CD34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.37253691
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.78646000
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.78646000
4platelet dense granule organization (GO:0060155)5.76341782
5aggressive behavior (GO:0002118)5.69100127
6lymphoid progenitor cell differentiation (GO:0002320)5.62653704
7definitive hemopoiesis (GO:0060216)5.57243884
8negative regulation of granulocyte differentiation (GO:0030853)5.16673608
9blood vessel maturation (GO:0001955)5.14992119
10vascular endothelial growth factor signaling pathway (GO:0038084)4.99845530
11viral transcription (GO:0019083)4.79229396
12DNA deamination (GO:0045006)4.70879157
13antigen processing and presentation of endogenous antigen (GO:0019883)4.58167535
14translational termination (GO:0006415)4.56177581
15thrombin receptor signaling pathway (GO:0070493)4.51008061
16lymph vessel development (GO:0001945)4.50765697
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.50735341
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.37467514
19antigen processing and presentation via MHC class Ib (GO:0002475)4.19002584
20Peyers patch development (GO:0048541)4.09433940
21mucosal-associated lymphoid tissue development (GO:0048537)4.09433940
22cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.07927600
23valine metabolic process (GO:0006573)4.06965727
24regulation of female receptivity (GO:0045924)4.06779332
25megakaryocyte development (GO:0035855)3.99433466
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.97020953
27translational elongation (GO:0006414)3.93936131
28secretory granule organization (GO:0033363)3.92070315
29cotranslational protein targeting to membrane (GO:0006613)3.86521850
30female mating behavior (GO:0060180)3.82799921
31protein targeting to ER (GO:0045047)3.82425917
32negative regulation of erythrocyte differentiation (GO:0045647)3.81500560
33seminiferous tubule development (GO:0072520)3.81239690
34cellular response to exogenous dsRNA (GO:0071360)3.80516708
35positive regulation of B cell differentiation (GO:0045579)3.72876887
36hyperosmotic salinity response (GO:0042538)3.69033048
37telomere maintenance via semi-conservative replication (GO:0032201)3.66163821
38establishment of protein localization to endoplasmic reticulum (GO:0072599)3.65504134
39response to interferon-beta (GO:0035456)3.65190245
40histamine transport (GO:0051608)3.64492051
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.63748556
42protein localization to endoplasmic reticulum (GO:0070972)3.58414913
43negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.57571859
44autophagic vacuole fusion (GO:0000046)3.57265326
45negative regulation of blood vessel endothelial cell migration (GO:0043537)3.53817681
46fucose catabolic process (GO:0019317)3.53483074
47L-fucose metabolic process (GO:0042354)3.53483074
48L-fucose catabolic process (GO:0042355)3.53483074
49negative regulation of phagocytosis (GO:0050765)3.53246755
50viral life cycle (GO:0019058)3.51497914
51histamine secretion (GO:0001821)3.49452405
52ribosomal small subunit biogenesis (GO:0042274)3.46818655
53regulation of B cell differentiation (GO:0045577)3.46589760
54cellular hyperosmotic response (GO:0071474)3.46525267
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.45403135
56negative regulation of B cell apoptotic process (GO:0002903)3.43203354
57regulation of granulocyte differentiation (GO:0030852)3.42585776
58negative regulation of macrophage differentiation (GO:0045650)3.42561773
59response to interferon-alpha (GO:0035455)3.41932141
60regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.40622685
61mast cell activation (GO:0045576)3.40164886
62* endothelium development (GO:0003158)3.37956246
63DNA strand elongation involved in DNA replication (GO:0006271)3.32386665
64cellular protein complex disassembly (GO:0043624)3.28370917
65endothelial tube morphogenesis (GO:0061154)3.23188963
66morphogenesis of an endothelium (GO:0003159)3.23188963
67tyrosine phosphorylation of STAT protein (GO:0007260)3.23011039
68DNA strand elongation (GO:0022616)3.20595682
69negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.20552836
70maturation of SSU-rRNA (GO:0030490)3.19725979
71positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)3.17872596
72positive thymic T cell selection (GO:0045059)3.16642342
73mature B cell differentiation involved in immune response (GO:0002313)3.15821048
74regulation of gamma-delta T cell differentiation (GO:0045586)3.15763620
75macrophage differentiation (GO:0030225)3.11675505
76telomere maintenance via recombination (GO:0000722)3.09561401
77arginine catabolic process (GO:0006527)3.08012342
78regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.07822840
79regulation of B cell apoptotic process (GO:0002902)3.03924342
80negative regulation of smooth muscle cell proliferation (GO:0048662)3.03881694
81positive regulation of lipid kinase activity (GO:0090218)3.03043318
82positive regulation of gamma-delta T cell activation (GO:0046645)3.01914888
83DNA unwinding involved in DNA replication (GO:0006268)3.01502364
84response to vitamin E (GO:0033197)3.00935421
85embryonic hemopoiesis (GO:0035162)3.00503254
86venous blood vessel morphogenesis (GO:0048845)3.00348598
87necroptotic process (GO:0070266)2.99391227
88purine deoxyribonucleotide catabolic process (GO:0009155)2.98567987
89cellular response to interferon-beta (GO:0035458)2.95788028
90T cell homeostasis (GO:0043029)2.95230833
91triglyceride catabolic process (GO:0019433)2.94265717
92* positive regulation of vasculogenesis (GO:2001214)2.94122009
93translational initiation (GO:0006413)2.94051584
94phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.92503961
95protein complex disassembly (GO:0043241)2.90579853
96mast cell degranulation (GO:0043303)2.89060134
97mast cell activation involved in immune response (GO:0002279)2.89060134
98pinocytosis (GO:0006907)2.88670857
99positive regulation of lamellipodium assembly (GO:0010592)2.85304990
100* angiogenesis involved in wound healing (GO:0060055)2.84934436
101regulation of erythrocyte differentiation (GO:0045646)2.84204356
102branched-chain amino acid metabolic process (GO:0009081)2.83634411
103positive regulation of T cell mediated cytotoxicity (GO:0001916)2.83225664
104positive regulation of glomerulus development (GO:0090193)2.82646816
105sprouting angiogenesis (GO:0002040)2.81903844
106regulation of urine volume (GO:0035809)2.81516594
107protein kinase C signaling (GO:0070528)2.80267196
108positive regulation of respiratory burst (GO:0060267)2.78784209
109regulation of T cell mediated cytotoxicity (GO:0001914)2.77726404
110regulation of necroptotic process (GO:0060544)2.76529123
111mitotic recombination (GO:0006312)2.76171329
112regulation of B cell receptor signaling pathway (GO:0050855)2.76104968
113interkinetic nuclear migration (GO:0022027)2.75281076
114organelle membrane fusion (GO:0090174)2.74725066
115basement membrane organization (GO:0071711)2.73834603
116Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73381894
117heparin biosynthetic process (GO:0030210)2.72645460
118heparin metabolic process (GO:0030202)2.72645460
119negative regulation of nitric-oxide synthase activity (GO:0051001)2.71710077
120leukocyte homeostasis (GO:0001776)2.69865006
121response to protozoan (GO:0001562)2.69757380
122positive regulation of antigen processing and presentation (GO:0002579)2.69369311
123positive regulation of urine volume (GO:0035810)2.69245623
124regulation of antigen processing and presentation (GO:0002577)2.68874190
125regulation of respiratory burst (GO:0060263)2.68756514
126purine-containing compound salvage (GO:0043101)2.68425361
127positive regulation of granulocyte differentiation (GO:0030854)2.68339504
128macromolecular complex disassembly (GO:0032984)2.67212079
129deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.66674833
130response to UV-B (GO:0010224)2.66527808
131phagocytosis, engulfment (GO:0006911)2.65968693
132lymph node development (GO:0048535)2.65872078
133protein targeting to membrane (GO:0006612)2.64873422
134nuclear-transcribed mRNA catabolic process (GO:0000956)2.64241394
135telomere maintenance via telomere lengthening (GO:0010833)2.64098518
136endosome to melanosome transport (GO:0035646)2.63182290
137endosome to pigment granule transport (GO:0043485)2.63182290
138DNA replication initiation (GO:0006270)2.63162270
139growth hormone receptor signaling pathway (GO:0060396)2.63004576
140hyperosmotic response (GO:0006972)2.62845217
141phospholipid scrambling (GO:0017121)2.61211620
142cGMP biosynthetic process (GO:0006182)2.61124392
143regulation of sarcomere organization (GO:0060297)2.60765441
144regulation of necrotic cell death (GO:0010939)2.60732792
145defense response to protozoan (GO:0042832)2.59981883
146immunoglobulin mediated immune response (GO:0016064)2.59964478
147ovulation from ovarian follicle (GO:0001542)2.59568619
148regulation of penile erection (GO:0060405)2.59506427
149deoxyribonucleotide catabolic process (GO:0009264)2.59030299
150negative regulation of stress fiber assembly (GO:0051497)2.58230379
151regulation of skeletal muscle contraction (GO:0014819)2.56782650
152purine nucleotide salvage (GO:0032261)2.56144363
153dosage compensation (GO:0007549)2.53615802
154nitric oxide mediated signal transduction (GO:0007263)2.53326139
1552-oxoglutarate metabolic process (GO:0006103)2.52808465
156regulation of germinal center formation (GO:0002634)2.52305106
157pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.52050791
158negative regulation of actin filament bundle assembly (GO:0032232)2.51239402
159deoxyribose phosphate catabolic process (GO:0046386)2.50199945
160phosphatidylglycerol biosynthetic process (GO:0006655)2.49803856
161lymphangiogenesis (GO:0001946)2.48745726
162positive regulation of prostaglandin secretion (GO:0032308)2.48404971
163negative regulation of T-helper cell differentiation (GO:0045623)2.47747476
164negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.47747476
165* regulation of vasculogenesis (GO:2001212)2.47613839
166regulation of T-helper 1 cell differentiation (GO:0045625)2.46800456
167positive regulation of digestive system process (GO:0060456)2.45114513
168short-chain fatty acid metabolic process (GO:0046459)2.44114024
169establishment of endothelial barrier (GO:0061028)2.44073745
170mature B cell differentiation (GO:0002335)2.41963927
171regulation of histone phosphorylation (GO:0033127)2.40993037
172negative regulation of endothelial cell migration (GO:0010596)2.40880712
173neutral lipid catabolic process (GO:0046461)2.38186457
174acylglycerol catabolic process (GO:0046464)2.38186457
175grooming behavior (GO:0007625)2.36256234
176maternal behavior (GO:0042711)2.35678481
177B cell mediated immunity (GO:0019724)2.34789248
178regulation of endothelial cell differentiation (GO:0045601)2.34048071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.87861674
2SCL_19346495_ChIP-Seq_HPC-7_Human5.35133915
3GATA1_22025678_ChIP-Seq_K562_Human4.05627729
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.94327264
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.65306837
6* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.51134369
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.43709004
8MYB_21317192_ChIP-Seq_ERMYB_Mouse3.17380289
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.94736592
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.92005839
11* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.91115190
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.83433087
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80811204
14* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.71663758
15VDR_21846776_ChIP-Seq_THP-1_Human2.62946143
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.60579502
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.60017073
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.53850283
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.49416626
20GATA2_21666600_ChIP-Seq_HMVEC_Human2.48181393
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.47588633
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45776097
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42409128
24SPI1_23547873_ChIP-Seq_NB4_Human2.27153936
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.23822960
26* LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.20555027
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19715513
28VDR_24763502_ChIP-Seq_THP-1_Human2.19606708
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19124988
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07226616
31* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.05677839
32MYC_22102868_ChIP-Seq_BL_Human2.04903479
33GATA1_19941826_ChIP-Seq_K562_Human2.01055030
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98485854
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.93824936
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91882489
37* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.91259103
38* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.91002609
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.89826661
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.88926492
41* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82695962
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80843729
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80005570
44MYB_26560356_Chip-Seq_TH2_Human1.79820624
45MAF_26560356_Chip-Seq_TH1_Human1.79253412
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76639585
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74842621
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74357310
49GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.73983223
50* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73482587
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.73307567
52* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.72669242
53* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71684906
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.70269029
55TCF7_22412390_ChIP-Seq_EML_Mouse1.69600311
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64424711
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.62461804
58SPI1_23127762_ChIP-Seq_K562_Human1.55552187
59MYB_26560356_Chip-Seq_TH1_Human1.54818321
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.51362292
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50471592
62UTX_26944678_Chip-Seq_JUKART_Human1.49499953
63* ELF1_20517297_ChIP-Seq_JURKAT_Human1.45189697
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43482283
65* RUNX_20019798_ChIP-Seq_JUKART_Human1.43455436
66* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39067881
67BCL6_27268052_Chip-Seq_Bcells_Human1.38523804
68CIITA_25753668_ChIP-Seq_RAJI_Human1.35910638
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35186346
70* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33696309
71SPI1_20517297_ChIP-Seq_HL60_Human1.30240368
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27352384
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27194010
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26955455
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26851285
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25843368
77KDM2B_26808549_Chip-Seq_DND41_Human1.24425317
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24137029
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23380029
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22435079
81FOXP3_21729870_ChIP-Seq_TREG_Human1.21234466
82CTCF_26484167_Chip-Seq_Bcells_Mouse1.21092890
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20298095
84VDR_24787735_ChIP-Seq_THP-1_Human1.17178681
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16543950
86* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13046802
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12447238
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12197679
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11065844
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10639965
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09997919
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.09937395
93VDR_23849224_ChIP-Seq_CD4+_Human1.07033569
94FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06345863
95P68_20966046_ChIP-Seq_HELA_Human1.04709541
96CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04382004
97P300_27268052_Chip-Seq_Bcells_Human1.02817102
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02746958
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02132363
100* GATA2_19941826_ChIP-Seq_K562_Human1.01617431
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.01223375
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01188895
103RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00158635
104YY1_22570637_ChIP-Seq_MALME-3M_Human0.99378829
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97229179
106* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96351964
107PU_27001747_Chip-Seq_BMDM_Mouse0.96027119
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.95727941
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.95727941
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95515012
111* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95165896
112BCOR_27268052_Chip-Seq_Bcells_Human0.95097321
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94629257
114XRN2_22483619_ChIP-Seq_HELA_Human0.94346091
115MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93794554
116SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92543856
117LXR_22292898_ChIP-Seq_THP-1_Human0.91978076
118E2F1_21310950_ChIP-Seq_MCF-7_Human0.90970176
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89613006
120ZNF263_19887448_ChIP-Seq_K562_Human0.89124046
121STAT1_20625510_ChIP-Seq_HELA_Human0.88299732
122* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87750410
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87570452
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86552142
125GATA3_27048872_Chip-Seq_THYMUS_Human0.86325288
126E2F1_20622854_ChIP-Seq_HELA_Human0.85415410
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84790354
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82874502
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82385196
130ZNF274_21170338_ChIP-Seq_K562_Hela0.82290479
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82142537
132E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82080278
133* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81746260
134SMC1_22415368_ChIP-Seq_MEFs_Mouse0.81736089
135TTF2_22483619_ChIP-Seq_HELA_Human0.80955600
136EST1_17652178_ChIP-ChIP_JURKAT_Human0.80909794
137MAF_26560356_Chip-Seq_TH2_Human0.79760682
138PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78803039
139GATA3_26560356_Chip-Seq_TH2_Human0.78071455
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77708354
141ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77147921
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76949081
143* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76771123
144ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75747617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system5.36230069
2MP0010368_abnormal_lymphatic_system4.50277095
3MP0001879_abnormal_lymphatic_vessel3.98573071
4MP0005670_abnormal_white_adipose3.38460466
5MP0006054_spinal_hemorrhage3.20979762
6MP0004808_abnormal_hematopoietic_stem2.84278060
7MP0004147_increased_porphyrin_level2.81767276
8MP0003724_increased_susceptibility_to2.78305360
9MP0003828_pulmonary_edema2.65486893
10MP0000013_abnormal_adipose_tissue2.58987143
11MP0000465_gastrointestinal_hemorrhage2.47095591
12MP0005167_abnormal_blood-brain_barrier2.46333606
13MP0001835_abnormal_antigen_presentation2.37596201
14MP0005397_hematopoietic_system_phenotyp2.34493660
15MP0001545_abnormal_hematopoietic_system2.34493660
16MP0004272_abnormal_basement_membrane2.34186921
17MP0009785_altered_susceptibility_to2.24885337
18MP0009379_abnormal_foot_pigmentation2.23179721
19MP0005174_abnormal_tail_pigmentation2.04001549
20MP0000343_altered_response_to1.97737669
21MP0005084_abnormal_gallbladder_morpholo1.92328116
22MP0002166_altered_tumor_susceptibility1.90251132
23MP0005464_abnormal_platelet_physiology1.89146046
24MP0008007_abnormal_cellular_replicative1.84413716
25MP0005666_abnormal_adipose_tissue1.83993288
26MP0002138_abnormal_hepatobiliary_system1.83382438
27MP0005375_adipose_tissue_phenotype1.77677517
28MP0004084_abnormal_cardiac_muscle1.73785022
29MP0000685_abnormal_immune_system1.71847787
30MP0009278_abnormal_bone_marrow1.71509821
31MP0009697_abnormal_copulation1.69608278
32MP0000003_abnormal_adipose_tissue1.68485098
33MP0005025_abnormal_response_to1.64285330
34MP0008438_abnormal_cutaneous_collagen1.61904605
35MP0002148_abnormal_hypersensitivity_rea1.61121942
36MP0005409_darkened_coat_color1.56650700
37MP0004130_abnormal_muscle_cell1.51910900
38MP0001188_hyperpigmentation1.47872732
39MP0003279_aneurysm1.46446779
40MP0003763_abnormal_thymus_physiology1.46104635
41MP0002420_abnormal_adaptive_immunity1.45140310
42MP0005075_abnormal_melanosome_morpholog1.44616787
43MP0000751_myopathy1.44374227
44MP0002419_abnormal_innate_immunity1.44356998
45* MP0002398_abnormal_bone_marrow1.42888786
46MP0000490_abnormal_crypts_of1.42557747
47MP0001819_abnormal_immune_cell1.42077118
48MP0001853_heart_inflammation1.40646675
49MP0005671_abnormal_response_to1.39811876
50MP0002006_tumorigenesis1.38765179
51MP0010155_abnormal_intestine_physiology1.34752663
52MP0003567_abnormal_fetal_cardiomyocyte1.33346484
53MP0005503_abnormal_tendon_morphology1.33238776
54MP0005535_abnormal_body_temperature1.32873805
55MP0006036_abnormal_mitochondrial_physio1.32427572
56MP0002452_abnormal_antigen_presenting1.31754350
57MP0002095_abnormal_skin_pigmentation1.31442997
58MP0003806_abnormal_nucleotide_metabolis1.28777403
59MP0003191_abnormal_cellular_cholesterol1.28392940
60MP0002723_abnormal_immune_serum1.27682145
61MP0000230_abnormal_systemic_arterial1.26876674
62MP0005646_abnormal_pituitary_gland1.24199250
63MP0000249_abnormal_blood_vessel1.21086754
64MP0003943_abnormal_hepatobiliary_system1.19484296
65MP0001800_abnormal_humoral_immune1.19386836
66MP0000767_abnormal_smooth_muscle1.18836306
67MP0001873_stomach_inflammation1.18740489
68MP0003300_gastrointestinal_ulcer1.18096127
69* MP0002429_abnormal_blood_cell1.17814363
70MP0005000_abnormal_immune_tolerance1.16590076
71MP0002971_abnormal_brown_adipose1.16250297
72* MP0000716_abnormal_immune_system1.14699212
73MP0001958_emphysema1.13305103
74MP0004145_abnormal_muscle_electrophysio1.13130897
75MP0002722_abnormal_immune_system1.12418035
76MP0002127_abnormal_cardiovascular_syste1.12255512
77MP0004782_abnormal_surfactant_physiolog1.12120983
78MP0003075_altered_response_to1.11767566
79MP0005330_cardiomyopathy1.11667884
80* MP0000689_abnormal_spleen_morphology1.09775551
81MP0004215_abnormal_myocardial_fiber1.07843326
82MP0004484_altered_response_of1.05900666
83MP0000015_abnormal_ear_pigmentation1.03394040
84MP0003436_decreased_susceptibility_to1.01351813
85MP0005165_increased_susceptibility_to1.00482272
86MP0002405_respiratory_system_inflammati0.98325134
87MP0005385_cardiovascular_system_phenoty0.97733166
88MP0001544_abnormal_cardiovascular_syste0.97733166
89MP0009333_abnormal_splenocyte_physiolog0.96840195
90MP0009764_decreased_sensitivity_to0.96771960
91MP0006138_congestive_heart_failure0.95794041
92MP0006276_abnormal_autonomic_nervous0.95659554
93MP0005275_abnormal_skin_tensile0.94965896
94MP0003866_abnormal_defecation0.94876370
95MP0010094_abnormal_chromosome_stability0.94053790
96MP0003566_abnormal_cell_adhesion0.93470988
97MP0010630_abnormal_cardiac_muscle0.93198032
98MP0004036_abnormal_muscle_relaxation0.92317912
99MP0002876_abnormal_thyroid_physiology0.91076006
100MP0002332_abnormal_exercise_endurance0.89636017
101MP0003646_muscle_fatigue0.89578633
102MP0009115_abnormal_fat_cell0.89542232
103MP0005595_abnormal_vascular_smooth0.89535869
104MP0000703_abnormal_thymus_morphology0.88584244
105MP0005220_abnormal_exocrine_pancreas0.87742663
106MP0005645_abnormal_hypothalamus_physiol0.87271221
107MP0002933_joint_inflammation0.85225851
108MP0002128_abnormal_blood_circulation0.84785788
109MP0001845_abnormal_inflammatory_respons0.83202156
110MP0000681_abnormal_thyroid_gland0.82038440
111MP0004087_abnormal_muscle_fiber0.81599703
112MP0005334_abnormal_fat_pad0.80453620
113MP0001614_abnormal_blood_vessel0.79146302
114MP0005620_abnormal_muscle_contractility0.78803146
115MP0008469_abnormal_protein_level0.78624217
116MP0002106_abnormal_muscle_physiology0.78516165
117MP0001790_abnormal_immune_system0.78038785
118MP0005387_immune_system_phenotype0.78038785
119MP0002108_abnormal_muscle_morphology0.77384390
120MP0002060_abnormal_skin_morphology0.76990911
121MP0002925_abnormal_cardiovascular_devel0.76760700
122MP0001851_eye_inflammation0.76386148
123MP0003959_abnormal_lean_body0.75407613
124MP0001986_abnormal_taste_sensitivity0.74650189
125MP0002972_abnormal_cardiac_muscle0.74288345
126MP0005390_skeleton_phenotype0.73905465
127MP0005369_muscle_phenotype0.73670932
128MP0000749_muscle_degeneration0.72558394
129MP0002132_abnormal_respiratory_system0.71712411
130MP0003221_abnormal_cardiomyocyte_apopto0.71627585
131* MP0002019_abnormal_tumor_incidence0.70034798
132MP0004085_abnormal_heartbeat0.70033539
133MP0001764_abnormal_homeostasis0.69476119
134MP0003303_peritoneal_inflammation0.69224537
135MP0002877_abnormal_melanocyte_morpholog0.68576232
136MP0001533_abnormal_skeleton_physiology0.68293286
137MP0008775_abnormal_heart_ventricle0.67938566
138MP0003638_abnormal_response/metabolism_0.65959889

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.08363046
2Thrombocytosis (HP:0001894)5.04866214
3Chronic otitis media (HP:0000389)4.64377193
4Myositis (HP:0100614)4.62262719
5Acute lymphatic leukemia (HP:0006721)4.29070938
6Abnormality of cells of the erythroid lineage (HP:0012130)4.17008638
7Abnormal number of erythroid precursors (HP:0012131)4.03773783
8Agammaglobulinemia (HP:0004432)3.91347834
9Muscle fiber splitting (HP:0003555)3.86081353
10Hematochezia (HP:0002573)3.85057175
11Aplastic anemia (HP:0001915)3.83468812
12IgM deficiency (HP:0002850)3.78516634
13Abnormality of the nasal mucosa (HP:0000433)3.70420050
14Acute myeloid leukemia (HP:0004808)3.66010118
15Spontaneous hematomas (HP:0007420)3.59205782
16Reticulocytopenia (HP:0001896)3.58336229
17Exercise-induced myalgia (HP:0003738)3.31030722
18Prolonged bleeding time (HP:0003010)3.19304739
19Reduced antithrombin III activity (HP:0001976)3.17792753
20Distal arthrogryposis (HP:0005684)3.02706032
21Nemaline bodies (HP:0003798)2.97690488
22Centrally nucleated skeletal muscle fibers (HP:0003687)2.97387535
23Protrusio acetabuli (HP:0003179)2.97237155
24Oligomenorrhea (HP:0000876)2.91362710
25Cerebral palsy (HP:0100021)2.90785208
26Abnormal platelet function (HP:0011869)2.86028192
27Impaired platelet aggregation (HP:0003540)2.86028192
28Increased muscle lipid content (HP:0009058)2.83391494
29Autoimmune hemolytic anemia (HP:0001890)2.81468442
30Ankle contracture (HP:0006466)2.72451290
31Recurrent abscess formation (HP:0002722)2.71999578
32Interstitial pulmonary disease (HP:0006530)2.71879767
33Muscle fiber inclusion bodies (HP:0100299)2.69491514
34Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.69443673
35Metaphyseal dysplasia (HP:0100255)2.68588887
36Type I transferrin isoform profile (HP:0003642)2.67134281
37Abnormality of the heme biosynthetic pathway (HP:0010472)2.63383025
38Stomach cancer (HP:0012126)2.63132784
39Petechiae (HP:0000967)2.62459532
40Hyporeflexia of lower limbs (HP:0002600)2.60542686
41Increased variability in muscle fiber diameter (HP:0003557)2.57384778
42Sudden death (HP:0001699)2.56019522
43Erythema (HP:0010783)2.54823079
44Reduced subcutaneous adipose tissue (HP:0003758)2.54030898
45Rhabdomyolysis (HP:0003201)2.53659553
46Abnormality of T cell physiology (HP:0011840)2.52943628
47Recurrent bronchitis (HP:0002837)2.45348443
48Growth hormone excess (HP:0000845)2.44386965
49Mesangial abnormality (HP:0001966)2.44031966
50Dicarboxylic aciduria (HP:0003215)2.38368517
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38368517
52Neck muscle weakness (HP:0000467)2.38075712
53Inflammation of the large intestine (HP:0002037)2.35515700
54Abnormal protein glycosylation (HP:0012346)2.35364471
55Abnormal glycosylation (HP:0012345)2.35364471
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35364471
57Abnormal protein N-linked glycosylation (HP:0012347)2.35364471
58Panhypogammaglobulinemia (HP:0003139)2.33266496
59Delayed CNS myelination (HP:0002188)2.33224488
60Atrioventricular block (HP:0001678)2.33205787
61Increased intramyocellular lipid droplets (HP:0012240)2.32160556
62Granulocytopenia (HP:0001913)2.31290381
63Polygenic inheritance (HP:0010982)2.30940009
64Gastrointestinal inflammation (HP:0004386)2.29732066
65Muscle stiffness (HP:0003552)2.29071309
66Hypoproteinemia (HP:0003075)2.29051133
67Broad metatarsal (HP:0001783)2.28557115
68Polycythemia (HP:0001901)2.26409709
69Microcytic anemia (HP:0001935)2.26304442
70Cervical subluxation (HP:0003308)2.24950834
71Seborrheic dermatitis (HP:0001051)2.24564829
72Myoglobinuria (HP:0002913)2.23001365
73Areflexia of lower limbs (HP:0002522)2.19555275
74Epistaxis (HP:0000421)2.19271199
75Pallor (HP:0000980)2.18727640
76Orchitis (HP:0100796)2.17866844
77Flat cornea (HP:0007720)2.17646453
78Colitis (HP:0002583)2.15920411
79Nasal polyposis (HP:0100582)2.14485141
80Cellulitis (HP:0100658)2.13457609
81Vertigo (HP:0002321)2.12378024
82Abnormality of the hepatic vasculature (HP:0006707)2.11995624
83Round ear (HP:0100830)2.11728133
84Abnormality of the periventricular white matter (HP:0002518)2.11420139
85Asymmetric septal hypertrophy (HP:0001670)2.11263944
86Increased connective tissue (HP:0009025)2.08683285
87Congenital, generalized hypertrichosis (HP:0004540)2.07297737
88Subaortic stenosis (HP:0001682)2.06997826
89Abnormality of the left ventricular outflow tract (HP:0011103)2.06997826
90Papilledema (HP:0001085)2.06809764
91Heart block (HP:0012722)2.06244717
92Autoimmune thrombocytopenia (HP:0001973)2.05687113
93Recurrent bacterial skin infections (HP:0005406)2.03857323
94Hypergammaglobulinemia (HP:0010702)2.03615883
95Abnormal delayed hypersensitivity skin test (HP:0002963)2.03476770
96Acanthosis nigricans (HP:0000956)2.03330553
97B lymphocytopenia (HP:0010976)2.02715480
98Abnormality of B cell number (HP:0010975)2.02715480
99Type 2 muscle fiber atrophy (HP:0003554)2.01737237
100Albinism (HP:0001022)2.01319734
101Muscle fiber atrophy (HP:0100295)2.00088736
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99949624
103Abnormality of alanine metabolism (HP:0010916)1.99949624
104Hyperalaninemia (HP:0003348)1.99949624
105Cerebral aneurysm (HP:0004944)1.98835304
106Recurrent fungal infections (HP:0002841)1.97839829
107Rimmed vacuoles (HP:0003805)1.97702232
108Poikiloderma (HP:0001029)1.96962789
109Ventricular tachycardia (HP:0004756)1.96162866
110Porencephaly (HP:0002132)1.95448726
111Lymphedema (HP:0001004)1.94493822
112Bulbar palsy (HP:0001283)1.93193170
113Increased IgE level (HP:0003212)1.92536671
114Chest pain (HP:0100749)1.92226879
115Lipoatrophy (HP:0100578)1.92174225
116Periorbital edema (HP:0100539)1.91839179
117Stomatitis (HP:0010280)1.91639144
118Hypothermia (HP:0002045)1.90991672
119Bicuspid aortic valve (HP:0001647)1.90877857
120Nonimmune hydrops fetalis (HP:0001790)1.89575975
121Abnormality of the peritoneum (HP:0002585)1.88994506
122EMG: myopathic abnormalities (HP:0003458)1.88924017
123Facial diplegia (HP:0001349)1.88737112
124Type 1 muscle fiber predominance (HP:0003803)1.88720120
125Broad face (HP:0000283)1.88687662
126Insulin-resistant diabetes mellitus (HP:0000831)1.88511973
127Macrocytic anemia (HP:0001972)1.88097746
128Abnormal atrioventricular conduction (HP:0005150)1.86463340
129Chronic obstructive pulmonary disease (HP:0006510)1.86058861
130Obstructive lung disease (HP:0006536)1.86058861
131Spinal cord lesions (HP:0100561)1.85566197
132Syringomyelia (HP:0003396)1.85566197
133Abnormality of skeletal muscle fiber size (HP:0012084)1.85447737
134Supraventricular arrhythmia (HP:0005115)1.85420276
135Hypertriglyceridemia (HP:0002155)1.85329625
136Hypertensive crisis (HP:0100735)1.84224206
137Ragged-red muscle fibers (HP:0003200)1.82548604
138Joint stiffness (HP:0001387)1.82487954
139Meningitis (HP:0001287)1.82310447
140Abnormality of the columella (HP:0009929)1.82004275
141J-shaped sella turcica (HP:0002680)1.80264466
142Weak cry (HP:0001612)1.79776163
143Recurrent viral infections (HP:0004429)1.79462892
144Abnormality of the prostate (HP:0008775)1.79438255
145Facial edema (HP:0000282)1.79279454
146Malignant hyperthermia (HP:0002047)1.78794524
147Primary atrial arrhythmia (HP:0001692)1.78727865
148Difficulty running (HP:0009046)1.78292219
149Pigmentary retinal degeneration (HP:0001146)1.78070607
150Myelodysplasia (HP:0002863)1.77145148
151Atrial fibrillation (HP:0005110)1.77079780
152Severe visual impairment (HP:0001141)1.76239252
153High pitched voice (HP:0001620)1.76170275
154Adactyly (HP:0009776)1.75311508
155Large hands (HP:0001176)1.73643488
156Arterial thrombosis (HP:0004420)1.71651952
157Hemoptysis (HP:0002105)1.71593066
158Entropion (HP:0000621)1.71080892
159Portal hypertension (HP:0001409)1.70608266
160Fatigue (HP:0012378)1.69854097
161Bruising susceptibility (HP:0000978)1.69160646
162Lymphoma (HP:0002665)1.67479348
163Myotonia (HP:0002486)1.67264208
164Lymphangioma (HP:0100764)1.66446853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.38137122
2FLT35.33519329
3KIT4.69324813
4KDR3.52114473
5TGFBR13.25507617
6TGFBR22.94538203
7TEC2.79107015
8CSF1R2.58554751
9ACVR1B2.26649984
10TNIK2.25260626
11WEE12.06750371
12MAP4K12.06620666
13MAP2K32.04614672
14BTK1.96418142
15PIM21.82320644
16EEF2K1.75858793
17NME21.75796217
18BRSK21.71420450
19INSRR1.52917334
20MAPKAPK31.51154058
21MAP4K21.50826355
22MAP3K61.48203002
23MYLK1.46236237
24STK161.44644909
25OBSCN1.36234789
26FES1.30090287
27VRK21.29062498
28BCKDK1.28595470
29IRAK41.27903106
30FER1.27617181
31MAP3K121.26920332
32SCYL21.25708362
33TNK21.23655455
34CDK191.23191691
35RIPK11.21844502
36PINK11.20197358
37ZAP701.19323215
38VRK11.15631024
39TBK11.15070431
40NLK1.13629574
41MATK1.11420381
42CDK81.09212444
43PKN21.07416366
44MAP3K131.04741056
45RPS6KB21.03986541
46ADRBK21.03124004
47CAMKK20.98710147
48DAPK20.98528469
49LRRK20.96893199
50MAPKAPK50.96718237
51CCNB10.95608047
52BMPR1B0.94822016
53ITK0.92046406
54ERN10.89687614
55PAK40.89521094
56SYK0.83961020
57JAK30.79691763
58GRK60.79673948
59PRKG20.77740088
60MAPK70.72252140
61TSSK60.71669359
62DYRK30.70139135
63TESK20.68680790
64MAPK120.67466314
65MKNK10.66114894
66CDK90.64354421
67MAP3K10.63510261
68TTN0.63331993
69MUSK0.63244249
70LYN0.61750676
71TYK20.59209625
72MAPK40.59070787
73TRPM70.58340859
74CAMK10.58199810
75MAP3K30.57837674
76MAP3K110.57609299
77PRKCQ0.56963073
78MAPK30.56419556
79PDK20.55702811
80DAPK10.54416030
81PTK2B0.54167480
82IKBKE0.51242563
83RPS6KA40.50618741
84GRK50.49170250
85MAP3K140.48982568
86PRKD10.47865920
87CDK70.47065088
88ADRBK10.46413652
89* LCK0.46201876
90ILK0.46042118
91CLK10.45482994
92PRKD20.45406719
93BRSK10.45070945
94HCK0.44495233
95ABL20.44009052
96PIM10.43496435
97PAK20.43175417
98GRK10.41023950
99RPS6KL10.41014584
100RPS6KC10.41014584
101CSK0.38716151
102ZAK0.37253471
103DYRK1B0.37074389
104TXK0.36720292
105PIK3CA0.36203969
106HIPK20.34974977
107MAP2K60.34080454
108DAPK30.33116546
109PIK3CG0.32914836
110TRIB30.32825481
111MAP2K20.32298308
112IKBKB0.31829371
113ATR0.29865803
114MAPK110.28932170
115CDK60.28626251
116STK100.28204552
117MAP3K70.27109033
118RPS6KA50.26919231
119MARK20.26807757
120EIF2AK30.26705999
121PKN10.26656150
122* IGF1R0.26187267
123RPS6KA60.26155191
124ABL10.26020644
125EIF2AK20.26005306
126CDC70.25846553
127JAK20.24795913
128FRK0.24316360
129IRAK10.23969147
130TAOK30.23629167
131PRKAA20.23601304
132MAP2K40.23504737
133NUAK10.23091517
134YES10.22745499
135BUB10.22082141
136CDK40.21933841
137TAOK20.21414683
138PTK60.21099937
139CAMK40.20476404
140IRAK30.20000188

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.42125895
2Asthma_Homo sapiens_hsa053104.02521672
3Ribosome_Homo sapiens_hsa030103.74573005
4Allograft rejection_Homo sapiens_hsa053302.86677040
5Mismatch repair_Homo sapiens_hsa034302.65865514
6Autoimmune thyroid disease_Homo sapiens_hsa053202.49673297
7Base excision repair_Homo sapiens_hsa034102.37625800
8Graft-versus-host disease_Homo sapiens_hsa053322.37446511
9Type I diabetes mellitus_Homo sapiens_hsa049402.10440857
10Homologous recombination_Homo sapiens_hsa034401.97210119
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.96647177
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.87827551
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86455181
14Staphylococcus aureus infection_Homo sapiens_hsa051501.85552181
15Leishmaniasis_Homo sapiens_hsa051401.74957021
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71294768
17Renin secretion_Homo sapiens_hsa049241.70180424
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68864872
19Nucleotide excision repair_Homo sapiens_hsa034201.65562028
20Platelet activation_Homo sapiens_hsa046111.61622780
21Primary immunodeficiency_Homo sapiens_hsa053401.61474386
22N-Glycan biosynthesis_Homo sapiens_hsa005101.57698872
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.53868110
24Fatty acid degradation_Homo sapiens_hsa000711.51087651
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.50588948
26Arachidonic acid metabolism_Homo sapiens_hsa005901.50224683
27Herpes simplex infection_Homo sapiens_hsa051681.49786381
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.47865817
29Tryptophan metabolism_Homo sapiens_hsa003801.47593113
30Acute myeloid leukemia_Homo sapiens_hsa052211.47493556
31Malaria_Homo sapiens_hsa051441.42380771
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41774283
33Pertussis_Homo sapiens_hsa051331.41099568
34B cell receptor signaling pathway_Homo sapiens_hsa046621.39992673
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38490895
36Pyrimidine metabolism_Homo sapiens_hsa002401.38464630
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37200835
38* Hematopoietic cell lineage_Homo sapiens_hsa046401.36436596
39Rheumatoid arthritis_Homo sapiens_hsa053231.31772040
40Toxoplasmosis_Homo sapiens_hsa051451.29623716
41Legionellosis_Homo sapiens_hsa051341.28443261
42Thyroid cancer_Homo sapiens_hsa052161.28064132
43Measles_Homo sapiens_hsa051621.28048795
44Antigen processing and presentation_Homo sapiens_hsa046121.28012673
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.26241535
46Spliceosome_Homo sapiens_hsa030401.24617854
47Peroxisome_Homo sapiens_hsa041461.24298108
48ECM-receptor interaction_Homo sapiens_hsa045121.24162785
49Osteoclast differentiation_Homo sapiens_hsa043801.21693060
50Ovarian steroidogenesis_Homo sapiens_hsa049131.19521614
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18441328
52Glycerophospholipid metabolism_Homo sapiens_hsa005641.17796599
53Other glycan degradation_Homo sapiens_hsa005111.17160561
54Non-homologous end-joining_Homo sapiens_hsa034501.16480888
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16310093
56Small cell lung cancer_Homo sapiens_hsa052221.16180592
57Cell cycle_Homo sapiens_hsa041101.16159844
58Dorso-ventral axis formation_Homo sapiens_hsa043201.15334422
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.15006764
60Fatty acid elongation_Homo sapiens_hsa000621.14322059
61Shigellosis_Homo sapiens_hsa051311.12445627
62Glycosaminoglycan degradation_Homo sapiens_hsa005311.08283387
63Butanoate metabolism_Homo sapiens_hsa006501.05268884
64PPAR signaling pathway_Homo sapiens_hsa033201.03245632
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02870102
66NF-kappa B signaling pathway_Homo sapiens_hsa040641.02733511
67SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02214048
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01820206
69Focal adhesion_Homo sapiens_hsa045101.00506875
70* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97748513
71Propanoate metabolism_Homo sapiens_hsa006400.97576069
72Fatty acid metabolism_Homo sapiens_hsa012120.96792880
73Viral myocarditis_Homo sapiens_hsa054160.96132904
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95636790
75Glycerolipid metabolism_Homo sapiens_hsa005610.94541866
76Influenza A_Homo sapiens_hsa051640.92520878
77Hepatitis B_Homo sapiens_hsa051610.90706901
78Purine metabolism_Homo sapiens_hsa002300.90523995
79RNA degradation_Homo sapiens_hsa030180.89649258
80African trypanosomiasis_Homo sapiens_hsa051430.88780079
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87636207
82Salmonella infection_Homo sapiens_hsa051320.86558101
83Salivary secretion_Homo sapiens_hsa049700.86341175
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84643429
85Linoleic acid metabolism_Homo sapiens_hsa005910.84138750
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82044744
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75934297
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75588537
89Calcium signaling pathway_Homo sapiens_hsa040200.75030271
90HTLV-I infection_Homo sapiens_hsa051660.74852373
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74789960
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74107779
93Fanconi anemia pathway_Homo sapiens_hsa034600.73857421
94Oxytocin signaling pathway_Homo sapiens_hsa049210.71925797
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70866608
96HIF-1 signaling pathway_Homo sapiens_hsa040660.70677197
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.70434828
98TNF signaling pathway_Homo sapiens_hsa046680.69994985
99Protein export_Homo sapiens_hsa030600.66302299
100Chronic myeloid leukemia_Homo sapiens_hsa052200.65993022
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65598385
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65372207
103Pathways in cancer_Homo sapiens_hsa052000.65317324
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65289856
105Tyrosine metabolism_Homo sapiens_hsa003500.65166651
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64906995
107Apoptosis_Homo sapiens_hsa042100.64670118
108Phototransduction_Homo sapiens_hsa047440.63696352
109Renin-angiotensin system_Homo sapiens_hsa046140.62655561
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62554243
111Ether lipid metabolism_Homo sapiens_hsa005650.62285972
112RNA polymerase_Homo sapiens_hsa030200.62253474
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.62198823
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61173817
115Notch signaling pathway_Homo sapiens_hsa043300.60572060
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59609647
117Amoebiasis_Homo sapiens_hsa051460.59296866
118Olfactory transduction_Homo sapiens_hsa047400.59120579
119Nitrogen metabolism_Homo sapiens_hsa009100.59004590
120Regulation of autophagy_Homo sapiens_hsa041400.57658371
121Proteasome_Homo sapiens_hsa030500.57568091
122Protein digestion and absorption_Homo sapiens_hsa049740.57260410
123Tuberculosis_Homo sapiens_hsa051520.57244350
124VEGF signaling pathway_Homo sapiens_hsa043700.57192901
125Pentose phosphate pathway_Homo sapiens_hsa000300.56809884
126Insulin resistance_Homo sapiens_hsa049310.56634109
127Dilated cardiomyopathy_Homo sapiens_hsa054140.55904978
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55874648
129p53 signaling pathway_Homo sapiens_hsa041150.55416101
130Epstein-Barr virus infection_Homo sapiens_hsa051690.54795563
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.54286268
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53604279
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53245498
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.53149980
135Chemical carcinogenesis_Homo sapiens_hsa052040.53083511
136Hepatitis C_Homo sapiens_hsa051600.51640092
137Rap1 signaling pathway_Homo sapiens_hsa040150.50578025
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48856636
139Glutathione metabolism_Homo sapiens_hsa004800.45774108
140Pancreatic cancer_Homo sapiens_hsa052120.45718365
141Colorectal cancer_Homo sapiens_hsa052100.45573714
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.45533891
143Vitamin digestion and absorption_Homo sapiens_hsa049770.45415153
144Caffeine metabolism_Homo sapiens_hsa002320.43534238
145Adherens junction_Homo sapiens_hsa045200.43478207
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42234214
147Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41920523
148Viral carcinogenesis_Homo sapiens_hsa052030.41610925
1492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41294725
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.39986878
151ABC transporters_Homo sapiens_hsa020100.39649981
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39555783
153Ras signaling pathway_Homo sapiens_hsa040140.34104316
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.33285401
155Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32519071
156Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32484290
157Circadian entrainment_Homo sapiens_hsa047130.32019463
158Pancreatic secretion_Homo sapiens_hsa049720.30779933

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