CD300LB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)7.73506016
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.73506016
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.73506016
4positive regulation by organism of defense response of other organism involved in symbiotic interact7.73506016
5modulation by symbiont of host immune response (GO:0052553)7.73506016
6positive regulation by symbiont of host defense response (GO:0052509)7.73506016
7regulation of interferon-beta biosynthetic process (GO:0045357)6.90272494
8neutrophil activation involved in immune response (GO:0002283)6.74295548
9positive regulation of interleukin-8 biosynthetic process (GO:0045416)6.38782771
10regulation of B cell receptor signaling pathway (GO:0050855)5.75827958
11respiratory burst (GO:0045730)5.58055895
12response to host immune response (GO:0052572)5.46582000
13response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.46582000
14macrophage activation involved in immune response (GO:0002281)5.36751290
15detection of bacterium (GO:0016045)5.05228550
16response to peptidoglycan (GO:0032494)5.01175470
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.99795670
18response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.99725024
19response to host (GO:0075136)4.99725024
20response to host defenses (GO:0052200)4.99725024
21cellular extravasation (GO:0045123)4.96062836
22negative regulation of interleukin-12 production (GO:0032695)4.95341922
23immunoglobulin mediated immune response (GO:0016064)4.93132173
24antigen processing and presentation of endogenous antigen (GO:0019883)4.92194002
25detection of external biotic stimulus (GO:0098581)4.70067583
26positive regulation of interferon-alpha production (GO:0032727)4.65919380
27leukocyte migration involved in inflammatory response (GO:0002523)4.65034616
28neutrophil activation (GO:0042119)4.64590561
29production of molecular mediator involved in inflammatory response (GO:0002532)4.57250445
30granulocyte activation (GO:0036230)4.45646248
31regulation of interferon-alpha production (GO:0032647)4.40101191
32myeloid cell activation involved in immune response (GO:0002275)4.35173212
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.32615693
34regulation of interleukin-8 biosynthetic process (GO:0045414)4.29730511
35detection of biotic stimulus (GO:0009595)4.27583480
36regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.22329730
37negative regulation of mast cell activation (GO:0033004)4.21159240
38regulation of gamma-delta T cell activation (GO:0046643)4.19138446
39regulation of mast cell degranulation (GO:0043304)4.13211792
40microglial cell activation (GO:0001774)4.13029100
41regulation of leukocyte degranulation (GO:0043300)4.08676004
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.96639782
43positive regulation of antigen processing and presentation (GO:0002579)3.95760973
44leukocyte aggregation (GO:0070486)3.95393357
45Arp2/3 complex-mediated actin nucleation (GO:0034314)3.91046939
46negative regulation of phagocytosis (GO:0050765)3.89578054
47* neutrophil mediated immunity (GO:0002446)3.88352330
48regulation of mast cell activation involved in immune response (GO:0033006)3.87322044
49pinocytosis (GO:0006907)3.85957455
50regulation of myeloid leukocyte mediated immunity (GO:0002886)3.84005080
51response to fungus (GO:0009620)3.83662321
52macrophage activation (GO:0042116)3.74497249
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69259529
54negative regulation of cell killing (GO:0031342)3.69259529
55* regulation of mast cell activation (GO:0033003)3.66692694
56neutrophil chemotaxis (GO:0030593)3.65441781
57negative regulation of leukocyte mediated immunity (GO:0002704)3.57422136
58negative regulation of T cell mediated immunity (GO:0002710)3.55549971
59positive regulation of mast cell degranulation (GO:0043306)3.55162501
60positive regulation of mast cell activation involved in immune response (GO:0033008)3.55162501
61neutrophil migration (GO:1990266)3.55091312
62B cell mediated immunity (GO:0019724)3.53064410
63defense response to fungus (GO:0050832)3.49509877
64mannose metabolic process (GO:0006013)3.47714225
65regulation of gamma-delta T cell differentiation (GO:0045586)3.42457796
66antigen processing and presentation via MHC class Ib (GO:0002475)3.41708451
67negative regulation of erythrocyte differentiation (GO:0045647)3.39168997
68macrophage differentiation (GO:0030225)3.38898898
69regulation of T cell tolerance induction (GO:0002664)3.38809935
70positive regulation of leukocyte degranulation (GO:0043302)3.38387969
71regulation of tolerance induction (GO:0002643)3.36814461
72regulation of regulated secretory pathway (GO:1903305)3.34725490
73positive regulation of cellular amide metabolic process (GO:0034250)3.32940253
74leukocyte mediated cytotoxicity (GO:0001909)3.32504989
75lipopolysaccharide-mediated signaling pathway (GO:0031663)3.30054893
76leukocyte degranulation (GO:0043299)3.28972676
77regulation of antigen processing and presentation (GO:0002577)3.28444891
78phagosome maturation (GO:0090382)3.27576984
79positive regulation of B cell differentiation (GO:0045579)3.23605235
80reactive oxygen species biosynthetic process (GO:1903409)3.22835894
81regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.21526632
82response to interleukin-15 (GO:0070672)3.21158457
83positive regulation of interferon-beta production (GO:0032728)3.21101344
84positive regulation of gamma-delta T cell activation (GO:0046645)3.20794321
85leukotriene metabolic process (GO:0006691)3.17695570
86regulation of T-helper 2 cell differentiation (GO:0045628)3.16155334
87interferon-gamma-mediated signaling pathway (GO:0060333)3.15596775
88disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.14031543
89killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.14031543
90* positive regulation of mast cell activation (GO:0033005)3.10734475
91negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.10257476
92granulocyte chemotaxis (GO:0071621)3.09267292
93actin nucleation (GO:0045010)3.08618264
94negative regulation of interleukin-17 production (GO:0032700)3.08612542
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07255452
96myeloid leukocyte activation (GO:0002274)3.04590600
97germinal center formation (GO:0002467)3.02547242
98regulation of dendritic cell antigen processing and presentation (GO:0002604)3.01469705
99positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.01235698
100type I interferon signaling pathway (GO:0060337)3.00678499
101cellular response to type I interferon (GO:0071357)3.00678499
102B cell receptor signaling pathway (GO:0050853)3.00388265
103positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.99595175
104regulation of B cell differentiation (GO:0045577)2.99572338
105granulocyte migration (GO:0097530)2.99314634
106superoxide anion generation (GO:0042554)2.98510438
107response to type I interferon (GO:0034340)2.97652576
108antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.95768178
109antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.95768178
110regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.95558617
111negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.95293668
112negative regulation of interleukin-1 production (GO:0032692)2.94285136
113regulation of cholesterol storage (GO:0010885)2.93570110
114hydrogen peroxide biosynthetic process (GO:0050665)2.92513840
115regulation of phagocytosis (GO:0050764)2.90110893
116detection of molecule of bacterial origin (GO:0032490)2.89849105
117positive thymic T cell selection (GO:0045059)2.88656277
118negative regulation of cytokine production involved in immune response (GO:0002719)2.87878846
119hyaluronan catabolic process (GO:0030214)2.86257073
120regulation of macrophage cytokine production (GO:0010935)2.85741986
121T-helper 1 type immune response (GO:0042088)2.85734053
122dendritic cell migration (GO:0036336)2.85104907
123I-kappaB phosphorylation (GO:0007252)2.84118644
124positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.83841192
125cellular response to interleukin-15 (GO:0071350)2.83762311
126negative regulation of type 2 immune response (GO:0002829)2.83214481
127response to muramyl dipeptide (GO:0032495)2.83202310
128detection of other organism (GO:0098543)2.82349540
129positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.81984186
130negative regulation of interleukin-1 beta production (GO:0032691)2.81597852
131negative regulation of interleukin-6 production (GO:0032715)2.80661058
132positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.78170678
133defense response to protozoan (GO:0042832)2.78161075
134low-density lipoprotein particle clearance (GO:0034383)2.77356883
135lymphocyte chemotaxis (GO:0048247)2.76471288
136* myeloid leukocyte mediated immunity (GO:0002444)2.75612578
137natural killer cell mediated cytotoxicity (GO:0042267)2.74664734
138natural killer cell mediated immunity (GO:0002228)2.74664734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.42571141
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.53597682
3* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.44052977
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.43517524
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.43107327
6MYB_21317192_ChIP-Seq_ERMYB_Mouse4.09263543
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.03179457
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.95788875
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.75641377
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.14519592
11* BRD4_27068464_Chip-Seq_AML-cells_Mouse3.02995379
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.70530001
13* SPI1_23547873_ChIP-Seq_NB4_Human2.67852672
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66743226
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.66559791
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50680722
17VDR_21846776_ChIP-Seq_THP-1_Human2.48486197
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45780178
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44305811
20RUNX1_22412390_ChIP-Seq_EML_Mouse2.25449795
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21209238
22SPI1_23127762_ChIP-Seq_K562_Human2.19882636
23VDR_24763502_ChIP-Seq_THP-1_Human2.19171659
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.11615139
25SCL_19346495_ChIP-Seq_HPC-7_Human2.07276186
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04699028
27E2F7_22180533_ChIP-Seq_HELA_Human1.99826156
28PU_27001747_Chip-Seq_BMDM_Mouse1.99052274
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94572630
30* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91931161
31* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.89036572
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82799315
33MYB_26560356_Chip-Seq_TH2_Human1.80601023
34* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.79991758
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73679871
36MAF_26560356_Chip-Seq_TH1_Human1.72587122
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70993774
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69757246
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64767130
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63596042
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.57964752
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57041130
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56024707
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55795253
45VDR_24787735_ChIP-Seq_THP-1_Human1.52938564
46* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.50546988
47UTX_26944678_Chip-Seq_JUKART_Human1.48974476
48MYB_26560356_Chip-Seq_TH1_Human1.46164291
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46066528
50CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45788821
51PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44022635
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.43693373
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39786509
54TCF7_22412390_ChIP-Seq_EML_Mouse1.38328933
55RUNX_20019798_ChIP-Seq_JUKART_Human1.37759269
56TFEB_21752829_ChIP-Seq_HELA_Human1.37687243
57MYC_22102868_ChIP-Seq_BL_Human1.37528733
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34187006
59* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34095077
60* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31890703
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30636096
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28279669
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24731639
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23767071
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21980291
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.21337460
67GATA3_27048872_Chip-Seq_THYMUS_Human1.20001522
68GATA3_26560356_Chip-Seq_TH2_Human1.19535963
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19264521
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.19174369
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16340003
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11800096
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11675672
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11537141
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.09289227
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06578040
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.06244878
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06151337
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05511958
80LXR_22292898_ChIP-Seq_THP-1_Human1.04014801
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02648853
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01756558
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01564571
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01166426
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01036579
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97865961
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97643441
88SPI1_20517297_ChIP-Seq_HL60_Human0.97242510
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97122830
90KDM2B_26808549_Chip-Seq_DND41_Human0.95577556
91MAF_26560356_Chip-Seq_TH2_Human0.95531861
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93433410
93GATA1_22025678_ChIP-Seq_K562_Human0.91705309
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90329732
95GATA1_19941826_ChIP-Seq_K562_Human0.90303438
96GATA2_19941826_ChIP-Seq_K562_Human0.89721993
97BCOR_27268052_Chip-Seq_Bcells_Human0.88411738
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84275981
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80270083
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79782332
101* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79686719
102PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74501598
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74447881
104EGR1_19032775_ChIP-ChIP_M12_Human0.73420433
105BCL6_27268052_Chip-Seq_Bcells_Human0.71390795
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69622583
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.68959291
108RARG_19884340_ChIP-ChIP_MEFs_Mouse0.68538146
109EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.68452535
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.68079095
111NCOR1_26117541_ChIP-Seq_K562_Human0.67010974

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.69727010
2MP0003436_decreased_susceptibility_to4.38204967
3MP0003303_peritoneal_inflammation3.94408791
4MP0001835_abnormal_antigen_presentation3.50522418
5MP0003172_abnormal_lysosome_physiology3.40960861
6MP0002419_abnormal_innate_immunity3.40213619
7MP0009785_altered_susceptibility_to2.77351984
8MP0005000_abnormal_immune_tolerance2.69911682
9MP0006082_CNS_inflammation2.60223672
10MP0005025_abnormal_response_to2.53825947
11MP0009278_abnormal_bone_marrow2.51357985
12MP0002148_abnormal_hypersensitivity_rea2.46741255
13MP0002452_abnormal_antigen_presenting2.37481934
14MP0001533_abnormal_skeleton_physiology2.28065299
15MP0000343_altered_response_to2.23943044
16MP0009840_abnormal_foam_cell2.20611043
17MP0003724_increased_susceptibility_to2.18233528
18MP0003191_abnormal_cellular_cholesterol2.16806307
19MP0005464_abnormal_platelet_physiology2.14692364
20MP0001800_abnormal_humoral_immune2.12015157
21MP0003183_abnormal_peptide_metabolism2.11311536
22MP0001790_abnormal_immune_system2.10663865
23MP0005387_immune_system_phenotype2.10663865
24MP0000569_abnormal_digit_pigmentation2.06283416
25MP0001819_abnormal_immune_cell2.04537563
26MP0002420_abnormal_adaptive_immunity2.04423717
27MP0002723_abnormal_immune_serum2.03896513
28MP0003690_abnormal_glial_cell2.03294147
29MP0000604_amyloidosis1.97401290
30MP0003300_gastrointestinal_ulcer1.92628937
31MP0002405_respiratory_system_inflammati1.90670716
32MP0003075_altered_response_to1.88230857
33MP0000685_abnormal_immune_system1.85357802
34MP0003448_altered_tumor_morphology1.77704929
35MP0001853_heart_inflammation1.75002958
36MP0001845_abnormal_inflammatory_respons1.74735674
37MP0002132_abnormal_respiratory_system1.73234651
38MP0005397_hematopoietic_system_phenotyp1.71713650
39MP0001545_abnormal_hematopoietic_system1.71713650
40MP0000465_gastrointestinal_hemorrhage1.70652672
41MP0003763_abnormal_thymus_physiology1.67959823
42MP0000858_altered_metastatic_potential1.64396822
43MP0005451_abnormal_body_composition1.60735386
44MP0005671_abnormal_response_to1.58747571
45MP0005167_abnormal_blood-brain_barrier1.54872060
46MP0005174_abnormal_tail_pigmentation1.52766333
47MP0004510_myositis1.50136056
48MP0000716_abnormal_immune_system1.48840806
49MP0008469_abnormal_protein_level1.47974430
50MP0010307_abnormal_tumor_latency1.46499180
51MP0000689_abnormal_spleen_morphology1.46186395
52MP0002933_joint_inflammation1.44390383
53MP0003656_abnormal_erythrocyte_physiolo1.44059611
54MP0002166_altered_tumor_susceptibility1.38013126
55MP0002398_abnormal_bone_marrow1.36321070
56MP0001851_eye_inflammation1.35659469
57MP0009764_decreased_sensitivity_to1.35561247
58MP0004947_skin_inflammation1.34400980
59MP0003566_abnormal_cell_adhesion1.33825124
60MP0002396_abnormal_hematopoietic_system1.33018341
61MP0003866_abnormal_defecation1.31288629
62MP0005310_abnormal_salivary_gland1.30461391
63MP0009333_abnormal_splenocyte_physiolog1.27382991
64MP0002429_abnormal_blood_cell1.25495267
65MP0002722_abnormal_immune_system1.21844833
66MP0010155_abnormal_intestine_physiology1.20002708
67MP0003828_pulmonary_edema1.19918007
68MP0002998_abnormal_bone_remodeling1.13821858
69MP0004808_abnormal_hematopoietic_stem1.12692394
70MP0004883_abnormal_blood_vessel1.11215575
71MP0004381_abnormal_hair_follicle1.11171892
72MP0005257_abnormal_intraocular_pressure1.10988477
73MP0005164_abnormal_response_to1.07320777
74MP0005390_skeleton_phenotype1.07225810
75* MP0005166_decreased_susceptibility_to1.05100412
76MP0003806_abnormal_nucleotide_metabolis1.03313383
77MP0001958_emphysema1.02825995
78MP0002006_tumorigenesis0.96216105
79MP0003279_aneurysm0.95800893
80MP0008004_abnormal_stomach_pH0.95458168
81MP0000920_abnormal_myelination0.94376569
82MP0000015_abnormal_ear_pigmentation0.93330082
83MP0009763_increased_sensitivity_to0.91506096
84MP0002277_abnormal_respiratory_mucosa0.90995011
85MP0008438_abnormal_cutaneous_collagen0.90057900
86MP0003705_abnormal_hypodermis_morpholog0.89868497
87MP0000490_abnormal_crypts_of0.88612086
88MP0005076_abnormal_cell_differentiation0.86804476
89MP0000249_abnormal_blood_vessel0.83135827
90MP0001873_stomach_inflammation0.81871171
91MP0008260_abnormal_autophagy0.81031381
92MP0003795_abnormal_bone_structure0.79440010
93MP0005023_abnormal_wound_healing0.76791592
94MP0003329_amyloid_beta_deposits0.73423910
95MP0001663_abnormal_digestive_system0.72597592
96MP0005075_abnormal_melanosome_morpholog0.64385259
97MP0001986_abnormal_taste_sensitivity0.63959667
98MP0009765_abnormal_xenobiotic_induced0.62865151
99MP0008874_decreased_physiological_sensi0.61591832
100MP0000609_abnormal_liver_physiology0.61002989
101MP0000371_diluted_coat_color0.60758427
102MP0003186_abnormal_redox_activity0.59708306
103MP0002009_preneoplasia0.59391923
104MP0003045_fibrosis0.59067314
105MP0004130_abnormal_muscle_cell0.58512112
106MP0000767_abnormal_smooth_muscle0.58492864
107MP0002837_dystrophic_cardiac_calcinosis0.58343843
108MP0005083_abnormal_biliary_tract0.57491371
109MP0000703_abnormal_thymus_morphology0.57370267
110MP0002090_abnormal_vision0.57205588
111MP0003091_abnormal_cell_migration0.57164429
112MP0002332_abnormal_exercise_endurance0.56261667
113MP0003221_abnormal_cardiomyocyte_apopto0.55874505
114MP0003634_abnormal_glial_cell0.55598953
115MP0000598_abnormal_liver_morphology0.55330709
116MP0005319_abnormal_enzyme/_coenzyme0.54780203
117MP0006054_spinal_hemorrhage0.53649474
118MP0005388_respiratory_system_phenotype0.53069194
119MP0002133_abnormal_respiratory_system0.53069194
120MP0010329_abnormal_lipoprotein_level0.52575601

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.43009054
2Vacuolated lymphocytes (HP:0001922)6.61432541
3Increased cerebral lipofuscin (HP:0011813)6.53368426
4Recurrent bacterial skin infections (HP:0005406)6.22101879
5Eczematoid dermatitis (HP:0000976)6.17978140
6Recurrent gram-negative bacterial infections (HP:0005420)6.10326288
7Abnormality of macrophages (HP:0004311)5.46740386
8Increased neuronal autofluorescent lipopigment (HP:0002074)5.42870008
9Dysostosis multiplex (HP:0000943)5.11689920
10Systemic lupus erythematosus (HP:0002725)4.56896712
11Abnormality of liposaccharide metabolism (HP:0010968)4.52205856
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.52205856
13Abnormality of glycolipid metabolism (HP:0010969)4.52205856
14Urinary glycosaminoglycan excretion (HP:0003541)4.35185921
15Mucopolysacchariduria (HP:0008155)4.35185921
16Chronic obstructive pulmonary disease (HP:0006510)4.21573346
17Obstructive lung disease (HP:0006536)4.21573346
18Abnormality of mucopolysaccharide metabolism (HP:0011020)4.09189583
19Abnormality of polysaccharide metabolism (HP:0011012)4.09189583
20Abnormality of glycosaminoglycan metabolism (HP:0004371)4.09189583
21Disinhibition (HP:0000734)4.09036280
22Axonal loss (HP:0003447)3.94346501
23Myositis (HP:0100614)3.86011245
24Gingivitis (HP:0000230)3.84747098
25Loss of speech (HP:0002371)3.80718013
26Gastrointestinal infarctions (HP:0005244)3.77214901
27Spontaneous hematomas (HP:0007420)3.76823521
28Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.74357134
29Mediastinal lymphadenopathy (HP:0100721)3.65165306
30Recurrent skin infections (HP:0001581)3.63194482
31Keratoconjunctivitis sicca (HP:0001097)3.60914474
32Agnosia (HP:0010524)3.47196082
33Amyloidosis (HP:0011034)3.44227781
34Encephalitis (HP:0002383)3.37960917
35Keratoconjunctivitis (HP:0001096)3.32091138
36Abnormal delayed hypersensitivity skin test (HP:0002963)3.25379537
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.20634244
38Hepatosplenomegaly (HP:0001433)3.19343824
39Orchitis (HP:0100796)3.13074708
40Glomerulonephritis (HP:0000099)3.11633056
41Thoracic kyphosis (HP:0002942)3.11319339
42J-shaped sella turcica (HP:0002680)3.07334045
43Increased IgE level (HP:0003212)3.00749824
44Recurrent fungal infections (HP:0002841)3.00114341
45Episodic fever (HP:0001954)2.99614562
46Chest pain (HP:0100749)2.99059761
47Hypochromic microcytic anemia (HP:0004840)2.89553900
48Abnormality of the lumbar spine (HP:0100712)2.88342596
49Urticaria (HP:0001025)2.87982906
50Upper motor neuron abnormality (HP:0002127)2.87742154
51T lymphocytopenia (HP:0005403)2.84848591
52Cellulitis (HP:0100658)2.81039210
53Periodontitis (HP:0000704)2.77890371
54Elevated erythrocyte sedimentation rate (HP:0003565)2.71188859
55Stomatitis (HP:0010280)2.70330184
56Abnormality of T cell number (HP:0011839)2.66639440
57Joint hemorrhage (HP:0005261)2.66498516
58Asymmetric septal hypertrophy (HP:0001670)2.57911789
59Autoimmune thrombocytopenia (HP:0001973)2.55158543
60Hypochromic anemia (HP:0001931)2.54876835
61Pustule (HP:0200039)2.54587941
62Anorexia (HP:0002039)2.53883408
63Abnormality of the vasculature of the conjunctiva (HP:0008054)2.53677520
64Pulmonary embolism (HP:0002204)2.52650046
65Optic neuritis (HP:0100653)2.50189640
66Retrobulbar optic neuritis (HP:0100654)2.50189640
67Myocardial infarction (HP:0001658)2.45895615
68Purpura (HP:0000979)2.44093697
69Peritonitis (HP:0002586)2.44070449
70Meningitis (HP:0001287)2.40699277
71Hematochezia (HP:0002573)2.39654438
72Abnormality of the thoracic spine (HP:0100711)2.39341001
73Osteomyelitis (HP:0002754)2.37006935
74Diminished motivation (HP:0000745)2.36200350
75Pathologic fracture (HP:0002756)2.32252172
76Gangrene (HP:0100758)2.30913571
77Abnormality of complement system (HP:0005339)2.26895833
78Increased serum ferritin (HP:0003281)2.26580582
79Apathy (HP:0000741)2.26471485
80Abnormality of T cells (HP:0002843)2.23029707
81Abnormality of the pleura (HP:0002103)2.22058750
82Neuronal loss in central nervous system (HP:0002529)2.20917536
83Basal ganglia calcification (HP:0002135)2.20304795
84Polyneuropathy (HP:0001271)2.18680305
85Increased IgM level (HP:0003496)2.17432495
86Conjunctival telangiectasia (HP:0000524)2.16919348
87Global brain atrophy (HP:0002283)2.13020429
88Peripheral demyelination (HP:0011096)2.12597914
89Colitis (HP:0002583)2.11076033
90Recurrent viral infections (HP:0004429)2.10413560
91Recurrent pneumonia (HP:0006532)2.10070758
92Vertigo (HP:0002321)2.09297218
93Petechiae (HP:0000967)2.07744528
94Personality changes (HP:0000751)2.07414026
95Panhypogammaglobulinemia (HP:0003139)2.07186530
96Glomerulopathy (HP:0100820)2.07180197
97Abnormality of the endocardium (HP:0004306)2.06444527
98Interstitial pulmonary disease (HP:0006530)2.05777103
99Granulocytopenia (HP:0001913)2.05736812
100Vasculitis (HP:0002633)2.05601045
101Inappropriate behavior (HP:0000719)2.05362587
102Abnormality of the peritoneum (HP:0002585)2.04985369
103Spondylolisthesis (HP:0003302)2.04896870
104Prostate neoplasm (HP:0100787)2.04464910
105Abnormality of iron homeostasis (HP:0011031)2.04438630
106Leukocytosis (HP:0001974)2.03056736
107Microcytic anemia (HP:0001935)2.02706575
108Epistaxis (HP:0000421)2.02535987
109Nephritis (HP:0000123)2.00075465
110Deformed sella turcica (HP:0002681)1.97512910
111Amaurosis fugax (HP:0100576)1.96757586
112Inflammation of the large intestine (HP:0002037)1.96643092
113Ovoid vertebral bodies (HP:0003300)1.96130022
114Complement deficiency (HP:0004431)1.94383201
115Slow saccadic eye movements (HP:0000514)1.93613915
116Chronic mucocutaneous candidiasis (HP:0002728)1.93306601
117Recurrent cutaneous fungal infections (HP:0011370)1.93306601
118Hypergammaglobulinemia (HP:0010702)1.93161221
119Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93051387
120Premature loss of primary teeth (HP:0006323)1.91010731
121Increased CSF protein (HP:0002922)1.90552146
122Lymphopenia (HP:0001888)1.90302012
123Progressive neurologic deterioration (HP:0002344)1.89907403
124Abnormal platelet volume (HP:0011876)1.89774665
125Acne (HP:0001061)1.89503321
126Gingival bleeding (HP:0000225)1.89106113
127Skin ulcer (HP:0200042)1.87921537
128Chronic otitis media (HP:0000389)1.86072283
129Gastrointestinal inflammation (HP:0004386)1.84653592
130Prolonged bleeding time (HP:0003010)1.84210366
131Pulmonary infiltrates (HP:0002113)1.83964654
132Arterial thrombosis (HP:0004420)1.82324605
133Poor head control (HP:0002421)1.80359785
134Thickened calvaria (HP:0002684)1.79926175
135Neurodegeneration (HP:0002180)1.79178031
136Hemoptysis (HP:0002105)1.78759565
137Mucosal telangiectasiae (HP:0100579)1.74540633
138Sepsis (HP:0100806)1.74527447
139Abnormal platelet function (HP:0011869)1.74446477
140Impaired platelet aggregation (HP:0003540)1.74446477
141Hypercholesterolemia (HP:0003124)1.74105265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.84154036
2RIPK43.58598993
3IRAK43.44468894
4KIT3.29959248
5ERN13.19508069
6MAP2K32.56860276
7TEC2.49033997
8PRPF4B2.48982490
9TYK22.42591089
10BTK2.31143003
11FES2.30962013
12TAOK32.29569977
13TBK12.25647958
14TRIB32.19051501
15MAP4K12.15721543
16TNK22.10769267
17TGFBR21.92692040
18EPHB11.92483772
19HCK1.91129549
20CSK1.89837164
21CSF1R1.86408489
22STK101.85524930
23PKN21.84444844
24ITK1.74690915
25TRPM71.72530601
26ZAP701.69269947
27MAP3K31.60912236
28FGR1.57531893
29IRAK31.56776339
30SYK1.51405718
31GRK61.46915548
32TTN1.36553134
33CAMK1D1.32611489
34MAP3K141.32543409
35LRRK21.31389610
36RIPK11.27858048
37TESK21.27771228
38BMPR21.27232390
39SCYL21.24457524
40NME21.23980206
41LYN1.22671377
42CAMKK21.21465783
43CLK11.20010290
44SIK31.17309293
45PAK41.16887756
46JAK11.15524182
47JAK21.14303794
48MAP3K111.11701946
49NEK91.10666414
50IRAK21.04362240
51LCK1.04128861
52PTK61.02739455
53ERBB31.00133876
54IKBKB0.98351017
55IRAK10.94390931
56MARK20.94171207
57MATK0.92356585
58IKBKE0.92064724
59PIM20.90167192
60RPS6KA40.84229776
61CAMKK10.78973972
62ABL20.78281387
63CAMK1G0.77136514
64CDK190.76910264
65JAK30.76553947
66MARK30.76131167
67GRK70.75555948
68MAPK120.74301343
69MAP3K20.73303498
70PRKD20.73179332
71PIM10.71805184
72EGFR0.71139094
73PRKCD0.70966187
74MAPK70.70254756
75FLT30.70009840
76MAP3K130.68435021
77CDK120.68263791
78ABL10.65313194
79SIK20.64939941
80MOS0.62289733
81CDC42BPA0.61634776
82TESK10.61022387
83SGK30.60825062
84TXK0.60214544
85STK40.58237653
86MAP2K40.54363609
87MAP3K70.52892388
88KSR20.51370059
89CDK60.50622054
90STK110.50465716
91MAP3K80.49522930
92DAPK20.49248582
93DYRK1B0.48852904
94KSR10.47822241
95RPS6KA60.47250962
96PRKCQ0.47148548
97SMG10.46319001
98MAPKAPK20.46091494
99MAP3K10.45837548
100MAP3K60.45437038
101PRKG20.45237865
102KDR0.43639090
103PTK2B0.43071308
104RPS6KC10.42325963
105RPS6KL10.42325963
106FGFR30.41799444
107PIK3CG0.41742972
108* FYN0.41671443
109TAOK20.41593277
110RAF10.40935498
111PTK20.40916972
112SGK20.39698848
113PDK10.39455385
114PDPK10.38579156
115YES10.38561211
116RPS6KA20.37522579
117TAOK10.35275389
118HIPK20.35121506
119IGF1R0.34747647
120PRKCH0.34270219
121RET0.33353335
122MAP3K50.32793249
123MAP3K120.32739200
124EPHA30.29593946
125CAMK40.29564112
126MAP2K60.29099862
127CDK90.28438106
128ALK0.26720141
129MAPK40.24745556
130SRC0.24144758
131NEK20.24061013

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.54047728
2Staphylococcus aureus infection_Homo sapiens_hsa051504.28411990
3Lysosome_Homo sapiens_hsa041423.81980654
4Other glycan degradation_Homo sapiens_hsa005113.64616803
5Leishmaniasis_Homo sapiens_hsa051403.35472578
6Osteoclast differentiation_Homo sapiens_hsa043802.60265858
7Phagosome_Homo sapiens_hsa041452.52353033
8Graft-versus-host disease_Homo sapiens_hsa053322.50584013
9Tuberculosis_Homo sapiens_hsa051522.36844236
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.28053339
11Autoimmune thyroid disease_Homo sapiens_hsa053202.26903969
12Pertussis_Homo sapiens_hsa051332.22626916
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18496313
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.01528125
15Caffeine metabolism_Homo sapiens_hsa002321.94704914
16Type I diabetes mellitus_Homo sapiens_hsa049401.87234610
17B cell receptor signaling pathway_Homo sapiens_hsa046621.85377804
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83827658
19Malaria_Homo sapiens_hsa051441.73150879
20Legionellosis_Homo sapiens_hsa051341.72741448
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.62858174
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56707422
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.51199180
24Complement and coagulation cascades_Homo sapiens_hsa046101.47536723
25Shigellosis_Homo sapiens_hsa051311.45136258
26Salmonella infection_Homo sapiens_hsa051321.42059649
27Rheumatoid arthritis_Homo sapiens_hsa053231.41349497
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39664509
29Antigen processing and presentation_Homo sapiens_hsa046121.38364397
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.38045353
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33825539
32Toxoplasmosis_Homo sapiens_hsa051451.30541397
33Measles_Homo sapiens_hsa051621.30024086
34Apoptosis_Homo sapiens_hsa042101.26546832
35Hematopoietic cell lineage_Homo sapiens_hsa046401.20683497
36Chemokine signaling pathway_Homo sapiens_hsa040621.20031940
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20018406
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15889727
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11609180
40African trypanosomiasis_Homo sapiens_hsa051431.10643816
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07850237
42Influenza A_Homo sapiens_hsa051641.03850090
43Sphingolipid metabolism_Homo sapiens_hsa006001.03830902
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01266191
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.01256820
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01061054
47Hepatitis B_Homo sapiens_hsa051611.00347571
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94495100
49Collecting duct acid secretion_Homo sapiens_hsa049660.93591893
50Asthma_Homo sapiens_hsa053100.90254757
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.87660104
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86959952
53Pancreatic cancer_Homo sapiens_hsa052120.86938488
54TNF signaling pathway_Homo sapiens_hsa046680.85839203
55Pentose phosphate pathway_Homo sapiens_hsa000300.85563800
56Chronic myeloid leukemia_Homo sapiens_hsa052200.85377048
57Acute myeloid leukemia_Homo sapiens_hsa052210.82651418
58Amoebiasis_Homo sapiens_hsa051460.81677768
59Platelet activation_Homo sapiens_hsa046110.81545301
60Viral myocarditis_Homo sapiens_hsa054160.77828261
61Endocytosis_Homo sapiens_hsa041440.76403593
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.75247326
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.73353796
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73160041
65Herpes simplex infection_Homo sapiens_hsa051680.72709894
66Renin-angiotensin system_Homo sapiens_hsa046140.71505470
67Hepatitis C_Homo sapiens_hsa051600.66548612
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64242553
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.63476716
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63393838
71Notch signaling pathway_Homo sapiens_hsa043300.61481520
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60903294
73GnRH signaling pathway_Homo sapiens_hsa049120.59434120
74VEGF signaling pathway_Homo sapiens_hsa043700.59336710
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57812119
76Galactose metabolism_Homo sapiens_hsa000520.57178671
77Starch and sucrose metabolism_Homo sapiens_hsa005000.54706285
78FoxO signaling pathway_Homo sapiens_hsa040680.54398593
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52580037
80Non-small cell lung cancer_Homo sapiens_hsa052230.51664926
81Endometrial cancer_Homo sapiens_hsa052130.51385194
82Histidine metabolism_Homo sapiens_hsa003400.51210762
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50363215
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50268451
85Proteoglycans in cancer_Homo sapiens_hsa052050.49697787
86Choline metabolism in cancer_Homo sapiens_hsa052310.48814928
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48627752
88HIF-1 signaling pathway_Homo sapiens_hsa040660.48416851
89T cell receptor signaling pathway_Homo sapiens_hsa046600.48007084
90Type II diabetes mellitus_Homo sapiens_hsa049300.47849059
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47586843
92Dorso-ventral axis formation_Homo sapiens_hsa043200.47436329
93HTLV-I infection_Homo sapiens_hsa051660.46062223
94mTOR signaling pathway_Homo sapiens_hsa041500.45713855
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44577335
96MAPK signaling pathway_Homo sapiens_hsa040100.39844749
97Inositol phosphate metabolism_Homo sapiens_hsa005620.39235423
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38195823
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37986330
100Regulation of autophagy_Homo sapiens_hsa041400.37189025
101Vibrio cholerae infection_Homo sapiens_hsa051100.37104995
102Steroid biosynthesis_Homo sapiens_hsa001000.36333919
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36325987
104Rap1 signaling pathway_Homo sapiens_hsa040150.35967660
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35639700
106Bladder cancer_Homo sapiens_hsa052190.34761555
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34074790
108Viral carcinogenesis_Homo sapiens_hsa052030.32944229
109Insulin resistance_Homo sapiens_hsa049310.31874545
110N-Glycan biosynthesis_Homo sapiens_hsa005100.30550996
111Primary immunodeficiency_Homo sapiens_hsa053400.29368412
112Epstein-Barr virus infection_Homo sapiens_hsa051690.28946645
113Allograft rejection_Homo sapiens_hsa053300.27623042
114Colorectal cancer_Homo sapiens_hsa052100.24781913
115Renal cell carcinoma_Homo sapiens_hsa052110.23879120
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.22735002
117Prolactin signaling pathway_Homo sapiens_hsa049170.21370962
118Glioma_Homo sapiens_hsa052140.19526241
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.18938233
120Fructose and mannose metabolism_Homo sapiens_hsa000510.18794692
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18748447
122Mineral absorption_Homo sapiens_hsa049780.18120740
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.17249696
124Focal adhesion_Homo sapiens_hsa045100.16770396

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