CD38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.85170556
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.85170556
3modulation by symbiont of host immune response (GO:0052553)4.85170556
4positive regulation by symbiont of host defense response (GO:0052509)4.85170556
5modulation by symbiont of host defense response (GO:0052031)4.85170556
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.85170556
7regulation of interferon-beta biosynthetic process (GO:0045357)4.67769392
8positive regulation of interferon-alpha production (GO:0032727)4.57482442
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.38562806
10regulation of interferon-alpha production (GO:0032647)4.36005104
11response to peptidoglycan (GO:0032494)4.22284621
12macrophage activation involved in immune response (GO:0002281)4.16555327
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.14978108
14lipopolysaccharide-mediated signaling pathway (GO:0031663)4.10458516
15neutrophil activation involved in immune response (GO:0002283)4.09690143
16negative regulation of cell killing (GO:0031342)4.00712761
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00712761
18positive regulation of B cell differentiation (GO:0045579)3.96291463
19regulation of T-helper 1 cell differentiation (GO:0045625)3.86582638
20regulation of gamma-delta T cell differentiation (GO:0045586)3.80543718
21negative thymic T cell selection (GO:0045060)3.78835639
22regulation of B cell receptor signaling pathway (GO:0050855)3.76859042
23positive regulation of gamma-delta T cell activation (GO:0046645)3.73945271
24negative T cell selection (GO:0043383)3.71596471
25antigen processing and presentation of endogenous antigen (GO:0019883)3.70772847
26positive regulation of chemokine biosynthetic process (GO:0045080)3.70621953
27negative regulation of interleukin-12 production (GO:0032695)3.65967148
28B cell mediated immunity (GO:0019724)3.65940712
29regulation of antigen processing and presentation (GO:0002577)3.60531392
30positive regulation of cellular amide metabolic process (GO:0034250)3.59128077
31macrophage activation (GO:0042116)3.56804703
32natural killer cell activation involved in immune response (GO:0002323)3.56496402
33regulation of MHC class I biosynthetic process (GO:0045343)3.56178125
34production of molecular mediator involved in inflammatory response (GO:0002532)3.55954492
35negative regulation of viral genome replication (GO:0045071)3.54339424
36positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.51963726
37cellular response to exogenous dsRNA (GO:0071360)3.50233837
38granulocyte activation (GO:0036230)3.48791878
39negative regulation of T cell mediated immunity (GO:0002710)3.42356926
40regulation of tolerance induction (GO:0002643)3.40096806
41T cell migration (GO:0072678)3.37353012
42regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.36327295
43regulation of B cell differentiation (GO:0045577)3.35346580
44positive thymic T cell selection (GO:0045059)3.35217611
45neutrophil activation (GO:0042119)3.34956787
46positive regulation of granulocyte differentiation (GO:0030854)3.32430938
47regulation of type I interferon-mediated signaling pathway (GO:0060338)3.30321295
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.29491478
49positive regulation of mast cell activation involved in immune response (GO:0033008)3.29041591
50positive regulation of mast cell degranulation (GO:0043306)3.29041591
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28690446
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28690446
53germinal center formation (GO:0002467)3.27604213
54lymph vessel development (GO:0001945)3.27303834
55respiratory burst (GO:0045730)3.26821939
56positive regulation of defense response to virus by host (GO:0002230)3.25720359
57microglial cell activation (GO:0001774)3.24372624
58positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.23561098
59response to interleukin-15 (GO:0070672)3.22848561
60positive regulation of tolerance induction (GO:0002645)3.22815294
61cellular response to interleukin-15 (GO:0071350)3.22380697
62regulation of T cell tolerance induction (GO:0002664)3.22137201
63immunoglobulin mediated immune response (GO:0016064)3.21277750
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.19374105
65response to host immune response (GO:0052572)3.19374105
66response to type I interferon (GO:0034340)3.18438018
67positive regulation of monocyte chemotaxis (GO:0090026)3.17710294
68superoxide anion generation (GO:0042554)3.16702734
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15805098
70regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.14485684
71detection of molecule of bacterial origin (GO:0032490)3.14022943
72Peyers patch development (GO:0048541)3.13024972
73mucosal-associated lymphoid tissue development (GO:0048537)3.13024972
74interferon-gamma-mediated signaling pathway (GO:0060333)3.12984802
75T-helper 1 type immune response (GO:0042088)3.12091611
76cellular response to type I interferon (GO:0071357)3.11430293
77type I interferon signaling pathway (GO:0060337)3.11430293
78detection of bacterium (GO:0016045)3.11014720
79regulation of chemokine biosynthetic process (GO:0045073)3.10811956
80* B cell receptor signaling pathway (GO:0050853)3.10684070
81positive regulation of interferon-beta production (GO:0032728)3.10314838
82I-kappaB phosphorylation (GO:0007252)3.08081354
83T cell selection (GO:0045058)3.03413438
84positive regulation of interleukin-1 secretion (GO:0050716)3.02414337
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02259215
86response to host (GO:0075136)3.02259215
87response to host defenses (GO:0052200)3.02259215
88myeloid dendritic cell activation (GO:0001773)3.01973011
89mast cell activation (GO:0045576)3.01499113
90positive regulation of antigen processing and presentation (GO:0002579)3.01195566
91defense response to protozoan (GO:0042832)3.00232936
92cellular response to interferon-beta (GO:0035458)2.99987112
93interferon-gamma production (GO:0032609)2.99406706
94lymphocyte chemotaxis (GO:0048247)2.99207737
95regulation of T-helper cell differentiation (GO:0045622)2.98632442
96positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97989237
97regulation of interleukin-12 production (GO:0032655)2.97463174
98negative regulation of lymphocyte mediated immunity (GO:0002707)2.97113964
99regulation of interleukin-2 biosynthetic process (GO:0045076)2.96445825
100cellular extravasation (GO:0045123)2.96406960
101hydrogen peroxide biosynthetic process (GO:0050665)2.95708277
102thymic T cell selection (GO:0045061)2.94112973
103positive T cell selection (GO:0043368)2.93780126
104regulation of germinal center formation (GO:0002634)2.92991950
105myeloid cell activation involved in immune response (GO:0002275)2.92187358
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90136885
107regulation of superoxide anion generation (GO:0032928)2.89749717
108response to interferon-gamma (GO:0034341)2.89250073
109defense response to virus (GO:0051607)2.89223002
110tolerance induction (GO:0002507)2.88762096
111positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.88404141
112modulation of growth of symbiont involved in interaction with host (GO:0044144)2.87798866
113regulation of growth of symbiont in host (GO:0044126)2.87798866
114negative regulation of growth of symbiont in host (GO:0044130)2.87798866
115negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.87798866
116T cell activation involved in immune response (GO:0002286)2.87508558
117mature B cell differentiation involved in immune response (GO:0002313)2.85867121
118regulation of alpha-beta T cell activation (GO:0046634)2.84655911
119positive regulation of interleukin-2 production (GO:0032743)2.83641226
120regulation of fever generation (GO:0031620)2.82666566
121regulation of interleukin-12 biosynthetic process (GO:0045075)2.82480878
122regulation of mast cell degranulation (GO:0043304)2.82272638
123positive regulation of interleukin-12 production (GO:0032735)2.80666133
124regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80195850
125positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.79521615
126positive regulation of mast cell activation (GO:0033005)2.75627350
127response to muramyl dipeptide (GO:0032495)2.74640793
128response to interferon-beta (GO:0035456)2.73921037
129regulation of monocyte chemotaxis (GO:0090025)2.72703980
130regulation of activation of Janus kinase activity (GO:0010533)2.72235159
131regulation of alpha-beta T cell proliferation (GO:0046640)2.71995500
132positive regulation of macrophage differentiation (GO:0045651)2.71029220
133positive regulation of type 2 immune response (GO:0002830)2.70234110
134regulation of platelet activation (GO:0010543)2.68671753
135positive regulation of heat generation (GO:0031652)2.68632789
136positive regulation of chemokine production (GO:0032722)2.68090574
137cellular response to interferon-gamma (GO:0071346)2.67820799
138response to protozoan (GO:0001562)2.67464404
139detection of other organism (GO:0098543)2.67141882
140regulation of gamma-delta T cell activation (GO:0046643)2.66513990
141eosinophil chemotaxis (GO:0048245)2.65230790
142low-density lipoprotein particle remodeling (GO:0034374)2.64736920
143B cell proliferation (GO:0042100)2.64513945
144detection of external biotic stimulus (GO:0098581)2.63699579
145regulation of mast cell activation involved in immune response (GO:0033006)2.62605104
146positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.62427421
147positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.62165803
148leukocyte cell-cell adhesion (GO:0007159)2.62076385
149positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.61561033
150positive regulation of tumor necrosis factor production (GO:0032760)2.61369303
151cytokine secretion (GO:0050663)2.61274104
152regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.61082965
153leukocyte tethering or rolling (GO:0050901)2.60319743
154positive regulation of interleukin-1 beta secretion (GO:0050718)2.59658946
155neutrophil chemotaxis (GO:0030593)2.59329361
156myeloid leukocyte activation (GO:0002274)2.58997507
157positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.58497126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.59041595
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.12651880
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.99537895
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.22890738
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.02336495
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.73863054
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.67053199
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32150341
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.04761583
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.77314047
11* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75214953
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70746618
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.68717430
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.64794051
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.54831423
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48747311
17* RUNX_20019798_ChIP-Seq_JUKART_Human2.42847339
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37264635
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.24521350
20MYC_22102868_ChIP-Seq_BL_Human2.23044255
21VDR_21846776_ChIP-Seq_THP-1_Human2.16839830
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.16426937
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.08498851
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98901290
25CDX2_20551321_ChIP-Seq_CACO-2_Human1.92206693
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84184567
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80973542
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.77059153
29* VDR_24787735_ChIP-Seq_THP-1_Human1.75260733
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.72685906
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.72446505
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63193991
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62941385
34MAF_26560356_Chip-Seq_TH2_Human1.55499453
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55306557
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53871231
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52172615
38* MYB_26560356_Chip-Seq_TH2_Human1.51696960
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.50734439
40SCL_19346495_ChIP-Seq_HPC-7_Human1.47904691
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46643757
42SPI1_23547873_ChIP-Seq_NB4_Human1.44704537
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44697571
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41715032
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.39996581
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35288120
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34994379
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.34194064
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33678078
50* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33120633
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30119942
52SPI1_23127762_ChIP-Seq_K562_Human1.29065236
53PU_27001747_Chip-Seq_BMDM_Mouse1.28591146
54CIITA_25753668_ChIP-Seq_RAJI_Human1.26431613
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26048325
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23726124
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.23184228
58* GATA1_19941827_ChIP-Seq_MEL_Mouse1.23074068
59MYB_26560356_Chip-Seq_TH1_Human1.21448283
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21152810
61* VDR_24763502_ChIP-Seq_THP-1_Human1.20539054
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18477471
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.14800012
64MAF_26560356_Chip-Seq_TH1_Human1.14033772
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13101957
66SOX2_20726797_ChIP-Seq_SW620_Human1.13075530
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11519529
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10632715
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.10242611
70TCF7_22412390_ChIP-Seq_EML_Mouse1.10178365
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10033276
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09004096
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06116242
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04425290
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04073708
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03257563
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02760926
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01210729
79SMRT_27268052_Chip-Seq_Bcells_Human1.00748260
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99827353
81GATA1_22025678_ChIP-Seq_K562_Human0.99778281
82NOTCH1_21737748_ChIP-Seq_TLL_Human0.98597932
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97794442
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97706651
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91926604
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91759410
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90327087
88GATA2_19941826_ChIP-Seq_K562_Human0.89915275
89* KDM2B_26808549_Chip-Seq_DND41_Human0.89615902
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88734505
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88582823
92CJUN_26792858_Chip-Seq_BT549_Human0.88089741
93* GATA3_27048872_Chip-Seq_THYMUS_Human0.87043104
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86815693
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86519157
96STAT1_20625510_ChIP-Seq_HELA_Human0.86376904
97SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85584143
98* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85070068
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84858504
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84836660
101BCL6_27268052_Chip-Seq_Bcells_Human0.84481819
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83901560
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83790755
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83468501
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81946106
106PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81665863
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81659178
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81522602
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81522602
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81215736
111GATA1_19941826_ChIP-Seq_K562_Human0.80844671
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80205960
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79905417
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78514494
115GATA3_26560356_Chip-Seq_TH1_Human0.78504458
116GATA3_26560356_Chip-Seq_TH2_Human0.78295557
117CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.77872426
118SPI1_20517297_ChIP-Seq_HL60_Human0.76545452
119CLOCK_20551151_ChIP-Seq_293T_Human0.76409977
120UTX_26944678_Chip-Seq_JUKART_Human0.75523629
121RXR_22108803_ChIP-Seq_LS180_Human0.75172618
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.74942366
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.74777158
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74202224
125P300_27268052_Chip-Seq_Bcells_Human0.74073742
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74073018
127BCOR_27268052_Chip-Seq_Bcells_Human0.73780417
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.73481937
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.73241417
130SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.73241417
131KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72846458
132SOX2_27498859_Chip-Seq_STOMACH_Mouse0.72041805
133BCAT_22108803_ChIP-Seq_LS180_Human0.71647486
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71508561
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71360610
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70210231
137RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68253768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.27259295
2MP0001835_abnormal_antigen_presentation4.21702359
3MP0009785_altered_susceptibility_to3.40497595
4MP0002148_abnormal_hypersensitivity_rea3.14273397
5MP0005387_immune_system_phenotype3.01639423
6MP0001790_abnormal_immune_system3.01639423
7* MP0001800_abnormal_humoral_immune2.90742701
8* MP0005000_abnormal_immune_tolerance2.81898837
9MP0002419_abnormal_innate_immunity2.75317229
10MP0005167_abnormal_blood-brain_barrier2.75036865
11MP0003436_decreased_susceptibility_to2.73624286
12MP0001879_abnormal_lymphatic_vessel2.73208437
13MP0002452_abnormal_antigen_presenting2.71689725
14MP0005025_abnormal_response_to2.67890871
15MP0005671_abnormal_response_to2.66709953
16MP0003303_peritoneal_inflammation2.63307671
17MP0010368_abnormal_lymphatic_system2.50859359
18MP0006082_CNS_inflammation2.45723642
19MP0002723_abnormal_immune_serum2.41323473
20MP0000685_abnormal_immune_system2.33564077
21MP0009764_decreased_sensitivity_to2.24159762
22* MP0001819_abnormal_immune_cell2.18994749
23* MP0002420_abnormal_adaptive_immunity2.18200136
24MP0006054_spinal_hemorrhage2.14598964
25MP0010155_abnormal_intestine_physiology2.04813158
26MP0003828_pulmonary_edema1.84198470
27MP0004947_skin_inflammation1.77367202
28MP0003075_altered_response_to1.75561070
29MP0001533_abnormal_skeleton_physiology1.75425720
30MP0003300_gastrointestinal_ulcer1.75050821
31MP0005464_abnormal_platelet_physiology1.74514102
32MP0001873_stomach_inflammation1.70075916
33* MP0001845_abnormal_inflammatory_respons1.69237315
34MP0002006_tumorigenesis1.68995954
35MP0003690_abnormal_glial_cell1.68930701
36MP0001853_heart_inflammation1.68656598
37MP0005058_abnormal_lysosome_morphology1.62912380
38MP0005451_abnormal_body_composition1.61886775
39MP0005166_decreased_susceptibility_to1.60031759
40MP0003191_abnormal_cellular_cholesterol1.59313864
41MP0002405_respiratory_system_inflammati1.55625524
42MP0008469_abnormal_protein_level1.53582143
43MP0000703_abnormal_thymus_morphology1.52525786
44MP0000716_abnormal_immune_system1.51540415
45MP0003172_abnormal_lysosome_physiology1.47084500
46MP0000343_altered_response_to1.45515239
47MP0002398_abnormal_bone_marrow1.43605779
48MP0005360_urolithiasis1.34556452
49MP0002277_abnormal_respiratory_mucosa1.34257322
50MP0003646_muscle_fatigue1.34184741
51MP0002166_altered_tumor_susceptibility1.34104262
52MP0000689_abnormal_spleen_morphology1.32385981
53MP0000249_abnormal_blood_vessel1.29569307
54MP0003448_altered_tumor_morphology1.28711670
55MP0002138_abnormal_hepatobiliary_system1.28387863
56MP0004808_abnormal_hematopoietic_stem1.26534520
57MP0005164_abnormal_response_to1.25769502
58MP0009278_abnormal_bone_marrow1.24861241
59MP0004510_myositis1.24711788
60MP0002429_abnormal_blood_cell1.20557423
61MP0003656_abnormal_erythrocyte_physiolo1.19474435
62MP0000465_gastrointestinal_hemorrhage1.17903866
63MP0003866_abnormal_defecation1.17746685
64MP0010234_abnormal_vibrissa_follicle1.15556796
65MP0008004_abnormal_stomach_pH1.15515112
66MP0002998_abnormal_bone_remodeling1.13788159
67MP0005310_abnormal_salivary_gland1.12566985
68MP0002722_abnormal_immune_system1.10400811
69MP0003183_abnormal_peptide_metabolism1.10294084
70MP0003763_abnormal_thymus_physiology1.07539966
71MP0001851_eye_inflammation1.07146498
72MP0002933_joint_inflammation1.04683250
73MP0002254_reproductive_system_inflammat1.04483577
74MP0009333_abnormal_splenocyte_physiolog1.04261508
75MP0005670_abnormal_white_adipose1.03860080
76MP0000767_abnormal_smooth_muscle1.03191390
77MP0003045_fibrosis1.01675695
78MP0000858_altered_metastatic_potential0.98264840
79MP0005075_abnormal_melanosome_morpholog0.97591102
80MP0003806_abnormal_nucleotide_metabolis0.97322483
81MP0004782_abnormal_surfactant_physiolog0.95971772
82MP0009763_increased_sensitivity_to0.93365157
83MP0005377_hearing/vestibular/ear_phenot0.91438348
84MP0003878_abnormal_ear_physiology0.91438348
85MP0002009_preneoplasia0.90165602
86MP0001663_abnormal_digestive_system0.89660497
87MP0002136_abnormal_kidney_physiology0.89484062
88MP0003279_aneurysm0.87731797
89MP0004883_abnormal_blood_vessel0.85944119
90MP0003453_abnormal_keratinocyte_physiol0.83619162
91MP0010352_gastrointestinal_tract_polyps0.82906230
92MP0002332_abnormal_exercise_endurance0.81810022
93MP0004381_abnormal_hair_follicle0.81365934
94MP0008057_abnormal_DNA_replication0.81157418
95MP0009765_abnormal_xenobiotic_induced0.79719573
96MP0005171_absent_coat_pigmentation0.77726979
97MP0002396_abnormal_hematopoietic_system0.76179069
98MP0005390_skeleton_phenotype0.74299396
99MP0002019_abnormal_tumor_incidence0.73435999
100MP0000604_amyloidosis0.72605423
101MP0005165_increased_susceptibility_to0.72217909
102MP0009840_abnormal_foam_cell0.72162316
103MP0000015_abnormal_ear_pigmentation0.72026538
104MP0000569_abnormal_digit_pigmentation0.71412886
105MP0004147_increased_porphyrin_level0.70214530
106MP0005266_abnormal_metabolism0.68042472
107MP0009643_abnormal_urine_homeostasis0.65749603
108MP0002132_abnormal_respiratory_system0.63568213
109MP0000490_abnormal_crypts_of0.63436806
110MP0003186_abnormal_redox_activity0.62760670
111MP0000609_abnormal_liver_physiology0.62162605
112MP0005397_hematopoietic_system_phenotyp0.60804197
113MP0001545_abnormal_hematopoietic_system0.60804197
114MP0005319_abnormal_enzyme/_coenzyme0.60025540
115MP0008874_decreased_physiological_sensi0.55524737
116MP0005076_abnormal_cell_differentiation0.55189570
117MP0003566_abnormal_cell_adhesion0.54944106
118MP0005085_abnormal_gallbladder_physiolo0.54812172
119MP0002163_abnormal_gland_morphology0.52975403
120* MP0002693_abnormal_pancreas_physiology0.52547435
121MP0002139_abnormal_hepatobiliary_system0.52490956
122MP0005535_abnormal_body_temperature0.48314409
123MP0006036_abnormal_mitochondrial_physio0.47525384
124MP0005376_homeostasis/metabolism_phenot0.47356438
125MP0001501_abnormal_sleep_pattern0.46321833

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.71887417
2Recurrent bacterial skin infections (HP:0005406)5.23341640
3Eczematoid dermatitis (HP:0000976)5.05581949
4Recurrent gram-negative bacterial infections (HP:0005420)4.57969116
5Agammaglobulinemia (HP:0004432)4.54042304
6Pustule (HP:0200039)4.30275252
7Autoimmune thrombocytopenia (HP:0001973)4.22449287
8Systemic lupus erythematosus (HP:0002725)4.01012737
9Recurrent viral infections (HP:0004429)3.81300183
10Spontaneous hematomas (HP:0007420)3.80892134
11Mediastinal lymphadenopathy (HP:0100721)3.80253175
12Colitis (HP:0002583)3.80007180
13Myositis (HP:0100614)3.73058198
14Cellulitis (HP:0100658)3.72640086
15Vasculitis (HP:0002633)3.60089362
16Gastrointestinal stroma tumor (HP:0100723)3.55179667
17Orchitis (HP:0100796)3.54126191
18Granulocytopenia (HP:0001913)3.48613225
19Meningitis (HP:0001287)3.48144487
20Recurrent skin infections (HP:0001581)3.48035765
21Recurrent fungal infections (HP:0002841)3.46063159
22Optic neuritis (HP:0100653)3.41861162
23Retrobulbar optic neuritis (HP:0100654)3.41861162
24Hematochezia (HP:0002573)3.35463219
25Inflammation of the large intestine (HP:0002037)3.34812510
26Severe combined immunodeficiency (HP:0004430)3.26400127
27Abnormality of macrophages (HP:0004311)3.21723436
28Vacuolated lymphocytes (HP:0001922)3.21288068
29Gingivitis (HP:0000230)3.15109300
30Glomerulonephritis (HP:0000099)3.13186135
31Prostate neoplasm (HP:0100787)3.06823462
32IgG deficiency (HP:0004315)3.05596620
33Gastrointestinal inflammation (HP:0004386)3.05521569
34Chronic diarrhea (HP:0002028)3.05512752
35Recurrent pneumonia (HP:0006532)3.05018055
36Nasal polyposis (HP:0100582)2.99331379
37Thick nail (HP:0001805)2.93962731
38Osteomyelitis (HP:0002754)2.93807958
39Abnormality of eosinophils (HP:0001879)2.93675793
40Pulmonary infiltrates (HP:0002113)2.88042177
41Recurrent sinusitis (HP:0011108)2.87261335
42Stomatitis (HP:0010280)2.83829234
43Periodontitis (HP:0000704)2.83169612
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.81444662
45Gastrointestinal infarctions (HP:0005244)2.80156123
46Bronchitis (HP:0012387)2.79916786
47Panhypogammaglobulinemia (HP:0003139)2.77636122
48Recurrent lower respiratory tract infections (HP:0002783)2.72899498
49Chronic obstructive pulmonary disease (HP:0006510)2.72892261
50Obstructive lung disease (HP:0006536)2.72892261
51Recurrent bronchitis (HP:0002837)2.72362073
52Hypergammaglobulinemia (HP:0010702)2.70673829
53Recurrent cutaneous fungal infections (HP:0011370)2.69883506
54Chronic mucocutaneous candidiasis (HP:0002728)2.69883506
55Elevated erythrocyte sedimentation rate (HP:0003565)2.66382085
56Increased IgE level (HP:0003212)2.64283032
57Abnormality of the prostate (HP:0008775)2.63581572
58Lymphopenia (HP:0001888)2.61122917
59Thyroiditis (HP:0100646)2.60893550
60Sepsis (HP:0100806)2.59691449
61Joint hemorrhage (HP:0005261)2.58954997
62Chest pain (HP:0100749)2.58177633
63Urticaria (HP:0001025)2.57621607
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.54346263
65Bronchiectasis (HP:0002110)2.52505730
66Dynein arm defect of respiratory motile cilia (HP:0012255)2.51994585
67Absent/shortened dynein arms (HP:0200106)2.51994585
68Keratoconjunctivitis sicca (HP:0001097)2.50149916
69Tetraparesis (HP:0002273)2.48939839
70Abnormality of the axillary hair (HP:0100134)2.46790543
71Abnormality of secondary sexual hair (HP:0009888)2.46790543
72Arterial thrombosis (HP:0004420)2.41354350
73Esophageal varix (HP:0002040)2.38196335
74Hypoplasia of the thymus (HP:0000778)2.38147182
75Emphysema (HP:0002097)2.37567011
76Acute lymphatic leukemia (HP:0006721)2.37529198
77Gangrene (HP:0100758)2.37462254
78Alopecia of scalp (HP:0002293)2.36375731
79Chronic otitis media (HP:0000389)2.35705454
80Abnormality of the pleura (HP:0002103)2.35385153
81Complement deficiency (HP:0004431)2.34392115
82Interstitial pulmonary disease (HP:0006530)2.34118284
83Premature loss of primary teeth (HP:0006323)2.30908041
84Myocardial infarction (HP:0001658)2.30520096
85Basal ganglia calcification (HP:0002135)2.29696403
86Hemoptysis (HP:0002105)2.29557865
87B lymphocytopenia (HP:0010976)2.28480099
88Abnormality of B cell number (HP:0010975)2.28480099
89Lymphoma (HP:0002665)2.24908439
90Keratoconjunctivitis (HP:0001096)2.24614450
91Abnormality of complement system (HP:0005339)2.23581986
92Abnormality of liposaccharide metabolism (HP:0010968)2.22975760
93Abnormality of glycosphingolipid metabolism (HP:0004343)2.22975760
94Abnormality of glycolipid metabolism (HP:0010969)2.22975760
95Nephritis (HP:0000123)2.22935121
96Nonimmune hydrops fetalis (HP:0001790)2.22786953
97Abnormality of T cell number (HP:0011839)2.21748497
98Encephalitis (HP:0002383)2.19589484
99Abnormality of T cell physiology (HP:0011840)2.19027803
100Joint swelling (HP:0001386)2.18649195
101IgM deficiency (HP:0002850)2.17594742
102IgA deficiency (HP:0002720)2.15694179
103Pulmonary embolism (HP:0002204)2.12307212
104Eosinophilia (HP:0001880)2.12186249
105Skin rash (HP:0000988)2.11723081
106Increased IgM level (HP:0003496)2.11429295
107Abnormality of T cells (HP:0002843)2.10884025
108Prolonged bleeding time (HP:0003010)2.10346874
109Abnormal respiratory motile cilium morphology (HP:0005938)2.10233375
110Abnormal respiratory epithelium morphology (HP:0012253)2.10233375
111Blepharitis (HP:0000498)2.09626888
112Polycythemia (HP:0001901)2.08900874
113Leukocytosis (HP:0001974)2.08668419
114Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08281028
115Restrictive lung disease (HP:0002091)2.08107640
116Aplasia/Hypoplasia of the thymus (HP:0010515)2.07738813
117Acute hepatic failure (HP:0006554)2.06402377
118Purpura (HP:0000979)2.06346565
119Skin ulcer (HP:0200042)2.05719046
120Gingival bleeding (HP:0000225)2.05085270
121Abnormal ciliary motility (HP:0012262)2.03673316
122T lymphocytopenia (HP:0005403)2.03267164
123Combined immunodeficiency (HP:0005387)2.02548997
124Abnormality of the nasal mucosa (HP:0000433)2.01747502
125Chronic sinusitis (HP:0011109)2.01411074
126Verrucae (HP:0200043)2.00979647
127Papilloma (HP:0012740)2.00979647
128Thrombocytosis (HP:0001894)1.99223233
129Autoimmune hemolytic anemia (HP:0001890)1.99142676
130Petechiae (HP:0000967)1.98476925
131Dysostosis multiplex (HP:0000943)1.97772845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.19228921
2BLK3.93000505
3KDR3.81129134
4MAP4K13.71250831
5TIE13.11330021
6IRAK33.01111756
7ERN12.69303782
8RIPK42.61412089
9PRPF4B2.39850002
10TBK12.38504254
11MST1R2.37425794
12TYK22.21100655
13TGFBR22.11275528
14MST42.09065063
15TXK2.04262426
16PIK3CG2.00860477
17JAK11.91472388
18IKBKB1.91303653
19IKBKE1.89004285
20PIK3CA1.84077700
21CSK1.74850180
22STK101.70531633
23JAK31.64296881
24MAP3K131.60780327
25IRAK41.58850068
26LYN1.53135192
27PBK1.48502714
28FRK1.38871578
29GRK61.38141407
30RIPK11.34932375
31SYK1.31476814
32OBSCN1.30676130
33FGFR31.27290631
34MAP3K101.26562755
35ZAP701.24750761
36TESK21.21387568
37KIT1.17987423
38CSF1R1.15693373
39PIM11.13049541
40BTK1.11739159
41GRK11.09210134
42MARK31.06179930
43HCK1.05020102
44TLK11.04797533
45NUAK11.04383226
46TEC1.02448925
47CHUK1.02116231
48MATK1.01036575
49CLK10.99665535
50LCK0.99139418
51BMPR20.98430961
52MAP2K30.91760230
53FGR0.88793506
54CDK90.87438231
55GRK70.87201494
56HIPK20.85045242
57EIF2AK30.84847686
58NLK0.83745953
59IRAK10.83120709
60MAPK70.83110293
61MAPK120.82359032
62INSRR0.81162585
63STK30.79786533
64LMTK20.79512223
65FGFR40.78680566
66TGFBR10.78560908
67MAP3K110.77866941
68YES10.75144941
69BMX0.74285933
70ACVR1B0.74192007
71PRKG20.71737761
72FES0.71498571
73MAP2K20.70893068
74TAOK20.70591250
75PDK10.70269590
76JAK20.70245567
77EIF2AK20.68394106
78CDK120.67843855
79MAP3K10.67714099
80STK240.67437257
81TRPM70.58871525
82MOS0.58426845
83PRKCQ0.56900920
84PRKCD0.56852562
85IGF1R0.55467811
86LRRK20.55050511
87CDK60.53910531
88TAOK30.53648049
89CDC42BPA0.53613270
90MUSK0.52487569
91MAP3K50.51945789
92STK40.51938649
93ITK0.51466847
94MAPK150.51141622
95ABL10.49775188
96EGFR0.49381194
97MELK0.48327546
98MAPK110.48293306
99CDK30.47374215
100RPS6KA50.47278777
101LATS10.46161497
102MAP3K30.45849697
103EPHA30.44632074
104ADRBK20.44401081
105MAP3K70.42720461
106MAP2K60.42550646
107TAOK10.40973220
108PTK60.40794300
109BCKDK0.40123833
110SIK30.40002273
111INSR0.39285008
112EPHB10.38278398
113MARK20.37830738
114PIM20.36172031
115BRD40.35762309
116TNK20.34291438
117BMPR1B0.34267802
118FYN0.33342943
119MAPK40.33316113
120MET0.32712176
121SGK30.32538411
122PKN10.32325049
123MAPK30.31877143
124PRKAA20.31842812
125SIK20.30222726
126NEK90.29932994
127CDK40.29401691
128RPS6KA40.29294085
129EPHB20.28151221
130MAPKAPK20.28031175
131MAP2K10.27855173
132SGK20.27490134
133PDPK10.25791058
134RPS6KB20.24239735

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.72502870
2Graft-versus-host disease_Homo sapiens_hsa053323.02675904
3Leishmaniasis_Homo sapiens_hsa051403.00593555
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.75500162
5Malaria_Homo sapiens_hsa051442.61695671
6Primary immunodeficiency_Homo sapiens_hsa053402.44306532
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.44186397
8B cell receptor signaling pathway_Homo sapiens_hsa046622.33797310
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.30429839
10African trypanosomiasis_Homo sapiens_hsa051432.29395078
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28422533
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.26357535
13Pertussis_Homo sapiens_hsa051332.22210617
14Legionellosis_Homo sapiens_hsa051342.17231651
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.13514831
16* Hematopoietic cell lineage_Homo sapiens_hsa046402.10588548
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.04787941
18Osteoclast differentiation_Homo sapiens_hsa043802.04184785
19Complement and coagulation cascades_Homo sapiens_hsa046101.81204087
20Salmonella infection_Homo sapiens_hsa051321.76055985
21Measles_Homo sapiens_hsa051621.75292945
22Tuberculosis_Homo sapiens_hsa051521.75022802
23Allograft rejection_Homo sapiens_hsa053301.68480623
24Influenza A_Homo sapiens_hsa051641.67307487
25TNF signaling pathway_Homo sapiens_hsa046681.64641640
26Nitrogen metabolism_Homo sapiens_hsa009101.60803946
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.54512743
28Rheumatoid arthritis_Homo sapiens_hsa053231.53493214
29Mineral absorption_Homo sapiens_hsa049781.43903061
30Herpes simplex infection_Homo sapiens_hsa051681.40790960
31Toxoplasmosis_Homo sapiens_hsa051451.32885273
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29208339
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29134630
34Antigen processing and presentation_Homo sapiens_hsa046121.26723493
35Chemokine signaling pathway_Homo sapiens_hsa040621.25902397
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.25045158
37Asthma_Homo sapiens_hsa053101.19293820
38Type I diabetes mellitus_Homo sapiens_hsa049401.18374719
39Hepatitis C_Homo sapiens_hsa051601.09874196
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09503467
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.06166021
42Bile secretion_Homo sapiens_hsa049761.00225729
43Other glycan degradation_Homo sapiens_hsa005110.98487513
44Lysosome_Homo sapiens_hsa041420.91739339
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90287819
46* Epstein-Barr virus infection_Homo sapiens_hsa051690.88504809
47Caffeine metabolism_Homo sapiens_hsa002320.88490286
48* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87030706
49Apoptosis_Homo sapiens_hsa042100.83567549
50Shigellosis_Homo sapiens_hsa051310.83134327
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82513741
52Fatty acid biosynthesis_Homo sapiens_hsa000610.81098869
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77852823
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77483422
55Hepatitis B_Homo sapiens_hsa051610.77020464
56Autoimmune thyroid disease_Homo sapiens_hsa053200.75917656
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75663896
58PPAR signaling pathway_Homo sapiens_hsa033200.74977772
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.73471472
60Viral myocarditis_Homo sapiens_hsa054160.73248929
61Platelet activation_Homo sapiens_hsa046110.72498920
62T cell receptor signaling pathway_Homo sapiens_hsa046600.72430935
63Prion diseases_Homo sapiens_hsa050200.72363344
64Renin-angiotensin system_Homo sapiens_hsa046140.70117797
65Viral carcinogenesis_Homo sapiens_hsa052030.68747324
66Phagosome_Homo sapiens_hsa041450.68462353
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67943800
68Amoebiasis_Homo sapiens_hsa051460.67856565
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67609175
70HTLV-I infection_Homo sapiens_hsa051660.62108989
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61433621
72Arginine biosynthesis_Homo sapiens_hsa002200.59467123
73Dorso-ventral axis formation_Homo sapiens_hsa043200.59285106
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57185929
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57108059
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57058971
77Vitamin digestion and absorption_Homo sapiens_hsa049770.56056017
78ABC transporters_Homo sapiens_hsa020100.53614818
79Non-small cell lung cancer_Homo sapiens_hsa052230.52238262
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.51664760
81Prolactin signaling pathway_Homo sapiens_hsa049170.50957395
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48715800
83Small cell lung cancer_Homo sapiens_hsa052220.47265010
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46298431
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37802362
86Adherens junction_Homo sapiens_hsa045200.34917826
87Fatty acid degradation_Homo sapiens_hsa000710.34485098
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32530923
89VEGF signaling pathway_Homo sapiens_hsa043700.32514203
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.32252316
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.31499714
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31103812
93Peroxisome_Homo sapiens_hsa041460.30907687
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30718617
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30377562
96HIF-1 signaling pathway_Homo sapiens_hsa040660.28713078
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28638089
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27228113
99Sphingolipid metabolism_Homo sapiens_hsa006000.27208774
100FoxO signaling pathway_Homo sapiens_hsa040680.25604372
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24574385
102Insulin resistance_Homo sapiens_hsa049310.23655577
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23303854
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22890331
105Notch signaling pathway_Homo sapiens_hsa043300.22847175
106Chemical carcinogenesis_Homo sapiens_hsa052040.22291036
107Systemic lupus erythematosus_Homo sapiens_hsa053220.21016279
108Chronic myeloid leukemia_Homo sapiens_hsa052200.20074231
109Pancreatic cancer_Homo sapiens_hsa052120.19843056
110Arachidonic acid metabolism_Homo sapiens_hsa005900.19219499
111Regulation of autophagy_Homo sapiens_hsa041400.18890750
112Acute myeloid leukemia_Homo sapiens_hsa052210.18571905
113Proteoglycans in cancer_Homo sapiens_hsa052050.17619721
114Histidine metabolism_Homo sapiens_hsa003400.17154138
115Alcoholism_Homo sapiens_hsa050340.15649870
116Prostate cancer_Homo sapiens_hsa052150.12259070
117Type II diabetes mellitus_Homo sapiens_hsa049300.11900729
118MAPK signaling pathway_Homo sapiens_hsa040100.08699163
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.06588640
120Inositol phosphate metabolism_Homo sapiens_hsa005620.04290049
121Olfactory transduction_Homo sapiens_hsa047400.03734712
122Choline metabolism in cancer_Homo sapiens_hsa052310.03714301
123Tryptophan metabolism_Homo sapiens_hsa003800.03362833
124Renin secretion_Homo sapiens_hsa049240.02805826
125mTOR signaling pathway_Homo sapiens_hsa041500.02437449
126GnRH signaling pathway_Homo sapiens_hsa049120.01482073
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.00381280
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0025460

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