CD33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.59154489
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.59154489
3modulation by symbiont of host immune response (GO:0052553)6.59154489
4positive regulation by symbiont of host defense response (GO:0052509)6.59154489
5modulation by symbiont of host defense response (GO:0052031)6.59154489
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.59154489
7neutrophil activation involved in immune response (GO:0002283)5.92911963
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.86129853
9cellular extravasation (GO:0045123)5.65674207
10macrophage activation involved in immune response (GO:0002281)5.51580658
11response to peptidoglycan (GO:0032494)5.51357842
12microglial cell activation (GO:0001774)5.24527997
13leukocyte aggregation (GO:0070486)5.09558514
14respiratory burst (GO:0045730)5.04491060
15response to host immune response (GO:0052572)4.97984511
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.97984511
17regulation of interferon-beta biosynthetic process (GO:0045357)4.95850419
18neutrophil mediated immunity (GO:0002446)4.81805947
19neutrophil activation (GO:0042119)4.81325176
20granulocyte activation (GO:0036230)4.60373496
21response to host (GO:0075136)4.56939831
22response to host defenses (GO:0052200)4.56939831
23response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.56939831
24regulation of B cell receptor signaling pathway (GO:0050855)4.52649539
25leukocyte migration involved in inflammatory response (GO:0002523)4.49132193
26detection of bacterium (GO:0016045)4.44072386
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.42816917
28negative regulation of cell killing (GO:0031342)4.42816917
29immunoglobulin mediated immune response (GO:0016064)4.26333922
30production of molecular mediator involved in inflammatory response (GO:0002532)4.25787534
31superoxide anion generation (GO:0042554)4.25392717
32positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.20334589
33regulation of mast cell degranulation (GO:0043304)4.16761485
34myeloid cell activation involved in immune response (GO:0002275)4.03599611
35macrophage activation (GO:0042116)4.01772142
36positive regulation of mast cell activation (GO:0033005)4.00177926
37neutrophil chemotaxis (GO:0030593)3.99354261
38regulation of mast cell activation involved in immune response (GO:0033006)3.92989926
39positive regulation of cellular amide metabolic process (GO:0034250)3.92881286
40regulation of hypersensitivity (GO:0002883)3.91249868
41regulation of mast cell activation (GO:0033003)3.90025492
42antigen processing and presentation of endogenous antigen (GO:0019883)3.89274938
43neutrophil migration (GO:1990266)3.88000247
44negative regulation of granulocyte differentiation (GO:0030853)3.86767377
45regulation of gamma-delta T cell activation (GO:0046643)3.85834349
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.81838579
47positive regulation of mast cell degranulation (GO:0043306)3.81838579
48response to muramyl dipeptide (GO:0032495)3.81579690
49regulation of leukocyte degranulation (GO:0043300)3.81380674
50regulation of myeloid leukocyte mediated immunity (GO:0002886)3.80294081
51response to fungus (GO:0009620)3.74463634
52hydrogen peroxide biosynthetic process (GO:0050665)3.68493586
53positive regulation of B cell differentiation (GO:0045579)3.65486506
54interferon-gamma-mediated signaling pathway (GO:0060333)3.64262792
55positive regulation of gamma-delta T cell activation (GO:0046645)3.64223239
56positive regulation of interferon-alpha production (GO:0032727)3.63225299
57detection of biotic stimulus (GO:0009595)3.60526485
58myeloid leukocyte mediated immunity (GO:0002444)3.58386238
59granulocyte chemotaxis (GO:0071621)3.56590865
60regulation of tolerance induction (GO:0002643)3.56311453
61mast cell activation (GO:0045576)3.53824619
62granulocyte migration (GO:0097530)3.51147496
63negative regulation of interleukin-12 production (GO:0032695)3.50182172
64lipopolysaccharide-mediated signaling pathway (GO:0031663)3.45302320
65regulation of interferon-alpha production (GO:0032647)3.42678518
66positive regulation of antigen processing and presentation (GO:0002579)3.39545569
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39501424
68G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.37187141
69regulation of T cell tolerance induction (GO:0002664)3.35305201
70negative regulation of interleukin-17 production (GO:0032700)3.33655126
71positive regulation of regulated secretory pathway (GO:1903307)3.31668690
72reactive oxygen species biosynthetic process (GO:1903409)3.30747368
73leukotriene metabolic process (GO:0006691)3.30026357
74negative regulation of T cell mediated immunity (GO:0002710)3.29948356
75regulation of B cell differentiation (GO:0045577)3.29798921
76regulation of gamma-delta T cell differentiation (GO:0045586)3.23721061
77macrophage differentiation (GO:0030225)3.22909305
78regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.20040837
79positive regulation of chemokine secretion (GO:0090197)3.17887203
80defense response to fungus (GO:0050832)3.16212715
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16123345
82myeloid leukocyte activation (GO:0002274)3.13079032
83detection of other organism (GO:0098543)3.12025130
84regulation of regulated secretory pathway (GO:1903305)3.12009548
85leukocyte mediated cytotoxicity (GO:0001909)3.11545537
86positive regulation of leukocyte degranulation (GO:0043302)3.10762007
87antigen processing and presentation via MHC class Ib (GO:0002475)3.10296467
88I-kappaB phosphorylation (GO:0007252)3.08422806
89negative regulation of lymphocyte mediated immunity (GO:0002707)3.07621369
90leukocyte cell-cell adhesion (GO:0007159)3.05751610
91pinocytosis (GO:0006907)3.05244653
92negative regulation of erythrocyte differentiation (GO:0045647)3.04076867
93positive thymic T cell selection (GO:0045059)3.03283297
94detection of molecule of bacterial origin (GO:0032490)3.03191099
95response to protozoan (GO:0001562)3.02536037
96positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.01971379
97negative regulation of interleukin-6 production (GO:0032715)3.00756628
98regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97976761
99B cell mediated immunity (GO:0019724)2.97491606
100B cell receptor signaling pathway (GO:0050853)2.96201556
101negative regulation of mast cell activation (GO:0033004)2.95303116
102T-helper 1 type immune response (GO:0042088)2.93511257
103positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.92857091
104myeloid leukocyte migration (GO:0097529)2.90441842
105phagosome maturation (GO:0090382)2.88060867
106regulation of interleukin-8 biosynthetic process (GO:0045414)2.87730860
107antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86522262
108positive regulation of toll-like receptor signaling pathway (GO:0034123)2.85171263
109cytokine secretion (GO:0050663)2.83951413
110positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.83287924
111positive regulation of interleukin-17 production (GO:0032740)2.83176047
112leukocyte chemotaxis (GO:0030595)2.82608859
113germinal center formation (GO:0002467)2.82545826
114regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82215382
115cellular response to interferon-gamma (GO:0071346)2.81638057
116T cell migration (GO:0072678)2.81377843
117regulation of antigen processing and presentation (GO:0002577)2.81342922
118defense response to protozoan (GO:0042832)2.80923104
119negative regulation of leukocyte mediated immunity (GO:0002704)2.80539123
120positive regulation of interleukin-1 beta secretion (GO:0050718)2.79071432
121negative regulation of cytokine production involved in immune response (GO:0002719)2.78404989
122cell wall macromolecule catabolic process (GO:0016998)2.78146767
123leukocyte degranulation (GO:0043299)2.77239918
124positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.77222826
125negative regulation of interleukin-1 beta production (GO:0032691)2.76905270
126positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.76105892
127negative regulation of interleukin-1 production (GO:0032692)2.73759235
128dendritic cell migration (GO:0036336)2.73588050
129lipoxygenase pathway (GO:0019372)2.72604948
130detection of external biotic stimulus (GO:0098581)2.72458469
131positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.72314381
132positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.72268558
133disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.72067085
134killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.72067085
135phagocytosis, engulfment (GO:0006911)2.70623039
136cellular defense response (GO:0006968)2.70006610
137sequestering of metal ion (GO:0051238)2.69668700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.59233734
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.15775326
3* IRF8_27001747_Chip-Seq_BMDM_Mouse4.71286256
4* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.66826514
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.48447864
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.15477488
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.89397382
8* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.78845343
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.61162499
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57574639
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.38035272
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.15758767
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.12757958
14SCL_19346495_ChIP-Seq_HPC-7_Human2.99790628
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82463919
16* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.80288786
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73591404
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.72881949
19* SPI1_23547873_ChIP-Seq_NB4_Human2.66075811
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54207110
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41526152
22* SPI1_23127762_ChIP-Seq_K562_Human2.37398372
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32035272
24VDR_24763502_ChIP-Seq_THP-1_Human2.24504078
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15732479
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15162870
27VDR_21846776_ChIP-Seq_THP-1_Human2.14202010
28RUNX_20019798_ChIP-Seq_JUKART_Human2.11950238
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.07781226
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07047742
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04939865
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.04104586
33PU_27001747_Chip-Seq_BMDM_Mouse2.00927514
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00247058
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95249103
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93229613
37VDR_24787735_ChIP-Seq_THP-1_Human1.89340618
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84346003
39MYB_26560356_Chip-Seq_TH2_Human1.80987746
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.77065926
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76817222
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74664550
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65508720
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64983828
45MAF_26560356_Chip-Seq_TH1_Human1.59941068
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57030777
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54765429
48MYB_26560356_Chip-Seq_TH1_Human1.53868958
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51651866
50TCF7_22412390_ChIP-Seq_EML_Mouse1.51373406
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51125500
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.50156634
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45104038
54UTX_26944678_Chip-Seq_JUKART_Human1.41695551
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.34093117
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33995508
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31144287
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29225406
59CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26274966
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26189275
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.25251948
62GATA3_27048872_Chip-Seq_THYMUS_Human1.24835815
63GATA3_26560356_Chip-Seq_TH2_Human1.24627678
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23074850
65* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20852557
66BCL6_27268052_Chip-Seq_Bcells_Human1.20463889
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19632603
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19028551
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16788374
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13792803
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13453504
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12833129
73MYC_22102868_ChIP-Seq_BL_Human1.08899049
74GATA2_19941826_ChIP-Seq_K562_Human1.06079386
75STAT1_20625510_ChIP-Seq_HELA_Human1.05604854
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05227165
77* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05049070
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04592453
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.02469215
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01419061
81PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99893954
82GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98722860
83BCOR_27268052_Chip-Seq_Bcells_Human0.98559964
84CIITA_25753668_ChIP-Seq_RAJI_Human0.98411131
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97526902
86P300_27268052_Chip-Seq_Bcells_Human0.94562808
87SMAD_19615063_ChIP-ChIP_OVARY_Human0.94368245
88KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93088744
89* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92065883
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91044204
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90790615
92RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87337014
93GATA1_19941826_ChIP-Seq_K562_Human0.86020547
94SPI1_20517297_ChIP-Seq_HL60_Human0.84952301
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83555875
96FOXM1_23109430_ChIP-Seq_U2OS_Human0.82880741
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80269938
98NCOR1_26117541_ChIP-Seq_K562_Human0.79610165
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79498241
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79407549
101ELK3_25401928_ChIP-Seq_HUVEC_Human0.78665996
102VDR_23849224_ChIP-Seq_CD4+_Human0.78175297
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76721623
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.76015027
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75960623
106MAF_26560356_Chip-Seq_TH2_Human0.73714270
107KDM2B_26808549_Chip-Seq_DND41_Human0.72404510
108SMRT_27268052_Chip-Seq_Bcells_Human0.71434664
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.70026231
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69934856
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65431339
112EGR1_19032775_ChIP-ChIP_M12_Human0.64345594
113GATA1_22025678_ChIP-Seq_K562_Human0.62945851
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61846331
115ETS1_22383799_ChIP-Seq_G1ME_Mouse0.59948468
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.58350131
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.56382954
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.54119099
119TP53_16413492_ChIP-PET_HCT116_Human0.54060675
120TFEB_21752829_ChIP-Seq_HELA_Human0.52741079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.07762381
2MP0001835_abnormal_antigen_presentation3.95153411
3MP0003303_peritoneal_inflammation3.81687570
4MP0002419_abnormal_innate_immunity3.54696500
5MP0005058_abnormal_lysosome_morphology3.45312625
6MP0000569_abnormal_digit_pigmentation3.04367568
7MP0009785_altered_susceptibility_to3.01995748
8MP0002148_abnormal_hypersensitivity_rea2.97538587
9MP0005464_abnormal_platelet_physiology2.94591528
10MP0006082_CNS_inflammation2.89298450
11MP0005000_abnormal_immune_tolerance2.81050535
12MP0003172_abnormal_lysosome_physiology2.73631985
13MP0009278_abnormal_bone_marrow2.72786990
14MP0005025_abnormal_response_to2.71649016
15MP0003183_abnormal_peptide_metabolism2.67319184
16MP0002452_abnormal_antigen_presenting2.59878901
17MP0003191_abnormal_cellular_cholesterol2.55762601
18MP0005671_abnormal_response_to2.49436546
19MP0001800_abnormal_humoral_immune2.42094438
20MP0002723_abnormal_immune_serum2.39744934
21MP0003724_increased_susceptibility_to2.29547564
22MP0005387_immune_system_phenotype2.28229008
23MP0001790_abnormal_immune_system2.28229008
24MP0001533_abnormal_skeleton_physiology2.27666920
25MP0001819_abnormal_immune_cell2.26922370
26MP0002420_abnormal_adaptive_immunity2.25548643
27MP0000343_altered_response_to2.14148037
28MP0000685_abnormal_immune_system2.13579289
29MP0001853_heart_inflammation2.02675905
30MP0003806_abnormal_nucleotide_metabolis2.02396785
31MP0002405_respiratory_system_inflammati2.02064998
32MP0003075_altered_response_to1.94742980
33MP0003300_gastrointestinal_ulcer1.87744346
34* MP0001845_abnormal_inflammatory_respons1.82852742
35MP0005174_abnormal_tail_pigmentation1.75701011
36MP0002396_abnormal_hematopoietic_system1.74708961
37MP0004510_myositis1.73677392
38MP0001545_abnormal_hematopoietic_system1.69385965
39MP0005397_hematopoietic_system_phenotyp1.69385965
40MP0001851_eye_inflammation1.65427787
41MP0000716_abnormal_immune_system1.64341455
42MP0004947_skin_inflammation1.62008892
43MP0002398_abnormal_bone_marrow1.57645571
44MP0009764_decreased_sensitivity_to1.57523072
45* MP0008469_abnormal_protein_level1.52497065
46MP0003448_altered_tumor_morphology1.48476587
47MP0010155_abnormal_intestine_physiology1.45302895
48MP0005167_abnormal_blood-brain_barrier1.43010900
49MP0003828_pulmonary_edema1.42903374
50MP0005310_abnormal_salivary_gland1.40815228
51MP0004808_abnormal_hematopoietic_stem1.40209568
52MP0000689_abnormal_spleen_morphology1.39740563
53MP0000465_gastrointestinal_hemorrhage1.37316894
54MP0000015_abnormal_ear_pigmentation1.37009396
55MP0002277_abnormal_respiratory_mucosa1.33802485
56MP0009840_abnormal_foam_cell1.32700734
57* MP0002429_abnormal_blood_cell1.32579480
58MP0003690_abnormal_glial_cell1.31680034
59MP0005075_abnormal_melanosome_morpholog1.29841093
60MP0005166_decreased_susceptibility_to1.29643959
61MP0000858_altered_metastatic_potential1.29565826
62MP0002722_abnormal_immune_system1.26211635
63MP0002933_joint_inflammation1.24822529
64MP0002132_abnormal_respiratory_system1.22698177
65MP0002998_abnormal_bone_remodeling1.21830224
66MP0009333_abnormal_splenocyte_physiolog1.17737121
67MP0001986_abnormal_taste_sensitivity1.17693098
68MP0004883_abnormal_blood_vessel1.15356670
69MP0001873_stomach_inflammation1.12723987
70MP0002006_tumorigenesis1.12548480
71MP0003566_abnormal_cell_adhesion1.11587207
72MP0002166_altered_tumor_susceptibility1.09020522
73MP0005390_skeleton_phenotype1.05081342
74MP0005451_abnormal_body_composition1.04247281
75MP0000604_amyloidosis1.03293349
76MP0002928_abnormal_bile_duct1.01570927
77MP0005076_abnormal_cell_differentiation0.98560333
78MP0005164_abnormal_response_to0.97177834
79MP0010307_abnormal_tumor_latency0.95275810
80MP0008004_abnormal_stomach_pH0.89098271
81MP0000371_diluted_coat_color0.87280002
82MP0000249_abnormal_blood_vessel0.81962193
83MP0003279_aneurysm0.81872796
84MP0005023_abnormal_wound_healing0.81689233
85MP0009765_abnormal_xenobiotic_induced0.80931027
86MP0009763_increased_sensitivity_to0.80787222
87MP0003453_abnormal_keratinocyte_physiol0.80518846
88MP0003656_abnormal_erythrocyte_physiolo0.78612104
89MP0006036_abnormal_mitochondrial_physio0.75905138
90MP0003195_calcinosis0.74783717
91MP0000767_abnormal_smooth_muscle0.73090417
92MP0000920_abnormal_myelination0.72241867
93MP0003646_muscle_fatigue0.69829408
94MP0000490_abnormal_crypts_of0.69613541
95MP0003795_abnormal_bone_structure0.69425510
96MP0000703_abnormal_thymus_morphology0.69213387
97MP0002254_reproductive_system_inflammat0.66825057
98MP0005535_abnormal_body_temperature0.66204765
99MP0003045_fibrosis0.63235714
100MP0003638_abnormal_response/metabolism_0.62775076
101MP0002009_preneoplasia0.61404282
102MP0004381_abnormal_hair_follicle0.60858120
103MP0001663_abnormal_digestive_system0.60645806
104MP0004782_abnormal_surfactant_physiolog0.60058291
105MP0005084_abnormal_gallbladder_morpholo0.59641660
106MP0008260_abnormal_autophagy0.58706487
107* MP0005319_abnormal_enzyme/_coenzyme0.58146272
108MP0004147_increased_porphyrin_level0.57820838
109MP0001958_emphysema0.57653488
110MP0008873_increased_physiological_sensi0.56530753
111MP0005647_abnormal_sex_gland0.52677498
112MP0002693_abnormal_pancreas_physiology0.52119260
113MP0003866_abnormal_defecation0.51476063
114MP0002019_abnormal_tumor_incidence0.50886870
115MP0003763_abnormal_thymus_physiology0.50804314
116MP0002095_abnormal_skin_pigmentation0.50482402
117MP0005334_abnormal_fat_pad0.49185827
118MP0003091_abnormal_cell_migration0.44996195
119MP0001191_abnormal_skin_condition0.44181685
120MP0002136_abnormal_kidney_physiology0.42276313

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.50570158
2Eczematoid dermatitis (HP:0000976)8.03837467
3Recurrent bacterial skin infections (HP:0005406)7.75435007
4Recurrent gram-negative bacterial infections (HP:0005420)6.65776046
5Systemic lupus erythematosus (HP:0002725)6.04437794
6Abnormality of macrophages (HP:0004311)5.14865852
7Recurrent skin infections (HP:0001581)4.69643712
8Mediastinal lymphadenopathy (HP:0100721)4.51730930
9Obstructive lung disease (HP:0006536)4.49524205
10Chronic obstructive pulmonary disease (HP:0006510)4.49524205
11Gingivitis (HP:0000230)4.46074718
12Glomerulonephritis (HP:0000099)4.42097055
13Vacuolated lymphocytes (HP:0001922)4.22638820
14Increased cerebral lipofuscin (HP:0011813)4.21385148
15Recurrent fungal infections (HP:0002841)4.18699989
16Myositis (HP:0100614)4.04283015
17Increased neuronal autofluorescent lipopigment (HP:0002074)4.03093568
18Abnormality of glycolipid metabolism (HP:0010969)3.74037533
19Abnormality of liposaccharide metabolism (HP:0010968)3.74037533
20Abnormality of glycosphingolipid metabolism (HP:0004343)3.74037533
21Stomatitis (HP:0010280)3.65901071
22Elevated erythrocyte sedimentation rate (HP:0003565)3.51436966
23Dysostosis multiplex (HP:0000943)3.50118587
24Encephalitis (HP:0002383)3.47949734
25Gastrointestinal infarctions (HP:0005244)3.33269517
26Disinhibition (HP:0000734)3.25614740
27Cellulitis (HP:0100658)3.23778499
28Recurrent cutaneous fungal infections (HP:0011370)3.18116494
29Chronic mucocutaneous candidiasis (HP:0002728)3.18116494
30Axonal loss (HP:0003447)3.14675707
31Periodontitis (HP:0000704)3.11726425
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.07310887
33Orchitis (HP:0100796)3.05256534
34Panhypogammaglobulinemia (HP:0003139)3.00593908
35Agnosia (HP:0010524)2.99266490
36Chest pain (HP:0100749)2.95629558
37Keratoconjunctivitis sicca (HP:0001097)2.94963641
38Meningitis (HP:0001287)2.92397113
39Hematochezia (HP:0002573)2.92176894
40Spontaneous hematomas (HP:0007420)2.85175186
41Urticaria (HP:0001025)2.84338398
42Keratoconjunctivitis (HP:0001096)2.82458696
43Pustule (HP:0200039)2.80792444
44Interstitial pulmonary disease (HP:0006530)2.75120069
45Retrobulbar optic neuritis (HP:0100654)2.75069413
46Optic neuritis (HP:0100653)2.75069413
47Osteomyelitis (HP:0002754)2.75021577
48Recurrent viral infections (HP:0004429)2.74588102
49Mucopolysacchariduria (HP:0008155)2.73747309
50Urinary glycosaminoglycan excretion (HP:0003541)2.73747309
51Nephritis (HP:0000123)2.73422620
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72217215
53Abnormality of polysaccharide metabolism (HP:0011012)2.72217215
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72217215
55Episodic fever (HP:0001954)2.66979753
56Prostate neoplasm (HP:0100787)2.61966857
57Abnormality of the prostate (HP:0008775)2.58315679
58Recurrent pneumonia (HP:0006532)2.56686333
59Vasculitis (HP:0002633)2.56380574
60Complement deficiency (HP:0004431)2.51919495
61Abnormality of complement system (HP:0005339)2.51428979
62Increased serum ferritin (HP:0003281)2.50004411
63Abnormality of T cell physiology (HP:0011840)2.48490190
64Abnormality of T cells (HP:0002843)2.46474286
65Leukocytosis (HP:0001974)2.45568687
66Hepatosplenomegaly (HP:0001433)2.43270045
67Colitis (HP:0002583)2.42098679
68Autoimmune thrombocytopenia (HP:0001973)2.41977814
69Anorexia (HP:0002039)2.40957188
70Inflammation of the large intestine (HP:0002037)2.39504179
71Prolonged bleeding time (HP:0003010)2.39346917
72Agammaglobulinemia (HP:0004432)2.38970694
73Thrombocytosis (HP:0001894)2.38148491
74Increased IgE level (HP:0003212)2.37666116
75Abnormality of the pleura (HP:0002103)2.37571108
76Pulmonary embolism (HP:0002204)2.36691107
77Abnormality of iron homeostasis (HP:0011031)2.35746823
78Purpura (HP:0000979)2.34179378
79Osteolytic defects of the hand bones (HP:0009699)2.33910224
80Osteolytic defects of the phalanges of the hand (HP:0009771)2.33910224
81Gangrene (HP:0100758)2.33878088
82Basal ganglia calcification (HP:0002135)2.30161995
83Thick nail (HP:0001805)2.27995180
84Abnormality of T cell number (HP:0011839)2.26812251
85Arterial tortuosity (HP:0005116)2.26410983
86T lymphocytopenia (HP:0005403)2.26241729
87IgM deficiency (HP:0002850)2.25338401
88Cheilitis (HP:0100825)2.22353690
89Vertigo (HP:0002321)2.21835160
90Polyneuropathy (HP:0001271)2.21796544
91Gastrointestinal inflammation (HP:0004386)2.20666615
92Thoracic kyphosis (HP:0002942)2.20591057
93Amaurosis fugax (HP:0100576)2.20389551
94Thickened calvaria (HP:0002684)2.20224873
95Gingival bleeding (HP:0000225)2.20081598
96Epistaxis (HP:0000421)2.19449841
97Eosinophilia (HP:0001880)2.17564021
98Petechiae (HP:0000967)2.13990589
99Abnormality of transition element cation homeostasis (HP:0011030)2.13836187
100Arterial thrombosis (HP:0004420)2.11850541
101Hemoptysis (HP:0002105)2.11697408
102Cerebral aneurysm (HP:0004944)2.09792817
1033-Methylglutaconic aciduria (HP:0003535)2.07273890
104Pathologic fracture (HP:0002756)2.06758924
105Skin rash (HP:0000988)2.06705160
106Hypochromic anemia (HP:0001931)2.05710798
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05679507
108Recurrent lower respiratory tract infections (HP:0002783)2.04496003
109Thyroiditis (HP:0100646)2.03144624
110Hypochromic microcytic anemia (HP:0004840)2.02875061
111Upper motor neuron abnormality (HP:0002127)2.02308522
112Impaired platelet aggregation (HP:0003540)2.01349203
113Abnormal platelet function (HP:0011869)2.01349203
114Pulmonary infiltrates (HP:0002113)2.00180769
115Increased IgM level (HP:0003496)1.98031903
116Loss of speech (HP:0002371)1.97112263
117Abnormality of the heme biosynthetic pathway (HP:0010472)1.94150383
118Progressive visual loss (HP:0000529)1.93790391
119Fatigue (HP:0012378)1.93642655
120Abnormal delayed hypersensitivity skin test (HP:0002963)1.93623686
121Spondylolisthesis (HP:0003302)1.93085458
122Chronic diarrhea (HP:0002028)1.91329001
123Mutism (HP:0002300)1.91005509
124Vascular tortuosity (HP:0004948)1.90742637
125Glomerulopathy (HP:0100820)1.90734261
126Global brain atrophy (HP:0002283)1.90502645
127Retinal atrophy (HP:0001105)1.90309412
128Sepsis (HP:0100806)1.89726913
129Bone pain (HP:0002653)1.88968921
130Myocardial infarction (HP:0001658)1.88588315
131Urethral obstruction (HP:0000796)1.85032270
132Abnormality of B cell number (HP:0010975)1.84393275
133Polycythemia (HP:0001901)1.82291294
134J-shaped sella turcica (HP:0002680)1.81976529
135Granulocytopenia (HP:0001913)1.81932996
136Thrombophlebitis (HP:0004418)1.81865622
137Amyloidosis (HP:0011034)1.81080086
138Abnormality of the thoracic spine (HP:0100711)1.79034861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.45333443
2IRAK44.21591196
3TGFBR24.16415019
4BLK4.14314289
5MAP4K12.80569831
6CSF1R2.62072178
7IRAK32.51317862
8MAP3K142.41237938
9TYK22.27572754
10TBK12.20482197
11KIT2.17190041
12FES2.13775310
13EPHB12.11443455
14TXK2.08934478
15GRK72.08381244
16TEC1.92455975
17BTK1.88525099
18CAMK1D1.82643557
19CSK1.82538651
20HCK1.82346279
21STK101.74471476
22ZAP701.69424275
23TAOK31.66544236
24CLK11.59826717
25ERN11.59394357
26CDK191.59253293
27FGR1.51330399
28MAP2K31.47259544
29SYK1.42259974
30JAK11.37840611
31ITK1.37633482
32IKBKB1.37191042
33SIK21.34355095
34CAMK1G1.33894308
35TRPM71.28771085
36IKBKE1.25509506
37MAP3K131.24505844
38ADRBK21.22761287
39PAK41.18666529
40* LYN1.16832801
41JAK31.09359965
42MATK1.04002711
43YES11.03644669
44* LCK1.00712611
45PRPF4B0.98692458
46JAK20.98403866
47MARK30.98181595
48PTK60.96426476
49FLT30.95396198
50PKN20.92193754
51TAOK10.90125042
52MAPK150.89083124
53NEK90.88195444
54DAPK20.88170710
55TTN0.85234451
56PIM10.77536030
57ACVR1B0.74919988
58EIF2AK20.74509328
59IRAK10.74384306
60MAP3K100.70054695
61GRK60.68882810
62RPS6KA40.68818962
63PIK3CG0.68134013
64TLK10.66641142
65MOS0.64181784
66PRKCQ0.63630077
67CDK120.63597189
68MAPKAPK20.62971992
69CHUK0.61300783
70PRKCD0.60326288
71PDK10.59963729
72CAMKK20.59129284
73TRIB30.59104099
74SIK30.56002128
75MAP2K60.55442285
76FRK0.54840909
77TAOK20.52915883
78ABL10.52859056
79STK40.52034464
80MARK20.50277347
81PDPK10.50219310
82NME20.49078345
83PRKG20.48896353
84LRRK20.47810875
85ERBB30.46790051
86CDK60.46788571
87MAP3K30.45792581
88MAPK120.45399827
89INSRR0.44944651
90HIPK20.44575193
91TESK20.44339086
92MAPK40.44215652
93RPS6KA20.43989125
94KDR0.43408295
95PTK2B0.42782638
96FYN0.40999303
97MAP3K60.40965618
98MAPK70.40482055
99CAMKK10.39958746
100RPS6KA60.38468046
101MAP3K110.38170113
102BCKDK0.38168187
103MAP3K20.37265374
104ALK0.36946293
105DYRK1B0.36854930
106DMPK0.36718113
107OXSR10.36646095
108BMPR20.35892987
109PRKAA20.32812173
110PRKD20.32603935
111* EGFR0.32581795
112RPS6KC10.32475991
113RPS6KL10.32475991
114IRAK20.31878519
115MAP3K50.31533045
116MAP2K20.30824719
117CAMK40.30771524
118MAP4K20.30552406
119MAP3K90.30527961
120IGF1R0.30297934
121STK110.30114322
122CDK40.28539496
123TGFBR10.26381345
124STK240.26058770
125SGK30.25851336
126MAPK110.24444922
127TNK20.22781450
128EEF2K0.22257093
129STK30.21313803
130PRKCH0.20860936
131MAP3K10.19991329

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.14550907
2Leishmaniasis_Homo sapiens_hsa051403.53859554
3Osteoclast differentiation_Homo sapiens_hsa043802.87655464
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.62978944
5Other glycan degradation_Homo sapiens_hsa005112.59463539
6Pertussis_Homo sapiens_hsa051332.40777887
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.36226798
8Tuberculosis_Homo sapiens_hsa051522.25598415
9Lysosome_Homo sapiens_hsa041422.21521731
10Legionellosis_Homo sapiens_hsa051342.21085982
11B cell receptor signaling pathway_Homo sapiens_hsa046622.06714182
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.00357437
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.94528328
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.89894967
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77926759
16Phagosome_Homo sapiens_hsa041451.76657203
17Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.75087001
18Malaria_Homo sapiens_hsa051441.75080444
19Asthma_Homo sapiens_hsa053101.64658364
20Chemokine signaling pathway_Homo sapiens_hsa040621.61717161
21Rheumatoid arthritis_Homo sapiens_hsa053231.60027571
22* Hematopoietic cell lineage_Homo sapiens_hsa046401.58857879
23Measles_Homo sapiens_hsa051621.58846856
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57915813
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57398731
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55029629
27Graft-versus-host disease_Homo sapiens_hsa053321.53724399
28Salmonella infection_Homo sapiens_hsa051321.52743805
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50326956
30Toxoplasmosis_Homo sapiens_hsa051451.48307872
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.46083228
32Influenza A_Homo sapiens_hsa051641.39946919
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38372851
34TNF signaling pathway_Homo sapiens_hsa046681.37948910
35Allograft rejection_Homo sapiens_hsa053301.35420648
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34287311
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.33761272
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25104499
39Shigellosis_Homo sapiens_hsa051311.15803719
40Antigen processing and presentation_Homo sapiens_hsa046121.12532571
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.12021487
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12007479
43Apoptosis_Homo sapiens_hsa042101.11318903
44African trypanosomiasis_Homo sapiens_hsa051431.11300282
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06994458
46Platelet activation_Homo sapiens_hsa046111.06333986
47Hepatitis B_Homo sapiens_hsa051611.05486990
48Herpes simplex infection_Homo sapiens_hsa051681.02775292
49Pancreatic cancer_Homo sapiens_hsa052120.99607304
50Chronic myeloid leukemia_Homo sapiens_hsa052200.99065810
51Complement and coagulation cascades_Homo sapiens_hsa046100.97480925
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97291049
53Amoebiasis_Homo sapiens_hsa051460.92585317
54Acute myeloid leukemia_Homo sapiens_hsa052210.92428907
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89220776
56Type I diabetes mellitus_Homo sapiens_hsa049400.88865684
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.84858923
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82066529
59T cell receptor signaling pathway_Homo sapiens_hsa046600.81862594
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79344067
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73730929
62Caffeine metabolism_Homo sapiens_hsa002320.72376425
63Viral myocarditis_Homo sapiens_hsa054160.70901703
64Hepatitis C_Homo sapiens_hsa051600.68947547
65Primary immunodeficiency_Homo sapiens_hsa053400.68495974
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66563630
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.64080951
68Systemic lupus erythematosus_Homo sapiens_hsa053220.62847381
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61739688
70Oxidative phosphorylation_Homo sapiens_hsa001900.61482933
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61292788
72Prion diseases_Homo sapiens_hsa050200.60571135
73Endocytosis_Homo sapiens_hsa041440.60138430
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59993632
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59454606
76Type II diabetes mellitus_Homo sapiens_hsa049300.54153785
77VEGF signaling pathway_Homo sapiens_hsa043700.51558670
78ABC transporters_Homo sapiens_hsa020100.51252481
79Non-small cell lung cancer_Homo sapiens_hsa052230.48908356
80Regulation of autophagy_Homo sapiens_hsa041400.46685749
81Arachidonic acid metabolism_Homo sapiens_hsa005900.45579223
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45098543
83Ribosome_Homo sapiens_hsa030100.45009737
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42947574
85HIF-1 signaling pathway_Homo sapiens_hsa040660.42811011
86Colorectal cancer_Homo sapiens_hsa052100.41691621
87Sphingolipid metabolism_Homo sapiens_hsa006000.41313971
88Prolactin signaling pathway_Homo sapiens_hsa049170.39010042
89Epstein-Barr virus infection_Homo sapiens_hsa051690.38036815
90Parkinsons disease_Homo sapiens_hsa050120.37726003
91Notch signaling pathway_Homo sapiens_hsa043300.36507781
92Renal cell carcinoma_Homo sapiens_hsa052110.36018408
93Insulin resistance_Homo sapiens_hsa049310.35835513
94Rap1 signaling pathway_Homo sapiens_hsa040150.35657852
95Ether lipid metabolism_Homo sapiens_hsa005650.35515080
96Inositol phosphate metabolism_Homo sapiens_hsa005620.34802818
97Collecting duct acid secretion_Homo sapiens_hsa049660.34690799
98FoxO signaling pathway_Homo sapiens_hsa040680.34634068
99MAPK signaling pathway_Homo sapiens_hsa040100.33209221
100Autoimmune thyroid disease_Homo sapiens_hsa053200.32791160
101Linoleic acid metabolism_Homo sapiens_hsa005910.31987564
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31318440
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.30332876
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.29989040
105Dorso-ventral axis formation_Homo sapiens_hsa043200.29759879
106Viral carcinogenesis_Homo sapiens_hsa052030.29647247
107Proteoglycans in cancer_Homo sapiens_hsa052050.29565312
108Small cell lung cancer_Homo sapiens_hsa052220.27075954
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26838361
110HTLV-I infection_Homo sapiens_hsa051660.26081007
111Glioma_Homo sapiens_hsa052140.25858354
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23960210
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.22702074
114Estrogen signaling pathway_Homo sapiens_hsa049150.20546049
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19563889
116Alzheimers disease_Homo sapiens_hsa050100.18309939
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17069469
118Renin-angiotensin system_Homo sapiens_hsa046140.14376618
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13807270
120Olfactory transduction_Homo sapiens_hsa047400.12194339
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.12099480
122Bladder cancer_Homo sapiens_hsa052190.11007060
123Nitrogen metabolism_Homo sapiens_hsa009100.08204434
124GnRH signaling pathway_Homo sapiens_hsa049120.06110847

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