CD36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)6.68519718
2* low-density lipoprotein particle clearance (GO:0034383)5.47556497
3* regulation of cholesterol storage (GO:0010885)4.80061786
4cellular response to epinephrine stimulus (GO:0071872)4.62488503
5triglyceride catabolic process (GO:0019433)4.57312942
6valine metabolic process (GO:0006573)4.49280625
7carnitine shuttle (GO:0006853)4.37428054
8brown fat cell differentiation (GO:0050873)4.35383565
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.30887795
10fatty acid beta-oxidation (GO:0006635)4.11427628
11response to epinephrine (GO:0071871)4.09661820
12acylglycerol catabolic process (GO:0046464)4.09444027
13neutral lipid catabolic process (GO:0046461)4.09444027
14negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.06562506
15* fatty acid transmembrane transport (GO:1902001)3.99148129
16negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.90860983
17positive regulation of fatty acid oxidation (GO:0046321)3.83786098
18biotin metabolic process (GO:0006768)3.73891796
19negative regulation of lipid storage (GO:0010888)3.71712183
20diacylglycerol metabolic process (GO:0046339)3.70875077
21white fat cell differentiation (GO:0050872)3.69748119
22positive regulation of fatty acid beta-oxidation (GO:0032000)3.68892554
23positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.67449526
24retina vasculature morphogenesis in camera-type eye (GO:0061299)3.62786447
25fatty acid oxidation (GO:0019395)3.61541956
26carnitine transmembrane transport (GO:1902603)3.59285694
27lipid oxidation (GO:0034440)3.58990510
28regulation of cAMP-dependent protein kinase activity (GO:2000479)3.55372142
29cellular response to thyroid hormone stimulus (GO:0097067)3.52469355
30* positive regulation of lipid storage (GO:0010884)3.49254874
31intracellular lipid transport (GO:0032365)3.46627202
32fatty acid catabolic process (GO:0009062)3.44377899
33amino-acid betaine transport (GO:0015838)3.40387934
34carnitine transport (GO:0015879)3.40387934
35regulation of fatty acid oxidation (GO:0046320)3.39145890
36negative regulation of erythrocyte differentiation (GO:0045647)3.38474795
37surfactant homeostasis (GO:0043129)3.34838782
38ovulation from ovarian follicle (GO:0001542)3.34816991
39barbed-end actin filament capping (GO:0051016)3.32808995
40* lipid storage (GO:0019915)3.31988457
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31439349
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.31439349
43modulation by symbiont of host immune response (GO:0052553)3.31439349
44positive regulation by symbiont of host defense response (GO:0052509)3.31439349
45modulation by symbiont of host defense response (GO:0052031)3.31439349
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31439349
47growth hormone receptor signaling pathway (GO:0060396)3.21738767
48neutrophil activation involved in immune response (GO:0002283)3.21271559
49tricarboxylic acid cycle (GO:0006099)3.20607609
50vascular endothelial growth factor signaling pathway (GO:0038084)3.20383600
51response to dietary excess (GO:0002021)3.18817704
52positive regulation of lipoprotein lipase activity (GO:0051006)3.18327711
53positive regulation of triglyceride lipase activity (GO:0061365)3.18327711
54polyol transport (GO:0015791)3.17366470
55alpha-linolenic acid metabolic process (GO:0036109)3.13586751
56negative regulation of macrophage differentiation (GO:0045650)3.13388066
57branched-chain amino acid metabolic process (GO:0009081)3.11019710
58protoporphyrinogen IX biosynthetic process (GO:0006782)3.10110732
59protoporphyrinogen IX metabolic process (GO:0046501)3.09437100
60lipid particle organization (GO:0034389)3.08774529
61* regulation of macrophage derived foam cell differentiation (GO:0010743)3.06909604
62CDP-diacylglycerol biosynthetic process (GO:0016024)3.06757282
63* regulation of lipid storage (GO:0010883)3.06651815
64triglyceride biosynthetic process (GO:0019432)3.05040861
65keratan sulfate catabolic process (GO:0042340)3.04552673
66triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.04015513
67regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.03414140
68transcytosis (GO:0045056)3.03192949
69oxaloacetate metabolic process (GO:0006107)3.03168205
70positive regulation of lipid catabolic process (GO:0050996)3.02253618
71ethanol oxidation (GO:0006069)3.01658989
72membrane raft organization (GO:0031579)3.01503261
73tricarboxylic acid metabolic process (GO:0072350)3.01183735
74regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.00797542
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.00251806
76negative regulation of phagocytosis (GO:0050765)2.96269337
77regulation of interferon-beta biosynthetic process (GO:0045357)2.96083039
78branched-chain amino acid catabolic process (GO:0009083)2.95873419
79phosphatidic acid biosynthetic process (GO:0006654)2.95625303
80phosphatidic acid metabolic process (GO:0046473)2.95625303
81regulation of glycogen (starch) synthase activity (GO:2000465)2.93621358
82neutral lipid biosynthetic process (GO:0046460)2.92906893
83acylglycerol biosynthetic process (GO:0046463)2.92906893
84glomerular filtration (GO:0003094)2.90687493
85acetyl-CoA metabolic process (GO:0006084)2.89605670
86* plasma lipoprotein particle clearance (GO:0034381)2.87823613
87positive regulation of glomerulus development (GO:0090193)2.87585087
88CDP-diacylglycerol metabolic process (GO:0046341)2.85177319
89glycerolipid catabolic process (GO:0046503)2.84893487
90positive regulation of gamma-delta T cell activation (GO:0046645)2.82742257
91regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.82724002
922-oxoglutarate metabolic process (GO:0006103)2.82645414
93positive regulation of p38MAPK cascade (GO:1900745)2.82460170
94positive regulation of cellular amide metabolic process (GO:0034250)2.81819195
95regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.81077600
96potassium ion export (GO:0071435)2.80155668
97regulation of lipoprotein metabolic process (GO:0050746)2.80036499
98regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.79528793
99regulation of fatty acid beta-oxidation (GO:0031998)2.79103600
100regulation of cholesterol efflux (GO:0010874)2.78374192
101positive regulation of interferon-alpha production (GO:0032727)2.77535299
102detection of molecule of bacterial origin (GO:0032490)2.76954067
103acyl-CoA biosynthetic process (GO:0071616)2.76026997
104thioester biosynthetic process (GO:0035384)2.76026997
105cellular response to growth hormone stimulus (GO:0071378)2.75133895
106* response to hydroperoxide (GO:0033194)2.74497554
107monocarboxylic acid catabolic process (GO:0072329)2.74469048
108iron ion import (GO:0097286)2.74108899
109regulation of triglyceride catabolic process (GO:0010896)2.73156382
110triglyceride metabolic process (GO:0006641)2.72861822
111complement activation, alternative pathway (GO:0006957)2.72395670
112negative regulation of protein autophosphorylation (GO:0031953)2.71932387
113positive regulation of fatty acid metabolic process (GO:0045923)2.69235607
114regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.66256259
115carnitine metabolic process (GO:0009437)2.64741387
116positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.64101118
117fatty acid homeostasis (GO:0055089)2.64033528
118response to vitamin E (GO:0033197)2.61312414
119negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.59881384
120quaternary ammonium group transport (GO:0015697)2.59731160
121negative regulation of granulocyte differentiation (GO:0030853)2.59717172
122regulation of interferon-alpha production (GO:0032647)2.59210914
123positive regulation of cholesterol efflux (GO:0010875)2.57343657
124positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.56705323
125regulation of cholesterol transport (GO:0032374)2.56409612
126regulation of sterol transport (GO:0032371)2.56409612
127regulation of platelet activation (GO:0010543)2.56147209
128acylglycerol metabolic process (GO:0006639)2.55932288
129* positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.55524817
130chemical homeostasis within a tissue (GO:0048875)2.55231099
131renal filtration (GO:0097205)2.55135841
132fatty-acyl-CoA metabolic process (GO:0035337)2.54609604
133negative regulation of protein localization to plasma membrane (GO:1903077)2.54064146
134positive regulation of cholesterol transport (GO:0032376)2.53857096
135positive regulation of sterol transport (GO:0032373)2.53857096
136glycerol metabolic process (GO:0006071)2.53145919
137detection of other organism (GO:0098543)2.52742833
138negative regulation of smooth muscle cell migration (GO:0014912)2.51623265
139angiogenesis involved in wound healing (GO:0060055)2.51018817
140neutral lipid metabolic process (GO:0006638)2.50876895
141cellular response to zinc ion (GO:0071294)2.50405142
142regulation of macrophage chemotaxis (GO:0010758)2.49266467
143positive regulation of receptor recycling (GO:0001921)2.49229584
144phospholipid homeostasis (GO:0055091)2.48929991
145tyrosine phosphorylation of STAT protein (GO:0007260)2.47825124
146NADH metabolic process (GO:0006734)2.47621175
147positive regulation of mast cell activation (GO:0033005)2.47539213
148response to thyroid hormone (GO:0097066)2.47433840
149wound healing, spreading of epidermal cells (GO:0035313)2.46922660
150regulation of acyl-CoA biosynthetic process (GO:0050812)2.45664224
151succinate metabolic process (GO:0006105)2.45232712
152response to lipoprotein particle (GO:0055094)2.44629880
153negative regulation of nitric-oxide synthase activity (GO:0051001)2.44225663
154regulation of mononuclear cell migration (GO:0071675)2.43283561
155antigen processing and presentation of endogenous antigen (GO:0019883)2.42753510
156antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.42414948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.83989014
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.23856847
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.98318466
4* GATA1_22025678_ChIP-Seq_K562_Human3.56142625
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.50818162
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.33065156
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.21765888
8CLOCK_20551151_ChIP-Seq_293T_Human3.21605446
9* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.86569750
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.80978679
11* LXR_22158963_ChIP-Seq_LIVER_Mouse2.67632281
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48418474
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.43093134
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.42926752
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35969800
16SCL_19346495_ChIP-Seq_HPC-7_Human2.27369950
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20469546
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19153876
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.14724159
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.14366704
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13378054
22GATA2_21666600_ChIP-Seq_HMVEC_Human2.10915201
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.08093023
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02183530
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96553097
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80523767
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79509824
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77108005
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76875774
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.72353108
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.71420089
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70709710
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69074402
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63845333
35* TBX20_22080862_ChIP-Seq_HEART_Mouse1.62369214
36* TBX20_22328084_ChIP-Seq_HEART_Mouse1.62369214
37* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60237283
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.59937487
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58609749
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54914646
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54319149
42VDR_24787735_ChIP-Seq_THP-1_Human1.50022110
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.48813191
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48117635
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.47328242
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45297343
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44654373
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43537344
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40870976
50* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.40701371
51CJUN_26792858_Chip-Seq_BT549_Human1.39070035
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38635762
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38635762
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.38539449
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37958502
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31598767
57* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.30158208
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29504047
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.27124242
60GATA1_19941827_ChIP-Seq_MEL86_Mouse1.26844312
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26038385
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24039685
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19705872
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.18992801
65* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18909788
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.16684281
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16437671
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16413319
69RUNX_20019798_ChIP-Seq_JUKART_Human1.15471736
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14918046
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.14871541
72SPI1_23127762_ChIP-Seq_K562_Human1.14659406
73SOX2_20726797_ChIP-Seq_SW620_Human1.14518200
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11069071
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10767397
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08796245
77GATA1_19941826_ChIP-Seq_K562_Human1.08460647
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.08389261
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06181962
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05180844
81SPI1_23547873_ChIP-Seq_NB4_Human1.04992899
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04041715
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02994816
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00280045
85GATA4_21415370_ChIP-Seq_HL-1_Mouse0.99204174
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97856100
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97210283
88GATA2_19941826_ChIP-Seq_K562_Human0.96239711
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95575006
90* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94556588
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94354723
92* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94326876
93SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94277431
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93591966
95GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93468244
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92613481
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92098840
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91866851
99* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90895547
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90870741
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90564832
102* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88567396
103ZNF263_19887448_ChIP-Seq_K562_Human0.88255723
104STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88021154
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87436076
106TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87187642
107* FOXA2_19822575_ChIP-Seq_HepG2_Human0.86575841
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85449765
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84973195
110* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84198583
111* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84198583
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84046722
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83688147
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83373479
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83201637
116PU_27001747_Chip-Seq_BMDM_Mouse0.83047029
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81575443
118* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81259307
119* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80956759
120RXR_22108803_ChIP-Seq_LS180_Human0.80305933
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77873169
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77799808
123GATA4_25053715_ChIP-Seq_YYC3_Human0.77605270
124NR3C1_23031785_ChIP-Seq_PC12_Mouse0.76394983
125SPI1_20517297_ChIP-Seq_HL60_Human0.76209543
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.76193663
127VDR_24763502_ChIP-Seq_THP-1_Human0.74956356
128HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72870255
129MAF_26560356_Chip-Seq_TH1_Human0.72719324
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71566505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.61587633
2* MP0004130_abnormal_muscle_cell3.55442705
3MP0003191_abnormal_cellular_cholesterol3.29128612
4MP0005666_abnormal_adipose_tissue3.27603774
5MP0004185_abnormal_adipocyte_glucose3.00534703
6MP0003724_increased_susceptibility_to2.81476527
7MP0008438_abnormal_cutaneous_collagen2.61992753
8MP0002837_dystrophic_cardiac_calcinosis2.52972284
9MP0005375_adipose_tissue_phenotype2.38876096
10MP0003828_pulmonary_edema2.34942533
11MP0003705_abnormal_hypodermis_morpholog2.11539902
12MP0002971_abnormal_brown_adipose2.09812862
13MP0005058_abnormal_lysosome_morphology2.07812736
14MP0003303_peritoneal_inflammation2.04106398
15MP0001879_abnormal_lymphatic_vessel1.88332234
16MP0005360_urolithiasis1.87224002
17* MP0010329_abnormal_lipoprotein_level1.86781871
18MP0005167_abnormal_blood-brain_barrier1.85762888
19MP0010368_abnormal_lymphatic_system1.79040290
20MP0009115_abnormal_fat_cell1.78517463
21MP0000013_abnormal_adipose_tissue1.75188954
22MP0004084_abnormal_cardiac_muscle1.74384328
23MP0001835_abnormal_antigen_presentation1.72572558
24MP0003646_muscle_fatigue1.71562906
25* MP0000343_altered_response_to1.68076374
26MP0000003_abnormal_adipose_tissue1.62322042
27MP0004272_abnormal_basement_membrane1.61385265
28MP0003436_decreased_susceptibility_to1.60520156
29MP0003656_abnormal_erythrocyte_physiolo1.60044535
30MP0004215_abnormal_myocardial_fiber1.59314123
31MP0003950_abnormal_plasma_membrane1.57871924
32MP0002332_abnormal_exercise_endurance1.57015531
33MP0008775_abnormal_heart_ventricle1.55765382
34MP0005275_abnormal_skin_tensile1.55470072
35MP0004782_abnormal_surfactant_physiolog1.54823068
36MP0005334_abnormal_fat_pad1.53506097
37* MP0002118_abnormal_lipid_homeostasis1.47864047
38MP0006036_abnormal_mitochondrial_physio1.47298669
39MP0003566_abnormal_cell_adhesion1.46722383
40MP0006138_congestive_heart_failure1.41608565
41MP0003186_abnormal_redox_activity1.39669820
42MP0001958_emphysema1.36896973
43* MP0005385_cardiovascular_system_phenoty1.36887927
44* MP0001544_abnormal_cardiovascular_syste1.36887927
45MP0005330_cardiomyopathy1.35945160
46MP0002972_abnormal_cardiac_muscle1.34396730
47MP0002139_abnormal_hepatobiliary_system1.34145214
48MP0005464_abnormal_platelet_physiology1.33764459
49MP0000751_myopathy1.32785383
50MP0004036_abnormal_muscle_relaxation1.31528671
51MP0003011_delayed_dark_adaptation1.27203204
52MP0004087_abnormal_muscle_fiber1.26930405
53MP0003300_gastrointestinal_ulcer1.26762782
54MP0000750_abnormal_muscle_regeneration1.25884133
55MP0000747_muscle_weakness1.25535674
56* MP0003690_abnormal_glial_cell1.25253715
57* MP0002419_abnormal_innate_immunity1.24368483
58MP0001533_abnormal_skeleton_physiology1.23879735
59MP0004510_myositis1.22762233
60MP0000609_abnormal_liver_physiology1.21521075
61MP0005397_hematopoietic_system_phenotyp1.21157525
62MP0001545_abnormal_hematopoietic_system1.21157525
63MP0001881_abnormal_mammary_gland1.20648038
64MP0009840_abnormal_foam_cell1.20223458
65MP0005535_abnormal_body_temperature1.17461697
66MP0001853_heart_inflammation1.17213047
67MP0001661_extended_life_span1.15230378
68MP0005620_abnormal_muscle_contractility1.14205533
69MP0005448_abnormal_energy_balance1.13818804
70MP0003279_aneurysm1.12384084
71MP0003075_altered_response_to1.10194982
72MP0000759_abnormal_skeletal_muscle1.09539767
73MP0006082_CNS_inflammation1.09334552
74MP0003448_altered_tumor_morphology1.09215210
75MP0005164_abnormal_response_to1.08598691
76MP0002970_abnormal_white_adipose1.08569459
77* MP0009785_altered_susceptibility_to1.08465600
78MP0000858_altered_metastatic_potential1.07935391
79MP0004147_increased_porphyrin_level1.07022515
80MP0010630_abnormal_cardiac_muscle1.05641180
81MP0005319_abnormal_enzyme/_coenzyme1.04009197
82MP0002876_abnormal_thyroid_physiology1.03172453
83MP0002877_abnormal_melanocyte_morpholog1.03158909
84MP0002166_altered_tumor_susceptibility1.03146496
85MP0009764_decreased_sensitivity_to1.02422687
86MP0005365_abnormal_bile_salt1.02413426
87MP0000249_abnormal_blood_vessel1.02088659
88MP0008004_abnormal_stomach_pH1.01961344
89MP0002148_abnormal_hypersensitivity_rea1.01610204
90MP0002254_reproductive_system_inflammat1.01286143
91* MP0005025_abnormal_response_to1.00172656
92MP0003045_fibrosis0.97848716
93MP0002138_abnormal_hepatobiliary_system0.97481539
94MP0009643_abnormal_urine_homeostasis0.96050848
95MP0002638_abnormal_pupillary_reflex0.95603317
96MP0001986_abnormal_taste_sensitivity0.94753400
97MP0000749_muscle_degeneration0.94253429
98MP0005584_abnormal_enzyme/coenzyme_acti0.93337993
99MP0005452_abnormal_adipose_tissue0.92980014
100MP0002998_abnormal_bone_remodeling0.92567648
101* MP0002078_abnormal_glucose_homeostasis0.91690056
102MP0004484_altered_response_of0.91493986
103MP0005000_abnormal_immune_tolerance0.90675324
104MP0005647_abnormal_sex_gland0.90232792
105MP0002295_abnormal_pulmonary_circulatio0.89867539
106MP0003172_abnormal_lysosome_physiology0.89170898
107MP0005165_increased_susceptibility_to0.89132605
108MP0009780_abnormal_chondrocyte_physiolo0.88316237
109MP0001756_abnormal_urination0.88160789
110MP0003221_abnormal_cardiomyocyte_apopto0.87646395
111MP0001790_abnormal_immune_system0.86966226
112MP0005387_immune_system_phenotype0.86966226
113MP0004883_abnormal_blood_vessel0.85565019
114MP0002133_abnormal_respiratory_system0.85374597
115MP0005388_respiratory_system_phenotype0.85374597
116MP0008260_abnormal_autophagy0.85161614
117* MP0008469_abnormal_protein_level0.85142346
118MP0005332_abnormal_amino_acid0.84650239
119MP0003959_abnormal_lean_body0.83999316
120MP0000604_amyloidosis0.83310350
121* MP0009763_increased_sensitivity_to0.82946293
122MP0002269_muscular_atrophy0.82374724
123MP0005083_abnormal_biliary_tract0.78857126
124MP0005171_absent_coat_pigmentation0.78775592
125MP0005266_abnormal_metabolism0.77561003
126MP0005595_abnormal_vascular_smooth0.72155892
127MP0003868_abnormal_feces_composition0.71618333
128MP0000465_gastrointestinal_hemorrhage0.69185201
129MP0002009_preneoplasia0.68584092
130MP0002106_abnormal_muscle_physiology0.68466820
131MP0004145_abnormal_muscle_electrophysio0.67794321

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)4.35992595
2Abnormality of glycosphingolipid metabolism (HP:0004343)4.35992595
3Abnormality of glycolipid metabolism (HP:0010969)4.35992595
4Oligomenorrhea (HP:0000876)4.07415101
5Acanthosis nigricans (HP:0000956)3.69521967
6Recurrent gram-negative bacterial infections (HP:0005420)3.63504512
7Hypertriglyceridemia (HP:0002155)3.61822479
8Myoglobinuria (HP:0002913)3.59384246
9Frequent falls (HP:0002359)3.58951033
10Eczematoid dermatitis (HP:0000976)3.50321896
11Myocardial infarction (HP:0001658)3.48033967
12Hyperglycinuria (HP:0003108)3.42332612
13Systemic lupus erythematosus (HP:0002725)3.39361468
14Nausea (HP:0002018)3.34255125
15Abnormality of skeletal muscle fiber size (HP:0012084)3.28317347
16Bone cyst (HP:0012062)3.27789726
17Abnormality of fatty-acid metabolism (HP:0004359)3.25954459
18Complement deficiency (HP:0004431)3.20427731
19Increased cerebral lipofuscin (HP:0011813)3.18538432
20Increased connective tissue (HP:0009025)3.17863712
21Hypoglycemic coma (HP:0001325)3.12931756
22Muscle fiber splitting (HP:0003555)3.10644297
23Hematochezia (HP:0002573)3.10004725
24Vacuolated lymphocytes (HP:0001922)3.05055544
25Difficulty running (HP:0009046)3.04815176
26Reduced subcutaneous adipose tissue (HP:0003758)2.99476421
27Recurrent abscess formation (HP:0002722)2.99293783
28Axonal loss (HP:0003447)2.97594958
29Hypoalphalipoproteinemia (HP:0003233)2.94812813
30Sudden death (HP:0001699)2.91717835
31Rhabdomyolysis (HP:0003201)2.87060237
32Lipoatrophy (HP:0100578)2.85730407
33Ventricular tachycardia (HP:0004756)2.83868012
34Polycythemia (HP:0001901)2.83706805
35Abnormality of the heme biosynthetic pathway (HP:0010472)2.82908426
36Paralysis (HP:0003470)2.82610773
37Bundle branch block (HP:0011710)2.81031590
38Hypercholesterolemia (HP:0003124)2.79272789
39Ketoacidosis (HP:0001993)2.79147418
40Right ventricular cardiomyopathy (HP:0011663)2.70296356
41Abnormality of complement system (HP:0005339)2.69446477
42Abnormality of macrophages (HP:0004311)2.68452383
43Abnormality of serine family amino acid metabolism (HP:0010894)2.67306684
44Abnormality of glycine metabolism (HP:0010895)2.67306684
45Esophageal varix (HP:0002040)2.63693335
46Autoimmune thrombocytopenia (HP:0001973)2.61882509
47Recurrent bacterial skin infections (HP:0005406)2.61005579
48Amyloidosis (HP:0011034)2.59941323
49Tetraparesis (HP:0002273)2.59565422
50Asymmetric septal hypertrophy (HP:0001670)2.58520266
51Hyporeflexia of lower limbs (HP:0002600)2.57799873
52Hyperlipoproteinemia (HP:0010980)2.54269306
53Xanthomatosis (HP:0000991)2.54243732
54Neck muscle weakness (HP:0000467)2.53690585
55Hydroxyprolinuria (HP:0003080)2.49901039
56Abnormality of proline metabolism (HP:0010907)2.49901039
57Skin nodule (HP:0200036)2.48903228
58Hemorrhage of the eye (HP:0011885)2.48410582
59Facial diplegia (HP:0001349)2.46934787
60Insulin-resistant diabetes mellitus (HP:0000831)2.46417865
61Exercise-induced muscle cramps (HP:0003710)2.45713882
62Epidermoid cyst (HP:0200040)2.45138559
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.44136184
64Ketosis (HP:0001946)2.43871912
65Colitis (HP:0002583)2.43819984
66EMG: myopathic abnormalities (HP:0003458)2.43767116
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43671850
68Dicarboxylic aciduria (HP:0003215)2.43671850
69Spontaneous hematomas (HP:0007420)2.41002566
70Cerebral aneurysm (HP:0004944)2.38289838
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.36926713
72Type 1 muscle fiber predominance (HP:0003803)2.36127074
73Muscle fiber inclusion bodies (HP:0100299)2.35496169
74Interstitial pulmonary disease (HP:0006530)2.33880211
75Nemaline bodies (HP:0003798)2.33674307
76Exercise-induced myalgia (HP:0003738)2.33424927
77Hyperammonemia (HP:0001987)2.32014751
78Mucosal telangiectasiae (HP:0100579)2.31771722
79Loss of speech (HP:0002371)2.29547455
80Poikilocytosis (HP:0004447)2.29104177
81Ventricular fibrillation (HP:0001663)2.28100953
82Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.27489504
83Abnormality of the periventricular white matter (HP:0002518)2.27436916
84Nephritis (HP:0000123)2.25388930
85Cerebral hemorrhage (HP:0001342)2.25359492
86Palpitations (HP:0001962)2.23815818
87Hepatosplenomegaly (HP:0001433)2.23325483
88Distal lower limb muscle weakness (HP:0009053)2.22163461
89* Prolonged bleeding time (HP:0003010)2.21727315
90Atrial fibrillation (HP:0005110)2.20688212
91Dysostosis multiplex (HP:0000943)2.17331164
92Neoplasm of head and neck (HP:0012288)2.17330615
93Esophageal neoplasm (HP:0100751)2.17330615
94Pigmentary retinal degeneration (HP:0001146)2.16771894
95Abnormality of polysaccharide metabolism (HP:0011012)2.16463891
96Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16463891
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16463891
98Purpura (HP:0000979)2.15657417
99Disinhibition (HP:0000734)2.15059932
100Generalized aminoaciduria (HP:0002909)2.13589704
101Vertebral compression fractures (HP:0002953)2.13479433
102Conjunctival hamartoma (HP:0100780)2.13306612
103Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13134147
104Insulin resistance (HP:0000855)2.12327712
105Growth hormone excess (HP:0000845)2.11224278
106Abnormality of purine metabolism (HP:0004352)2.11161681
107Increased muscle lipid content (HP:0009058)2.10359671
108Abnormal atrioventricular conduction (HP:0005150)2.09904910
109Increased serum pyruvate (HP:0003542)2.08482568
110Heart block (HP:0012722)2.06797786
111Atrioventricular block (HP:0001678)2.06002660
112Broad metatarsal (HP:0001783)2.04875496
113Gingivitis (HP:0000230)1.99548308
114Primary atrial arrhythmia (HP:0001692)1.99290047
115Glomerulonephritis (HP:0000099)1.98880116
116Mutism (HP:0002300)1.98377485
117Osteolytic defects of the hand bones (HP:0009699)1.98313166
118Osteolytic defects of the phalanges of the hand (HP:0009771)1.98313166
119Dilated cardiomyopathy (HP:0001644)1.95773462
120Toxemia of pregnancy (HP:0100603)1.94357800
121Ventricular arrhythmia (HP:0004308)1.93839230
122Abnormality of glycolysis (HP:0004366)1.93709190
123Abnormality of the lumbar spine (HP:0100712)1.93286138
124Fatigue (HP:0012378)1.93283642
125Abnormal hemoglobin (HP:0011902)1.92304040
126Supraventricular arrhythmia (HP:0005115)1.91836730
127Mucopolysacchariduria (HP:0008155)1.88690940
128Urinary glycosaminoglycan excretion (HP:0003541)1.88690940
129Subcapsular cataract (HP:0000523)1.87115008
130Calf muscle hypertrophy (HP:0008981)1.87089856
131Multiple enchondromatosis (HP:0005701)1.86593359
132Joint hemorrhage (HP:0005261)1.86495080
133Abnormality of the nasal mucosa (HP:0000433)1.85971374
134Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85689642
135Foot dorsiflexor weakness (HP:0009027)1.85673704
136Increased variability in muscle fiber diameter (HP:0003557)1.84852818
137Diaphragmatic weakness (HP:0009113)1.84737187
138Rimmed vacuoles (HP:0003805)1.84691588
139Pancreatitis (HP:0001733)1.84259445
140Centrally nucleated skeletal muscle fibers (HP:0003687)1.82943872
141Epistaxis (HP:0000421)1.82272891
142Keratoconjunctivitis sicca (HP:0001097)1.82081694
143Abnormality of the foot musculature (HP:0001436)1.79734921
144Inflammation of the large intestine (HP:0002037)1.79597064
145Cerebral inclusion bodies (HP:0100314)1.78776721

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.10803825
2TRIB33.96390586
3CAMK1D3.38077587
4RIPK12.62115224
5TTN2.60231221
6BCKDK2.51569838
7TGFBR22.50509375
8ERN12.32672397
9PRPF4B2.24221763
10PDK32.23800833
11PDK42.23800833
12SIK12.15407367
13CAMK1G2.15166565
14NEK91.94018377
15PDK21.90814829
16MAP3K131.86944792
17PKN21.85074446
18KDR1.84795105
19LMTK21.83212792
20DDR21.69891166
21FGFR31.66388914
22MAP3K61.66023368
23TBK11.65315649
24MST1R1.61443040
25CCNB11.57259089
26OBSCN1.55078640
27JAK11.53715419
28TYK21.49582907
29FES1.48079824
30MAPK41.42341186
31MYLK1.40985429
32RIPK41.39571666
33IRAK31.33861239
34MAP2K31.32925576
35MAP3K141.32355955
36CAMKK21.31004571
37FGFR41.29725941
38CAMK11.27318264
39PRKAA21.26317425
40PBK1.24099485
41PKN11.21527255
42KIT1.20429951
43ERBB31.19991931
44EEF2K1.19662238
45MAPKAPK31.19383275
46EPHB11.16949663
47DMPK1.14181888
48JAK21.13904876
49CSK1.11406338
50MAP3K31.08682256
51PIK3CG1.04055421
52JAK31.03902848
53PHKG21.03827230
54PHKG11.03827230
55NME20.99712868
56GRK70.97843323
57PDGFRA0.95715228
58PDPK10.94608437
59CDK60.94094544
60BTK0.93491836
61ABL20.93422805
62INSRR0.93115214
63MAPK70.89982843
64SCYL20.87344732
65TRPM70.87338914
66BLK0.85712650
67LRRK20.85680776
68PIK3CA0.84415335
69ARAF0.84148193
70BRAF0.82822532
71MOS0.81554137
72PTK60.81493073
73PTK2B0.78714964
74PRKD10.78330872
75STK240.77943851
76CSF1R0.77182491
77IRAK40.75651146
78MAP4K10.75053841
79PDK10.73091447
80PRKCH0.72782484
81BMPR20.72386371
82PDGFRB0.71157042
83ZAP700.70394673
84EPHB20.69898586
85MAPKAPK50.68542499
86MAP3K10.68008757
87BMX0.66248470
88FGFR20.65402790
89GSK3A0.63626342
90IKBKE0.62901181
91ILK0.61800355
92TEC0.61428907
93KSR20.60655026
94CDK90.60203354
95LYN0.59893655
96MARK30.59257578
97FLT30.58834243
98IKBKB0.58581955
99GRK50.58009444
100IGF1R0.57944504
101PRKAA10.57858336
102MET0.57690871
103TESK10.56188773
104ABL10.55261247
105MAPK120.53499427
106MAP2K10.53187472
107FER0.51873557
108HCK0.50989509
109FRK0.50181378
110PINK10.50017153
111NLK0.49254715
112PRKACB0.49072735
113PIM20.48705443
114PRKG10.48589898
115BRSK20.47876448
116EPHA30.47867751
117FGR0.47607955
118TGFBR10.47102058
119MAP3K50.45794718
120PRKACG0.45335493
121EGFR0.44714316
122ADRBK10.44659539
123DAPK20.43930057
124TNK20.43598004
125LATS20.43009123
126MAPK30.42095172
127RET0.42005984
128DAPK30.41333281
129PRKG20.41008699
130TAOK20.40701848
131MAP2K40.38920210
132CDC42BPA0.38278762
133STK100.36604660
134ITK0.36319422
135SGK30.35637139
136STK40.35113974
137LATS10.33656196
138STK30.31701594
139SYK0.31548178

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.53979668
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.45416064
3* PPAR signaling pathway_Homo sapiens_hsa033203.23834701
4Fatty acid degradation_Homo sapiens_hsa000713.13951597
5Fatty acid metabolism_Homo sapiens_hsa012122.99189820
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.94585025
7Fatty acid biosynthesis_Homo sapiens_hsa000612.84465652
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.51311577
9Caffeine metabolism_Homo sapiens_hsa002322.48560145
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43737103
11Staphylococcus aureus infection_Homo sapiens_hsa051502.37079743
12Glycerolipid metabolism_Homo sapiens_hsa005611.77088348
13beta-Alanine metabolism_Homo sapiens_hsa004101.61638070
14Carbon metabolism_Homo sapiens_hsa012001.60113058
15* Adipocytokine signaling pathway_Homo sapiens_hsa049201.58211236
16Pyruvate metabolism_Homo sapiens_hsa006201.54920350
17Lysosome_Homo sapiens_hsa041421.52904497
18Peroxisome_Homo sapiens_hsa041461.47509625
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46740173
20Complement and coagulation cascades_Homo sapiens_hsa046101.42465545
21Histidine metabolism_Homo sapiens_hsa003401.27753665
22Fatty acid elongation_Homo sapiens_hsa000621.23775915
23Tryptophan metabolism_Homo sapiens_hsa003801.22843266
24Leishmaniasis_Homo sapiens_hsa051401.18249786
25Butanoate metabolism_Homo sapiens_hsa006501.14665377
26Nitrogen metabolism_Homo sapiens_hsa009101.13679104
27* Insulin resistance_Homo sapiens_hsa049311.13511259
28Asthma_Homo sapiens_hsa053101.09308458
29Osteoclast differentiation_Homo sapiens_hsa043801.08067370
30Pertussis_Homo sapiens_hsa051331.06025643
31Viral myocarditis_Homo sapiens_hsa054161.05475002
32Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98496597
33Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98141075
34* AMPK signaling pathway_Homo sapiens_hsa041520.97624359
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97234158
36Tuberculosis_Homo sapiens_hsa051520.94862292
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94760579
38Glycerophospholipid metabolism_Homo sapiens_hsa005640.94615067
39Glycosaminoglycan degradation_Homo sapiens_hsa005310.93138053
40Arginine biosynthesis_Homo sapiens_hsa002200.91527602
41Legionellosis_Homo sapiens_hsa051340.91297657
42Toxoplasmosis_Homo sapiens_hsa051450.89764161
43Ovarian steroidogenesis_Homo sapiens_hsa049130.89311253
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87539261
45Allograft rejection_Homo sapiens_hsa053300.87253405
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83811811
47* Phagosome_Homo sapiens_hsa041450.82988589
48Starch and sucrose metabolism_Homo sapiens_hsa005000.81403710
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.81062492
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.81032884
51Systemic lupus erythematosus_Homo sapiens_hsa053220.78221408
52Dilated cardiomyopathy_Homo sapiens_hsa054140.77458271
53Phenylalanine metabolism_Homo sapiens_hsa003600.76964019
54* Malaria_Homo sapiens_hsa051440.76469622
55* Hematopoietic cell lineage_Homo sapiens_hsa046400.76408744
56Graft-versus-host disease_Homo sapiens_hsa053320.75045794
57Autoimmune thyroid disease_Homo sapiens_hsa053200.75006197
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74105807
59Focal adhesion_Homo sapiens_hsa045100.73865116
60Rheumatoid arthritis_Homo sapiens_hsa053230.73267432
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73256182
62Insulin signaling pathway_Homo sapiens_hsa049100.73191703
63Amoebiasis_Homo sapiens_hsa051460.71469259
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.70742643
65Sulfur metabolism_Homo sapiens_hsa009200.68848022
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68361992
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66914158
68Other glycan degradation_Homo sapiens_hsa005110.64396540
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64390673
70ABC transporters_Homo sapiens_hsa020100.64287942
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61179839
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.60285363
73* Fat digestion and absorption_Homo sapiens_hsa049750.58501987
74Salmonella infection_Homo sapiens_hsa051320.58426461
75HIF-1 signaling pathway_Homo sapiens_hsa040660.58073153
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57539105
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57241087
78Dorso-ventral axis formation_Homo sapiens_hsa043200.57190491
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56339111
80Collecting duct acid secretion_Homo sapiens_hsa049660.54335046
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52487065
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.50254812
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49795068
84Pentose phosphate pathway_Homo sapiens_hsa000300.49660052
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49313427
86* ECM-receptor interaction_Homo sapiens_hsa045120.49029083
87Type II diabetes mellitus_Homo sapiens_hsa049300.47614784
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.47276312
89Platelet activation_Homo sapiens_hsa046110.47035733
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45604311
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45428312
92Renin secretion_Homo sapiens_hsa049240.45350148
93Adherens junction_Homo sapiens_hsa045200.45270915
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45048263
95TNF signaling pathway_Homo sapiens_hsa046680.44054582
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43701075
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43650649
98Antigen processing and presentation_Homo sapiens_hsa046120.43535512
99B cell receptor signaling pathway_Homo sapiens_hsa046620.43421590
100Tyrosine metabolism_Homo sapiens_hsa003500.43097709
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42995033
102Renin-angiotensin system_Homo sapiens_hsa046140.41253060
103Proteoglycans in cancer_Homo sapiens_hsa052050.40907107
104Influenza A_Homo sapiens_hsa051640.40159853
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40024301
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39244909
107FoxO signaling pathway_Homo sapiens_hsa040680.38672316
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.38461390
109Glucagon signaling pathway_Homo sapiens_hsa049220.37766205
110GnRH signaling pathway_Homo sapiens_hsa049120.37187589
111Apoptosis_Homo sapiens_hsa042100.36826499
112Measles_Homo sapiens_hsa051620.36782676
113Lysine degradation_Homo sapiens_hsa003100.36779818
114Hepatitis C_Homo sapiens_hsa051600.36419274
115Acute myeloid leukemia_Homo sapiens_hsa052210.35112032
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33570009
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33447453
118Bile secretion_Homo sapiens_hsa049760.32718272
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32473658
120Chemokine signaling pathway_Homo sapiens_hsa040620.32347572
121Type I diabetes mellitus_Homo sapiens_hsa049400.32005621
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31379359
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30447648
124African trypanosomiasis_Homo sapiens_hsa051430.30240292
125Small cell lung cancer_Homo sapiens_hsa052220.29379133
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28992094
127Galactose metabolism_Homo sapiens_hsa000520.28763094
128Glutathione metabolism_Homo sapiens_hsa004800.28118500
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.26573706
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26160046
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25743730

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