CD274

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.44708504
2neutrophil activation involved in immune response (GO:0002283)5.26357222
3regulation of vitamin metabolic process (GO:0030656)5.09540999
4positive regulation by symbiont of host defense response (GO:0052509)4.97576235
5modulation by symbiont of host defense response (GO:0052031)4.97576235
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.97576235
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.97576235
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.97576235
9modulation by symbiont of host immune response (GO:0052553)4.97576235
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.96160790
11negative regulation of interleukin-12 production (GO:0032695)4.92924307
12regulation of podosome assembly (GO:0071801)4.71050594
13positive regulation of interferon-alpha production (GO:0032727)4.61214737
14response to peptidoglycan (GO:0032494)4.54659469
15regulation of interferon-alpha production (GO:0032647)4.39978788
16type I interferon signaling pathway (GO:0060337)4.38276290
17cellular response to type I interferon (GO:0071357)4.38276290
18response to type I interferon (GO:0034340)4.35452614
19antigen processing and presentation of endogenous antigen (GO:0019883)4.34056896
20regulation of cytokine secretion involved in immune response (GO:0002739)4.23341920
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.20465147
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.20465147
23granulocyte activation (GO:0036230)4.12963985
24regulation of T-helper 1 cell differentiation (GO:0045625)4.08188487
25positive regulation of type 2 immune response (GO:0002830)4.04533940
26neutrophil activation (GO:0042119)4.00611495
27regulation of dendritic cell antigen processing and presentation (GO:0002604)3.97519414
28natural killer cell mediated cytotoxicity (GO:0042267)3.96705494
29natural killer cell mediated immunity (GO:0002228)3.96705494
30T-helper 1 type immune response (GO:0042088)3.90755434
31response to muramyl dipeptide (GO:0032495)3.87021947
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.86843424
33lipopolysaccharide-mediated signaling pathway (GO:0031663)3.86384007
34respiratory burst (GO:0045730)3.82071485
35immunoglobulin mediated immune response (GO:0016064)3.77402102
36positive regulation of antigen processing and presentation (GO:0002579)3.75244560
37positive regulation of T cell cytokine production (GO:0002726)3.74245317
38positive regulation of interleukin-12 production (GO:0032735)3.71928131
39NIK/NF-kappaB signaling (GO:0038061)3.71428496
40positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.70801405
41positive regulation of chemokine biosynthetic process (GO:0045080)3.68162577
42myeloid dendritic cell differentiation (GO:0043011)3.64946453
43macrophage activation involved in immune response (GO:0002281)3.64742571
44interferon-gamma-mediated signaling pathway (GO:0060333)3.64232511
45regulation of interferon-beta biosynthetic process (GO:0045357)3.62638260
46positive regulation of interleukin-17 production (GO:0032740)3.57672592
47regulation of interleukin-12 biosynthetic process (GO:0045075)3.57500731
48positive regulation of gamma-delta T cell activation (GO:0046645)3.53527916
49positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.50377865
50response to host immune response (GO:0052572)3.48475534
51response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.48475534
52dendritic cell differentiation (GO:0097028)3.47425194
53hydrogen peroxide biosynthetic process (GO:0050665)3.47038244
54negative regulation of viral genome replication (GO:0045071)3.46812470
55regulation of RIG-I signaling pathway (GO:0039535)3.46735367
56defense response to protozoan (GO:0042832)3.44756336
57positive regulation of heat generation (GO:0031652)3.43307414
58positive regulation of NF-kappaB import into nucleus (GO:0042346)3.42637114
59cellular response to interferon-beta (GO:0035458)3.42361158
60regulation of mononuclear cell migration (GO:0071675)3.41503833
61superoxide anion generation (GO:0042554)3.39581087
62modulation of growth of symbiont involved in interaction with host (GO:0044144)3.38332422
63regulation of growth of symbiont in host (GO:0044126)3.38332422
64negative regulation of growth of symbiont in host (GO:0044130)3.38332422
65negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.38332422
66T cell migration (GO:0072678)3.37740287
67positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.36389424
68regulation of membrane protein ectodomain proteolysis (GO:0051043)3.36353041
69positive regulation of interferon-beta production (GO:0032728)3.34577701
70regulation of fever generation (GO:0031620)3.34479364
71regulation of T cell tolerance induction (GO:0002664)3.34238432
72regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.33757886
73germinal center formation (GO:0002467)3.33319138
74myeloid dendritic cell activation (GO:0001773)3.31589596
75positive regulation of natural killer cell differentiation (GO:0032825)3.31492820
76positive regulation of toll-like receptor signaling pathway (GO:0034123)3.28762643
77regulation of antigen processing and presentation (GO:0002577)3.28346183
78regulation of interleukin-17 production (GO:0032660)3.26691066
79regulation of activation of Janus kinase activity (GO:0010533)3.26506300
80positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.25748869
81negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.25537020
82cellular response to lipopolysaccharide (GO:0071222)3.22978574
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.22687605
84negative regulation of cytokine production involved in immune response (GO:0002719)3.22153700
85regulation of immunoglobulin secretion (GO:0051023)3.21677668
86myeloid cell activation involved in immune response (GO:0002275)3.21226986
87response to interferon-alpha (GO:0035455)3.20814005
88positive regulation of defense response to virus by host (GO:0002230)3.20792635
89branching involved in labyrinthine layer morphogenesis (GO:0060670)3.19499154
90positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.18404771
91regulation of chemokine biosynthetic process (GO:0045073)3.16887904
92regulation of type 2 immune response (GO:0002828)3.15517537
93cellular response to molecule of bacterial origin (GO:0071219)3.14816994
94positive regulation of nitric oxide biosynthetic process (GO:0045429)3.12396554
95response to interferon-gamma (GO:0034341)3.09761018
96negative regulation of interleukin-17 production (GO:0032700)3.08951750
97positive regulation of T-helper cell differentiation (GO:0045624)3.08005504
98regulation of type I interferon-mediated signaling pathway (GO:0060338)3.07894141
99regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.07795554
100regulation of interleukin-12 production (GO:0032655)3.07401859
101cellular response to exogenous dsRNA (GO:0071360)3.06511498
102positive regulation of alpha-beta T cell proliferation (GO:0046641)3.06143958
103regulation of alpha-beta T cell proliferation (GO:0046640)3.06122176
104regulation of nitric oxide biosynthetic process (GO:0045428)3.05259232
105positive regulation of interleukin-2 production (GO:0032743)3.04714112
106eosinophil chemotaxis (GO:0048245)3.04483626
107regulation of chronic inflammatory response (GO:0002676)3.04466605
108positive regulation of cellular amide metabolic process (GO:0034250)3.03907971
109microglial cell activation (GO:0001774)3.03472872
110reactive oxygen species biosynthetic process (GO:1903409)3.02938393
111positive regulation of humoral immune response (GO:0002922)3.02918273
112regulation of interleukin-8 biosynthetic process (GO:0045414)3.01946574
113regulation of response to interferon-gamma (GO:0060330)3.01738890
114regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.01738542
115negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.01639776
116response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01461970
117response to host (GO:0075136)3.01461970
118response to host defenses (GO:0052200)3.01461970
119monocyte chemotaxis (GO:0002548)3.00780901
120lymphocyte chemotaxis (GO:0048247)3.00621530
121leukocyte mediated cytotoxicity (GO:0001909)2.99643304
122positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.99638484
123regulation of T-helper cell differentiation (GO:0045622)2.98532105
124regulation of interleukin-1 beta secretion (GO:0050706)2.98210043
125negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.98023073
126negative regulation of cell killing (GO:0031342)2.98023073
127positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97830798
128regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.96915227
129positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.96563219
130positive regulation of interleukin-1 beta secretion (GO:0050718)2.95049175
131response to interferon-beta (GO:0035456)2.94888065
132cellular response to interferon-gamma (GO:0071346)2.94812441
133negative regulation of nitric oxide biosynthetic process (GO:0045019)2.94430024
134positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.94225690
135regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.93748693
136response to protozoan (GO:0001562)2.93354822
137positive regulation of interleukin-6 production (GO:0032755)2.91937637
138regulation of T-helper 2 cell differentiation (GO:0045628)2.90495996
139positive regulation of cytokine biosynthetic process (GO:0042108)2.90229731
140regulation of interferon-gamma biosynthetic process (GO:0045072)2.89970115
141regulation of inflammatory response to antigenic stimulus (GO:0002861)2.89343214
142regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.89175963
143regulation of T cell cytokine production (GO:0002724)2.89109173
144regulation of T-helper 1 type immune response (GO:0002825)2.87631469
145regulation of NF-kappaB import into nucleus (GO:0042345)2.85203506

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.33776977
2* IRF8_21731497_ChIP-ChIP_J774_Mouse6.71776383
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.69250132
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.08703545
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.88507168
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.69389776
7* IRF8_27001747_Chip-Seq_BMDM_Mouse4.24329403
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.67214101
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.35679977
10* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.23122347
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.14989914
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.10930668
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.08407564
14* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.81630212
15* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80525667
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56735474
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42564779
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08641906
19RUNX_20019798_ChIP-Seq_JUKART_Human2.01182137
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96977521
21VDR_24787735_ChIP-Seq_THP-1_Human1.84532451
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.71536973
23MYB_26560356_Chip-Seq_TH2_Human1.67541737
24PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64329619
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63259085
26* SPI1_23547873_ChIP-Seq_NB4_Human1.62909911
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59784559
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.58928078
29PU_27001747_Chip-Seq_BMDM_Mouse1.55394432
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52288226
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50305378
32CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43207141
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42841523
34CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40344563
35SCL_19346495_ChIP-Seq_HPC-7_Human1.38694365
36VDR_24763502_ChIP-Seq_THP-1_Human1.38628164
37MAF_26560356_Chip-Seq_TH1_Human1.35195834
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.29459378
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28796760
40MYB_26560356_Chip-Seq_TH1_Human1.27349937
41SPI1_23127762_ChIP-Seq_K562_Human1.26248176
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24272639
43GATA1_22025678_ChIP-Seq_K562_Human1.24241359
44GATA3_26560356_Chip-Seq_TH2_Human1.23083445
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.22927894
46GATA3_27048872_Chip-Seq_THYMUS_Human1.22699311
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.22627497
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19963929
49EGR1_19032775_ChIP-ChIP_M12_Human1.19611973
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18898933
51CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14237684
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13809874
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.13210399
54* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12591495
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10644614
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08644250
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07820423
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07820423
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04874979
60TCF7_22412390_ChIP-Seq_EML_Mouse1.03205236
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02091118
62GATA1_19941826_ChIP-Seq_K562_Human0.97968392
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97821697
64KDM2B_26808549_Chip-Seq_DND41_Human0.96993419
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96227722
66MYC_22102868_ChIP-Seq_BL_Human0.95873324
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95502322
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93509580
69* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91416820
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90905047
71NOTCH1_21737748_ChIP-Seq_TLL_Human0.90207978
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89894835
73STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89818851
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88716392
75TFEB_21752829_ChIP-Seq_HELA_Human0.87748245
76LXR_22292898_ChIP-Seq_THP-1_Human0.87679447
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87501962
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86212092
79STAT1_20625510_ChIP-Seq_HELA_Human0.85074844
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84818345
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83895341
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83284399
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82433331
84SOX2_20726797_ChIP-Seq_SW620_Human0.81839190
85GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80322693
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79629891
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79576181
88TP63_17297297_ChIP-ChIP_HaCaT_Human0.79505834
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78713447
90SMRT_27268052_Chip-Seq_Bcells_Human0.78693093
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75965074
92ESR1_21235772_ChIP-Seq_MCF-7_Human0.75171153
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74468973
94* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74231410
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73669334
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.73587497
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72189456
98UBF1/2_26484160_Chip-Seq_HMECs_Human0.71874420
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.70820231
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.70764953
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69800449
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.69741918
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.69741918
104CJUN_26792858_Chip-Seq_BT549_Human0.68547045
105VDR_21846776_ChIP-Seq_THP-1_Human0.67276304
106MAF_26560356_Chip-Seq_TH2_Human0.67138068
107* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65739454
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63798140
109* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63284960
110SUZ12_18555785_Chip-Seq_ESCs_Mouse0.62892352
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.62866658
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62588152
113CMYC_18555785_Chip-Seq_ESCs_Mouse0.62338320
114PU1_27457419_Chip-Seq_LIVER_Mouse0.62139007
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61562658
116KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.61358005
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.61287562
118ER_23166858_ChIP-Seq_MCF-7_Human0.60700841
119UTX_26944678_Chip-Seq_JUKART_Human0.60689723
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.59697455
121GATA2_19941826_ChIP-Seq_K562_Human0.58724870
122* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.58429726
123* GATA1_19941827_ChIP-Seq_MEL_Mouse0.57819019
124STAT3_18555785_Chip-Seq_ESCs_Mouse0.57408423
125SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.56615868
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.56615868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.92155564
2MP0009785_altered_susceptibility_to4.06515375
3MP0002148_abnormal_hypersensitivity_rea3.71946177
4MP0003436_decreased_susceptibility_to3.60295843
5MP0006082_CNS_inflammation3.43498985
6MP0004510_myositis3.43143403
7* MP0005000_abnormal_immune_tolerance3.36866053
8MP0005671_abnormal_response_to3.31312093
9MP0003724_increased_susceptibility_to3.27848537
10MP0000685_abnormal_immune_system3.27723734
11MP0003303_peritoneal_inflammation3.22869049
12* MP0001790_abnormal_immune_system3.21126561
13* MP0005387_immune_system_phenotype3.21126561
14MP0002419_abnormal_innate_immunity3.09406810
15* MP0005025_abnormal_response_to3.06974459
16MP0001800_abnormal_humoral_immune2.74136111
17* MP0002452_abnormal_antigen_presenting2.73953178
18* MP0002723_abnormal_immune_serum2.69993960
19* MP0001819_abnormal_immune_cell2.35168937
20* MP0002420_abnormal_adaptive_immunity2.30779743
21MP0005058_abnormal_lysosome_morphology2.18739951
22MP0001533_abnormal_skeleton_physiology2.04577077
23MP0004947_skin_inflammation2.04028649
24MP0001853_heart_inflammation2.01652363
25MP0005310_abnormal_salivary_gland1.91800007
26MP0002006_tumorigenesis1.85602168
27MP0002405_respiratory_system_inflammati1.84450958
28MP0003448_altered_tumor_morphology1.81985415
29MP0009764_decreased_sensitivity_to1.81943671
30MP0002139_abnormal_hepatobiliary_system1.81354991
31MP0001845_abnormal_inflammatory_respons1.80969236
32MP0005464_abnormal_platelet_physiology1.77063445
33MP0008004_abnormal_stomach_pH1.70126620
34MP0010155_abnormal_intestine_physiology1.69278126
35* MP0000716_abnormal_immune_system1.68883405
36MP0008469_abnormal_protein_level1.57783450
37MP0002998_abnormal_bone_remodeling1.53224751
38MP0002398_abnormal_bone_marrow1.52844543
39MP0003075_altered_response_to1.52583664
40MP0002166_altered_tumor_susceptibility1.52042060
41MP0009333_abnormal_splenocyte_physiolog1.49923097
42MP0000604_amyloidosis1.48149828
43MP0002254_reproductive_system_inflammat1.46319165
44MP0002138_abnormal_hepatobiliary_system1.43590543
45MP0000920_abnormal_myelination1.43056542
46MP0003690_abnormal_glial_cell1.41637665
47MP0003172_abnormal_lysosome_physiology1.40738105
48MP0002277_abnormal_respiratory_mucosa1.39769558
49MP0009278_abnormal_bone_marrow1.39513339
50MP0000343_altered_response_to1.37345443
51MP0006054_spinal_hemorrhage1.36244986
52* MP0002429_abnormal_blood_cell1.26054891
53MP0003806_abnormal_nucleotide_metabolis1.23651987
54MP0008260_abnormal_autophagy1.21617213
55MP0000689_abnormal_spleen_morphology1.15794296
56MP0001348_abnormal_lacrimal_gland1.15692472
57MP0001851_eye_inflammation1.15035806
58MP0002933_joint_inflammation1.13156089
59MP0003656_abnormal_erythrocyte_physiolo1.08857528
60MP0000569_abnormal_digit_pigmentation1.08149444
61MP0002722_abnormal_immune_system1.07411537
62MP0004782_abnormal_surfactant_physiolog1.06017330
63MP0003763_abnormal_thymus_physiology1.04171939
64MP0005164_abnormal_response_to1.04033417
65MP0003300_gastrointestinal_ulcer1.03215596
66MP0001545_abnormal_hematopoietic_system0.98926239
67MP0005397_hematopoietic_system_phenotyp0.98926239
68MP0005166_decreased_susceptibility_to0.98889848
69MP0000858_altered_metastatic_potential0.98533396
70MP0009840_abnormal_foam_cell0.95788435
71MP0003453_abnormal_keratinocyte_physiol0.95742548
72MP0005390_skeleton_phenotype0.94950586
73MP0003191_abnormal_cellular_cholesterol0.93170141
74MP0003186_abnormal_redox_activity0.92637084
75MP0005174_abnormal_tail_pigmentation0.89950631
76MP0005167_abnormal_blood-brain_barrier0.89370271
77MP0001663_abnormal_digestive_system0.88416822
78MP0009763_increased_sensitivity_to0.87682365
79MP0002877_abnormal_melanocyte_morpholog0.86942296
80MP0005165_increased_susceptibility_to0.86367879
81MP0010352_gastrointestinal_tract_polyps0.82088890
82MP0001542_abnormal_bone_strength0.80227315
83MP0002163_abnormal_gland_morphology0.79550290
84MP0001873_stomach_inflammation0.79535905
85MP0003646_muscle_fatigue0.77632665
86MP0005023_abnormal_wound_healing0.77556276
87MP0005171_absent_coat_pigmentation0.76366244
88MP0003136_yellow_coat_color0.75757657
89MP0008874_decreased_physiological_sensi0.75615697
90MP0001346_abnormal_lacrimal_gland0.73655702
91MP0003091_abnormal_cell_migration0.70801908
92MP0004808_abnormal_hematopoietic_stem0.70326237
93MP0003828_pulmonary_edema0.69015268
94MP0000015_abnormal_ear_pigmentation0.68904846
95MP0000249_abnormal_blood_vessel0.67876042
96MP0004858_abnormal_nervous_system0.63487341
97MP0003045_fibrosis0.63346599
98MP0004883_abnormal_blood_vessel0.63104884
99MP0003866_abnormal_defecation0.61190037
100MP0000465_gastrointestinal_hemorrhage0.60098519
101MP0001881_abnormal_mammary_gland0.59374668
102MP0002332_abnormal_exercise_endurance0.57822437
103MP0003950_abnormal_plasma_membrane0.57757468
104MP0002136_abnormal_kidney_physiology0.57227750
105MP0003195_calcinosis0.56716012
106MP0005647_abnormal_sex_gland0.56370227
107MP0005076_abnormal_cell_differentiation0.56241463
108MP0000703_abnormal_thymus_morphology0.56175601
109MP0005451_abnormal_body_composition0.56003169
110MP0004742_abnormal_vestibular_system0.55857431
111MP0002693_abnormal_pancreas_physiology0.55795932
112MP0003795_abnormal_bone_structure0.55134341
113MP0003183_abnormal_peptide_metabolism0.54690253
114MP0010307_abnormal_tumor_latency0.54630461
115MP0005266_abnormal_metabolism0.54515437
116MP0003221_abnormal_cardiomyocyte_apopto0.54002249
117MP0003329_amyloid_beta_deposits0.53457194
118MP0000371_diluted_coat_color0.53356628
119MP0005535_abnormal_body_temperature0.52895428
120MP0005381_digestive/alimentary_phenotyp0.52462749
121MP0001501_abnormal_sleep_pattern0.51798267
122MP0009765_abnormal_xenobiotic_induced0.51373262

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.91204062
2Recurrent abscess formation (HP:0002722)6.65115018
3Recurrent bacterial skin infections (HP:0005406)6.21920200
4Recurrent gram-negative bacterial infections (HP:0005420)5.43122179
5Abnormality of macrophages (HP:0004311)5.34682576
6Stomatitis (HP:0010280)5.22606410
7Elevated erythrocyte sedimentation rate (HP:0003565)5.02086388
8Mediastinal lymphadenopathy (HP:0100721)5.00196358
9Optic neuritis (HP:0100653)4.73511246
10Retrobulbar optic neuritis (HP:0100654)4.73511246
11Orchitis (HP:0100796)4.49887097
12Increased IgM level (HP:0003496)4.42869303
13Myositis (HP:0100614)4.34459242
14Recurrent skin infections (HP:0001581)4.26592854
15Autoimmune thrombocytopenia (HP:0001973)4.22206197
16Recurrent fungal infections (HP:0002841)4.18609658
17Chronic otitis media (HP:0000389)4.12759054
18Vasculitis (HP:0002633)4.05587325
19Recurrent viral infections (HP:0004429)3.90969669
20Gingivitis (HP:0000230)3.81501094
21Obstructive lung disease (HP:0006536)3.80182330
22Chronic obstructive pulmonary disease (HP:0006510)3.80182330
23Dysostosis multiplex (HP:0000943)3.55684744
24Recurrent cutaneous fungal infections (HP:0011370)3.30068437
25Chronic mucocutaneous candidiasis (HP:0002728)3.30068437
26Increased cerebral lipofuscin (HP:0011813)3.26670846
27Pulmonary infiltrates (HP:0002113)3.25152927
28Basal ganglia calcification (HP:0002135)3.19818811
29Vacuolated lymphocytes (HP:0001922)3.19397101
30Increased neuronal autofluorescent lipopigment (HP:0002074)3.15347987
31Hypergammaglobulinemia (HP:0010702)3.06932846
32Interstitial pulmonary disease (HP:0006530)3.02904139
33Thick nail (HP:0001805)3.02037847
34Prostate neoplasm (HP:0100787)2.98273973
35Gastrointestinal infarctions (HP:0005244)2.93921289
36Cellulitis (HP:0100658)2.92728787
37Nuclear cataract (HP:0100018)2.91182619
38Meningitis (HP:0001287)2.86807633
39Mutism (HP:0002300)2.86661529
40Abnormality of T cell number (HP:0011839)2.84461257
41Leukocytosis (HP:0001974)2.84407390
42Recurrent pneumonia (HP:0006532)2.81748667
43Systemic lupus erythematosus (HP:0002725)2.79103918
44Axonal loss (HP:0003447)2.75976086
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.73440341
46Urticaria (HP:0001025)2.67397631
47Tetraparesis (HP:0002273)2.64252948
48Hematochezia (HP:0002573)2.62936884
49Nasal polyposis (HP:0100582)2.62912957
50Keratoconjunctivitis sicca (HP:0001097)2.61790372
51Gingival bleeding (HP:0000225)2.61738620
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61522374
53Abnormality of polysaccharide metabolism (HP:0011012)2.61522374
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61522374
55Hepatosplenomegaly (HP:0001433)2.60628275
56Hemoptysis (HP:0002105)2.60343455
57Parakeratosis (HP:0001036)2.58841123
58Periodontitis (HP:0000704)2.57300044
59Arterial thrombosis (HP:0004420)2.55962594
60Glomerulonephritis (HP:0000099)2.53701170
61Keratoconjunctivitis (HP:0001096)2.52136348
62Recurrent bronchitis (HP:0002837)2.51843506
63Pustule (HP:0200039)2.51626394
64Porencephaly (HP:0002132)2.50882532
65Osteomyelitis (HP:0002754)2.50653253
66Encephalitis (HP:0002383)2.50021971
67T lymphocytopenia (HP:0005403)2.49529659
68Mucopolysacchariduria (HP:0008155)2.49353127
69Urinary glycosaminoglycan excretion (HP:0003541)2.49353127
70Myocardial infarction (HP:0001658)2.47769148
71Increased serum ferritin (HP:0003281)2.46033089
72Polyneuropathy (HP:0001271)2.45914881
73Recurrent lower respiratory tract infections (HP:0002783)2.43339102
74Premature loss of primary teeth (HP:0006323)2.37540595
75Abnormality of the pleura (HP:0002103)2.37511069
76Apathy (HP:0000741)2.37409207
77Autoimmune hemolytic anemia (HP:0001890)2.35809928
78Abnormality of liposaccharide metabolism (HP:0010968)2.35311100
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.35311100
80Abnormality of glycolipid metabolism (HP:0010969)2.35311100
81Gastrointestinal stroma tumor (HP:0100723)2.34550346
82Abnormality of the nasal mucosa (HP:0000433)2.31054776
83Eosinophilia (HP:0001880)2.30648850
84Diminished motivation (HP:0000745)2.27013310
85Loss of speech (HP:0002371)2.25685160
86Progressive neurologic deterioration (HP:0002344)2.25394299
87Abnormality of B cell number (HP:0010975)2.24722157
88B lymphocytopenia (HP:0010976)2.20330364
89Abnormal delayed hypersensitivity skin test (HP:0002963)2.18999168
90Amyloidosis (HP:0011034)2.17689182
91Hypertensive crisis (HP:0100735)2.17197574
92Abnormality of T cells (HP:0002843)2.15877823
93Chronic sinusitis (HP:0011109)2.15786951
94Glomerulopathy (HP:0100820)2.13736902
95Abnormality of eosinophils (HP:0001879)2.11526575
96Abnormality of the endocardium (HP:0004306)2.10736817
97Prolonged neonatal jaundice (HP:0006579)2.08715878
98Metaphyseal irregularity (HP:0003025)2.08550457
99Pulmonary embolism (HP:0002204)2.08378927
100Peritonitis (HP:0002586)2.08064142
101Disinhibition (HP:0000734)2.06675094
102Vertigo (HP:0002321)2.06202997
103Osteolytic defects of the phalanges of the hand (HP:0009771)2.06190118
104Osteolytic defects of the hand bones (HP:0009699)2.06190118
105Spontaneous hematomas (HP:0007420)2.05131799
106Agammaglobulinemia (HP:0004432)2.04706586
107Emphysema (HP:0002097)2.04208239
108Keratitis (HP:0000491)2.04038268
109Neurofibrillary tangles (HP:0002185)2.01981500
110Cerebral inclusion bodies (HP:0100314)2.01288204
111Abnormality of T cell physiology (HP:0011840)2.00820673
112Gangrene (HP:0100758)2.00622780
113Purpura (HP:0000979)2.00313432
114Thin bony cortex (HP:0002753)2.00103701
115Arthralgia (HP:0002829)1.98734781
116Petechiae (HP:0000967)1.97608065
117Amaurosis fugax (HP:0100576)1.96831579
118Sepsis (HP:0100806)1.96040890
119Granulocytopenia (HP:0001913)1.95307884
120Acne (HP:0001061)1.95296333
121Colitis (HP:0002583)1.94800662
122Increased IgE level (HP:0003212)1.94403396
123Joint swelling (HP:0001386)1.94047776
124Abnormality of the pericardium (HP:0001697)1.93202536
125Neuronal loss in central nervous system (HP:0002529)1.93165080
126Anorexia (HP:0002039)1.92798807
127IgA deficiency (HP:0002720)1.92695674
128Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92442338
129Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92368883
130Chest pain (HP:0100749)1.91905718
131Memory impairment (HP:0002354)1.91867823
132Segmental peripheral demyelination/remyelination (HP:0003481)1.91082722
133Bone pain (HP:0002653)1.89503662
134Abnormality of cells of the lymphoid lineage (HP:0012140)1.89347496
135IgG deficiency (HP:0004315)1.87912687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.79328640
2PBK4.45939638
3RIPK43.56946830
4TBK13.56862373
5BLK3.49164080
6TYK23.17837780
7IKBKE3.15353819
8JAK32.89052752
9IRAK42.85338279
10IKBKB2.83461064
11DDR22.77022985
12TAOK22.69144177
13IRAK32.62594717
14MAP4K12.59403977
15EPHB12.56751484
16PRPF4B2.56510406
17TXK2.42859647
18RIPK12.36558598
19JAK12.23678745
20MAP3K132.20268164
21KIT2.05366051
22CHUK1.72056608
23PIM21.71614033
24MST41.68488754
25CDC42BPA1.58452020
26BMPR21.56695001
27MAP3K111.51410880
28TAOK11.50787762
29CSK1.48960127
30MAP3K31.43274338
31FGFR41.31375766
32FGR1.29694242
33SYK1.27675153
34EPHA31.26200070
35PKN11.21618338
36IRAK11.21226461
37LCK1.19524422
38BMX1.18463129
39HCK1.17571487
40STK391.16664185
41ZAP701.13042929
42FGFR31.01779432
43LYN0.99928955
44STK40.99860207
45BTK0.97894082
46CSF1R0.97103339
47JAK20.95145250
48MARK30.94812309
49PIM10.94144772
50TAOK30.92308513
51TEC0.89556553
52IRAK20.89279857
53PRKCQ0.84159741
54TYRO30.83577176
55EIF2AK20.83572097
56LATS20.83472463
57ABL20.83276118
58CLK10.79687646
59PDGFRA0.78537391
60FES0.75320609
61YES10.72624443
62ERN10.71967839
63ITK0.70228094
64BCR0.69806554
65STK100.69498685
66ABL10.68559819
67GRK70.64249823
68RPS6KA50.63980182
69MATK0.63604437
70SIK30.62338968
71NLK0.61879124
72NEK90.61208632
73MAP2K60.58814131
74MST1R0.57139910
75PRKCD0.56387014
76EGFR0.55398941
77BMPR1B0.53731918
78TRPM70.51716425
79ARAF0.49996665
80CDK60.49840397
81RPS6KA40.49533204
82ACVR1B0.47380064
83WNK10.45969867
84STK30.45246532
85ADRBK20.44906134
86NME20.41404698
87MAPKAPK20.39014634
88MAP3K50.38937616
89MAPK40.38652204
90MAP3K10.38477763
91FYN0.37845088
92STK240.36823355
93DYRK30.35257368
94TESK20.33673374
95TTN0.32748414
96CDK40.31570242
97OXSR10.30003880
98SIK20.29750851
99MOS0.29592418
100MAPKAPK50.29412866
101INSR0.29293562
102PAK40.28573581
103ERBB40.28135603
104GSK3A0.28074176
105TGFBR20.28070435
106PDPK10.27577749
107PDGFRB0.26891324
108PRKCE0.26092842
109DAPK20.25205298
110MAPK70.25046630
111NEK60.24647449
112PDK10.24277604
113SIK10.23901114
114MET0.23569347
115RPS6KL10.22790914
116RPS6KC10.22790914
117DAPK30.22710568
118EIF2AK30.22124207
119NUAK10.20832912
120MAP3K80.18127756
121IGF1R0.17965377
122LRRK20.17929368
123MELK0.17660248
124RPS6KA10.17641967
125MAPK110.17580712
126SGK10.16964961
127SRC0.16101289
128CAMKK20.15924319
129HIPK20.15753262
130RPS6KA60.15198037
131MAP2K30.13976874

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.54053859
2Allograft rejection_Homo sapiens_hsa053303.41066823
3Leishmaniasis_Homo sapiens_hsa051403.16498307
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.91468188
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.84190112
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.78567430
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.49622807
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.40840700
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.33428958
10Measles_Homo sapiens_hsa051622.32819618
11Asthma_Homo sapiens_hsa053102.28424340
12Staphylococcus aureus infection_Homo sapiens_hsa051502.26950027
13Malaria_Homo sapiens_hsa051442.25911997
14Rheumatoid arthritis_Homo sapiens_hsa053232.25010542
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24224236
16Osteoclast differentiation_Homo sapiens_hsa043802.22058956
17Type I diabetes mellitus_Homo sapiens_hsa049402.15323990
18Legionellosis_Homo sapiens_hsa051342.15154757
19Pertussis_Homo sapiens_hsa051332.11932513
20Autoimmune thyroid disease_Homo sapiens_hsa053202.05957217
21TNF signaling pathway_Homo sapiens_hsa046682.04809259
22Tuberculosis_Homo sapiens_hsa051521.96726361
23Influenza A_Homo sapiens_hsa051641.88131357
24African trypanosomiasis_Homo sapiens_hsa051431.71256573
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.65742191
26Salmonella infection_Homo sapiens_hsa051321.60008531
27Herpes simplex infection_Homo sapiens_hsa051681.59714644
28Toxoplasmosis_Homo sapiens_hsa051451.58616126
29Chemokine signaling pathway_Homo sapiens_hsa040621.58311791
30B cell receptor signaling pathway_Homo sapiens_hsa046621.57149048
31Primary immunodeficiency_Homo sapiens_hsa053401.57002066
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.49623400
33Hematopoietic cell lineage_Homo sapiens_hsa046401.46060918
34Phagosome_Homo sapiens_hsa041451.37527015
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35428090
36Lysosome_Homo sapiens_hsa041421.31213868
37Apoptosis_Homo sapiens_hsa042101.25829561
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25426828
39Antigen processing and presentation_Homo sapiens_hsa046121.22100528
40Hepatitis C_Homo sapiens_hsa051601.18990806
41T cell receptor signaling pathway_Homo sapiens_hsa046601.16764568
42Shigellosis_Homo sapiens_hsa051311.15579047
43Viral myocarditis_Homo sapiens_hsa054161.10421707
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08284498
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05741960
46Hepatitis B_Homo sapiens_hsa051611.01771954
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89228348
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89154666
49Bladder cancer_Homo sapiens_hsa052190.81780162
50Steroid biosynthesis_Homo sapiens_hsa001000.79468220
51Amoebiasis_Homo sapiens_hsa051460.77117673
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.76634803
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75836934
54Acute myeloid leukemia_Homo sapiens_hsa052210.73219474
55Prolactin signaling pathway_Homo sapiens_hsa049170.71484216
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.60391436
57Ether lipid metabolism_Homo sapiens_hsa005650.59391941
58Dorso-ventral axis formation_Homo sapiens_hsa043200.55603208
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.55161514
60Other glycan degradation_Homo sapiens_hsa005110.54801159
61Prion diseases_Homo sapiens_hsa050200.54339049
62Collecting duct acid secretion_Homo sapiens_hsa049660.52062206
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51738656
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51040278
65Epstein-Barr virus infection_Homo sapiens_hsa051690.50407342
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49160999
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47859911
68Sphingolipid metabolism_Homo sapiens_hsa006000.47024384
69* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46283822
70Mineral absorption_Homo sapiens_hsa049780.44035573
71Pancreatic cancer_Homo sapiens_hsa052120.42962715
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.42661668
73Chronic myeloid leukemia_Homo sapiens_hsa052200.41288083
74Platelet activation_Homo sapiens_hsa046110.40851267
75Systemic lupus erythematosus_Homo sapiens_hsa053220.40131446
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.39986946
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39692421
78Small cell lung cancer_Homo sapiens_hsa052220.39457984
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38743493
80Type II diabetes mellitus_Homo sapiens_hsa049300.37455943
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37355762
82Viral carcinogenesis_Homo sapiens_hsa052030.33487810
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31495883
84HIF-1 signaling pathway_Homo sapiens_hsa040660.29399795
85Sulfur metabolism_Homo sapiens_hsa009200.28366286
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28137919
87Renal cell carcinoma_Homo sapiens_hsa052110.27223330
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26873733
89MAPK signaling pathway_Homo sapiens_hsa040100.26377717
90Insulin resistance_Homo sapiens_hsa049310.26181231
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25604571
92Notch signaling pathway_Homo sapiens_hsa043300.23895742
93Endocytosis_Homo sapiens_hsa041440.22287075
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21896644
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21673662
96Complement and coagulation cascades_Homo sapiens_hsa046100.19239841
97VEGF signaling pathway_Homo sapiens_hsa043700.18833998
98Vibrio cholerae infection_Homo sapiens_hsa051100.17593586
99Tryptophan metabolism_Homo sapiens_hsa003800.17297507
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16166367
101HTLV-I infection_Homo sapiens_hsa051660.15296460
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14984975
103MicroRNAs in cancer_Homo sapiens_hsa052060.13003811
104Ras signaling pathway_Homo sapiens_hsa040140.12693050
105Galactose metabolism_Homo sapiens_hsa000520.11022094
106FoxO signaling pathway_Homo sapiens_hsa040680.10424425
107Fructose and mannose metabolism_Homo sapiens_hsa000510.10338154
108Proteoglycans in cancer_Homo sapiens_hsa052050.09984710
109Histidine metabolism_Homo sapiens_hsa003400.09482374
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.08969705
111GnRH signaling pathway_Homo sapiens_hsa049120.07711156
112Folate biosynthesis_Homo sapiens_hsa007900.05888022

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