CD320

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mitochondrial translation (GO:0070129)5.63592960
2DNA deamination (GO:0045006)5.47804705
3purine nucleobase biosynthetic process (GO:0009113)5.34793793
4protein maturation by protein folding (GO:0022417)5.10223377
5nucleobase biosynthetic process (GO:0046112)5.09404757
6maturation of SSU-rRNA (GO:0030490)4.74867248
7ribosome assembly (GO:0042255)4.67411923
8formation of translation preinitiation complex (GO:0001731)4.52147030
9transcription elongation from RNA polymerase III promoter (GO:0006385)4.47793214
10termination of RNA polymerase III transcription (GO:0006386)4.47793214
11ribosome biogenesis (GO:0042254)4.47193145
12mitotic metaphase plate congression (GO:0007080)4.33286671
13proteasome assembly (GO:0043248)4.30918533
14DNA replication checkpoint (GO:0000076)4.25682108
15chaperone-mediated protein transport (GO:0072321)4.23671982
16ribosomal large subunit biogenesis (GO:0042273)4.20561428
17ribonucleoprotein complex biogenesis (GO:0022613)4.16472080
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.08207356
19spliceosomal snRNP assembly (GO:0000387)4.01098932
20rRNA modification (GO:0000154)3.98312034
21folic acid metabolic process (GO:0046655)3.91407071
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.90180367
23protein targeting to mitochondrion (GO:0006626)3.86028832
24ribosomal small subunit assembly (GO:0000028)3.84782449
25DNA strand elongation involved in DNA replication (GO:0006271)3.82182858
26DNA replication initiation (GO:0006270)3.82131056
27pseudouridine synthesis (GO:0001522)3.76839977
28rRNA processing (GO:0006364)3.76827781
29viral transcription (GO:0019083)3.76062847
30translational termination (GO:0006415)3.75587986
31translational initiation (GO:0006413)3.75188895
32pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.75002234
337-methylguanosine mRNA capping (GO:0006370)3.69779773
34rRNA metabolic process (GO:0016072)3.66852134
35DNA strand elongation (GO:0022616)3.65900504
36establishment of protein localization to mitochondrion (GO:0072655)3.65192898
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64469609
38transcription elongation from RNA polymerase I promoter (GO:0006362)3.62039679
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.61667948
40transcription from RNA polymerase I promoter (GO:0006360)3.61384613
41RNA capping (GO:0036260)3.61090470
427-methylguanosine RNA capping (GO:0009452)3.61090470
43termination of RNA polymerase I transcription (GO:0006363)3.60458633
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.60219849
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59827878
46ribosomal small subunit biogenesis (GO:0042274)3.58710855
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57475878
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.56305843
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.54894647
50UTP biosynthetic process (GO:0006228)3.54651363
51pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.53194678
52energy coupled proton transport, down electrochemical gradient (GO:0015985)3.51960800
53ATP synthesis coupled proton transport (GO:0015986)3.51960800
54metaphase plate congression (GO:0051310)3.51018639
55translational elongation (GO:0006414)3.50782739
56proline biosynthetic process (GO:0006561)3.48998026
57signal transduction involved in cell cycle checkpoint (GO:0072395)3.48059628
58telomere maintenance via semi-conservative replication (GO:0032201)3.46897586
59DNA unwinding involved in DNA replication (GO:0006268)3.46498832
60guanosine-containing compound biosynthetic process (GO:1901070)3.45597564
61peptidyl-arginine omega-N-methylation (GO:0035247)3.45287415
62pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.44941621
63establishment of viral latency (GO:0019043)3.43339240
64peptidyl-histidine modification (GO:0018202)3.41349352
65DNA replication-dependent nucleosome assembly (GO:0006335)3.40707318
66DNA replication-dependent nucleosome organization (GO:0034723)3.40707318
67CENP-A containing nucleosome assembly (GO:0034080)3.40292018
68mitochondrial respiratory chain complex assembly (GO:0033108)3.40195361
69GDP-mannose metabolic process (GO:0019673)3.39970637
70regulation of translational termination (GO:0006449)3.38466303
71protein complex biogenesis (GO:0070271)3.38369580
72GTP biosynthetic process (GO:0006183)3.38263922
73regulation of spindle organization (GO:0090224)3.37587139
74histone arginine methylation (GO:0034969)3.37049317
75transcription-coupled nucleotide-excision repair (GO:0006283)3.36795248
76establishment of integrated proviral latency (GO:0075713)3.36159739
77chromatin remodeling at centromere (GO:0031055)3.35933280
78protein localization to mitochondrion (GO:0070585)3.35678955
79CTP biosynthetic process (GO:0006241)3.32802854
80CTP metabolic process (GO:0046036)3.32802854
81mitotic nuclear envelope reassembly (GO:0007084)3.31234976
82nuclear envelope reassembly (GO:0031468)3.31234976
83negative regulation of ligase activity (GO:0051352)3.31151032
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31151032
85cellular component biogenesis (GO:0044085)3.30846905
86mitochondrial RNA metabolic process (GO:0000959)3.30597482
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27055701
88regulation of translational fidelity (GO:0006450)3.27003552
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.26771579
90pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.26268142
91translation (GO:0006412)3.24944436
92regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23185072
93respiratory electron transport chain (GO:0022904)3.22835693
94mitotic nuclear envelope disassembly (GO:0007077)3.22274452
95DNA replication-independent nucleosome assembly (GO:0006336)3.21181329
96DNA replication-independent nucleosome organization (GO:0034724)3.21181329
97regulation of ligase activity (GO:0051340)3.19656036
98cotranslational protein targeting to membrane (GO:0006613)3.19127734
99protein targeting to ER (GO:0045047)3.17604169
100cytochrome complex assembly (GO:0017004)3.17600501
101histone exchange (GO:0043486)3.17543096
102spliceosomal complex assembly (GO:0000245)3.17444187
103pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.17345962
104UTP metabolic process (GO:0046051)3.16506559
105electron transport chain (GO:0022900)3.16135284
106protein localization to kinetochore (GO:0034501)3.16117756
107nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15147783
108iron-sulfur cluster assembly (GO:0016226)3.14783555
109metallo-sulfur cluster assembly (GO:0031163)3.14783555
110mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14309780
111transcription initiation from RNA polymerase I promoter (GO:0006361)3.14180843
112maturation of 5.8S rRNA (GO:0000460)3.12815640
113negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.11119134
114protein K6-linked ubiquitination (GO:0085020)3.10682209
115telomere maintenance via recombination (GO:0000722)3.10328552
116L-serine metabolic process (GO:0006563)3.09672788
117positive regulation of ligase activity (GO:0051351)3.09592895
118base-excision repair, AP site formation (GO:0006285)3.09431098
119nucleobase-containing small molecule interconversion (GO:0015949)3.08337184
120transcription from mitochondrial promoter (GO:0006390)3.08027649
121L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07277047
122cullin deneddylation (GO:0010388)3.06856139
123protein localization to endoplasmic reticulum (GO:0070972)3.06467136
124viral mRNA export from host cell nucleus (GO:0046784)3.04819147
125rRNA methylation (GO:0031167)3.04548771
126cellular protein complex disassembly (GO:0043624)3.04531899
127DNA-templated transcription, elongation (GO:0006354)3.03565071
128transcription elongation from RNA polymerase II promoter (GO:0006368)3.02639555
129respiratory chain complex IV assembly (GO:0008535)3.02495103
130protein deneddylation (GO:0000338)3.02103783
131establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01939384
132positive regulation of cell cycle arrest (GO:0071158)2.99009035
133protein localization to chromosome, centromeric region (GO:0071459)2.98542003
134IMP biosynthetic process (GO:0006188)2.98293167
135nuclear envelope disassembly (GO:0051081)2.97779786
136membrane disassembly (GO:0030397)2.97779786
137regulation of ubiquitin-protein transferase activity (GO:0051438)2.97502794
138GMP metabolic process (GO:0046037)2.97224200
139G1/S transition of mitotic cell cycle (GO:0000082)2.97116197
140cell cycle G1/S phase transition (GO:0044843)2.97116197
141ncRNA 3-end processing (GO:0043628)2.96483799
142mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96172709
143mitochondrial respiratory chain complex I assembly (GO:0032981)2.96172709
144NADH dehydrogenase complex assembly (GO:0010257)2.96172709
145regulation of cellular amino acid metabolic process (GO:0006521)2.94437595
146signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.94213809
147signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.94213809
148signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.94213809
149DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93889057
150blastocyst development (GO:0001824)2.92628245
151spindle checkpoint (GO:0031577)2.92453051
152signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91895487
153intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91895487
154regulation of translation in response to stress (GO:0043555)2.91668816
155signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91665730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.94419787
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.54623723
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81464665
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.67975566
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.60059163
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.48332925
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.41158844
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.33055991
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.30874802
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.28532068
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20503423
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.20480253
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11290761
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99477424
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77613456
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.70436683
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58568008
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51413138
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.51065999
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49308995
21XRN2_22483619_ChIP-Seq_HELA_Human2.47900714
22* VDR_23849224_ChIP-Seq_CD4+_Human2.46473040
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41194199
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36817453
25DCP1A_22483619_ChIP-Seq_HELA_Human2.24954872
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22840898
27* GABP_19822575_ChIP-Seq_HepG2_Human2.21083853
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16182492
29MYCN_18555785_ChIP-Seq_MESCs_Mouse2.07501719
30* FOXP3_21729870_ChIP-Seq_TREG_Human2.04987195
31AR_21909140_ChIP-Seq_LNCAP_Human1.98747667
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96735065
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.96483463
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93488845
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93395863
36TTF2_22483619_ChIP-Seq_HELA_Human1.91681412
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81926461
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78903089
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73254175
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72749901
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67834496
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65175099
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62344313
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.62331085
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61387923
46KDM5A_27292631_Chip-Seq_BREAST_Human1.56265687
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56253041
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.54083900
49CIITA_25753668_ChIP-Seq_RAJI_Human1.49055286
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45503816
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44367364
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.44301632
53ELK1_19687146_ChIP-ChIP_HELA_Human1.44015232
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37106803
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36221161
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32741842
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32593288
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32450266
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31849851
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29828048
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29268786
62* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25729146
63* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24301524
64ZNF263_19887448_ChIP-Seq_K562_Human1.24059011
65* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23271816
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23025171
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22909712
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21210235
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.20713134
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19093269
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18053422
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17709022
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17231334
74* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16747880
75* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16705763
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15648138
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.14588521
78* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13498930
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13364613
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11398360
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11308009
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09964519
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09701863
84* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08546293
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07179329
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06523251
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06470610
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05824790
89P68_20966046_ChIP-Seq_HELA_Human1.05484169
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05165986
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00827607
92* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00380717
93LXR_22292898_ChIP-Seq_THP-1_Human0.99854636
94VDR_21846776_ChIP-Seq_THP-1_Human0.99507033
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97554625
96* ELF1_20517297_ChIP-Seq_JURKAT_Human0.97137846
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.96104062
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.95713518
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95528428
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94333702
101TFEB_21752829_ChIP-Seq_HELA_Human0.91947957
102MYC_18940864_ChIP-ChIP_HL60_Human0.91298850
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88776420
104BCL6_27268052_Chip-Seq_Bcells_Human0.88536045
105TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88011984
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86887456
107SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86674137
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.84254738
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81313744
110YY1_22570637_ChIP-Seq_MALME-3M_Human0.80785840
111FOXP1_21924763_ChIP-Seq_HESCs_Human0.80669296
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80477862
113CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80081490
114OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78105481
115TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77736712
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.77188968
117TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76943963
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75383499
119MYC_22102868_ChIP-Seq_BL_Human0.74580225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.12020985
2MP0004957_abnormal_blastocyst_morpholog4.61450125
3MP0003111_abnormal_nucleus_morphology4.49597724
4MP0010094_abnormal_chromosome_stability4.02799246
5MP0003077_abnormal_cell_cycle3.82500062
6MP0008057_abnormal_DNA_replication3.48394465
7MP0008058_abnormal_DNA_repair3.48022316
8MP0003718_maternal_effect3.06331776
9MP0008932_abnormal_embryonic_tissue2.90594149
10MP0003123_paternal_imprinting2.79866368
11MP0008007_abnormal_cellular_replicative2.76487300
12MP0003786_premature_aging2.60648482
13MP0008877_abnormal_DNA_methylation2.50232386
14MP0001730_embryonic_growth_arrest2.39879182
15MP0002210_abnormal_sex_determination2.04179140
16MP0001929_abnormal_gametogenesis2.03076516
17MP0000350_abnormal_cell_proliferation1.99993783
18MP0005670_abnormal_white_adipose1.98210943
19MP0001145_abnormal_male_reproductive1.86733399
20MP0001672_abnormal_embryogenesis/_devel1.86333850
21MP0005380_embryogenesis_phenotype1.86333850
22MP0005410_abnormal_fertilization1.84383117
23MP0003315_abnormal_perineum_morphology1.78263304
24MP0000372_irregular_coat_pigmentation1.74205343
25MP0001697_abnormal_embryo_size1.72913054
26MP0009697_abnormal_copulation1.71738709
27MP0002396_abnormal_hematopoietic_system1.67568816
28MP0002160_abnormal_reproductive_system1.64818143
29MP0003984_embryonic_growth_retardation1.64445904
30MP0002080_prenatal_lethality1.62560058
31MP0000653_abnormal_sex_gland1.62335350
32MP0008260_abnormal_autophagy1.61448830
33MP0002088_abnormal_embryonic_growth/wei1.59231380
34MP0005408_hypopigmentation1.48838277
35MP0002877_abnormal_melanocyte_morpholog1.48186220
36MP0003698_abnormal_male_reproductive1.47331365
37MP0002085_abnormal_embryonic_tissue1.46766428
38MP0009333_abnormal_splenocyte_physiolog1.42352768
39MP0001661_extended_life_span1.40733546
40MP0005058_abnormal_lysosome_morphology1.40417315
41MP0008789_abnormal_olfactory_epithelium1.40201850
42MP0003567_abnormal_fetal_cardiomyocyte1.40134703
43MP0005171_absent_coat_pigmentation1.38215076
44MP0000358_abnormal_cell_content/1.37517690
45MP0000490_abnormal_crypts_of1.36205843
46MP0002653_abnormal_ependyma_morphology1.34235687
47MP0000313_abnormal_cell_death1.33991613
48MP0000750_abnormal_muscle_regeneration1.32915926
49MP0001529_abnormal_vocalization1.30890423
50MP0010352_gastrointestinal_tract_polyps1.29108200
51MP0002084_abnormal_developmental_patter1.28560030
52MP0005451_abnormal_body_composition1.27788078
53MP0006036_abnormal_mitochondrial_physio1.25771422
54MP0005389_reproductive_system_phenotype1.22539731
55MP0000049_abnormal_middle_ear1.22289515
56MP0010307_abnormal_tumor_latency1.22130421
57MP0003186_abnormal_redox_activity1.18680553
58MP0002736_abnormal_nociception_after1.18265705
59MP0009379_abnormal_foot_pigmentation1.18195759
60MP0005379_endocrine/exocrine_gland_phen1.17806838
61MP0001293_anophthalmia1.17371975
62MP0002086_abnormal_extraembryonic_tissu1.14625147
63MP0005377_hearing/vestibular/ear_phenot1.14224075
64MP0003878_abnormal_ear_physiology1.14224075
65MP0002132_abnormal_respiratory_system1.13918686
66MP0001905_abnormal_dopamine_level1.11637600
67MP0002019_abnormal_tumor_incidence1.11045379
68MP0001346_abnormal_lacrimal_gland1.07899551
69MP0010030_abnormal_orbit_morphology1.07495062
70MP0002161_abnormal_fertility/fecundity1.04035265
71MP0006035_abnormal_mitochondrial_morpho1.03442918
72MP0003221_abnormal_cardiomyocyte_apopto1.03200718
73MP0000678_abnormal_parathyroid_gland1.03145119
74MP0000015_abnormal_ear_pigmentation1.02714688
75MP0001545_abnormal_hematopoietic_system1.02342706
76MP0005397_hematopoietic_system_phenotyp1.02342706
77MP0005623_abnormal_meninges_morphology1.00009525
78MP0003119_abnormal_digestive_system0.97509189
79MP0004233_abnormal_muscle_weight0.96716528
80MP0004858_abnormal_nervous_system0.95487804
81MP0003646_muscle_fatigue0.95374006
82MP0004197_abnormal_fetal_growth/weight/0.95088063
83MP0003283_abnormal_digestive_organ0.93707291
84MP0001727_abnormal_embryo_implantation0.92660927
85MP0001119_abnormal_female_reproductive0.92065832
86MP0005075_abnormal_melanosome_morpholog0.91646991
87MP0005395_other_phenotype0.90512226
88MP0005501_abnormal_skin_physiology0.89786355
89MP0004808_abnormal_hematopoietic_stem0.89300830
90MP0003890_abnormal_embryonic-extraembry0.86205607
91MP0003937_abnormal_limbs/digits/tail_de0.85404105
92MP0001764_abnormal_homeostasis0.85082558
93MP0009672_abnormal_birth_weight0.81888330
94MP0003938_abnormal_ear_development0.80882090
95MP0008995_early_reproductive_senescence0.80520604
96MP0005384_cellular_phenotype0.80448193
97MP0000003_abnormal_adipose_tissue0.80178547
98MP0004185_abnormal_adipocyte_glucose0.79808625
99MP0003806_abnormal_nucleotide_metabolis0.77606591
100MP0002102_abnormal_ear_morphology0.77542044
101MP0005220_abnormal_exocrine_pancreas0.76908449
102MP0005394_taste/olfaction_phenotype0.76857661
103MP0005499_abnormal_olfactory_system0.76857661
104MP0002075_abnormal_coat/hair_pigmentati0.76743750
105MP0001186_pigmentation_phenotype0.76501343
106MP0002837_dystrophic_cardiac_calcinosis0.75925081
107MP0002111_abnormal_tail_morphology0.75791657
108MP0005330_cardiomyopathy0.75588104
109MP0003936_abnormal_reproductive_system0.73477037
110MP0005257_abnormal_intraocular_pressure0.73467665
111MP0000428_abnormal_craniofacial_morphol0.73139123
112MP0003699_abnormal_female_reproductive0.71940543
113MP0003942_abnormal_urinary_system0.69584594
114MP0006292_abnormal_olfactory_placode0.69422271
115MP0004147_increased_porphyrin_level0.67245027
116MP0005332_abnormal_amino_acid0.66007197
117MP0005621_abnormal_cell_physiology0.64606173
118MP0003121_genomic_imprinting0.64363088
119MP0004133_heterotaxia0.63676684
120MP0001919_abnormal_reproductive_system0.63012687
121MP0000537_abnormal_urethra_morphology0.62345056
122MP0002269_muscular_atrophy0.61970893
123MP0002970_abnormal_white_adipose0.61613884
124MP0002177_abnormal_outer_ear0.60312514
125MP0004084_abnormal_cardiac_muscle0.59703973
126MP0001542_abnormal_bone_strength0.58681157
127MP0000627_abnormal_mammary_gland0.57918327
128MP0002163_abnormal_gland_morphology0.56845436
129MP0000538_abnormal_urinary_bladder0.56409960
130MP0002092_abnormal_eye_morphology0.54623681
131MP0002938_white_spotting0.53909711
132MP0000858_altered_metastatic_potential0.53145020
133MP0009703_decreased_birth_body0.49768897
134MP0000703_abnormal_thymus_morphology0.49578960
135MP0009840_abnormal_foam_cell0.48423002
136MP0002127_abnormal_cardiovascular_syste0.46913089
137MP0003136_yellow_coat_color0.46520867
138MP0003763_abnormal_thymus_physiology0.46193341

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.75193506
2Carpal bone hypoplasia (HP:0001498)4.71164796
3Breast hypoplasia (HP:0003187)4.53958947
4Cerebral hypomyelination (HP:0006808)4.29899047
5Rough bone trabeculation (HP:0100670)4.10749962
6Acute encephalopathy (HP:0006846)3.97662027
7Abnormality of cells of the erythroid lineage (HP:0012130)3.97606679
8Abnormal number of erythroid precursors (HP:0012131)3.75180875
9Multiple enchondromatosis (HP:0005701)3.65619495
10Oral leukoplakia (HP:0002745)3.64183026
11Reticulocytopenia (HP:0001896)3.60155275
12Testicular atrophy (HP:0000029)3.54747667
13Progressive macrocephaly (HP:0004481)3.43630944
14Impulsivity (HP:0100710)3.43140466
15Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.40203612
16Progressive muscle weakness (HP:0003323)3.25860066
17Macrocytic anemia (HP:0001972)3.21684090
18Patellar aplasia (HP:0006443)3.20293096
19Aplasia/Hypoplasia of the patella (HP:0006498)3.17132235
20Increased intramyocellular lipid droplets (HP:0012240)3.16416162
21Lactic acidosis (HP:0003128)3.15989717
22Degeneration of anterior horn cells (HP:0002398)3.15463339
23Abnormality of the anterior horn cell (HP:0006802)3.15463339
24Colon cancer (HP:0003003)3.15145294
25Secondary amenorrhea (HP:0000869)3.14407187
26Abnormal protein glycosylation (HP:0012346)3.08745671
27Abnormal glycosylation (HP:0012345)3.08745671
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.08745671
29Abnormal protein N-linked glycosylation (HP:0012347)3.08745671
30Trismus (HP:0000211)3.05691808
31CNS hypomyelination (HP:0003429)3.05530447
32Aplastic anemia (HP:0001915)3.03981733
33Hyperglycinemia (HP:0002154)3.02403100
34Premature ovarian failure (HP:0008209)3.01560754
35Cerebral edema (HP:0002181)2.95492473
36Abnormal trabecular bone morphology (HP:0100671)2.94389570
37Selective tooth agenesis (HP:0001592)2.92160647
38Facial cleft (HP:0002006)2.90966087
39Increased muscle lipid content (HP:0009058)2.90655562
40Exercise intolerance (HP:0003546)2.87808233
41Cutaneous melanoma (HP:0012056)2.77376475
42Microretrognathia (HP:0000308)2.74714568
43Increased hepatocellular lipid droplets (HP:0006565)2.72653984
44Abnormal spermatogenesis (HP:0008669)2.70831474
45Lipid accumulation in hepatocytes (HP:0006561)2.67341554
46Ragged-red muscle fibers (HP:0003200)2.66273910
47Respiratory failure (HP:0002878)2.62228336
48Hypokinesia (HP:0002375)2.60986768
49Neoplasm of the pancreas (HP:0002894)2.60254271
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55451813
51Abnormality of alanine metabolism (HP:0010916)2.55451813
52Hyperalaninemia (HP:0003348)2.55451813
53Broad distal phalanx of finger (HP:0009836)2.54690878
54Absent radius (HP:0003974)2.53302894
55Pallor (HP:0000980)2.51743157
56Absent thumb (HP:0009777)2.51665639
57Abnormality of the umbilical cord (HP:0010881)2.51581837
58Hypoplasia of the capital femoral epiphysis (HP:0003090)2.51212196
59Pancreatic fibrosis (HP:0100732)2.49844159
60Sparse eyelashes (HP:0000653)2.49477309
61Hyperglycinuria (HP:0003108)2.48779620
62Megaloblastic anemia (HP:0001889)2.43837342
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42079299
643-Methylglutaconic aciduria (HP:0003535)2.40804970
65Reduced antithrombin III activity (HP:0001976)2.38803111
66Premature graying of hair (HP:0002216)2.38502929
67Aplasia involving forearm bones (HP:0009822)2.37848511
68Absent forearm bone (HP:0003953)2.37848511
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.35070418
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.35070418
71Horseshoe kidney (HP:0000085)2.34424138
72Renal Fanconi syndrome (HP:0001994)2.33784936
73Postnatal microcephaly (HP:0005484)2.33379169
74Cleft eyelid (HP:0000625)2.32836314
75Meckel diverticulum (HP:0002245)2.31721407
76Supernumerary spleens (HP:0009799)2.29867080
77Abnormality of the preputium (HP:0100587)2.28420007
78Poor head control (HP:0002421)2.24114796
79Hypoplasia of the radius (HP:0002984)2.23780248
80Death in infancy (HP:0001522)2.23681456
81Increased serum lactate (HP:0002151)2.22593979
82Opisthotonus (HP:0002179)2.21704916
83Increased serum pyruvate (HP:0003542)2.21226242
84Abnormality of glycolysis (HP:0004366)2.21226242
85Aplasia/hypoplasia of the uterus (HP:0008684)2.19630499
86Irregular epiphyses (HP:0010582)2.19311345
87Ureteral duplication (HP:0000073)2.18953252
88CNS demyelination (HP:0007305)2.18596304
89Abnormality of the ileum (HP:0001549)2.13665752
90Progressive microcephaly (HP:0000253)2.12164756
91Emotional lability (HP:0000712)2.11872869
92Glossoptosis (HP:0000162)2.10580320
93Bone marrow hypocellularity (HP:0005528)2.10359349
94Cholecystitis (HP:0001082)2.10010903
95Abnormal gallbladder physiology (HP:0012438)2.10010903
96Spastic paraparesis (HP:0002313)2.08047912
97Pancytopenia (HP:0001876)2.06805844
98Leukodystrophy (HP:0002415)2.05307461
99Cellular immunodeficiency (HP:0005374)2.02807693
100Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02576263
101Pancreatic cysts (HP:0001737)2.02200236
102Personality changes (HP:0000751)2.01446899
103Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99799863
104Lethargy (HP:0001254)1.99183343
105Areflexia of lower limbs (HP:0002522)1.99026264
106Acute necrotizing encephalopathy (HP:0006965)1.99001680
107Respiratory difficulties (HP:0002880)1.97253671
108Increased CSF lactate (HP:0002490)1.96866454
109Abnormality of serine family amino acid metabolism (HP:0010894)1.96290240
110Abnormality of glycine metabolism (HP:0010895)1.96290240
111Unsteady gait (HP:0002317)1.95353681
112Abnormality of serum amino acid levels (HP:0003112)1.94951932
113Abnormal number of incisors (HP:0011064)1.93102439
114Absent epiphyses (HP:0010577)1.93050474
115Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93050474
116Hepatic necrosis (HP:0002605)1.92792539
117Male infertility (HP:0003251)1.92234330
118Triphalangeal thumb (HP:0001199)1.91991173
119Type I transferrin isoform profile (HP:0003642)1.91511344
120Squamous cell carcinoma (HP:0002860)1.90402578
121Hepatocellular necrosis (HP:0001404)1.90336550
122Sloping forehead (HP:0000340)1.89200230
123Abnormality of chromosome stability (HP:0003220)1.89110568
124Microvesicular hepatic steatosis (HP:0001414)1.89071898
12511 pairs of ribs (HP:0000878)1.87794331
126Atresia of the external auditory canal (HP:0000413)1.87348865
127Chronic bronchitis (HP:0004469)1.86326351
128Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84028585
129Entropion (HP:0000621)1.83973482
130Mitochondrial inheritance (HP:0001427)1.83656892
131Ependymoma (HP:0002888)1.82045244
132Muscle fiber atrophy (HP:0100295)1.81549790
133Abnormal mitochondria in muscle tissue (HP:0008316)1.80584332
134Nausea (HP:0002018)1.77964981
135Optic disc pallor (HP:0000543)1.77514985
136Abnormal respiratory epithelium morphology (HP:0012253)1.77183835
137Severe visual impairment (HP:0001141)1.75368481
138Nonimmune hydrops fetalis (HP:0001790)1.74324348
139Vertebral compression fractures (HP:0002953)1.74133852
140Retinal dysplasia (HP:0007973)1.73473453
141Hypoplasia of the pons (HP:0012110)1.72687013
142Abnormal umbilical cord blood vessels (HP:0011403)1.72624446
143Single umbilical artery (HP:0001195)1.72624446
144Abnormality of the fetal cardiovascular system (HP:0010948)1.72624446
145Hypoplastic pelvis (HP:0008839)1.71213551
146Severe muscular hypotonia (HP:0006829)1.65978034

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.75187782
2VRK24.81400894
3WEE14.57843115
4EIF2AK13.40284920
5NME23.37299335
6STK163.27132063
7NEK22.69775754
8BRSK22.66827422
9PLK42.58218272
10PBK2.44709553
11SMG12.40504172
12TSSK62.37512166
13SRPK12.34550249
14CDC72.33626847
15EIF2AK32.32128533
16DYRK32.18839196
17ACVR1B2.11032257
18PDK32.09710442
19PDK42.09710442
20TLK11.94276812
21TTK1.93802124
22PLK11.92526126
23LMTK21.90437820
24VRK11.62870738
25CDK71.54530216
26PLK31.54528749
27EPHA21.54394047
28BRSK11.51903896
29TESK21.50296567
30MKNK11.48289565
31CSNK1A1L1.41026934
32CHEK21.40339678
33RPS6KA41.39538030
34MKNK21.37447554
35AURKB1.37339458
36NEK11.28938850
37BCKDK1.28603222
38PDK21.27040111
39ZAK1.24774680
40AURKA1.23288313
41AKT31.21342037
42DAPK11.20886228
43PIM21.19244631
44PRKD31.18831646
45LATS21.16925196
46BRAF1.15161727
47CCNB11.14641880
48RPS6KB21.11360665
49TESK11.10531002
50CSNK1G21.10215608
51STK38L1.09517396
52ATR1.07174770
53EEF2K1.06194306
54NME10.96621641
55MAP3K80.92642775
56MST1R0.88829750
57MAP2K70.88042887
58CHEK10.87426281
59PASK0.87014085
60CDK40.85423611
61ERN10.84789406
62SCYL20.82048554
63PRKCI0.81444981
64PNCK0.81215738
65PAK10.80558950
66PHKG10.76738800
67PHKG20.76738800
68CDK190.76597515
69DYRK20.75919145
70IRAK30.74423808
71MAPKAPK30.74396393
72PAK40.72956888
73MAPK110.71302494
74ARAF0.70734011
75CDK80.68820085
76STK30.68700839
77TRIM280.68492045
78WNK40.67919740
79CSNK2A20.66301650
80TRIB30.64877552
81TAF10.63752614
82EIF2AK20.63652918
83CSNK2A10.63228976
84KDR0.62906832
85PINK10.62553859
86PIM10.60551626
87ICK0.59276948
88MAP3K110.57632382
89CDK20.57057173
90BMX0.55609893
91PTK20.55061072
92ILK0.52078266
93ERBB40.51256971
94RPS6KA50.49601102
95TAOK20.46828769
96ABL20.45900979
97ATM0.44173482
98MAP2K20.44134236
99DAPK30.43294082
100CDK11A0.42851057
101MST40.41968920
102CSNK1G30.41637334
103NUAK10.39290018
104RAF10.38577095
105CDK10.38325888
106CDK140.38038273
107WNK30.37523229
108CDK150.35476972
109CSNK1G10.35274620
110MAP4K20.34839548
111CDK180.34009145
112CSNK1E0.33928927
113MAP3K30.33413417
114MET0.33058298
115STK40.32262921
116AKT20.32051874
117LIMK10.31205884
118CAMK2G0.30885166
119TGFBR10.30609107
120MAP3K90.28377082
121CDK90.26872778
122IRAK20.26213553
123EPHB20.25461235
124GRK10.25421941
125MARK30.24697470
126MAPKAPK50.24243679
127FLT30.23141112
128ALK0.21224367
129STK100.20494408
130IRAK10.20140341
131MELK0.20103195
132MTOR0.19444063
133MAP2K60.12031515
134CSNK1A10.11900423
135CDK30.11871881
136LATS10.11445090
137LRRK20.09666120

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.49357596
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.07588888
3Proteasome_Homo sapiens_hsa030503.88490837
4DNA replication_Homo sapiens_hsa030303.86041979
5Ribosome_Homo sapiens_hsa030103.82116351
6Vitamin B6 metabolism_Homo sapiens_hsa007503.35620924
7Mismatch repair_Homo sapiens_hsa034303.29313402
8RNA transport_Homo sapiens_hsa030133.18710684
9Spliceosome_Homo sapiens_hsa030403.00008892
10Pyrimidine metabolism_Homo sapiens_hsa002402.87304638
11Homologous recombination_Homo sapiens_hsa034402.55584039
12Nucleotide excision repair_Homo sapiens_hsa034202.55460971
13Base excision repair_Homo sapiens_hsa034102.47216008
14Basal transcription factors_Homo sapiens_hsa030222.38358864
15Cell cycle_Homo sapiens_hsa041102.30698433
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05062076
17Folate biosynthesis_Homo sapiens_hsa007901.81437898
18Fanconi anemia pathway_Homo sapiens_hsa034601.81246081
19Purine metabolism_Homo sapiens_hsa002301.77409409
20Fatty acid elongation_Homo sapiens_hsa000621.68310708
21RNA degradation_Homo sapiens_hsa030181.67487872
22One carbon pool by folate_Homo sapiens_hsa006701.64490192
23Sulfur relay system_Homo sapiens_hsa041221.44872220
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38576683
25p53 signaling pathway_Homo sapiens_hsa041151.37874707
26Protein export_Homo sapiens_hsa030601.37455412
27mRNA surveillance pathway_Homo sapiens_hsa030151.35319556
28Pentose phosphate pathway_Homo sapiens_hsa000301.30778534
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27750655
30Sulfur metabolism_Homo sapiens_hsa009201.22515759
31Huntingtons disease_Homo sapiens_hsa050161.22200620
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.21424683
33Non-homologous end-joining_Homo sapiens_hsa034501.19462174
34Epstein-Barr virus infection_Homo sapiens_hsa051691.12848673
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05502600
36Biosynthesis of amino acids_Homo sapiens_hsa012301.00944558
37Parkinsons disease_Homo sapiens_hsa050121.00157960
38Oxidative phosphorylation_Homo sapiens_hsa001900.98347706
39Regulation of autophagy_Homo sapiens_hsa041400.96012156
40Oocyte meiosis_Homo sapiens_hsa041140.95767839
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95103442
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94435934
43Fructose and mannose metabolism_Homo sapiens_hsa000510.89359669
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81193113
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80108674
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.80010549
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76845375
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.76755790
49Carbon metabolism_Homo sapiens_hsa012000.76566708
50Glutathione metabolism_Homo sapiens_hsa004800.75711306
51Vibrio cholerae infection_Homo sapiens_hsa051100.73527285
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71882904
53Selenocompound metabolism_Homo sapiens_hsa004500.71057417
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70765726
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67827217
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66594054
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65284761
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63897711
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.61374736
60Fatty acid metabolism_Homo sapiens_hsa012120.59613697
61Vitamin digestion and absorption_Homo sapiens_hsa049770.59002085
62Metabolic pathways_Homo sapiens_hsa011000.57997092
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57499213
64Antigen processing and presentation_Homo sapiens_hsa046120.55834348
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53659754
66Systemic lupus erythematosus_Homo sapiens_hsa053220.52407171
67Herpes simplex infection_Homo sapiens_hsa051680.50505084
68N-Glycan biosynthesis_Homo sapiens_hsa005100.49982573
69Galactose metabolism_Homo sapiens_hsa000520.49929822
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48062491
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47283283
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46194787
73Arachidonic acid metabolism_Homo sapiens_hsa005900.44191765
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42999974
75Viral carcinogenesis_Homo sapiens_hsa052030.42911454
76Peroxisome_Homo sapiens_hsa041460.42610624
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38921097
78Linoleic acid metabolism_Homo sapiens_hsa005910.38589605
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37826397
80Arginine biosynthesis_Homo sapiens_hsa002200.37350310
81Alzheimers disease_Homo sapiens_hsa050100.37297460
82Arginine and proline metabolism_Homo sapiens_hsa003300.36148014
83Pyruvate metabolism_Homo sapiens_hsa006200.35998766
84Primary immunodeficiency_Homo sapiens_hsa053400.34450986
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.33882609
86HTLV-I infection_Homo sapiens_hsa051660.33692539
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32334534
88Renin-angiotensin system_Homo sapiens_hsa046140.32061610
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30243495
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.29522243
91Thyroid cancer_Homo sapiens_hsa052160.29294210
92Hippo signaling pathway_Homo sapiens_hsa043900.26758948
93Collecting duct acid secretion_Homo sapiens_hsa049660.26355678
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25364957
95Phenylalanine metabolism_Homo sapiens_hsa003600.25173092
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24599346
97Propanoate metabolism_Homo sapiens_hsa006400.24386841
98Hedgehog signaling pathway_Homo sapiens_hsa043400.23925631
99Fatty acid biosynthesis_Homo sapiens_hsa000610.22363190
100Glycerolipid metabolism_Homo sapiens_hsa005610.21313482
101Legionellosis_Homo sapiens_hsa051340.21038912
102Tyrosine metabolism_Homo sapiens_hsa003500.20812145
103Small cell lung cancer_Homo sapiens_hsa052220.20106769
104Fat digestion and absorption_Homo sapiens_hsa049750.19923984
105Lysine degradation_Homo sapiens_hsa003100.18855067
106HIF-1 signaling pathway_Homo sapiens_hsa040660.15180736
107Basal cell carcinoma_Homo sapiens_hsa052170.15053566
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14308180
109Synaptic vesicle cycle_Homo sapiens_hsa047210.12992135
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12109089
111Cardiac muscle contraction_Homo sapiens_hsa042600.11806799
112beta-Alanine metabolism_Homo sapiens_hsa004100.11786786
113AMPK signaling pathway_Homo sapiens_hsa041520.07651814
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07294957
115MicroRNAs in cancer_Homo sapiens_hsa052060.06699856
116TGF-beta signaling pathway_Homo sapiens_hsa043500.05549808
117Bladder cancer_Homo sapiens_hsa052190.05220524
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04385140
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.04218220
120Steroid biosynthesis_Homo sapiens_hsa001000.03844606
121Protein digestion and absorption_Homo sapiens_hsa049740.03359253
122Sphingolipid metabolism_Homo sapiens_hsa006000.03081241
123Circadian rhythm_Homo sapiens_hsa047100.01238454
124Alcoholism_Homo sapiens_hsa050340.00095194
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0052821

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