CD300C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to exogenous dsRNA (GO:0071360)6.52612867
2cytoplasmic mRNA processing body assembly (GO:0033962)6.06504084
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.17835611
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.17835611
5modulation by symbiont of host immune response (GO:0052553)5.17835611
6positive regulation by symbiont of host defense response (GO:0052509)5.17835611
7modulation by symbiont of host defense response (GO:0052031)5.17835611
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.17835611
9negative regulation of B cell proliferation (GO:0030889)5.14879986
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.99446474
11negative regulation of cell killing (GO:0031342)4.99446474
12response to peptidoglycan (GO:0032494)4.98189058
13negative regulation of interleukin-12 production (GO:0032695)4.96011835
14DNA replication checkpoint (GO:0000076)4.76037061
15respiratory burst (GO:0045730)4.69626580
16positive regulation of interferon-alpha production (GO:0032727)4.67261435
17defense response to protozoan (GO:0042832)4.65003738
18response to muramyl dipeptide (GO:0032495)4.61907143
19positive regulation of mast cell activation (GO:0033005)4.34659330
20neutrophil activation involved in immune response (GO:0002283)4.33016110
21regulation of interferon-alpha production (GO:0032647)4.32308865
22glycosphingolipid catabolic process (GO:0046479)4.27385663
23response to protozoan (GO:0001562)4.26662405
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.23377476
25immunoglobulin mediated immune response (GO:0016064)4.21131707
26leukocyte aggregation (GO:0070486)4.16842755
27detection of other organism (GO:0098543)4.10215649
28regulation of B cell receptor signaling pathway (GO:0050855)4.06574576
29cellular response to interferon-beta (GO:0035458)3.95971797
30detection of bacterium (GO:0016045)3.88132041
31regulation of interferon-beta biosynthetic process (GO:0045357)3.87554861
32regulation of mast cell activation (GO:0033003)3.87073972
33positive regulation of megakaryocyte differentiation (GO:0045654)3.86811382
34positive regulation of DNA-templated transcription, initiation (GO:2000144)3.84314825
35negative regulation of phagocytosis (GO:0050765)3.83945399
36germinal center formation (GO:0002467)3.81254915
37glycolipid catabolic process (GO:0019377)3.79130909
38macrophage activation involved in immune response (GO:0002281)3.78272622
39interferon-gamma-mediated signaling pathway (GO:0060333)3.76358989
40monoubiquitinated protein deubiquitination (GO:0035520)3.75165728
41attachment of spindle microtubules to kinetochore (GO:0008608)3.74367250
42detection of molecule of bacterial origin (GO:0032490)3.72550038
43antigen processing and presentation of endogenous antigen (GO:0019883)3.70692708
44microglial cell activation (GO:0001774)3.70240787
45positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.68896675
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.64482825
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.64482825
48positive regulation of gamma-delta T cell activation (GO:0046645)3.60006195
49detection of external biotic stimulus (GO:0098581)3.59706809
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.56003028
51positive regulation of interleukin-12 production (GO:0032735)3.52889192
52cellular response to dsRNA (GO:0071359)3.52343056
53regulation of B cell differentiation (GO:0045577)3.51608250
54Arp2/3 complex-mediated actin nucleation (GO:0034314)3.48710855
55production of molecular mediator involved in inflammatory response (GO:0002532)3.47571823
56regulation of gamma-delta T cell activation (GO:0046643)3.46009574
57positive regulation of B cell differentiation (GO:0045579)3.45233159
58positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.42736796
59regulation of T cell tolerance induction (GO:0002664)3.42133259
60cellular response to zinc ion (GO:0071294)3.40827713
61neutrophil mediated immunity (GO:0002446)3.35642364
62ceramide catabolic process (GO:0046514)3.35202377
63negative regulation of B cell activation (GO:0050869)3.34897780
64pinocytosis (GO:0006907)3.34362266
65detection of biotic stimulus (GO:0009595)3.33278698
66B cell mediated immunity (GO:0019724)3.30636400
67mast cell activation (GO:0045576)3.28882508
68regulation of tolerance induction (GO:0002643)3.28842277
69B cell receptor signaling pathway (GO:0050853)3.28122397
70positive regulation of leukocyte degranulation (GO:0043302)3.27529896
71regulation of mast cell degranulation (GO:0043304)3.26564154
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23744139
73response to host immune response (GO:0052572)3.23744139
74regulation of hypersensitivity (GO:0002883)3.22746464
75positive regulation of T cell mediated cytotoxicity (GO:0001916)3.21714571
76neutrophil activation (GO:0042119)3.21639634
77necroptotic process (GO:0070266)3.17301717
78positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16226400
79negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.15775164
80T cell migration (GO:0072678)3.14839258
81negative regulation of lymphocyte mediated immunity (GO:0002707)3.14045893
82regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.13687357
83positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.12833450
84positive regulation of antigen processing and presentation (GO:0002579)3.11698062
85cellular response to type I interferon (GO:0071357)3.10357193
86type I interferon signaling pathway (GO:0060337)3.10357193
87regulation of T-helper 2 cell differentiation (GO:0045628)3.09189199
88regulation of antigen processing and presentation (GO:0002577)3.08515583
89negative regulation of cytokine production involved in immune response (GO:0002719)3.07790316
90negative regulation of alpha-beta T cell activation (GO:0046636)3.07098611
91negative regulation of growth of symbiont in host (GO:0044130)3.06195756
92negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.06195756
93modulation of growth of symbiont involved in interaction with host (GO:0044144)3.06195756
94regulation of growth of symbiont in host (GO:0044126)3.06195756
95response to host (GO:0075136)3.04629800
96response to host defenses (GO:0052200)3.04629800
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.04629800
98negative regulation of T cell mediated immunity (GO:0002710)3.03174462
99response to type I interferon (GO:0034340)3.03037041
100negative regulation of leukocyte mediated immunity (GO:0002704)3.01958628
101myeloid cell activation involved in immune response (GO:0002275)3.01259567
102response to exogenous dsRNA (GO:0043330)2.99934495
103iron ion import (GO:0097286)2.99922511
104cellular extravasation (GO:0045123)2.99495303
105leukocyte degranulation (GO:0043299)2.99357392
106programmed necrotic cell death (GO:0097300)2.98718091
107negative regulation of erythrocyte differentiation (GO:0045647)2.98704265
108regulation of myeloid leukocyte mediated immunity (GO:0002886)2.97960462
109neutrophil chemotaxis (GO:0030593)2.96041177
110regulation of alpha-beta T cell proliferation (GO:0046640)2.94949462
111cellular response to thyroid hormone stimulus (GO:0097067)2.92985186
112positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.92586714
113regulation of regulated secretory pathway (GO:1903305)2.92087710
114myeloid leukocyte activation (GO:0002274)2.91936517
115myoblast migration (GO:0051451)2.90980396
116regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90812964
117T-helper 1 type immune response (GO:0042088)2.90170533
118positive regulation of type 2 immune response (GO:0002830)2.90027704
119regulation of mast cell activation involved in immune response (GO:0033006)2.89640594
120regulation of respiratory burst (GO:0060263)2.89619021
121neutrophil migration (GO:1990266)2.88468123
122lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88416374
123granulocyte activation (GO:0036230)2.87312255
124sphingolipid catabolic process (GO:0030149)2.86959030
125regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.86518937
126regulation of DNA-templated transcription, initiation (GO:2000142)2.85725008
127myeloid dendritic cell activation (GO:0001773)2.85119506
128positive regulation of cellular amide metabolic process (GO:0034250)2.84911038
129myeloid leukocyte mediated immunity (GO:0002444)2.83702203
130regulation of leukocyte degranulation (GO:0043300)2.82107944
131positive regulation of interferon-beta production (GO:0032728)2.81752391
132positive regulation of mast cell degranulation (GO:0043306)2.81368037
133positive regulation of mast cell activation involved in immune response (GO:0033008)2.81368037
134positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.79465707
135regulation of interleukin-12 production (GO:0032655)2.78464196
136negative regulation of innate immune response (GO:0045824)2.77291643
137response to interferon-beta (GO:0035456)2.76666345
138cellular response to interferon-gamma (GO:0071346)2.76521149
139myeloid dendritic cell differentiation (GO:0043011)2.76006641
140regulation of histone phosphorylation (GO:0033127)2.75980879
141positive regulation of chemokine biosynthetic process (GO:0045080)2.75801480
142maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74080746
143macrophage activation (GO:0042116)2.73737973
144regulation of interleukin-17 production (GO:0032660)2.72624262
145negative regulation of myeloid cell apoptotic process (GO:0033033)2.70579919
146NIK/NF-kappaB signaling (GO:0038061)2.68909791
147positive regulation of interleukin-10 production (GO:0032733)2.68117215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.31838624
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.00186577
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.42328329
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.44540159
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.16977860
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.16566590
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.74175546
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.73071651
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.56030102
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.46152744
11SCL_19346495_ChIP-Seq_HPC-7_Human3.30813469
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07973781
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.96746089
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49791623
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46532261
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42921350
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39595858
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32315236
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.27412813
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26775797
21RUNX_20019798_ChIP-Seq_JUKART_Human2.19816015
22* SPI1_23547873_ChIP-Seq_NB4_Human2.17868543
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10951361
24MYB_26560356_Chip-Seq_TH2_Human2.02803675
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00722966
26VDR_21846776_ChIP-Seq_THP-1_Human1.98052598
27SPI1_23127762_ChIP-Seq_K562_Human1.94409027
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89608136
29VDR_24763502_ChIP-Seq_THP-1_Human1.84891930
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.84135128
31MYC_22102868_ChIP-Seq_BL_Human1.82907697
32MYB_26560356_Chip-Seq_TH1_Human1.80581313
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80512882
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79224925
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71641398
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71513601
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69996786
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68888911
39MAF_26560356_Chip-Seq_TH1_Human1.67734875
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65056351
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62623499
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60866945
43* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57883006
44GATA1_22025678_ChIP-Seq_K562_Human1.55568891
45PU_27001747_Chip-Seq_BMDM_Mouse1.54894997
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50993110
47TCF7_22412390_ChIP-Seq_EML_Mouse1.50905227
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.46370344
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45245931
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42171896
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41457308
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39079105
53GATA3_27048872_Chip-Seq_THYMUS_Human1.37628799
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.33741272
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28023014
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27465453
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.26853943
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26514971
59* LXR_22292898_ChIP-Seq_THP-1_Human1.26020682
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25535009
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25496535
62GATA3_26560356_Chip-Seq_TH2_Human1.22667725
63UTX_26944678_Chip-Seq_JUKART_Human1.22553806
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22395488
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21153989
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.20774319
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18650578
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17736084
69GATA1_19941826_ChIP-Seq_K562_Human1.17254395
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13776065
71VDR_24787735_ChIP-Seq_THP-1_Human1.13306946
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13035744
73* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13024762
74BCL6_27268052_Chip-Seq_Bcells_Human1.11946539
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10794310
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08767128
77* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07660041
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07250436
79* BCOR_27268052_Chip-Seq_Bcells_Human1.04711768
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04661699
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03621268
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.03233722
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02887505
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01385108
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00482357
86TFEB_21752829_ChIP-Seq_HELA_Human0.97570563
87* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97393266
88FLI1_27457419_Chip-Seq_LIVER_Mouse0.97187267
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96587337
90* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96527908
91* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95900368
92ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95874267
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.92358985
94ELK1_19687146_ChIP-ChIP_HELA_Human0.91849484
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91716515
96STAT1_20625510_ChIP-Seq_HELA_Human0.90900973
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89457667
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89397322
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.88304746
100SPI1_20517297_ChIP-Seq_HL60_Human0.87577169
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86887271
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85833331
103* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85510123
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83335284
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83101219
106STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83008516
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80427539
108GATA2_19941826_ChIP-Seq_K562_Human0.80197699
109SALL4_22934838_ChIP-ChIP_CD34+_Human0.78271914
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78179220
111ETS1_22383799_ChIP-Seq_G1ME_Mouse0.77767761
112MAF_26560356_Chip-Seq_TH2_Human0.77145423
113NCOR1_26117541_ChIP-Seq_K562_Human0.77110867
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76785680
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.76769187
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76135206
117PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75651245
118* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75250622
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72827334
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.71015079
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.69617821
122KDM2B_26808549_Chip-Seq_DND41_Human0.67416290
123* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67145284
124GATA3_26560356_Chip-Seq_TH1_Human0.66116832
125* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65613622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.35824549
2MP0003724_increased_susceptibility_to3.97921723
3MP0000685_abnormal_immune_system2.90762059
4MP0003436_decreased_susceptibility_to2.90661219
5MP0002396_abnormal_hematopoietic_system2.87469486
6MP0003303_peritoneal_inflammation2.87386639
7MP0002148_abnormal_hypersensitivity_rea2.86139946
8MP0001853_heart_inflammation2.83642929
9MP0004147_increased_porphyrin_level2.73959287
10MP0002419_abnormal_innate_immunity2.72949459
11MP0002452_abnormal_antigen_presenting2.71935893
12MP0001800_abnormal_humoral_immune2.68044530
13MP0005025_abnormal_response_to2.67609845
14MP0001819_abnormal_immune_cell2.48257094
15MP0002723_abnormal_immune_serum2.45297049
16MP0005671_abnormal_response_to2.44444297
17MP0005000_abnormal_immune_tolerance2.39389766
18MP0002876_abnormal_thyroid_physiology2.39079270
19MP0002420_abnormal_adaptive_immunity2.38565847
20MP0009785_altered_susceptibility_to2.36084138
21MP0005464_abnormal_platelet_physiology2.31342692
22MP0009278_abnormal_bone_marrow2.28321363
23MP0002398_abnormal_bone_marrow2.23469500
24MP0001790_abnormal_immune_system2.22244497
25MP0005387_immune_system_phenotype2.22244497
26MP0009840_abnormal_foam_cell2.16904081
27MP0006082_CNS_inflammation2.16542745
28MP0002166_altered_tumor_susceptibility2.15266924
29MP0003191_abnormal_cellular_cholesterol2.09866862
30MP0002006_tumorigenesis2.06186649
31MP0000716_abnormal_immune_system1.99610392
32MP0000689_abnormal_spleen_morphology1.87291160
33MP0000490_abnormal_crypts_of1.69590090
34MP0008057_abnormal_DNA_replication1.68595506
35MP0002429_abnormal_blood_cell1.68174844
36MP0005408_hypopigmentation1.65542692
37MP0010155_abnormal_intestine_physiology1.65258521
38MP0002998_abnormal_bone_remodeling1.64306996
39MP0005451_abnormal_body_composition1.63830190
40MP0002405_respiratory_system_inflammati1.61744648
41MP0003806_abnormal_nucleotide_metabolis1.61171215
42MP0003763_abnormal_thymus_physiology1.60945682
43MP0006054_spinal_hemorrhage1.58976770
44MP0003077_abnormal_cell_cycle1.58305944
45MP0000569_abnormal_digit_pigmentation1.56041425
46MP0001845_abnormal_inflammatory_respons1.55911966
47MP0010094_abnormal_chromosome_stability1.55656354
48MP0002722_abnormal_immune_system1.53564369
49MP0005167_abnormal_blood-brain_barrier1.50461304
50MP0008007_abnormal_cellular_replicative1.47920540
51MP0005075_abnormal_melanosome_morpholog1.45142731
52MP0004510_myositis1.39047534
53MP0000703_abnormal_thymus_morphology1.38992531
54MP0003656_abnormal_erythrocyte_physiolo1.38863143
55MP0008877_abnormal_DNA_methylation1.38383068
56MP0005174_abnormal_tail_pigmentation1.35919224
57MP0008469_abnormal_protein_level1.35087729
58MP0005166_decreased_susceptibility_to1.30888984
59MP0003690_abnormal_glial_cell1.30092045
60MP0005310_abnormal_salivary_gland1.29371107
61MP0009333_abnormal_splenocyte_physiolog1.29329194
62MP0005058_abnormal_lysosome_morphology1.26234598
63MP0009764_decreased_sensitivity_to1.21779659
64MP0001873_stomach_inflammation1.20608461
65MP0006292_abnormal_olfactory_placode1.18940166
66MP0004947_skin_inflammation1.16814393
67MP0004808_abnormal_hematopoietic_stem1.15450831
68MP0008004_abnormal_stomach_pH1.12995701
69MP0004883_abnormal_blood_vessel1.12960264
70MP0008260_abnormal_autophagy1.11291341
71MP0001958_emphysema1.10811153
72MP0003693_abnormal_embryo_hatching1.09944981
73MP0002019_abnormal_tumor_incidence1.05302092
74MP0003111_abnormal_nucleus_morphology1.04572607
75MP0002254_reproductive_system_inflammat1.04145342
76MP0003866_abnormal_defecation1.02451872
77MP0005164_abnormal_response_to1.02252318
78MP0010352_gastrointestinal_tract_polyps0.99659731
79MP0010307_abnormal_tumor_latency0.98912875
80MP0000465_gastrointestinal_hemorrhage0.98192638
81MP0002009_preneoplasia0.97858188
82MP0002139_abnormal_hepatobiliary_system0.95239168
83MP0002090_abnormal_vision0.93764349
84MP0005390_skeleton_phenotype0.92555406
85MP0000858_altered_metastatic_potential0.92527373
86MP0009763_increased_sensitivity_to0.91252077
87MP0000681_abnormal_thyroid_gland0.90643140
88MP0003300_gastrointestinal_ulcer0.89985807
89MP0000343_altered_response_to0.89448091
90MP0002928_abnormal_bile_duct0.86879540
91MP0001851_eye_inflammation0.85573983
92MP0001915_intracranial_hemorrhage0.84424473
93MP0000767_abnormal_smooth_muscle0.82472359
94MP0009765_abnormal_xenobiotic_induced0.81990680
95MP0001533_abnormal_skeleton_physiology0.80024171
96MP0000920_abnormal_myelination0.79479084
97MP0003075_altered_response_to0.78113678
98MP0003787_abnormal_imprinting0.77659290
99MP0002277_abnormal_respiratory_mucosa0.77286298
100MP0003868_abnormal_feces_composition0.76240979
101MP0000604_amyloidosis0.75820332
102MP0003183_abnormal_peptide_metabolism0.75628394
103MP0003795_abnormal_bone_structure0.75353102
104MP0003453_abnormal_keratinocyte_physiol0.74876519
105MP0005397_hematopoietic_system_phenotyp0.74790868
106MP0001545_abnormal_hematopoietic_system0.74790868
107MP0002933_joint_inflammation0.74404857
108MP0003718_maternal_effect0.74355419
109MP0009672_abnormal_birth_weight0.73206844
110MP0000372_irregular_coat_pigmentation0.72638467
111MP0003329_amyloid_beta_deposits0.72414735
112MP0004782_abnormal_surfactant_physiolog0.71059435
113MP0003448_altered_tumor_morphology0.69857717
114MP0000015_abnormal_ear_pigmentation0.67739621
115MP0000371_diluted_coat_color0.67001879
116MP0005084_abnormal_gallbladder_morpholo0.65971842
117MP0001663_abnormal_digestive_system0.65587296
118MP0003172_abnormal_lysosome_physiology0.64437238
119MP0000249_abnormal_blood_vessel0.64194863
120MP0008874_decreased_physiological_sensi0.63313472
121MP0002132_abnormal_respiratory_system0.63252553
122MP0005319_abnormal_enzyme/_coenzyme0.61653284
123MP0001529_abnormal_vocalization0.61150680
124MP0000598_abnormal_liver_morphology0.59731484
125MP0002095_abnormal_skin_pigmentation0.58776973
126MP0001542_abnormal_bone_strength0.58364801
127MP0005647_abnormal_sex_gland0.57991989
128MP0001986_abnormal_taste_sensitivity0.57889486
129MP0001119_abnormal_female_reproductive0.57544502
130MP0005165_increased_susceptibility_to0.56474086
131MP0002332_abnormal_exercise_endurance0.56254110
132MP0003828_pulmonary_edema0.55535360
133MP0005076_abnormal_cell_differentiation0.51623191
134MP0002138_abnormal_hepatobiliary_system0.49785642
135MP0000609_abnormal_liver_physiology0.48389899

Predicted human phenotypes

RankGene SetZ-score
1Spinal cord lesions (HP:0100561)5.66575432
2Syringomyelia (HP:0003396)5.66575432
3Recurrent abscess formation (HP:0002722)5.59505191
4Recurrent bacterial skin infections (HP:0005406)5.52272886
5Absent frontal sinuses (HP:0002688)5.52017086
6Metaphyseal dysplasia (HP:0100255)4.64702305
7Stomatitis (HP:0010280)4.63169496
8Spondylolisthesis (HP:0003302)4.60861787
9Orchitis (HP:0100796)4.55029127
10Retrobulbar optic neuritis (HP:0100654)4.48626379
11Optic neuritis (HP:0100653)4.48626379
12Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.44796585
13Increased neuronal autofluorescent lipopigment (HP:0002074)4.39210129
14Chromsome breakage (HP:0040012)4.18175574
15Obstructive lung disease (HP:0006536)4.17970192
16Chronic obstructive pulmonary disease (HP:0006510)4.17970192
17Increased cerebral lipofuscin (HP:0011813)4.06587907
18Cerebral palsy (HP:0100021)4.00746313
19Testicular atrophy (HP:0000029)3.98600995
20Vacuolated lymphocytes (HP:0001922)3.85912739
21Dysostosis multiplex (HP:0000943)3.82162409
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.76433592
23Amyloidosis (HP:0011034)3.71833422
24Short middle phalanx of the 5th finger (HP:0004220)3.65962360
25Abnormality of lateral ventricle (HP:0030047)3.64921116
26Mediastinal lymphadenopathy (HP:0100721)3.59074417
27Abnormality of the frontal sinuses (HP:0002687)3.52160050
28Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47264439
29Abnormality of liposaccharide metabolism (HP:0010968)3.45475706
30Abnormality of glycosphingolipid metabolism (HP:0004343)3.45475706
31Abnormality of glycolipid metabolism (HP:0010969)3.45475706
32Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.43670644
33Systemic lupus erythematosus (HP:0002725)3.33391834
34Loss of speech (HP:0002371)3.26423252
35Parakeratosis (HP:0001036)3.22735398
36Myositis (HP:0100614)3.19320893
37Recurrent skin infections (HP:0001581)3.14371850
38Agnosia (HP:0010524)3.14098935
39Keratoconjunctivitis sicca (HP:0001097)3.09045465
40Meningitis (HP:0001287)3.04978858
41Urticaria (HP:0001025)3.04793501
42Keratoconjunctivitis (HP:0001096)3.02453121
43Abnormality of the phalanges of the 2nd finger (HP:0009541)3.02136396
44Autoimmune thrombocytopenia (HP:0001973)3.02100078
45Eczematoid dermatitis (HP:0000976)2.98954093
46Disinhibition (HP:0000734)2.97717096
47Abnormality of the pleura (HP:0002103)2.97621991
48Duplicated collecting system (HP:0000081)2.96959968
49Encephalitis (HP:0002383)2.91969142
50Short 5th finger (HP:0009237)2.88307530
51Recurrent viral infections (HP:0004429)2.87581674
52Papilledema (HP:0001085)2.87148428
53Chronic otitis media (HP:0000389)2.85528561
54Thrombocytosis (HP:0001894)2.85096306
55Abnormality of polysaccharide metabolism (HP:0011012)2.81460968
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.81460968
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.81460968
58Gastrointestinal infarctions (HP:0005244)2.81104521
59Acrocyanosis (HP:0001063)2.80293782
60Diminished motivation (HP:0000745)2.79560431
61Mutism (HP:0002300)2.78341728
62Petechiae (HP:0000967)2.74544242
63Apathy (HP:0000741)2.74385508
64Recurrent gram-negative bacterial infections (HP:0005420)2.68581596
65Delayed CNS myelination (HP:0002188)2.67698838
66Abnormality of the parietal bone (HP:0002696)2.67395281
67T lymphocytopenia (HP:0005403)2.64869228
68Abnormality of the renal collecting system (HP:0004742)2.63901296
69Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.62916406
70Hemoptysis (HP:0002105)2.61813788
71Renal cortical cysts (HP:0000803)2.60436026
72Purpura (HP:0000979)2.59933353
73Mucopolysacchariduria (HP:0008155)2.59046103
74Urinary glycosaminoglycan excretion (HP:0003541)2.59046103
75Vasculitis (HP:0002633)2.58772562
76Neonatal respiratory distress (HP:0002643)2.57259255
77Arthropathy (HP:0003040)2.55862484
78Elevated erythrocyte sedimentation rate (HP:0003565)2.55372532
79Spontaneous hematomas (HP:0007420)2.55255022
80Prolonged bleeding time (HP:0003010)2.50004463
81Abnormality of macrophages (HP:0004311)2.49415015
82Abnormality of complement system (HP:0005339)2.48913806
83Leukocytosis (HP:0001974)2.47336745
84Episodic fever (HP:0001954)2.46745571
85Abnormality of T cell number (HP:0011839)2.41142239
86Chest pain (HP:0100749)2.39776874
87Arterial thrombosis (HP:0004420)2.37872343
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.37674447
89Abnormality of pyrimidine metabolism (HP:0004353)2.36350074
90Increased IgE level (HP:0003212)2.35951353
91Reticulocytopenia (HP:0001896)2.35412691
92Epistaxis (HP:0000421)2.32197249
93Pulmonary embolism (HP:0002204)2.32148818
94Gangrene (HP:0100758)2.31426255
95Flared metaphyses (HP:0003015)2.30866515
96Abnormality of the vasculature of the conjunctiva (HP:0008054)2.30563490
97Recurrent fungal infections (HP:0002841)2.30218290
98Cellulitis (HP:0100658)2.28661696
99Lower limb hyperreflexia (HP:0002395)2.28453937
100Anorexia (HP:0002039)2.27592957
101Upper motor neuron abnormality (HP:0002127)2.27518885
102Polyneuropathy (HP:0001271)2.26784872
103Hepatosplenomegaly (HP:0001433)2.26392549
104Inflammation of the large intestine (HP:0002037)2.21298534
105Hematochezia (HP:0002573)2.20284845
106Exertional dyspnea (HP:0002875)2.18211092
107Abnormality of iron homeostasis (HP:0011031)2.18147993
108Gingival bleeding (HP:0000225)2.16699331
109Hypoplastic iliac wings (HP:0002866)2.16092349
110Abnormality of DNA repair (HP:0003254)2.12469823
111Abnormality of T cells (HP:0002843)2.11411554
112Axonal loss (HP:0003447)2.11276292
113Progressive neurologic deterioration (HP:0002344)2.10719600
114Mucosal telangiectasiae (HP:0100579)2.09299194
115Neuronal loss in central nervous system (HP:0002529)2.09116172
116Gastrointestinal inflammation (HP:0004386)2.07644903
117Emphysema (HP:0002097)2.07214186
118Interstitial pulmonary disease (HP:0006530)2.07097328
119Osteomyelitis (HP:0002754)2.06384645
120Poor head control (HP:0002421)2.06322742
121Clubbing of toes (HP:0100760)2.05555503
122Nephritis (HP:0000123)2.05313126
123Vertigo (HP:0002321)2.05306640
124Delayed closure of the anterior fontanelle (HP:0001476)2.04886971
125Increased IgM level (HP:0003496)2.04660596
126Skin rash (HP:0000988)2.04046995
127Xerostomia (HP:0000217)2.04034326
128Neurofibrillary tangles (HP:0002185)2.03808704
129Colitis (HP:0002583)2.03403595
130Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.03102300
131IgM deficiency (HP:0002850)2.01966204
132Glomerulonephritis (HP:0000099)2.01412747
133Ascites (HP:0001541)2.00914521
134Prostate neoplasm (HP:0100787)1.99745681
135Gastrointestinal stroma tumor (HP:0100723)1.97440537
136Abnormality of transition element cation homeostasis (HP:0011030)1.97206654
137Abnormality of the prostate (HP:0008775)1.97019002
138Panhypogammaglobulinemia (HP:0003139)1.96871535
139Recurrent pneumonia (HP:0006532)1.96339889
140Azoospermia (HP:0000027)1.93712865
141Thickened calvaria (HP:0002684)1.91847167
142Granulocytopenia (HP:0001913)1.91819332
143Myocardial infarction (HP:0001658)1.91328720
144Restrictive lung disease (HP:0002091)1.91295636
145Glomerulopathy (HP:0100820)1.91001001
146Hypergammaglobulinemia (HP:0010702)1.87565529
147Abnormality of the 2nd finger (HP:0004100)1.85232523
148Arthralgia (HP:0002829)1.84180522
149Abnormal platelet volume (HP:0011876)1.83669576
150Abnormal delayed hypersensitivity skin test (HP:0002963)1.82888355
151Pulmonary infiltrates (HP:0002113)1.82039817
152Pustule (HP:0200039)1.81745744
153Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.78880458
154Chronic mucocutaneous candidiasis (HP:0002728)1.78859295
155Recurrent cutaneous fungal infections (HP:0011370)1.78859295
156Nasal polyposis (HP:0100582)1.77381634
157Pulmonary fibrosis (HP:0002206)1.77013511
158Supernumerary ribs (HP:0005815)1.76517156
159Gingivitis (HP:0000230)1.76240289
160Increased serum ferritin (HP:0003281)1.75458358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.98499796
2MAP4K13.80988989
3BRSK23.58343247
4KIT3.46865709
5FLT33.43110780
6CSF1R3.39975244
7TRPM73.02784508
8IRAK42.91940623
9SCYL22.54627044
10MAP3K132.35527434
11MAP3K142.28001912
12FGR2.27412985
13BLK2.26822463
14TBK12.23550409
15TYK22.17027474
16BMPR22.15849719
17STK242.05113314
18MAP3K62.04987143
19CSK1.90691967
20BRSK11.82527124
21MARK31.82306685
22MAP3K111.80525204
23JAK31.80202416
24MAP3K31.78757484
25GRK71.74043648
26ERN11.73670887
27RIPK41.65093106
28IRAK31.54483366
29TGFBR21.51374826
30TNK21.50612003
31IKBKB1.47779758
32MAP3K11.39672817
33NME21.38983376
34PKN11.36620025
35FES1.36099110
36STK38L1.32847578
37IKBKE1.28542134
38TEC1.27188118
39MAP3K81.26928635
40MOS1.25362289
41ARAF1.18379078
42STK101.14879309
43MAP3K121.11178904
44SIK31.10403626
45ITK1.06457865
46TAOK11.06150202
47GRK61.05669648
48CLK11.05092209
49CDK91.03716439
50SYK1.01919010
51TESK21.01080557
52EPHB10.98278377
53PIM20.97127542
54RPS6KA60.93507654
55PDK10.93184286
56PIM10.93166353
57LYN0.92273701
58SGK20.91268791
59RPS6KA40.83047297
60CHEK20.80284036
61TAOK20.78839816
62PIK3CG0.78086950
63ATR0.77172941
64MAPK120.77103940
65PLK30.74416304
66HCK0.74182085
67CDC42BPA0.73322788
68MAP3K50.70980985
69MUSK0.70922223
70STK30.69790144
71CHUK0.69781128
72PRKD20.69098372
73LCK0.67985569
74MAPK70.66225724
75TTK0.65316291
76MELK0.65238958
77DDR20.64533690
78BTK0.64042766
79EEF2K0.63158913
80CAMKK20.63113485
81MATK0.62393075
82STK110.61881948
83MARK20.59918912
84IRAK20.59820736
85RPS6KC10.59122977
86RPS6KL10.59122977
87PLK40.59122571
88ZAP700.57624944
89ACVR1B0.56914204
90ABL10.56813332
91MAP2K60.56129217
92SIK20.55404058
93JAK10.55003039
94HIPK20.54752470
95SGK30.54619902
96FYN0.53940714
97CDK190.53193291
98KSR20.53161846
99MAP2K20.51215494
100IRAK10.51019189
101ADRBK20.50353465
102MAP4K20.49992859
103RIPK10.49815067
104JAK20.49317132
105MAPK130.48132637
106DAPK20.47558779
107PDPK10.47088288
108LRRK20.43634617
109NLK0.42807175
110PLK10.42726653
111STK40.42672636
112DYRK1B0.41474971
113PRKCD0.41469051
114CDK60.41324312
115CAMK1D0.39004811
116MAPKAPK20.38763137
117RPS6KA20.38653112
118CDC70.38466885
119DMPK0.38045168
120ZAK0.37219304
121MAP2K30.35017431
122SGK2230.34623200
123SGK4940.34623200
124YES10.34370502
125PRKG20.34041174
126MAPK40.33589106
127NUAK10.31795810
128ATM0.31618836
129RAF10.29200549
130PAK40.29087850
131VRK10.28713055
132PRPF4B0.27796387
133TXK0.27713681
134ABL20.27364982
135RPS6KB20.27019721
136INSR0.26418751
137RPS6KA10.25805598
138ERBB40.25534517
139AURKB0.25109229
140PRKCQ0.24667438
141PTK2B0.24190717
142MAPK30.23978955
143EGFR0.21357915
144PAK10.20433992

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.28821316
2DNA replication_Homo sapiens_hsa030302.60662092
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.59573187
4Leishmaniasis_Homo sapiens_hsa051402.52558345
5Autoimmune thyroid disease_Homo sapiens_hsa053202.46292097
6B cell receptor signaling pathway_Homo sapiens_hsa046622.36217649
7RNA degradation_Homo sapiens_hsa030182.36053798
8Rheumatoid arthritis_Homo sapiens_hsa053232.33340779
9Antigen processing and presentation_Homo sapiens_hsa046122.25417222
10Base excision repair_Homo sapiens_hsa034102.17684013
11Pertussis_Homo sapiens_hsa051332.09840190
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.08180347
13Type I diabetes mellitus_Homo sapiens_hsa049402.08065062
14Herpes simplex infection_Homo sapiens_hsa051682.07296154
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.06434211
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98548543
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.97938927
18Shigellosis_Homo sapiens_hsa051311.93373147
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.91159725
20Osteoclast differentiation_Homo sapiens_hsa043801.86962500
21Tuberculosis_Homo sapiens_hsa051521.86038886
22Cell cycle_Homo sapiens_hsa041101.84734531
23Chemokine signaling pathway_Homo sapiens_hsa040621.79468902
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76474424
25Staphylococcus aureus infection_Homo sapiens_hsa051501.72029840
26Lysosome_Homo sapiens_hsa041421.63893219
27Mismatch repair_Homo sapiens_hsa034301.62084046
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60300485
29Influenza A_Homo sapiens_hsa051641.59789142
30Measles_Homo sapiens_hsa051621.52766830
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.51686034
32Pancreatic cancer_Homo sapiens_hsa052121.49829338
33Primary immunodeficiency_Homo sapiens_hsa053401.49681389
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49161579
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44726231
36Fanconi anemia pathway_Homo sapiens_hsa034601.44112809
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.42941139
38Hepatitis B_Homo sapiens_hsa051611.35253822
39Salmonella infection_Homo sapiens_hsa051321.34106107
40Homologous recombination_Homo sapiens_hsa034401.30441868
41Viral myocarditis_Homo sapiens_hsa054161.28282073
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.27738952
43Toxoplasmosis_Homo sapiens_hsa051451.26239541
44Platelet activation_Homo sapiens_hsa046111.17703556
45Apoptosis_Homo sapiens_hsa042101.16994204
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12890066
47Other glycan degradation_Homo sapiens_hsa005111.12302606
48Legionellosis_Homo sapiens_hsa051341.12156074
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10302517
50TNF signaling pathway_Homo sapiens_hsa046681.08312849
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06226745
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05779429
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98676929
54Hematopoietic cell lineage_Homo sapiens_hsa046400.98428144
55Ovarian steroidogenesis_Homo sapiens_hsa049130.97254120
56Epstein-Barr virus infection_Homo sapiens_hsa051690.93072929
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91803152
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.91448145
59Fatty acid elongation_Homo sapiens_hsa000620.90586245
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.90170370
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88082390
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87026419
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.85675697
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.85369516
65Phagosome_Homo sapiens_hsa041450.84632855
66Oocyte meiosis_Homo sapiens_hsa041140.84194430
67Hepatitis C_Homo sapiens_hsa051600.84042549
68p53 signaling pathway_Homo sapiens_hsa041150.81898955
69Basal transcription factors_Homo sapiens_hsa030220.81058192
70Collecting duct acid secretion_Homo sapiens_hsa049660.80447127
71Acute myeloid leukemia_Homo sapiens_hsa052210.80414735
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79222136
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75436091
74Graft-versus-host disease_Homo sapiens_hsa053320.72635580
75Malaria_Homo sapiens_hsa051440.72497711
76Viral carcinogenesis_Homo sapiens_hsa052030.70838729
77Amoebiasis_Homo sapiens_hsa051460.68481083
78MicroRNAs in cancer_Homo sapiens_hsa052060.66549743
79VEGF signaling pathway_Homo sapiens_hsa043700.65991890
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65165453
81Chronic myeloid leukemia_Homo sapiens_hsa052200.64931079
82Colorectal cancer_Homo sapiens_hsa052100.64510319
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63800931
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60800497
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58782320
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.58521171
87Adherens junction_Homo sapiens_hsa045200.56148828
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.56043693
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52960440
90GnRH signaling pathway_Homo sapiens_hsa049120.52771027
91Vitamin B6 metabolism_Homo sapiens_hsa007500.52656006
92Small cell lung cancer_Homo sapiens_hsa052220.52119908
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.51238658
94T cell receptor signaling pathway_Homo sapiens_hsa046600.50978599
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50063018
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49646344
97Prion diseases_Homo sapiens_hsa050200.48925074
98Bladder cancer_Homo sapiens_hsa052190.48919081
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48491169
100Nucleotide excision repair_Homo sapiens_hsa034200.48375515
101Non-small cell lung cancer_Homo sapiens_hsa052230.47431652
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47307771
103Lysine degradation_Homo sapiens_hsa003100.46683590
104African trypanosomiasis_Homo sapiens_hsa051430.44903351
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44370026
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41955931
107Complement and coagulation cascades_Homo sapiens_hsa046100.41245532
108Endocytosis_Homo sapiens_hsa041440.40740712
109Regulation of autophagy_Homo sapiens_hsa041400.40647486
110ABC transporters_Homo sapiens_hsa020100.40064870
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.38664183
112Allograft rejection_Homo sapiens_hsa053300.38575192
113MAPK signaling pathway_Homo sapiens_hsa040100.37420201
114HTLV-I infection_Homo sapiens_hsa051660.34869504
115HIF-1 signaling pathway_Homo sapiens_hsa040660.31343563
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29577103
117Tryptophan metabolism_Homo sapiens_hsa003800.29532477
118Prolactin signaling pathway_Homo sapiens_hsa049170.29110210
119Pentose phosphate pathway_Homo sapiens_hsa000300.28884634
120Systemic lupus erythematosus_Homo sapiens_hsa053220.28839045
121Ether lipid metabolism_Homo sapiens_hsa005650.27968950
122Notch signaling pathway_Homo sapiens_hsa043300.27721106
123Renal cell carcinoma_Homo sapiens_hsa052110.27494133
124Asthma_Homo sapiens_hsa053100.27039132
125Type II diabetes mellitus_Homo sapiens_hsa049300.26047064
126Mineral absorption_Homo sapiens_hsa049780.24841245
127Insulin resistance_Homo sapiens_hsa049310.21375801
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20904792
129Sphingolipid metabolism_Homo sapiens_hsa006000.20479898
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.20416451
131Galactose metabolism_Homo sapiens_hsa000520.18736498
132Vibrio cholerae infection_Homo sapiens_hsa051100.17602728
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17425936
134Renin-angiotensin system_Homo sapiens_hsa046140.15919839

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