CD2BP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.53743468
2Golgi transport vesicle coating (GO:0048200)5.02576053
3COPI coating of Golgi vesicle (GO:0048205)5.02576053
4protein localization to kinetochore (GO:0034501)4.82565267
5protein localization to endosome (GO:0036010)4.63347172
6negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.39364715
7regulation of mammary gland epithelial cell proliferation (GO:0033599)4.10738794
8negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.01721617
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.01066045
10mitotic chromosome condensation (GO:0007076)3.93048758
11protein localization to chromosome, centromeric region (GO:0071459)3.91696975
12DNA replication-dependent nucleosome assembly (GO:0006335)3.89119138
13DNA replication-dependent nucleosome organization (GO:0034723)3.89119138
14DNA replication initiation (GO:0006270)3.87146994
15DNA strand elongation involved in DNA replication (GO:0006271)3.84207214
16pre-miRNA processing (GO:0031054)3.82460014
17sister chromatid segregation (GO:0000819)3.73510794
18negative regulation of RNA splicing (GO:0033119)3.73289600
19heterochromatin organization (GO:0070828)3.70668670
20mitotic sister chromatid segregation (GO:0000070)3.69489339
21negative regulation of erythrocyte differentiation (GO:0045647)3.65394151
22ribosomal small subunit biogenesis (GO:0042274)3.65338853
23negative regulation of mRNA processing (GO:0050686)3.63610748
24nuclear pore organization (GO:0006999)3.63154408
25negative regulation of histone methylation (GO:0031061)3.62791781
26DNA strand elongation (GO:0022616)3.59546763
27mitotic nuclear envelope disassembly (GO:0007077)3.55892908
28NIK/NF-kappaB signaling (GO:0038061)3.54638892
29folic acid-containing compound biosynthetic process (GO:0009396)3.53602616
30protein retention in ER lumen (GO:0006621)3.53152286
31peptidyl-arginine omega-N-methylation (GO:0035247)3.53005157
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52890160
33viral mRNA export from host cell nucleus (GO:0046784)3.52537781
34positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.49269450
35DNA duplex unwinding (GO:0032508)3.45276045
36histone H4-K12 acetylation (GO:0043983)3.43458683
37ncRNA 3-end processing (GO:0043628)3.42855309
38nuclear envelope disassembly (GO:0051081)3.42180972
39membrane disassembly (GO:0030397)3.42180972
40formation of translation preinitiation complex (GO:0001731)3.41004650
41mitotic metaphase plate congression (GO:0007080)3.40138953
42DNA geometric change (GO:0032392)3.39620137
43negative regulation of cell killing (GO:0031342)3.39488171
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.39488171
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38654520
46apoptotic process involved in morphogenesis (GO:0060561)3.31689611
47alternative mRNA splicing, via spliceosome (GO:0000380)3.30927722
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.30002457
49* spliceosomal tri-snRNP complex assembly (GO:0000244)3.28115161
50protein maturation by protein folding (GO:0022417)3.26485496
51* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.26317812
52* mRNA splicing, via spliceosome (GO:0000398)3.26317812
53protein-DNA complex disassembly (GO:0032986)3.25913334
54nucleosome disassembly (GO:0006337)3.25913334
55modulation by virus of host process (GO:0019054)3.25175748
56modulation by symbiont of host cellular process (GO:0044068)3.25106064
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23765110
58proline biosynthetic process (GO:0006561)3.22870952
59regulation of translational termination (GO:0006449)3.21588331
60peptidyl-arginine N-methylation (GO:0035246)3.21265676
61peptidyl-arginine methylation (GO:0018216)3.21265676
62* RNA splicing, via transesterification reactions (GO:0000375)3.19885293
63barbed-end actin filament capping (GO:0051016)3.19219687
64negative regulation of mRNA metabolic process (GO:1903312)3.17976538
65regulation of spindle organization (GO:0090224)3.17494438
66pentose-phosphate shunt (GO:0006098)3.16265904
67GDP-mannose metabolic process (GO:0019673)3.15709367
68regulation of histone H3-K9 methylation (GO:0051570)3.14174436
69DNA replication checkpoint (GO:0000076)3.13874056
70antigen processing and presentation of endogenous antigen (GO:0019883)3.10967686
713-UTR-mediated mRNA stabilization (GO:0070935)3.10625555
72regulation of RNA export from nucleus (GO:0046831)3.10398801
73IMP biosynthetic process (GO:0006188)3.07963626
74protein localization to chromosome (GO:0034502)3.06323806
75positive regulation of chromosome segregation (GO:0051984)3.04792514
76negative regulation of cell size (GO:0045792)3.03487792
77telomere maintenance via semi-conservative replication (GO:0032201)3.03118181
78viral transcription (GO:0019083)3.02990119
79nucleobase biosynthetic process (GO:0046112)3.02939656
80nuclear pore complex assembly (GO:0051292)3.01793954
81regulation of gene silencing by RNA (GO:0060966)3.01059913
82regulation of posttranscriptional gene silencing (GO:0060147)3.01059913
83regulation of gene silencing by miRNA (GO:0060964)3.01059913
84regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3.00814481
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00697703
86regulation of DNA damage checkpoint (GO:2000001)3.00010001
87histone H4-K8 acetylation (GO:0043982)2.99675182
88histone H4-K5 acetylation (GO:0043981)2.99675182
89dosage compensation (GO:0007549)2.98356095
90spliceosomal complex assembly (GO:0000245)2.96984736
91maturation of SSU-rRNA (GO:0030490)2.96651590
92regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.96567914
93histone arginine methylation (GO:0034969)2.96379762
94regulation of defense response to virus by virus (GO:0050690)2.96119754
95* spliceosomal snRNP assembly (GO:0000387)2.95612044
96translational termination (GO:0006415)2.95439500
97termination of RNA polymerase II transcription (GO:0006369)2.93681738
98activation of MAPKKK activity (GO:0000185)2.93477955
99regulation of translational fidelity (GO:0006450)2.93310545
100epithelial cell differentiation involved in prostate gland development (GO:0060742)2.91718937
101translational initiation (GO:0006413)2.89690970
102positive regulation of Cdc42 GTPase activity (GO:0043089)2.88538908
103translational elongation (GO:0006414)2.87052611
104ribosome biogenesis (GO:0042254)2.86820265
105regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.86696877
106positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.86696877
107ribosomal large subunit biogenesis (GO:0042273)2.85917260
108nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83226511
109nuclear envelope organization (GO:0006998)2.82794678
110positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.82752563
111adherens junction assembly (GO:0034333)2.81985423
112kinetochore organization (GO:0051383)2.81318276
113chromatin silencing (GO:0006342)2.81299852
114regulation of chromosome segregation (GO:0051983)2.80806950
115regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.79591596
116negative regulation of chromosome segregation (GO:0051985)2.78618121
117mannose metabolic process (GO:0006013)2.77947331
118ATP-dependent chromatin remodeling (GO:0043044)2.76394211
119mitotic G1 DNA damage checkpoint (GO:0031571)2.75145172
120mitotic recombination (GO:0006312)2.74349218
121regulation of mitotic spindle organization (GO:0060236)2.74298064
122regulation of helicase activity (GO:0051095)2.74286761
123regulation of chromatin binding (GO:0035561)2.73661423
124negative regulation of gene expression, epigenetic (GO:0045814)2.72527625
125metaphase plate congression (GO:0051310)2.72183947
126cellular response to virus (GO:0098586)2.71990036
127regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71856120
128DNA conformation change (GO:0071103)2.71556184
129polarized epithelial cell differentiation (GO:0030859)2.71279766
130mRNA transport (GO:0051028)2.71128990
131histone H2A monoubiquitination (GO:0035518)2.71091792
132chromatin assembly or disassembly (GO:0006333)2.70828893
133intracellular estrogen receptor signaling pathway (GO:0030520)2.70575094
134RNA export from nucleus (GO:0006405)2.70210328
135spindle assembly checkpoint (GO:0071173)2.68909847
136ribonucleoprotein complex biogenesis (GO:0022613)2.68539797
137regulation of sister chromatid cohesion (GO:0007063)2.68473005
138cell-substrate adherens junction assembly (GO:0007045)2.68080118
139focal adhesion assembly (GO:0048041)2.68080118
140peptidyl-lysine dimethylation (GO:0018027)2.67844782
141maternal placenta development (GO:0001893)2.67250767
142mRNA cleavage (GO:0006379)2.67058983
143mitotic spindle assembly checkpoint (GO:0007094)2.66852146
144negative regulation of mitotic sister chromatid segregation (GO:0033048)2.66740278
145regulation of early endosome to late endosome transport (GO:2000641)2.65367286
146endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.64445403
147activation of Rac GTPase activity (GO:0032863)2.62616132
148glucose catabolic process (GO:0006007)2.59594745
149regulation of superoxide anion generation (GO:0032928)2.57637421
150negative regulation of DNA-templated transcription, elongation (GO:0032785)2.54702376
151modulation by virus of host morphology or physiology (GO:0019048)2.53365692
152NADPH regeneration (GO:0006740)2.52897495
153regulation of NFAT protein import into nucleus (GO:0051532)2.51463287
154stress fiber assembly (GO:0043149)2.49659425
155protein insertion into membrane (GO:0051205)2.49268979
156antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.48842513
157mitochondrial fusion (GO:0008053)2.45883684
158positive thymic T cell selection (GO:0045059)2.45089860
159virion assembly (GO:0019068)2.44976385
160mitotic nuclear envelope reassembly (GO:0007084)2.43643505
161nuclear envelope reassembly (GO:0031468)2.43643505
162modulation by symbiont of host immune response (GO:0052553)2.43286412
163positive regulation by symbiont of host defense response (GO:0052509)2.43286412
164modulation by symbiont of host defense response (GO:0052031)2.43286412
165modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.43286412
166modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.43286412
167positive regulation by organism of defense response of other organism involved in symbiotic interact2.43286412
168thymic T cell selection (GO:0045061)2.43025221
169activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.41655067
170negative regulation of necroptotic process (GO:0060546)2.40015560
171intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.39635095
172response to muramyl dipeptide (GO:0032495)2.38726449
173glucose 6-phosphate metabolic process (GO:0051156)2.35645713
174pinocytosis (GO:0006907)2.35491408
175positive regulation of nuclease activity (GO:0032075)2.35371490
176regulation of glucose import in response to insulin stimulus (GO:2001273)2.31094261
177protein complex localization (GO:0031503)2.31084071
178response to laminar fluid shear stress (GO:0034616)2.29577161
179positive regulation of protein dephosphorylation (GO:0035307)2.29464042
180detection of bacterium (GO:0016045)2.28624512
181nucleobase-containing small molecule interconversion (GO:0015949)2.28304445
182cellular response to interleukin-4 (GO:0071353)2.27826966
183UV protection (GO:0009650)2.27629102
184mRNA stabilization (GO:0048255)2.27435018
185RNA stabilization (GO:0043489)2.27435018
186mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.26885977

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.34369092
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.82918058
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.54591213
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.28911205
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26910959
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.19870522
7MYC_22102868_ChIP-Seq_BL_Human3.01313831
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94621853
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78494593
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.67067456
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52006878
12LXR_22292898_ChIP-Seq_THP-1_Human2.39977949
13* XRN2_22483619_ChIP-Seq_HELA_Human2.34683558
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32752788
15CIITA_25753668_ChIP-Seq_RAJI_Human2.31454810
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20184636
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19836151
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19802377
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14537691
20* ETS1_20019798_ChIP-Seq_JURKAT_Human2.10344678
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.99498270
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93603329
23VDR_21846776_ChIP-Seq_THP-1_Human1.88607829
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84877867
25RACK7_27058665_Chip-Seq_MCF-7_Human1.84576702
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83709808
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.82868259
28* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.82524129
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76528447
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74674733
31* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.73323028
32* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.72840587
33ZNF263_19887448_ChIP-Seq_K562_Human1.72549101
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71323100
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71236129
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70873193
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69759012
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69372231
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.68691215
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68269521
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63643852
42* KDM5A_27292631_Chip-Seq_BREAST_Human1.61908131
43TTF2_22483619_ChIP-Seq_HELA_Human1.61597261
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.59300815
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59219449
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57329398
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56103914
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.54542418
49* GABP_17652178_ChIP-ChIP_JURKAT_Human1.52054901
50* GABP_19822575_ChIP-Seq_HepG2_Human1.51788481
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50603547
52* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49488107
53FOXP3_21729870_ChIP-Seq_TREG_Human1.47993181
54VDR_23849224_ChIP-Seq_CD4+_Human1.47709156
55AR_21909140_ChIP-Seq_LNCAP_Human1.47376230
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46559985
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46202950
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45437456
59DCP1A_22483619_ChIP-Seq_HELA_Human1.45313702
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.42917716
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41848071
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40515186
63* SA1_27219007_Chip-Seq_ERYTHROID_Human1.39652201
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36951318
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36203715
66KDM2B_26808549_Chip-Seq_DND41_Human1.34399173
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34166925
68* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33583545
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32169420
70* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31601753
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31503341
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31503341
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31503341
74VDR_24763502_ChIP-Seq_THP-1_Human1.31320474
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30039276
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29266325
77KDM2B_26808549_Chip-Seq_K562_Human1.28455244
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26488680
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.24502685
80* ELF1_20517297_ChIP-Seq_JURKAT_Human1.24425377
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23790819
82* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23724812
83* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23597771
84* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22819445
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22738758
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.21513843
87* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20849388
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20733719
89SMC4_20622854_ChIP-Seq_HELA_Human1.20437334
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20394539
91TCF7_22412390_ChIP-Seq_EML_Mouse1.19461842
92TFEB_21752829_ChIP-Seq_HELA_Human1.19054875
93* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18953791
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.18565382
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17523292
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.17521344
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.17510989
98CLOCK_20551151_ChIP-Seq_293T_Human1.17299854
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16689613
100BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16652479
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16198729
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15897819
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15354796
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15089124
105* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14171510
106* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13779564
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11919020
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11787835
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11083975
110* UTX_26944678_Chip-Seq_JUKART_Human1.11083595
111TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10947822
112PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10874035
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10401767
114ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10125588
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09878736
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09265389
117ELK3_25401928_ChIP-Seq_HUVEC_Human1.07965751
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07712904
119TP53_22127205_ChIP-Seq_IMR90_Human1.07256383
120* BCOR_27268052_Chip-Seq_Bcells_Human1.07181656
121* ATF3_27146783_Chip-Seq_COLON_Human1.06801330
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06738387
123* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05620380
124GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04788888
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04661906
126CTCF_26484167_Chip-Seq_Bcells_Mouse1.04310941
127* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03691120
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03466641
129BCL6_27268052_Chip-Seq_Bcells_Human1.02935180
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02894132
131CREB1_26743006_Chip-Seq_LNCaP_Human1.02695036
132* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02499265
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01345342
134KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01279352
135MAF_26560356_Chip-Seq_TH1_Human0.99508440
136OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99472513
137ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97331855
138CHD1_26751641_Chip-Seq_LNCaP_Human0.96248562
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94820042
140TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94291562
141NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.94266445
142SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92538487
143EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91982699
144PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91237712
145FOXP1_21924763_ChIP-Seq_HESCs_Human0.90996734
146MAF_26560356_Chip-Seq_TH2_Human0.90777789
147NCOR1_26117541_ChIP-Seq_K562_Human0.90327290
148* ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88673903
149ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87829920
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86597234
151P68_20966046_ChIP-Seq_HELA_Human0.86106785
152NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.85293664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.26006078
2MP0003111_abnormal_nucleus_morphology3.89687331
3MP0004957_abnormal_blastocyst_morpholog3.61512948
4MP0010094_abnormal_chromosome_stability3.59598118
5MP0008260_abnormal_autophagy3.58934398
6MP0003705_abnormal_hypodermis_morpholog3.57584458
7MP0008057_abnormal_DNA_replication3.50603190
8MP0003077_abnormal_cell_cycle3.35793623
9MP0005058_abnormal_lysosome_morphology3.33476648
10MP0005451_abnormal_body_composition3.31230760
11MP0003123_paternal_imprinting3.08132851
12MP0003436_decreased_susceptibility_to2.83475140
13MP0001730_embryonic_growth_arrest2.82164919
14MP0000350_abnormal_cell_proliferation2.44241717
15MP0004858_abnormal_nervous_system2.42822484
16MP0000858_altered_metastatic_potential2.23576351
17MP0002653_abnormal_ependyma_morphology2.20649133
18MP0008932_abnormal_embryonic_tissue2.10981656
19MP0003121_genomic_imprinting2.08527617
20MP0001697_abnormal_embryo_size2.07532152
21MP0005076_abnormal_cell_differentiation2.07196712
22MP0010352_gastrointestinal_tract_polyps2.06002413
23MP0003191_abnormal_cellular_cholesterol2.03043259
24MP0000537_abnormal_urethra_morphology2.01295318
25MP0010307_abnormal_tumor_latency2.01105094
26MP0008007_abnormal_cellular_replicative1.98906950
27MP0002085_abnormal_embryonic_tissue1.98532126
28MP0008058_abnormal_DNA_repair1.97685840
29MP0003329_amyloid_beta_deposits1.95916251
30MP0002084_abnormal_developmental_patter1.94443387
31MP0009840_abnormal_foam_cell1.91183516
32MP0003119_abnormal_digestive_system1.86384053
33MP0001672_abnormal_embryogenesis/_devel1.86197749
34MP0005380_embryogenesis_phenotype1.86197749
35MP0002080_prenatal_lethality1.76721105
36MP0003566_abnormal_cell_adhesion1.76337434
37MP0005623_abnormal_meninges_morphology1.71673089
38MP0004947_skin_inflammation1.64903517
39MP0010030_abnormal_orbit_morphology1.64366302
40MP0003984_embryonic_growth_retardation1.63828659
41MP0003453_abnormal_keratinocyte_physiol1.61753263
42MP0003300_gastrointestinal_ulcer1.61275854
43MP0002088_abnormal_embryonic_growth/wei1.60049606
44MP0004185_abnormal_adipocyte_glucose1.57323074
45MP0004197_abnormal_fetal_growth/weight/1.55154012
46MP0010234_abnormal_vibrissa_follicle1.50443033
47MP0005025_abnormal_response_to1.48824811
48MP0002086_abnormal_extraembryonic_tissu1.46585407
49MP0005000_abnormal_immune_tolerance1.46189989
50MP0002396_abnormal_hematopoietic_system1.45496168
51MP0005501_abnormal_skin_physiology1.43807484
52MP0000685_abnormal_immune_system1.41588519
53MP0002796_impaired_skin_barrier1.39084318
54MP0003172_abnormal_lysosome_physiology1.37647190
55MP0003861_abnormal_nervous_system1.37626965
56MP0000428_abnormal_craniofacial_morphol1.37594209
57MP0002419_abnormal_innate_immunity1.34948287
58MP0000703_abnormal_thymus_morphology1.34195197
59MP0003091_abnormal_cell_migration1.29117617
60MP0005257_abnormal_intraocular_pressure1.29042756
61MP0001348_abnormal_lacrimal_gland1.26990134
62MP0006072_abnormal_retinal_apoptosis1.26966829
63MP0004133_heterotaxia1.26798375
64MP0000313_abnormal_cell_death1.26633586
65MP0002420_abnormal_adaptive_immunity1.25935819
66MP0003890_abnormal_embryonic-extraembry1.25879299
67MP0001819_abnormal_immune_cell1.25388430
68MP0000604_amyloidosis1.23914424
69MP0006292_abnormal_olfactory_placode1.22986355
70MP0001533_abnormal_skeleton_physiology1.22543175
71MP0004808_abnormal_hematopoietic_stem1.20710684
72MP0004233_abnormal_muscle_weight1.20433146
73MP0002723_abnormal_immune_serum1.19944468
74MP0009053_abnormal_anal_canal1.19536625
75MP0002019_abnormal_tumor_incidence1.19091480
76MP0009333_abnormal_splenocyte_physiolog1.18781915
77MP0005671_abnormal_response_to1.18209224
78MP0003763_abnormal_thymus_physiology1.18179996
79MP0008877_abnormal_DNA_methylation1.17824799
80MP0000678_abnormal_parathyroid_gland1.16152704
81MP0002452_abnormal_antigen_presenting1.14445708
82MP0009785_altered_susceptibility_to1.14264647
83MP0001835_abnormal_antigen_presentation1.14146708
84MP0001800_abnormal_humoral_immune1.12969901
85MP0003122_maternal_imprinting1.10439676
86MP0003567_abnormal_fetal_cardiomyocyte1.10393674
87MP0000733_abnormal_muscle_development1.09699938
88MP0003315_abnormal_perineum_morphology1.08891519
89MP0004264_abnormal_extraembryonic_tissu1.08817606
90MP0003075_altered_response_to1.08479198
91MP0003279_aneurysm1.07638337
92MP0010155_abnormal_intestine_physiology1.06172284
93MP0004885_abnormal_endolymph1.06109624
94MP0000716_abnormal_immune_system1.06004007
95MP0001853_heart_inflammation1.05993744
96MP0009672_abnormal_birth_weight1.05794890
97MP0003786_premature_aging1.05751949
98MP0002429_abnormal_blood_cell1.05237395
99MP0001790_abnormal_immune_system1.02911081
100MP0005387_immune_system_phenotype1.02911081
101MP0002405_respiratory_system_inflammati1.01676977
102MP0002398_abnormal_bone_marrow1.01255692
103MP0004510_myositis1.00940225
104MP0000750_abnormal_muscle_regeneration1.00442554
105MP0003938_abnormal_ear_development0.99696053
106MP0001849_ear_inflammation0.99324103
107MP0000003_abnormal_adipose_tissue0.98891200
108MP0003787_abnormal_imprinting0.98858592
109MP0000490_abnormal_crypts_of0.95889675
110MP0001915_intracranial_hemorrhage0.95507325
111MP0009703_decreased_birth_body0.95398346
112MP0003866_abnormal_defecation0.95002154
113MP0003221_abnormal_cardiomyocyte_apopto0.94816185
114MP0009278_abnormal_bone_marrow0.94616569
115MP0003448_altered_tumor_morphology0.93124198
116MP0008438_abnormal_cutaneous_collagen0.92514602
117MP0002998_abnormal_bone_remodeling0.91824781
118MP0000343_altered_response_to0.91505822
119MP0003303_peritoneal_inflammation0.91204935
120MP0000747_muscle_weakness0.90453098
121MP0002089_abnormal_postnatal_growth/wei0.89640862
122MP0001958_emphysema0.89590070
123MP0002210_abnormal_sex_determination0.88615459
124MP0002163_abnormal_gland_morphology0.88293522
125MP0002111_abnormal_tail_morphology0.87947654
126MP0002722_abnormal_immune_system0.87623950
127MP0001346_abnormal_lacrimal_gland0.87231830
128MP0002249_abnormal_larynx_morphology0.86505153
129MP0002148_abnormal_hypersensitivity_rea0.86374526
130MP0006082_CNS_inflammation0.85921701
131MP0003385_abnormal_body_wall0.83682191
132MP0005394_taste/olfaction_phenotype0.82644957
133MP0005499_abnormal_olfactory_system0.82644957
134MP0003935_abnormal_craniofacial_develop0.82166394
135MP0000049_abnormal_middle_ear0.81920214
136MP0001485_abnormal_pinna_reflex0.81558637
137MP0001845_abnormal_inflammatory_respons0.81076754
138MP0001293_anophthalmia0.80224559
139MP0001145_abnormal_male_reproductive0.80218207
140MP0003115_abnormal_respiratory_system0.79862874
141MP0001727_abnormal_embryo_implantation0.79488172
142MP0000767_abnormal_smooth_muscle0.79345602
143MP0009379_abnormal_foot_pigmentation0.79315008
144MP0000681_abnormal_thyroid_gland0.78881154
145MP0000689_abnormal_spleen_morphology0.78140096
146MP0005375_adipose_tissue_phenotype0.78114778
147MP0002152_abnormal_brain_morphology0.77994763
148MP0003718_maternal_effect0.76713611
149MP0004859_abnormal_synaptic_plasticity0.76648262
150MP0002081_perinatal_lethality0.76079671
151MP0002160_abnormal_reproductive_system0.76036126
152MP0005384_cellular_phenotype0.75661626
153MP0003937_abnormal_limbs/digits/tail_de0.74746226
154MP0001286_abnormal_eye_development0.74327469
155MP0005621_abnormal_cell_physiology0.73227100
156MP0002877_abnormal_melanocyte_morpholog0.72884399
157MP0008789_abnormal_olfactory_epithelium0.72402348
158MP0008770_decreased_survivor_rate0.71760562
159MP0003283_abnormal_digestive_organ0.71286883
160MP0002925_abnormal_cardiovascular_devel0.71026494
161MP0002697_abnormal_eye_size0.69836891
162MP0003942_abnormal_urinary_system0.68655023
163MP0000534_abnormal_ureter_morphology0.67632618
164MP0002751_abnormal_autonomic_nervous0.65306928
165MP0005391_vision/eye_phenotype0.64362481
166MP0002114_abnormal_axial_skeleton0.63156758
167MP0004811_abnormal_neuron_physiology0.62925628

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.54239744
2Selective tooth agenesis (HP:0001592)4.15239103
3Vertebral compression fractures (HP:0002953)3.78720052
4Astrocytoma (HP:0009592)3.29142683
5Abnormality of the astrocytes (HP:0100707)3.29142683
6Patellar aplasia (HP:0006443)3.10736886
7Abnormality of cochlea (HP:0000375)3.03976565
8Abnormality of the labia minora (HP:0012880)3.03172644
9Aplasia/Hypoplasia of the patella (HP:0006498)2.94742727
10Abnormality of the anterior horn cell (HP:0006802)2.92601385
11Degeneration of anterior horn cells (HP:0002398)2.92601385
12Ragged-red muscle fibers (HP:0003200)2.86862062
13Medulloblastoma (HP:0002885)2.85823818
14Eczematoid dermatitis (HP:0000976)2.85441828
15Achilles tendon contracture (HP:0001771)2.82778930
16Broad distal phalanx of finger (HP:0009836)2.79287043
17Adenoma sebaceum (HP:0009720)2.70686875
18Angiofibromas (HP:0010615)2.70686875
19Broad alveolar ridges (HP:0000187)2.66810318
20Neoplasm of striated muscle (HP:0009728)2.64138503
21Cellulitis (HP:0100658)2.61515271
22Insomnia (HP:0100785)2.59739172
23Deep palmar crease (HP:0006191)2.59105082
24Breast hypoplasia (HP:0003187)2.58096537
25Glioma (HP:0009733)2.56524024
26Premature rupture of membranes (HP:0001788)2.55940525
27Hyperacusis (HP:0010780)2.55887530
28Centrally nucleated skeletal muscle fibers (HP:0003687)2.54760639
29Progressive muscle weakness (HP:0003323)2.53906394
30Congenital stationary night blindness (HP:0007642)2.52103740
31Distal lower limb amyotrophy (HP:0008944)2.51864347
32Cerebral hypomyelination (HP:0006808)2.51365701
33Abnormal number of incisors (HP:0011064)2.50314875
34Protrusio acetabuli (HP:0003179)2.49873458
35Basal cell carcinoma (HP:0002671)2.48431288
36Abnormality of the distal phalanges of the toes (HP:0010182)2.47210590
37Abnormality of the Achilles tendon (HP:0005109)2.41362146
38Atrophy/Degeneration involving motor neurons (HP:0007373)2.40894338
39Short 4th metacarpal (HP:0010044)2.40290549
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.40290549
41Morphological abnormality of the inner ear (HP:0011390)2.38435173
42Neoplasm of the heart (HP:0100544)2.37848656
43Renal duplication (HP:0000075)2.36710879
44Neuronal loss in central nervous system (HP:0002529)2.36118771
45Birth length less than 3rd percentile (HP:0003561)2.33833957
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.33653739
47Abnormality of glycolipid metabolism (HP:0010969)2.33653739
48Abnormality of liposaccharide metabolism (HP:0010968)2.33653739
49Distal upper limb amyotrophy (HP:0007149)2.33483969
50Upper limb amyotrophy (HP:0009129)2.33483969
51Distal lower limb muscle weakness (HP:0009053)2.29072455
52Biconcave vertebral bodies (HP:0004586)2.27470158
53Abnormality of macrophages (HP:0004311)2.26657588
54Ulnar bowing (HP:0003031)2.22870231
55Obstructive lung disease (HP:0006536)2.21576170
56Chronic obstructive pulmonary disease (HP:0006510)2.21576170
57Reticulocytopenia (HP:0001896)2.20757036
58Rhabdomyosarcoma (HP:0002859)2.19768411
59Mitral regurgitation (HP:0001653)2.19327550
60Increased connective tissue (HP:0009025)2.16715428
61Abnormality of the lower motor neuron (HP:0002366)2.16688695
62Progressive external ophthalmoplegia (HP:0000590)2.16336940
63Recurrent abscess formation (HP:0002722)2.15175132
64Short nail (HP:0001799)2.14215722
65Hyperparathyroidism (HP:0000843)2.14188741
66Cafe-au-lait spot (HP:0000957)2.13973047
67Interstitial pulmonary disease (HP:0006530)2.11638452
68Pelvic girdle muscle weakness (HP:0003749)2.11357133
69Proximal placement of thumb (HP:0009623)2.10789328
70Dysostosis multiplex (HP:0000943)2.10161147
71Supranuclear gaze palsy (HP:0000605)2.09692199
72Spinal cord lesions (HP:0100561)2.09164833
73Syringomyelia (HP:0003396)2.09164833
74Hypertensive crisis (HP:0100735)2.09009762
75Myopathic facies (HP:0002058)2.07946244
76Cerebral inclusion bodies (HP:0100314)2.07433174
77Atresia of the external auditory canal (HP:0000413)2.06806118
78Thin bony cortex (HP:0002753)2.06500622
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04594635
80Pointed chin (HP:0000307)2.03365526
81Abnormality of chromosome segregation (HP:0002916)2.03090899
82Trismus (HP:0000211)2.03012539
83Increased nuchal translucency (HP:0010880)2.02871599
84Neurofibrillary tangles (HP:0002185)2.02839799
85Pseudobulbar signs (HP:0002200)2.02758062
86Horseshoe kidney (HP:0000085)2.01366722
87Heterotopia (HP:0002282)2.01241922
88Cholecystitis (HP:0001082)1.99753248
89Abnormal gallbladder physiology (HP:0012438)1.99753248
90Neoplasm of the pancreas (HP:0002894)1.99572254
91Deviation of the thumb (HP:0009603)1.99505457
92Microvesicular hepatic steatosis (HP:0001414)1.99473548
93Missing ribs (HP:0000921)1.99433343
94Peripheral hypomyelination (HP:0007182)1.98619013
95Aplasia/Hypoplasia of the sternum (HP:0006714)1.98512607
96Short middle phalanx of the 5th finger (HP:0004220)1.97186673
97Overriding aorta (HP:0002623)1.96941454
98Facial hemangioma (HP:0000329)1.96788486
99Nasal polyposis (HP:0100582)1.96535325
100Abnormality of the nasal mucosa (HP:0000433)1.96259500
101Loss of speech (HP:0002371)1.94438891
102Axonal loss (HP:0003447)1.94342336
103Skin tags (HP:0010609)1.94151617
104Hand muscle atrophy (HP:0009130)1.93897986
105Rib fusion (HP:0000902)1.93655346
106Mediastinal lymphadenopathy (HP:0100721)1.93548422
107Multiple enchondromatosis (HP:0005701)1.93229221
108Upper motor neuron abnormality (HP:0002127)1.91931007
109Rough bone trabeculation (HP:0100670)1.91837280
110Flattened epiphyses (HP:0003071)1.91759690
111Recurrent bacterial skin infections (HP:0005406)1.91177661
112Back pain (HP:0003418)1.91015536
113Abnormality of the alveolar ridges (HP:0006477)1.90942963
114Long palpebral fissure (HP:0000637)1.90658194
115Oral leukoplakia (HP:0002745)1.90193069
116Shoulder girdle muscle weakness (HP:0003547)1.89925838
117Neoplasm of the oral cavity (HP:0100649)1.88789649
118Prominent nose (HP:0000448)1.88518866
119Short 5th finger (HP:0009237)1.86066251
120Absent radius (HP:0003974)1.85162209
121Patellar dislocation (HP:0002999)1.83686896
122Preauricular skin tag (HP:0000384)1.82893844
123Papilloma (HP:0012740)1.81433753
124Verrucae (HP:0200043)1.81433753
125Abnormality of the calcaneus (HP:0008364)1.81206729
126Asymmetry of the thorax (HP:0001555)1.80916101
127Hepatosplenomegaly (HP:0001433)1.79886948
128Growth hormone excess (HP:0000845)1.79815613
129Lower limb amyotrophy (HP:0007210)1.79487485
130Polygenic inheritance (HP:0010982)1.79357412
131Abnormality of the 4th metacarpal (HP:0010012)1.79002769
132Vertebral arch anomaly (HP:0008438)1.78678922
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78663952
134Absent forearm bone (HP:0003953)1.77356463
135Aplasia involving forearm bones (HP:0009822)1.77356463
136Thoracic kyphosis (HP:0002942)1.77092657
137Increased IgE level (HP:0003212)1.77069181
138Hypercortisolism (HP:0001578)1.77002032
139Cervical subluxation (HP:0003308)1.76504323
140Colon cancer (HP:0003003)1.76121814
141Abnormality of the thoracic spine (HP:0100711)1.75651750
142J-shaped sella turcica (HP:0002680)1.74820058
143Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.74557553
144Difficulty climbing stairs (HP:0003551)1.74325541
145Elfin facies (HP:0004428)1.74205723
146Spinal muscular atrophy (HP:0007269)1.74122010
147Amyotrophic lateral sclerosis (HP:0007354)1.73784794
148Anal stenosis (HP:0002025)1.73717339
149Truncus arteriosus (HP:0001660)1.72523572
150Ankle clonus (HP:0011448)1.72429432
151Generalized amyotrophy (HP:0003700)1.72255352
152Flat acetabular roof (HP:0003180)1.71828242
153Shawl scrotum (HP:0000049)1.71059754
154Cerebral aneurysm (HP:0004944)1.70825942
155Hemivertebrae (HP:0002937)1.70809775
156Abnormality of the musculature of the pelvis (HP:0001469)1.70780705
157Abnormality of the hip-girdle musculature (HP:0001445)1.70780705
158Abnormality of oral frenula (HP:0000190)1.70366631
159Ovarian neoplasm (HP:0100615)1.70317140
160Tracheoesophageal fistula (HP:0002575)1.69628117
161Stenosis of the external auditory canal (HP:0000402)1.69100385
162Trigonocephaly (HP:0000243)1.68756375
163Emphysema (HP:0002097)1.68089547
164Hypercalcemia (HP:0003072)1.68053357
165Abnormality of the fingertips (HP:0001211)1.67910773
166Colitis (HP:0002583)1.67662483
167Abnormality of the intervertebral disk (HP:0005108)1.67101279
168Aplasia/Hypoplasia of the uvula (HP:0010293)1.67048337
169Impulsivity (HP:0100710)1.66939236
170Abnormality of skeletal muscle fiber size (HP:0012084)1.66867825
171Turricephaly (HP:0000262)1.65858747
172Absent thumb (HP:0009777)1.65594306
173Esophageal atresia (HP:0002032)1.65207028
174Apathy (HP:0000741)1.65020138
175Fibroma (HP:0010614)1.64318111
176Cellular immunodeficiency (HP:0005374)1.64288584
177Gastrointestinal stroma tumor (HP:0100723)1.64265423
178Increased cerebral lipofuscin (HP:0011813)1.63593452
179Broad face (HP:0000283)1.63505919
180Increased variability in muscle fiber diameter (HP:0003557)1.63356788
181Broad thumb (HP:0011304)1.63266387
182Fibrous tissue neoplasm (HP:0012316)1.62821064
183Gingivitis (HP:0000230)1.62769810
184Calcaneovalgus deformity (HP:0001848)1.62198090
185Abnormality of the umbilical cord (HP:0010881)1.62097769
186Meckel diverticulum (HP:0002245)1.60028405
187Personality changes (HP:0000751)1.59560276
188Spina bifida occulta (HP:0003298)1.59415114
189Orthostatic hypotension (HP:0001278)1.57748792
190Megalocornea (HP:0000485)1.57198531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.34130787
2MAP3K103.69103584
3SMG13.49848673
4BUB13.17369883
5PRPF4B3.07218808
6PKN22.95061814
7ERN12.87605705
8EEF2K2.86579553
9NME22.82715339
10IRAK32.58423837
11NEK22.52426665
12CDK122.48230965
13ARAF2.36140096
14TRIB32.31607616
15WEE12.25621856
16ICK2.00194012
17TESK21.94464992
18SIK11.91756836
19TLK11.89988319
20ALK1.88984532
21PIM21.80883002
22RPS6KB21.80343550
23CDK41.79388958
24NEK11.79147265
25MAP3K131.76383851
26TTK1.74758811
27MAP2K31.69860357
28MAP3K111.68718330
29SRPK11.67398227
30EIF2AK11.59697976
31TSSK61.58894496
32TAOK21.57028204
33MKNK11.56211694
34DYRK31.52904363
35SIK21.47538051
36PLK11.44227650
37LMTK21.41254318
38EPHA21.39390377
39MAP3K81.37745384
40FGFR41.35923843
41BRSK11.33421012
42CDK71.32866065
43PASK1.32818322
44STK101.31433204
45MAP3K91.31206789
46MKNK21.30871815
47RIPK11.29058367
48TYRO31.28215265
49BRAF1.27220408
50UHMK11.25231814
51SCYL21.24570301
52CHEK11.23718219
53GRK61.23710779
54ATR1.20503890
55TBK11.19621198
56LRRK21.15690856
57MAP2K21.11339177
58AURKB1.10427594
59CHEK21.09979028
60MAP3K31.08978411
61PAK41.07182250
62CDK61.06924025
63MAP3K141.06554117
64AURKA1.06215119
65EPHB11.03019742
66PLK31.01161805
67KSR20.99916259
68MAP4K10.99811473
69LATS20.99534640
70KSR10.99307207
71CDK20.98130974
72KDR0.97124445
73RIPK40.90943713
74NTRK10.90299795
75RPS6KA20.84072863
76TAOK10.83502736
77IRAK20.79476172
78SIK30.79113571
79MAP3K10.78774476
80TYK20.78668265
81CSK0.77901990
82MTOR0.77021923
83LIMK10.76305964
84PDGFRA0.76102154
85BRSK20.75410302
86CCNB10.74768933
87RPS6KA40.74153100
88MOS0.73158456
89PDPK10.72520635
90MARK20.70572597
91PLK40.70159020
92CAMKK10.69805038
93PAK10.69786853
94PAK60.69781861
95RPS6KC10.68111919
96RPS6KL10.68111919
97ATM0.68020125
98DYRK1B0.66466603
99PTK20.65608650
100PRKD20.65157040
101CLK10.65070204
102RAF10.64556294
103JAK30.63532184
104CDK10.62816292
105MAPK110.62443619
106MAPKAPK30.61321323
107FES0.60434308
108FGFR10.60307924
109FGFR20.59513543
110CDC42BPA0.59489209
111VRK20.58587799
112CSNK1E0.55472829
113STK40.55415716
114RPS6KA10.54957872
115PRKD30.54376136
116BLK0.54162130
117BRD40.53732615
118CSNK1D0.53378242
119BTK0.52809119
120PRKCI0.52171882
121CDK150.52152777
122BMX0.51073318
123PAK20.50090382
124CDK11A0.49920480
125CDK180.48965617
126DAPK10.46795360
127FLT30.44925268
128PIM10.44436356
129FGR0.43966978
130MAPK90.43757019
131ILK0.43719734
132RET0.43552986
133IKBKE0.43428647
134PDK10.42000772
135PAK30.41993299
136CDK140.41483276
137EIF2AK30.41214546
138RPS6KA60.41057422
139DDR20.40628395
140IRAK40.40443751
141DAPK30.40294653
142CSNK2A20.40050852
143PNCK0.38972949
144AKT20.38841485
145PTK60.38730962
146PRKDC0.38530903
147TESK10.37234326
148TTN0.36675935
149TGFBR10.35555124
150GSK3B0.35305593
151MAPK140.34233749
152ZAP700.33088914

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.72713828
2Spliceosome_Homo sapiens_hsa030403.37690478
3Mismatch repair_Homo sapiens_hsa034303.30277440
4RNA transport_Homo sapiens_hsa030133.06721356
5Base excision repair_Homo sapiens_hsa034102.77701133
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74163092
7Cell cycle_Homo sapiens_hsa041102.63295453
8Other glycan degradation_Homo sapiens_hsa005112.46042041
9mRNA surveillance pathway_Homo sapiens_hsa030152.34879874
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.04439247
11One carbon pool by folate_Homo sapiens_hsa006702.00576982
12RNA polymerase_Homo sapiens_hsa030201.98064536
13Ribosome_Homo sapiens_hsa030101.96871316
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91963859
15Nucleotide excision repair_Homo sapiens_hsa034201.90987063
16Sulfur relay system_Homo sapiens_hsa041221.78664765
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64398819
18Prion diseases_Homo sapiens_hsa050201.57939827
19Oocyte meiosis_Homo sapiens_hsa041141.55330719
20Homologous recombination_Homo sapiens_hsa034401.54410355
21mTOR signaling pathway_Homo sapiens_hsa041501.53947450
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53434834
23Phototransduction_Homo sapiens_hsa047441.52145914
24Galactose metabolism_Homo sapiens_hsa000521.48775391
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47596477
26p53 signaling pathway_Homo sapiens_hsa041151.46840822
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45280668
28Fructose and mannose metabolism_Homo sapiens_hsa000511.44567791
29Osteoclast differentiation_Homo sapiens_hsa043801.40363923
30Chronic myeloid leukemia_Homo sapiens_hsa052201.38425032
31Proteasome_Homo sapiens_hsa030501.38160139
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.38095962
33Salmonella infection_Homo sapiens_hsa051321.36765917
34Pyrimidine metabolism_Homo sapiens_hsa002401.34838448
35RNA degradation_Homo sapiens_hsa030181.30691828
36Colorectal cancer_Homo sapiens_hsa052101.28377141
37Fanconi anemia pathway_Homo sapiens_hsa034601.27965665
38Epstein-Barr virus infection_Homo sapiens_hsa051691.24940532
39Vibrio cholerae infection_Homo sapiens_hsa051101.23657917
40Lysosome_Homo sapiens_hsa041421.22674174
41Viral carcinogenesis_Homo sapiens_hsa052031.22560577
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.21239344
43HTLV-I infection_Homo sapiens_hsa051661.16739423
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16722545
45MicroRNAs in cancer_Homo sapiens_hsa052061.15721661
46Notch signaling pathway_Homo sapiens_hsa043301.15272160
47Antigen processing and presentation_Homo sapiens_hsa046121.11286484
48Endometrial cancer_Homo sapiens_hsa052131.10707487
49Non-small cell lung cancer_Homo sapiens_hsa052231.09656323
50Leishmaniasis_Homo sapiens_hsa051401.09198052
51Hepatitis C_Homo sapiens_hsa051601.08431532
52Thyroid cancer_Homo sapiens_hsa052161.07350827
53Small cell lung cancer_Homo sapiens_hsa052221.05874962
54Non-homologous end-joining_Homo sapiens_hsa034501.04885256
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99649749
56Systemic lupus erythematosus_Homo sapiens_hsa053220.99625335
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96841676
58TNF signaling pathway_Homo sapiens_hsa046680.96379529
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94799545
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94470131
61Hippo signaling pathway_Homo sapiens_hsa043900.91375861
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.90518092
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89285052
64B cell receptor signaling pathway_Homo sapiens_hsa046620.88919354
65VEGF signaling pathway_Homo sapiens_hsa043700.88600788
66Basal cell carcinoma_Homo sapiens_hsa052170.87181021
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.87100293
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.86154515
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85848889
70Glioma_Homo sapiens_hsa052140.85807198
71Tuberculosis_Homo sapiens_hsa051520.84477886
72Acute myeloid leukemia_Homo sapiens_hsa052210.83815088
73Herpes simplex infection_Homo sapiens_hsa051680.82808752
74T cell receptor signaling pathway_Homo sapiens_hsa046600.82325557
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82300228
76Bladder cancer_Homo sapiens_hsa052190.82064886
77Alcoholism_Homo sapiens_hsa050340.81314185
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81043588
79Toxoplasmosis_Homo sapiens_hsa051450.79444446
80Primary immunodeficiency_Homo sapiens_hsa053400.78149136
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76105560
82Viral myocarditis_Homo sapiens_hsa054160.75675926
83Apoptosis_Homo sapiens_hsa042100.74904858
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74322706
85Basal transcription factors_Homo sapiens_hsa030220.74052511
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71214846
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69976258
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.69245065
89Legionellosis_Homo sapiens_hsa051340.68695030
90Renal cell carcinoma_Homo sapiens_hsa052110.68458169
91Biosynthesis of amino acids_Homo sapiens_hsa012300.67375272
92N-Glycan biosynthesis_Homo sapiens_hsa005100.67275667
93Chemokine signaling pathway_Homo sapiens_hsa040620.67268755
94Pancreatic cancer_Homo sapiens_hsa052120.66500357
95Purine metabolism_Homo sapiens_hsa002300.64604381
96Hepatitis B_Homo sapiens_hsa051610.63715129
97Gap junction_Homo sapiens_hsa045400.63678154
98Carbon metabolism_Homo sapiens_hsa012000.62436424
99Proteoglycans in cancer_Homo sapiens_hsa052050.61678603
100HIF-1 signaling pathway_Homo sapiens_hsa040660.60925524
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59819385
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58809857
103Phagosome_Homo sapiens_hsa041450.58605499
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57790479
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.57637844
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57425840
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56586001
108Hedgehog signaling pathway_Homo sapiens_hsa043400.55495139
109Olfactory transduction_Homo sapiens_hsa047400.54786592
110Pathways in cancer_Homo sapiens_hsa052000.54675262
111Synaptic vesicle cycle_Homo sapiens_hsa047210.53470717
112GnRH signaling pathway_Homo sapiens_hsa049120.52940790
113Prostate cancer_Homo sapiens_hsa052150.51880667
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50995281
115Shigellosis_Homo sapiens_hsa051310.50807997
116Pertussis_Homo sapiens_hsa051330.50348565
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50334044
118ErbB signaling pathway_Homo sapiens_hsa040120.49753737
119Estrogen signaling pathway_Homo sapiens_hsa049150.47945455
120Lysine degradation_Homo sapiens_hsa003100.44386749
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43072649
122Tight junction_Homo sapiens_hsa045300.40004278
123Wnt signaling pathway_Homo sapiens_hsa043100.39435693
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39074099
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38931948
126Measles_Homo sapiens_hsa051620.38854852
127Pentose phosphate pathway_Homo sapiens_hsa000300.38658866
128TGF-beta signaling pathway_Homo sapiens_hsa043500.37841342
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.37331337
130Long-term potentiation_Homo sapiens_hsa047200.36468705
131Prolactin signaling pathway_Homo sapiens_hsa049170.35418005
132FoxO signaling pathway_Homo sapiens_hsa040680.34947420
133Endocytosis_Homo sapiens_hsa041440.34886861
134Influenza A_Homo sapiens_hsa051640.34506719
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.34015495
136AMPK signaling pathway_Homo sapiens_hsa041520.33827942
137Insulin signaling pathway_Homo sapiens_hsa049100.33446169
138Choline metabolism in cancer_Homo sapiens_hsa052310.33082721
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.31812192
140MAPK signaling pathway_Homo sapiens_hsa040100.30333643

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