CD2AP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.68224736
2nuclear pore complex assembly (GO:0051292)4.03332453
3intestinal epithelial cell development (GO:0060576)4.00930781
4hepatocyte apoptotic process (GO:0097284)3.91104052
5DNA unwinding involved in DNA replication (GO:0006268)3.87721632
6cell adhesion mediated by integrin (GO:0033627)3.67230663
7nuclear pore organization (GO:0006999)3.60380343
8interferon-gamma secretion (GO:0072643)3.57655161
9mesodermal cell differentiation (GO:0048333)3.55512808
10COPII vesicle coating (GO:0048208)3.54594629
11bundle of His cell to Purkinje myocyte communication (GO:0086069)3.53845626
12regulation of bile acid biosynthetic process (GO:0070857)3.51851927
13ribosome assembly (GO:0042255)3.48830673
14hippo signaling (GO:0035329)3.47343332
15regulation of hippo signaling (GO:0035330)3.44918364
16regulation of nucleobase-containing compound transport (GO:0032239)3.44881024
17desmosome organization (GO:0002934)3.44576437
18cellular glucuronidation (GO:0052695)3.32219438
19renal filtration (GO:0097205)3.25993056
20mitotic chromosome condensation (GO:0007076)3.24826321
21very-low-density lipoprotein particle assembly (GO:0034379)3.22402748
22embryonic foregut morphogenesis (GO:0048617)3.21897581
23nucleotide-sugar biosynthetic process (GO:0009226)3.19363813
24protein localization to chromosome, centromeric region (GO:0071459)3.11743831
25positive regulation of SMAD protein import into nucleus (GO:0060391)3.09258486
26glucuronate metabolic process (GO:0019585)3.06356583
27uronic acid metabolic process (GO:0006063)3.06356583
28regulation of SMAD protein import into nucleus (GO:0060390)3.03637627
29sister chromatid segregation (GO:0000819)3.02644574
30mitotic sister chromatid cohesion (GO:0007064)2.98910485
31pore complex assembly (GO:0046931)2.97323098
32dorsal/ventral axis specification (GO:0009950)2.90958430
33formation of translation preinitiation complex (GO:0001731)2.90503797
34paraxial mesoderm development (GO:0048339)2.90076028
35angiotensin maturation (GO:0002003)2.89152536
36hypotonic response (GO:0006971)2.88743450
37cellular protein complex localization (GO:0034629)2.88518795
38protein localization to kinetochore (GO:0034501)2.88425237
39glomerular visceral epithelial cell development (GO:0072015)2.86987747
40cytoplasmic mRNA processing body assembly (GO:0033962)2.85738742
41epithelial cell-cell adhesion (GO:0090136)2.84631535
42mitotic nuclear envelope disassembly (GO:0007077)2.81242385
43glomerular basement membrane development (GO:0032836)2.81197770
44gap junction assembly (GO:0016264)2.80745706
45tight junction assembly (GO:0070830)2.80519786
46regulation of histone H3-K9 methylation (GO:0051570)2.79961170
47pre-miRNA processing (GO:0031054)2.79586275
48mitotic sister chromatid segregation (GO:0000070)2.79251159
49regulation of centriole replication (GO:0046599)2.79165414
50positive regulation of chromosome segregation (GO:0051984)2.78059709
51regulation of translational fidelity (GO:0006450)2.77826972
52DNA duplex unwinding (GO:0032508)2.76151158
53protein complex localization (GO:0031503)2.75452918
54negative regulation of DNA repair (GO:0045738)2.74874236
55DNA topological change (GO:0006265)2.73540723
56positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.72279547
57mitotic metaphase plate congression (GO:0007080)2.71454211
58skin morphogenesis (GO:0043589)2.70826763
59lung vasculature development (GO:0060426)2.70671071
60UDP-N-acetylglucosamine metabolic process (GO:0006047)2.70401791
61negative regulation of keratinocyte proliferation (GO:0010839)2.69741224
62lung lobe morphogenesis (GO:0060463)2.68919027
63establishment of integrated proviral latency (GO:0075713)2.68729480
64positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.68293057
65positive regulation of mitotic sister chromatid separation (GO:1901970)2.68293057
66positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.68293057
67iron ion import (GO:0097286)2.68257390
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68159294
69organ formation (GO:0048645)2.67984169
70anterior/posterior axis specification, embryo (GO:0008595)2.67713285
71proline biosynthetic process (GO:0006561)2.67661292
72regulation of cholesterol homeostasis (GO:2000188)2.66686305
73regulation of cell fate specification (GO:0042659)2.65036069
74regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64161150
75membrane disassembly (GO:0030397)2.63665246
76nuclear envelope disassembly (GO:0051081)2.63665246
77growth hormone receptor signaling pathway (GO:0060396)2.62685132
78DNA geometric change (GO:0032392)2.62265099
79positive regulation of glycoprotein biosynthetic process (GO:0010560)2.61735654
80positive regulation of p38MAPK cascade (GO:1900745)2.61534766
81negative regulation of cell fate specification (GO:0009996)2.61207732
82regulation of cardioblast differentiation (GO:0051890)2.61152585
83positive regulation of protein localization to plasma membrane (GO:1903078)2.60897893
84regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.59994929
85glomerular epithelial cell development (GO:0072310)2.59694764
86mRNA stabilization (GO:0048255)2.58175755
87RNA stabilization (GO:0043489)2.58175755
88regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.57776233
89regulation of transforming growth factor beta2 production (GO:0032909)2.57182958
90cell-substrate junction assembly (GO:0007044)2.56398122
91plasma lipoprotein particle assembly (GO:0034377)2.56096845
92O-glycan processing (GO:0016266)2.55638082
93epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55288285
94trophectodermal cell differentiation (GO:0001829)2.54728425
95regulation of sister chromatid cohesion (GO:0007063)2.54489023
96regulation of chromatin silencing (GO:0031935)2.54387691
97protein localization to endosome (GO:0036010)2.54055611
98cell migration involved in sprouting angiogenesis (GO:0002042)2.53440616
99urea cycle (GO:0000050)2.52792301
100ectoderm development (GO:0007398)2.51994305
101endothelial cell morphogenesis (GO:0001886)2.51580307
102regulation of keratinocyte differentiation (GO:0045616)2.48327768
103protein export from nucleus (GO:0006611)2.48292624
104regulation of RNA export from nucleus (GO:0046831)2.47947963
105heterochromatin organization (GO:0070828)2.47607379
106basement membrane organization (GO:0071711)2.47148226
107embryonic process involved in female pregnancy (GO:0060136)2.41314644
108homocysteine metabolic process (GO:0050667)2.41191276
109urea metabolic process (GO:0019627)2.40656722
110protein-lipid complex assembly (GO:0065005)2.40014927
111regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.39931187
112NLS-bearing protein import into nucleus (GO:0006607)2.38233595
113nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.37644419
114positive regulation of glycoprotein metabolic process (GO:1903020)2.37406199
115cell differentiation involved in embryonic placenta development (GO:0060706)2.37181015
116positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.37113789
117metaphase plate congression (GO:0051310)2.37054208
118regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.36386410
119negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.36198515
120folic acid-containing compound biosynthetic process (GO:0009396)2.36177755
121establishment of epithelial cell polarity (GO:0090162)2.35592869
122sphingomyelin metabolic process (GO:0006684)2.34968886
123regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.34361732
124branching involved in salivary gland morphogenesis (GO:0060445)2.33809222
125regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.33618884
126lung-associated mesenchyme development (GO:0060484)2.32971684
127DNA conformation change (GO:0071103)2.32514567
128regulation of tight junction assembly (GO:2000810)2.31906413
129respiratory tube development (GO:0030323)2.31494093
130transcytosis (GO:0045056)2.31284611
131branching involved in prostate gland morphogenesis (GO:0060442)2.31140803
132cellular response to growth hormone stimulus (GO:0071378)2.30797277
133intestinal absorption (GO:0050892)2.30414952
134lipoprotein transport (GO:0042953)2.30387591
135vascular endothelial growth factor signaling pathway (GO:0038084)2.30054284
136double-strand break repair via nonhomologous end joining (GO:0006303)2.29888135
137non-recombinational repair (GO:0000726)2.29888135
138oocyte development (GO:0048599)2.29885586
139gastrulation with mouth forming second (GO:0001702)2.29417056
140regulation of centrosome duplication (GO:0010824)2.29321658
141positive regulation of catenin import into nucleus (GO:0035413)2.29157102
142chondrocyte proliferation (GO:0035988)2.29118558
143lymph vessel development (GO:0001945)2.29078519
144platelet-derived growth factor receptor signaling pathway (GO:0048008)2.29068415
145regulation of centrosome cycle (GO:0046605)2.29032050
146renal system development (GO:0072001)2.28690011
147establishment of apical/basal cell polarity (GO:0035089)2.28441164
148mRNA modification (GO:0016556)2.28075246
149dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.27514786
150notochord development (GO:0030903)2.26537687
151cellular response to epidermal growth factor stimulus (GO:0071364)2.26113865
152apoptotic cell clearance (GO:0043277)2.25853635
153regulation of DNA endoreduplication (GO:0032875)2.25717116
154NADH metabolic process (GO:0006734)2.25329271
155hematopoietic stem cell differentiation (GO:0060218)2.25146990
156mitotic G2/M transition checkpoint (GO:0044818)2.25126305
157cellular response to vitamin D (GO:0071305)2.24913832
158response to epidermal growth factor (GO:0070849)2.24727922
159COPI coating of Golgi vesicle (GO:0048205)2.24621104
160Golgi transport vesicle coating (GO:0048200)2.24621104
161cell-cell junction assembly (GO:0007043)2.23592828
162regulation of gene silencing by RNA (GO:0060966)2.23239118
163regulation of posttranscriptional gene silencing (GO:0060147)2.23239118
164regulation of gene silencing by miRNA (GO:0060964)2.23239118
165regulation of water loss via skin (GO:0033561)2.22914820
166cellular response to vitamin (GO:0071295)2.22701700
167chromosome condensation (GO:0030261)2.21930444
168cytoskeletal anchoring at plasma membrane (GO:0007016)2.21419687
169mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.21225272
170regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.20951149
171regulation of chromosome segregation (GO:0051983)2.19936544
172mammary gland development (GO:0030879)2.17930709
173blood vessel endothelial cell migration (GO:0043534)2.16542980
174cellular response to interferon-alpha (GO:0035457)2.15293311
175regulation of chemokine secretion (GO:0090196)2.15273777
176establishment of endothelial barrier (GO:0061028)2.14346388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.73474836
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.81546649
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40263154
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.17170582
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.99027916
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.80702907
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.79943762
8CLOCK_20551151_ChIP-Seq_293T_Human2.75286083
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.73019106
10AR_21909140_ChIP-Seq_LNCAP_Human2.72080967
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66516338
12E2F7_22180533_ChIP-Seq_HELA_Human2.54140871
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.50246469
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40623371
15* FOXO3_23340844_ChIP-Seq_DLD1_Human2.26108718
16* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.24525197
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.18170740
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.18170740
19GATA1_22025678_ChIP-Seq_K562_Human2.13583673
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.12740223
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12621957
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10562004
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.10315290
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.08790942
25SALL4_18804426_ChIP-ChIP_XEN_Mouse2.08465662
26ESR2_21235772_ChIP-Seq_MCF-7_Human2.05426047
27PPAR_26484153_Chip-Seq_NCI-H1993_Human2.04511595
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.01803638
29GATA6_25053715_ChIP-Seq_YYC3_Human2.00952369
30GATA4_25053715_ChIP-Seq_YYC3_Human1.96301783
31FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.87681502
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.84900543
33CDX2_20551321_ChIP-Seq_CACO-2_Human1.78938366
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77842087
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75859631
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68517763
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.67194078
38SOX2_20726797_ChIP-Seq_SW620_Human1.66848445
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65947358
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.64544746
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.62163094
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61949579
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60095950
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58607090
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.56685251
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55951963
47* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54656802
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51432597
49CJUN_26792858_Chip-Seq_BT549_Human1.50265613
50EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.49818754
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48556279
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47231705
53ZNF263_19887448_ChIP-Seq_K562_Human1.46957350
54ATF3_27146783_Chip-Seq_COLON_Human1.46281987
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45042267
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45042267
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45042267
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43799807
59BRD4_25478319_ChIP-Seq_HGPS_Human1.43427746
60RXR_22158963_ChIP-Seq_LIVER_Mouse1.42352225
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41705719
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.41158592
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40839850
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38994385
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35022160
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33638336
67* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33156211
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32228232
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31697947
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30824338
71* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30141674
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29093497
73* GATA3_24758297_ChIP-Seq_MCF-7_Human1.28252938
74CHD1_26751641_Chip-Seq_LNCaP_Human1.27530346
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26600966
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25599009
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.24854015
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21607624
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.21167800
80FOXA2_19822575_ChIP-Seq_HepG2_Human1.18893159
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18522230
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17159564
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.17117072
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16962781
85* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16286309
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16138734
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16103362
88ELK1_19687146_ChIP-ChIP_HELA_Human1.15759121
89FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.14551543
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13684039
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11296197
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10737185
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08421294
94* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08185891
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08029296
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07347913
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07343169
98KLF5_25053715_ChIP-Seq_YYC3_Human1.06754468
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06582446
100* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06489709
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06465524
102* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05931118
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.05089633
104TP53_16413492_ChIP-PET_HCT116_Human1.04438391
105SOX17_20123909_ChIP-Seq_XEN_Mouse1.03177764
106EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02435528
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01955892
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01545907
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01363875
110* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00976449
111ELF5_23300383_ChIP-Seq_T47D_Human1.00183960
112* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98204788
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97526165
114RACK7_27058665_Chip-Seq_MCF-7_Human0.97321975
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96869683
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96395978
117* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96077235
118FOXA1_25552417_ChIP-Seq_VCAP_Human0.95820223
119AHR_22903824_ChIP-Seq_MCF-7_Human0.93275296
120JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92318852
121* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91606545
122* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90674822
123EP300_21415370_ChIP-Seq_HL-1_Mouse0.89986747
124MYC_22102868_ChIP-Seq_BL_Human0.89694053
125TP63_23658742_ChIP-Seq_EP156T_Human0.89498106
126TFEB_21752829_ChIP-Seq_HELA_Human0.89441057
127HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89095414
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88830059
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88504887
130NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87814294
131DCP1A_22483619_ChIP-Seq_HELA_Human0.87737193
132FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85675326
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85455957
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84822459
135YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84206683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.57625033
2MP0000537_abnormal_urethra_morphology3.49448301
3MP0008057_abnormal_DNA_replication3.29220899
4MP0003705_abnormal_hypodermis_morpholog2.96848149
5MP0010352_gastrointestinal_tract_polyps2.81293129
6MP0004264_abnormal_extraembryonic_tissu2.56369667
7MP0010678_abnormal_skin_adnexa2.30342591
8MP0003300_gastrointestinal_ulcer2.28967057
9MP0006054_spinal_hemorrhage2.23743495
10MP0004272_abnormal_basement_membrane2.03760189
11MP0003566_abnormal_cell_adhesion2.03138400
12MP0009697_abnormal_copulation1.99563907
13MP0005275_abnormal_skin_tensile1.95910248
14MP0003252_abnormal_bile_duct1.91541283
15MP0010094_abnormal_chromosome_stability1.91275897
16MP0002396_abnormal_hematopoietic_system1.90004514
17MP0003111_abnormal_nucleus_morphology1.89126560
18MP0003453_abnormal_keratinocyte_physiol1.74143427
19MP0000383_abnormal_hair_follicle1.70917106
20MP0005076_abnormal_cell_differentiation1.69335554
21MP0003941_abnormal_skin_development1.64427450
22MP0003868_abnormal_feces_composition1.62995090
23MP0003077_abnormal_cell_cycle1.61331091
24MP0008438_abnormal_cutaneous_collagen1.60909793
25MP0002138_abnormal_hepatobiliary_system1.60795591
26MP0004147_increased_porphyrin_level1.59646789
27MP0002796_impaired_skin_barrier1.58966083
28MP0002060_abnormal_skin_morphology1.54942604
29MP0009384_cardiac_valve_regurgitation1.54762908
30MP0009053_abnormal_anal_canal1.53855417
31MP0002006_tumorigenesis1.51951487
32MP0002254_reproductive_system_inflammat1.49733380
33MP0002098_abnormal_vibrissa_morphology1.47564695
34MP0005023_abnormal_wound_healing1.44571320
35MP0010368_abnormal_lymphatic_system1.39818458
36MP0005367_renal/urinary_system_phenotyp1.36016647
37MP0000516_abnormal_urinary_system1.36016647
38MP0003183_abnormal_peptide_metabolism1.35613030
39MP0004782_abnormal_surfactant_physiolog1.30895034
40MP0004185_abnormal_adipocyte_glucose1.30824746
41MP0005409_darkened_coat_color1.30563534
42MP0003718_maternal_effect1.29591940
43MP0000490_abnormal_crypts_of1.29238824
44MP0001666_abnormal_nutrient_absorption1.28491696
45MP0008932_abnormal_embryonic_tissue1.28384991
46MP0002877_abnormal_melanocyte_morpholog1.28017336
47MP0001849_ear_inflammation1.27424562
48MP0010307_abnormal_tumor_latency1.27276988
49MP0001216_abnormal_epidermal_layer1.25911804
50MP0005501_abnormal_skin_physiology1.25527117
51MP0000462_abnormal_digestive_system1.24434357
52MP0001879_abnormal_lymphatic_vessel1.23164909
53MP0005451_abnormal_body_composition1.23070952
54MP0005085_abnormal_gallbladder_physiolo1.21973471
55MP0000377_abnormal_hair_follicle1.20912598
56MP0002009_preneoplasia1.20250079
57MP0003115_abnormal_respiratory_system1.17289899
58MP0005360_urolithiasis1.15797264
59MP0002086_abnormal_extraembryonic_tissu1.15558191
60MP0003656_abnormal_erythrocyte_physiolo1.15442921
61MP0003890_abnormal_embryonic-extraembry1.13798781
62MP0003283_abnormal_digestive_organ1.12047373
63MP0003937_abnormal_limbs/digits/tail_de1.09733991
64MP0003091_abnormal_cell_migration1.09027238
65MP0002080_prenatal_lethality1.08824707
66MP0008007_abnormal_cellular_replicative1.08418436
67MP0000627_abnormal_mammary_gland1.07641828
68MP0002896_abnormal_bone_mineralization1.07272295
69MP0005623_abnormal_meninges_morphology1.06442217
70MP0005248_abnormal_Harderian_gland1.06205531
71MP0003950_abnormal_plasma_membrane1.04595589
72MP0002139_abnormal_hepatobiliary_system1.03933286
73MP0004197_abnormal_fetal_growth/weight/1.03767781
74MP0003045_fibrosis1.03496779
75MP0004957_abnormal_blastocyst_morpholog1.03480590
76MP0005365_abnormal_bile_salt1.02556003
77MP0009672_abnormal_birth_weight1.02346933
78MP0002928_abnormal_bile_duct1.01475135
79MP0008058_abnormal_DNA_repair1.00921330
80MP0003693_abnormal_embryo_hatching1.00214134
81MP0002088_abnormal_embryonic_growth/wei0.99139667
82MP0002084_abnormal_developmental_patter0.99112275
83MP0003984_embryonic_growth_retardation0.98570293
84MP0002092_abnormal_eye_morphology0.98187113
85MP0000477_abnormal_intestine_morphology0.97909781
86MP0001672_abnormal_embryogenesis/_devel0.97543454
87MP0005380_embryogenesis_phenotype0.97543454
88MP0008004_abnormal_stomach_pH0.97098846
89MP0010155_abnormal_intestine_physiology0.96449681
90MP0001915_intracranial_hemorrhage0.94532287
91MP0004808_abnormal_hematopoietic_stem0.94164957
92MP0003119_abnormal_digestive_system0.93285865
93MP0000427_abnormal_hair_cycle0.93218160
94MP0001958_emphysema0.92840264
95MP0004947_skin_inflammation0.91554456
96MP0001730_embryonic_growth_arrest0.91515435
97MP0005167_abnormal_blood-brain_barrier0.91502585
98MP0004019_abnormal_vitamin_homeostasis0.91392884
99MP0000733_abnormal_muscle_development0.91176996
100MP0005220_abnormal_exocrine_pancreas0.90463712
101MP0005408_hypopigmentation0.90184250
102MP0002697_abnormal_eye_size0.89572837
103MP0000432_abnormal_head_morphology0.88158648
104MP0003943_abnormal_hepatobiliary_system0.88135900
105MP0005666_abnormal_adipose_tissue0.87126720
106MP0001661_extended_life_span0.86801903
107MP0001881_abnormal_mammary_gland0.86156957
108MP0003315_abnormal_perineum_morphology0.85298896
109MP0005187_abnormal_penis_morphology0.85184362
110MP0002166_altered_tumor_susceptibility0.85069647
111MP0000647_abnormal_sebaceous_gland0.83133369
112MP0000609_abnormal_liver_physiology0.83057120
113MP0002085_abnormal_embryonic_tissue0.82854832
114MP0003567_abnormal_fetal_cardiomyocyte0.82739810
115MP0009840_abnormal_foam_cell0.82584033
116MP0001286_abnormal_eye_development0.82511973
117MP0003936_abnormal_reproductive_system0.82417663
118MP0000678_abnormal_parathyroid_gland0.82347598
119MP0003806_abnormal_nucleotide_metabolis0.81933532
120MP0002925_abnormal_cardiovascular_devel0.81110251
121MP0003935_abnormal_craniofacial_develop0.80855082
122MP0005621_abnormal_cell_physiology0.80134857
123* MP0002136_abnormal_kidney_physiology0.79944828
124MP0001697_abnormal_embryo_size0.79498698
125* MP0009643_abnormal_urine_homeostasis0.79008739
126MP0000762_abnormal_tongue_morphology0.78563044
127MP0000579_abnormal_nail_morphology0.77689552
128MP0000313_abnormal_cell_death0.76962960
129MP0000767_abnormal_smooth_muscle0.76856685
130MP0003191_abnormal_cellular_cholesterol0.76623799
131MP0000467_abnormal_esophagus_morphology0.76443772
132MP0001191_abnormal_skin_condition0.76301588
133MP0010771_integument_phenotype0.75930960
134MP0001873_stomach_inflammation0.75269439
135MP0000350_abnormal_cell_proliferation0.74347128
136MP0009703_decreased_birth_body0.72846163
137MP0005636_abnormal_mineral_homeostasis0.68710554
138MP0009931_abnormal_skin_appearance0.65327409
139MP0009379_abnormal_foot_pigmentation0.65314925
140MP0001188_hyperpigmentation0.64711915

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)3.85310806
2Acanthocytosis (HP:0001927)3.70281244
3Hypobetalipoproteinemia (HP:0003563)3.32433573
4Subacute progressive viral hepatitis (HP:0006572)3.27726103
5Micronodular cirrhosis (HP:0001413)3.17258543
6Biliary tract neoplasm (HP:0100574)3.16052793
7Rectal prolapse (HP:0002035)3.12572903
8Esophageal varix (HP:0002040)3.11061610
9Hyperactive renin-angiotensin system (HP:0000841)3.06846563
10Atrophic scars (HP:0001075)2.96453091
11Aortic aneurysm (HP:0004942)2.91809419
12Milia (HP:0001056)2.91429019
13Curly hair (HP:0002212)2.91109325
14* Focal segmental glomerulosclerosis (HP:0000097)2.86412080
15Fat malabsorption (HP:0002630)2.84258531
16Papillary thyroid carcinoma (HP:0002895)2.77551720
17Acute myeloid leukemia (HP:0004808)2.65166986
18Chromsome breakage (HP:0040012)2.59967168
19Hematochezia (HP:0002573)2.58768252
20Abnormal biliary tract morphology (HP:0012440)2.56422061
21Osteolytic defects of the phalanges of the hand (HP:0009771)2.55806991
22Osteolytic defects of the hand bones (HP:0009699)2.55806991
23Malignant gastrointestinal tract tumors (HP:0006749)2.54035246
24Gastrointestinal carcinoma (HP:0002672)2.54035246
25* Glomerulosclerosis (HP:0000096)2.46493685
26Onycholysis (HP:0001806)2.44091407
27Conjugated hyperbilirubinemia (HP:0002908)2.40842741
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.35953588
29Abnormality of oral frenula (HP:0000190)2.35707807
30Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.35188527
31Malnutrition (HP:0004395)2.34374842
32Cerebral aneurysm (HP:0004944)2.32732449
33Nephroblastoma (Wilms tumor) (HP:0002667)2.27502061
34Abnormality of small intestinal villus morphology (HP:0011472)2.24317847
35Villous atrophy (HP:0011473)2.24317847
36Uterine neoplasm (HP:0010784)2.23330368
37Abnormality of the nasal septum (HP:0000419)2.20454181
38Chronic diarrhea (HP:0002028)2.17196782
39Multiple enchondromatosis (HP:0005701)2.16903972
40Shallow orbits (HP:0000586)2.15508078
41Flat acetabular roof (HP:0003180)2.14144707
42Embryonal renal neoplasm (HP:0011794)2.13797441
43Neoplasm of the small intestine (HP:0100833)2.12354327
44Aortic dissection (HP:0002647)2.11930320
45Abnormality of the gastric mucosa (HP:0004295)2.11083813
46Poikilocytosis (HP:0004447)2.09004299
47Abnormal tarsal ossification (HP:0008369)2.08470029
48Ankle contracture (HP:0006466)2.08435709
49Hypolipoproteinemia (HP:0010981)2.07370065
50Abnormal cartilage morphology (HP:0002763)2.06802474
51Deviation of the thumb (HP:0009603)2.05499533
52Deep philtrum (HP:0002002)2.05290636
53Tetraparesis (HP:0002273)2.04315608
54Abdominal distention (HP:0003270)2.04182185
55Rhabdomyosarcoma (HP:0002859)2.04003657
56Ileus (HP:0002595)2.02065968
57Abnormal pancreas size (HP:0012094)1.99102782
58Premature rupture of membranes (HP:0001788)1.99002890
59Myocardial infarction (HP:0001658)1.98645836
60Alopecia of scalp (HP:0002293)1.98521538
61Plantar hyperkeratosis (HP:0007556)1.98001097
62Anal stenosis (HP:0002025)1.97971302
63Woolly hair (HP:0002224)1.97749469
64Symptomatic seizures (HP:0011145)1.97693678
65Cardiovascular calcification (HP:0011915)1.96565973
66Gout (HP:0001997)1.93575594
67Aneurysm (HP:0002617)1.93097619
68Abnormality of the distal phalanges of the toes (HP:0010182)1.92543136
69Abnormality of the distal phalanx of the thumb (HP:0009617)1.91697760
70Neoplasm of the rectum (HP:0100743)1.91328251
71Abnormal foot bone ossification (HP:0010675)1.91016405
72Arterial tortuosity (HP:0005116)1.90826706
73Ulnar bowing (HP:0003031)1.90739681
74Missing ribs (HP:0000921)1.89194772
75Thyroid carcinoma (HP:0002890)1.88805515
76Abnormal hemoglobin (HP:0011902)1.88749840
77Steatorrhea (HP:0002570)1.88653196
78Vascular calcification (HP:0004934)1.88626785
79Mitral valve prolapse (HP:0001634)1.88047617
80Asymmetry of the thorax (HP:0001555)1.87664807
81Abnormality of the salivary glands (HP:0010286)1.87347392
82Abnormality of the common coagulation pathway (HP:0010990)1.85742151
83Hypoplastic labia majora (HP:0000059)1.85500914
84Insidious onset (HP:0003587)1.85188165
85Termporal pattern (HP:0011008)1.85188165
86Proximal placement of thumb (HP:0009623)1.84865364
87Fragile skin (HP:0001030)1.83598170
88Lip pit (HP:0100267)1.83231451
89Septate vagina (HP:0001153)1.82755806
90Hypoglycemic seizures (HP:0002173)1.82705738
91Blepharitis (HP:0000498)1.82601058
92Potter facies (HP:0002009)1.81985029
93Facial shape deformation (HP:0011334)1.81985029
94Proximal tubulopathy (HP:0000114)1.81800395
95Nail dystrophy (HP:0008404)1.81609861
96Vascular tortuosity (HP:0004948)1.80586156
97Short humerus (HP:0005792)1.80348503
98Urethral obstruction (HP:0000796)1.79044836
99Pustule (HP:0200039)1.78647841
100Transitional cell carcinoma of the bladder (HP:0006740)1.78509012
101Abnormality of the 1st metacarpal (HP:0010009)1.77925683
102Abnormal vertebral ossification (HP:0100569)1.77641550
103Progressive hearing impairment (HP:0001730)1.75417018
104Abnormal hair laboratory examination (HP:0003328)1.75284045
105Abnormality of nail color (HP:0100643)1.75221705
106Pili torti (HP:0003777)1.74880801
107Tubular atrophy (HP:0000092)1.74455284
108Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73611901
109Megaloblastic anemia (HP:0001889)1.73212118
110Fragile nails (HP:0001808)1.73044578
111Advanced eruption of teeth (HP:0006288)1.72852414
112Increased nuchal translucency (HP:0010880)1.72804443
113Abnormality of proline metabolism (HP:0010907)1.72625436
114Hydroxyprolinuria (HP:0003080)1.72625436
115Sandal gap (HP:0001852)1.71617378
116Abnormality of vitamin metabolism (HP:0100508)1.71338523
117Short hallux (HP:0010109)1.69867069
118Selective tooth agenesis (HP:0001592)1.69865091
119Abnormality of chromosome stability (HP:0003220)1.69731761
120Shawl scrotum (HP:0000049)1.69415585
121Protrusio acetabuli (HP:0003179)1.68972623
122Bladder neoplasm (HP:0009725)1.68484383
123Bladder carcinoma (HP:0002862)1.68484383
124Nephritis (HP:0000123)1.68328369
125Ankyloglossia (HP:0010296)1.67686405
126Ovarian neoplasm (HP:0100615)1.66990664
127Cervical subluxation (HP:0003308)1.66319291
128Hyponatremia (HP:0002902)1.66048453
129Subcapsular cataract (HP:0000523)1.65555371
130Breast carcinoma (HP:0003002)1.64840627
131Uterine leiomyosarcoma (HP:0002891)1.64669364
132Leiomyosarcoma (HP:0100243)1.64669364
133Abnormality of the fingertips (HP:0001211)1.64440397
134Enlarged penis (HP:0000040)1.64362083
135Germ cell neoplasia (HP:0100728)1.63972974
136Increased purine levels (HP:0004368)1.63935453
137Hyperuricemia (HP:0002149)1.63935453
138Abnormality of the vitamin B12 metabolism (HP:0004341)1.63655935
139Vertebral clefting (HP:0008428)1.63415857
140Short middle phalanx of finger (HP:0005819)1.63190044
141Intrahepatic cholestasis (HP:0001406)1.62159515
142Hyperglycemia (HP:0003074)1.62137301
143Abnormality of monocarboxylic acid metabolism (HP:0010996)1.62095518
144Persistence of primary teeth (HP:0006335)1.61918721
145Hepatocellular carcinoma (HP:0001402)1.61798243
146Colon cancer (HP:0003003)1.61713831
147Increased connective tissue (HP:0009025)1.61678510
148Lower limb hyperreflexia (HP:0002395)1.60663262
149Abnormality of glutamine family amino acid metabolism (HP:0010902)1.60268646
150Esophageal atresia (HP:0002032)1.60125800
151Abnormality of the labia majora (HP:0012881)1.58973209
152Interstitial pulmonary disease (HP:0006530)1.57617823
153Trismus (HP:0000211)1.57601547
154Abnormality of chloride homeostasis (HP:0011422)1.57353688
155Ureteral obstruction (HP:0006000)1.56161924
156Back pain (HP:0003418)1.55609373
157Hypoplasia of dental enamel (HP:0006297)1.55270535
158Natal tooth (HP:0000695)1.54731969
159Aplasia/hypoplasia of the humerus (HP:0006507)1.54181303

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.68926595
2FRK3.86494308
3LATS13.73035182
4MST42.75979555
5CDK122.63231475
6STK242.41037366
7PBK2.35406008
8EIF2AK12.16999934
9EIF2AK32.15775733
10MST1R2.08507751
11PTK61.98629193
12FER1.97328590
13RIPK11.97000278
14MET1.95783663
15STK101.94116261
16STK31.87733821
17TSSK61.87528118
18RPS6KB21.73665891
19PAK41.69607326
20TAF11.69273237
21NEK91.67218556
22SRPK11.66717607
23NUAK11.55658958
24TGFBR21.55196988
25NEK11.46697304
26LRRK21.46515554
27EPHB21.46215955
28MAP3K21.43772961
29PTK21.43733433
30MAP2K21.42274733
31CDK61.40177547
32TTN1.38070341
33PDGFRA1.37425371
34ACVR1B1.37051985
35SMG11.32529704
36MKNK11.30792349
37MKNK21.26573271
38PKN21.25824504
39ERN11.24555459
40SIK11.23057892
41MAP3K31.21201705
42TTK1.20342427
43FGFR21.19785976
44STK38L1.16406382
45NEK21.16082539
46CAMK1D1.15450267
47WEE11.13971261
48MELK1.13738275
49TGFBR11.09079936
50TRIB31.07773381
51MAP3K121.06648725
52PLK41.05014940
53MAP3K81.03071371
54FGFR41.01983130
55BUB11.00560837
56MTOR0.99027053
57DDR20.97762823
58RPS6KA40.96366590
59FGFR30.93900597
60AKT30.93831352
61LMTK20.93504135
62ERBB40.92138750
63BMX0.90534455
64SCYL20.90077755
65AURKB0.88942578
66FGFR10.87187893
67YES10.85702300
68PDGFRB0.84522743
69BMPR20.84330597
70BRD40.84187208
71EEF2K0.84032025
72TRPM70.83327356
73PRKCI0.82206365
74PAK20.80889772
75ICK0.79259405
76MAP3K100.79011612
77STK390.78425980
78DMPK0.75459322
79EPHB10.75403554
80WNK40.74426139
81EPHA30.71152167
82TNIK0.70732415
83FLT30.70595592
84INSRR0.69906880
85CDC70.69825957
86MAP3K140.69333077
87MAP2K10.68797063
88CHUK0.66364744
89PLK10.65939672
90GSK3A0.65276358
91BRSK20.64834075
92IRAK30.63144642
93DYRK1B0.60820149
94TRIM280.60345014
95ERBB20.60084951
96CHEK20.58922272
97CAMK1G0.55692985
98PDK20.55370419
99EIF2AK20.55333218
100ERBB30.54548508
101PRKG20.54219405
102CDK70.52059776
103WNK10.52037255
104LATS20.51960121
105OXSR10.50081420
106CDK90.49861033
107TAOK30.49064898
108MARK30.48006331
109PASK0.46416352
110CLK10.46207935
111ATM0.44831851
112PIK3CA0.44595770
113ALK0.44394195
114STK40.43990854
115MAP3K90.42669356
116CHEK10.42052137
117BRSK10.41157545
118EGFR0.40755312
119CSNK1A1L0.40743517
120PNCK0.40259417
121ATR0.39902743
122BCR0.39872051
123ZAK0.39071682
124SGK30.38625313
125JAK10.38534625
126AKT20.37663831
127INSR0.37241248
128PLK30.36999691
129NLK0.36189374
130CDK40.35884120
131KSR10.35077846
132PRKAA20.33503536
133CSNK1E0.33228534
134CSK0.32745329
135IGF1R0.32435272

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045202.97101083
2ECM-receptor interaction_Homo sapiens_hsa045122.36586106
3Small cell lung cancer_Homo sapiens_hsa052222.32847533
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00220367
5Non-homologous end-joining_Homo sapiens_hsa034501.94407745
6Tight junction_Homo sapiens_hsa045301.79379265
7Hippo signaling pathway_Homo sapiens_hsa043901.79297459
8Sulfur metabolism_Homo sapiens_hsa009201.76195778
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.74880907
10Focal adhesion_Homo sapiens_hsa045101.73511326
11Proteoglycans in cancer_Homo sapiens_hsa052051.68989277
12TGF-beta signaling pathway_Homo sapiens_hsa043501.64871532
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60969496
14MicroRNAs in cancer_Homo sapiens_hsa052061.60369126
15Bladder cancer_Homo sapiens_hsa052191.55961143
16Mineral absorption_Homo sapiens_hsa049781.55806430
17Thyroid cancer_Homo sapiens_hsa052161.54950253
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53736781
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.53014742
20Galactose metabolism_Homo sapiens_hsa000521.51836666
21Protein digestion and absorption_Homo sapiens_hsa049741.49178746
22DNA replication_Homo sapiens_hsa030301.47700437
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.47440501
24Lysine degradation_Homo sapiens_hsa003101.47240114
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.46294126
26Mismatch repair_Homo sapiens_hsa034301.45943061
27Prostate cancer_Homo sapiens_hsa052151.44786919
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42626864
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40816903
30Caffeine metabolism_Homo sapiens_hsa002321.40018915
31Nitrogen metabolism_Homo sapiens_hsa009101.39391621
32Fat digestion and absorption_Homo sapiens_hsa049751.39102045
33Vitamin digestion and absorption_Homo sapiens_hsa049771.35254589
34Chronic myeloid leukemia_Homo sapiens_hsa052201.25112291
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24542207
36Pancreatic cancer_Homo sapiens_hsa052121.24496949
37Fructose and mannose metabolism_Homo sapiens_hsa000511.21634938
38Basal cell carcinoma_Homo sapiens_hsa052171.19301850
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17717418
40Complement and coagulation cascades_Homo sapiens_hsa046101.15124588
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14064671
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13829558
43Amoebiasis_Homo sapiens_hsa051461.12937129
44mRNA surveillance pathway_Homo sapiens_hsa030151.10900009
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.09588805
46* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08380585
47Fatty acid biosynthesis_Homo sapiens_hsa000611.07763016
48Renin-angiotensin system_Homo sapiens_hsa046141.06667020
49Selenocompound metabolism_Homo sapiens_hsa004501.04892602
50p53 signaling pathway_Homo sapiens_hsa041151.04242954
51Endometrial cancer_Homo sapiens_hsa052131.03479212
52Toxoplasmosis_Homo sapiens_hsa051451.01986732
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01117690
54Sphingolipid metabolism_Homo sapiens_hsa006000.97126113
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94723840
56Pyruvate metabolism_Homo sapiens_hsa006200.94420479
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94129427
58Pathways in cancer_Homo sapiens_hsa052000.93462722
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93413407
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92234360
61Bile secretion_Homo sapiens_hsa049760.91594544
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90579779
63Biosynthesis of amino acids_Homo sapiens_hsa012300.89875216
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.88345208
65Spliceosome_Homo sapiens_hsa030400.88197883
66Glutathione metabolism_Homo sapiens_hsa004800.88082844
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87010019
68PPAR signaling pathway_Homo sapiens_hsa033200.84244032
69Dorso-ventral axis formation_Homo sapiens_hsa043200.83839994
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83353407
71Arginine and proline metabolism_Homo sapiens_hsa003300.83282430
72Melanoma_Homo sapiens_hsa052180.82668260
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82237491
74Cell cycle_Homo sapiens_hsa041100.81538720
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80411319
76Hedgehog signaling pathway_Homo sapiens_hsa043400.80087467
77One carbon pool by folate_Homo sapiens_hsa006700.80029430
78Chemical carcinogenesis_Homo sapiens_hsa052040.76751483
79Retinol metabolism_Homo sapiens_hsa008300.76733559
80Viral carcinogenesis_Homo sapiens_hsa052030.75973043
81Carbon metabolism_Homo sapiens_hsa012000.75671818
82FoxO signaling pathway_Homo sapiens_hsa040680.75029644
83Fatty acid degradation_Homo sapiens_hsa000710.75011002
84Nucleotide excision repair_Homo sapiens_hsa034200.73895439
85Insulin resistance_Homo sapiens_hsa049310.73385577
86Hepatitis C_Homo sapiens_hsa051600.72641447
87Colorectal cancer_Homo sapiens_hsa052100.71525204
88Vitamin B6 metabolism_Homo sapiens_hsa007500.71494156
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71350731
90Arginine biosynthesis_Homo sapiens_hsa002200.70788604
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70723498
92Renal cell carcinoma_Homo sapiens_hsa052110.69620101
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69327118
94mTOR signaling pathway_Homo sapiens_hsa041500.68983328
95HTLV-I infection_Homo sapiens_hsa051660.67281792
96TNF signaling pathway_Homo sapiens_hsa046680.67029238
97Pentose phosphate pathway_Homo sapiens_hsa000300.65158498
98RNA transport_Homo sapiens_hsa030130.64792568
99Propanoate metabolism_Homo sapiens_hsa006400.63087970
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61068567
101Tryptophan metabolism_Homo sapiens_hsa003800.61009323
102Herpes simplex infection_Homo sapiens_hsa051680.59985092
103Starch and sucrose metabolism_Homo sapiens_hsa005000.58733439
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.58497109
105Antigen processing and presentation_Homo sapiens_hsa046120.56698652
106Pancreatic secretion_Homo sapiens_hsa049720.56500088
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56087358
108Thyroid hormone synthesis_Homo sapiens_hsa049180.55899662
109Inositol phosphate metabolism_Homo sapiens_hsa005620.55315115
110Viral myocarditis_Homo sapiens_hsa054160.54683704
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.54129626
112Apoptosis_Homo sapiens_hsa042100.54013390
113N-Glycan biosynthesis_Homo sapiens_hsa005100.52885371
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52678195
115Wnt signaling pathway_Homo sapiens_hsa043100.51986115
116Hematopoietic cell lineage_Homo sapiens_hsa046400.51023513
117Rap1 signaling pathway_Homo sapiens_hsa040150.50453496
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49631858
119HIF-1 signaling pathway_Homo sapiens_hsa040660.47901609
120Fatty acid metabolism_Homo sapiens_hsa012120.47769737
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46488057
122Influenza A_Homo sapiens_hsa051640.45983568
123Notch signaling pathway_Homo sapiens_hsa043300.45867407
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44399153
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.44258970
126Hepatitis B_Homo sapiens_hsa051610.42839925
127Histidine metabolism_Homo sapiens_hsa003400.42281591
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41752713
129Phenylalanine metabolism_Homo sapiens_hsa003600.41420949
130Systemic lupus erythematosus_Homo sapiens_hsa053220.41087378
131Salmonella infection_Homo sapiens_hsa051320.40784880
132Prolactin signaling pathway_Homo sapiens_hsa049170.40171210
133Basal transcription factors_Homo sapiens_hsa030220.39485903
134Non-small cell lung cancer_Homo sapiens_hsa052230.38367506
135Glycerolipid metabolism_Homo sapiens_hsa005610.37744978
136Glioma_Homo sapiens_hsa052140.37721728
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37487121
138Insulin signaling pathway_Homo sapiens_hsa049100.37235173
139Base excision repair_Homo sapiens_hsa034100.36909576
140RNA degradation_Homo sapiens_hsa030180.36724363

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »