CD276

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)5.33726422
2polyketide metabolic process (GO:0030638)5.33726422
3doxorubicin metabolic process (GO:0044598)5.33726422
4notochord development (GO:0030903)4.95504778
5negative regulation of epidermis development (GO:0045683)4.86668347
6protein retention in ER lumen (GO:0006621)4.56912182
7heterochromatin organization (GO:0070828)4.46879256
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.37172825
9regulation of mammary gland epithelial cell proliferation (GO:0033599)4.37092017
10protein localization to kinetochore (GO:0034501)4.35747278
11dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.33915599
12negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.31337790
13bone trabecula formation (GO:0060346)4.29002774
14endodermal cell differentiation (GO:0035987)4.28160890
15regulation of telomere maintenance via telomerase (GO:0032210)4.27948463
16paraxial mesoderm development (GO:0048339)4.26949528
17basement membrane organization (GO:0071711)4.20502613
18cell adhesion mediated by integrin (GO:0033627)4.18433798
19somite rostral/caudal axis specification (GO:0032525)4.13773152
20regulation of gene silencing by RNA (GO:0060966)4.13064238
21regulation of posttranscriptional gene silencing (GO:0060147)4.13064238
22regulation of gene silencing by miRNA (GO:0060964)4.13064238
23regulation of hippo signaling (GO:0035330)3.95610943
24nuclear pore complex assembly (GO:0051292)3.94601040
25semaphorin-plexin signaling pathway (GO:0071526)3.93608960
26COPI coating of Golgi vesicle (GO:0048205)3.91789849
27Golgi transport vesicle coating (GO:0048200)3.91789849
28primitive streak formation (GO:0090009)3.91442761
29negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.88949399
30protein localization to endosome (GO:0036010)3.81328952
31regulation of nuclear cell cycle DNA replication (GO:0033262)3.81314681
32nuclear pore organization (GO:0006999)3.81011842
33pre-miRNA processing (GO:0031054)3.77580793
34histone H4-K12 acetylation (GO:0043983)3.74934897
35negative regulation of telomerase activity (GO:0051974)3.74345065
36histone H4-K8 acetylation (GO:0043982)3.63740735
37histone H4-K5 acetylation (GO:0043981)3.63740735
38polarized epithelial cell differentiation (GO:0030859)3.62967642
39skin morphogenesis (GO:0043589)3.62379590
40protein heterotrimerization (GO:0070208)3.62161448
41regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.53756124
42planar cell polarity pathway involved in neural tube closure (GO:0090179)3.52615329
43mitotic sister chromatid segregation (GO:0000070)3.51358997
44retina vasculature morphogenesis in camera-type eye (GO:0061299)3.50616022
45regulation of response to osmotic stress (GO:0047484)3.48770472
46epithelial cell-cell adhesion (GO:0090136)3.46328195
47maintenance of protein location in nucleus (GO:0051457)3.46326875
48collagen metabolic process (GO:0032963)3.46018187
49barbed-end actin filament capping (GO:0051016)3.45788655
50adhesion of symbiont to host (GO:0044406)3.45046317
51adhesion of symbiont to host cell (GO:0044650)3.44792221
52virion attachment to host cell (GO:0019062)3.44792221
53hemidesmosome assembly (GO:0031581)3.44412417
54muscle organ morphogenesis (GO:0048644)3.41943385
55substrate-dependent cell migration (GO:0006929)3.41279728
56collagen catabolic process (GO:0030574)3.39006657
57regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.37418298
58negative regulation of cell cycle G2/M phase transition (GO:1902750)3.36202795
59vascular endothelial growth factor signaling pathway (GO:0038084)3.33144913
60branching involved in mammary gland duct morphogenesis (GO:0060444)3.33095895
61DNA replication-dependent nucleosome organization (GO:0034723)3.31528299
62DNA replication-dependent nucleosome assembly (GO:0006335)3.31528299
63collagen fibril organization (GO:0030199)3.30382136
64regulation of apoptotic process involved in morphogenesis (GO:1902337)3.26800501
65positive regulation of DNA-dependent DNA replication (GO:2000105)3.26144487
66regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.25988136
67apoptotic cell clearance (GO:0043277)3.22199092
68multicellular organismal macromolecule metabolic process (GO:0044259)3.19749029
69endothelial cell morphogenesis (GO:0001886)3.18653340
70extracellular matrix disassembly (GO:0022617)3.18108681
71regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.17992855
72sister chromatid segregation (GO:0000819)3.17423615
73glial cell migration (GO:0008347)3.16553997
74establishment of apical/basal cell polarity (GO:0035089)3.14766997
75chondrocyte proliferation (GO:0035988)3.13463857
76regulation of early endosome to late endosome transport (GO:2000641)3.13310753
77wound healing, spreading of epidermal cells (GO:0035313)3.12311969
78heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.11122783
79ganglion development (GO:0061548)3.10948380
80aminoglycoside antibiotic metabolic process (GO:0030647)3.10863445
81rRNA transcription (GO:0009303)3.09388527
82chromatin assembly (GO:0031497)3.08054644
83multicellular organismal catabolic process (GO:0044243)3.04219796
84cell migration involved in sprouting angiogenesis (GO:0002042)3.02567380
85tooth mineralization (GO:0034505)3.02412125
86protein localization to chromosome, centromeric region (GO:0071459)3.01480426
87branching involved in salivary gland morphogenesis (GO:0060445)3.01351347
88negative regulation of epidermal cell differentiation (GO:0045605)3.01312753
89adherens junction assembly (GO:0034333)3.01008445
90histone arginine methylation (GO:0034969)3.00362571
91cell-substrate junction assembly (GO:0007044)3.00101798
92anterior/posterior axis specification, embryo (GO:0008595)2.98456461
93negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.97929670
94axon extension (GO:0048675)2.97502429
95RNA stabilization (GO:0043489)2.97138683
96mRNA stabilization (GO:0048255)2.97138683
97multicellular organismal metabolic process (GO:0044236)2.95751898
98formation of translation preinitiation complex (GO:0001731)2.95345140
99cell fate commitment involved in formation of primary germ layer (GO:0060795)2.94654378
100anterior/posterior axis specification (GO:0009948)2.94182647
101embryonic camera-type eye development (GO:0031076)2.93325612
102vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.91353375
103endothelial cell chemotaxis (GO:0035767)2.90627383
104maternal placenta development (GO:0001893)2.89213571
105cell proliferation involved in metanephros development (GO:0072203)2.88804436
106hippo signaling (GO:0035329)2.88702122
107DNA unwinding involved in DNA replication (GO:0006268)2.85930633
108cell migration involved in gastrulation (GO:0042074)2.85818848
109peptidyl-arginine omega-N-methylation (GO:0035247)2.84705965
110positive regulation of smoothened signaling pathway (GO:0045880)2.83588641
111negative regulation of axon extension involved in axon guidance (GO:0048843)2.82027024
112pore complex assembly (GO:0046931)2.81846272
113signal transduction involved in regulation of gene expression (GO:0023019)2.80706972
114cell-cell junction maintenance (GO:0045217)2.80388376
115intracellular estrogen receptor signaling pathway (GO:0030520)2.80384990
116regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.80147982
117G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.80105002
118establishment or maintenance of monopolar cell polarity (GO:0061339)2.74840464
119establishment of monopolar cell polarity (GO:0061162)2.74840464
120positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.74152940
121negative regulation of telomere maintenance (GO:0032205)2.73121415
122negative regulation of chondrocyte differentiation (GO:0032331)2.72662618
123negative regulation of smoothened signaling pathway (GO:0045879)2.71157020
124convergent extension (GO:0060026)2.71153035
125positive regulation of SMAD protein import into nucleus (GO:0060391)2.70961644
126Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.70629715
127intestinal epithelial cell development (GO:0060576)2.69030296
128wound healing, spreading of cells (GO:0044319)2.68411546
129trophectodermal cell differentiation (GO:0001829)2.67919184
130craniofacial suture morphogenesis (GO:0097094)2.66434655
131axon extension involved in axon guidance (GO:0048846)2.65258333
132neuron projection extension involved in neuron projection guidance (GO:1902284)2.65258333
133heparan sulfate proteoglycan metabolic process (GO:0030201)2.65062584
134regulation of establishment of planar polarity (GO:0090175)2.64943941
135NLS-bearing protein import into nucleus (GO:0006607)2.63937584
136histone H4-K16 acetylation (GO:0043984)2.63825483
137negative regulation of focal adhesion assembly (GO:0051895)2.63440934
138negative regulation of cell junction assembly (GO:1901889)2.63440934
139negative regulation of adherens junction organization (GO:1903392)2.63440934
140bone morphogenesis (GO:0060349)2.63397482
141stress fiber assembly (GO:0043149)2.62183720
142regulation of SMAD protein import into nucleus (GO:0060390)2.61286111
143non-canonical Wnt signaling pathway (GO:0035567)2.60663163
144maintenance of protein localization in organelle (GO:0072595)2.60625462
145regulation of translation in response to stress (GO:0043555)2.60430266
146positive regulation of axon extension (GO:0045773)2.60074137
147epithelial cell differentiation involved in prostate gland development (GO:0060742)2.59865271
148retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59710383
149lateral sprouting from an epithelium (GO:0060601)2.58463408
150DNA duplex unwinding (GO:0032508)2.57494572
151blood vessel endothelial cell migration (GO:0043534)2.56672789
152cullin deneddylation (GO:0010388)2.56178006
153regulation of axon extension involved in axon guidance (GO:0048841)2.55931506
154hyaluronan catabolic process (GO:0030214)2.55900356
155DNA geometric change (GO:0032392)2.55127309
156cochlea morphogenesis (GO:0090103)2.54809487
157neuron projection extension (GO:1990138)2.54577215
158regulation of stem cell maintenance (GO:2000036)2.53879107
159positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.53692154
160cell migration involved in heart development (GO:0060973)2.53641853
161mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.53227106
162regulation of telomere maintenance (GO:0032204)2.52703892
163peptidyl-arginine methylation (GO:0018216)2.51557382
164peptidyl-arginine N-methylation (GO:0035246)2.51557382
165skeletal muscle organ development (GO:0060538)2.51172645
166embryonic axis specification (GO:0000578)2.50390007
167diaphragm development (GO:0060539)2.50282817
168cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.49700773
169focal adhesion assembly (GO:0048041)2.49225228
170cell-substrate adherens junction assembly (GO:0007045)2.49225228
171decidualization (GO:0046697)2.49142088
172cytoskeletal anchoring at plasma membrane (GO:0007016)2.45942599
173negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.45217087
174amyloid precursor protein catabolic process (GO:0042987)2.44990254
175peptidyl-proline hydroxylation (GO:0019511)2.44386707
176extracellular matrix organization (GO:0030198)2.40204324
177chondrocyte development (GO:0002063)2.39452566
178extracellular structure organization (GO:0043062)2.39203323
179membrane protein ectodomain proteolysis (GO:0006509)2.38847003
180cellular response to vitamin (GO:0071295)2.38252398
181protein maturation by protein folding (GO:0022417)2.37927125
182negative regulation of axon guidance (GO:1902668)2.37210377
183gap junction assembly (GO:0016264)2.36615495
184camera-type eye morphogenesis (GO:0048593)2.34644138
185embryo implantation (GO:0007566)2.34527741
186regulation of membrane protein ectodomain proteolysis (GO:0051043)2.34486501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.01462225
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.01462225
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.01462225
4E2F7_22180533_ChIP-Seq_HELA_Human4.07747918
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.44160349
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.02809967
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.01600659
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.95209274
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.92381601
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.82185376
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.79357423
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.73718176
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71832071
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.71316428
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.62021777
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.54812215
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.53722027
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.52368805
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.50708336
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.50573953
21CLOCK_20551151_ChIP-Seq_293T_Human2.39394168
22TCF3_18692474_ChIP-Seq_MESCs_Mouse2.30841347
23LXR_22292898_ChIP-Seq_THP-1_Human2.25957307
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.25248354
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22872758
26ZFP281_18757296_ChIP-ChIP_E14_Mouse2.20609732
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.20147867
28HIF1A_21447827_ChIP-Seq_MCF-7_Human2.19339428
29ZNF263_19887448_ChIP-Seq_K562_Human2.14061875
30ERG_21242973_ChIP-ChIP_JURKAT_Human2.08061078
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05181660
32E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00432095
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.99039774
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96722089
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.94636397
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93526729
37NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.91998423
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89238545
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89092038
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.88217491
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.82783774
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.81553132
43* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.76871451
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75430287
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75366740
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.74521510
47POU5F1_16518401_ChIP-PET_MESCs_Mouse1.67893227
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65670358
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.64268107
50NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.62669315
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60889243
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57911773
53TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.57355299
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.57005359
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55877519
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55668799
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55363596
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52348987
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49908475
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42280728
61UBF1/2_26484160_Chip-Seq_HMECs_Human1.40471086
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39740131
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38384191
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.37941093
65MYC_22102868_ChIP-Seq_BL_Human1.37445956
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.36323332
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34308915
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33090588
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.32486253
70OCT4_18692474_ChIP-Seq_MEFs_Mouse1.31547267
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.31158795
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30371854
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30127060
74PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.29999075
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29410346
76* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29294589
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.27938521
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27615215
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26962794
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.26789010
81* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26318565
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25307463
83SOX2_18692474_ChIP-Seq_MEFs_Mouse1.25221220
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24976143
85NANOG_18692474_ChIP-Seq_MEFs_Mouse1.24135346
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24042689
87RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23297008
88EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23297008
89TP53_22127205_ChIP-Seq_IMR90_Human1.22590047
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20416146
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20354186
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19993714
93SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19853527
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19714182
95KDM2B_26808549_Chip-Seq_DND41_Human1.19224326
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18932663
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18868453
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18705047
99NANOG_18692474_ChIP-Seq_MESCs_Mouse1.18121747
100TET1_21451524_ChIP-Seq_MESCs_Mouse1.17260127
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17095730
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16281200
103POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15806595
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15598800
105AR_21909140_ChIP-Seq_LNCAP_Human1.13542933
106TET1_21490601_ChIP-Seq_MESCs_Mouse1.13438159
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13365485
108EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13106471
109SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12351486
110SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11499469
111POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08688548
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08673371
113TP53_23651856_ChIP-Seq_MEFs_Mouse1.06333727
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06189073
115SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06036042
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05660899
117XRN2_22483619_ChIP-Seq_HELA_Human1.05611236
118NANOG_16518401_ChIP-PET_MESCs_Mouse1.05263502
119NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05034849
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04614237
121CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03378751
122STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01181790
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00650476
124CDX2_20551321_ChIP-Seq_CACO-2_Human1.00165181
125SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00044628
126* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99767544
127KDM2B_26808549_Chip-Seq_K562_Human0.99673452
128RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99123995
129KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98994727
130RACK7_27058665_Chip-Seq_MCF-7_Human0.97993370
131ISL1_27105846_Chip-Seq_CPCs_Mouse0.97710355
132* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96321471
133CTCF_27219007_Chip-Seq_Bcells_Human0.95216207
134TBX20_22080862_ChIP-Seq_HEART_Mouse0.94837580
135TBX20_22328084_ChIP-Seq_HEART_Mouse0.94837580
136ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93998031
137SA1_27219007_Chip-Seq_ERYTHROID_Human0.93754829
138SOX2_16153702_ChIP-ChIP_HESCs_Human0.92572092
139CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92443041
140SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92365666
141RING1B_27294783_Chip-Seq_NPCs_Mouse0.92306300
142SMC4_20622854_ChIP-Seq_HELA_Human0.91959574
143ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91480316
144POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91467798
145* KDM2B_26808549_Chip-Seq_JURKAT_Human0.91385312
146* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91377228
147SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91367854
148SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91367854
149CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90724873
150E2F1_17053090_ChIP-ChIP_MCF-7_Human0.90524262
151DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90385561
152E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90352686
153FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90273570
154EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89938907
155WT1_19549856_ChIP-ChIP_CCG9911_Human0.89702156
156NCOR1_26117541_ChIP-Seq_K562_Human0.88064758
157TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87422014
158* ATF3_27146783_Chip-Seq_COLON_Human0.87376500
159CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86966293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.78369189
2MP0003122_maternal_imprinting3.41776729
3MP0003705_abnormal_hypodermis_morpholog3.37441333
4MP0005058_abnormal_lysosome_morphology2.81914436
5MP0005257_abnormal_intraocular_pressure2.78097092
6MP0003890_abnormal_embryonic-extraembry2.66616159
7MP0003121_genomic_imprinting2.39495039
8MP0004264_abnormal_extraembryonic_tissu2.33947566
9MP0008438_abnormal_cutaneous_collagen2.31273079
10MP0003123_paternal_imprinting2.29007545
11MP0009840_abnormal_foam_cell2.22005867
12MP0010352_gastrointestinal_tract_polyps2.16297615
13MP0003283_abnormal_digestive_organ2.10668836
14MP0000049_abnormal_middle_ear2.07017805
15MP0004858_abnormal_nervous_system2.01900470
16MP0009384_cardiac_valve_regurgitation2.00907171
17MP0004957_abnormal_blastocyst_morpholog1.95830620
18MP0006292_abnormal_olfactory_placode1.93152536
19MP0002877_abnormal_melanocyte_morpholog1.92196780
20MP0001849_ear_inflammation1.91147035
21MP0001958_emphysema1.88894807
22MP0004272_abnormal_basement_membrane1.87843444
23MP0006054_spinal_hemorrhage1.86954914
24MP0002932_abnormal_joint_morphology1.83327109
25MP0003119_abnormal_digestive_system1.80674031
26MP0000428_abnormal_craniofacial_morphol1.78919546
27MP0001293_anophthalmia1.78190181
28MP0002653_abnormal_ependyma_morphology1.76214586
29MP0004233_abnormal_muscle_weight1.74328089
30MP0005394_taste/olfaction_phenotype1.73450914
31MP0005499_abnormal_olfactory_system1.73450914
32MP0009053_abnormal_anal_canal1.72858296
33MP0002254_reproductive_system_inflammat1.72805263
34MP0000566_synostosis1.67395846
35MP0005623_abnormal_meninges_morphology1.67193592
36MP0003011_delayed_dark_adaptation1.66787162
37MP0005508_abnormal_skeleton_morphology1.66244024
38MP0005380_embryogenesis_phenotype1.65315544
39MP0001672_abnormal_embryogenesis/_devel1.65315544
40MP0005503_abnormal_tendon_morphology1.64464086
41MP0000767_abnormal_smooth_muscle1.64251372
42MP0003942_abnormal_urinary_system1.63567504
43MP0000762_abnormal_tongue_morphology1.63542353
44MP0000678_abnormal_parathyroid_gland1.63332883
45MP0003755_abnormal_palate_morphology1.61856768
46MP0002249_abnormal_larynx_morphology1.60139997
47MP0004133_heterotaxia1.58770389
48MP0002088_abnormal_embryonic_growth/wei1.58567754
49MP0003984_embryonic_growth_retardation1.58502420
50MP0000537_abnormal_urethra_morphology1.58419629
51MP0003937_abnormal_limbs/digits/tail_de1.55128281
52MP0004197_abnormal_fetal_growth/weight/1.54481751
53MP0002085_abnormal_embryonic_tissue1.53922078
54MP0002084_abnormal_developmental_patter1.53186109
55MP0002233_abnormal_nose_morphology1.53016771
56MP0002896_abnormal_bone_mineralization1.51390226
57MP0003385_abnormal_body_wall1.47587225
58MP0003935_abnormal_craniofacial_develop1.46990064
59MP0005275_abnormal_skin_tensile1.45443379
60MP0002060_abnormal_skin_morphology1.43343479
61MP0001542_abnormal_bone_strength1.42388211
62MP0000350_abnormal_cell_proliferation1.41513211
63MP0002092_abnormal_eye_morphology1.39691176
64MP0009250_abnormal_appendicular_skeleto1.39414605
65MP0005197_abnormal_uvea_morphology1.39115581
66MP0000432_abnormal_head_morphology1.37466816
67MP0002116_abnormal_craniofacial_bone1.32326339
68MP0000579_abnormal_nail_morphology1.32191571
69MP0002089_abnormal_postnatal_growth/wei1.31351655
70MP0003329_amyloid_beta_deposits1.29788902
71MP0002086_abnormal_extraembryonic_tissu1.29123323
72MP0003453_abnormal_keratinocyte_physiol1.27857218
73MP0005023_abnormal_wound_healing1.27201758
74MP0005248_abnormal_Harderian_gland1.26928978
75MP0003566_abnormal_cell_adhesion1.26697225
76MP0003938_abnormal_ear_development1.25527650
77MP0000751_myopathy1.25404816
78MP0003077_abnormal_cell_cycle1.25325411
79MP0000534_abnormal_ureter_morphology1.24372421
80MP0005409_darkened_coat_color1.23564033
81MP0003279_aneurysm1.22758207
82MP0002111_abnormal_tail_morphology1.21551061
83MP0001730_embryonic_growth_arrest1.20072412
84MP0003115_abnormal_respiratory_system1.18713021
85MP0002114_abnormal_axial_skeleton1.18252338
86MP0001915_intracranial_hemorrhage1.18062835
87MP0008007_abnormal_cellular_replicative1.18024685
88MP0001697_abnormal_embryo_size1.17242997
89MP0008932_abnormal_embryonic_tissue1.17156970
90MP0008057_abnormal_DNA_replication1.17031930
91MP0002697_abnormal_eye_size1.13730334
92MP0002295_abnormal_pulmonary_circulatio1.13269712
93MP0002925_abnormal_cardiovascular_devel1.13110195
94MP0003941_abnormal_skin_development1.13078742
95MP0005076_abnormal_cell_differentiation1.13015194
96MP0008789_abnormal_olfactory_epithelium1.11734827
97MP0000604_amyloidosis1.11074653
98MP0000163_abnormal_cartilage_morphology1.10435652
99MP0005595_abnormal_vascular_smooth1.09239742
100MP0002127_abnormal_cardiovascular_syste1.06772128
101MP0003634_abnormal_glial_cell1.06171197
102MP0002751_abnormal_autonomic_nervous1.05719851
103MP0001286_abnormal_eye_development1.04287314
104MP0003111_abnormal_nucleus_morphology1.03767191
105MP0003172_abnormal_lysosome_physiology1.03720551
106MP0002332_abnormal_exercise_endurance1.03360821
107MP0004510_myositis1.02614593
108MP0000733_abnormal_muscle_development0.99389635
109MP0002109_abnormal_limb_morphology0.99066206
110MP0010368_abnormal_lymphatic_system0.98481174
111MP0009703_decreased_birth_body0.95556385
112MP0001243_abnormal_dermal_layer0.95384034
113MP0003315_abnormal_perineum_morphology0.94705122
114MP0005193_abnormal_anterior_eye0.94605066
115MP0000462_abnormal_digestive_system0.93600694
116MP0005171_absent_coat_pigmentation0.93590434
117MP0002080_prenatal_lethality0.93421006
118MP0002282_abnormal_trachea_morphology0.92987564
119MP0001879_abnormal_lymphatic_vessel0.92808122
120MP0000343_altered_response_to0.92025307
121MP0000750_abnormal_muscle_regeneration0.91091162
122MP0003861_abnormal_nervous_system0.91025989
123MP0008961_abnormal_basal_metabolism0.89882583
124MP0001348_abnormal_lacrimal_gland0.88614735
125MP0002938_white_spotting0.87150690
126MP0005451_abnormal_body_composition0.84906854
127MP0001614_abnormal_blood_vessel0.84889426
128MP0002998_abnormal_bone_remodeling0.84282960
129MP0002113_abnormal_skeleton_development0.83545820
130MP0002081_perinatal_lethality0.83019425
131MP0000516_abnormal_urinary_system0.80590144
132MP0005367_renal/urinary_system_phenotyp0.80590144
133MP0000467_abnormal_esophagus_morphology0.79009459
134MP0002108_abnormal_muscle_morphology0.78490252
135MP0000778_abnormal_nervous_system0.78322535
136MP0009672_abnormal_birth_weight0.77640848
137MP0005390_skeleton_phenotype0.76446808
138MP0000003_abnormal_adipose_tissue0.75760576
139MP0003091_abnormal_cell_migration0.73060870
140MP0001299_abnormal_eye_distance/0.72748688
141MP0003448_altered_tumor_morphology0.72636671
142MP0002115_abnormal_skeleton_extremities0.69085924
143MP0000858_altered_metastatic_potential0.66849064
144MP0008260_abnormal_autophagy0.66447061
145MP0002796_impaired_skin_barrier0.66152244
146MP0000538_abnormal_urinary_bladder0.63279028

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.02855113
2Hepatoblastoma (HP:0002884)4.47854539
3Protrusio acetabuli (HP:0003179)4.32322876
4Vertebral compression fractures (HP:0002953)3.42035211
5Rib fusion (HP:0000902)3.34157825
6Abnormality of glycolipid metabolism (HP:0010969)3.21509852
7Abnormality of liposaccharide metabolism (HP:0010968)3.21509852
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.21509852
9Ependymoma (HP:0002888)3.16081397
10Renal duplication (HP:0000075)3.11825540
11Hyperacusis (HP:0010780)3.11285872
12Multiple enchondromatosis (HP:0005701)3.07762266
13Spinal rigidity (HP:0003306)3.05443739
14Cerebral aneurysm (HP:0004944)3.04256072
15Premature rupture of membranes (HP:0001788)3.02460046
16Abnormality of the lower motor neuron (HP:0002366)3.01673933
17Neonatal short-limb short stature (HP:0008921)2.92511782
18Partial duplication of the phalanx of hand (HP:0009999)2.85997980
19Fused cervical vertebrae (HP:0002949)2.79134875
20Partial duplication of thumb phalanx (HP:0009944)2.74670835
21Fragile skin (HP:0001030)2.72296771
22Trismus (HP:0000211)2.71908552
23Aortic dissection (HP:0002647)2.70932993
24Bifid tongue (HP:0010297)2.67240888
25Broad metatarsal (HP:0001783)2.64315031
26Vascular tortuosity (HP:0004948)2.63053018
27Short humerus (HP:0005792)2.61937859
28Natal tooth (HP:0000695)2.60560901
29Astrocytoma (HP:0009592)2.59615825
30Abnormality of the astrocytes (HP:0100707)2.59615825
31Aplasia/hypoplasia of the humerus (HP:0006507)2.55870257
32Nuclear cataract (HP:0100018)2.53968216
33Arterial tortuosity (HP:0005116)2.51901681
34Shallow orbits (HP:0000586)2.50438736
35Increased connective tissue (HP:0009025)2.49492419
36Neoplasm of striated muscle (HP:0009728)2.48543287
37Short nail (HP:0001799)2.46980092
38Short 5th finger (HP:0009237)2.46091719
39Abnormality of the distal phalanx of the thumb (HP:0009617)2.43912974
40Nephroblastoma (Wilms tumor) (HP:0002667)2.42125601
41Wormian bones (HP:0002645)2.40532383
42Hypochromic microcytic anemia (HP:0004840)2.39407661
43Turricephaly (HP:0000262)2.36513097
44Embryonal renal neoplasm (HP:0011794)2.34090122
45Rectal fistula (HP:0100590)2.30743947
46Rectovaginal fistula (HP:0000143)2.30743947
47Neurofibrillary tangles (HP:0002185)2.30276835
48Achilles tendon contracture (HP:0001771)2.29789017
49Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.29635094
50Short 4th metacarpal (HP:0010044)2.29237361
51Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29237361
52Preauricular skin tag (HP:0000384)2.27700953
53Disproportionate tall stature (HP:0001519)2.27096229
54Shawl scrotum (HP:0000049)2.25981518
55Missing ribs (HP:0000921)2.25972548
56Thin bony cortex (HP:0002753)2.25539048
57Dysostosis multiplex (HP:0000943)2.24851987
58Selective tooth agenesis (HP:0001592)2.23395858
59Preaxial foot polydactyly (HP:0001841)2.22422452
60Abnormality of the phalanges of the hallux (HP:0010057)2.22233970
61Mildly elevated creatine phosphokinase (HP:0008180)2.19524049
62Mitral regurgitation (HP:0001653)2.16794796
63Abnormality of the pubic bones (HP:0003172)2.16477526
64Rhabdomyosarcoma (HP:0002859)2.16289698
65Biconcave vertebral bodies (HP:0004586)2.16012755
66Bowel diverticulosis (HP:0005222)2.13346855
67Follicular hyperkeratosis (HP:0007502)2.12219790
68Ankle contracture (HP:0006466)2.11575951
69Broad thumb (HP:0011304)2.10681828
70Skin tags (HP:0010609)2.08971354
71Peritonitis (HP:0002586)2.08369219
72Atresia of the external auditory canal (HP:0000413)2.08228276
73Abnormality of the salivary glands (HP:0010286)2.08039626
74Long toe (HP:0010511)2.07671600
75Intestinal fistula (HP:0100819)2.06295801
76Genu recurvatum (HP:0002816)2.06095828
77Congenital glaucoma (HP:0001087)2.05467974
78Joint laxity (HP:0001388)2.04491321
79Urinary glycosaminoglycan excretion (HP:0003541)2.04338558
80Mucopolysacchariduria (HP:0008155)2.04338558
81Abnormal lung lobation (HP:0002101)2.03367118
82Cerebral inclusion bodies (HP:0100314)2.02589774
83Overriding aorta (HP:0002623)2.01875858
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00353214
85Abnormality of polysaccharide metabolism (HP:0011012)2.00353214
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00353214
87Mesomelia (HP:0003027)2.00341320
88Glioma (HP:0009733)1.99760358
89Hand muscle atrophy (HP:0009130)1.99398969
90Abnormality of the distal phalanges of the toes (HP:0010182)1.99210992
91Abnormality of the Achilles tendon (HP:0005109)1.98658553
92Hyperextensible skin (HP:0000974)1.98302364
93Vaginal fistula (HP:0004320)1.97178707
94Increased nuchal translucency (HP:0010880)1.97119445
95Insomnia (HP:0100785)1.96982304
96J-shaped sella turcica (HP:0002680)1.95893449
97Elfin facies (HP:0004428)1.95867439
98Mitral valve prolapse (HP:0001634)1.95796252
99Aplasia/Hypoplasia of the sternum (HP:0006714)1.95579931
100Preauricular pit (HP:0004467)1.95551791
101Periauricular skin pits (HP:0100277)1.95551791
102Broad toe (HP:0001837)1.94841759
103Abnormality of the acetabulum (HP:0003170)1.94299827
104Axonal loss (HP:0003447)1.93699835
105Vertebral fusion (HP:0002948)1.93182534
106Abnormality of the musculature of the hand (HP:0001421)1.93157012
107Aortic aneurysm (HP:0004942)1.92046126
108Vacuolated lymphocytes (HP:0001922)1.91963407
109Abnormality of dentin (HP:0010299)1.90930548
110Buphthalmos (HP:0000557)1.90737858
111Neoplasm of the heart (HP:0100544)1.90313835
112Arnold-Chiari malformation (HP:0002308)1.90161069
113Wide anterior fontanel (HP:0000260)1.90006867
114Atrophic scars (HP:0001075)1.89891886
115Increased cerebral lipofuscin (HP:0011813)1.89563449
116Abnormal cartilage morphology (HP:0002763)1.88652121
117Elbow flexion contracture (HP:0002987)1.87634111
118Hypoventilation (HP:0002791)1.87518492
119Advanced eruption of teeth (HP:0006288)1.87153185
120Bladder diverticulum (HP:0000015)1.85899614
121Lymphangioma (HP:0100764)1.85441183
122Glossoptosis (HP:0000162)1.83990806
123Renovascular hypertension (HP:0100817)1.82358075
124Abnormality of the 4th metacarpal (HP:0010012)1.82068695
125Increased variability in muscle fiber diameter (HP:0003557)1.81870441
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.81789133
127Osteolytic defects of the hand bones (HP:0009699)1.81789133
128Cervical subluxation (HP:0003308)1.81387659
129Distal upper limb amyotrophy (HP:0007149)1.81387604
130Upper limb amyotrophy (HP:0009129)1.81387604
131Long palpebral fissure (HP:0000637)1.81244641
132Joint stiffness (HP:0001387)1.80914277
133Myocardial infarction (HP:0001658)1.80190012
134Leiomyosarcoma (HP:0100243)1.79966601
135Uterine leiomyosarcoma (HP:0002891)1.79966601
136Wrist flexion contracture (HP:0001239)1.79531194
137Generalized amyotrophy (HP:0003700)1.79485662
138Flat cornea (HP:0007720)1.79250962
139Hallux valgus (HP:0001822)1.78994393
140Facial cleft (HP:0002006)1.78554237
141Flat acetabular roof (HP:0003180)1.78255067
142Soft skin (HP:0000977)1.77631770
143Coronal craniosynostosis (HP:0004440)1.77011624
144Aplasia/Hypoplasia of the scapulae (HP:0006713)1.76972542
145Hypoplastic scapulae (HP:0000882)1.76972542
146Spondylolisthesis (HP:0003302)1.75075460
147Asymmetry of the thorax (HP:0001555)1.74478979
148Large earlobe (HP:0009748)1.74269966
149Pseudobulbar signs (HP:0002200)1.73958461
150Pterygium (HP:0001059)1.71733547
151Broad phalanges of the hand (HP:0009768)1.70036602
152Protruding ear (HP:0000411)1.69266818
153Blue sclerae (HP:0000592)1.69146777
154Slender build (HP:0001533)1.68382023
155Loss of speech (HP:0002371)1.68259863
156Nasolacrimal duct obstruction (HP:0000579)1.67382316
157Absent frontal sinuses (HP:0002688)1.67129270
158Cupped ribs (HP:0000887)1.66523631
159Deviation of the hallux (HP:0010051)1.66305209
160Supernumerary spleens (HP:0009799)1.66254168
161Mitral stenosis (HP:0001718)1.65879817
162Medulloblastoma (HP:0002885)1.65491601
163Dislocated radial head (HP:0003083)1.64915465
164Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64683898
165Abnormal delivery (HP:0001787)1.64570651
166Broad long bones (HP:0005622)1.63824395
167Ulnar bowing (HP:0003031)1.63702173
168Generalized hypotonia (HP:0001290)1.63339059
169Ectopia lentis (HP:0001083)1.63309449
170Type 1 muscle fiber predominance (HP:0003803)1.62901035
171Inguinal hernia (HP:0000023)1.62764081
172Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62351002
173Amyotrophic lateral sclerosis (HP:0007354)1.62316299
174Malignant gastrointestinal tract tumors (HP:0006749)1.62279681
175Gastrointestinal carcinoma (HP:0002672)1.62279681
176Abnormality of the radial head (HP:0003995)1.61522680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.20755386
2ERN13.91951896
3IRAK33.10349914
4GRK52.81130102
5MAP3K102.65583727
6NME22.64179351
7TYRO32.55776370
8EPHA22.34501214
9TTK2.24735539
10SMG12.24111693
11DDR22.23139158
12GRK62.19372785
13PDGFRA2.16980100
14LATS22.16958302
15PAK41.98317072
16TGFBR21.93076029
17EEF2K1.89629569
18BUB11.85285571
19LATS11.70229256
20STK101.61294491
21TRIB31.61134468
22CAMK1D1.58813053
23CDK71.52468848
24CSF1R1.50010557
25GRK11.46989346
26TIE11.45803836
27MOS1.45175839
28EPHB21.41517545
29PTK21.41438930
30PIM21.40695710
31MATK1.40603697
32MAPK71.38967354
33RPS6KA21.38955525
34ARAF1.35044349
35CAMK1G1.33674366
36ADRBK21.30482707
37ERBB41.26146663
38FGFR31.25775398
39MTOR1.23303046
40NTRK11.19757883
41CHEK21.19656447
42FGFR11.19137116
43ABL21.16602856
44FGFR41.16274066
45PKN21.15712990
46PLK11.14973009
47LMTK21.10590314
48GRK71.08888787
49TTN1.08846112
50PRKG21.06749426
51BRSK21.05113810
52CDC71.04169485
53NEK91.03392967
54SIK11.03252169
55CAMK40.96803894
56PRKD20.96606929
57NEK20.95262740
58RIPK10.87589683
59AKT20.86636515
60ICK0.86396908
61MAP3K30.85487618
62BMX0.85060666
63WNK10.84842582
64ADRBK10.84533283
65CHEK10.84027458
66PASK0.82895301
67STK38L0.82322776
68ALK0.81969111
69MYLK0.81724637
70ERBB20.80842352
71PAK20.79586742
72NEK10.79379663
73TAOK10.76002139
74RPS6KB20.75316717
75DAPK30.75109834
76ROCK20.71698209
77KDR0.71641975
78MAP3K110.69037093
79AURKA0.68109574
80MET0.68076695
81BRD40.67336517
82BRSK10.67042939
83RPS6KC10.66224441
84RPS6KL10.66224441
85ILK0.65988779
86BRAF0.65090925
87MARK20.63861591
88MST1R0.63437389
89PTK60.62581176
90CDK20.60133369
91HIPK20.60093324
92CDK80.59853785
93PAK30.59705392
94PRKCI0.59119337
95DMPK0.58512110
96EPHB10.57987274
97KSR10.54690197
98PRKD30.53793233
99CSNK1A1L0.53774975
100CSNK1G30.52739170
101DYRK1B0.51459350
102TESK10.51310800
103DYRK20.50879556
104STK30.50860382
105AURKB0.50384600
106MAP3K90.49690764
107PRPF4B0.48298782
108PAK10.48172069
109ROCK10.47777335
110FER0.47048133
111DYRK30.46625802
112CDK40.45906505
113RPS6KA60.45298040
114TESK20.45032192
115MARK10.44683550
116SIK30.43599680
117ATM0.43253946
118CSNK1E0.43109707
119GSK3A0.42331833
120CDK180.42303446
121CDK150.40198585
122ATR0.39416845
123PLK30.38509173
124CHUK0.38292663
125TAOK20.38171578
126CDK10.37796002
127PDGFRB0.37457843
128AKT30.36850873
129LIMK10.36815429
130RPS6KA40.36768761
131CDK140.36423444
132MAP3K80.36342084
133MAP3K60.36224854
134CDK11A0.35234958
135CDC42BPA0.34895066
136TGFBR10.34765989
137SRC0.34177283
138CAMK2G0.33631835
139IGF1R0.33283025
140MAPK10.33143875
141ERBB30.33048414
142FLT30.32955648
143CDK90.29622674
144CLK10.29150741
145CDK60.29037776
146CSNK1G20.28142695
147CSNK1G10.27622769
148STK380.27222295
149PAK60.25037373

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.21142167
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.01284770
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92092491
4Other glycan degradation_Homo sapiens_hsa005112.89886355
5Hedgehog signaling pathway_Homo sapiens_hsa043402.58721461
6Lysosome_Homo sapiens_hsa041422.51923999
7Hippo signaling pathway_Homo sapiens_hsa043902.50480711
8RNA transport_Homo sapiens_hsa030132.37815976
9Vitamin B6 metabolism_Homo sapiens_hsa007502.33348865
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.22238427
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.18812460
12Cell cycle_Homo sapiens_hsa041102.09504448
13Adherens junction_Homo sapiens_hsa045202.08709293
14MicroRNAs in cancer_Homo sapiens_hsa052062.01958415
15Bladder cancer_Homo sapiens_hsa052191.96113423
16ECM-receptor interaction_Homo sapiens_hsa045121.88130498
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88036845
18Notch signaling pathway_Homo sapiens_hsa043301.84447187
19mRNA surveillance pathway_Homo sapiens_hsa030151.84172034
20Prion diseases_Homo sapiens_hsa050201.82073200
21Thyroid cancer_Homo sapiens_hsa052161.80439634
22Vibrio cholerae infection_Homo sapiens_hsa051101.77668337
23Proteoglycans in cancer_Homo sapiens_hsa052051.75243527
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.74493963
25Fructose and mannose metabolism_Homo sapiens_hsa000511.73417436
26Steroid biosynthesis_Homo sapiens_hsa001001.67862164
27Spliceosome_Homo sapiens_hsa030401.67744886
28Galactose metabolism_Homo sapiens_hsa000521.61148488
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.60535570
30DNA replication_Homo sapiens_hsa030301.58177294
31Wnt signaling pathway_Homo sapiens_hsa043101.58110658
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.56037713
33Focal adhesion_Homo sapiens_hsa045101.55893397
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.47448556
35TGF-beta signaling pathway_Homo sapiens_hsa043501.45379660
36p53 signaling pathway_Homo sapiens_hsa041151.43881945
37One carbon pool by folate_Homo sapiens_hsa006701.43600231
38mTOR signaling pathway_Homo sapiens_hsa041501.42182976
39Pathways in cancer_Homo sapiens_hsa052001.35046729
40Mismatch repair_Homo sapiens_hsa034301.29282411
41Tight junction_Homo sapiens_hsa045301.27755113
42Small cell lung cancer_Homo sapiens_hsa052221.23181291
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21302113
44Protein digestion and absorption_Homo sapiens_hsa049741.14865931
45Colorectal cancer_Homo sapiens_hsa052101.14447687
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11312406
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08897781
48Dilated cardiomyopathy_Homo sapiens_hsa054141.06530085
49PI3K-Akt signaling pathway_Homo sapiens_hsa041511.06110621
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06080216
51Salmonella infection_Homo sapiens_hsa051321.06005679
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05545537
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04480197
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04031245
55Pentose phosphate pathway_Homo sapiens_hsa000301.03796100
56HTLV-I infection_Homo sapiens_hsa051661.03734788
57Rap1 signaling pathway_Homo sapiens_hsa040151.02964690
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02606292
59RNA degradation_Homo sapiens_hsa030181.00841480
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00648468
61Fanconi anemia pathway_Homo sapiens_hsa034600.97939226
62Arachidonic acid metabolism_Homo sapiens_hsa005900.97584865
63Endometrial cancer_Homo sapiens_hsa052130.95872981
64Sphingolipid metabolism_Homo sapiens_hsa006000.94687970
65Axon guidance_Homo sapiens_hsa043600.92882643
66Base excision repair_Homo sapiens_hsa034100.91932666
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91302260
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90508493
69N-Glycan biosynthesis_Homo sapiens_hsa005100.88796621
70Chronic myeloid leukemia_Homo sapiens_hsa052200.88652287
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87040801
72Sulfur relay system_Homo sapiens_hsa041220.86426229
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86191342
74Melanoma_Homo sapiens_hsa052180.83456018
75Melanogenesis_Homo sapiens_hsa049160.79327388
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79084635
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75692097
78Nucleotide excision repair_Homo sapiens_hsa034200.75190154
79Shigellosis_Homo sapiens_hsa051310.73827986
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.73795760
81RNA polymerase_Homo sapiens_hsa030200.72598166
82Viral carcinogenesis_Homo sapiens_hsa052030.71453897
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.70433268
84Phagosome_Homo sapiens_hsa041450.68904739
85Non-small cell lung cancer_Homo sapiens_hsa052230.68758122
86Complement and coagulation cascades_Homo sapiens_hsa046100.68480130
87Malaria_Homo sapiens_hsa051440.67286711
88Pancreatic cancer_Homo sapiens_hsa052120.66492253
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66314948
90Insulin signaling pathway_Homo sapiens_hsa049100.66107776
91Lysine degradation_Homo sapiens_hsa003100.65151454
92Oocyte meiosis_Homo sapiens_hsa041140.64052353
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.62803618
94Endocytosis_Homo sapiens_hsa041440.60135115
95Prostate cancer_Homo sapiens_hsa052150.59128994
96Pertussis_Homo sapiens_hsa051330.58698909
97Viral myocarditis_Homo sapiens_hsa054160.58129600
98Estrogen signaling pathway_Homo sapiens_hsa049150.57483441
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.56947347
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56835182
101AMPK signaling pathway_Homo sapiens_hsa041520.54610690
102TNF signaling pathway_Homo sapiens_hsa046680.54528029
103Renal cell carcinoma_Homo sapiens_hsa052110.54125628
104Linoleic acid metabolism_Homo sapiens_hsa005910.53816386
105Carbon metabolism_Homo sapiens_hsa012000.53593356
106VEGF signaling pathway_Homo sapiens_hsa043700.51681306
107Glioma_Homo sapiens_hsa052140.51571876
108HIF-1 signaling pathway_Homo sapiens_hsa040660.51290452
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49877519
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49690186
111Amoebiasis_Homo sapiens_hsa051460.49134493
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48223809
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46019542
114Homologous recombination_Homo sapiens_hsa034400.44309361
115Sulfur metabolism_Homo sapiens_hsa009200.44009885
116Hepatitis C_Homo sapiens_hsa051600.43677947
117Acute myeloid leukemia_Homo sapiens_hsa052210.43571465
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43375817
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.43255002
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.42770698
121Selenocompound metabolism_Homo sapiens_hsa004500.42122513
122Gap junction_Homo sapiens_hsa045400.41713139
123PPAR signaling pathway_Homo sapiens_hsa033200.41595900
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40691119
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40643003
126Biosynthesis of amino acids_Homo sapiens_hsa012300.40164232
127Glutathione metabolism_Homo sapiens_hsa004800.39617949
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39439907
129Ras signaling pathway_Homo sapiens_hsa040140.38925930
130Choline metabolism in cancer_Homo sapiens_hsa052310.38099789
131Dorso-ventral axis formation_Homo sapiens_hsa043200.35232819
132Ovarian steroidogenesis_Homo sapiens_hsa049130.35166368
133Ribosome_Homo sapiens_hsa030100.35148017
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34442303
135Apoptosis_Homo sapiens_hsa042100.34364484
136ErbB signaling pathway_Homo sapiens_hsa040120.32566637

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