CD300E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)6.41404480
2positive regulation of gamma-delta T cell activation (GO:0046645)5.83931570
3negative regulation of interleukin-12 production (GO:0032695)5.74396279
4L-phenylalanine catabolic process (GO:0006559)5.74288124
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.74288124
6L-phenylalanine metabolic process (GO:0006558)5.48337515
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.48337515
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.37789803
9negative regulation of cell killing (GO:0031342)5.37789803
10neutrophil activation involved in immune response (GO:0002283)5.27452480
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.22022902
12macrophage activation involved in immune response (GO:0002281)5.14243899
13aromatic amino acid family catabolic process (GO:0009074)5.10642583
14complement activation, alternative pathway (GO:0006957)5.00188507
15plasma lipoprotein particle clearance (GO:0034381)4.98386214
16cellular extravasation (GO:0045123)4.96746225
17alpha-linolenic acid metabolic process (GO:0036109)4.92061162
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.87985529
19peptidyl-glutamic acid carboxylation (GO:0017187)4.84207371
20protein carboxylation (GO:0018214)4.84207371
21detection of other organism (GO:0098543)4.82722054
22detection of molecule of bacterial origin (GO:0032490)4.81776507
23bile acid biosynthetic process (GO:0006699)4.70784730
24regulation of protein activation cascade (GO:2000257)4.64401374
25kynurenine metabolic process (GO:0070189)4.52541144
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51803373
27cysteine metabolic process (GO:0006534)4.51141762
28negative regulation of fibrinolysis (GO:0051918)4.50754376
29indole-containing compound catabolic process (GO:0042436)4.49292882
30indolalkylamine catabolic process (GO:0046218)4.49292882
31tryptophan catabolic process (GO:0006569)4.49292882
32urea cycle (GO:0000050)4.44231097
33urea metabolic process (GO:0019627)4.44231097
34high-density lipoprotein particle remodeling (GO:0034375)4.39619829
35regulation of complement activation (GO:0030449)4.37979152
36detection of bacterium (GO:0016045)4.35528286
37tryptophan metabolic process (GO:0006568)4.31006860
38aldehyde catabolic process (GO:0046185)4.30233096
39glyoxylate metabolic process (GO:0046487)4.29125468
40low-density lipoprotein particle clearance (GO:0034383)4.27727330
41positive regulation of mast cell activation (GO:0033005)4.24768027
42leukocyte aggregation (GO:0070486)4.23070378
43regulation of gamma-delta T cell activation (GO:0046643)4.22843908
44regulation of fibrinolysis (GO:0051917)4.21133234
45sulfur amino acid catabolic process (GO:0000098)4.20592917
46regulation of triglyceride catabolic process (GO:0010896)4.20492558
47microglial cell activation (GO:0001774)4.19934541
48detection of external biotic stimulus (GO:0098581)4.18548781
49macrophage activation (GO:0042116)4.17611028
50lipopolysaccharide-mediated signaling pathway (GO:0031663)4.15902945
51neutrophil mediated immunity (GO:0002446)4.08041581
52detection of biotic stimulus (GO:0009595)4.05697345
53nitrogen cycle metabolic process (GO:0071941)4.03869903
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.02506472
55bile acid metabolic process (GO:0008206)4.01219791
56modulation by symbiont of host defense response (GO:0052031)3.97088531
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.97088531
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.97088531
59positive regulation by organism of defense response of other organism involved in symbiotic interact3.97088531
60modulation by symbiont of host immune response (GO:0052553)3.97088531
61positive regulation by symbiont of host defense response (GO:0052509)3.97088531
62respiratory burst (GO:0045730)3.96261866
63immunoglobulin mediated immune response (GO:0016064)3.89758371
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.88833708
65response to host immune response (GO:0052572)3.88833708
66neutrophil activation (GO:0042119)3.87549695
67reverse cholesterol transport (GO:0043691)3.86862985
68cofactor catabolic process (GO:0051187)3.83415014
69regulation of mast cell degranulation (GO:0043304)3.82044386
70plasma lipoprotein particle remodeling (GO:0034369)3.81749051
71protein-lipid complex remodeling (GO:0034368)3.81749051
72macromolecular complex remodeling (GO:0034367)3.81749051
73granulocyte activation (GO:0036230)3.76346013
74regulation of mast cell activation (GO:0033003)3.75991284
75response to muramyl dipeptide (GO:0032495)3.74665928
76regulation of B cell receptor signaling pathway (GO:0050855)3.73741725
77regulation of dendritic cell antigen processing and presentation (GO:0002604)3.73028796
78negative regulation of T cell mediated immunity (GO:0002710)3.72209111
79positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.70039769
80myeloid cell activation involved in immune response (GO:0002275)3.69165492
81regulation of cholesterol esterification (GO:0010872)3.67981689
82amino-acid betaine metabolic process (GO:0006577)3.67543457
83negative regulation of sterol transport (GO:0032372)3.65090535
84negative regulation of cholesterol transport (GO:0032375)3.65090535
85phospholipid efflux (GO:0033700)3.65088746
86positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.64492257
87regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.63604427
88cholesterol efflux (GO:0033344)3.63497915
89antigen processing and presentation of endogenous antigen (GO:0019883)3.61266950
90tyrosine metabolic process (GO:0006570)3.60652292
91aromatic amino acid family metabolic process (GO:0009072)3.59701344
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.56943656
93positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.56020180
94response to host (GO:0075136)3.55996841
95response to host defenses (GO:0052200)3.55996841
96response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.55996841
97fibrinolysis (GO:0042730)3.55894259
98complement activation, classical pathway (GO:0006958)3.54828730
99regulation of mast cell activation involved in immune response (GO:0033006)3.54492447
100positive regulation of mast cell activation involved in immune response (GO:0033008)3.54211263
101positive regulation of mast cell degranulation (GO:0043306)3.54211263
102triglyceride homeostasis (GO:0070328)3.52566651
103acylglycerol homeostasis (GO:0055090)3.52566651
104complement activation (GO:0006956)3.51500692
105serine family amino acid catabolic process (GO:0009071)3.51170096
106regulation of tolerance induction (GO:0002643)3.49420712
107positive regulation of cellular amide metabolic process (GO:0034250)3.49416257
108positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.45595073
109negative regulation of lymphocyte mediated immunity (GO:0002707)3.44424285
110regulation of cholesterol storage (GO:0010885)3.43513694
111positive regulation of lipid catabolic process (GO:0050996)3.43375225
112regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.43347373
113regulation of T cell tolerance induction (GO:0002664)3.42877945
114myeloid leukocyte mediated immunity (GO:0002444)3.41981135
115positive regulation of lipoprotein lipase activity (GO:0051006)3.41690673
116positive regulation of triglyceride lipase activity (GO:0061365)3.41690673
117bile acid and bile salt transport (GO:0015721)3.40970158
118defense response to protozoan (GO:0042832)3.40599316
119negative regulation of erythrocyte differentiation (GO:0045647)3.39817320
120regulation of interferon-beta biosynthetic process (GO:0045357)3.39634747
121homocysteine metabolic process (GO:0050667)3.39300063
122lysine metabolic process (GO:0006553)3.35871722
123lysine catabolic process (GO:0006554)3.35871722
124protein activation cascade (GO:0072376)3.33959301
125killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.33472720
126disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.33472720
127regulation of myeloid leukocyte mediated immunity (GO:0002886)3.33000761
128regulation of cholesterol homeostasis (GO:2000188)3.32124925
129antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.31171082
130imidazole-containing compound metabolic process (GO:0052803)3.29917737
131positive regulation of type 2 immune response (GO:0002830)3.29453767
132plasma lipoprotein particle assembly (GO:0034377)3.29436882
133alpha-amino acid catabolic process (GO:1901606)3.28579314
134regulation of leukocyte degranulation (GO:0043300)3.24451512
135cellular ketone body metabolic process (GO:0046950)3.23424126
136positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.21557467
137response to protozoan (GO:0001562)3.20901340
138primary alcohol catabolic process (GO:0034310)3.20551115
139glutamate metabolic process (GO:0006536)3.19998767
140positive regulation of interleukin-1 beta secretion (GO:0050718)3.19871646
141dicarboxylic acid biosynthetic process (GO:0043650)3.19483687
142neutrophil chemotaxis (GO:0030593)3.17857415
143cellular modified amino acid catabolic process (GO:0042219)3.17248783
144regulation of T-helper 2 cell differentiation (GO:0045628)3.17037666
145acute-phase response (GO:0006953)3.16596744
146regulation of vitamin D biosynthetic process (GO:0060556)3.16259119
147ethanol oxidation (GO:0006069)3.15435106
148cellular glucuronidation (GO:0052695)3.14872422
149production of molecular mediator involved in inflammatory response (GO:0002532)3.14124408
150arginine metabolic process (GO:0006525)3.12260063
151lipoprotein metabolic process (GO:0042157)3.11167526
152hydrogen peroxide biosynthetic process (GO:0050665)3.11095384
153negative regulation of leukocyte mediated immunity (GO:0002704)3.10996316
154indolalkylamine metabolic process (GO:0006586)3.10858180
155low-density lipoprotein particle remodeling (GO:0034374)3.10069541
156interferon-gamma-mediated signaling pathway (GO:0060333)3.10052128
157negative regulation of interleukin-1 beta production (GO:0032691)3.09933588
158neutrophil migration (GO:1990266)3.09675179
159cholesterol homeostasis (GO:0042632)3.09529439
160lipoprotein transport (GO:0042953)3.08502195
161negative regulation of cytokine production involved in immune response (GO:0002719)3.08479183
162protein-lipid complex assembly (GO:0065005)3.08126013
163glycine metabolic process (GO:0006544)3.08015254
164negative regulation of interleukin-1 production (GO:0032692)3.06647515
165regulation of antigen processing and presentation (GO:0002577)3.06350593
166uronic acid metabolic process (GO:0006063)3.05950693
167glucuronate metabolic process (GO:0019585)3.05950693
168sterol homeostasis (GO:0055092)3.04137582
169regulation of interleukin-17 production (GO:0032660)3.04023887
170cellular amino acid catabolic process (GO:0009063)3.03279167
171negative regulation of interleukin-17 production (GO:0032700)3.01975614
172germinal center formation (GO:0002467)3.01857484
173heme transport (GO:0015886)3.01369756
174plasma lipoprotein particle organization (GO:0071827)3.00957854
175interferon-gamma production (GO:0032609)2.99776666
176T-helper 1 type immune response (GO:0042088)2.98965928
177positive regulation of interleukin-1 secretion (GO:0050716)2.98795264
178myeloid leukocyte activation (GO:0002274)2.98425493
179antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.97173436
180positive regulation of tolerance induction (GO:0002645)2.96631753
181positive regulation of antigen processing and presentation (GO:0002579)2.96293082
182negative regulation of myeloid cell apoptotic process (GO:0033033)2.94737682
183B cell mediated immunity (GO:0019724)2.94474271
184cytokine secretion (GO:0050663)2.92613383
185positive regulation of NF-kappaB import into nucleus (GO:0042346)2.92126386
186regulation of interleukin-1 beta secretion (GO:0050706)2.91943959
187positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.90693938
188regulation of interleukin-8 biosynthetic process (GO:0045414)2.88009251
189leukocyte migration involved in inflammatory response (GO:0002523)2.86922565
190T cell migration (GO:0072678)2.86085872
191positive regulation of chemokine biosynthetic process (GO:0045080)2.85779713
192regulation of macrophage cytokine production (GO:0010935)2.85767046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.91586524
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.28217993
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.47043497
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.98289031
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.89469474
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.95827142
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.84021781
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.80351748
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.71620539
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.59052710
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.01502474
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.89410380
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.84058750
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.74740111
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65615631
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48392869
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39206029
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.28715519
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19408148
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18596119
21GATA1_22025678_ChIP-Seq_K562_Human2.06259688
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03767296
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03010997
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86448554
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85645653
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84639188
27* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81431099
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77399505
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77189723
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75529196
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69719991
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.69447840
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.67207662
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63549231
35TCF7_22412390_ChIP-Seq_EML_Mouse1.59769594
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.59147974
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58560187
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54188322
39CLOCK_20551151_ChIP-Seq_293T_Human1.51754873
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48903256
41GATA3_27048872_Chip-Seq_THYMUS_Human1.41589129
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36006308
43PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34231893
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31717906
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31665758
46* KDM2B_26808549_Chip-Seq_DND41_Human1.31495399
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29757992
48MAF_26560356_Chip-Seq_TH2_Human1.28638854
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27748201
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26146667
51GATA3_26560356_Chip-Seq_TH2_Human1.25701688
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.25256960
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24483446
54SCL_19346495_ChIP-Seq_HPC-7_Human1.21736594
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21732001
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19872226
57E2F7_22180533_ChIP-Seq_HELA_Human1.18794695
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18725310
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16004666
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14011710
61LXR_22292898_ChIP-Seq_THP-1_Human1.11775237
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11710146
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11610113
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11572391
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11440160
66GATA1_19941826_ChIP-Seq_K562_Human1.11402913
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09408013
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07785744
69SPI1_23127762_ChIP-Seq_K562_Human1.07201710
70PU_27001747_Chip-Seq_BMDM_Mouse1.06294624
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05326237
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03188025
73VDR_21846776_ChIP-Seq_THP-1_Human1.02007843
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01741433
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01017964
76HNF4A_19822575_ChIP-Seq_HepG2_Human0.98021963
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96981894
78RUNX1_22412390_ChIP-Seq_EML_Mouse0.96657176
79GATA2_19941826_ChIP-Seq_K562_Human0.95068621
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94736338
81SPI1_23547873_ChIP-Seq_NB4_Human0.94561593
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94456663
83ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93454861
84EGR1_19032775_ChIP-ChIP_M12_Human0.93071511
85* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92417243
86VDR_24763502_ChIP-Seq_THP-1_Human0.91693465
87MAF_26560356_Chip-Seq_TH1_Human0.91417978
88RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90452523
89KDM2B_26808549_Chip-Seq_JURKAT_Human0.90066444
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90047477
91STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89888374
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88952700
93VDR_24787735_ChIP-Seq_THP-1_Human0.88450854
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87447913
95RUNX_20019798_ChIP-Seq_JUKART_Human0.86619593
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.85737877
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85046887
98GATA4_25053715_ChIP-Seq_YYC3_Human0.82783605
99* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82398258
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.81686022
101* HTT_18923047_ChIP-ChIP_STHdh_Human0.80005306
102MYB_26560356_Chip-Seq_TH1_Human0.79771160
103MYB_26560356_Chip-Seq_TH2_Human0.79263476
104GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78379076
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.77758197
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77684375
107BCL6_27268052_Chip-Seq_Bcells_Human0.77525753
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.77237900
109GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77229286
110SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76071178
111UTX_26944678_Chip-Seq_JUKART_Human0.75730188
112* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.74716174
113RXRA_24833708_ChIP-Seq_LIVER_Mouse0.74293866
114* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73840664
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.73516888
116* BCOR_27268052_Chip-Seq_Bcells_Human0.73303465
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.72812745
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72424605
119RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72375139
120FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.71821061
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.71644547
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71608473
123MYC_22102868_ChIP-Seq_BL_Human0.70961583
124SPI1_20517297_ChIP-Seq_HL60_Human0.70654553
125* STAT1_20625510_ChIP-Seq_HELA_Human0.69784388
126* SMRT_27268052_Chip-Seq_Bcells_Human0.69470617
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68829146
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68462835
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.67320973
130NCOR1_26117541_ChIP-Seq_K562_Human0.66184492
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65920501
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65920501
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.65834785
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.65293952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.89528553
2MP0005360_urolithiasis5.59519448
3MP0005365_abnormal_bile_salt4.47755321
4MP0005085_abnormal_gallbladder_physiolo4.40785447
5MP0008875_abnormal_xenobiotic_pharmacok3.72903213
6MP0009840_abnormal_foam_cell3.66481773
7MP0005083_abnormal_biliary_tract3.59349840
8MP0003195_calcinosis3.34614513
9MP0005058_abnormal_lysosome_morphology2.98347006
10MP0003806_abnormal_nucleotide_metabolis2.90273079
11MP0010329_abnormal_lipoprotein_level2.77497106
12MP0003252_abnormal_bile_duct2.70292625
13MP0003191_abnormal_cellular_cholesterol2.59961423
14MP0003436_decreased_susceptibility_to2.53671910
15MP0003303_peritoneal_inflammation2.49592830
16MP0000604_amyloidosis2.19456860
17MP0003828_pulmonary_edema2.18296600
18MP0005332_abnormal_amino_acid1.99888473
19MP0001835_abnormal_antigen_presentation1.98120197
20MP0000609_abnormal_liver_physiology1.92358579
21MP0003656_abnormal_erythrocyte_physiolo1.86465336
22MP0002419_abnormal_innate_immunity1.81126172
23MP0003172_abnormal_lysosome_physiology1.79418115
24MP0010155_abnormal_intestine_physiology1.72053296
25MP0008260_abnormal_autophagy1.71030109
26MP0006082_CNS_inflammation1.68981425
27MP0009785_altered_susceptibility_to1.68463585
28MP0001666_abnormal_nutrient_absorption1.67780741
29MP0002998_abnormal_bone_remodeling1.67582232
30MP0002138_abnormal_hepatobiliary_system1.63040705
31MP0005319_abnormal_enzyme/_coenzyme1.63015915
32MP0002118_abnormal_lipid_homeostasis1.61667446
33MP0009764_decreased_sensitivity_to1.55928520
34MP0008469_abnormal_protein_level1.54689294
35MP0000858_altered_metastatic_potential1.48835227
36MP0003300_gastrointestinal_ulcer1.48173416
37MP0009333_abnormal_splenocyte_physiolog1.46396571
38MP0002398_abnormal_bone_marrow1.46095660
39MP0005464_abnormal_platelet_physiology1.43270770
40MP0005025_abnormal_response_to1.42903948
41MP0005310_abnormal_salivary_gland1.42188411
42MP0003186_abnormal_redox_activity1.40503836
43MP0005000_abnormal_immune_tolerance1.40342056
44MP0005387_immune_system_phenotype1.38718387
45MP0001790_abnormal_immune_system1.38718387
46MP0008004_abnormal_stomach_pH1.37594664
47MP0005584_abnormal_enzyme/coenzyme_acti1.37437348
48MP0000465_gastrointestinal_hemorrhage1.34146441
49MP0001800_abnormal_humoral_immune1.34071998
50MP0009763_increased_sensitivity_to1.33161545
51MP0003763_abnormal_thymus_physiology1.30325852
52MP0003724_increased_susceptibility_to1.30243266
53MP0005451_abnormal_body_composition1.29814022
54MP0003690_abnormal_glial_cell1.29630651
55MP0002132_abnormal_respiratory_system1.28842240
56MP0004019_abnormal_vitamin_homeostasis1.23966748
57MP0003705_abnormal_hypodermis_morpholog1.23701846
58MP0001764_abnormal_homeostasis1.22758322
59MP0004947_skin_inflammation1.22386067
60MP0009643_abnormal_urine_homeostasis1.22180307
61MP0001845_abnormal_inflammatory_respons1.22172629
62MP0001533_abnormal_skeleton_physiology1.21381866
63MP0003183_abnormal_peptide_metabolism1.21009506
64MP0002452_abnormal_antigen_presenting1.18468891
65MP0000598_abnormal_liver_morphology1.18401408
66MP0003075_altered_response_to1.16376335
67MP0004510_myositis1.15595101
68MP0006054_spinal_hemorrhage1.11972829
69MP0002723_abnormal_immune_serum1.10977473
70MP0000685_abnormal_immune_system1.06264265
71MP0002277_abnormal_respiratory_mucosa1.02211244
72MP0001851_eye_inflammation1.00324909
73MP0005166_decreased_susceptibility_to1.00310079
74MP0009278_abnormal_bone_marrow0.97862749
75MP0003868_abnormal_feces_composition0.94507554
76MP0000343_altered_response_to0.93614368
77MP0001545_abnormal_hematopoietic_system0.93404706
78MP0005397_hematopoietic_system_phenotyp0.93404706
79MP0005390_skeleton_phenotype0.92864198
80MP0002166_altered_tumor_susceptibility0.92023892
81MP0003866_abnormal_defecation0.90568173
82MP0002148_abnormal_hypersensitivity_rea0.90253535
83MP0001819_abnormal_immune_cell0.90159365
84MP0002420_abnormal_adaptive_immunity0.89867816
85MP0002332_abnormal_exercise_endurance0.87569290
86MP0001663_abnormal_digestive_system0.86519017
87MP0000689_abnormal_spleen_morphology0.85736847
88MP0003011_delayed_dark_adaptation0.85287476
89MP0001853_heart_inflammation0.84399381
90MP0000703_abnormal_thymus_morphology0.83749409
91MP0003453_abnormal_keratinocyte_physiol0.81554356
92MP0009642_abnormal_blood_homeostasis0.79692506
93MP0000920_abnormal_myelination0.79345137
94MP0003329_amyloid_beta_deposits0.78346898
95MP0009697_abnormal_copulation0.77484998
96MP0002254_reproductive_system_inflammat0.76345001
97MP0005671_abnormal_response_to0.74475798
98MP0002405_respiratory_system_inflammati0.74087127
99MP0009765_abnormal_xenobiotic_induced0.73477204
100MP0002136_abnormal_kidney_physiology0.73299560
101MP0003566_abnormal_cell_adhesion0.73294649
102MP0003795_abnormal_bone_structure0.72076586
103MP0005076_abnormal_cell_differentiation0.71546703
104MP0005376_homeostasis/metabolism_phenot0.71106013
105MP0008873_increased_physiological_sensi0.70243589
106MP0002090_abnormal_vision0.69800567
107MP0005636_abnormal_mineral_homeostasis0.69534265
108MP0004782_abnormal_surfactant_physiolog0.69290433
109MP0004883_abnormal_blood_vessel0.68959215
110MP0005023_abnormal_wound_healing0.68446109
111MP0000716_abnormal_immune_system0.68200883
112MP0005164_abnormal_response_to0.67434350
113MP0000249_abnormal_blood_vessel0.66439512
114MP0003448_altered_tumor_morphology0.66366552
115MP0000569_abnormal_digit_pigmentation0.64781188
116MP0008874_decreased_physiological_sensi0.63973772
117MP0010307_abnormal_tumor_latency0.63789272
118MP0002933_joint_inflammation0.63511252
119MP0004130_abnormal_muscle_cell0.63121654
120MP0004808_abnormal_hematopoietic_stem0.61815144
121MP0003091_abnormal_cell_migration0.61483146
122MP0002971_abnormal_brown_adipose0.61305489
123MP0002006_tumorigenesis0.60906926
124MP0003221_abnormal_cardiomyocyte_apopto0.60584369
125MP0001756_abnormal_urination0.60034577
126MP0001873_stomach_inflammation0.59757297
127MP0005334_abnormal_fat_pad0.58869676
128MP0005167_abnormal_blood-brain_barrier0.58474062
129MP0002078_abnormal_glucose_homeostasis0.57862646
130MP0004381_abnormal_hair_follicle0.57479905
131MP0003045_fibrosis0.56962006
132MP0002722_abnormal_immune_system0.56315779
133MP0002429_abnormal_blood_cell0.56214647
134MP0004484_altered_response_of0.54517612
135MP0000371_diluted_coat_color0.54285380
136MP0002009_preneoplasia0.51101665
137MP0005535_abnormal_body_temperature0.50724539

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.95340534
2Orchitis (HP:0100796)5.94770293
3Optic neuritis (HP:0100653)5.94748922
4Retrobulbar optic neuritis (HP:0100654)5.94748922
5Deep venous thrombosis (HP:0002625)5.79432297
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.75754580
7Stomatitis (HP:0010280)5.65127000
8Complement deficiency (HP:0004431)5.57475233
9Intrahepatic cholestasis (HP:0001406)5.32167147
10Xanthomatosis (HP:0000991)5.26271477
11Recurrent gram-negative bacterial infections (HP:0005420)5.21877633
12Elevated erythrocyte sedimentation rate (HP:0003565)5.13814970
13Systemic lupus erythematosus (HP:0002725)4.99713261
14Abnormality of monocarboxylic acid metabolism (HP:0010996)4.75280610
15Prolonged partial thromboplastin time (HP:0003645)4.52565104
16Abnormality of complement system (HP:0005339)4.50201223
17Hyperlipoproteinemia (HP:0010980)4.47194181
18Hypobetalipoproteinemia (HP:0003563)4.42469851
19Vacuolated lymphocytes (HP:0001922)4.16768005
20Keratoconjunctivitis sicca (HP:0001097)4.14667455
21Joint hemorrhage (HP:0005261)4.12825939
22Glomerulonephritis (HP:0000099)4.04086550
23Recurrent fungal infections (HP:0002841)3.96325794
24Keratoconjunctivitis (HP:0001096)3.84367014
25Abnormality of the common coagulation pathway (HP:0010990)3.64225461
26Gastrointestinal infarctions (HP:0005244)3.62212731
27Epidermoid cyst (HP:0200040)3.60685368
28Obstructive lung disease (HP:0006536)3.60263352
29Chronic obstructive pulmonary disease (HP:0006510)3.60263352
30Eczematoid dermatitis (HP:0000976)3.58393172
31Hypercholesterolemia (HP:0003124)3.58132400
32Vasculitis (HP:0002633)3.54984024
33Abnormality of glycolipid metabolism (HP:0010969)3.47685721
34Abnormality of liposaccharide metabolism (HP:0010968)3.47685721
35Abnormality of glycosphingolipid metabolism (HP:0004343)3.47685721
36Meningitis (HP:0001287)3.46050599
37Chronic mucocutaneous candidiasis (HP:0002728)3.45824676
38Recurrent cutaneous fungal infections (HP:0011370)3.45824676
39Hypolipoproteinemia (HP:0010981)3.45761811
40Episodic fever (HP:0001954)3.45593801
41Hemoptysis (HP:0002105)3.41957799
42Myocardial infarction (HP:0001658)3.39951901
43Encephalitis (HP:0002383)3.37907524
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.35258550
45Pulmonary infiltrates (HP:0002113)3.30503410
46Recurrent abscess formation (HP:0002722)3.30328887
47Increased cerebral lipofuscin (HP:0011813)3.28511458
48Recurrent bacterial skin infections (HP:0005406)3.26273245
49Dysostosis multiplex (HP:0000943)3.21937733
50Hyperammonemia (HP:0001987)3.20704059
51Hypoalphalipoproteinemia (HP:0003233)3.20196119
52Arterial thrombosis (HP:0004420)3.18177234
53Fat malabsorption (HP:0002630)3.18150080
54Abnormality of glutamine family amino acid metabolism (HP:0010902)3.07934557
55Leukocytosis (HP:0001974)3.05719689
56Abnormality of sulfur amino acid metabolism (HP:0004339)3.04115953
57Recurrent viral infections (HP:0004429)3.03391384
58Increased neuronal autofluorescent lipopigment (HP:0002074)3.01989698
59Ketosis (HP:0001946)2.98330577
60Gangrene (HP:0100758)2.93861411
61Abnormality of the intrinsic pathway (HP:0010989)2.90655320
62Esophageal varix (HP:0002040)2.88001026
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.86590730
64Axonal loss (HP:0003447)2.83127695
65Amyloidosis (HP:0011034)2.77190452
66Hematochezia (HP:0002573)2.76986925
67Loss of speech (HP:0002371)2.75613517
68Chest pain (HP:0100749)2.73915743
69Hyperglycinemia (HP:0002154)2.73854689
70Abnormality of methionine metabolism (HP:0010901)2.72472062
71Prolonged bleeding time (HP:0003010)2.70940090
72Hypoglycemic coma (HP:0001325)2.67352905
73Abnormality of the vasculature of the conjunctiva (HP:0008054)2.67035268
74Abnormality of macrophages (HP:0004311)2.65479169
75Anorexia (HP:0002039)2.64684190
76Increased IgE level (HP:0003212)2.64124146
77Abnormality of the lumbar spine (HP:0100712)2.63603137
78Skin nodule (HP:0200036)2.62449709
79Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62045715
80Nephritis (HP:0000123)2.60179195
81Mucopolysacchariduria (HP:0008155)2.58183341
82Urinary glycosaminoglycan excretion (HP:0003541)2.58183341
83T lymphocytopenia (HP:0005403)2.56834384
84Steatorrhea (HP:0002570)2.55843865
85Conjunctival telangiectasia (HP:0000524)2.54124448
86Abnormality of pyrimidine metabolism (HP:0004353)2.53998551
87Hepatocellular carcinoma (HP:0001402)2.53622515
88Cellulitis (HP:0100658)2.52188283
89Spastic diplegia (HP:0001264)2.51841870
90Thoracic kyphosis (HP:0002942)2.50067832
91Hypochromic microcytic anemia (HP:0004840)2.49562781
92Polyneuropathy (HP:0001271)2.48895250
93Gingival bleeding (HP:0000225)2.48004846
94Abnormality of T cell number (HP:0011839)2.47226474
95Vertigo (HP:0002321)2.45991096
96Abnormality of polysaccharide metabolism (HP:0011012)2.43962803
97Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43962803
98Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43962803
99Abnormality of nucleobase metabolism (HP:0010932)2.43778687
100Petechiae (HP:0000967)2.41960854
101Upper motor neuron abnormality (HP:0002127)2.40149075
102Epistaxis (HP:0000421)2.39794460
103Abnormality of purine metabolism (HP:0004352)2.38668754
104Abnormality of serine family amino acid metabolism (HP:0010894)2.36861576
105Abnormality of glycine metabolism (HP:0010895)2.36861576
106Abnormality of the pleura (HP:0002103)2.34429981
107Disinhibition (HP:0000734)2.32730990
108Spontaneous abortion (HP:0005268)2.31302097
109Urticaria (HP:0001025)2.31168356
110Increased IgM level (HP:0003496)2.30685394
111Conjugated hyperbilirubinemia (HP:0002908)2.29860102
112Hyperglycinuria (HP:0003108)2.29775459
113Hyperbilirubinemia (HP:0002904)2.29760151
114Mitral stenosis (HP:0001718)2.28887616
115Malnutrition (HP:0004395)2.28733610
116Osteomyelitis (HP:0002754)2.25482227
117Recurrent skin infections (HP:0001581)2.23252850
118Inflammation of the large intestine (HP:0002037)2.22620756
119Purpura (HP:0000979)2.22552557
120Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21030954
121Abnormality of fatty-acid metabolism (HP:0004359)2.20400408
122Sensorimotor neuropathy (HP:0007141)2.20388348
123Thrombophlebitis (HP:0004418)2.20364057
124Pustule (HP:0200039)2.20240632
125Abnormality of the endocardium (HP:0004306)2.20043315
126Spontaneous hematomas (HP:0007420)2.19744216
127Polycythemia (HP:0001901)2.18911128
128Abnormality of iron homeostasis (HP:0011031)2.14256611
129Glomerulopathy (HP:0100820)2.13902674
130Pulmonary embolism (HP:0002204)2.13366885
131Colitis (HP:0002583)2.12352650
132Cholelithiasis (HP:0001081)2.10791032
133Abnormal gallbladder morphology (HP:0012437)2.09850396
134Acne (HP:0001061)2.09726568
135Abnormality of T cells (HP:0002843)2.09142580
136Gastrointestinal inflammation (HP:0004386)2.08444047
137Gingivitis (HP:0000230)2.08378976
138Keratitis (HP:0000491)2.08377353
139Amaurosis fugax (HP:0100576)2.04167516
140Sepsis (HP:0100806)2.04112366
141Ketoacidosis (HP:0001993)2.02556510
142Autoimmune thrombocytopenia (HP:0001973)1.99699449
143Mutism (HP:0002300)1.96651323
144Menorrhagia (HP:0000132)1.96600219
145Granulocytopenia (HP:0001913)1.96015750
146Abnormality of transition element cation homeostasis (HP:0011030)1.94856567
147Autoimmune hemolytic anemia (HP:0001890)1.94480837
148Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93688314
149Neuronal loss in central nervous system (HP:0002529)1.93514505
150Memory impairment (HP:0002354)1.92115252
151Increased serum ferritin (HP:0003281)1.90960876
152Cheilitis (HP:0100825)1.90764974
153Abnormality of the pericardium (HP:0001697)1.90506389
154Arthralgia (HP:0002829)1.89193750
155Irritability (HP:0000737)1.88990081
156Peripheral demyelination (HP:0011096)1.86959622
157Periodontitis (HP:0000704)1.86377445
158Premature loss of primary teeth (HP:0006323)1.86149544
159Hypergammaglobulinemia (HP:0010702)1.86031868
160Abnormal gallbladder physiology (HP:0012438)1.85687632
161Cholecystitis (HP:0001082)1.85687632
162Eosinophilia (HP:0001880)1.84966841
163Mediastinal lymphadenopathy (HP:0100721)1.83668035
164Abnormality of the peritoneum (HP:0002585)1.82732710
165Global brain atrophy (HP:0002283)1.82072691
166Abnormality of the gallbladder (HP:0005264)1.81028466
167Fatigue (HP:0012378)1.80345278
168Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79283196
169Hemorrhage of the eye (HP:0011885)1.79243233
170Acanthocytosis (HP:0001927)1.77564441
171Peritonitis (HP:0002586)1.77412926
172Vascular calcification (HP:0004934)1.77340147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.54495123
2TYK23.26639325
3TBK12.90115885
4NME22.75687556
5PRPF4B2.71827978
6FGFR42.70755085
7STK102.70162843
8CSF1R2.66722292
9BCKDK2.46358824
10TGFBR22.37095293
11PKN22.23934582
12FES2.14681413
13MAP4K12.13069739
14BLK2.07951264
15TAOK32.03950462
16IRAK41.95054535
17KIT1.94366060
18RIPK41.92392308
19CSK1.87859865
20STK241.84431862
21FGR1.83294191
22BMPR21.79363990
23MAP3K131.66885006
24TRIB31.65458572
25PIK3CG1.61265516
26JAK11.59256982
27RPS6KA41.54578648
28MAP3K141.54573197
29TNK21.52871863
30TAOK11.47237397
31LRRK21.46917015
32JAK21.45783839
33SIK11.42334455
34ERBB41.41926115
35CAMK1D1.41626980
36MAP2K31.35139984
37IKBKE1.35122337
38EPHB11.33770320
39JAK31.33138847
40KSR21.32315819
41IRAK31.31753567
42IRAK21.31364323
43FLT31.28581349
44IRAK11.25998673
45TTN1.23251629
46DAPK21.19172811
47DYRK1B1.18890131
48GRK61.15197536
49KDR1.09631275
50SYK1.08582440
51SIK31.08463585
52HCK1.08213067
53MATK1.07128719
54ZAP701.06536887
55PTK61.05284907
56RIPK11.04767012
57PBK1.03568556
58MAPK111.01801837
59LYN1.01124105
60NEK91.00185687
61CDK60.99458112
62MAP3K30.98799648
63EGFR0.91587562
64CDC42BPA0.88447279
65CAMK1G0.87781853
66MAPK70.84350023
67LCK0.83753213
68IKBKB0.82648263
69ABL20.78352076
70TAOK20.78187740
71TEC0.77936832
72DDR20.77537503
73YES10.76787212
74MOS0.76213706
75MAP3K80.75215433
76MAPK40.74692752
77MARK20.67765130
78GRK70.64002986
79NEK10.62891501
80PRKCD0.61025234
81PRKCQ0.60541086
82CDK40.59344122
83MAP3K50.58293288
84BTK0.57328258
85EPHA30.56595980
86MAP3K20.55721360
87CAMKK20.55350312
88PRKACG0.54766359
89MAP3K10.53598945
90PDK10.53392764
91IGF1R0.53070632
92KSR10.52695950
93MAP2K40.52673591
94MARK30.52182382
95FYN0.52175246
96ARAF0.51080960
97CHUK0.49241816
98PRKD20.48376055
99ABL10.48021678
100INSRR0.46449457
101SIK20.46391224
102ITK0.45300227
103GSK3A0.45217338
104TESK20.44870220
105PDPK10.44526652
106SGK30.44461163
107RPS6KL10.42934367
108RPS6KC10.42934367
109PIM10.42651369
110STK38L0.42628630
111PRKCH0.40667768
112MAP3K100.40001926
113CAMKK10.39469945
114FGFR30.39397606
115MST1R0.39100243
116CDC70.38349125
117RPS6KA60.37103251
118MAP3K60.36474322
119TYRO30.35980165
120TXK0.35885554
121SCYL20.34621850
122PDGFRB0.34493420
123MAP3K110.34483320
124MAP3K90.34366577
125MAPK120.34346741
126RAF10.31447359
127ADRBK20.30953011
128MAP2K10.29859068
129PDK20.29282368
130ACVR1B0.28939077
131MAP3K70.28523020
132DAPK30.28497888
133HIPK20.28124191
134SGK20.27639067
135STK110.25581950

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.34137812
2Staphylococcus aureus infection_Homo sapiens_hsa051503.78303125
3Nitrogen metabolism_Homo sapiens_hsa009103.65033040
4Complement and coagulation cascades_Homo sapiens_hsa046103.32490471
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24012740
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.08922622
7Arginine biosynthesis_Homo sapiens_hsa002202.90675993
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.67587032
9Graft-versus-host disease_Homo sapiens_hsa053322.49600199
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46616778
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34012369
12Tryptophan metabolism_Homo sapiens_hsa003802.30976634
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26492926
14Allograft rejection_Homo sapiens_hsa053302.18617834
15Fatty acid degradation_Homo sapiens_hsa000712.16306288
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.15888810
17Rheumatoid arthritis_Homo sapiens_hsa053232.08193463
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98792455
19Caffeine metabolism_Homo sapiens_hsa002321.92452037
20Histidine metabolism_Homo sapiens_hsa003401.91038302
21Autoimmune thyroid disease_Homo sapiens_hsa053201.89385777
22Type I diabetes mellitus_Homo sapiens_hsa049401.87907550
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84545714
24Peroxisome_Homo sapiens_hsa041461.79021018
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.76717440
26Hematopoietic cell lineage_Homo sapiens_hsa046401.72788795
27Asthma_Homo sapiens_hsa053101.67509166
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.66991688
29PPAR signaling pathway_Homo sapiens_hsa033201.63567026
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.62201919
31Chemical carcinogenesis_Homo sapiens_hsa052041.61191270
32Chemokine signaling pathway_Homo sapiens_hsa040621.60234102
33Folate biosynthesis_Homo sapiens_hsa007901.57853244
34beta-Alanine metabolism_Homo sapiens_hsa004101.55717739
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55123068
36Fatty acid metabolism_Homo sapiens_hsa012121.54579760
37Butanoate metabolism_Homo sapiens_hsa006501.50134678
38Selenocompound metabolism_Homo sapiens_hsa004501.41886245
39Bile secretion_Homo sapiens_hsa049761.40689462
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.40258008
41Phenylalanine metabolism_Homo sapiens_hsa003601.35278471
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33202610
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31471125
44T cell receptor signaling pathway_Homo sapiens_hsa046601.28512738
45Herpes simplex infection_Homo sapiens_hsa051681.27477103
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27455447
47Viral myocarditis_Homo sapiens_hsa054161.25140129
48Propanoate metabolism_Homo sapiens_hsa006401.25128639
49Retinol metabolism_Homo sapiens_hsa008301.23642971
50ABC transporters_Homo sapiens_hsa020101.22546181
51Acute myeloid leukemia_Homo sapiens_hsa052211.19099847
52Primary immunodeficiency_Homo sapiens_hsa053401.18926100
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.18382972
54Starch and sucrose metabolism_Homo sapiens_hsa005001.17565550
55Steroid biosynthesis_Homo sapiens_hsa001001.17096508
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16888263
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15341156
58Hepatitis B_Homo sapiens_hsa051611.13135697
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10054442
60Tyrosine metabolism_Homo sapiens_hsa003501.07977026
61Fatty acid elongation_Homo sapiens_hsa000621.07795136
62Lysosome_Homo sapiens_hsa041421.07572384
63Leishmaniasis_Homo sapiens_hsa051401.07073446
64Sulfur relay system_Homo sapiens_hsa041221.06795195
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.98950270
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94455014
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.93705098
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90712034
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90289175
70Biosynthesis of amino acids_Homo sapiens_hsa012300.88861662
71Platelet activation_Homo sapiens_hsa046110.87168701
72Carbon metabolism_Homo sapiens_hsa012000.86940300
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86505518
74Pertussis_Homo sapiens_hsa051330.85318987
75Sulfur metabolism_Homo sapiens_hsa009200.85046427
76Pyruvate metabolism_Homo sapiens_hsa006200.83333609
77Prion diseases_Homo sapiens_hsa050200.82961009
78Pentose phosphate pathway_Homo sapiens_hsa000300.79898548
79Apoptosis_Homo sapiens_hsa042100.79696553
80Osteoclast differentiation_Homo sapiens_hsa043800.78145589
81Fat digestion and absorption_Homo sapiens_hsa049750.77332468
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77038174
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.76375472
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75285805
85B cell receptor signaling pathway_Homo sapiens_hsa046620.75281392
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72026546
87VEGF signaling pathway_Homo sapiens_hsa043700.71492165
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69434446
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68965692
90Bladder cancer_Homo sapiens_hsa052190.68741901
91Arginine and proline metabolism_Homo sapiens_hsa003300.68682062
92Prolactin signaling pathway_Homo sapiens_hsa049170.68324723
93Non-small cell lung cancer_Homo sapiens_hsa052230.67406473
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.66861720
95Lysine degradation_Homo sapiens_hsa003100.64470266
96Dorso-ventral axis formation_Homo sapiens_hsa043200.64341873
97Other glycan degradation_Homo sapiens_hsa005110.63214184
98Pancreatic cancer_Homo sapiens_hsa052120.62551679
99Renal cell carcinoma_Homo sapiens_hsa052110.61915551
100HIF-1 signaling pathway_Homo sapiens_hsa040660.61299476
101Notch signaling pathway_Homo sapiens_hsa043300.60197228
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.60060642
103Chronic myeloid leukemia_Homo sapiens_hsa052200.59619308
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59560095
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59251425
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59125716
107Type II diabetes mellitus_Homo sapiens_hsa049300.58832161
108Vitamin digestion and absorption_Homo sapiens_hsa049770.58046454
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57432893
110Epstein-Barr virus infection_Homo sapiens_hsa051690.57023474
111GnRH signaling pathway_Homo sapiens_hsa049120.55966735
112Legionellosis_Homo sapiens_hsa051340.55854670
113Phagosome_Homo sapiens_hsa041450.55169834
114Mineral absorption_Homo sapiens_hsa049780.53612884
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.53351858
116Malaria_Homo sapiens_hsa051440.52482042
117Tuberculosis_Homo sapiens_hsa051520.49411009
118Glutathione metabolism_Homo sapiens_hsa004800.47210950
119Collecting duct acid secretion_Homo sapiens_hsa049660.47195190
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46066984
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46013737
122Endocytosis_Homo sapiens_hsa041440.45930563
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45704559
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45122678
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.44769867
126MAPK signaling pathway_Homo sapiens_hsa040100.44740076
127Glycerolipid metabolism_Homo sapiens_hsa005610.44343562
128FoxO signaling pathway_Homo sapiens_hsa040680.44309463
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43385944
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.43357570
131One carbon pool by folate_Homo sapiens_hsa006700.40156909
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36162041
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.35883615
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35713186
135HTLV-I infection_Homo sapiens_hsa051660.34212941
136Choline metabolism in cancer_Homo sapiens_hsa052310.33709854
137Viral carcinogenesis_Homo sapiens_hsa052030.33603201
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32505757
139Vitamin B6 metabolism_Homo sapiens_hsa007500.31151912
140Insulin resistance_Homo sapiens_hsa049310.31009356
141Endometrial cancer_Homo sapiens_hsa052130.29047105
142mTOR signaling pathway_Homo sapiens_hsa041500.28487129
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28482928
144Estrogen signaling pathway_Homo sapiens_hsa049150.27015774
145Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26450839
146Hepatitis C_Homo sapiens_hsa051600.23853244
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23320803
148ErbB signaling pathway_Homo sapiens_hsa040120.22816078
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22488240
150Measles_Homo sapiens_hsa051620.22241750
151Shigellosis_Homo sapiens_hsa051310.20985827
152Antigen processing and presentation_Homo sapiens_hsa046120.20286428
153African trypanosomiasis_Homo sapiens_hsa051430.20082921
154Leukocyte transendothelial migration_Homo sapiens_hsa046700.19897077
155Fatty acid biosynthesis_Homo sapiens_hsa000610.18891632
156TNF signaling pathway_Homo sapiens_hsa046680.17347248
157Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17138903
158Amoebiasis_Homo sapiens_hsa051460.16506615
159Influenza A_Homo sapiens_hsa051640.16420192
160Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16178063
161Salmonella infection_Homo sapiens_hsa051320.16045390
162Toxoplasmosis_Homo sapiens_hsa051450.15041838
163Metabolic pathways_Homo sapiens_hsa011000.13116177

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