CD37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)6.58791083
2antigen processing and presentation of endogenous antigen (GO:0019883)6.51909616
3positive regulation of gamma-delta T cell activation (GO:0046645)6.51036205
4regulation of B cell receptor signaling pathway (GO:0050855)5.83576518
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.77797121
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.77797121
7regulation of B cell differentiation (GO:0045577)5.22819993
8positive regulation of B cell differentiation (GO:0045579)5.15084959
9regulation of gamma-delta T cell differentiation (GO:0045586)4.97362389
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.85501037
11detection of bacterium (GO:0016045)4.64820658
12regulation of gamma-delta T cell activation (GO:0046643)4.60922327
13detection of other organism (GO:0098543)4.57768968
14positive thymic T cell selection (GO:0045059)4.48535122
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.34076805
16cellular response to zinc ion (GO:0071294)4.32183790
17negative regulation of cell killing (GO:0031342)4.23556089
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.23556089
19response to interleukin-15 (GO:0070672)4.06420636
20negative regulation of phagocytosis (GO:0050765)4.02084551
21leukocyte aggregation (GO:0070486)3.96127733
22cellular response to interleukin-15 (GO:0071350)3.95796741
23regulation of interferon-beta biosynthetic process (GO:0045357)3.91454970
24negative regulation of lymphocyte mediated immunity (GO:0002707)3.90552554
25immunoglobulin mediated immune response (GO:0016064)3.90229599
26regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.85835611
27response to peptidoglycan (GO:0032494)3.85640710
28mature B cell differentiation (GO:0002335)3.85370589
29antigen receptor-mediated signaling pathway (GO:0050851)3.83954345
30negative thymic T cell selection (GO:0045060)3.82653012
31B cell proliferation (GO:0042100)3.81353075
32negative regulation of interleukin-12 production (GO:0032695)3.74359618
33negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.71020415
34regulation of dendritic cell antigen processing and presentation (GO:0002604)3.70274270
35negative T cell selection (GO:0043383)3.66032129
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.58500468
37thymic T cell selection (GO:0045061)3.54669266
38negative regulation of T cell mediated immunity (GO:0002710)3.54534958
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.53860212
40negative regulation of leukocyte mediated immunity (GO:0002704)3.52899407
41detection of external biotic stimulus (GO:0098581)3.52615110
42T cell migration (GO:0072678)3.51184473
43tolerance induction (GO:0002507)3.50297760
44regulation of mast cell degranulation (GO:0043304)3.48764888
45T cell homeostasis (GO:0043029)3.46405741
46negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.45028926
47negative regulation of T-helper cell differentiation (GO:0045623)3.45028926
48respiratory burst (GO:0045730)3.39615666
49negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.38544981
50lymph node development (GO:0048535)3.37972255
51lymphocyte homeostasis (GO:0002260)3.36637011
52T cell selection (GO:0045058)3.35816017
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32257724
54Arp2/3 complex-mediated actin nucleation (GO:0034314)3.30684998
55positive T cell selection (GO:0043368)3.30153326
56regulation of T cell tolerance induction (GO:0002664)3.28021595
57negative regulation of B cell proliferation (GO:0030889)3.27718464
58NIK/NF-kappaB signaling (GO:0038061)3.25977946
59regulation of B cell proliferation (GO:0030888)3.25828486
60response to muramyl dipeptide (GO:0032495)3.25235321
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25164884
62response to host immune response (GO:0052572)3.25164884
63germinal center formation (GO:0002467)3.25152787
64immune response-activating cell surface receptor signaling pathway (GO:0002429)3.22330217
65neutrophil activation involved in immune response (GO:0002283)3.22197404
66positive regulation of antigen processing and presentation (GO:0002579)3.22018733
67mature B cell differentiation involved in immune response (GO:0002313)3.21514005
68ribosomal small subunit assembly (GO:0000028)3.21450241
69mast cell activation (GO:0045576)3.20913243
70regulation of alpha-beta T cell proliferation (GO:0046640)3.19808676
71regulation of mast cell activation involved in immune response (GO:0033006)3.19756546
72B cell homeostasis (GO:0001782)3.18703771
73negative regulation of alpha-beta T cell activation (GO:0046636)3.17653502
74production of molecular mediator involved in inflammatory response (GO:0002532)3.16973539
75regulation of T cell mediated cytotoxicity (GO:0001914)3.13911167
76positive regulation of mast cell activation (GO:0033005)3.13788283
77negative regulation of erythrocyte differentiation (GO:0045647)3.13626750
78interferon-gamma-mediated signaling pathway (GO:0060333)3.12963118
79* defense response to protozoan (GO:0042832)3.12617818
80regulation of T cell receptor signaling pathway (GO:0050856)3.11679157
81positive regulation of interferon-alpha production (GO:0032727)3.11036811
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09858563
83regulation of tolerance induction (GO:0002643)3.08924837
84detection of biotic stimulus (GO:0009595)3.08411864
85B cell mediated immunity (GO:0019724)3.06929912
86antigen processing and presentation via MHC class Ib (GO:0002475)3.06555710
87regulation of mast cell activation (GO:0033003)3.05694069
88regulation of myeloid leukocyte mediated immunity (GO:0002886)3.05576055
89regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.04958357
90regulation of natural killer cell mediated immunity (GO:0002715)3.04958357
91positive regulation of T cell mediated cytotoxicity (GO:0001916)3.04685216
92neutrophil activation (GO:0042119)3.03159593
93regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.02229551
94B cell activation (GO:0042113)3.02029451
95T cell costimulation (GO:0031295)3.01745736
96positive regulation of B cell activation (GO:0050871)3.01216434
97regulation of T-helper 2 cell differentiation (GO:0045628)3.00480487
98microglial cell activation (GO:0001774)3.00263311
99leukocyte homeostasis (GO:0001776)2.99513125
100regulation of interferon-alpha production (GO:0032647)2.98713056
101leukocyte degranulation (GO:0043299)2.98338428
102regulation of B cell apoptotic process (GO:0002902)2.98327780
103lymphocyte costimulation (GO:0031294)2.96302561
104response to host (GO:0075136)2.95371843
105response to host defenses (GO:0052200)2.95371843
106response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95371843
107positive regulation of type 2 immune response (GO:0002830)2.93736751
108negative regulation of innate immune response (GO:0045824)2.93335664
109cellular extravasation (GO:0045123)2.92089225
110positive regulation of B cell proliferation (GO:0030890)2.90530942
111regulation of B cell activation (GO:0050864)2.89548492
112positive regulation of granulocyte differentiation (GO:0030854)2.88428150
113mononuclear cell proliferation (GO:0032943)2.87188632
114positive regulation by symbiont of host defense response (GO:0052509)2.87150364
115modulation by symbiont of host defense response (GO:0052031)2.87150364
116modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87150364
117modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87150364
118positive regulation by organism of defense response of other organism involved in symbiotic interact2.87150364
119modulation by symbiont of host immune response (GO:0052553)2.87150364
120myeloid dendritic cell activation (GO:0001773)2.86452546
121positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86294775
122positive regulation of interleukin-2 production (GO:0032743)2.86113268
123macrophage activation involved in immune response (GO:0002281)2.85747929
124lymphocyte proliferation (GO:0046651)2.84842258
125response to type I interferon (GO:0034340)2.84457779
126T cell receptor signaling pathway (GO:0050852)2.83004095
127leukocyte cell-cell adhesion (GO:0007159)2.78358203
128cellular response to type I interferon (GO:0071357)2.78056059
129type I interferon signaling pathway (GO:0060337)2.78056059
130viral transcription (GO:0019083)2.76635870
131natural killer cell differentiation (GO:0001779)2.76568892
132interferon-gamma production (GO:0032609)2.75963807
133granulocyte activation (GO:0036230)2.75206013
134regulation of antigen processing and presentation (GO:0002577)2.74101257
135positive regulation of lamellipodium assembly (GO:0010592)2.72467567
136mast cell degranulation (GO:0043303)2.69431239
137mast cell activation involved in immune response (GO:0002279)2.69431239
138B cell differentiation (GO:0030183)2.68120134
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67564037
140JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.67072814
141myeloid cell activation involved in immune response (GO:0002275)2.66785554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human4.94536771
2E2F7_22180533_ChIP-Seq_HELA_Human4.58352752
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.00920444
4MYC_22102868_ChIP-Seq_BL_Human3.99417602
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.82140347
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.77077097
7* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.52408726
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.52223754
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.43408973
10VDR_21846776_ChIP-Seq_THP-1_Human3.22932168
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.82262111
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.71591109
13SCL_19346495_ChIP-Seq_HPC-7_Human2.61718382
14* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.59058751
15MYB_26560356_Chip-Seq_TH2_Human2.52517366
16MAF_26560356_Chip-Seq_TH1_Human2.49472527
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44868482
18RUNX_20019798_ChIP-Seq_JUKART_Human2.41347239
19* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.40363997
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.38220378
21MYB_26560356_Chip-Seq_TH1_Human2.35257417
22* SPI1_23547873_ChIP-Seq_NB4_Human2.34022028
23* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.33021231
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32504564
25VDR_24763502_ChIP-Seq_THP-1_Human2.29144361
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28862173
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27628747
28* UTX_26944678_Chip-Seq_JUKART_Human2.25876982
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22906383
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.17095138
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16421369
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.07003753
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.03560739
34TCF7_22412390_ChIP-Seq_EML_Mouse2.00997520
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.94777574
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94244567
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94073192
38CIITA_25753668_ChIP-Seq_RAJI_Human1.89266146
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86053995
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.85593684
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.84591578
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84516952
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82386343
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76660006
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74120129
46MAF_26560356_Chip-Seq_TH2_Human1.69449093
47SPI1_23127762_ChIP-Seq_K562_Human1.69083004
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68335051
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66679156
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49170093
51KDM2B_26808549_Chip-Seq_DND41_Human1.49079963
52GATA3_27048872_Chip-Seq_THYMUS_Human1.48209527
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47424658
54VDR_24787735_ChIP-Seq_THP-1_Human1.44044411
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42952257
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42527779
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41378859
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40714905
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40373443
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39571313
61GATA1_22025678_ChIP-Seq_K562_Human1.38444350
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36108564
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33611504
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.32626549
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30419390
66* ELK3_25401928_ChIP-Seq_HUVEC_Human1.29847128
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28421367
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28353255
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26108140
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25406481
71PU_27001747_Chip-Seq_BMDM_Mouse1.24724802
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22930877
73VDR_23849224_ChIP-Seq_CD4+_Human1.21480684
74BCOR_27268052_Chip-Seq_Bcells_Human1.21280406
75FOXP3_21729870_ChIP-Seq_TREG_Human1.21208987
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21206055
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20062332
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19231572
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17577282
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17120938
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16572550
82GATA1_19941826_ChIP-Seq_K562_Human1.11851154
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.11044033
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.09753357
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06742774
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05315335
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.04750137
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03789097
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03356569
90GATA3_26560356_Chip-Seq_TH2_Human1.02211029
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01713652
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01513316
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99358980
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98488984
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96509733
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95619764
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92705966
98* P300_27268052_Chip-Seq_Bcells_Human0.89646265
99XRN2_22483619_ChIP-Seq_HELA_Human0.88341905
100NCOR1_26117541_ChIP-Seq_K562_Human0.87359515
101FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87284604
102KDM5A_27292631_Chip-Seq_BREAST_Human0.86712814
103E2F1_21310950_ChIP-Seq_MCF-7_Human0.86635682
104MYC_18555785_ChIP-Seq_MESCs_Mouse0.85976481
105LXR_22292898_ChIP-Seq_THP-1_Human0.85773697
106SA1_27219007_Chip-Seq_ERYTHROID_Human0.85671299
107TFEB_21752829_ChIP-Seq_HELA_Human0.84554704
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84513081
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84269532
110CTCF_21964334_ChIP-Seq_BJAB-B_Human0.83679905
111P68_20966046_ChIP-Seq_HELA_Human0.83446578
112BCL6_27268052_Chip-Seq_Bcells_Human0.83405552
113RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83073891
114* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83053691
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77264287
116MYC_19079543_ChIP-ChIP_MESCs_Mouse0.77254920
117RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75750219
118SPI1_20517297_ChIP-Seq_HL60_Human0.75731863
119EST1_17652178_ChIP-ChIP_JURKAT_Human0.75535935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.92692225
2* MP0001800_abnormal_humoral_immune4.02148968
3MP0005387_immune_system_phenotype3.98819837
4MP0001790_abnormal_immune_system3.98819837
5MP0000685_abnormal_immune_system3.72859452
6MP0005671_abnormal_response_to3.45251184
7* MP0002452_abnormal_antigen_presenting3.28484841
8MP0005000_abnormal_immune_tolerance3.16319151
9MP0003303_peritoneal_inflammation3.02401646
10* MP0002723_abnormal_immune_serum2.96995374
11* MP0002420_abnormal_adaptive_immunity2.96500018
12MP0003763_abnormal_thymus_physiology2.94677993
13* MP0001819_abnormal_immune_cell2.90217181
14* MP0002398_abnormal_bone_marrow2.82366982
15MP0002396_abnormal_hematopoietic_system2.70807849
16MP0009785_altered_susceptibility_to2.63416709
17* MP0000716_abnormal_immune_system2.56425205
18MP0005025_abnormal_response_to2.54622648
19MP0003436_decreased_susceptibility_to2.53169540
20* MP0000689_abnormal_spleen_morphology2.47036001
21MP0002419_abnormal_innate_immunity2.38926314
22MP0002148_abnormal_hypersensitivity_rea2.24563586
23* MP0002722_abnormal_immune_system2.23008797
24MP0002166_altered_tumor_susceptibility2.21878299
25* MP0002429_abnormal_blood_cell2.15011695
26MP0002405_respiratory_system_inflammati2.10704028
27MP0001873_stomach_inflammation2.07962885
28MP0005464_abnormal_platelet_physiology2.01620720
29MP0009333_abnormal_splenocyte_physiolog1.98363713
30MP0004808_abnormal_hematopoietic_stem1.94413505
31MP0003300_gastrointestinal_ulcer1.92616616
32MP0010155_abnormal_intestine_physiology1.84107622
33MP0000703_abnormal_thymus_morphology1.81719325
34MP0001845_abnormal_inflammatory_respons1.78975016
35MP0001853_heart_inflammation1.78077011
36MP0004947_skin_inflammation1.67432004
37MP0002006_tumorigenesis1.65248120
38MP0006082_CNS_inflammation1.63763756
39MP0004510_myositis1.57819254
40MP0003866_abnormal_defecation1.47990375
41MP0005174_abnormal_tail_pigmentation1.46582150
42MP0000465_gastrointestinal_hemorrhage1.45982871
43MP0001545_abnormal_hematopoietic_system1.45907263
44MP0005397_hematopoietic_system_phenotyp1.45907263
45MP0002933_joint_inflammation1.45220274
46MP0002138_abnormal_hepatobiliary_system1.40966725
47MP0009278_abnormal_bone_marrow1.39645959
48MP0008057_abnormal_DNA_replication1.31578545
49MP0005310_abnormal_salivary_gland1.30457771
50MP0000490_abnormal_crypts_of1.29002483
51MP0003183_abnormal_peptide_metabolism1.26482649
52MP0003724_increased_susceptibility_to1.23410732
53MP0008469_abnormal_protein_level1.22758784
54MP0004381_abnormal_hair_follicle1.20536887
55MP0002019_abnormal_tumor_incidence1.18146880
56MP0008260_abnormal_autophagy1.18053712
57MP0003172_abnormal_lysosome_physiology1.15746323
58MP0001533_abnormal_skeleton_physiology1.13927985
59MP0010094_abnormal_chromosome_stability1.12569805
60MP0003077_abnormal_cell_cycle1.10304261
61MP0005058_abnormal_lysosome_morphology1.09367051
62MP0003191_abnormal_cellular_cholesterol1.06562583
63MP0001986_abnormal_taste_sensitivity1.01523182
64MP0005075_abnormal_melanosome_morpholog1.00623197
65MP0003693_abnormal_embryo_hatching0.96723785
66MP0000015_abnormal_ear_pigmentation0.93488551
67MP0005451_abnormal_body_composition0.93389768
68MP0000858_altered_metastatic_potential0.92498371
69MP0002277_abnormal_respiratory_mucosa0.91053291
70MP0010352_gastrointestinal_tract_polyps0.87712681
71MP0004883_abnormal_blood_vessel0.87521014
72MP0002095_abnormal_skin_pigmentation0.85517439
73MP0003075_altered_response_to0.84201569
74MP0002009_preneoplasia0.81705062
75MP0010307_abnormal_tumor_latency0.81099762
76MP0003448_altered_tumor_morphology0.80500733
77MP0006054_spinal_hemorrhage0.74962642
78MP0003111_abnormal_nucleus_morphology0.74219327
79MP0002136_abnormal_kidney_physiology0.73589549
80MP0008004_abnormal_stomach_pH0.72364347
81MP0009764_decreased_sensitivity_to0.69614287
82MP0001663_abnormal_digestive_system0.69031989
83MP0008007_abnormal_cellular_replicative0.68683886
84MP0000313_abnormal_cell_death0.67996500
85MP0005390_skeleton_phenotype0.67761095
86MP0008058_abnormal_DNA_repair0.66437303
87MP0001851_eye_inflammation0.66081219
88MP0003690_abnormal_glial_cell0.65033014
89MP0000249_abnormal_blood_vessel0.63980544
90MP0005166_decreased_susceptibility_to0.62123100
91MP0009763_increased_sensitivity_to0.61000790
92MP0009765_abnormal_xenobiotic_induced0.60888696
93MP0002928_abnormal_bile_duct0.60014652
94MP0003566_abnormal_cell_adhesion0.59923923
95MP0003806_abnormal_nucleotide_metabolis0.59862693
96MP0005023_abnormal_wound_healing0.59012416
97MP0004957_abnormal_blastocyst_morpholog0.58592890
98MP0000350_abnormal_cell_proliferation0.57588608
99MP0005076_abnormal_cell_differentiation0.57572185
100MP0002998_abnormal_bone_remodeling0.57128990
101MP0005381_digestive/alimentary_phenotyp0.55980882
102MP0002693_abnormal_pancreas_physiology0.55900097
103MP0003045_fibrosis0.54671704
104MP0008961_abnormal_basal_metabolism0.54140153
105MP0005164_abnormal_response_to0.53500964
106MP0009840_abnormal_foam_cell0.53480105
107MP0002132_abnormal_respiratory_system0.53365615
108MP0003795_abnormal_bone_structure0.53289386
109MP0003828_pulmonary_edema0.53027964
110MP0000343_altered_response_to0.52823901
111MP0000477_abnormal_intestine_morphology0.51193449
112MP0000371_diluted_coat_color0.50278526
113MP0000604_amyloidosis0.50157585
114MP0003091_abnormal_cell_migration0.49711062
115MP0003656_abnormal_erythrocyte_physiolo0.49131307
116MP0005621_abnormal_cell_physiology0.49118489
117MP0008874_decreased_physiological_sensi0.48707552
118MP0000569_abnormal_digit_pigmentation0.46618989
119MP0000598_abnormal_liver_morphology0.44205409
120MP0000609_abnormal_liver_physiology0.41313361
121MP0005535_abnormal_body_temperature0.40805507
122MP0009642_abnormal_blood_homeostasis0.40036181
123MP0005319_abnormal_enzyme/_coenzyme0.39619593
124MP0004130_abnormal_muscle_cell0.38999771
125MP0005084_abnormal_gallbladder_morpholo0.37081878

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)7.08658698
2Recurrent bronchitis (HP:0002837)5.68071357
3Gastrointestinal stroma tumor (HP:0100723)5.28642665
4IgM deficiency (HP:0002850)5.24108319
5Cellulitis (HP:0100658)5.21910017
6Recurrent viral infections (HP:0004429)4.70216239
7Recurrent abscess formation (HP:0002722)4.66298232
8Colitis (HP:0002583)4.57878378
9Panhypogammaglobulinemia (HP:0003139)4.52028455
10Recurrent sinusitis (HP:0011108)4.51178744
11Meningitis (HP:0001287)4.42400528
12Chronic otitis media (HP:0000389)4.35308611
13Inflammation of the large intestine (HP:0002037)4.34642748
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.31960192
15Verrucae (HP:0200043)4.29824700
16Papilloma (HP:0012740)4.29824700
17Orchitis (HP:0100796)4.24939957
18Gastrointestinal inflammation (HP:0004386)4.24088404
19Lymphopenia (HP:0001888)4.18897300
20Retrobulbar optic neuritis (HP:0100654)4.13921817
21Optic neuritis (HP:0100653)4.13921817
22Recurrent bacterial skin infections (HP:0005406)4.12851310
23Recurrent fungal infections (HP:0002841)4.05186184
24Abnormality of cells of the lymphoid lineage (HP:0012140)4.03573191
25Eczematoid dermatitis (HP:0000976)3.76435460
26Recurrent cutaneous fungal infections (HP:0011370)3.68110100
27Chronic mucocutaneous candidiasis (HP:0002728)3.68110100
28Thyroiditis (HP:0100646)3.64099783
29Vasculitis (HP:0002633)3.63794359
30Gastrointestinal infarctions (HP:0005244)3.62375894
31Chronic sinusitis (HP:0011109)3.61857314
32B lymphocytopenia (HP:0010976)3.61852924
33Abnormality of B cell number (HP:0010975)3.61852924
34Emphysema (HP:0002097)3.53721385
35Abnormality of T cells (HP:0002843)3.39119717
36T lymphocytopenia (HP:0005403)3.38946916
37Mediastinal lymphadenopathy (HP:0100721)3.36635379
38Recurrent skin infections (HP:0001581)3.34826792
39Osteomyelitis (HP:0002754)3.32922830
40Abnormality of T cell number (HP:0011839)3.28388994
41IgA deficiency (HP:0002720)3.25314602
42Thrombocytosis (HP:0001894)3.22355047
43Urticaria (HP:0001025)3.22236873
44Abnormality of T cell physiology (HP:0011840)3.21505254
45Elevated erythrocyte sedimentation rate (HP:0003565)3.20709113
46Bronchitis (HP:0012387)3.18535136
47IgG deficiency (HP:0004315)3.15114249
48Recurrent pneumonia (HP:0006532)3.14489909
49Recurrent lower respiratory tract infections (HP:0002783)3.05755789
50Abnormality of the fingertips (HP:0001211)3.05645715
51Nasal polyposis (HP:0100582)3.05237112
52Restrictive lung disease (HP:0002091)3.00554893
53Pustule (HP:0200039)2.98217966
54Keratoconjunctivitis sicca (HP:0001097)2.97190827
55Obstructive lung disease (HP:0006536)2.95295109
56Chronic obstructive pulmonary disease (HP:0006510)2.95295109
57Myositis (HP:0100614)2.94935092
58Autoimmune thrombocytopenia (HP:0001973)2.94582904
59Sepsis (HP:0100806)2.93872236
60Chronic diarrhea (HP:0002028)2.89405300
61Hemoptysis (HP:0002105)2.84505483
62Recurrent otitis media (HP:0000403)2.84288158
63Increased IgM level (HP:0003496)2.80204926
64Lymphoma (HP:0002665)2.79459504
65Keratoconjunctivitis (HP:0001096)2.78441013
66Combined immunodeficiency (HP:0005387)2.73408680
67Severe combined immunodeficiency (HP:0004430)2.72694644
68Hypochromic anemia (HP:0001931)2.72185647
69Hypochromic microcytic anemia (HP:0004840)2.67612073
70Abnormality of the nasal mucosa (HP:0000433)2.60738296
71Recurrent gram-negative bacterial infections (HP:0005420)2.55625683
72Pulmonary embolism (HP:0002204)2.52878467
73Prolonged bleeding time (HP:0003010)2.48546257
74Spontaneous hematomas (HP:0007420)2.46876472
75Abnormality of the prostate (HP:0008775)2.46713702
76Interstitial pulmonary disease (HP:0006530)2.45976536
77Petechiae (HP:0000967)2.43685173
78Abnormality of the pleura (HP:0002103)2.43495302
79Encephalitis (HP:0002383)2.41913607
80Leukopenia (HP:0001882)2.40788595
81Episodic fever (HP:0001954)2.38549839
82Eosinophilia (HP:0001880)2.33924866
83Purpura (HP:0000979)2.31735838
84Stomatitis (HP:0010280)2.31635677
85Skin ulcer (HP:0200042)2.31619810
86Autoimmune hemolytic anemia (HP:0001890)2.29429895
87Abnormality of macrophages (HP:0004311)2.28940825
88Increased IgE level (HP:0003212)2.28843136
89Small epiphyses (HP:0010585)2.26872529
90Anorexia (HP:0002039)2.26456069
91Abnormality of eosinophils (HP:0001879)2.24604505
92Skin rash (HP:0000988)2.24503436
93Pulmonary infiltrates (HP:0002113)2.23981404
94Leukocytosis (HP:0001974)2.20538707
95Granulocytopenia (HP:0001913)2.18782562
96Gangrene (HP:0100758)2.17459004
97Hypoplasia of the thymus (HP:0000778)2.15376667
98Periodontitis (HP:0000704)2.10706648
99Microcytic anemia (HP:0001935)2.08011602
100Viral hepatitis (HP:0006562)2.07341979
101Neutropenia (HP:0001875)2.07318336
102Mitral stenosis (HP:0001718)2.03850601
103Gingivitis (HP:0000230)2.01984504
104Chest pain (HP:0100749)2.01973435
105Abnormality of the peritoneum (HP:0002585)2.01144111
106Epistaxis (HP:0000421)1.99304011
107Papilledema (HP:0001085)1.99084806
108Hematochezia (HP:0002573)1.97790809
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94941254
110Basal cell carcinoma (HP:0002671)1.93041210
111Arthralgia (HP:0002829)1.92909938
112Glomerulopathy (HP:0100820)1.92830917
113Increased cerebral lipofuscin (HP:0011813)1.90301639
114Impaired platelet aggregation (HP:0003540)1.89617065
115Abnormal platelet function (HP:0011869)1.89617065
116Hypertensive crisis (HP:0100735)1.89568314
117Reticulocytopenia (HP:0001896)1.89428625
118Increased serum ferritin (HP:0003281)1.88406449
119Fatigue (HP:0012378)1.82201776
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80211051
121Vacuolated lymphocytes (HP:0001922)1.80202620
122Poikiloderma (HP:0001029)1.79991739
123Abnormality of cells of the erythroid lineage (HP:0012130)1.78089769
124Arterial thrombosis (HP:0004420)1.77525818
125Hypergammaglobulinemia (HP:0010702)1.74133815
126Gingival bleeding (HP:0000225)1.73921375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.44390452
2MAP3K103.14318667
3BLK3.02154729
4CSF1R2.77170328
5GRK62.77135224
6ERN12.72533168
7BTK2.61047496
8SYK2.43894327
9STK102.33020683
10TYK22.30143681
11PRPF4B2.21442738
12KIT2.21431480
13EEF2K2.08476408
14ZAP701.98534083
15RIPK41.92796130
16MAP3K141.91812926
17LRRK21.84809516
18TBK11.79935630
19IRAK41.78732264
20SIK21.78274435
21JAK31.75411207
22MAP3K131.74433905
23JAK11.71074138
24TXK1.66896236
25TEC1.64743741
26IKBKE1.61615684
27ITK1.54502714
28LYN1.53152726
29HCK1.48713735
30CLK11.43680442
31TGFBR21.43281986
32LCK1.39051720
33FES1.36311984
34CSK1.35545248
35IKBKB1.32299423
36BMPR21.25932146
37IRAK31.22055276
38TAOK11.15474930
39FGR1.12077342
40MAP2K31.11376593
41CDK121.10550296
42PIM11.10498023
43MARK31.09701873
44MAP3K31.06492610
45SIK31.03096524
46RPS6KA40.93025166
47PKN20.92632864
48FLT30.91505115
49TRIB30.90353287
50MAP3K10.89982449
51NEK20.88707158
52CDK190.88490038
53CDK40.87633755
54TNK20.86393616
55KDR0.82737661
56MST40.81877823
57MARK20.79872604
58TESK20.79415204
59EIF2AK30.78725621
60FGFR40.78336351
61MATK0.78286995
62FGFR30.77790514
63NLK0.77538491
64TAOK30.75762751
65CHUK0.75420735
66SMG10.74731453
67PRKCQ0.73594873
68PASK0.72608926
69CDC42BPA0.71011040
70NME20.70650184
71TAOK20.66766039
72STK40.64275584
73IRAK10.64090193
74SCYL20.63423065
75PRKCH0.61131550
76BRD40.56325498
77PIK3CG0.56054444
78YES10.56013104
79HIPK20.54952904
80PDPK10.53685152
81MAPK120.53222507
82IRAK20.51652388
83MAPK40.51451598
84MAP3K70.51376326
85JAK20.50760205
86STK110.49755925
87KSR20.49403038
88MAP2K20.49105777
89RPS6KB20.48669892
90CAMKK10.47827463
91ABL10.47427249
92MAPK110.47326173
93EPHB10.47308321
94PDK10.46875055
95SIK10.46318510
96ALK0.44737441
97GRK10.43487766
98MAP3K80.40424376
99DYRK1B0.39460664
100RPS6KA60.39215715
101PRKD20.38705766
102MAPKAPK20.38290654
103CDK90.38129846
104MAPK70.35817958
105ATR0.35631509
106FYN0.34667968
107CAMK1D0.34551508
108GRK70.32848307
109PIM20.32806800
110CDK60.31686919
111PTK2B0.29759003
112PRKCD0.29146906
113MELK0.29057728
114RPS6KL10.28892591
115RPS6KC10.28892591
116CDC70.28556397
117MAP2K60.27604666
118NEK90.25932092
119INSR0.25804806
120EGFR0.25653140
121PTK60.25386985
122MAP3K110.25184636
123TLK10.25087058
124CAMKK20.24913001
125TGFBR10.24492969
126MAPK30.23002985
127PRKD10.22454326
128MAP3K50.21991356

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.37809294
2B cell receptor signaling pathway_Homo sapiens_hsa046624.30040007
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.62376993
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.47158711
5* Hematopoietic cell lineage_Homo sapiens_hsa046402.45533381
6Leishmaniasis_Homo sapiens_hsa051402.40712001
7Antigen processing and presentation_Homo sapiens_hsa046122.35480267
8Osteoclast differentiation_Homo sapiens_hsa043802.23337775
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.16733518
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.99668116
11DNA replication_Homo sapiens_hsa030301.98494973
12Measles_Homo sapiens_hsa051621.97323620
13T cell receptor signaling pathway_Homo sapiens_hsa046601.92631571
14Base excision repair_Homo sapiens_hsa034101.80589699
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74530773
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73659552
17Herpes simplex infection_Homo sapiens_hsa051681.67028249
18Mismatch repair_Homo sapiens_hsa034301.65743958
19Ribosome_Homo sapiens_hsa030101.56117461
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55497754
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55140453
22Other glycan degradation_Homo sapiens_hsa005111.49833490
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48499925
24Rheumatoid arthritis_Homo sapiens_hsa053231.42179005
25Tuberculosis_Homo sapiens_hsa051521.40006126
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.39098237
27Chemokine signaling pathway_Homo sapiens_hsa040621.38231519
28Non-homologous end-joining_Homo sapiens_hsa034501.37282392
29Shigellosis_Homo sapiens_hsa051311.32436944
30Staphylococcus aureus infection_Homo sapiens_hsa051501.31784111
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31660639
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30310680
33Toxoplasmosis_Homo sapiens_hsa051451.28488313
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.27341847
35Epstein-Barr virus infection_Homo sapiens_hsa051691.22615242
36Acute myeloid leukemia_Homo sapiens_hsa052211.22287157
37Influenza A_Homo sapiens_hsa051641.21754708
38Allograft rejection_Homo sapiens_hsa053301.20140642
39Hepatitis B_Homo sapiens_hsa051611.18517242
40Apoptosis_Homo sapiens_hsa042101.15398780
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15218408
42Platelet activation_Homo sapiens_hsa046111.14729612
43Pertussis_Homo sapiens_hsa051331.14013040
44Phagosome_Homo sapiens_hsa041451.10095278
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.09446043
46Viral myocarditis_Homo sapiens_hsa054161.07709743
47Chronic myeloid leukemia_Homo sapiens_hsa052201.06294947
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02478994
49Malaria_Homo sapiens_hsa051441.01877596
50Legionellosis_Homo sapiens_hsa051341.01300427
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01099864
52Homologous recombination_Homo sapiens_hsa034400.99870015
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98792908
54Spliceosome_Homo sapiens_hsa030400.96057805
55Pancreatic cancer_Homo sapiens_hsa052120.95771443
56Asthma_Homo sapiens_hsa053100.92544221
57Non-small cell lung cancer_Homo sapiens_hsa052230.91536846
58Graft-versus-host disease_Homo sapiens_hsa053320.90611206
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87499955
60TNF signaling pathway_Homo sapiens_hsa046680.86717675
61HTLV-I infection_Homo sapiens_hsa051660.84130153
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.84104327
63Viral carcinogenesis_Homo sapiens_hsa052030.83719321
64Salmonella infection_Homo sapiens_hsa051320.80082284
65Nucleotide excision repair_Homo sapiens_hsa034200.77938741
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71425328
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69646613
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67841059
69Hepatitis C_Homo sapiens_hsa051600.67007115
70Lysosome_Homo sapiens_hsa041420.64913558
71VEGF signaling pathway_Homo sapiens_hsa043700.63280507
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62815573
73p53 signaling pathway_Homo sapiens_hsa041150.62372931
74Small cell lung cancer_Homo sapiens_hsa052220.57900041
75Colorectal cancer_Homo sapiens_hsa052100.57655997
76African trypanosomiasis_Homo sapiens_hsa051430.57405748
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54452062
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54164390
79Notch signaling pathway_Homo sapiens_hsa043300.53412347
80Fanconi anemia pathway_Homo sapiens_hsa034600.49223369
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48528856
82Cell cycle_Homo sapiens_hsa041100.48292004
83Autoimmune thyroid disease_Homo sapiens_hsa053200.46815665
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.45570455
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.44755385
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44257509
87RNA degradation_Homo sapiens_hsa030180.43892461
88Choline metabolism in cancer_Homo sapiens_hsa052310.43793496
89Pyrimidine metabolism_Homo sapiens_hsa002400.41294220
90Endocytosis_Homo sapiens_hsa041440.40817604
91Prolactin signaling pathway_Homo sapiens_hsa049170.40429051
92Renal cell carcinoma_Homo sapiens_hsa052110.40073413
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39419543
94Caffeine metabolism_Homo sapiens_hsa002320.38290818
95FoxO signaling pathway_Homo sapiens_hsa040680.36805187
96Inositol phosphate metabolism_Homo sapiens_hsa005620.35179604
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.34710806
98N-Glycan biosynthesis_Homo sapiens_hsa005100.33517641
99MAPK signaling pathway_Homo sapiens_hsa040100.33396360
100Pentose phosphate pathway_Homo sapiens_hsa000300.33355610
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32260841
102Systemic lupus erythematosus_Homo sapiens_hsa053220.31234953
103Insulin resistance_Homo sapiens_hsa049310.31038289
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.30764000
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30148787
106Regulation of autophagy_Homo sapiens_hsa041400.29942906
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28968201
108RNA transport_Homo sapiens_hsa030130.28890653
109MicroRNAs in cancer_Homo sapiens_hsa052060.28154310
110HIF-1 signaling pathway_Homo sapiens_hsa040660.27574756
111GnRH signaling pathway_Homo sapiens_hsa049120.27217135
112Lysine degradation_Homo sapiens_hsa003100.27035377
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26956804
114mTOR signaling pathway_Homo sapiens_hsa041500.26855255
115mRNA surveillance pathway_Homo sapiens_hsa030150.26178221
116Dorso-ventral axis formation_Homo sapiens_hsa043200.24043930
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23805087
118Endometrial cancer_Homo sapiens_hsa052130.23153523
119Type I diabetes mellitus_Homo sapiens_hsa049400.23058764
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20791508
121Rap1 signaling pathway_Homo sapiens_hsa040150.16791751
122Arachidonic acid metabolism_Homo sapiens_hsa005900.16296762
123Prostate cancer_Homo sapiens_hsa052150.15045935
124Type II diabetes mellitus_Homo sapiens_hsa049300.14933012
125Ras signaling pathway_Homo sapiens_hsa040140.12552457
126Amoebiasis_Homo sapiens_hsa051460.12195754

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