CD300LD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)7.10793819
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.10793819
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.10793819
4positive regulation by organism of defense response of other organism involved in symbiotic interact7.10793819
5modulation by symbiont of host immune response (GO:0052553)7.10793819
6positive regulation by symbiont of host defense response (GO:0052509)7.10793819
7neutrophil activation involved in immune response (GO:0002283)6.16449655
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.02576547
9regulation of interferon-beta biosynthetic process (GO:0045357)5.90334352
10positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.15922589
11macrophage activation involved in immune response (GO:0002281)4.98905298
12DNA deamination (GO:0045006)4.93138536
13regulation of B cell receptor signaling pathway (GO:0050855)4.77813123
14response to peptidoglycan (GO:0032494)4.74515885
15immunoglobulin mediated immune response (GO:0016064)4.73648269
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.71537122
17response to host immune response (GO:0052572)4.71537122
18production of molecular mediator involved in inflammatory response (GO:0002532)4.68732988
19positive regulation of interferon-alpha production (GO:0032727)4.58483769
20respiratory burst (GO:0045730)4.51108275
21microglial cell activation (GO:0001774)4.47356997
22piRNA metabolic process (GO:0034587)4.43350730
23regulation of interferon-alpha production (GO:0032647)4.35078005
24positive regulation of antigen processing and presentation (GO:0002579)4.31783005
25behavioral response to nicotine (GO:0035095)4.27550626
26cellular extravasation (GO:0045123)4.23433696
27response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.21969022
28response to host (GO:0075136)4.21969022
29response to host defenses (GO:0052200)4.21969022
30positive regulation of mast cell activation (GO:0033005)4.10173535
31positive regulation of cellular amide metabolic process (GO:0034250)4.08575396
32regulation of cholesterol storage (GO:0010885)4.06500892
33fucose catabolic process (GO:0019317)4.05755187
34L-fucose metabolic process (GO:0042354)4.05755187
35L-fucose catabolic process (GO:0042355)4.05755187
36neutrophil activation (GO:0042119)4.04642324
37pinocytosis (GO:0006907)3.97779859
38macrophage activation (GO:0042116)3.96045157
39granulocyte activation (GO:0036230)3.90920564
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.86418530
41respiratory chain complex IV assembly (GO:0008535)3.86412698
42regulation of mononuclear cell migration (GO:0071675)3.85304626
43myeloid cell activation involved in immune response (GO:0002275)3.82156425
44regulation of mast cell degranulation (GO:0043304)3.77430144
45regulation of mast cell activation (GO:0033003)3.74320650
46negative regulation of mast cell activation (GO:0033004)3.73649516
47detection of molecule of bacterial origin (GO:0032490)3.72631620
48regulation of antigen processing and presentation (GO:0002577)3.69801727
49regulation of interleukin-8 biosynthetic process (GO:0045414)3.69183651
50platelet dense granule organization (GO:0060155)3.65505336
51positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.61448794
52cytochrome complex assembly (GO:0017004)3.61294410
53regulation of mast cell activation involved in immune response (GO:0033006)3.58802844
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.57932582
55DNA methylation involved in gamete generation (GO:0043046)3.57270675
56response to pheromone (GO:0019236)3.56930224
57positive regulation of mast cell activation involved in immune response (GO:0033008)3.55781336
58positive regulation of mast cell degranulation (GO:0043306)3.55781336
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.47645302
60positive regulation of macrophage cytokine production (GO:0060907)3.47482238
61axoneme assembly (GO:0035082)3.46264754
62superoxide anion generation (GO:0042554)3.44230879
63hydrogen peroxide biosynthetic process (GO:0050665)3.43818739
64protein complex biogenesis (GO:0070271)3.43662211
65regulation of leukocyte degranulation (GO:0043300)3.37751941
66neutrophil mediated immunity (GO:0002446)3.35010429
67mannosylation (GO:0097502)3.34997605
68protein-cofactor linkage (GO:0018065)3.34934001
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.34834567
70B cell mediated immunity (GO:0019724)3.32785429
71positive regulation of interferon-beta production (GO:0032728)3.32429563
72cellular response to thyroid hormone stimulus (GO:0097067)3.31483131
73positive regulation of monocyte chemotaxis (GO:0090026)3.31073096
74regulation of myeloid leukocyte mediated immunity (GO:0002886)3.28080299
75Arp2/3 complex-mediated actin nucleation (GO:0034314)3.26819007
76mitochondrial respiratory chain complex assembly (GO:0033108)3.24328251
77protein polyglutamylation (GO:0018095)3.24219556
78negative regulation of telomere maintenance (GO:0032205)3.20103278
79lipopolysaccharide-mediated signaling pathway (GO:0031663)3.15914479
80mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15699629
81mitochondrial respiratory chain complex I assembly (GO:0032981)3.15699629
82NADH dehydrogenase complex assembly (GO:0010257)3.15699629
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.15165213
84positive regulation of leukocyte degranulation (GO:0043302)3.13957726
85positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.13537497
86I-kappaB phosphorylation (GO:0007252)3.13000591
87indolalkylamine metabolic process (GO:0006586)3.11534647
88detection of light stimulus involved in visual perception (GO:0050908)3.10779397
89detection of light stimulus involved in sensory perception (GO:0050962)3.10779397
90lipoxygenase pathway (GO:0019372)3.10400903
91adaptation of signaling pathway (GO:0023058)3.09653689
92response to muramyl dipeptide (GO:0032495)3.09334418
93neutrophil chemotaxis (GO:0030593)3.07200147
94kidney morphogenesis (GO:0060993)3.05083987
95cellular ketone body metabolic process (GO:0046950)3.04574131
96DNA double-strand break processing (GO:0000729)3.03546886
97lymphocyte chemotaxis (GO:0048247)3.03439633
98regulation of glucokinase activity (GO:0033131)3.03311538
99regulation of hexokinase activity (GO:1903299)3.03311538
100preassembly of GPI anchor in ER membrane (GO:0016254)3.02584767
101leukocyte migration involved in inflammatory response (GO:0002523)3.01780179
102leukocyte mediated cytotoxicity (GO:0001909)2.99537257
103neural tube formation (GO:0001841)2.99521258
104cytidine metabolic process (GO:0046087)2.98835159
105cytidine catabolic process (GO:0006216)2.98835159
106cytidine deamination (GO:0009972)2.98835159
107reactive oxygen species biosynthetic process (GO:1903409)2.98598078
108neutrophil migration (GO:1990266)2.98194252
109leukotriene metabolic process (GO:0006691)2.96633369
110positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.96402422
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95930790
112low-density lipoprotein particle clearance (GO:0034383)2.94302247
113phagosome maturation (GO:0090382)2.94065077
114response to thyroid hormone (GO:0097066)2.92728611
115positive regulation of lipid storage (GO:0010884)2.91781836
116positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.91655333
117positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.90692852
118negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89483322
119negative regulation of cell killing (GO:0031342)2.89483322
120T-helper 1 type immune response (GO:0042088)2.88184679
121ketone body metabolic process (GO:1902224)2.88011344
122hyaluronan catabolic process (GO:0030214)2.87714866
123water-soluble vitamin biosynthetic process (GO:0042364)2.86599874
124epithelial cilium movement (GO:0003351)2.86547103
125myeloid leukocyte activation (GO:0002274)2.86186627
126epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.82831572
127regulation of meiosis I (GO:0060631)2.81871693
128interferon-gamma-mediated signaling pathway (GO:0060333)2.81762833
129positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.81569701
130photoreceptor cell maintenance (GO:0045494)2.81244743
131regulation of macrophage cytokine production (GO:0010935)2.80786792
132base-excision repair, AP site formation (GO:0006285)2.79639671
133regulation of monocyte chemotaxis (GO:0090025)2.79556935
134granulocyte chemotaxis (GO:0071621)2.78929523
135negative regulation of interleukin-12 production (GO:0032695)2.78867250
136apoptotic cell clearance (GO:0043277)2.78103913
137positive regulation of defense response to virus by host (GO:0002230)2.77534163
138male meiosis (GO:0007140)2.77345811
139tryptophan catabolic process (GO:0006569)2.76905757
140indole-containing compound catabolic process (GO:0042436)2.76905757
141indolalkylamine catabolic process (GO:0046218)2.76905757
142eosinophil chemotaxis (GO:0048245)2.76808580
143negative regulation of interleukin-6 production (GO:0032715)2.76255696
144positive regulation of T cell migration (GO:2000406)2.75716651
145regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.75441577
146adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.74088332
147negative regulation of granulocyte differentiation (GO:0030853)2.73738980
148leukocyte aggregation (GO:0070486)2.73680354
149positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.72776102
150exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72632966
151negative regulation of transcription regulatory region DNA binding (GO:2000678)2.72494700
152regulation of cilium movement (GO:0003352)2.72420488
153kynurenine metabolic process (GO:0070189)2.71709777
154iron-sulfur cluster assembly (GO:0016226)2.71265233
155metallo-sulfur cluster assembly (GO:0031163)2.71265233
156cornea development in camera-type eye (GO:0061303)2.71195396
157pyrimidine ribonucleoside catabolic process (GO:0046133)2.70675425
158recombinational repair (GO:0000725)2.70164362
159double-strand break repair via homologous recombination (GO:0000724)2.69777195
160gamma-aminobutyric acid transport (GO:0015812)2.69509226
161RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69237570
162positive regulation of oligodendrocyte differentiation (GO:0048714)2.67993264
163retinal cone cell development (GO:0046549)2.67962565
164tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67374453
165RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67374453
166pseudouridine synthesis (GO:0001522)2.65729319
167replication fork processing (GO:0031297)2.63524379
168auditory receptor cell stereocilium organization (GO:0060088)2.61856269
169S-adenosylmethionine metabolic process (GO:0046500)2.61733073
170phosphatidylinositol acyl-chain remodeling (GO:0036149)2.61590068
171regulation of rhodopsin mediated signaling pathway (GO:0022400)2.58525141
172positive regulation of fatty acid transport (GO:2000193)2.55389969
173DNA demethylation (GO:0080111)2.54100324
174inositol phosphate catabolic process (GO:0071545)2.53991483
175positive regulation of prostaglandin secretion (GO:0032308)2.53693491
176regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.52865967
177L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.50322916
178male meiosis I (GO:0007141)2.48603174
179nonmotile primary cilium assembly (GO:0035058)2.48061137
180glycerophospholipid catabolic process (GO:0046475)2.47793939
181cilium morphogenesis (GO:0060271)2.47292824
182centriole replication (GO:0007099)2.47171340
183GPI anchor metabolic process (GO:0006505)2.47053290
184reflex (GO:0060004)2.46272470
185rhodopsin mediated signaling pathway (GO:0016056)2.46201821
186tryptophan metabolic process (GO:0006568)2.45850493
187multicellular organism reproduction (GO:0032504)2.45490157
188photoreceptor cell development (GO:0042461)2.43509447
189cilium movement (GO:0003341)2.43450459
190anterograde synaptic vesicle transport (GO:0048490)2.42219284
191negative regulation of cytosolic calcium ion concentration (GO:0051481)2.40989055
192cell wall macromolecule catabolic process (GO:0016998)2.40721732
193ubiquinone biosynthetic process (GO:0006744)2.39601247
194tachykinin receptor signaling pathway (GO:0007217)2.38819704
195negative regulation of T cell differentiation in thymus (GO:0033085)2.38293140
196reciprocal DNA recombination (GO:0035825)2.38207920
197reciprocal meiotic recombination (GO:0007131)2.38207920
198rRNA catabolic process (GO:0016075)2.37398178
199cilium organization (GO:0044782)2.35820052
200mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.33771871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.03753134
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.93906828
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.42148601
4IRF8_27001747_Chip-Seq_BMDM_Mouse5.12405598
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.91969072
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.44219614
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse4.09416227
8ZNF274_21170338_ChIP-Seq_K562_Hela4.02181405
9VDR_22108803_ChIP-Seq_LS180_Human3.61039608
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.52074693
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.22777207
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.98883883
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.90098924
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.76263287
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74482886
16GBX2_23144817_ChIP-Seq_PC3_Human2.70328615
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68448968
18IGF1R_20145208_ChIP-Seq_DFB_Human2.64368431
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54859034
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.51277830
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.50622658
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46644264
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36263521
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34323832
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33974619
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30252082
27PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.30244277
28SPI1_23547873_ChIP-Seq_NB4_Human2.29824298
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.21320957
30TAF15_26573619_Chip-Seq_HEK293_Human2.18765573
31FLI1_27457419_Chip-Seq_LIVER_Mouse2.15457458
32EGR1_19374776_ChIP-ChIP_THP-1_Human2.13364342
33CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09969262
34GABP_17652178_ChIP-ChIP_JURKAT_Human2.09418186
35EWS_26573619_Chip-Seq_HEK293_Human2.08133406
36VDR_24787735_ChIP-Seq_THP-1_Human2.07358035
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05302517
38SPI1_23127762_ChIP-Seq_K562_Human2.04881160
39P300_19829295_ChIP-Seq_ESCs_Human2.01161335
40ER_23166858_ChIP-Seq_MCF-7_Human1.95671750
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.93089781
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.92934355
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91880974
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90933833
45* PU_27001747_Chip-Seq_BMDM_Mouse1.89308185
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.87906237
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87762922
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.87626160
49FUS_26573619_Chip-Seq_HEK293_Human1.84588690
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83496501
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76266122
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75666368
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74609158
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.73581861
55VDR_24763502_ChIP-Seq_THP-1_Human1.72859239
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.71967773
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70762443
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70601953
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69485313
60RUNX_20019798_ChIP-Seq_JUKART_Human1.65620378
61TP53_22573176_ChIP-Seq_HFKS_Human1.64735028
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63860332
63* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60833342
64BCAT_22108803_ChIP-Seq_LS180_Human1.60526747
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57606943
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.57074008
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.56795976
68CBP_20019798_ChIP-Seq_JUKART_Human1.55822496
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55822496
70* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55551374
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.55420366
72SCL_19346495_ChIP-Seq_HPC-7_Human1.54493303
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53696434
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51823004
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48828195
76GATA1_22025678_ChIP-Seq_K562_Human1.48719490
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46710304
78IRF1_19129219_ChIP-ChIP_H3396_Human1.44883931
79VDR_23849224_ChIP-Seq_CD4+_Human1.43039491
80SOX2_19829295_ChIP-Seq_ESCs_Human1.41755421
81NANOG_19829295_ChIP-Seq_ESCs_Human1.41755421
82MYB_26560356_Chip-Seq_TH2_Human1.41593710
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.41346702
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41095778
85MYC_18940864_ChIP-ChIP_HL60_Human1.40235587
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38576737
87VDR_21846776_ChIP-Seq_THP-1_Human1.36527536
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36000695
89TCF4_22108803_ChIP-Seq_LS180_Human1.35473530
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35144196
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.34313325
92MAF_26560356_Chip-Seq_TH1_Human1.32720809
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32538103
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.31860949
95GATA3_21878914_ChIP-Seq_MCF-7_Human1.31708050
96STAT3_23295773_ChIP-Seq_U87_Human1.31582210
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30935351
98RXR_22158963_ChIP-Seq_LIVER_Mouse1.29628388
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29127030
100ELK1_19687146_ChIP-ChIP_HELA_Human1.28746248
101FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28633320
102FOXA1_25329375_ChIP-Seq_VCAP_Human1.28633320
103TCF4_23295773_ChIP-Seq_U87_Human1.28460024
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27885800
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27810195
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27682894
107SMAD4_21799915_ChIP-Seq_A2780_Human1.27643026
108AR_25329375_ChIP-Seq_VCAP_Human1.27584419
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27249007
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27249007
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26941949
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26659053
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26643860
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25466690
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25161048
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25023670
117LXR_22158963_ChIP-Seq_LIVER_Mouse1.25001379
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24254039
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23778238
120ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23426289
121NFE2_27457419_Chip-Seq_LIVER_Mouse1.22182565
122STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22112544
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.20828952
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19202463
125* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18562237
126EZH2_22144423_ChIP-Seq_EOC_Human1.18406376
127NCOR_22424771_ChIP-Seq_293T_Human1.18311301
128PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17827965
129AR_20517297_ChIP-Seq_VCAP_Human1.17709053
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16340419
131PIAS1_25552417_ChIP-Seq_VCAP_Human1.15163012
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14834303
133HOXB7_26014856_ChIP-Seq_BT474_Human1.14646691
134CRX_20693478_ChIP-Seq_RETINA_Mouse1.13781242
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13702960
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11585885
137TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11426671
138BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11417044
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11180451
140RUNX2_22187159_ChIP-Seq_PCA_Human1.11017918
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10791064
142MYB_26560356_Chip-Seq_TH1_Human1.10066219
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09529718
144SMAD4_21741376_ChIP-Seq_EPCs_Human1.08778823
145SMAD3_21741376_ChIP-Seq_EPCs_Human1.08693374
146CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08257555
147* GATA3_26560356_Chip-Seq_TH2_Human1.08015202
148EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07259883
149AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05402762
150RNF2_27304074_Chip-Seq_NSC_Mouse1.05398487
151ETS1_20019798_ChIP-Seq_JURKAT_Human1.04963346
152NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04322894
153REST_21632747_ChIP-Seq_MESCs_Mouse1.04262856
154CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04250776
155GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04025374
156PRDM14_20953172_ChIP-Seq_ESCs_Human1.03155808
157FOXP3_21729870_ChIP-Seq_TREG_Human1.02800576
158FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01413811
159MYC_19829295_ChIP-Seq_ESCs_Human1.00248067
160GATA3_27048872_Chip-Seq_THYMUS_Human0.99799040
161SRF_21415370_ChIP-Seq_HL-1_Mouse0.99698686
162SPI1_20517297_ChIP-Seq_HL60_Human0.99685297
163FOXH1_21741376_ChIP-Seq_EPCs_Human0.99538815
164EGR1_19032775_ChIP-ChIP_M12_Human0.99024268
165OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98095831
166JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97461401
167GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96266583
168GATA1_19941827_ChIP-Seq_MEL_Mouse0.94241882
169TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94207945
170NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93850673
171NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93850673
172GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93646751
173SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90551299
174UTX_26944678_Chip-Seq_JUKART_Human0.88465503
175SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85180280
176GATA2_19941826_ChIP-Seq_K562_Human0.82361321
177CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82250652
178TCF7_22412390_ChIP-Seq_EML_Mouse0.81939603
179GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81225496
180SOX2_20726797_ChIP-Seq_SW620_Human0.80580220
181CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77900859
182GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77715967
183GATA1_19941826_ChIP-Seq_K562_Human0.77432717
184KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77154319
185IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76917787
186FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75367303
187ELK3_25401928_ChIP-Seq_HUVEC_Human0.73343397
188TFEB_21752829_ChIP-Seq_HELA_Human0.72016564
189PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.71561079
190FOXO3_23340844_ChIP-Seq_DLD1_Human0.69455922
191RARG_19884340_ChIP-ChIP_MEFs_Mouse0.69373238
192CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69270227
193CJUN_26792858_Chip-Seq_BT549_Human0.69050071
194P63_26484246_Chip-Seq_KERATINOCYTES_Human0.68802771
195JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68076674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.83566836
2MP0001835_abnormal_antigen_presentation4.22218701
3MP0003436_decreased_susceptibility_to3.98763857
4MP0008877_abnormal_DNA_methylation3.71222177
5MP0003303_peritoneal_inflammation3.39785663
6MP0002419_abnormal_innate_immunity3.38703146
7MP0003787_abnormal_imprinting3.26218999
8MP0002102_abnormal_ear_morphology3.21921753
9MP0002148_abnormal_hypersensitivity_rea2.97461624
10MP0006082_CNS_inflammation2.84137324
11MP0005000_abnormal_immune_tolerance2.82189143
12MP0003195_calcinosis2.70155800
13MP0009840_abnormal_foam_cell2.68891103
14MP0009785_altered_susceptibility_to2.68483281
15MP0003172_abnormal_lysosome_physiology2.68173534
16MP0005025_abnormal_response_to2.64613872
17MP0004510_myositis2.52322614
18MP0003724_increased_susceptibility_to2.48546206
19MP0005551_abnormal_eye_electrophysiolog2.47887789
20MP0005387_immune_system_phenotype2.47843074
21MP0001790_abnormal_immune_system2.47843074
22MP0002452_abnormal_antigen_presenting2.45417697
23MP0006072_abnormal_retinal_apoptosis2.31308778
24MP0001968_abnormal_touch/_nociception2.30944546
25MP0003191_abnormal_cellular_cholesterol2.30936653
26MP0003690_abnormal_glial_cell2.27122750
27MP0001986_abnormal_taste_sensitivity2.26223198
28MP0001533_abnormal_skeleton_physiology2.25587720
29MP0000372_irregular_coat_pigmentation2.24933353
30MP0001800_abnormal_humoral_immune2.23210549
31MP0000685_abnormal_immune_system2.22463667
32MP0002837_dystrophic_cardiac_calcinosis2.21269341
33MP0002653_abnormal_ependyma_morphology2.13540398
34MP0005646_abnormal_pituitary_gland2.11108018
35MP0005075_abnormal_melanosome_morpholog2.09945197
36MP0000604_amyloidosis2.07723835
37MP0002723_abnormal_immune_serum2.07131569
38MP0005464_abnormal_platelet_physiology2.01972954
39MP0003075_altered_response_to2.00057122
40MP0000343_altered_response_to1.99561920
41MP0005671_abnormal_response_to1.96060568
42MP0002420_abnormal_adaptive_immunity1.94424354
43MP0001819_abnormal_immune_cell1.94399788
44MP0002138_abnormal_hepatobiliary_system1.94043451
45MP0002405_respiratory_system_inflammati1.93006078
46MP0005253_abnormal_eye_physiology1.90617438
47MP0002736_abnormal_nociception_after1.90575939
48MP0001501_abnormal_sleep_pattern1.83301077
49MP0003183_abnormal_peptide_metabolism1.78701984
50MP0001845_abnormal_inflammatory_respons1.78680179
51MP0006292_abnormal_olfactory_placode1.78622079
52MP0005310_abnormal_salivary_gland1.71481054
53MP0003448_altered_tumor_morphology1.65969813
54MP0000569_abnormal_digit_pigmentation1.64353066
55MP0002163_abnormal_gland_morphology1.63533759
56MP0003646_muscle_fatigue1.63208393
57MP0004142_abnormal_muscle_tone1.62563792
58MP0009764_decreased_sensitivity_to1.62079417
59MP0005645_abnormal_hypothalamus_physiol1.62062578
60MP0008469_abnormal_protein_level1.62018181
61MP0008875_abnormal_xenobiotic_pharmacok1.60638054
62MP0009745_abnormal_behavioral_response1.57137484
63MP0002938_white_spotting1.57109665
64MP0003300_gastrointestinal_ulcer1.55718771
65MP0002876_abnormal_thyroid_physiology1.54235122
66MP0002998_abnormal_bone_remodeling1.54148553
67MP0008872_abnormal_physiological_respon1.53910124
68MP0002928_abnormal_bile_duct1.53797345
69MP0005084_abnormal_gallbladder_morpholo1.50822883
70MP0003136_yellow_coat_color1.49555323
71MP0005166_decreased_susceptibility_to1.48818062
72MP0001853_heart_inflammation1.48714299
73MP0009046_muscle_twitch1.46470481
74MP0002272_abnormal_nervous_system1.44430621
75MP0005257_abnormal_intraocular_pressure1.42280293
76MP0001486_abnormal_startle_reflex1.41594764
77MP0004947_skin_inflammation1.39919668
78MP0000465_gastrointestinal_hemorrhage1.39312096
79MP0003121_genomic_imprinting1.38423348
80MP0001485_abnormal_pinna_reflex1.37820744
81MP0005174_abnormal_tail_pigmentation1.35986592
82MP0009333_abnormal_splenocyte_physiolog1.35376421
83MP0010155_abnormal_intestine_physiology1.34013087
84MP0000716_abnormal_immune_system1.33940031
85MP0005379_endocrine/exocrine_gland_phen1.33303403
86MP0006276_abnormal_autonomic_nervous1.32654945
87MP0005167_abnormal_blood-brain_barrier1.32517505
88MP0003828_pulmonary_edema1.31754603
89MP0000427_abnormal_hair_cycle1.31073274
90MP0001984_abnormal_olfaction1.29424377
91MP0004147_increased_porphyrin_level1.28686004
92MP0009278_abnormal_bone_marrow1.27839713
93MP0002095_abnormal_skin_pigmentation1.25148807
94MP0000689_abnormal_spleen_morphology1.24493236
95MP0008058_abnormal_DNA_repair1.23768055
96MP0003011_delayed_dark_adaptation1.22995808
97MP0003880_abnormal_central_pattern1.18589990
98MP0003122_maternal_imprinting1.18455179
99MP0004885_abnormal_endolymph1.17864226
100MP0005410_abnormal_fertilization1.15807448
101MP0004742_abnormal_vestibular_system1.14990244
102MP0004043_abnormal_pH_regulation1.14898337
103MP0001851_eye_inflammation1.12728440
104MP0005389_reproductive_system_phenotype1.12480148
105MP0002398_abnormal_bone_marrow1.11702690
106MP0000858_altered_metastatic_potential1.11116136
107MP0000631_abnormal_neuroendocrine_gland1.09933129
108MP0002277_abnormal_respiratory_mucosa1.09085314
109MP0008995_early_reproductive_senescence1.08946665
110MP0004133_heterotaxia1.08746909
111MP0000015_abnormal_ear_pigmentation1.07309841
112MP0002733_abnormal_thermal_nociception1.06025783
113MP0002429_abnormal_blood_cell1.05917626
114MP0005164_abnormal_response_to1.05726597
115MP0005390_skeleton_phenotype1.04198474
116MP0002572_abnormal_emotion/affect_behav1.04119863
117MP0001764_abnormal_homeostasis1.03933550
118MP0008789_abnormal_olfactory_epithelium1.03908235
119MP0002735_abnormal_chemical_nociception1.01645806
120MP0005397_hematopoietic_system_phenotyp1.01533604
121MP0001545_abnormal_hematopoietic_system1.01533604
122MP0002933_joint_inflammation1.01273858
123MP0003566_abnormal_cell_adhesion1.01060848
124MP0005195_abnormal_posterior_eye1.00995710
125MP0009763_increased_sensitivity_to1.00827689
126MP0010307_abnormal_tumor_latency1.00686325
127MP0001970_abnormal_pain_threshold0.99250233
128MP0002638_abnormal_pupillary_reflex0.98965858
129MP0002722_abnormal_immune_system0.98541077
130MP0005377_hearing/vestibular/ear_phenot0.98280795
131MP0003878_abnormal_ear_physiology0.98280795
132MP0003656_abnormal_erythrocyte_physiolo0.98134537
133MP0004883_abnormal_blood_vessel0.97859378
134MP0002557_abnormal_social/conspecific_i0.97094064
135MP0003786_premature_aging0.96667421
136MP0003718_maternal_effect0.96076000
137MP0004145_abnormal_muscle_electrophysio0.95820616
138MP0005076_abnormal_cell_differentiation0.94870056
139MP0004130_abnormal_muscle_cell0.93954739
140MP0002160_abnormal_reproductive_system0.93603531
141MP0000249_abnormal_blood_vessel0.93442230
142MP0001529_abnormal_vocalization0.93172372
143MP0002166_altered_tumor_susceptibility0.92323859
144MP0003252_abnormal_bile_duct0.91858629
145MP0006036_abnormal_mitochondrial_physio0.91121574
146MP0001905_abnormal_dopamine_level0.90966513
147MP0002064_seizures0.90651163
148MP0010329_abnormal_lipoprotein_level0.90173299
149MP0001929_abnormal_gametogenesis0.88367347
150MP0004782_abnormal_surfactant_physiolog0.87996647
151MP0001919_abnormal_reproductive_system0.86177354
152MP0002234_abnormal_pharynx_morphology0.84994111
153MP0002254_reproductive_system_inflammat0.84696037
154MP0002229_neurodegeneration0.84433468
155MP0002067_abnormal_sensory_capabilities0.84083785
156MP0003795_abnormal_bone_structure0.83576243
157MP0000920_abnormal_myelination0.83563980
158MP0003806_abnormal_nucleotide_metabolis0.83543530
159MP0003698_abnormal_male_reproductive0.83427334
160MP0000516_abnormal_urinary_system0.83034451
161MP0005367_renal/urinary_system_phenotyp0.83034451
162MP0005386_behavior/neurological_phenoty0.81048190
163MP0004924_abnormal_behavior0.81048190
164MP0008260_abnormal_autophagy0.80515024
165MP0006035_abnormal_mitochondrial_morpho0.80309871
166MP0001324_abnormal_eye_pigmentation0.79680534
167MP0002751_abnormal_autonomic_nervous0.78445249
168MP0002210_abnormal_sex_determination0.78440164
169MP0008438_abnormal_cutaneous_collagen0.77460146
170MP0000609_abnormal_liver_physiology0.74660474
171MP0002752_abnormal_somatic_nervous0.74547659
172MP0005083_abnormal_biliary_tract0.73678883
173MP0005085_abnormal_gallbladder_physiolo0.73169714
174MP0002006_tumorigenesis0.72313429
175MP0003186_abnormal_redox_activity0.72216256
176MP0001873_stomach_inflammation0.72186323
177MP0003279_aneurysm0.68458568
178MP0010386_abnormal_urinary_bladder0.67531601
179MP0002136_abnormal_kidney_physiology0.66234190
180MP0001663_abnormal_digestive_system0.65785254
181MP0005319_abnormal_enzyme/_coenzyme0.64537976
182MP0003705_abnormal_hypodermis_morpholog0.62656342
183MP0002090_abnormal_vision0.60954284
184MP0000767_abnormal_smooth_muscle0.60178186
185MP0000490_abnormal_crypts_of0.56893602
186MP0005670_abnormal_white_adipose0.56460237
187MP0005334_abnormal_fat_pad0.54830673
188MP0000598_abnormal_liver_morphology0.53531395
189MP0009115_abnormal_fat_cell0.53118999

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.40738501
2Systemic lupus erythematosus (HP:0002725)7.08569950
3Recurrent bacterial skin infections (HP:0005406)6.46194259
4Recurrent gram-negative bacterial infections (HP:0005420)6.33738053
5Eczematoid dermatitis (HP:0000976)6.27854351
6Vacuolated lymphocytes (HP:0001922)5.92449851
7Increased cerebral lipofuscin (HP:0011813)5.65124821
8Abnormality of macrophages (HP:0004311)5.25842477
9Glomerulonephritis (HP:0000099)5.20923462
10Dysostosis multiplex (HP:0000943)4.81386997
11Increased neuronal autofluorescent lipopigment (HP:0002074)4.72797571
12Pancreatic cysts (HP:0001737)4.44832972
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.27866300
14Abnormality of glycolipid metabolism (HP:0010969)4.27866300
15Abnormality of liposaccharide metabolism (HP:0010968)4.27866300
16Abnormality of midbrain morphology (HP:0002418)4.27621425
17Molar tooth sign on MRI (HP:0002419)4.27621425
18Chronic hepatic failure (HP:0100626)4.11843588
19Pancreatic fibrosis (HP:0100732)4.10764430
20Disinhibition (HP:0000734)4.06980332
21Abnormality of complement system (HP:0005339)4.02290123
22Complement deficiency (HP:0004431)3.95586916
23True hermaphroditism (HP:0010459)3.90886068
24Axonal loss (HP:0003447)3.89115731
25Mucopolysacchariduria (HP:0008155)3.86993900
26Urinary glycosaminoglycan excretion (HP:0003541)3.86993900
27Congenital stationary night blindness (HP:0007642)3.85495088
28Gingivitis (HP:0000230)3.82174509
29Myocardial infarction (HP:0001658)3.80611106
30Recurrent skin infections (HP:0001581)3.79386594
31Mediastinal lymphadenopathy (HP:0100721)3.76153750
32Obstructive lung disease (HP:0006536)3.70536262
33Chronic obstructive pulmonary disease (HP:0006510)3.70536262
34Abnormality of glycosaminoglycan metabolism (HP:0004371)3.66239184
35Abnormality of mucopolysaccharide metabolism (HP:0011020)3.66239184
36Abnormality of polysaccharide metabolism (HP:0011012)3.66239184
37Myositis (HP:0100614)3.47783858
38Nephronophthisis (HP:0000090)3.43807930
39Orchitis (HP:0100796)3.23826602
40Type II lissencephaly (HP:0007260)3.19679229
41Prostate neoplasm (HP:0100787)3.14108807
42Nephritis (HP:0000123)3.12273222
43Recurrent fungal infections (HP:0002841)3.11555351
44Pustule (HP:0200039)3.10142558
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.08126499
46Abolished electroretinogram (ERG) (HP:0000550)3.03403451
47Abnormality of the renal medulla (HP:0100957)3.02752916
48Hepatosplenomegaly (HP:0001433)3.01407987
49Retrobulbar optic neuritis (HP:0100654)2.97976378
50Optic neuritis (HP:0100653)2.97976378
51Abnormality of the renal cortex (HP:0011035)2.96193320
52Loss of speech (HP:0002371)2.95325696
53Acute necrotizing encephalopathy (HP:0006965)2.92652834
54Joint hemorrhage (HP:0005261)2.91436664
55Thick nail (HP:0001805)2.82824087
56Agnosia (HP:0010524)2.82524372
57J-shaped sella turcica (HP:0002680)2.76892616
58Attenuation of retinal blood vessels (HP:0007843)2.73170249
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.72911228
60Periodontitis (HP:0000704)2.72503630
61Cystic liver disease (HP:0006706)2.71601161
62Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.71436420
63Pendular nystagmus (HP:0012043)2.68691239
64Abnormality of the vasculature of the conjunctiva (HP:0008054)2.68642869
65Spontaneous hematomas (HP:0007420)2.67161539
66Increased CSF lactate (HP:0002490)2.67010800
67Urticaria (HP:0001025)2.66550102
68Mitochondrial inheritance (HP:0001427)2.65599962
69Abnormal rod and cone electroretinograms (HP:0008323)2.64658431
70Progressive macrocephaly (HP:0004481)2.63566187
71Medial flaring of the eyebrow (HP:0010747)2.61673810
72Stomatitis (HP:0010280)2.61358971
73Upper motor neuron abnormality (HP:0002127)2.53138159
743-Methylglutaconic aciduria (HP:0003535)2.52847669
75Abnormal mitochondria in muscle tissue (HP:0008316)2.49176806
76Acute encephalopathy (HP:0006846)2.48791332
77Conjunctival telangiectasia (HP:0000524)2.47626171
78Cellulitis (HP:0100658)2.46699253
79Hematochezia (HP:0002573)2.41844166
80Autoimmune thrombocytopenia (HP:0001973)2.41242265
81Hepatocellular necrosis (HP:0001404)2.40173193
82Abnormality of the labia minora (HP:0012880)2.40008016
83Abnormality of the lumbar spine (HP:0100712)2.39838189
84Retinal dysplasia (HP:0007973)2.37796345
85Intestinal atresia (HP:0011100)2.37507238
86Tubular atrophy (HP:0000092)2.36314086
87Keratoconus (HP:0000563)2.34097564
88Increased corneal curvature (HP:0100692)2.34097564
89Gaze-evoked nystagmus (HP:0000640)2.31856879
90Elevated erythrocyte sedimentation rate (HP:0003565)2.31594852
91Pathologic fracture (HP:0002756)2.31240429
92Recurrent viral infections (HP:0004429)2.30877225
93Decreased central vision (HP:0007663)2.30370689
94Thoracic kyphosis (HP:0002942)2.29403665
95Sclerocornea (HP:0000647)2.29170366
96Osteomyelitis (HP:0002754)2.26224027
97Hyperventilation (HP:0002883)2.25034242
98Osteolytic defects of the hand bones (HP:0009699)2.23938695
99Osteolytic defects of the phalanges of the hand (HP:0009771)2.23938695
100Meningitis (HP:0001287)2.22975519
101Aplasia/Hypoplasia of the tongue (HP:0010295)2.22834090
102Asymmetric septal hypertrophy (HP:0001670)2.22786473
103Hypercholesterolemia (HP:0003124)2.22758643
104Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21741668
105Polydipsia (HP:0001959)2.21647146
106Abnormal drinking behavior (HP:0030082)2.21647146
107Basal ganglia calcification (HP:0002135)2.20490275
108Hepatic necrosis (HP:0002605)2.19091107
109Nausea (HP:0002018)2.18785598
110Recurrent pneumonia (HP:0006532)2.18493802
111Optic disc pallor (HP:0000543)2.16653839
112Peripheral demyelination (HP:0011096)2.15586039
113Inability to walk (HP:0002540)2.15449128
114Chronic mucocutaneous candidiasis (HP:0002728)2.15288429
115Recurrent cutaneous fungal infections (HP:0011370)2.15288429
116Pulmonary infiltrates (HP:0002113)2.14217590
117Petechiae (HP:0000967)2.14090450
118Xanthomatosis (HP:0000991)2.13359104
119Neoplasm of the adrenal cortex (HP:0100641)2.12239255
120Stomach cancer (HP:0012126)2.11448085
121Constricted visual fields (HP:0001133)2.11427731
122Abnormal biliary tract physiology (HP:0012439)2.09289255
123Bile duct proliferation (HP:0001408)2.09289255
124Anencephaly (HP:0002323)2.09227643
125Lissencephaly (HP:0001339)2.09052188
126Vasculitis (HP:0002633)2.08111764
127Prolonged bleeding time (HP:0003010)2.06274239
128Inappropriate behavior (HP:0000719)2.05962575
129Renal cortical cysts (HP:0000803)2.05531039
130Thyroid-stimulating hormone excess (HP:0002925)2.04453354
131Neurofibrillary tangles (HP:0002185)2.04257416
132Congenital hepatic fibrosis (HP:0002612)2.03813356
133Progressive visual loss (HP:0000529)2.03202085
134Bone pain (HP:0002653)2.03139295
135Arterial thrombosis (HP:0004420)2.03020892
136Colon cancer (HP:0003003)2.02633122
137Concave nail (HP:0001598)2.01806797
138Hypothermia (HP:0002045)2.01193662
139Nephrogenic diabetes insipidus (HP:0009806)2.00749857
140Diminished motivation (HP:0000745)2.00193256
141Gingival bleeding (HP:0000225)1.99387020
142Thyroiditis (HP:0100646)1.98934054
143Furrowed tongue (HP:0000221)1.98375861
144Progressive inability to walk (HP:0002505)1.97546300
145Cerebellar dysplasia (HP:0007033)1.96199147
146Apathy (HP:0000741)1.96190078
147Leukocytosis (HP:0001974)1.95068022
148Gait imbalance (HP:0002141)1.94266759
149Absent speech (HP:0001344)1.94120462
150Colitis (HP:0002583)1.93779213
151Mutism (HP:0002300)1.93507927
152Male pseudohermaphroditism (HP:0000037)1.93166742
153Anorexia (HP:0002039)1.92481196
154Hypomagnesemia (HP:0002917)1.91241524
155Polyuria (HP:0000103)1.89723391
156Congenital primary aphakia (HP:0007707)1.89550351
157Focal motor seizures (HP:0011153)1.89484174
158Inflammation of the large intestine (HP:0002037)1.88992237
159Aplasia/Hypoplasia of the tibia (HP:0005772)1.88341060
160Interstitial pulmonary disease (HP:0006530)1.87731551
161Hypokinesia (HP:0002375)1.86198771
162Global brain atrophy (HP:0002283)1.86086740
163Bony spicule pigmentary retinopathy (HP:0007737)1.85102296
164Abnormality of the prostate (HP:0008775)1.84396500
165Keratoconjunctivitis sicca (HP:0001097)1.83137786
166Broad-based gait (HP:0002136)1.82311032
167Abnormality of macular pigmentation (HP:0008002)1.81817754
168Vertebral compression fractures (HP:0002953)1.81109952
169Cerebral edema (HP:0002181)1.80955137
170Hyperlipoproteinemia (HP:0010980)1.80739243
171Type I transferrin isoform profile (HP:0003642)1.80720317
172Hemiparesis (HP:0001269)1.79436300
173Febrile seizures (HP:0002373)1.79258444
174IgG deficiency (HP:0004315)1.79142710
175Neuronal loss in central nervous system (HP:0002529)1.79080816
176Severe visual impairment (HP:0001141)1.79009230
177Increased serum lactate (HP:0002151)1.77781843
178Optic nerve hypoplasia (HP:0000609)1.77752437
179Esophageal varix (HP:0002040)1.77495752
180Postaxial foot polydactyly (HP:0001830)1.77109816
181Mucosal telangiectasiae (HP:0100579)1.76840197
182Aplasia/hypoplasia of the uterus (HP:0008684)1.75458364
183Large for gestational age (HP:0001520)1.73821632
184Pachygyria (HP:0001302)1.72740533
185Abnormal protein glycosylation (HP:0012346)1.72262173
186Abnormal glycosylation (HP:0012345)1.72262173
187Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72262173
188Abnormal protein N-linked glycosylation (HP:0012347)1.72262173
189Abnormal albumin level (HP:0012116)1.70978427
190Hypoalbuminemia (HP:0003073)1.70978427
191Postaxial hand polydactyly (HP:0001162)1.70621919
192Agitation (HP:0000713)1.69578108
193Genital tract atresia (HP:0001827)1.68054931
194Severe muscular hypotonia (HP:0006829)1.67762823
195Hypoproteinemia (HP:0003075)1.67138305
196Albinism (HP:0001022)1.66900245
197Occipital encephalocele (HP:0002085)1.66249822
198Aplasia/Hypoplasia of the fovea (HP:0008060)1.65277014
199Hypoplasia of the fovea (HP:0007750)1.65277014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.89836148
2BLK4.60911598
3RIPK43.93316306
4IRAK43.77493035
5MAP3K143.28718281
6TYK23.17209840
7GRK12.82872703
8TBK12.69725532
9KIT2.65134397
10TAOK32.61587002
11TGFBR22.39124402
12ZAK2.37440718
13MAP4K22.36951980
14IRAK32.36465251
15PBK2.28405850
16PINK12.21289019
17WNK32.20075061
18GRK72.14257957
19BCKDK2.10766318
20ACVR1B2.06507254
21ERN12.02285207
22MAP4K12.01435050
23EIF2AK32.01360390
24FGR1.97445722
25CSF1R1.83711208
26MAPK131.82031381
27FES1.81958369
28TRIM281.78930449
29IKBKB1.78437033
30CSK1.73662005
31JAK11.69354117
32INSRR1.66145452
33NEK91.61394302
34IKBKE1.60884318
35HCK1.53019137
36TIE11.52370380
37VRK21.50297693
38EPHB11.50178538
39BTK1.48879206
40STK101.45458096
41CAMK1D1.44802019
42PIM21.44639241
43MST41.44581118
44OXSR11.38601870
45ZAP701.37456964
46TXK1.36416899
47RIPK11.35908346
48LYN1.35051230
49SYK1.34815910
50STK38L1.33814111
51WNK41.33462052
52CASK1.29923501
53NME21.28421906
54TNIK1.23198340
55TEC1.23141616
56MKNK21.22909309
57TAF11.22626478
58DYRK21.21778768
59TLK11.21730577
60JAK21.16971143
61LCK1.16246755
62CLK11.14821681
63MAP2K31.09665011
64PLK21.08113318
65ABL21.06281217
66SIK21.06055085
67MAP3K41.05988470
68BMX1.05853670
69JAK31.05774816
70STK391.04796402
71PAK31.00642076
72NLK0.96173434
73MAP3K130.95638690
74ADRBK10.95514327
75PRKCE0.93096840
76EGFR0.92877152
77BMPR20.90677554
78TTN0.90018942
79MATK0.89557554
80MARK10.88825122
81TGFBR10.88100808
82STK160.87964345
83TRIB30.87771612
84CHUK0.86730194
85BCR0.86599004
86CAMK1G0.85350724
87VRK10.84886172
88CDK60.83430085
89MARK30.81478964
90MOS0.81322365
91YES10.80496856
92NTRK30.80052619
93CSNK1G10.79995425
94PLK40.79364942
95PNCK0.79342965
96TRPM70.79230809
97PRKCD0.77341657
98PIM10.77251070
99ABL10.76186485
100MAP3K30.73328715
101MKNK10.72602116
102ITK0.72588351
103CAMKK20.71285660
104PLK30.70594088
105GRK60.70286592
106ADRBK20.70023401
107PHKG20.69178260
108PHKG10.69178260
109CSNK1G30.68541411
110EIF2AK20.68430852
111MST1R0.66741271
112CSNK1G20.65719997
113PKN20.65694535
114MAPKAPK30.64836339
115MAP2K70.63702436
116STK40.63424936
117CSNK1A1L0.62155607
118LATS10.61724536
119MAP3K110.61169972
120CAMKK10.61035155
121PTK60.60427335
122PRKCG0.59759799
123STK30.57666743
124PAK40.56115300
125EIF2AK10.55855701
126FYN0.55123588
127PRKCI0.53178966
128SCYL20.52182824
129GRK50.51697643
130LRRK20.51237055
131MAP2K60.51141457
132STK110.50379116
133MAP2K20.48219767
134MAPKAPK20.45820344
135IGF1R0.45718540
136PIK3CG0.44989270
137PRKACA0.44877817
138TESK20.44411385
139DYRK1A0.44343826
140DAPK20.43085283
141BRSK20.42645266
142CAMK2A0.42471958
143ERBB30.42295086
144RPS6KA50.42023127
145FGFR20.41820973
146SIK30.41755151
147CSNK1A10.41406089
148FGFR30.40996708
149IRAK10.40930837
150PRKCZ0.40768183
151RPS6KA60.40587558
152STK380.40077178
153RPS6KA40.39618603
154CDC70.39585110
155PRKCH0.39537085
156PDGFRB0.39101682
157PRKCQ0.38870275
158RPS6KL10.37822303
159RPS6KC10.37822303
160MAPKAPK50.36903781
161NME10.36840756
162PLK10.35870006
163ATR0.35476668
164NTRK20.35313674
165EPHA40.34996112
166DYRK1B0.34218868
167STK240.33764231
168MAPK40.33716366
169CDK90.33296377
170GSK3A0.32477217
171BMPR1B0.31403553
172PDK10.31132344
173TNK20.30769811
174PKN10.29727221
175PTK2B0.27709083
176MET0.27343429
177NUAK10.27143167

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.44647031
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.58338892
3Lysosome_Homo sapiens_hsa041423.52578598
4Leishmaniasis_Homo sapiens_hsa051403.27819446
5Other glycan degradation_Homo sapiens_hsa005113.06735215
6Phototransduction_Homo sapiens_hsa047442.87175879
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.62595862
8Oxidative phosphorylation_Homo sapiens_hsa001902.61924090
9Pertussis_Homo sapiens_hsa051332.59570926
10Osteoclast differentiation_Homo sapiens_hsa043802.58104063
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.49341464
12Tuberculosis_Homo sapiens_hsa051522.47770443
13Phagosome_Homo sapiens_hsa041452.47171098
14Linoleic acid metabolism_Homo sapiens_hsa005912.46747815
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46490385
16Complement and coagulation cascades_Homo sapiens_hsa046102.41321606
17Toll-like receptor signaling pathway_Homo sapiens_hsa046202.37085181
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34761628
19Protein export_Homo sapiens_hsa030602.26655111
20Maturity onset diabetes of the young_Homo sapiens_hsa049502.23826698
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20929471
22Legionellosis_Homo sapiens_hsa051342.16725172
23Nitrogen metabolism_Homo sapiens_hsa009102.12782130
24Malaria_Homo sapiens_hsa051442.09084502
25Parkinsons disease_Homo sapiens_hsa050122.06167057
26Butanoate metabolism_Homo sapiens_hsa006502.00501669
27RNA polymerase_Homo sapiens_hsa030201.96020088
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94699881
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.92605492
30Rheumatoid arthritis_Homo sapiens_hsa053231.87177930
31Homologous recombination_Homo sapiens_hsa034401.81709890
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79616542
33Proteasome_Homo sapiens_hsa030501.76551588
34Fanconi anemia pathway_Homo sapiens_hsa034601.74447378
35Basal transcription factors_Homo sapiens_hsa030221.73830775
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71143975
37Caffeine metabolism_Homo sapiens_hsa002321.68899959
38B cell receptor signaling pathway_Homo sapiens_hsa046621.64103828
39Salmonella infection_Homo sapiens_hsa051321.57727399
40Selenocompound metabolism_Homo sapiens_hsa004501.48904252
41RNA degradation_Homo sapiens_hsa030181.48112139
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47280932
43Antigen processing and presentation_Homo sapiens_hsa046121.44909883
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43575100
45Measles_Homo sapiens_hsa051621.41408401
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41384491
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39916406
48Peroxisome_Homo sapiens_hsa041461.38719538
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38522705
50Huntingtons disease_Homo sapiens_hsa050161.36837627
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36386189
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34645473
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33568758
54Toxoplasmosis_Homo sapiens_hsa051451.32927221
55Propanoate metabolism_Homo sapiens_hsa006401.28533198
56Hematopoietic cell lineage_Homo sapiens_hsa046401.27363318
57Olfactory transduction_Homo sapiens_hsa047401.25788131
58Shigellosis_Homo sapiens_hsa051311.25105514
59Type I diabetes mellitus_Homo sapiens_hsa049401.24170122
60Chemokine signaling pathway_Homo sapiens_hsa040621.23588045
61Nicotine addiction_Homo sapiens_hsa050331.20927744
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.19781245
63Tryptophan metabolism_Homo sapiens_hsa003801.17878498
64Apoptosis_Homo sapiens_hsa042101.16976899
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16247627
66Regulation of autophagy_Homo sapiens_hsa041401.15917098
67Alzheimers disease_Homo sapiens_hsa050101.13592516
68Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13293313
69Influenza A_Homo sapiens_hsa051641.11907412
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10256360
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10045085
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09473802
73Taste transduction_Homo sapiens_hsa047421.08926702
74Asthma_Homo sapiens_hsa053101.07390391
75Leukocyte transendothelial migration_Homo sapiens_hsa046701.06346737
76Steroid hormone biosynthesis_Homo sapiens_hsa001401.06142549
77TNF signaling pathway_Homo sapiens_hsa046681.03669134
78Non-homologous end-joining_Homo sapiens_hsa034501.02274830
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99831753
80Morphine addiction_Homo sapiens_hsa050320.99205542
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98936999
82Graft-versus-host disease_Homo sapiens_hsa053320.98651136
83Sphingolipid metabolism_Homo sapiens_hsa006000.94065613
84Amoebiasis_Homo sapiens_hsa051460.93759409
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91884047
86Cardiac muscle contraction_Homo sapiens_hsa042600.91158648
87Retinol metabolism_Homo sapiens_hsa008300.90229659
88Prion diseases_Homo sapiens_hsa050200.88606820
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88381359
90Chemical carcinogenesis_Homo sapiens_hsa052040.88304630
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88079684
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88066453
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.87437309
94Collecting duct acid secretion_Homo sapiens_hsa049660.86603327
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84896981
96One carbon pool by folate_Homo sapiens_hsa006700.84665902
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82507069
98Herpes simplex infection_Homo sapiens_hsa051680.79614839
99Serotonergic synapse_Homo sapiens_hsa047260.79085356
100Purine metabolism_Homo sapiens_hsa002300.79029804
101Hepatitis B_Homo sapiens_hsa051610.78511809
102Allograft rejection_Homo sapiens_hsa053300.74016026
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.72868945
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69482271
105African trypanosomiasis_Homo sapiens_hsa051430.68014860
106Ovarian steroidogenesis_Homo sapiens_hsa049130.67760513
107Viral myocarditis_Homo sapiens_hsa054160.67533868
108Base excision repair_Homo sapiens_hsa034100.65422688
109Hepatitis C_Homo sapiens_hsa051600.65392927
110Pyrimidine metabolism_Homo sapiens_hsa002400.64051643
111GABAergic synapse_Homo sapiens_hsa047270.64013614
112Metabolic pathways_Homo sapiens_hsa011000.63397152
113PPAR signaling pathway_Homo sapiens_hsa033200.63054654
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62216274
115Platelet activation_Homo sapiens_hsa046110.61589134
116Renin-angiotensin system_Homo sapiens_hsa046140.60793767
117Endocytosis_Homo sapiens_hsa041440.59989056
118Circadian entrainment_Homo sapiens_hsa047130.59610661
119Steroid biosynthesis_Homo sapiens_hsa001000.58234939
120Histidine metabolism_Homo sapiens_hsa003400.57881588
121Fatty acid elongation_Homo sapiens_hsa000620.57660141
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55397999
123Dorso-ventral axis formation_Homo sapiens_hsa043200.55115076
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54668008
125Glutamatergic synapse_Homo sapiens_hsa047240.54357081
126Insulin secretion_Homo sapiens_hsa049110.54263055
127Fat digestion and absorption_Homo sapiens_hsa049750.53122044
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52889562
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52614382
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.51378852
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50724405
132Pancreatic cancer_Homo sapiens_hsa052120.50094073
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48609071
134Fatty acid degradation_Homo sapiens_hsa000710.48543730
135Salivary secretion_Homo sapiens_hsa049700.48080843
136Mineral absorption_Homo sapiens_hsa049780.47872824
137Primary immunodeficiency_Homo sapiens_hsa053400.47486442
138T cell receptor signaling pathway_Homo sapiens_hsa046600.45099819
139Starch and sucrose metabolism_Homo sapiens_hsa005000.44160265
140Chronic myeloid leukemia_Homo sapiens_hsa052200.44139082
141Acute myeloid leukemia_Homo sapiens_hsa052210.43959654
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43297603
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43133275
144Vitamin digestion and absorption_Homo sapiens_hsa049770.39471880
145Arachidonic acid metabolism_Homo sapiens_hsa005900.39202944
146ABC transporters_Homo sapiens_hsa020100.39010651
147Fatty acid metabolism_Homo sapiens_hsa012120.38570613
148Sulfur metabolism_Homo sapiens_hsa009200.38184361
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.36770370
150Nucleotide excision repair_Homo sapiens_hsa034200.36555160
151Ribosome_Homo sapiens_hsa030100.36157924
152p53 signaling pathway_Homo sapiens_hsa041150.35731369
153Galactose metabolism_Homo sapiens_hsa000520.34236647
154Neurotrophin signaling pathway_Homo sapiens_hsa047220.33060826
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33036085
156Arginine biosynthesis_Homo sapiens_hsa002200.31996664
157Sphingolipid signaling pathway_Homo sapiens_hsa040710.31462655
158Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31095391
159Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28136091
160Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27273009
161Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26519327
162HIF-1 signaling pathway_Homo sapiens_hsa040660.24693032
163Proteoglycans in cancer_Homo sapiens_hsa052050.23873566
164Viral carcinogenesis_Homo sapiens_hsa052030.21399327
165Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21285872
166Vibrio cholerae infection_Homo sapiens_hsa051100.21004438
167Ether lipid metabolism_Homo sapiens_hsa005650.20459264
168Prolactin signaling pathway_Homo sapiens_hsa049170.19299133
169Autoimmune thyroid disease_Homo sapiens_hsa053200.19137109
170beta-Alanine metabolism_Homo sapiens_hsa004100.18982099
171Insulin resistance_Homo sapiens_hsa049310.17394323
172Epstein-Barr virus infection_Homo sapiens_hsa051690.17236005

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »