MP0004381_abnormal_hair_follicle0.90770997
76MP0002998_abnormal_bone_remodeling0.89946690
77MP0008007_abnormal_cellular_replicative0.88613410
78MP0009763_increased_sensitivity_to0.87648311
79MP0003787_abnormal_imprinting0.86879561
80MP0005164_abnormal_response_to0.84408869
81MP0005166_decreased_susceptibility_to0.83077968
82MP0002277_abnormal_respiratory_mucosa0.82526412
83MP0003828_pulmonary_edema0.80431720
84MP0002009_preneoplasia0.80265029
85MP0000015_abnormal_ear_pigmentation0.80147349
86MP0000604_amyloidosis0.78243286
87MP0003077_abnormal_cell_cycle0.75599589
88MP0003191_abnormal_cellular_cholesterol0.75494756
89MP0001663_abnormal_digestive_system0.73253774
90MP0000249_abnormal_blood_vessel0.71406318
91MP0003111_abnormal_nucleus_morphology0.69448431
92MP0000569_abnormal_digit_pigmentation0.68974787
93MP0002877_abnormal_melanocyte_morpholog0.67962538
94MP0003656_abnormal_erythrocyte_physiolo0.67301904
95MP0005390_skeleton_phenotype0.64426258
96MP0000371_diluted_coat_color0.64419277
97MP0008873_increased_physiological_sensi0.64288818
98MP0006054_spinal_hemorrhage0.63842802
99MP0004130_abnormal_muscle_cell0.60035825
100MP0003638_abnormal_response/metabolism_0.54665508
101MP0004147_increased_porphyrin_level0.53378194
102MP0002693_abnormal_pancreas_physiology0.52693005
103MP0003566_abnormal_cell_adhesion0.52644058
104MP0003795_abnormal_bone_structure0.52587456
105MP0000313_abnormal_cell_death0.52294702
106MP0005451_abnormal_body_composition0.52121115
107MP0002136_abnormal_kidney_physiology0.51729579
108MP0008874_decreased_physiological_sensi0.50748354
109MP0009765_abnormal_xenobiotic_induced0.50085930
110MP0004484_altered_response_of0.49145916
111MP0005084_abnormal_gallbladder_morpholo0.48942441
112MP0004957_abnormal_blastocyst_morpholog0.48901379
113MP0002138_abnormal_hepatobiliary_system0.48009633
114MP0005319_abnormal_enzyme/_coenzyme0.47943813
115MP0005083_abnormal_biliary_tract0.47903410
116MP0004883_abnormal_blood_vessel0.47692915
117MP0000477_abnormal_intestine_morphology0.47434423
118MP0005584_abnormal_enzyme/coenzyme_acti0.46927786
119MP0003252_abnormal_bile_duct0.46532694
120MP0002928_abnormal_bile_duct0.45209529
121MP0005381_digestive/alimentary_phenotyp0.43490275

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.88081829
2Myositis (HP:0100614)5.58186724
3Elevated erythrocyte sedimentation rate (HP:0003565)5.39780582
4Recurrent bacterial skin infections (HP:0005406)4.94607031
5Eczematoid dermatitis (HP:0000976)4.76512088
6Chronic otitis media (HP:0000389)4.58671654
7Orchitis (HP:0100796)4.40467901
8Retrobulbar optic neuritis (HP:0100654)4.31831591
9Optic neuritis (HP:0100653)4.31831591
10IgM deficiency (HP:0002850)4.08277140
11Mediastinal lymphadenopathy (HP:0100721)4.06952532
12Meningitis (HP:0001287)4.04276344
13Recurrent fungal infections (HP:0002841)3.89952307
14Recurrent viral infections (HP:0004429)3.85270144
15Panhypogammaglobulinemia (HP:0003139)3.80371260
16Obstructive lung disease (HP:0006536)3.78657840
17Chronic obstructive pulmonary disease (HP:0006510)3.78657840
18Recurrent gram-negative bacterial infections (HP:0005420)3.69515001
19Abnormality of macrophages (HP:0004311)3.60229674
20Encephalitis (HP:0002383)3.47810928
21Recurrent skin infections (HP:0001581)3.47203939
22Nasal polyposis (HP:0100582)3.42350013
23Thrombocytosis (HP:0001894)3.29573806
24Cellulitis (HP:0100658)3.22983092
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.21036180
26Keratoconjunctivitis sicca (HP:0001097)3.18810952
27Increased IgM level (HP:0003496)3.16439880
28Recurrent cutaneous fungal infections (HP:0011370)3.11839607
29Chronic mucocutaneous candidiasis (HP:0002728)3.11839607
30Recurrent bronchitis (HP:0002837)3.07460943
31Colitis (HP:0002583)3.03301254
32Inflammation of the large intestine (HP:0002037)3.02854141
33Petechiae (HP:0000967)3.01645855
34Vasculitis (HP:0002633)2.98366800
35Abnormality of the prostate (HP:0008775)2.96570066
36Abnormality of the nasal mucosa (HP:0000433)2.95180449
37Reticulocytopenia (HP:0001896)2.93616167
38Agammaglobulinemia (HP:0004432)2.93361246
39Keratoconjunctivitis (HP:0001096)2.92887068
40Fatigue (HP:0012378)2.91905827
41Gastrointestinal inflammation (HP:0004386)2.87693905
42Arterial thrombosis (HP:0004420)2.81719650
43Autoimmune hemolytic anemia (HP:0001890)2.81707298
44Pulmonary infiltrates (HP:0002113)2.79793773
45Thyroiditis (HP:0100646)2.79721458
46Abnormality of T cells (HP:0002843)2.79676394
47Interstitial pulmonary disease (HP:0006530)2.76511504
48T lymphocytopenia (HP:0005403)2.69311573
49Abnormality of T cell physiology (HP:0011840)2.68484754
50Hemoptysis (HP:0002105)2.68038019
51Stomatitis (HP:0010280)2.67269423
52Gingivitis (HP:0000230)2.65895837
53Vacuolated lymphocytes (HP:0001922)2.61586103
54Gastrointestinal infarctions (HP:0005244)2.61520653
55Purpura (HP:0000979)2.55827295
56B lymphocytopenia (HP:0010976)2.54364319
57Abnormality of B cell number (HP:0010975)2.54364319
58Abnormality of T cell number (HP:0011839)2.54078008
59Episodic fever (HP:0001954)2.52986490
60Systemic lupus erythematosus (HP:0002725)2.51483867
61Pustule (HP:0200039)2.50442993
62Hypergammaglobulinemia (HP:0010702)2.49727604
63Leukocytosis (HP:0001974)2.43944690
64Prolonged bleeding time (HP:0003010)2.39830706
65Increased serum ferritin (HP:0003281)2.39100064
66Spontaneous hematomas (HP:0007420)2.38082382
67Papilledema (HP:0001085)2.36410272
68Abnormality of the pleura (HP:0002103)2.34589193
69Viral hepatitis (HP:0006562)2.34496650
70Hypochromic anemia (HP:0001931)2.33179213
71Acute hepatic failure (HP:0006554)2.32466694
72Aplastic anemia (HP:0001915)2.31797483
73Chromsome breakage (HP:0040012)2.30891392
74Abnormal platelet volume (HP:0011876)2.28974105
75Lymphopenia (HP:0001888)2.27791987
76Abnormality of iron homeostasis (HP:0011031)2.27640448
77Severe combined immunodeficiency (HP:0004430)2.27017102
78Epistaxis (HP:0000421)2.25702496
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.25185568
80Lymphoma (HP:0002665)2.24667024
81Amaurosis fugax (HP:0100576)2.22248888
82Increased cerebral lipofuscin (HP:0011813)2.20611506
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.19914777
84Loss of speech (HP:0002371)2.19799397
85Eosinophilia (HP:0001880)2.19369026
86Periodontitis (HP:0000704)2.18956106
87Osteomyelitis (HP:0002754)2.18828408
88Increased IgE level (HP:0003212)2.17398705
89Acute myeloid leukemia (HP:0004808)2.16439668
90Vertigo (HP:0002321)2.16347885
91Hypochromic microcytic anemia (HP:0004840)2.16306852
92Autoimmune thrombocytopenia (HP:0001973)2.16229892
93Combined immunodeficiency (HP:0005387)2.15457932
94Gingival bleeding (HP:0000225)2.15325212
95Chest pain (HP:0100749)2.13450977
96Chronic diarrhea (HP:0002028)2.12903914
97Dysostosis multiplex (HP:0000943)2.11133401
98Pulmonary embolism (HP:0002204)2.11011861
99Granulocytopenia (HP:0001913)2.10082745
100Gangrene (HP:0100758)2.09933384
101Anorexia (HP:0002039)2.08548540
102Urticaria (HP:0001025)2.08256170
103Impaired platelet aggregation (HP:0003540)2.04748783
104Abnormal platelet function (HP:0011869)2.04748783
105Reduced antithrombin III activity (HP:0001976)2.04661557
106IgG deficiency (HP:0004315)2.04496777
107Abnormality of the heme biosynthetic pathway (HP:0010472)2.02337429
108Thrombophlebitis (HP:0004418)2.01712128
109Abnormality of eosinophils (HP:0001879)2.00833453
110Abnormality of transition element cation homeostasis (HP:0011030)2.00076549
111Glomerulopathy (HP:0100820)1.99438524
112Abnormality of DNA repair (HP:0003254)1.99158584
113Sepsis (HP:0100806)1.98855981
114Hypoproteinemia (HP:0003075)1.98269835
115Skin ulcer (HP:0200042)1.98234758
116Hypoplasia of the thymus (HP:0000778)1.97476839
117Amyloidosis (HP:0011034)1.96861957
118Peritonitis (HP:0002586)1.94697758
119Abnormality of the fingertips (HP:0001211)1.94304900
120Chronic sinusitis (HP:0011109)1.93718439
121Papilloma (HP:0012740)1.93440766
122Verrucae (HP:0200043)1.93440766
123Recurrent pneumonia (HP:0006532)1.93190368
124Joint swelling (HP:0001386)1.92710254
125Skin rash (HP:0000988)1.91504629
126Keratitis (HP:0000491)1.90860534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.45720272
2KIT3.80149481
3TXK3.36158101
4FLT33.14161012
5BLK2.99456482
6TAOK32.91377535
7IRAK42.86808755
8TEC2.68418927
9CSF1R2.41741825
10BTK2.30727274
11PRPF4B2.24658027
12TBK12.14980085
13EEF2K2.00325337
14FES2.00097751
15TYK21.98449378
16ITK1.97981057
17SYK1.85386719
18IRAK31.78775494
19STK101.77557491
20ZAP701.76737473
21MAP3K141.70255418
22CLK11.60109028
23SCYL21.58980762
24JAK31.57904020
25MAP2K31.57284151
26RIPK41.57026675
27BMPR21.50898936
28JAK11.40399170
29PIM21.38396798
30CSK1.33303533
31PIM11.31831461
32TGFBR21.31253376
33LCK1.30847649
34GRK61.29785028
35LYN1.28512844
36ERN11.28331277
37ACVR1B1.27506390
38IKBKE1.27032564
39IKBKB1.25792729
40LRRK21.23754971
41HCK1.15165474
42MATK1.09240467
43CCNB11.06329577
44MAP3K11.05755992
45PKN21.03803668
46MST41.03105534
47BRSK21.02046970
48MAP3K30.99198649
49NME20.96957962
50RPS6KA40.96493691
51SIK30.95011725
52TRPM70.93964765
53TESK20.93119872
54VRK10.89781856
55MAP3K120.84756523
56STK160.82741245
57MAPKAPK30.80560144
58TGFBR10.78745548
59NLK0.78147183
60TAOK10.77915446
61MAP3K70.74203712
62EIF2AK30.73688378
63ADRBK20.73372957
64PASK0.73329765
65RPS6KB20.70749483
66PTK2B0.70343024
67GRK70.70155794
68EIF2AK10.69888222
69FYN0.69339609
70EPHB10.68863229
71CDC70.68673960
72BCKDK0.67960014
73MARK20.67077516
74CDK40.66943860
75IRAK10.66704851
76MARK30.65501435
77TNIK0.64601603
78MAPK70.62709883
79EIF2AK20.61673739
80WEE10.60278849
81HIPK20.60272674
82PDPK10.59341676
83MAPK120.57850688
84MAP2K60.57297318
85JAK20.56283441
86MAP3K100.56277879
87CHUK0.55741706
88STK110.55153408
89KDR0.54832261
90CAMKK10.54554906
91PRKD20.52742683
92NEK90.52575040
93CDK190.51923958
94ATR0.47602621
95DYRK1B0.47538821
96MAPK40.47508473
97MAP3K60.46812297
98MAP3K50.46423995
99MAP2K20.46333902
100MAP3K110.44704625
101STK40.44360871
102MAPKAPK20.44067846
103CDK70.43334095
104TAOK20.42154118
105RPS6KA60.41965938
106IRAK20.40352296
107FGR0.40068080
108CDK60.39650682
109KSR20.39154919
110PRKCD0.37369299
111FGFR30.36449780
112YES10.36285549
113MAP3K130.36208729
114TNK20.35955095
115MAP3K80.34992307
116PTK60.34921606
117PIK3CG0.33167304
118BRSK10.33064068
119RPS6KC10.32211646
120RPS6KL10.32211646
121MAPKAPK50.31851006
122PDK10.30243867
123CDK80.29849024
124NEK20.29592867
125TRIB30.29263326
126CAMKK20.28988417
127PRKCQ0.28567291
128NUAK10.28486462
129SIK20.27997571
130ABL10.27479953
131PRKCH0.27071250
132IGF1R0.26993739
133PAK40.26620597
134WNK10.26469566
135MOS0.24692912
136RET0.24310831
137MAPK30.23572386
138GRK50.22573122
139MAPK110.22207795

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.28960550
2Primary immunodeficiency_Homo sapiens_hsa053403.04535474
3Antigen processing and presentation_Homo sapiens_hsa046122.87580787
4Leishmaniasis_Homo sapiens_hsa051402.81013348
5DNA replication_Homo sapiens_hsa030302.74485034
6* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.66907684
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.39317428
8Hematopoietic cell lineage_Homo sapiens_hsa046402.24513666
9Staphylococcus aureus infection_Homo sapiens_hsa051502.16155781
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.12210815
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.11946536
12B cell receptor signaling pathway_Homo sapiens_hsa046622.09443523
13Measles_Homo sapiens_hsa051622.07476646
14Osteoclast differentiation_Homo sapiens_hsa043802.01609263
15Allograft rejection_Homo sapiens_hsa053301.96943195
16Ribosome_Homo sapiens_hsa030101.90750848
17Other glycan degradation_Homo sapiens_hsa005111.90542036
18Pertussis_Homo sapiens_hsa051331.87205353
19Legionellosis_Homo sapiens_hsa051341.79805805
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71390225
21Malaria_Homo sapiens_hsa051441.70554932
22Mismatch repair_Homo sapiens_hsa034301.65063480
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62013375
24Tuberculosis_Homo sapiens_hsa051521.60835259
25Herpes simplex infection_Homo sapiens_hsa051681.59567258
26Base excision repair_Homo sapiens_hsa034101.56874963
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.56774953
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46313685
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.44708275
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.41456944
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41311763
32Shigellosis_Homo sapiens_hsa051311.36072330
33Toxoplasmosis_Homo sapiens_hsa051451.35829110
34Homologous recombination_Homo sapiens_hsa034401.33269167
35Apoptosis_Homo sapiens_hsa042101.31491300
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30519753
37Non-homologous end-joining_Homo sapiens_hsa034501.30512853
38Influenza A_Homo sapiens_hsa051641.30154417
39T cell receptor signaling pathway_Homo sapiens_hsa046601.29672997
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26158232
41Viral myocarditis_Homo sapiens_hsa054161.25308441
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.24152404
43Caffeine metabolism_Homo sapiens_hsa002321.23130589
44Hepatitis B_Homo sapiens_hsa051611.18867122
45Chemokine signaling pathway_Homo sapiens_hsa040621.18700824
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18543891
47Acute myeloid leukemia_Homo sapiens_hsa052211.14743667
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01919965
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01918789
50Platelet activation_Homo sapiens_hsa046111.01176036
51TNF signaling pathway_Homo sapiens_hsa046681.00874057
52Salmonella infection_Homo sapiens_hsa051320.98505610
53Lysosome_Homo sapiens_hsa041420.98224187
54Asthma_Homo sapiens_hsa053100.97363178
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96251761
56Type I diabetes mellitus_Homo sapiens_hsa049400.90870294
57Epstein-Barr virus infection_Homo sapiens_hsa051690.88679385
58p53 signaling pathway_Homo sapiens_hsa041150.83402726
59Autoimmune thyroid disease_Homo sapiens_hsa053200.82140908
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80381669
61Spliceosome_Homo sapiens_hsa030400.79814530
62Nucleotide excision repair_Homo sapiens_hsa034200.79341974
63Chronic myeloid leukemia_Homo sapiens_hsa052200.74700473
64Pentose phosphate pathway_Homo sapiens_hsa000300.74620045
65Renin-angiotensin system_Homo sapiens_hsa046140.73790028
66Pancreatic cancer_Homo sapiens_hsa052120.72883962
67Viral carcinogenesis_Homo sapiens_hsa052030.69099787
68Phagosome_Homo sapiens_hsa041450.68577365
69Cell cycle_Homo sapiens_hsa041100.68510958
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64804895
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64322059
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63734295
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62567445
74Pyrimidine metabolism_Homo sapiens_hsa002400.62404450
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62376718
76Dorso-ventral axis formation_Homo sapiens_hsa043200.61963525
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61803649
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60595995
79HTLV-I infection_Homo sapiens_hsa051660.58382177
80Hepatitis C_Homo sapiens_hsa051600.56511820
81Prolactin signaling pathway_Homo sapiens_hsa049170.55727083
82RNA degradation_Homo sapiens_hsa030180.55401732
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.52729665
84Fanconi anemia pathway_Homo sapiens_hsa034600.52719069
85N-Glycan biosynthesis_Homo sapiens_hsa005100.52161605
86Rheumatoid arthritis_Homo sapiens_hsa053230.52047027
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52028280
88Small cell lung cancer_Homo sapiens_hsa052220.49805768
89Regulation of autophagy_Homo sapiens_hsa041400.48642105
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.48507577
91African trypanosomiasis_Homo sapiens_hsa051430.48457866
92Inositol phosphate metabolism_Homo sapiens_hsa005620.47127897
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46599332
94One carbon pool by folate_Homo sapiens_hsa006700.46358238
95Endocytosis_Homo sapiens_hsa041440.44736896
96mTOR signaling pathway_Homo sapiens_hsa041500.44585900
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.43705148
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43287731
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.42818522
100Choline metabolism in cancer_Homo sapiens_hsa052310.42560024
101Colorectal cancer_Homo sapiens_hsa052100.41684335
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39853461
103Systemic lupus erythematosus_Homo sapiens_hsa053220.38732633
104VEGF signaling pathway_Homo sapiens_hsa043700.38608240
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38243486
106FoxO signaling pathway_Homo sapiens_hsa040680.37474512
107MAPK signaling pathway_Homo sapiens_hsa040100.36905562
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36257075
109Amoebiasis_Homo sapiens_hsa051460.35847828
110Non-small cell lung cancer_Homo sapiens_hsa052230.35619092
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35470522
112Arachidonic acid metabolism_Homo sapiens_hsa005900.35258303
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32766181
114Renal cell carcinoma_Homo sapiens_hsa052110.32438405
115Proteasome_Homo sapiens_hsa030500.31787344
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.31602293
117Insulin resistance_Homo sapiens_hsa049310.30524902
118Complement and coagulation cascades_Homo sapiens_hsa046100.30194311
119Notch signaling pathway_Homo sapiens_hsa043300.28705322
120GnRH signaling pathway_Homo sapiens_hsa049120.27585201
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27480177
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.25784546
123HIF-1 signaling pathway_Homo sapiens_hsa040660.25111686
124MicroRNAs in cancer_Homo sapiens_hsa052060.24452130
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22834078
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22200922
127Type II diabetes mellitus_Homo sapiens_hsa049300.19082513
128Endometrial cancer_Homo sapiens_hsa052130.18208796
129Ras signaling pathway_Homo sapiens_hsa040140.16078745

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