CD27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)7.88917401
2cytidine metabolic process (GO:0046087)7.88917401
3cytidine catabolic process (GO:0006216)7.88917401
4pyrimidine ribonucleoside catabolic process (GO:0046133)7.13979862
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.78219650
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.73614004
7antigen processing and presentation via MHC class Ib (GO:0002475)6.51101295
8ribosomal small subunit assembly (GO:0000028)6.33279454
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.00070559
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.00070559
11DNA deamination (GO:0045006)5.84631567
12T cell migration (GO:0072678)5.83423421
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.44336173
14negative regulation of cell killing (GO:0031342)5.44336173
15positive thymic T cell selection (GO:0045059)5.35103169
16cellular response to interleukin-15 (GO:0071350)5.34172336
17positive T cell selection (GO:0043368)5.32412249
18thymic T cell selection (GO:0045061)5.21434734
19viral transcription (GO:0019083)5.02011390
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.99749756
21antigen processing and presentation of endogenous antigen (GO:0019883)4.93257539
22regulation of T cell tolerance induction (GO:0002664)4.87484654
23translational termination (GO:0006415)4.81409678
24T cell selection (GO:0045058)4.78800198
25positive regulation of gamma-delta T cell activation (GO:0046645)4.63968191
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.59826285
27regulation of natural killer cell mediated immunity (GO:0002715)4.55186565
28regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.55186565
29positive regulation of natural killer cell mediated immunity (GO:0002717)4.39346457
30positive regulation of tolerance induction (GO:0002645)4.36804322
31B cell receptor signaling pathway (GO:0050853)4.30770359
32T cell receptor signaling pathway (GO:0050852)4.29330073
33regulation of alpha-beta T cell proliferation (GO:0046640)4.28001911
34response to interferon-beta (GO:0035456)4.25149945
35T cell costimulation (GO:0031295)4.25072612
36positive regulation of T cell mediated cytotoxicity (GO:0001916)4.24907166
37translational elongation (GO:0006414)4.24738006
38lymphocyte costimulation (GO:0031294)4.23034938
39regulation of isotype switching to IgG isotypes (GO:0048302)4.20637958
40negative regulation of erythrocyte differentiation (GO:0045647)4.17537624
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.13880821
42antigen receptor-mediated signaling pathway (GO:0050851)4.13358159
43regulation of interleukin-2 biosynthetic process (GO:0045076)4.12602381
44platelet dense granule organization (GO:0060155)4.10749999
45ribosomal small subunit biogenesis (GO:0042274)4.10315875
46positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.06898994
47maturation of SSU-rRNA (GO:0030490)4.05043731
48regulation of T cell mediated cytotoxicity (GO:0001914)4.04714957
49cotranslational protein targeting to membrane (GO:0006613)4.04169248
50positive regulation of alpha-beta T cell proliferation (GO:0046641)4.03966800
51regulation of tolerance induction (GO:0002643)4.03582238
52protein targeting to ER (GO:0045047)4.00755333
53leukocyte aggregation (GO:0070486)3.91687534
54actin nucleation (GO:0045010)3.91147361
55lymphoid progenitor cell differentiation (GO:0002320)3.91142277
56negative regulation of viral genome replication (GO:0045071)3.89953807
57protein localization to endoplasmic reticulum (GO:0070972)3.83446149
58establishment of protein localization to endoplasmic reticulum (GO:0072599)3.81371586
59defense response to protozoan (GO:0042832)3.77582830
60positive regulation of cell killing (GO:0031343)3.74781075
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.74578455
62positive regulation of calcium-mediated signaling (GO:0050850)3.73492248
63mast cell activation (GO:0045576)3.72878528
64regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.69542998
65viral life cycle (GO:0019058)3.68466483
66regulation of gamma-delta T cell differentiation (GO:0045586)3.67642843
67lymphocyte chemotaxis (GO:0048247)3.66752531
68positive regulation of interleukin-4 production (GO:0032753)3.66132519
69pyrimidine nucleoside catabolic process (GO:0046135)3.64804284
70lymphocyte migration (GO:0072676)3.63170121
71L-fucose catabolic process (GO:0042355)3.62905962
72fucose catabolic process (GO:0019317)3.62905962
73L-fucose metabolic process (GO:0042354)3.62905962
74cellular response to interferon-beta (GO:0035458)3.58278280
75regulation of cell killing (GO:0031341)3.58266337
76response to protozoan (GO:0001562)3.57981323
77cellular protein complex disassembly (GO:0043624)3.56613389
78tolerance induction (GO:0002507)3.52894991
79activated T cell proliferation (GO:0050798)3.50812499
80T cell homeostasis (GO:0043029)3.47280373
81regulation of defense response to virus by virus (GO:0050690)3.45118147
82regulation of chronic inflammatory response (GO:0002676)3.43470209
83endosome to pigment granule transport (GO:0043485)3.43039587
84endosome to melanosome transport (GO:0035646)3.43039587
85definitive hemopoiesis (GO:0060216)3.42636193
86telomere maintenance via semi-conservative replication (GO:0032201)3.38176614
87translational initiation (GO:0006413)3.31254808
88negative regulation of lymphocyte mediated immunity (GO:0002707)3.30894955
89regulation of gamma-delta T cell activation (GO:0046643)3.29934793
90positive regulation of interleukin-2 production (GO:0032743)3.29842281
91regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.28817790
92regulation of lymphocyte chemotaxis (GO:1901623)3.28050174
93cytolysis (GO:0019835)3.28041335
94positive regulation of humoral immune response (GO:0002922)3.26798440
95negative regulation of leukocyte mediated immunity (GO:0002704)3.23769122
96negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.21713121
97regulation of interleukin-4 production (GO:0032673)3.20632941
98mature B cell differentiation involved in immune response (GO:0002313)3.20452505
99positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19904288
100negative regulation of T cell mediated immunity (GO:0002710)3.18324988
101protein complex disassembly (GO:0043241)3.18300583
102regulation of T cell receptor signaling pathway (GO:0050856)3.16090162
103dendritic cell chemotaxis (GO:0002407)3.15987979
104positive regulation of lymphocyte migration (GO:2000403)3.15722040
105interferon-gamma production (GO:0032609)3.15496161
106positive regulation of T cell chemotaxis (GO:0010820)3.14575570
107regulation of T cell chemotaxis (GO:0010819)3.14575570
108respiratory burst (GO:0045730)3.13815681
109lymph node development (GO:0048535)3.13189609
110regulation of activation of Janus kinase activity (GO:0010533)3.12389996
111regulation of B cell receptor signaling pathway (GO:0050855)3.12244385
112positive regulation of interleukin-8 secretion (GO:2000484)3.11730455
113megakaryocyte development (GO:0035855)3.10199605
114DNA strand elongation involved in DNA replication (GO:0006271)3.09944413
115chemokine-mediated signaling pathway (GO:0070098)3.08846166
116positive regulation of granulocyte differentiation (GO:0030854)3.07732272
117positive regulation of lymphocyte mediated immunity (GO:0002708)3.07314503
118pseudouridine synthesis (GO:0001522)3.07306271
119mast cell activation involved in immune response (GO:0002279)3.07265419
120mast cell degranulation (GO:0043303)3.07265419
121DNA strand elongation (GO:0022616)3.06444588
122immune response-activating cell surface receptor signaling pathway (GO:0002429)3.05128680
123cellular defense response (GO:0006968)3.04126738
124secretory granule organization (GO:0033363)3.03245161
125regulation of alpha-beta T cell activation (GO:0046634)3.00105001
126positive regulation of T cell mediated immunity (GO:0002711)2.99522927
127* regulation of B cell differentiation (GO:0045577)2.98588031
128macromolecular complex disassembly (GO:0032984)2.98130825
129lipopolysaccharide biosynthetic process (GO:0009103)2.96363854
130nuclear-transcribed mRNA catabolic process (GO:0000956)2.94708807
131regulation of viral genome replication (GO:0045069)2.93173192
132response to interferon-alpha (GO:0035455)2.88956828
133regulation of regulatory T cell differentiation (GO:0045589)2.87646250
134mRNA catabolic process (GO:0006402)2.83376733
135regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.82210756
136cellular response to type I interferon (GO:0071357)2.81470729
137type I interferon signaling pathway (GO:0060337)2.81470729
138ribosomal large subunit biogenesis (GO:0042273)2.80645003
139deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80339298
140telomere maintenance via recombination (GO:0000722)2.79387859
141* positive regulation of B cell differentiation (GO:0045579)2.79290338
142positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.79197595
143regulation of natural killer cell activation (GO:0032814)2.78849434
144response to type I interferon (GO:0034340)2.78839948
145leukocyte homeostasis (GO:0001776)2.78621162
146response to interleukin-15 (GO:0070672)2.77405857
147myeloid dendritic cell activation (GO:0001773)2.73551822
148negative T cell selection (GO:0043383)2.72399300
149regulation of necroptotic process (GO:0060544)2.71208005
150respiratory chain complex IV assembly (GO:0008535)2.70509943
151positive regulation of defense response to virus by host (GO:0002230)2.69798130
152Arp2/3 complex-mediated actin nucleation (GO:0034314)2.68709566
153tRNA methylation (GO:0030488)2.68370380
154RNA catabolic process (GO:0006401)2.68306987
155positive regulation of natural killer cell activation (GO:0032816)2.66844583
156positive regulation of macrophage differentiation (GO:0045651)2.65934017
157protein targeting to membrane (GO:0006612)2.65230892
158regulation of response to tumor cell (GO:0002834)2.64939464
159positive regulation of response to tumor cell (GO:0002836)2.64939464
160positive regulation of immune response to tumor cell (GO:0002839)2.64939464
161regulation of immune response to tumor cell (GO:0002837)2.64939464
162lymphocyte homeostasis (GO:0002260)2.64833526
163regulation of leukocyte mediated cytotoxicity (GO:0001910)2.63817339
164ribonucleoprotein complex biogenesis (GO:0022613)2.62244154
165chaperone mediated protein folding requiring cofactor (GO:0051085)2.61792308
166mature B cell differentiation (GO:0002335)2.61042783
167negative thymic T cell selection (GO:0045060)2.59090590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.31307746
2SCL_19346495_ChIP-Seq_HPC-7_Human3.50420167
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.37455389
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32294147
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.25342264
6SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.07365648
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.05915833
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00036674
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.98519163
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.84499724
11* NOTCH1_21737748_ChIP-Seq_TLL_Human2.77403504
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.75647837
13FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.74398656
14TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.67513663
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67164658
16MYC_22102868_ChIP-Seq_BL_Human2.65338713
17VDR_21846776_ChIP-Seq_THP-1_Human2.50898128
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45923462
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30918542
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.28284887
21ERG_20887958_ChIP-Seq_HPC-7_Mouse2.20301708
22SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.16355677
23SPI1_23547873_ChIP-Seq_NB4_Human2.16008983
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.14275557
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13071172
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13023508
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09735870
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09218541
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.08036994
30VDR_23849224_ChIP-Seq_CD4+_Human2.07156104
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06956244
32CIITA_25753668_ChIP-Seq_RAJI_Human2.05907506
33EST1_17652178_ChIP-ChIP_JURKAT_Human2.05322107
34MYB_26560356_Chip-Seq_TH2_Human2.03231595
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99669041
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.97425526
37MAF_26560356_Chip-Seq_TH1_Human1.94371597
38FOXP3_21729870_ChIP-Seq_TREG_Human1.90552897
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.87980859
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87580502
41GATA3_26560356_Chip-Seq_TH2_Human1.87570954
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85922205
43GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.82083631
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81195352
45VDR_24763502_ChIP-Seq_THP-1_Human1.79793531
46* MYB_26560356_Chip-Seq_TH1_Human1.79480508
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.77632507
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.76699954
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74740347
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73465666
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72563325
52UTX_26944678_Chip-Seq_JUKART_Human1.72528801
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71300566
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.71262516
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70710401
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69977913
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64206296
58RUNX_20019798_ChIP-Seq_JUKART_Human1.59565852
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57612332
60XRN2_22483619_ChIP-Seq_HELA_Human1.56514273
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.56379324
62GATA1_22025678_ChIP-Seq_K562_Human1.54699820
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48323030
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44965069
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44605735
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.43914944
67GABP_19822575_ChIP-Seq_HepG2_Human1.43841768
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41659137
69* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39836148
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37101258
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36549582
72TCF7_22412390_ChIP-Seq_EML_Mouse1.35805516
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35772912
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34945016
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34802148
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33881275
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32875370
78MAF_26560356_Chip-Seq_TH2_Human1.31115958
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30330308
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29638122
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25774555
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.25697122
83* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24242791
84DCP1A_22483619_ChIP-Seq_HELA_Human1.18316879
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18194422
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16758404
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16624404
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16500397
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15889796
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.13469413
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12769525
92TTF2_22483619_ChIP-Seq_HELA_Human1.12299906
93THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11263073
94GATA3_27048872_Chip-Seq_THYMUS_Human1.10359319
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07156783
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06465785
97SPI1_23127762_ChIP-Seq_K562_Human1.06360268
98* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06194002
99* BCOR_27268052_Chip-Seq_Bcells_Human1.06147057
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04827931
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04512309
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03209804
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.03011063
104E2F1_21310950_ChIP-Seq_MCF-7_Human1.01699007
105P300_27268052_Chip-Seq_Bcells_Human1.00518483
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99441880
107TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98790809
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98753605
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96557129
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96209122
111CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96085683
112ELF1_20517297_ChIP-Seq_JURKAT_Human0.95959215
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95137423
114ELK1_19687146_ChIP-ChIP_HELA_Human0.94888473
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.94755725
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93625673
117PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91787844
118VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91500856
119CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91134203
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90994313
121ETS1_22383799_ChIP-Seq_G1ME_Mouse0.90734086
122* BCL6_27268052_Chip-Seq_Bcells_Human0.88719758
123RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85096370
124GATA3_26560356_Chip-Seq_TH1_Human0.83481184
125IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82353650
126KDM2B_26808549_Chip-Seq_DND41_Human0.80544473
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80416699
128PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80273352
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79476806
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77374656
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76790458
132SA1_27219007_Chip-Seq_Bcells_Human0.76611533
133SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75717918
134SPI1_20517297_ChIP-Seq_HL60_Human0.75699884
135VDR_24787735_ChIP-Seq_THP-1_Human0.72846248
136YY1_22570637_ChIP-Seq_MALME-3M_Human0.72818938
137CTCF_20526341_ChIP-Seq_ESCs_Human0.72490030
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.72252691
139LXR_22292898_ChIP-Seq_THP-1_Human0.71722686
140CTCF_26484167_Chip-Seq_Bcells_Mouse0.70926758
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.70043631
142NANOG_20526341_ChIP-Seq_ESCs_Human0.69842846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.29509406
2MP0005671_abnormal_response_to3.88075307
3MP0003763_abnormal_thymus_physiology3.73725165
4MP0005075_abnormal_melanosome_morpholog3.66759886
5MP0001835_abnormal_antigen_presentation3.63738790
6MP0000685_abnormal_immune_system3.54323946
7MP0009785_altered_susceptibility_to3.24621747
8MP0005174_abnormal_tail_pigmentation2.81042182
9MP0002398_abnormal_bone_marrow2.57223704
10MP0002166_altered_tumor_susceptibility2.56293730
11MP0001986_abnormal_taste_sensitivity2.53386542
12MP0005025_abnormal_response_to2.50472558
13MP0001800_abnormal_humoral_immune2.49734401
14MP0004808_abnormal_hematopoietic_stem2.44415879
15MP0005464_abnormal_platelet_physiology2.44261844
16* MP0002420_abnormal_adaptive_immunity2.40715821
17MP0001819_abnormal_immune_cell2.37973519
18MP0002723_abnormal_immune_serum2.36745264
19MP0001545_abnormal_hematopoietic_system2.29416061
20MP0005397_hematopoietic_system_phenotyp2.29416061
21MP0003436_decreased_susceptibility_to2.25345164
22MP0005000_abnormal_immune_tolerance2.25022530
23MP0002452_abnormal_antigen_presenting2.23871087
24* MP0000716_abnormal_immune_system2.16552763
25MP0003724_increased_susceptibility_to2.15654163
26MP0000689_abnormal_spleen_morphology2.14614002
27MP0002722_abnormal_immune_system2.13557379
28MP0003866_abnormal_defecation2.08857062
29MP0002148_abnormal_hypersensitivity_rea2.08386028
30MP0009333_abnormal_splenocyte_physiolog2.07197116
31MP0002006_tumorigenesis2.04633739
32MP0001873_stomach_inflammation2.02401088
33MP0001790_abnormal_immune_system2.00376722
34MP0005387_immune_system_phenotype2.00376722
35MP0000703_abnormal_thymus_morphology1.96027789
36MP0000015_abnormal_ear_pigmentation1.95081432
37* MP0002429_abnormal_blood_cell1.94670532
38MP0002095_abnormal_skin_pigmentation1.94028599
39MP0000490_abnormal_crypts_of1.92940189
40MP0002419_abnormal_innate_immunity1.88960708
41MP0003045_fibrosis1.87744299
42MP0000465_gastrointestinal_hemorrhage1.87300691
43MP0010155_abnormal_intestine_physiology1.85129720
44MP0002405_respiratory_system_inflammati1.80626685
45MP0008007_abnormal_cellular_replicative1.75659060
46MP0003172_abnormal_lysosome_physiology1.73587803
47MP0003693_abnormal_embryo_hatching1.65197809
48MP0001853_heart_inflammation1.63551295
49MP0003448_altered_tumor_morphology1.47719376
50MP0002277_abnormal_respiratory_mucosa1.45234448
51MP0010094_abnormal_chromosome_stability1.43528242
52MP0000372_irregular_coat_pigmentation1.38975132
53MP0001845_abnormal_inflammatory_respons1.38396071
54MP0002138_abnormal_hepatobiliary_system1.35822310
55MP0008058_abnormal_DNA_repair1.33500646
56MP0009379_abnormal_foot_pigmentation1.32231382
57MP0008057_abnormal_DNA_replication1.29797056
58MP0002933_joint_inflammation1.27375721
59MP0008469_abnormal_protein_level1.26906345
60MP0002019_abnormal_tumor_incidence1.26654400
61MP0003077_abnormal_cell_cycle1.24702036
62MP0002132_abnormal_respiratory_system1.18098561
63MP0004147_increased_porphyrin_level1.15241582
64MP0004947_skin_inflammation1.13836049
65MP0003191_abnormal_cellular_cholesterol1.12319584
66MP0000858_altered_metastatic_potential1.11871257
67MP0004957_abnormal_blastocyst_morpholog1.04533032
68MP0005645_abnormal_hypothalamus_physiol1.01742510
69MP0005166_decreased_susceptibility_to1.01186998
70MP0006082_CNS_inflammation1.00743432
71MP0000371_diluted_coat_color0.96159515
72MP0006036_abnormal_mitochondrial_physio0.93858410
73MP0003300_gastrointestinal_ulcer0.93692128
74MP0000313_abnormal_cell_death0.90317680
75MP0005409_darkened_coat_color0.87963828
76MP0001348_abnormal_lacrimal_gland0.87401100
77MP0002693_abnormal_pancreas_physiology0.85732869
78MP0006054_spinal_hemorrhage0.85233819
79MP0003656_abnormal_erythrocyte_physiolo0.83015003
80MP0003111_abnormal_nucleus_morphology0.81872400
81MP0002075_abnormal_coat/hair_pigmentati0.81632063
82MP0001533_abnormal_skeleton_physiology0.81508554
83MP0006292_abnormal_olfactory_placode0.80290160
84MP0003183_abnormal_peptide_metabolism0.78647250
85MP0009765_abnormal_xenobiotic_induced0.75588823
86MP0002009_preneoplasia0.74653807
87MP0003943_abnormal_hepatobiliary_system0.74273057
88MP0000604_amyloidosis0.73776774
89MP0004145_abnormal_muscle_electrophysio0.73265474
90MP0004381_abnormal_hair_follicle0.72626704
91MP0001188_hyperpigmentation0.72515929
92MP0003075_altered_response_to0.71369880
93MP0000477_abnormal_intestine_morphology0.71185029
94MP0002163_abnormal_gland_morphology0.70047648
95MP0009763_increased_sensitivity_to0.69694324
96MP0002998_abnormal_bone_remodeling0.69295722
97MP0001663_abnormal_digestive_system0.69175557
98MP0001851_eye_inflammation0.66919019
99MP0009278_abnormal_bone_marrow0.63682872
100MP0001919_abnormal_reproductive_system0.63375766
101MP0002136_abnormal_kidney_physiology0.61674905
102MP0005310_abnormal_salivary_gland0.60760505
103MP0003786_premature_aging0.60197095
104MP0005423_abnormal_somatic_nervous0.60102917
105MP0009764_decreased_sensitivity_to0.57105724
106MP0008873_increased_physiological_sensi0.56021458
107MP0001186_pigmentation_phenotype0.54279725
108MP0000681_abnormal_thyroid_gland0.53992058
109MP0005584_abnormal_enzyme/coenzyme_acti0.53382462
110MP0003878_abnormal_ear_physiology0.53037683
111MP0005377_hearing/vestibular/ear_phenot0.53037683
112MP0004510_myositis0.52480763
113MP0003567_abnormal_fetal_cardiomyocyte0.51273106
114MP0000358_abnormal_cell_content/0.50395203
115MP0000249_abnormal_blood_vessel0.49819117
116MP0009643_abnormal_urine_homeostasis0.48329411
117MP0000350_abnormal_cell_proliferation0.48051976
118MP0001765_abnormal_ion_homeostasis0.47213623
119MP0000598_abnormal_liver_morphology0.47080573
120MP0004883_abnormal_blood_vessel0.46802506
121MP0000343_altered_response_to0.46572199
122MP0003303_peritoneal_inflammation0.45157238
123MP0003646_muscle_fatigue0.44679563
124MP0003186_abnormal_redox_activity0.44584042
125MP0003795_abnormal_bone_structure0.44381326
126MP0005058_abnormal_lysosome_morphology0.44072871
127MP0001542_abnormal_bone_strength0.43630847
128MP0005390_skeleton_phenotype0.43220692
129MP0008872_abnormal_physiological_respon0.42342050
130MP0002653_abnormal_ependyma_morphology0.42146689
131MP0003828_pulmonary_edema0.42092672
132MP0009642_abnormal_blood_homeostasis0.40902847
133MP0002102_abnormal_ear_morphology0.40693418
134MP0008874_decreased_physiological_sensi0.40456923
135MP0005381_digestive/alimentary_phenotyp0.40071079
136MP0002168_other_aberrant_phenotype0.39284747
137MP0003252_abnormal_bile_duct0.38905118
138MP0008961_abnormal_basal_metabolism0.38843527
139MP0002083_premature_death0.38614801

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.18835795
2Thrombocytosis (HP:0001894)5.76715694
3Chronic otitis media (HP:0000389)5.12702711
4IgM deficiency (HP:0002850)4.88175825
5Myositis (HP:0100614)4.84006086
6Abnormality of B cell number (HP:0010975)4.38182798
7B lymphocytopenia (HP:0010976)4.38182798
8Increased IgM level (HP:0003496)4.24306418
9Abnormality of cells of the erythroid lineage (HP:0012130)4.14898841
10Abnormal number of erythroid precursors (HP:0012131)4.13903596
11Panhypogammaglobulinemia (HP:0003139)4.11339322
12Recurrent bronchitis (HP:0002837)4.04418329
13Chronic obstructive pulmonary disease (HP:0006510)3.63442831
14Obstructive lung disease (HP:0006536)3.63442831
15IgG deficiency (HP:0004315)3.52257807
16Abnormality of T cells (HP:0002843)3.46030133
17Reticulocytopenia (HP:0001896)3.35066619
18Nasal polyposis (HP:0100582)3.34515319
19Abnormality of T cell physiology (HP:0011840)3.34308493
20Abnormality of the nasal mucosa (HP:0000433)3.32214805
21Eosinophilia (HP:0001880)3.26282769
22Petechiae (HP:0000967)3.23544267
23Type 2 muscle fiber atrophy (HP:0003554)3.19404968
24Retrobulbar optic neuritis (HP:0100654)3.19300182
25Optic neuritis (HP:0100653)3.19300182
26Pulmonary infiltrates (HP:0002113)3.17822597
27Broad face (HP:0000283)3.15112101
28Muscle fiber atrophy (HP:0100295)3.13973216
29Severe combined immunodeficiency (HP:0004430)3.13720218
30Gastrointestinal inflammation (HP:0004386)3.11891203
31Prolonged bleeding time (HP:0003010)3.08768289
32Hypoproteinemia (HP:0003075)3.08061234
33Gastrointestinal infarctions (HP:0005244)3.07539927
34Inflammation of the large intestine (HP:0002037)3.03962941
35T lymphocytopenia (HP:0005403)3.03757652
36Recurrent abscess formation (HP:0002722)3.02816906
37Orchitis (HP:0100796)3.01201471
38Recurrent viral infections (HP:0004429)3.00838917
39Hypoplasia of the thymus (HP:0000778)3.00559900
40Type I transferrin isoform profile (HP:0003642)3.00356538
41* Abnormality of macrophages (HP:0004311)2.92046908
42Epistaxis (HP:0000421)2.90391121
43Joint swelling (HP:0001386)2.86428695
44Abnormality of T cell number (HP:0011839)2.83997262
45Poikiloderma (HP:0001029)2.83345363
46Increased IgE level (HP:0003212)2.82877971
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.82559761
48Colon cancer (HP:0003003)2.82294869
49Acute lymphatic leukemia (HP:0006721)2.78436188
50Autoimmune thrombocytopenia (HP:0001973)2.76929815
51Albinism (HP:0001022)2.75703430
52* Aplastic anemia (HP:0001915)2.75479366
53Interstitial pulmonary disease (HP:0006530)2.74529010
54Abnormality of the columella (HP:0009929)2.72436863
55Recurrent fungal infections (HP:0002841)2.69831200
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.67737709
57Abnormality of the heme biosynthetic pathway (HP:0010472)2.66766142
58Lymphopenia (HP:0001888)2.66516792
59Severe visual impairment (HP:0001141)2.65967500
60Amaurosis fugax (HP:0100576)2.64881593
61IgA deficiency (HP:0002720)2.64510453
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.63407710
63Abnormal protein N-linked glycosylation (HP:0012347)2.63407710
64Abnormal protein glycosylation (HP:0012346)2.63407710
65Abnormal glycosylation (HP:0012345)2.63407710
66Thyroiditis (HP:0100646)2.62547135
67Combined immunodeficiency (HP:0005387)2.62183364
68Hemoptysis (HP:0002105)2.61052121
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58444160
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58444160
71Recurrent otitis media (HP:0000403)2.55850115
72Pallor (HP:0000980)2.55195522
73Macrocytic anemia (HP:0001972)2.50544679
74Recurrent bacterial skin infections (HP:0005406)2.50178437
75Acute myeloid leukemia (HP:0004808)2.50073165
76Reduced antithrombin III activity (HP:0001976)2.49300881
77Meningitis (HP:0001287)2.48689978
78Keratoconjunctivitis sicca (HP:0001097)2.48665061
79* Lymphoma (HP:0002665)2.46416919
80Pulmonary embolism (HP:0002204)2.44266699
81Gastrointestinal stroma tumor (HP:0100723)2.44084351
82Microcytic anemia (HP:0001935)2.43358783
83Acute hepatic failure (HP:0006554)2.41923190
84Gangrene (HP:0100758)2.38962441
85Urticaria (HP:0001025)2.38303272
86Abnormality of the pleura (HP:0002103)2.37528832
87Stomatitis (HP:0010280)2.36132095
88Agammaglobulinemia (HP:0004432)2.36054472
89Chronic mucocutaneous candidiasis (HP:0002728)2.35534094
90Recurrent cutaneous fungal infections (HP:0011370)2.35534094
91Gingival bleeding (HP:0000225)2.35465655
92Recurrent skin infections (HP:0001581)2.35387761
93Chronic sinusitis (HP:0011109)2.35173923
94Skin rash (HP:0000988)2.31681526
95Bronchitis (HP:0012387)2.31447538
96Hepatocellular necrosis (HP:0001404)2.29343852
97Keratoconjunctivitis (HP:0001096)2.29034375
98Granulocytopenia (HP:0001913)2.28929502
99Recurrent gram-negative bacterial infections (HP:0005420)2.28009388
100Colitis (HP:0002583)2.26501266
101Purpura (HP:0000979)2.24926425
102Chronic diarrhea (HP:0002028)2.24692900
103Hypergammaglobulinemia (HP:0010702)2.21180183
1043-Methylglutaconic aciduria (HP:0003535)2.20024067
105Restrictive lung disease (HP:0002091)2.19816451
106Sepsis (HP:0100806)2.18809312
107Erythema (HP:0010783)2.18024233
108Spontaneous hematomas (HP:0007420)2.15930870
109Abnormality of the left ventricular outflow tract (HP:0011103)2.15548065
110Subaortic stenosis (HP:0001682)2.15548065
111Verrucae (HP:0200043)2.15350930
112Papilloma (HP:0012740)2.15350930
113Abnormality of eosinophils (HP:0001879)2.14638166
114Recurrent sinusitis (HP:0011108)2.12734029
115Hypochromic anemia (HP:0001931)2.11481615
116Myelodysplasia (HP:0002863)2.09811400
117Encephalitis (HP:0002383)2.05557163
118Vasculitis (HP:0002633)2.04674854
119Pulmonary fibrosis (HP:0002206)2.01349605
120Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98962216
121Abnormal platelet function (HP:0011869)1.98690834
122Impaired platelet aggregation (HP:0003540)1.98690834
123Abnormality of the prostate (HP:0008775)1.98612968
124Entropion (HP:0000621)1.97816456
125* Pancytopenia (HP:0001876)1.97432600
126Autoimmune hemolytic anemia (HP:0001890)1.96240553
127Chest pain (HP:0100749)1.96188590
128Hepatic necrosis (HP:0002605)1.96131059
129Pustule (HP:0200039)1.94756633
130Ureteral stenosis (HP:0000071)1.94738010
131Mediastinal lymphadenopathy (HP:0100721)1.94665199
132Hemiplegia (HP:0002301)1.94505246
133Leukocytosis (HP:0001974)1.92671998
134Arthralgia (HP:0002829)1.91538180
135Neutropenia (HP:0001875)1.89117424
136Glomerulopathy (HP:0100820)1.88268684
137Eczematoid dermatitis (HP:0000976)1.88202749
138Amyotrophic lateral sclerosis (HP:0007354)1.84173698
139Cellulitis (HP:0100658)1.83804025
140Oral leukoplakia (HP:0002745)1.83259158
141Polyneuropathy (HP:0001271)1.81646853
142Emphysema (HP:0002097)1.81415103
143Ureteral obstruction (HP:0006000)1.81201555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.39413232
2FLT33.60337233
3KIT3.59424152
4NME23.41584374
5TXK3.00707373
6STK162.79690362
7CSK2.63757133
8EEF2K2.56862915
9TEC2.50744227
10ZAP702.35477648
11CSF1R2.28344727
12BTK2.08299089
13JAK32.08235012
14PIM22.01423559
15WEE11.95800980
16CDK191.90174822
17TNIK1.87751079
18KDR1.86341296
19TBK11.86267171
20MAP2K31.81168925
21TGFBR11.76855866
22MAPKAPK51.63073626
23IKBKE1.60477476
24PRKCQ1.60045145
25SCYL21.55336008
26SYK1.54384556
27ADRBK21.51809806
28FES1.45273003
29TESK11.43023010
30MUSK1.39447068
31RPS6KB21.37080228
32BCKDK1.35058390
33TYK21.34716763
34TGFBR21.30945962
35MAP3K121.30916914
36MAPKAPK31.30555853
37NLK1.25734955
38LCK1.25476652
39BLK1.23473950
40IRAK41.22902283
41ITK1.21821082
42ACVR1B1.12441850
43TLK11.09627634
44MAP3K71.06284906
45BUB11.06086137
46LYN1.01150672
47DYRK30.96482338
48RPS6KA40.94075056
49IKBKB0.93858834
50MST40.92808068
51MAP3K110.92667028
52PRPF4B0.89978162
53LRRK20.89889712
54VRK10.88337215
55MAP2K70.87883516
56MATK0.86715373
57RAF10.86563827
58FYN0.85960483
59CCNB10.85866024
60CAMKK20.85387010
61GRK70.81895073
62HCK0.79273069
63NEK20.79101510
64BRSK20.78941902
65CAMKK10.78640334
66CAMK10.78440236
67CDC70.78049054
68MAP3K60.75570189
69TYRO30.75474637
70EIF2AK10.72296240
71MAP2K60.71350840
72MAP3K100.66745133
73PRKG20.66358905
74FGR0.66001031
75PIM10.65854016
76STK100.65306507
77MARK30.64589660
78PASK0.64318148
79GRK60.63113610
80PDK10.62890053
81CDK70.62876594
82DAPK10.60180033
83ATR0.58513845
84MARK20.55923643
85FGFR40.55052569
86TAOK30.54608019
87PKN20.54332782
88MAPK110.54058201
89MAP3K50.53264381
90PRKCH0.53057196
91JAK10.52346941
92TESK20.52106586
93TAOK20.51517148
94SIK30.51215534
95MAP3K140.51047830
96PIK3CA0.50994709
97ILK0.50133616
98EIF2AK30.48274653
99TSSK60.47350978
100MAPK40.46462329
101VRK20.46389394
102TAOK10.45535437
103BMPR20.45384777
104CDK40.45360377
105CAMK40.44716444
106CDK80.43910504
107TNK20.43334987
108INSR0.43233893
109RIPK40.43200830
110HIPK20.42651481
111ERN10.40910730
112MKNK10.38787871
113MAP3K130.38577629
114LIMK10.38176310
115MYLK0.36863366
116MAP3K30.36743545
117PIK3CG0.35507658
118ZAK0.35139672
119MAP3K10.34884455
120RPS6KA50.34523607
121SIK20.34496852
122SRPK10.34316775
123IGF1R0.34091865
124JAK20.33477244
125MAPK120.33415504
126CSNK1G30.33160872
127MAPKAPK20.32450983
128TIE10.31089868
129BRSK10.31014748
130CLK10.30559688
131EPHB10.30054799
132PDGFRB0.29839017
133GRK10.29710214
134NUAK10.27689522
135PAK10.25208874
136ABL10.20688139
137MAPK30.19938138
138CHUK0.19138978
139ROCK10.18908996
140PRKCD0.18686445
141MAPK70.16718927
142MELK0.16182177

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.30452762
2DNA replication_Homo sapiens_hsa030304.01524540
3Primary immunodeficiency_Homo sapiens_hsa053403.88808284
4Mismatch repair_Homo sapiens_hsa034302.95824157
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.82958954
6Base excision repair_Homo sapiens_hsa034102.69621119
7Non-homologous end-joining_Homo sapiens_hsa034502.34344963
8Homologous recombination_Homo sapiens_hsa034402.12985941
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.07862524
10Asthma_Homo sapiens_hsa053102.06909537
11Pyrimidine metabolism_Homo sapiens_hsa002402.05352170
12Antigen processing and presentation_Homo sapiens_hsa046122.03414832
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97644449
14RNA polymerase_Homo sapiens_hsa030201.97215629
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96907487
16Measles_Homo sapiens_hsa051621.84503283
17Leishmaniasis_Homo sapiens_hsa051401.79683756
18Allograft rejection_Homo sapiens_hsa053301.76924323
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76263966
20Spliceosome_Homo sapiens_hsa030401.75361030
21Herpes simplex infection_Homo sapiens_hsa051681.72643056
22Proteasome_Homo sapiens_hsa030501.72480471
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.72172410
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.61477530
25Nucleotide excision repair_Homo sapiens_hsa034201.60673615
26Staphylococcus aureus infection_Homo sapiens_hsa051501.60559836
27B cell receptor signaling pathway_Homo sapiens_hsa046621.58366139
28Rheumatoid arthritis_Homo sapiens_hsa053231.57671845
29Hematopoietic cell lineage_Homo sapiens_hsa046401.57422393
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56723557
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.50806506
32T cell receptor signaling pathway_Homo sapiens_hsa046601.44167961
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.43485900
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.35853728
35RNA degradation_Homo sapiens_hsa030181.35159997
36Sulfur relay system_Homo sapiens_hsa041221.29614425
37Acute myeloid leukemia_Homo sapiens_hsa052211.27487002
38Shigellosis_Homo sapiens_hsa051311.16885388
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11241969
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08647782
41Pentose phosphate pathway_Homo sapiens_hsa000301.08203186
42N-Glycan biosynthesis_Homo sapiens_hsa005101.07765093
43Legionellosis_Homo sapiens_hsa051341.05342827
44Folate biosynthesis_Homo sapiens_hsa007901.03108184
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03003239
46Purine metabolism_Homo sapiens_hsa002301.01178027
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96803317
48Osteoclast differentiation_Homo sapiens_hsa043800.96411015
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95865949
50Thyroid cancer_Homo sapiens_hsa052160.93132322
51Epstein-Barr virus infection_Homo sapiens_hsa051690.92027249
52Protein export_Homo sapiens_hsa030600.91862476
53Influenza A_Homo sapiens_hsa051640.91535124
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89457194
55Fanconi anemia pathway_Homo sapiens_hsa034600.88043987
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86167358
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85690070
58Hepatitis B_Homo sapiens_hsa051610.84404809
59One carbon pool by folate_Homo sapiens_hsa006700.84171602
60Pertussis_Homo sapiens_hsa051330.79290848
61Toxoplasmosis_Homo sapiens_hsa051450.78431728
62Malaria_Homo sapiens_hsa051440.78305860
63* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77370356
64Other glycan degradation_Homo sapiens_hsa005110.76542883
65Platelet activation_Homo sapiens_hsa046110.76311121
66RNA transport_Homo sapiens_hsa030130.74900137
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.74519292
68Type I diabetes mellitus_Homo sapiens_hsa049400.73723880
69Cell cycle_Homo sapiens_hsa041100.73654552
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71355312
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70115597
72Caffeine metabolism_Homo sapiens_hsa002320.66349252
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66101942
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65141591
75Apoptosis_Homo sapiens_hsa042100.65134358
76Salmonella infection_Homo sapiens_hsa051320.63312252
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.62571976
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62001066
79p53 signaling pathway_Homo sapiens_hsa041150.61910980
80Graft-versus-host disease_Homo sapiens_hsa053320.58997873
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58129053
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57591738
83Tuberculosis_Homo sapiens_hsa051520.57506892
84HTLV-I infection_Homo sapiens_hsa051660.57027266
85Oxidative phosphorylation_Homo sapiens_hsa001900.56109679
86African trypanosomiasis_Homo sapiens_hsa051430.55989241
87Viral carcinogenesis_Homo sapiens_hsa052030.55523008
88Phagosome_Homo sapiens_hsa041450.51850440
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.50838030
90Basal transcription factors_Homo sapiens_hsa030220.50365680
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49877849
92TNF signaling pathway_Homo sapiens_hsa046680.47761304
93Parkinsons disease_Homo sapiens_hsa050120.47106726
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46097496
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43890208
96Endocytosis_Homo sapiens_hsa041440.43592691
97Viral myocarditis_Homo sapiens_hsa054160.42600592
98Regulation of autophagy_Homo sapiens_hsa041400.41433219
99Non-small cell lung cancer_Homo sapiens_hsa052230.35755308
100Chronic myeloid leukemia_Homo sapiens_hsa052200.35716660
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35594818
102Chemokine signaling pathway_Homo sapiens_hsa040620.34940224
103Galactose metabolism_Homo sapiens_hsa000520.32713583
104Alcoholism_Homo sapiens_hsa050340.31781920
105Systemic lupus erythematosus_Homo sapiens_hsa053220.31308940
106Colorectal cancer_Homo sapiens_hsa052100.30326739
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30032216
108Hepatitis C_Homo sapiens_hsa051600.29948190
109Pancreatic cancer_Homo sapiens_hsa052120.29606395
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25641088
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24386651
112MAPK signaling pathway_Homo sapiens_hsa040100.23859405
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.23484374
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.23277614
115Prion diseases_Homo sapiens_hsa050200.22738053
116VEGF signaling pathway_Homo sapiens_hsa043700.22526851
117Autoimmune thyroid disease_Homo sapiens_hsa053200.22357916
118Alzheimers disease_Homo sapiens_hsa050100.21956113
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21019734
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20958633
121Phototransduction_Homo sapiens_hsa047440.17831756
122Linoleic acid metabolism_Homo sapiens_hsa005910.17615474
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17455680
124Nitrogen metabolism_Homo sapiens_hsa009100.13048280
125Ras signaling pathway_Homo sapiens_hsa040140.07512716
126Olfactory transduction_Homo sapiens_hsa047400.05729521
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.04449719
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.00384993
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.00259652
130Huntingtons disease_Homo sapiens_hsa05016-0.0623850
131FoxO signaling pathway_Homo sapiens_hsa04068-0.0418332
132Collecting duct acid secretion_Homo sapiens_hsa04966-0.0237424
133Phosphatidylinositol signaling system_Homo sapiens_hsa04070-0.0234309
134Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0224032
135Lysosome_Homo sapiens_hsa04142-0.0117501
136Rap1 signaling pathway_Homo sapiens_hsa04015-0.0109669

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