

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 8.29532121 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 7.22673867 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 7.22673867 |
| 4 | sequestering of actin monomers (GO:0042989) | 6.98431948 |
| 5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.71369878 |
| 6 | viral transcription (GO:0019083) | 5.61494283 |
| 7 | respiratory electron transport chain (GO:0022904) | 5.61115513 |
| 8 | chaperone-mediated protein transport (GO:0072321) | 5.54975469 |
| 9 | translational termination (GO:0006415) | 5.53389289 |
| 10 | electron transport chain (GO:0022900) | 5.51018392 |
| 11 | ribosomal small subunit assembly (GO:0000028) | 5.06627604 |
| 12 | protein neddylation (GO:0045116) | 5.04816972 |
| 13 | cotranslational protein targeting to membrane (GO:0006613) | 4.87219823 |
| 14 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.87108365 |
| 15 | neuron fate determination (GO:0048664) | 4.86363595 |
| 16 | protein targeting to ER (GO:0045047) | 4.76119783 |
| 17 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.70165170 |
| 18 | protein complex biogenesis (GO:0070271) | 4.65994158 |
| 19 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.57543725 |
| 20 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.57543725 |
| 21 | NADH dehydrogenase complex assembly (GO:0010257) | 4.57543725 |
| 22 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.55819305 |
| 23 | respiratory chain complex IV assembly (GO:0008535) | 4.53566847 |
| 24 | maturation of SSU-rRNA (GO:0030490) | 4.43904782 |
| 25 | translational elongation (GO:0006414) | 4.43175692 |
| 26 | ribosomal small subunit biogenesis (GO:0042274) | 4.39758900 |
| 27 | protein localization to endoplasmic reticulum (GO:0070972) | 4.39320359 |
| 28 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.33114536 |
| 29 | termination of RNA polymerase III transcription (GO:0006386) | 4.33114536 |
| 30 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.32754213 |
| 31 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.24498249 |
| 32 | cellular protein complex disassembly (GO:0043624) | 4.23845549 |
| 33 | viral life cycle (GO:0019058) | 4.20473494 |
| 34 | cytochrome complex assembly (GO:0017004) | 4.17816866 |
| 35 | translational initiation (GO:0006413) | 4.07238357 |
| 36 | ATP biosynthetic process (GO:0006754) | 4.02429757 |
| 37 | hydrogen ion transmembrane transport (GO:1902600) | 3.98772840 |
| 38 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.95095156 |
| 39 | spermatid nucleus differentiation (GO:0007289) | 3.95031401 |
| 40 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.94351450 |
| 41 | establishment of integrated proviral latency (GO:0075713) | 3.92725973 |
| 42 | behavioral response to nicotine (GO:0035095) | 3.91352307 |
| 43 | protein complex disassembly (GO:0043241) | 3.75058127 |
| 44 | ribosomal large subunit biogenesis (GO:0042273) | 3.63347303 |
| 45 | spliceosomal snRNP assembly (GO:0000387) | 3.59186876 |
| 46 | macromolecular complex disassembly (GO:0032984) | 3.57544005 |
| 47 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.56401957 |
| 48 | CENP-A containing nucleosome assembly (GO:0034080) | 3.53999329 |
| 49 | chromatin remodeling at centromere (GO:0031055) | 3.52900408 |
| 50 | proton transport (GO:0015992) | 3.51883290 |
| 51 | epithelial cilium movement (GO:0003351) | 3.51382630 |
| 52 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.50275610 |
| 53 | hydrogen transport (GO:0006818) | 3.46016176 |
| 54 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.45447135 |
| 55 | regulation of mitochondrial translation (GO:0070129) | 3.42058045 |
| 56 | spliceosomal complex assembly (GO:0000245) | 3.40740465 |
| 57 | translation (GO:0006412) | 3.34905521 |
| 58 | inner mitochondrial membrane organization (GO:0007007) | 3.31750854 |
| 59 | establishment of viral latency (GO:0019043) | 3.30398460 |
| 60 | DNA replication checkpoint (GO:0000076) | 3.28056493 |
| 61 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.24643367 |
| 62 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.23695557 |
| 63 | histone exchange (GO:0043486) | 3.21420197 |
| 64 | rRNA modification (GO:0000154) | 3.20756112 |
| 65 | protein targeting to membrane (GO:0006612) | 3.17131201 |
| 66 | proteasome assembly (GO:0043248) | 3.11915936 |
| 67 | mRNA catabolic process (GO:0006402) | 3.05599991 |
| 68 | base-excision repair, AP site formation (GO:0006285) | 2.99583818 |
| 69 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.96062815 |
| 70 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.96062815 |
| 71 | protein localization to kinetochore (GO:0034501) | 2.92529214 |
| 72 | neuron fate specification (GO:0048665) | 2.91915025 |
| 73 | protein targeting to mitochondrion (GO:0006626) | 2.88275383 |
| 74 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.84548811 |
| 75 | protein localization to mitochondrion (GO:0070585) | 2.84396336 |
| 76 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.84202896 |
| 77 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.82235075 |
| 78 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.82235075 |
| 79 | kinetochore assembly (GO:0051382) | 2.81443895 |
| 80 | purine nucleobase biosynthetic process (GO:0009113) | 2.79381859 |
| 81 | RNA catabolic process (GO:0006401) | 2.79201817 |
| 82 | cellular component biogenesis (GO:0044085) | 2.78418171 |
| 83 | establishment of protein localization to mitochondrion (GO:0072655) | 2.78148757 |
| 84 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.75489640 |
| 85 | regulation of chromatin binding (GO:0035561) | 2.74364243 |
| 86 | mitotic metaphase plate congression (GO:0007080) | 2.74057643 |
| 87 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.72098375 |
| 88 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.71910001 |
| 89 | histone mRNA metabolic process (GO:0008334) | 2.71675476 |
| 90 | DNA replication-independent nucleosome organization (GO:0034724) | 2.71580926 |
| 91 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.71580926 |
| 92 | regulation of helicase activity (GO:0051095) | 2.68917754 |
| 93 | kinetochore organization (GO:0051383) | 2.68559305 |
| 94 | oxidative phosphorylation (GO:0006119) | 2.67928311 |
| 95 | mitochondrial transport (GO:0006839) | 2.67169571 |
| 96 | cilium movement (GO:0003341) | 2.66167757 |
| 97 | platelet dense granule organization (GO:0060155) | 2.64952375 |
| 98 | otic vesicle formation (GO:0030916) | 2.62743925 |
| 99 | intracellular protein transmembrane import (GO:0044743) | 2.61899018 |
| 100 | peptidyl-histidine modification (GO:0018202) | 2.59392414 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.31598061 |
| 2 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.11374376 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.01590917 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.93237360 |
| 5 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 3.37545648 |
| 6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.19029907 |
| 7 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.04271578 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.95880615 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.89780473 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.69670725 |
| 11 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.65143129 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.64086286 |
| 13 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.63521880 |
| 14 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.58987447 |
| 15 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.53975367 |
| 16 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.53474407 |
| 17 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.46846352 |
| 18 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.28627133 |
| 19 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.21146807 |
| 20 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.10488181 |
| 21 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.10300905 |
| 22 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.07621087 |
| 23 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.02344499 |
| 24 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.90456504 |
| 25 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.90387091 |
| 26 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.86364103 |
| 27 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.85764530 |
| 28 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.83620255 |
| 29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.79269871 |
| 30 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.78014632 |
| 31 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.77934419 |
| 32 | FUS_26573619_Chip-Seq_HEK293_Human | 1.77541190 |
| 33 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.77314618 |
| 34 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.74558663 |
| 35 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.72899651 |
| 36 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.68984909 |
| 37 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.58913729 |
| 38 | EWS_26573619_Chip-Seq_HEK293_Human | 1.58806053 |
| 39 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.52375594 |
| 40 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.49832555 |
| 41 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.47758329 |
| 42 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.46590632 |
| 43 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.44876639 |
| 44 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.44386953 |
| 45 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.42962110 |
| 46 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.39075270 |
| 47 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.38449481 |
| 48 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.35566183 |
| 49 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.34435681 |
| 50 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.34353154 |
| 51 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.32705571 |
| 52 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.32475498 |
| 53 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.32347923 |
| 54 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.31433409 |
| 55 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.29778344 |
| 56 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.29778344 |
| 57 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.29778344 |
| 58 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.28115597 |
| 59 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.25774353 |
| 60 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.24192067 |
| 61 | P300_19829295_ChIP-Seq_ESCs_Human | 1.23374653 |
| 62 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.22550611 |
| 63 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.21806459 |
| 64 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.18450094 |
| 65 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.17303182 |
| 66 | VDR_22108803_ChIP-Seq_LS180_Human | 1.17195467 |
| 67 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.17005648 |
| 68 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.13817910 |
| 69 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.12353161 |
| 70 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.11746870 |
| 71 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.06746743 |
| 72 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.05442358 |
| 73 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.03999197 |
| 74 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.02438049 |
| 75 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.02285997 |
| 76 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.01308726 |
| 77 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.00922583 |
| 78 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.99236508 |
| 79 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.93056692 |
| 80 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.92612007 |
| 81 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.92112154 |
| 82 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.91527280 |
| 83 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.88883266 |
| 84 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.88811062 |
| 85 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.82159535 |
| 86 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.81754000 |
| 87 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.80794539 |
| 88 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.80739743 |
| 89 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.79926634 |
| 90 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.79396909 |
| 91 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.78918298 |
| 92 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.78918298 |
| 93 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.78238481 |
| 94 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.78238481 |
| 95 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.77215873 |
| 96 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.76703253 |
| 97 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.75313697 |
| 98 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.74025605 |
| 99 | NCOR_22424771_ChIP-Seq_293T_Human | 0.71382636 |
| 100 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.70926475 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 5.54851758 |
| 2 | MP0000372_irregular_coat_pigmentation | 3.26877149 |
| 3 | MP0003941_abnormal_skin_development | 3.05222046 |
| 4 | MP0010386_abnormal_urinary_bladder | 2.87127226 |
| 5 | MP0002638_abnormal_pupillary_reflex | 2.78269158 |
| 6 | MP0008058_abnormal_DNA_repair | 2.51076883 |
| 7 | MP0006292_abnormal_olfactory_placode | 2.46739042 |
| 8 | MP0003693_abnormal_embryo_hatching | 2.41068472 |
| 9 | MP0001529_abnormal_vocalization | 2.40766577 |
| 10 | MP0002653_abnormal_ependyma_morphology | 2.25160325 |
| 11 | MP0006072_abnormal_retinal_apoptosis | 2.25116232 |
| 12 | MP0004957_abnormal_blastocyst_morpholog | 2.16262283 |
| 13 | MP0005645_abnormal_hypothalamus_physiol | 2.13359848 |
| 14 | MP0001984_abnormal_olfaction | 2.03996727 |
| 15 | MP0004142_abnormal_muscle_tone | 2.03765283 |
| 16 | MP0000566_synostosis | 2.02769320 |
| 17 | MP0003136_yellow_coat_color | 1.87183606 |
| 18 | MP0004133_heterotaxia | 1.77132471 |
| 19 | MP0003077_abnormal_cell_cycle | 1.73013140 |
| 20 | MP0003011_delayed_dark_adaptation | 1.67717781 |
| 21 | MP0006276_abnormal_autonomic_nervous | 1.66037217 |
| 22 | MP0002938_white_spotting | 1.59326484 |
| 23 | MP0008877_abnormal_DNA_methylation | 1.58714817 |
| 24 | MP0003122_maternal_imprinting | 1.53865855 |
| 25 | MP0010094_abnormal_chromosome_stability | 1.52913220 |
| 26 | MP0008789_abnormal_olfactory_epithelium | 1.52259571 |
| 27 | MP0005253_abnormal_eye_physiology | 1.51375106 |
| 28 | MP0002796_impaired_skin_barrier | 1.50383199 |
| 29 | MP0001293_anophthalmia | 1.48538995 |
| 30 | MP0003111_abnormal_nucleus_morphology | 1.48453473 |
| 31 | MP0008995_early_reproductive_senescence | 1.44792283 |
| 32 | MP0001968_abnormal_touch/_nociception | 1.41897125 |
| 33 | MP0003567_abnormal_fetal_cardiomyocyte | 1.39422745 |
| 34 | MP0002736_abnormal_nociception_after | 1.36047014 |
| 35 | MP0008961_abnormal_basal_metabolism | 1.35878856 |
| 36 | MP0002277_abnormal_respiratory_mucosa | 1.29883136 |
| 37 | MP0000631_abnormal_neuroendocrine_gland | 1.27671365 |
| 38 | MP0005377_hearing/vestibular/ear_phenot | 1.26074877 |
| 39 | MP0003878_abnormal_ear_physiology | 1.26074877 |
| 40 | MP0005394_taste/olfaction_phenotype | 1.23358004 |
| 41 | MP0005499_abnormal_olfactory_system | 1.23358004 |
| 42 | MP0008932_abnormal_embryonic_tissue | 1.23101674 |
| 43 | MP0002557_abnormal_social/conspecific_i | 1.19979149 |
| 44 | MP0003938_abnormal_ear_development | 1.18440758 |
| 45 | MP0003186_abnormal_redox_activity | 1.17608164 |
| 46 | MP0002734_abnormal_mechanical_nocicepti | 1.17188544 |
| 47 | MP0000049_abnormal_middle_ear | 1.15312294 |
| 48 | MP0004742_abnormal_vestibular_system | 1.14988629 |
| 49 | MP0003121_genomic_imprinting | 1.14838780 |
| 50 | MP0001485_abnormal_pinna_reflex | 1.14727664 |
| 51 | MP0010030_abnormal_orbit_morphology | 1.13053117 |
| 52 | MP0005551_abnormal_eye_electrophysiolog | 1.12921520 |
| 53 | MP0003119_abnormal_digestive_system | 1.12294144 |
| 54 | MP0001905_abnormal_dopamine_level | 1.11751906 |
| 55 | MP0002254_reproductive_system_inflammat | 1.10592895 |
| 56 | MP0001286_abnormal_eye_development | 1.09643519 |
| 57 | MP0005410_abnormal_fertilization | 1.07287907 |
| 58 | MP0002751_abnormal_autonomic_nervous | 1.03066998 |
| 59 | MP0001486_abnormal_startle_reflex | 1.02468315 |
| 60 | MP0003880_abnormal_central_pattern | 1.02036453 |
| 61 | MP0005084_abnormal_gallbladder_morpholo | 0.99190726 |
| 62 | MP0009046_muscle_twitch | 0.99032149 |
| 63 | MP0000026_abnormal_inner_ear | 0.98948366 |
| 64 | MP0006035_abnormal_mitochondrial_morpho | 0.98543222 |
| 65 | MP0003718_maternal_effect | 0.97437583 |
| 66 | MP0002272_abnormal_nervous_system | 0.94502677 |
| 67 | MP0002210_abnormal_sex_determination | 0.93635810 |
| 68 | MP0003937_abnormal_limbs/digits/tail_de | 0.91505898 |
| 69 | MP0004270_analgesia | 0.91104137 |
| 70 | MP0002837_dystrophic_cardiac_calcinosis | 0.90807811 |
| 71 | MP0001346_abnormal_lacrimal_gland | 0.90260384 |
| 72 | MP0002697_abnormal_eye_size | 0.89856594 |
| 73 | MP0000778_abnormal_nervous_system | 0.88956272 |
| 74 | MP0002234_abnormal_pharynx_morphology | 0.88607856 |
| 75 | MP0003698_abnormal_male_reproductive | 0.88245455 |
| 76 | MP0002572_abnormal_emotion/affect_behav | 0.87216222 |
| 77 | MP0001970_abnormal_pain_threshold | 0.87116440 |
| 78 | MP0001929_abnormal_gametogenesis | 0.86594702 |
| 79 | MP0000579_abnormal_nail_morphology | 0.85459142 |
| 80 | MP0001440_abnormal_grooming_behavior | 0.85194381 |
| 81 | MP0001188_hyperpigmentation | 0.84621378 |
| 82 | MP0003890_abnormal_embryonic-extraembry | 0.84361358 |
| 83 | MP0002752_abnormal_somatic_nervous | 0.84294907 |
| 84 | MP0009745_abnormal_behavioral_response | 0.83963852 |
| 85 | MP0002095_abnormal_skin_pigmentation | 0.83670403 |
| 86 | MP0005195_abnormal_posterior_eye | 0.83456278 |
| 87 | MP0000538_abnormal_urinary_bladder | 0.82449798 |
| 88 | MP0000490_abnormal_crypts_of | 0.81785213 |
| 89 | MP0003315_abnormal_perineum_morphology | 0.78885173 |
| 90 | MP0001177_atelectasis | 0.78505436 |
| 91 | MP0001756_abnormal_urination | 0.78497572 |
| 92 | MP0001764_abnormal_homeostasis | 0.78346588 |
| 93 | MP0005391_vision/eye_phenotype | 0.77122155 |
| 94 | MP0003638_abnormal_response/metabolism_ | 0.76774577 |
| 95 | MP0000653_abnormal_sex_gland | 0.76677245 |
| 96 | MP0005501_abnormal_skin_physiology | 0.76151237 |
| 97 | MP0001502_abnormal_circadian_rhythm | 0.75614625 |
| 98 | MP0003195_calcinosis | 0.74030332 |
| 99 | MP0003787_abnormal_imprinting | 0.74007600 |
| 100 | MP0001145_abnormal_male_reproductive | 0.73986019 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased hepatocellular lipid droplets (HP:0006565) | 5.74047497 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 5.15080830 |
| 3 | Lipid accumulation in hepatocytes (HP:0006561) | 5.08170364 |
| 4 | Mitochondrial inheritance (HP:0001427) | 4.92643874 |
| 5 | Renal Fanconi syndrome (HP:0001994) | 4.72730330 |
| 6 | Acute encephalopathy (HP:0006846) | 4.44509781 |
| 7 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.41602557 |
| 8 | Hepatocellular necrosis (HP:0001404) | 4.41474876 |
| 9 | Progressive macrocephaly (HP:0004481) | 4.34244946 |
| 10 | Increased CSF lactate (HP:0002490) | 4.10423715 |
| 11 | Abnormal number of erythroid precursors (HP:0012131) | 3.94312302 |
| 12 | Hepatic necrosis (HP:0002605) | 3.78354994 |
| 13 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.77417684 |
| 14 | Colon cancer (HP:0003003) | 3.73400262 |
| 15 | Respiratory difficulties (HP:0002880) | 3.71474195 |
| 16 | Abnormality of the labia minora (HP:0012880) | 3.61231494 |
| 17 | Exertional dyspnea (HP:0002875) | 3.55694054 |
| 18 | Reticulocytopenia (HP:0001896) | 3.52701230 |
| 19 | Pendular nystagmus (HP:0012043) | 3.48266610 |
| 20 | Macrocytic anemia (HP:0001972) | 3.46271009 |
| 21 | Oral leukoplakia (HP:0002745) | 3.40052839 |
| 22 | Cerebral edema (HP:0002181) | 3.36549506 |
| 23 | Increased intramyocellular lipid droplets (HP:0012240) | 3.36084755 |
| 24 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.07837442 |
| 25 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.07837442 |
| 26 | Abnormality of renal resorption (HP:0011038) | 3.01982568 |
| 27 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.99881029 |
| 28 | Leukodystrophy (HP:0002415) | 2.90608106 |
| 29 | Esophageal atresia (HP:0002032) | 2.89724093 |
| 30 | Septo-optic dysplasia (HP:0100842) | 2.75391169 |
| 31 | Increased muscle lipid content (HP:0009058) | 2.67227758 |
| 32 | Respiratory failure (HP:0002878) | 2.64940161 |
| 33 | 3-Methylglutaconic aciduria (HP:0003535) | 2.61287782 |
| 34 | Lactic acidosis (HP:0003128) | 2.56999945 |
| 35 | Optic disc pallor (HP:0000543) | 2.53291699 |
| 36 | Pancreatic fibrosis (HP:0100732) | 2.50366741 |
| 37 | Hyperphosphaturia (HP:0003109) | 2.49339332 |
| 38 | Partial duplication of thumb phalanx (HP:0009944) | 2.49153126 |
| 39 | Delayed CNS myelination (HP:0002188) | 2.47249265 |
| 40 | Absent septum pellucidum (HP:0001331) | 2.41644309 |
| 41 | Pancreatic cysts (HP:0001737) | 2.40296221 |
| 42 | Congenital, generalized hypertrichosis (HP:0004540) | 2.37916356 |
| 43 | Exercise intolerance (HP:0003546) | 2.32210513 |
| 44 | Pallor (HP:0000980) | 2.31343954 |
| 45 | True hermaphroditism (HP:0010459) | 2.23301266 |
| 46 | Aplastic anemia (HP:0001915) | 2.18921061 |
| 47 | Abnormality of the septum pellucidum (HP:0007375) | 2.18624511 |
| 48 | Increased serum lactate (HP:0002151) | 2.17788778 |
| 49 | Abnormality of urine glucose concentration (HP:0011016) | 2.16929879 |
| 50 | Glycosuria (HP:0003076) | 2.16929879 |
| 51 | Partial duplication of the phalanx of hand (HP:0009999) | 2.15132296 |
| 52 | Renal tubular dysfunction (HP:0000124) | 2.12757242 |
| 53 | Methylmalonic acidemia (HP:0002912) | 2.12627362 |
| 54 | X-linked dominant inheritance (HP:0001423) | 2.11590805 |
| 55 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.10496652 |
| 56 | Nephronophthisis (HP:0000090) | 2.05621625 |
| 57 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.02480124 |
| 58 | Stenosis of the external auditory canal (HP:0000402) | 2.00278187 |
| 59 | Poor head control (HP:0002421) | 1.98999548 |
| 60 | Abnormality of midbrain morphology (HP:0002418) | 1.98964577 |
| 61 | Molar tooth sign on MRI (HP:0002419) | 1.98964577 |
| 62 | Gastrointestinal atresia (HP:0002589) | 1.98718828 |
| 63 | Birth length less than 3rd percentile (HP:0003561) | 1.98166172 |
| 64 | Thyroid-stimulating hormone excess (HP:0002925) | 1.95579110 |
| 65 | Abnormality of the parietal bone (HP:0002696) | 1.94081493 |
| 66 | Generalized aminoaciduria (HP:0002909) | 1.93562813 |
| 67 | Congenital malformation of the right heart (HP:0011723) | 1.91645066 |
| 68 | Double outlet right ventricle (HP:0001719) | 1.91645066 |
| 69 | Anencephaly (HP:0002323) | 1.91558618 |
| 70 | Cellular immunodeficiency (HP:0005374) | 1.91376225 |
| 71 | Hyperglycinemia (HP:0002154) | 1.87976816 |
| 72 | Rib fusion (HP:0000902) | 1.84083463 |
| 73 | Myokymia (HP:0002411) | 1.82853810 |
| 74 | Nephrogenic diabetes insipidus (HP:0009806) | 1.82336228 |
| 75 | Vaginal atresia (HP:0000148) | 1.81917427 |
| 76 | Lethargy (HP:0001254) | 1.79703561 |
| 77 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.78304389 |
| 78 | Abnormal urine phosphate concentration (HP:0012599) | 1.77990049 |
| 79 | Genital tract atresia (HP:0001827) | 1.77805815 |
| 80 | Hepatoblastoma (HP:0002884) | 1.76770573 |
| 81 | Congenital primary aphakia (HP:0007707) | 1.75652458 |
| 82 | Gait imbalance (HP:0002141) | 1.75390356 |
| 83 | Sclerocornea (HP:0000647) | 1.74953153 |
| 84 | Medial flaring of the eyebrow (HP:0010747) | 1.71048489 |
| 85 | 11 pairs of ribs (HP:0000878) | 1.70935180 |
| 86 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.70159321 |
| 87 | Chronic bronchitis (HP:0004469) | 1.69929264 |
| 88 | Methylmalonic aciduria (HP:0012120) | 1.68192610 |
| 89 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.66188556 |
| 90 | Type 2 muscle fiber atrophy (HP:0003554) | 1.65838646 |
| 91 | Supernumerary spleens (HP:0009799) | 1.64795123 |
| 92 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.61754580 |
| 93 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.61754580 |
| 94 | Abnormal ciliary motility (HP:0012262) | 1.60461129 |
| 95 | Depressed nasal ridge (HP:0000457) | 1.58102733 |
| 96 | Parakeratosis (HP:0001036) | 1.57571810 |
| 97 | Optic nerve hypoplasia (HP:0000609) | 1.57095979 |
| 98 | Bilateral microphthalmos (HP:0007633) | 1.56762785 |
| 99 | Hypomagnesemia (HP:0002917) | 1.54059051 |
| 100 | Amniotic constriction ring (HP:0009775) | 1.53847530 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.37291878 |
| 2 | INSRR | 3.55380301 |
| 3 | CDC7 | 3.27740878 |
| 4 | ZAK | 2.87673678 |
| 5 | WNK3 | 2.86098734 |
| 6 | PBK | 2.83914572 |
| 7 | TNIK | 2.55275457 |
| 8 | NUAK1 | 2.42978662 |
| 9 | BUB1 | 2.40069296 |
| 10 | DYRK3 | 2.39911999 |
| 11 | TAF1 | 2.32510177 |
| 12 | CASK | 2.24242423 |
| 13 | VRK1 | 2.16467028 |
| 14 | DYRK2 | 2.09320700 |
| 15 | NME1 | 2.03976274 |
| 16 | MST4 | 2.00036651 |
| 17 | TLK1 | 1.95616045 |
| 18 | BMPR1B | 1.94652841 |
| 19 | PLK4 | 1.86430109 |
| 20 | PLK3 | 1.79043918 |
| 21 | RPS6KA4 | 1.76118342 |
| 22 | MAP3K4 | 1.76100931 |
| 23 | TRIM28 | 1.73246842 |
| 24 | FGFR2 | 1.68315595 |
| 25 | SRPK1 | 1.63964324 |
| 26 | PNCK | 1.56668783 |
| 27 | TTK | 1.54142865 |
| 28 | NEK1 | 1.53701900 |
| 29 | STK16 | 1.36240999 |
| 30 | CDK8 | 1.33803458 |
| 31 | CAMK1G | 1.30061206 |
| 32 | MKNK2 | 1.29645948 |
| 33 | MKNK1 | 1.26685945 |
| 34 | MUSK | 1.20448413 |
| 35 | STK24 | 1.14468115 |
| 36 | MAP2K7 | 1.11613579 |
| 37 | PLK1 | 1.11032373 |
| 38 | PINK1 | 1.08294605 |
| 39 | AURKB | 1.02845604 |
| 40 | FRK | 1.00624494 |
| 41 | MAP4K2 | 0.97920074 |
| 42 | CHEK2 | 0.96039018 |
| 43 | MINK1 | 0.94653001 |
| 44 | MAP3K9 | 0.90813915 |
| 45 | CAMK1D | 0.88758201 |
| 46 | WNK4 | 0.88002493 |
| 47 | NEK2 | 0.86836990 |
| 48 | ADRBK2 | 0.86806307 |
| 49 | NME2 | 0.86568728 |
| 50 | UHMK1 | 0.86359660 |
| 51 | BRSK2 | 0.83793581 |
| 52 | CSNK1G1 | 0.74022939 |
| 53 | MARK1 | 0.73670387 |
| 54 | PLK2 | 0.72799381 |
| 55 | CDK3 | 0.72158843 |
| 56 | WEE1 | 0.71735744 |
| 57 | BCKDK | 0.70715402 |
| 58 | PRKCG | 0.69231236 |
| 59 | PASK | 0.67866999 |
| 60 | LRRK2 | 0.65466237 |
| 61 | RPS6KA5 | 0.64495448 |
| 62 | CAMK1 | 0.63031771 |
| 63 | PAK4 | 0.62499225 |
| 64 | CSNK2A2 | 0.61453027 |
| 65 | CSNK1E | 0.59575704 |
| 66 | AURKA | 0.58951212 |
| 67 | CSNK2A1 | 0.58668791 |
| 68 | OXSR1 | 0.56612856 |
| 69 | CSNK1G2 | 0.56591175 |
| 70 | TESK1 | 0.56262072 |
| 71 | SGK494 | 0.55275373 |
| 72 | SGK223 | 0.55275373 |
| 73 | PRKD3 | 0.54937303 |
| 74 | CSNK1G3 | 0.53591562 |
| 75 | STK3 | 0.51194122 |
| 76 | TSSK6 | 0.51000982 |
| 77 | PRKG1 | 0.46985762 |
| 78 | GRK1 | 0.46382395 |
| 79 | FGFR1 | 0.46126779 |
| 80 | CDK19 | 0.45008178 |
| 81 | ATR | 0.44438783 |
| 82 | BRSK1 | 0.43771097 |
| 83 | NLK | 0.43599580 |
| 84 | PRKCE | 0.39904354 |
| 85 | TYRO3 | 0.39471545 |
| 86 | SGK2 | 0.35820997 |
| 87 | CDK7 | 0.34431454 |
| 88 | TGFBR1 | 0.33433374 |
| 89 | CHEK1 | 0.32813335 |
| 90 | STK4 | 0.32416911 |
| 91 | CSNK1A1 | 0.32307270 |
| 92 | ATM | 0.31277571 |
| 93 | BCR | 0.30734277 |
| 94 | STK11 | 0.30605050 |
| 95 | PRKDC | 0.30103082 |
| 96 | PAK3 | 0.29588460 |
| 97 | CAMK2G | 0.27327381 |
| 98 | CDK1 | 0.26971318 |
| 99 | DAPK3 | 0.26415935 |
| 100 | CSNK1A1L | 0.26132702 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.37385228 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.89460278 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.31614291 |
| 4 | Huntingtons disease_Homo sapiens_hsa05016 | 3.36532257 |
| 5 | Proteasome_Homo sapiens_hsa03050 | 3.16976566 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.05228504 |
| 7 | Alzheimers disease_Homo sapiens_hsa05010 | 3.00372270 |
| 8 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.63758553 |
| 9 | Protein export_Homo sapiens_hsa03060 | 2.52984368 |
| 10 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.47163751 |
| 11 | DNA replication_Homo sapiens_hsa03030 | 2.30791828 |
| 12 | Mismatch repair_Homo sapiens_hsa03430 | 2.19577395 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 2.12646798 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 1.94661779 |
| 15 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.93699678 |
| 16 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.84298749 |
| 17 | Base excision repair_Homo sapiens_hsa03410 | 1.80921013 |
| 18 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.74777179 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.61553135 |
| 20 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.48513115 |
| 21 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.47276446 |
| 22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.44091124 |
| 23 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.41282984 |
| 24 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.37135192 |
| 25 | RNA transport_Homo sapiens_hsa03013 | 1.34832146 |
| 26 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.33520993 |
| 27 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.29843689 |
| 28 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.28277979 |
| 29 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.25486877 |
| 30 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.16446878 |
| 31 | Purine metabolism_Homo sapiens_hsa00230 | 1.15916248 |
| 32 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.14535109 |
| 33 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.11203757 |
| 34 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.07531439 |
| 35 | Cell cycle_Homo sapiens_hsa04110 | 1.04868100 |
| 36 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.01445585 |
| 37 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.99397627 |
| 38 | Phototransduction_Homo sapiens_hsa04744 | 0.97915691 |
| 39 | Nicotine addiction_Homo sapiens_hsa05033 | 0.95732136 |
| 40 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.90857787 |
| 41 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.85489222 |
| 42 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.83969063 |
| 43 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.83737704 |
| 44 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.78759511 |
| 45 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.78504326 |
| 46 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.77921190 |
| 47 | Metabolic pathways_Homo sapiens_hsa01100 | 0.75022953 |
| 48 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.72994021 |
| 49 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.67559309 |
| 50 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.63826159 |
| 51 | Sulfur relay system_Homo sapiens_hsa04122 | 0.63820681 |
| 52 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.61354412 |
| 53 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.58200672 |
| 54 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.57152507 |
| 55 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.55276665 |
| 56 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.55122924 |
| 57 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.54925874 |
| 58 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.52328110 |
| 59 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.51183698 |
| 60 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.50946675 |
| 61 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.50646465 |
| 62 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.49330637 |
| 63 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.49286897 |
| 64 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.48584268 |
| 65 | Olfactory transduction_Homo sapiens_hsa04740 | 0.48087082 |
| 66 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.41936448 |
| 67 | Taste transduction_Homo sapiens_hsa04742 | 0.41894570 |
| 68 | Retinol metabolism_Homo sapiens_hsa00830 | 0.41415679 |
| 69 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.40618603 |
| 70 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.38110936 |
| 71 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.37168579 |
| 72 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.36744828 |
| 73 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.36089061 |
| 74 | Circadian rhythm_Homo sapiens_hsa04710 | 0.35116478 |
| 75 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.33467716 |
| 76 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.31241821 |
| 77 | Peroxisome_Homo sapiens_hsa04146 | 0.31098142 |
| 78 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.30722034 |
| 79 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.30239614 |
| 80 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.30063323 |
| 81 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.29847810 |
| 82 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.29262400 |
| 83 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.29035844 |
| 84 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.26378675 |
| 85 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.26033711 |
| 86 | Carbon metabolism_Homo sapiens_hsa01200 | 0.25770182 |
| 87 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.25746323 |
| 88 | Tight junction_Homo sapiens_hsa04530 | 0.23633629 |
| 89 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.23318379 |
| 90 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.22158155 |
| 91 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.21913559 |
| 92 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.21857898 |
| 93 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.21257908 |
| 94 | Alcoholism_Homo sapiens_hsa05034 | 0.19166999 |
| 95 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.18310106 |
| 96 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.15866605 |
| 97 | GABAergic synapse_Homo sapiens_hsa04727 | 0.14391489 |
| 98 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.13387096 |
| 99 | Morphine addiction_Homo sapiens_hsa05032 | 0.13254531 |
| 100 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.13131153 |

