CD3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)8.54397755
2cytidine catabolic process (GO:0006216)8.54397755
3cytidine deamination (GO:0009972)8.54397755
4negative T cell selection (GO:0043383)8.09845057
5positive regulation of gamma-delta T cell activation (GO:0046645)7.79402111
6pyrimidine ribonucleoside catabolic process (GO:0046133)7.77447386
7negative thymic T cell selection (GO:0045060)7.64985828
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.34476304
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.05191588
10DNA deamination (GO:0045006)6.99547617
11interferon-gamma production (GO:0032609)6.39796943
12leukocyte aggregation (GO:0070486)6.39609153
13regulation of gamma-delta T cell differentiation (GO:0045586)6.32786483
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.23390959
15negative regulation of cell killing (GO:0031342)6.23390959
16cellular response to interleukin-15 (GO:0071350)6.01583211
17regulation of gamma-delta T cell activation (GO:0046643)5.86544141
18regulation of isotype switching to IgG isotypes (GO:0048302)5.85680465
19* thymic T cell selection (GO:0045061)5.71069190
20* T cell receptor signaling pathway (GO:0050852)5.68994724
21response to interleukin-15 (GO:0070672)5.58829309
22* T cell selection (GO:0045058)5.43454482
23T cell migration (GO:0072678)5.42902268
24* positive T cell selection (GO:0043368)5.41727347
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.41229419
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.40788182
27regulation of T cell tolerance induction (GO:0002664)5.27541698
28* T cell costimulation (GO:0031295)5.16070932
29* positive thymic T cell selection (GO:0045059)5.10499876
30* lymphocyte costimulation (GO:0031294)5.10216138
31regulation of T cell receptor signaling pathway (GO:0050856)5.09951854
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.00239936
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.00239936
34sequestering of actin monomers (GO:0042989)4.93841975
35regulation of B cell receptor signaling pathway (GO:0050855)4.93563820
36* antigen receptor-mediated signaling pathway (GO:0050851)4.81719758
37positive regulation of alpha-beta T cell proliferation (GO:0046641)4.73767776
38regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.65070629
39negative regulation of T cell apoptotic process (GO:0070233)4.59971361
40positive regulation of natural killer cell mediated immunity (GO:0002717)4.59328021
41positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.59328021
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.56717093
43regulation of alpha-beta T cell proliferation (GO:0046640)4.47437592
44regulation of natural killer cell mediated immunity (GO:0002715)4.35811811
45regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.35811811
46polyketide metabolic process (GO:0030638)4.30562711
47doxorubicin metabolic process (GO:0044598)4.30562711
48daunorubicin metabolic process (GO:0044597)4.30562711
49regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.29995478
50positive regulation of tolerance induction (GO:0002645)4.26456245
51mast cell activation (GO:0045576)4.25714546
52regulation of chronic inflammatory response (GO:0002676)4.25018622
53negative regulation by host of viral transcription (GO:0043922)4.23012145
54negative regulation of T cell mediated immunity (GO:0002710)4.22092175
55positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.21829141
56regulation of lymphocyte chemotaxis (GO:1901623)4.18867948
57regulation of interleukin-2 biosynthetic process (GO:0045076)4.14972014
58positive regulation of interleukin-8 secretion (GO:2000484)4.12891221
59antigen processing and presentation of endogenous antigen (GO:0019883)4.11624893
60positive regulation of B cell differentiation (GO:0045579)4.08896712
61regulation of B cell differentiation (GO:0045577)4.08063746
62regulation of leukocyte mediated cytotoxicity (GO:0001910)4.05762288
63negative regulation of viral genome replication (GO:0045071)4.04123700
64activated T cell proliferation (GO:0050798)4.02843199
65positive regulation of cell killing (GO:0031343)3.90373140
66actin nucleation (GO:0045010)3.88926994
67regulation of activation of Janus kinase activity (GO:0010533)3.87986636
68regulation of cell killing (GO:0031341)3.85536207
69positive regulation of lymphocyte migration (GO:2000403)3.83641313
70positive regulation of T cell chemotaxis (GO:0010820)3.83459668
71regulation of T cell chemotaxis (GO:0010819)3.83459668
72positive regulation of B cell mediated immunity (GO:0002714)3.83021222
73positive regulation of immunoglobulin mediated immune response (GO:0002891)3.83021222
74pyrimidine nucleoside catabolic process (GO:0046135)3.78114634
75regulation of tolerance induction (GO:0002643)3.75444794
76cytolysis (GO:0019835)3.69061070
77natural killer cell activation (GO:0030101)3.68861894
78regulation of immunoglobulin mediated immune response (GO:0002889)3.68249644
79positive regulation of isotype switching (GO:0045830)3.67497208
80regulation of T cell mediated cytotoxicity (GO:0001914)3.66507879
81positive regulation of granulocyte differentiation (GO:0030854)3.65562513
82lymphocyte chemotaxis (GO:0048247)3.65358635
83negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.64478921
84positive regulation of interleukin-2 production (GO:0032743)3.63136521
85* T cell differentiation (GO:0030217)3.62458174
86antigen processing and presentation via MHC class Ib (GO:0002475)3.59667827
87eosinophil chemotaxis (GO:0048245)3.59617132
88response to type I interferon (GO:0034340)3.59501214
89tolerance induction (GO:0002507)3.59285560
90regulation of B cell mediated immunity (GO:0002712)3.56136548
91cellular response to type I interferon (GO:0071357)3.55551941
92type I interferon signaling pathway (GO:0060337)3.55551941
93* T cell activation (GO:0042110)3.54599367
94positive regulation of uterine smooth muscle contraction (GO:0070474)3.53350898
95regulation of isotype switching (GO:0045191)3.52803644
96negative regulation of lymphocyte mediated immunity (GO:0002707)3.50922588
97positive regulation of defense response to virus by host (GO:0002230)3.49641410
98regulation of type I interferon-mediated signaling pathway (GO:0060338)3.49389357
99heterotypic cell-cell adhesion (GO:0034113)3.48793887
100negative regulation of T cell receptor signaling pathway (GO:0050860)3.48637830
101regulation of response to interferon-gamma (GO:0060330)3.48089086
102leukocyte cell-cell adhesion (GO:0007159)3.44169641
103alpha-beta T cell differentiation (GO:0046632)3.44014659
104positive regulation of T cell mediated cytotoxicity (GO:0001916)3.41619479
105positive regulation of humoral immune response (GO:0002922)3.40933145
106regulation of regulatory T cell differentiation (GO:0045589)3.40786747
107positive regulation of lymphocyte mediated immunity (GO:0002708)3.37345944
108T cell homeostasis (GO:0043029)3.36608024
109regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.36280775
110macrophage chemotaxis (GO:0048246)3.35239543
111positive regulation of interferon-gamma production (GO:0032729)3.31702901
112alpha-beta T cell activation (GO:0046631)3.31243014
113negative regulation of lymphocyte apoptotic process (GO:0070229)3.30451600
114positive regulation of DNA recombination (GO:0045911)3.28893304
115positive regulation of calcium-mediated signaling (GO:0050850)3.26093364
116* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.24836932
117eosinophil migration (GO:0072677)3.24634346
118regulation of T cell apoptotic process (GO:0070232)3.23654494
119regulation of calcium-mediated signaling (GO:0050848)3.23515238
120Arp2/3 complex-mediated actin nucleation (GO:0034314)3.20067236
121lymphocyte migration (GO:0072676)3.19339889
122dendritic cell chemotaxis (GO:0002407)3.19172985
123mucosal-associated lymphoid tissue development (GO:0048537)3.18417585
124Peyers patch development (GO:0048541)3.18417585
125regulation of lymphocyte migration (GO:2000401)3.17812680
126T-helper cell differentiation (GO:0042093)3.16762086
127CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.16762086
128positive regulation of T cell migration (GO:2000406)3.15822233
129cellular defense response (GO:0006968)3.15084638
130positive regulation of interleukin-4 production (GO:0032753)3.14541338
131regulation of viral genome replication (GO:0045069)3.11351168
132regulation of defense response to virus by virus (GO:0050690)3.09073863
133regulation of lymphocyte mediated immunity (GO:0002706)3.08750164
134regulation of response to tumor cell (GO:0002834)3.08542698
135positive regulation of response to tumor cell (GO:0002836)3.08542698
136positive regulation of immune response to tumor cell (GO:0002839)3.08542698
137regulation of immune response to tumor cell (GO:0002837)3.08542698
138positive regulation of T cell mediated immunity (GO:0002711)3.07172019
139regulation of interleukin-12 biosynthetic process (GO:0045075)3.02224421
140negative regulation of B cell proliferation (GO:0030889)2.99231399

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.60385008
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.77797534
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.90074042
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.72815879
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.53447399
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.05061664
7STAT4_19710469_ChIP-ChIP_TH1__Mouse3.93956520
8RUNX_20019798_ChIP-Seq_JUKART_Human3.87388418
9* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.65888930
10MYB_26560356_Chip-Seq_TH2_Human3.43188426
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.33528020
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.08887066
13MAF_26560356_Chip-Seq_TH1_Human2.93428895
14MYC_22102868_ChIP-Seq_BL_Human2.80725554
15* UTX_26944678_Chip-Seq_JUKART_Human2.77873589
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.76320370
17* MYB_26560356_Chip-Seq_TH1_Human2.74842382
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.71708183
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.63376257
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62874811
21* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60735844
22E2F7_22180533_ChIP-Seq_HELA_Human2.59406641
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51243814
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.47463307
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.24898048
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09967740
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01447179
28* GATA3_27048872_Chip-Seq_THYMUS_Human2.00305520
29* MAF_26560356_Chip-Seq_TH2_Human1.96345739
30SPI1_23547873_ChIP-Seq_NB4_Human1.94533088
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91699697
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.86625960
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82197123
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.81331961
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78389064
36SCL_19346495_ChIP-Seq_HPC-7_Human1.73489465
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61051051
38RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.60734515
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59291009
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57991047
41VDR_21846776_ChIP-Seq_THP-1_Human1.53683991
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45386795
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43686857
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43416320
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.41260994
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38287359
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36553666
48GATA3_26560356_Chip-Seq_TH2_Human1.30578567
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29199347
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25660482
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24823512
52GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24304465
53VDR_23849224_ChIP-Seq_CD4+_Human1.24185149
54PU_27001747_Chip-Seq_BMDM_Mouse1.22393688
55SPI1_23127762_ChIP-Seq_K562_Human1.22326576
56* TCF7_22412390_ChIP-Seq_EML_Mouse1.22170798
57VDR_24763502_ChIP-Seq_THP-1_Human1.20196395
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17860222
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.17253567
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15506857
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.14453012
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11098309
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10092055
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09396520
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05947441
66FOXP3_21729870_ChIP-Seq_TREG_Human1.04341680
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03535720
68BCL6_27268052_Chip-Seq_Bcells_Human1.00271323
69CIITA_25753668_ChIP-Seq_RAJI_Human0.99900790
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97991922
71GATA3_26560356_Chip-Seq_TH1_Human0.97469276
72STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97398357
73ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96750327
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96211303
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94977734
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94784447
77TP63_19390658_ChIP-ChIP_HaCaT_Human0.93685139
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92057903
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89883786
80HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89731294
81RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89427477
82* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87109430
83KDM2B_26808549_Chip-Seq_DND41_Human0.86745410
84* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85689334
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84257968
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83275724
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82982762
88ELK1_19687146_ChIP-ChIP_HELA_Human0.82343114
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.81571244
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81181980
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.80486778
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80407878
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79198415
94E2F4_17652178_ChIP-ChIP_JURKAT_Human0.79073292
95P300_27268052_Chip-Seq_Bcells_Human0.78966845
96* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78816972
97SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.78574229
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78224042
99VDR_22108803_ChIP-Seq_LS180_Human0.77441373
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76043554
101TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.75666090
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75204392
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74390224
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.73588363
105ELF1_20517297_ChIP-Seq_JURKAT_Human0.73575415
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.72049255
107GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.71779558
108HTT_18923047_ChIP-ChIP_STHdh_Human0.70044266
109GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.70033839
110KDM2B_26808549_Chip-Seq_SUP-B15_Human0.69960818
111NANOG_20526341_ChIP-Seq_ESCs_Human0.69914571
112BCOR_27268052_Chip-Seq_Bcells_Human0.69571107
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.68972785
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66360914
115KDM2B_26808549_Chip-Seq_JURKAT_Human0.65381992
116TAF2_19829295_ChIP-Seq_ESCs_Human0.65128092
117ETS1_20019798_ChIP-Seq_JURKAT_Human0.64068041
118CTCF_20526341_ChIP-Seq_ESCs_Human0.63271622
119BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62550574
120FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.62346918
121* SA1_27219007_Chip-Seq_Bcells_Human0.62327020
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.62103019
123VDR_24787735_ChIP-Seq_THP-1_Human0.61254426
124FOXM1_23109430_ChIP-Seq_U2OS_Human0.59384143
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.59322929
126IKZF1_21737484_ChIP-ChIP_HCT116_Human0.58912241
127TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.57872296
128GABP_17652178_ChIP-ChIP_JURKAT_Human0.57840302
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.57750508
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.56397969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.05939614
2MP0005671_abnormal_response_to5.34532089
3MP0001835_abnormal_antigen_presentation3.55767629
4MP0000685_abnormal_immune_system3.48256191
5MP0002166_altered_tumor_susceptibility3.39111009
6MP0009785_altered_susceptibility_to3.31450537
7MP0001800_abnormal_humoral_immune3.08206530
8MP0002006_tumorigenesis2.99449499
9MP0005387_immune_system_phenotype2.95719545
10MP0001790_abnormal_immune_system2.95719545
11MP0005000_abnormal_immune_tolerance2.95110995
12MP0002420_abnormal_adaptive_immunity2.90963888
13MP0001819_abnormal_immune_cell2.89472511
14MP0002723_abnormal_immune_serum2.84962561
15MP0009333_abnormal_splenocyte_physiolog2.80785887
16* MP0002398_abnormal_bone_marrow2.77711398
17MP0003724_increased_susceptibility_to2.76885008
18MP0006082_CNS_inflammation2.72896158
19MP0005025_abnormal_response_to2.67840142
20* MP0000703_abnormal_thymus_morphology2.66472855
21MP0002452_abnormal_antigen_presenting2.50319161
22MP0004381_abnormal_hair_follicle2.46982688
23* MP0000716_abnormal_immune_system2.46045766
24MP0002405_respiratory_system_inflammati2.43468912
25* MP0002722_abnormal_immune_system2.28244916
26MP0002933_joint_inflammation2.11088490
27MP0000689_abnormal_spleen_morphology2.07440641
28MP0004947_skin_inflammation2.05745265
29MP0010155_abnormal_intestine_physiology2.04876218
30MP0003866_abnormal_defecation2.02614809
31MP0002148_abnormal_hypersensitivity_rea1.99019272
32* MP0002429_abnormal_blood_cell1.94885337
33MP0002396_abnormal_hematopoietic_system1.91244945
34MP0001873_stomach_inflammation1.88560400
35MP0002419_abnormal_innate_immunity1.85590400
36MP0002132_abnormal_respiratory_system1.81963536
37MP0003436_decreased_susceptibility_to1.81190028
38MP0004510_myositis1.66247996
39MP0000858_altered_metastatic_potential1.65097672
40MP0005310_abnormal_salivary_gland1.58957778
41MP0001845_abnormal_inflammatory_respons1.58510746
42MP0005464_abnormal_platelet_physiology1.47813878
43MP0003878_abnormal_ear_physiology1.46051278
44MP0005377_hearing/vestibular/ear_phenot1.46051278
45MP0005075_abnormal_melanosome_morpholog1.29857294
46MP0002009_preneoplasia1.29753127
47MP0003448_altered_tumor_morphology1.28677997
48MP0003300_gastrointestinal_ulcer1.24275994
49MP0001851_eye_inflammation1.23092293
50MP0001853_heart_inflammation1.23040553
51MP0002163_abnormal_gland_morphology1.17314941
52MP0008057_abnormal_DNA_replication1.16421837
53MP0003045_fibrosis1.10678222
54MP0003786_premature_aging1.07384429
55MP0000490_abnormal_crypts_of1.04479332
56MP0008469_abnormal_protein_level1.04478758
57MP0002998_abnormal_bone_remodeling1.03544254
58MP0004808_abnormal_hematopoietic_stem0.97501375
59MP0002019_abnormal_tumor_incidence0.94927136
60MP0005645_abnormal_hypothalamus_physiol0.89970326
61MP0006292_abnormal_olfactory_placode0.88561794
62MP0001533_abnormal_skeleton_physiology0.88179629
63MP0005166_decreased_susceptibility_to0.83877984
64MP0000604_amyloidosis0.83399883
65MP0008004_abnormal_stomach_pH0.81404671
66MP0001986_abnormal_taste_sensitivity0.74131520
67MP0005379_endocrine/exocrine_gland_phen0.74123543
68MP0002277_abnormal_respiratory_mucosa0.70977673
69MP0000465_gastrointestinal_hemorrhage0.69418861
70MP0009764_decreased_sensitivity_to0.68500145
71MP0001663_abnormal_digestive_system0.68383833
72MP0002095_abnormal_skin_pigmentation0.67648225
73MP0000015_abnormal_ear_pigmentation0.64567941
74MP0003795_abnormal_bone_structure0.64519183
75MP0001765_abnormal_ion_homeostasis0.62686308
76MP0002876_abnormal_thyroid_physiology0.61515271
77MP0009763_increased_sensitivity_to0.61317203
78MP0005174_abnormal_tail_pigmentation0.61091194
79MP0005397_hematopoietic_system_phenotyp0.59561709
80MP0001545_abnormal_hematopoietic_system0.59561709
81MP0010094_abnormal_chromosome_stability0.59007621
82MP0003303_peritoneal_inflammation0.58769625
83MP0003693_abnormal_embryo_hatching0.58377815
84MP0003646_muscle_fatigue0.57692080
85MP0003077_abnormal_cell_cycle0.57135818
86MP0008873_increased_physiological_sensi0.56936796
87MP0008872_abnormal_physiological_respon0.55480933
88MP0002693_abnormal_pancreas_physiology0.54058248
89MP0001191_abnormal_skin_condition0.53884096
90MP0002877_abnormal_melanocyte_morpholog0.51728865
91MP0002138_abnormal_hepatobiliary_system0.51345476
92MP0009643_abnormal_urine_homeostasis0.50854716
93MP0001501_abnormal_sleep_pattern0.50788656
94MP0003075_altered_response_to0.50664298
95MP0003806_abnormal_nucleotide_metabolis0.49521962
96MP0005451_abnormal_body_composition0.48530791
97MP0005389_reproductive_system_phenotype0.48064007
98MP0000477_abnormal_intestine_morphology0.47588303
99MP0003453_abnormal_keratinocyte_physiol0.46208674
100MP0005409_darkened_coat_color0.45772273
101MP0003879_abnormal_hair_cell0.45716552
102MP0001348_abnormal_lacrimal_gland0.44906528
103MP0003787_abnormal_imprinting0.44714548
104MP0005023_abnormal_wound_healing0.44433325
105MP0001905_abnormal_dopamine_level0.43133757
106MP0005636_abnormal_mineral_homeostasis0.43061000
107MP0001243_abnormal_dermal_layer0.42695996
108MP0008995_early_reproductive_senescence0.42093066
109MP0002136_abnormal_kidney_physiology0.41560450
110MP0001216_abnormal_epidermal_layer0.41237339
111MP0008007_abnormal_cellular_replicative0.40336743
112MP0009765_abnormal_xenobiotic_induced0.40103524
113MP0001881_abnormal_mammary_gland0.39826522
114MP0000627_abnormal_mammary_gland0.39360673
115MP0001119_abnormal_female_reproductive0.39151564
116MP0000920_abnormal_myelination0.39003813
117MP0000372_irregular_coat_pigmentation0.38771166
118MP0008058_abnormal_DNA_repair0.38693275
119MP0003111_abnormal_nucleus_morphology0.38562000
120MP0002928_abnormal_bile_duct0.38489148
121MP0001919_abnormal_reproductive_system0.38130376
122MP0001661_extended_life_span0.37962075
123MP0005390_skeleton_phenotype0.36644588
124MP0003252_abnormal_bile_duct0.35704473
125MP0004145_abnormal_muscle_electrophysio0.35352701
126MP0002083_premature_death0.34047681
127MP0005584_abnormal_enzyme/coenzyme_acti0.33911974
128MP0000249_abnormal_blood_vessel0.33756051
129MP0004742_abnormal_vestibular_system0.33688772

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.86130340
2Abnormality of T cell number (HP:0011839)7.71158276
3Severe combined immunodeficiency (HP:0004430)6.62500742
4Combined immunodeficiency (HP:0005387)6.00081645
5Elevated erythrocyte sedimentation rate (HP:0003565)5.64804797
6Abnormality of T cells (HP:0002843)5.32601046
7Autoimmune hemolytic anemia (HP:0001890)5.32063123
8IgG deficiency (HP:0004315)5.21252455
9Increased IgM level (HP:0003496)5.19651997
10Stomatitis (HP:0010280)5.09621884
11Aplastic anemia (HP:0001915)4.93576527
12Recurrent bronchitis (HP:0002837)4.51204634
13Recurrent cutaneous fungal infections (HP:0011370)4.50099387
14Chronic mucocutaneous candidiasis (HP:0002728)4.50099387
15Thyroiditis (HP:0100646)4.49270647
16Chronic otitis media (HP:0000389)4.44884011
17Recurrent fungal infections (HP:0002841)4.32957224
18Abnormality of eosinophils (HP:0001879)4.30281948
19Myositis (HP:0100614)4.11848425
20Abnormality of B cell number (HP:0010975)4.03323093
21B lymphocytopenia (HP:0010976)4.03323093
22Panhypogammaglobulinemia (HP:0003139)3.98162182
23Eczematoid dermatitis (HP:0000976)3.92440116
24Hypoplasia of the thymus (HP:0000778)3.82474462
25Chronic diarrhea (HP:0002028)3.82327446
26IgM deficiency (HP:0002850)3.76767228
27Eosinophilia (HP:0001880)3.74723363
28Leukocytosis (HP:0001974)3.68528496
29Cheilitis (HP:0100825)3.62168858
30Recurrent viral infections (HP:0004429)3.58942146
31Optic neuritis (HP:0100653)3.50804067
32Retrobulbar optic neuritis (HP:0100654)3.50804067
33Abnormality of macrophages (HP:0004311)3.39843221
34Granulocytopenia (HP:0001913)3.34231312
35Joint swelling (HP:0001386)3.18103644
36Orchitis (HP:0100796)3.16859146
37Abnormality of T cell physiology (HP:0011840)3.12129959
38Nasal polyposis (HP:0100582)3.08945088
39* Lymphopenia (HP:0001888)3.06172133
40Pustule (HP:0200039)3.01957520
41* Abnormality of cells of the lymphoid lineage (HP:0012140)3.00500354
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.99257914
43Parakeratosis (HP:0001036)2.97244552
44Hypergammaglobulinemia (HP:0010702)2.93652701
45Abnormality of the fingertips (HP:0001211)2.92944751
46Meningitis (HP:0001287)2.91673113
47Recurrent abscess formation (HP:0002722)2.87898868
48Hemoptysis (HP:0002105)2.87253402
49Chest pain (HP:0100749)2.85953801
50Vasculitis (HP:0002633)2.82540930
51Lymphoma (HP:0002665)2.73494989
52Recurrent sinusitis (HP:0011108)2.72579915
53Obstructive lung disease (HP:0006536)2.61948797
54Chronic obstructive pulmonary disease (HP:0006510)2.61948797
55Pulmonary infiltrates (HP:0002113)2.61075353
56Mediastinal lymphadenopathy (HP:0100721)2.58243826
57Encephalitis (HP:0002383)2.54831344
58Abnormality of the nasal mucosa (HP:0000433)2.51223624
59Recurrent skin infections (HP:0001581)2.49731776
60Bronchitis (HP:0012387)2.48479874
61Acute hepatic failure (HP:0006554)2.48203641
623-Methylglutaconic aciduria (HP:0003535)2.47563195
63Gastrointestinal infarctions (HP:0005244)2.46193122
64Ureteral stenosis (HP:0000071)2.40670087
65Hypoproteinemia (HP:0003075)2.40386818
66Abnormality of the prostate (HP:0008775)2.40247550
67Chronic sinusitis (HP:0011109)2.37691054
68Keratoconjunctivitis sicca (HP:0001097)2.36301604
69Agammaglobulinemia (HP:0004432)2.36174795
70Hemiplegia (HP:0002301)2.31663169
71Keratitis (HP:0000491)2.30376534
72IgA deficiency (HP:0002720)2.29862793
73Ureteral obstruction (HP:0006000)2.25881994
74Abnormal albumin level (HP:0012116)2.21891088
75Hypoalbuminemia (HP:0003073)2.21891088
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19725965
77Autoimmune thrombocytopenia (HP:0001973)2.18787626
78Unilateral renal agenesis (HP:0000122)2.18614335
79Pancytopenia (HP:0001876)2.17438337
80Increased intramyocellular lipid droplets (HP:0012240)2.17289434
81Abnormality of DNA repair (HP:0003254)2.17266159
82Keratoconjunctivitis (HP:0001096)2.14057302
83Bilateral sensorineural hearing impairment (HP:0008619)2.05984562
84Oral leukoplakia (HP:0002745)2.00981765
85Pulmonary fibrosis (HP:0002206)1.99574574
86Gangrene (HP:0100758)1.97746969
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97322613
88Skin rash (HP:0000988)1.96472457
89Reduced subcutaneous adipose tissue (HP:0003758)1.96323969
90Premature graying of hair (HP:0002216)1.94214663
91Mitochondrial inheritance (HP:0001427)1.93724678
92Polyneuropathy (HP:0001271)1.90303835
93Abnormality of male internal genitalia (HP:0000022)1.90097286
94Bronchiectasis (HP:0002110)1.88936749
95Gingivitis (HP:0000230)1.88781447
96Microcytic anemia (HP:0001935)1.88635979
97Muscle fiber atrophy (HP:0100295)1.88402563
98Aplasia/Hypoplasia of the thymus (HP:0010515)1.88287487
99Abnormality of the endocardium (HP:0004306)1.87332324
100Arterial thrombosis (HP:0004420)1.86411351
101Glomerulopathy (HP:0100820)1.84570400
102Abnormality of the pleura (HP:0002103)1.82678931
103Increased IgE level (HP:0003212)1.82542239
104Poikiloderma (HP:0001029)1.82315028
105Spontaneous hematomas (HP:0007420)1.82161205
106Anorexia (HP:0002039)1.80463324
107Increased muscle lipid content (HP:0009058)1.79878048
108Type 2 muscle fiber atrophy (HP:0003554)1.77012109
109Epistaxis (HP:0000421)1.76728963
110Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75582195
111Basal cell carcinoma (HP:0002671)1.75184223
112Pulmonary embolism (HP:0002204)1.75182830
113Congenital stationary night blindness (HP:0007642)1.74927521
114Clubbing of toes (HP:0100760)1.72993679
115Renal cortical cysts (HP:0000803)1.72990037
116Recurrent bacterial skin infections (HP:0005406)1.72977337
117Acute necrotizing encephalopathy (HP:0006965)1.72895252
118Inflammation of the large intestine (HP:0002037)1.71864234
119Basal ganglia calcification (HP:0002135)1.71515799
120Gastrointestinal inflammation (HP:0004386)1.70981565
121Ectropion (HP:0000656)1.70587414
122Increased hepatocellular lipid droplets (HP:0006565)1.69247828
123Severe visual impairment (HP:0001141)1.68830596
124Large eyes (HP:0001090)1.68657607
125Alopecia of scalp (HP:0002293)1.68387452
126Abnormal rod and cone electroretinograms (HP:0008323)1.67344173
127Hypochromic anemia (HP:0001931)1.66501154
128Entropion (HP:0000621)1.66344962
129Abnormality of the pericardium (HP:0001697)1.64826808
130Petechiae (HP:0000967)1.63483152
131Prolonged bleeding time (HP:0003010)1.62703062
132Skin ulcer (HP:0200042)1.61879391

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.86551480
2MAP4K15.00870105
3ZAP703.55233048
4IKBKE3.40801275
5ITK3.22093977
6FGFR42.99891689
7SIK32.81835650
8JAK32.76933613
9KDR2.55528742
10TYK22.49548141
11NLK2.21594673
12TAOK32.09663670
13TEC2.08294537
14LCK2.06193222
15MAP3K142.04107368
16TBK11.98490891
17TESK21.96272262
18JAK11.94172628
19FGFR31.86798351
20NME21.85978622
21SIK21.78847796
22STK101.71955285
23RIPK41.69559434
24MAP3K121.66723798
25GRK61.66713213
26CSK1.61771904
27SYK1.59368775
28BLK1.50121431
29MST41.48922524
30HCK1.47867619
31BCKDK1.46438439
32BTK1.43446571
33SCYL21.39134668
34IRAK41.36755199
35CAMKK21.30283169
36MARK31.24893456
37KIT1.18447247
38TYRO31.18032134
39SIK11.15177917
40TNK21.13382499
41PASK1.11897556
42ZAK1.09790930
43TLK11.07979927
44CLK11.02859242
45PRKCQ1.02806199
46PRKCH1.00584603
47LYN0.95497634
48CAMKK10.94338380
49BUB10.92379541
50IKBKB0.92164171
51VRK20.85128951
52MAPKAPK30.77953743
53ADRBK20.75568309
54PIK3CG0.73388891
55STK160.72996480
56MAPK110.71724997
57PIK3CA0.71317239
58MAP3K130.71100373
59CDK30.64266361
60FYN0.61059525
61SRPK10.60216257
62MARK20.59264009
63RPS6KA40.57816726
64PIM10.55813583
65EIF2AK10.53789431
66DAPK10.53600536
67JAK20.53465675
68MAP2K60.53443159
69TAOK20.52158351
70PRKD20.51984701
71WNK40.50414613
72FES0.49887110
73CHUK0.48179384
74PDGFRB0.46973895
75BMPR20.46344327
76TESK10.45246486
77EEF2K0.44504533
78IGF1R0.44245642
79BRD40.41593531
80PRPF4B0.41454929
81STK40.40682509
82MAPKAPK20.40668459
83GRK10.40464472
84MAP3K70.39621701
85* INSR0.38323252
86FGFR20.36989819
87LIMK10.36842516
88TGFBR20.35608893
89CDK120.35405856
90STK380.34865606
91MAP3K30.34643680
92IRAK20.33336460
93IRAK10.32508450
94LRRK20.31893487
95CDK40.31823547
96MYLK0.30965495
97TNIK0.30156564
98MAP3K100.30034361
99MATK0.30027363
100ACVR1B0.29891628
101FGFR10.28867824
102MUSK0.28792883
103HIPK20.28412446
104NUAK10.27930832
105EIF2AK20.26100693
106MAPK70.25184384
107MAP4K20.24231495
108ATR0.23683248
109EIF2AK30.23669044
110RPS6KA50.23305122
111CSF1R0.22149172
112PRKCD0.21605044
113MAPK30.20627350
114EPHA30.20197589
115MAP3K50.20131413
116MAP3K10.19990327
117PRKCA0.19870232
118VRK10.18087415
119CDK90.17878889
120GRK50.17674433
121GRK70.17639688
122STK240.16924383
123MAP3K110.16009501
124TRIM280.15869791
125ABL10.15476136
126SRC0.15165295
127PRKCB0.15003742
128MAPK120.14849816
129TAOK10.14427447
130MELK0.14274980
131PDK10.13315206
132EGFR0.13271916
133CDK80.12748542
134PAK10.12105700
135NEK60.12050942
136CSNK1D0.11759448

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053405.91101261
2Graft-versus-host disease_Homo sapiens_hsa053324.11560173
3* T cell receptor signaling pathway_Homo sapiens_hsa046603.69573866
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.51280303
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.06826430
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.92212669
7* Measles_Homo sapiens_hsa051622.91174260
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.72827440
9Allograft rejection_Homo sapiens_hsa053302.72692163
10Antigen processing and presentation_Homo sapiens_hsa046122.70199602
11* Hematopoietic cell lineage_Homo sapiens_hsa046402.48964039
12Autoimmune thyroid disease_Homo sapiens_hsa053202.22127855
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12895374
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83029906
15Viral myocarditis_Homo sapiens_hsa054161.76189775
16Leishmaniasis_Homo sapiens_hsa051401.72326331
17Herpes simplex infection_Homo sapiens_hsa051681.60635013
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.59859369
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.59839236
20Osteoclast differentiation_Homo sapiens_hsa043801.56127371
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45017342
22Ribosome_Homo sapiens_hsa030101.29593096
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29325877
24Oxidative phosphorylation_Homo sapiens_hsa001901.28804215
25* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23003166
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19825188
27Non-homologous end-joining_Homo sapiens_hsa034501.18037599
28Chemokine signaling pathway_Homo sapiens_hsa040621.17867290
29Asthma_Homo sapiens_hsa053101.14908698
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.13620447
31Hepatitis B_Homo sapiens_hsa051611.12742418
32Parkinsons disease_Homo sapiens_hsa050121.08313955
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06052948
34B cell receptor signaling pathway_Homo sapiens_hsa046621.03614643
35* HTLV-I infection_Homo sapiens_hsa051661.02252434
36Type I diabetes mellitus_Homo sapiens_hsa049401.02034996
37Influenza A_Homo sapiens_hsa051641.00996985
38Spliceosome_Homo sapiens_hsa030401.00747097
39Shigellosis_Homo sapiens_hsa051310.99221610
40Toxoplasmosis_Homo sapiens_hsa051450.97077406
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93960072
42NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88768197
43Malaria_Homo sapiens_hsa051440.88433621
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87401618
45Apoptosis_Homo sapiens_hsa042100.83380406
46Staphylococcus aureus infection_Homo sapiens_hsa051500.76837178
47Acute myeloid leukemia_Homo sapiens_hsa052210.75968930
48DNA replication_Homo sapiens_hsa030300.75067524
49Proteasome_Homo sapiens_hsa030500.74180460
50Tuberculosis_Homo sapiens_hsa051520.72613840
51p53 signaling pathway_Homo sapiens_hsa041150.71856149
52TNF signaling pathway_Homo sapiens_hsa046680.71670181
53Nucleotide excision repair_Homo sapiens_hsa034200.69927816
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69018673
55Hepatitis C_Homo sapiens_hsa051600.67089153
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66986652
57Alzheimers disease_Homo sapiens_hsa050100.65686507
58Basal transcription factors_Homo sapiens_hsa030220.64766405
59Colorectal cancer_Homo sapiens_hsa052100.63645818
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62427760
61Fanconi anemia pathway_Homo sapiens_hsa034600.62079356
62Epstein-Barr virus infection_Homo sapiens_hsa051690.61625836
63Salmonella infection_Homo sapiens_hsa051320.61461690
64Pancreatic cancer_Homo sapiens_hsa052120.61219089
65Legionellosis_Homo sapiens_hsa051340.61070684
66Rheumatoid arthritis_Homo sapiens_hsa053230.60217386
67Notch signaling pathway_Homo sapiens_hsa043300.59706670
68Homologous recombination_Homo sapiens_hsa034400.58215105
69Viral carcinogenesis_Homo sapiens_hsa052030.57880828
70RNA degradation_Homo sapiens_hsa030180.55269011
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54410662
72Pertussis_Homo sapiens_hsa051330.51272626
73Other glycan degradation_Homo sapiens_hsa005110.51181959
74Platelet activation_Homo sapiens_hsa046110.50975167
75Mismatch repair_Homo sapiens_hsa034300.48276938
76Phototransduction_Homo sapiens_hsa047440.48134627
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45587101
78Regulation of autophagy_Homo sapiens_hsa041400.45030548
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44046862
80Prolactin signaling pathway_Homo sapiens_hsa049170.43652903
81Linoleic acid metabolism_Homo sapiens_hsa005910.43182899
82Base excision repair_Homo sapiens_hsa034100.42189814
83Prion diseases_Homo sapiens_hsa050200.42021791
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40170841
85Adherens junction_Homo sapiens_hsa045200.39463860
86Huntingtons disease_Homo sapiens_hsa050160.39044255
87African trypanosomiasis_Homo sapiens_hsa051430.38773402
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38017525
89Caffeine metabolism_Homo sapiens_hsa002320.37557425
90Nitrogen metabolism_Homo sapiens_hsa009100.34775863
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34633238
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33679578
93VEGF signaling pathway_Homo sapiens_hsa043700.32998182
94RNA polymerase_Homo sapiens_hsa030200.32883081
95Rap1 signaling pathway_Homo sapiens_hsa040150.32165338
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31918103
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31874832
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30464738
99FoxO signaling pathway_Homo sapiens_hsa040680.29465267
100Endocytosis_Homo sapiens_hsa041440.29010963
101Chronic myeloid leukemia_Homo sapiens_hsa052200.28670279
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.27979306
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27316836
104Cell cycle_Homo sapiens_hsa041100.25489899
105Cardiac muscle contraction_Homo sapiens_hsa042600.24917893
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24782317
107Thyroid cancer_Homo sapiens_hsa052160.24139819
108Protein export_Homo sapiens_hsa030600.23183465
109mRNA surveillance pathway_Homo sapiens_hsa030150.23154401
110Pyrimidine metabolism_Homo sapiens_hsa002400.21805619
111Non-small cell lung cancer_Homo sapiens_hsa052230.21400644
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18267341
113Olfactory transduction_Homo sapiens_hsa047400.18096904
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16341498
115Pathways in cancer_Homo sapiens_hsa052000.15996862
116Small cell lung cancer_Homo sapiens_hsa052220.14980957
117MAPK signaling pathway_Homo sapiens_hsa040100.14863992
118Choline metabolism in cancer_Homo sapiens_hsa052310.14526767
119Ras signaling pathway_Homo sapiens_hsa040140.13936948
120Wnt signaling pathway_Homo sapiens_hsa043100.13893089
121Systemic lupus erythematosus_Homo sapiens_hsa053220.13137232
122Peroxisome_Homo sapiens_hsa041460.11595250
123Purine metabolism_Homo sapiens_hsa002300.10171160
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.09938408
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.06542397
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05978193
127Collecting duct acid secretion_Homo sapiens_hsa049660.05396543
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.04642566
129Phagosome_Homo sapiens_hsa041450.02070197

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