CD3EAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.55278302
2termination of RNA polymerase III transcription (GO:0006386)4.49970148
3transcription elongation from RNA polymerase III promoter (GO:0006385)4.49970148
4proteasome assembly (GO:0043248)4.41804273
5DNA deamination (GO:0045006)4.39593440
6ribosomal large subunit biogenesis (GO:0042273)4.27815089
7ribosomal small subunit assembly (GO:0000028)4.25945577
8ribosomal small subunit biogenesis (GO:0042274)4.19444492
9ribonucleoprotein complex biogenesis (GO:0022613)4.05146069
10DNA replication initiation (GO:0006270)4.03217527
11regulation of nuclear cell cycle DNA replication (GO:0033262)3.99236412
12telomere maintenance via semi-conservative replication (GO:0032201)3.96579368
13DNA strand elongation involved in DNA replication (GO:0006271)3.93660375
14ribosome biogenesis (GO:0042254)3.93075276
15DNA replication checkpoint (GO:0000076)3.89116869
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.83099669
17DNA strand elongation (GO:0022616)3.81157612
18regulation of mitochondrial translation (GO:0070129)3.80470882
19replication fork processing (GO:0031297)3.73267923
20rRNA processing (GO:0006364)3.71463302
21pseudouridine synthesis (GO:0001522)3.70203517
22spliceosomal snRNP assembly (GO:0000387)3.69549304
23rRNA modification (GO:0000154)3.66981765
24viral transcription (GO:0019083)3.60560352
25behavioral response to nicotine (GO:0035095)3.59705149
26viral mRNA export from host cell nucleus (GO:0046784)3.59605323
27rRNA metabolic process (GO:0016072)3.59129809
28nucleobase biosynthetic process (GO:0046112)3.57994560
29translational termination (GO:0006415)3.56934592
30telomere maintenance via recombination (GO:0000722)3.56017059
31IMP biosynthetic process (GO:0006188)3.52204557
32mitochondrial RNA metabolic process (GO:0000959)3.48618800
33tRNA methylation (GO:0030488)3.46953900
34mitochondrial respiratory chain complex assembly (GO:0033108)3.42310740
35respiratory chain complex IV assembly (GO:0008535)3.42091424
36telomere maintenance via telomere lengthening (GO:0010833)3.41861968
37CENP-A containing nucleosome assembly (GO:0034080)3.39144335
387-methylguanosine mRNA capping (GO:0006370)3.37597152
39protein complex biogenesis (GO:0070271)3.37524252
40RNA capping (GO:0036260)3.37123227
417-methylguanosine RNA capping (GO:0009452)3.37123227
42kinetochore assembly (GO:0051382)3.35688880
43chromatin remodeling at centromere (GO:0031055)3.34920078
44spliceosomal complex assembly (GO:0000245)3.33560326
45DNA replication-dependent nucleosome organization (GO:0034723)3.30976994
46DNA replication-dependent nucleosome assembly (GO:0006335)3.30976994
47cellular component biogenesis (GO:0044085)3.30917643
48purine nucleobase biosynthetic process (GO:0009113)3.30461844
49formation of translation preinitiation complex (GO:0001731)3.30274403
50transcription elongation from RNA polymerase I promoter (GO:0006362)3.29498086
51transcription-coupled nucleotide-excision repair (GO:0006283)3.27769733
52peptidyl-histidine modification (GO:0018202)3.25332602
53termination of RNA polymerase I transcription (GO:0006363)3.25158952
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.23862136
55NADH dehydrogenase complex assembly (GO:0010257)3.23862136
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23862136
57regulation of gene silencing by RNA (GO:0060966)3.23345701
58regulation of posttranscriptional gene silencing (GO:0060147)3.23345701
59regulation of gene silencing by miRNA (GO:0060964)3.23345701
60mitotic recombination (GO:0006312)3.22828814
61kinetochore organization (GO:0051383)3.22030662
62chaperone-mediated protein transport (GO:0072321)3.20738824
63cullin deneddylation (GO:0010388)3.20493187
64transcription from RNA polymerase I promoter (GO:0006360)3.20161946
65transcription from mitochondrial promoter (GO:0006390)3.19570010
66translational initiation (GO:0006413)3.18472808
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18062200
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18062200
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15970488
70DNA strand renaturation (GO:0000733)3.15810558
71regulation of double-strand break repair via homologous recombination (GO:0010569)3.14503878
72cytochrome complex assembly (GO:0017004)3.14221300
73somatic hypermutation of immunoglobulin genes (GO:0016446)3.13688281
74somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13688281
75histone exchange (GO:0043486)3.12712793
76mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12022484
77mitotic metaphase plate congression (GO:0007080)3.09959456
78DNA catabolic process, exonucleolytic (GO:0000738)3.09735155
79cotranslational protein targeting to membrane (GO:0006613)3.09415956
80maturation of 5.8S rRNA (GO:0000460)3.09066352
81translational elongation (GO:0006414)3.08981530
82translation (GO:0006412)3.08242866
83DNA-templated transcription, termination (GO:0006353)3.07995354
84protein targeting to ER (GO:0045047)3.06713401
85ncRNA processing (GO:0034470)3.06237579
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.05718082
87tRNA modification (GO:0006400)3.02732829
88protein-cofactor linkage (GO:0018065)3.02338332
89rRNA methylation (GO:0031167)3.02112842
90protein deneddylation (GO:0000338)3.01588302
91DNA damage response, detection of DNA damage (GO:0042769)3.01549082
92meiotic chromosome segregation (GO:0045132)3.00961089
93maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98923990
94DNA double-strand break processing (GO:0000729)2.98527453
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98233928
96mismatch repair (GO:0006298)2.96981249
97nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.96182758
98negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96028637
99IMP metabolic process (GO:0046040)2.95854686
100recombinational repair (GO:0000725)2.95673987
101double-strand break repair via homologous recombination (GO:0000724)2.94079487
102establishment of integrated proviral latency (GO:0075713)2.91352079
103ncRNA metabolic process (GO:0034660)2.91042487
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.90901701
105ATP synthesis coupled proton transport (GO:0015986)2.90662079
106energy coupled proton transport, down electrochemical gradient (GO:0015985)2.90662079
107exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90488775
108protein K6-linked ubiquitination (GO:0085020)2.88925909
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87716464
110establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87349445
111protein localization to endoplasmic reticulum (GO:0070972)2.86117121
112cellular protein complex disassembly (GO:0043624)2.85048215
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.84665300
114tRNA metabolic process (GO:0006399)2.83497840
115DNA replication-independent nucleosome organization (GO:0034724)2.83231461
116DNA replication-independent nucleosome assembly (GO:0006336)2.83231461
117viral life cycle (GO:0019058)2.83071122
118tRNA processing (GO:0008033)2.83068463
119RNA methylation (GO:0001510)2.82945380
120mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82041833
121positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81653188
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79964714
123RNA-dependent DNA replication (GO:0006278)2.79261342
124ribosome assembly (GO:0042255)2.79111211
125DNA unwinding involved in DNA replication (GO:0006268)2.77784614
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.76373398
127histone mRNA metabolic process (GO:0008334)2.75557464
128water-soluble vitamin biosynthetic process (GO:0042364)2.75001350
129DNA ligation (GO:0006266)2.74499671
130negative regulation of DNA-dependent DNA replication (GO:2000104)2.74170965
131DNA-templated transcription, elongation (GO:0006354)2.73886392
132transcription initiation from RNA polymerase I promoter (GO:0006361)2.73743565
133negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72555852
134negative regulation of ligase activity (GO:0051352)2.72555852
135telomere maintenance via telomerase (GO:0007004)2.71057436
136regulation of hippo signaling (GO:0035330)2.64272554
137reciprocal DNA recombination (GO:0035825)2.60330487
138reciprocal meiotic recombination (GO:0007131)2.60330487
139transcription from RNA polymerase III promoter (GO:0006383)2.60198852
140negative regulation of telomere maintenance (GO:0032205)2.59193921
141amino acid salvage (GO:0043102)2.59161060
142L-methionine salvage (GO:0071267)2.59161060
143L-methionine biosynthetic process (GO:0071265)2.59161060
144regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.59115215
145regulation of mitotic spindle checkpoint (GO:1903504)2.59115215
146protein targeting to mitochondrion (GO:0006626)2.58735488
147establishment of protein localization to mitochondrion (GO:0072655)2.56182712
148regulation of centrosome cycle (GO:0046605)2.55046391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.50051870
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.60965883
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.31830722
4* EST1_17652178_ChIP-ChIP_JURKAT_Human3.65500738
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.64958733
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.61857799
7* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36702321
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.28365927
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15377425
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.08508489
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.06739666
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.02179587
13* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88675264
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87761481
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.85388682
16* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84635807
17ZNF274_21170338_ChIP-Seq_K562_Hela2.76830900
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68481884
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.66811170
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65266722
21VDR_23849224_ChIP-Seq_CD4+_Human2.53714354
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46876154
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32627454
24XRN2_22483619_ChIP-Seq_HELA_Human2.31092062
25* FOXP3_21729870_ChIP-Seq_TREG_Human2.26101153
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25450066
27DCP1A_22483619_ChIP-Seq_HELA_Human2.23962750
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21014941
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20403600
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20268071
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.19770989
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10549818
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.08065905
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05613075
35VDR_22108803_ChIP-Seq_LS180_Human2.05581916
36* TTF2_22483619_ChIP-Seq_HELA_Human2.05096762
37ELK1_19687146_ChIP-ChIP_HELA_Human2.04244035
38SRF_21415370_ChIP-Seq_HL-1_Mouse2.04195924
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96648717
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95196107
41GABP_19822575_ChIP-Seq_HepG2_Human1.92737006
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88673104
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82691519
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82656124
45* NOTCH1_21737748_ChIP-Seq_TLL_Human1.78428864
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78154089
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73663700
48EWS_26573619_Chip-Seq_HEK293_Human1.70717153
49* E2F1_21310950_ChIP-Seq_MCF-7_Human1.68869196
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65836334
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62069781
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59837481
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59700758
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.53261022
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.52991364
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51627294
57* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49826736
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43709583
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43414757
60* MYC_18940864_ChIP-ChIP_HL60_Human1.41797410
61* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39680971
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33720319
63CIITA_25753668_ChIP-Seq_RAJI_Human1.32706385
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31142530
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.28845522
66IRF1_19129219_ChIP-ChIP_H3396_Human1.28610733
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28475162
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28096139
69TP53_22573176_ChIP-Seq_HFKS_Human1.25927155
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25027262
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16833018
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15886877
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14505143
74* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14186492
75* KDM5A_27292631_Chip-Seq_BREAST_Human1.12839956
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12597998
77* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09318497
78* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08104045
79FUS_26573619_Chip-Seq_HEK293_Human1.07717303
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04575274
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04575274
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04575274
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03092526
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02543648
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99843945
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99481925
87CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95815687
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95163370
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92932283
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91579371
91RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91548653
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91323439
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91068474
94FOXP1_21924763_ChIP-Seq_HESCs_Human0.90672825
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89913330
96AR_21909140_ChIP-Seq_LNCAP_Human0.89890921
97* SPI1_23547873_ChIP-Seq_NB4_Human0.89797488
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89067302
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88755182
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86505767
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86325394
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86078801
103HOXB7_26014856_ChIP-Seq_BT474_Human0.83313424
104ERA_21632823_ChIP-Seq_H3396_Human0.83111706
105TFEB_21752829_ChIP-Seq_HELA_Human0.81504874
106TAF15_26573619_Chip-Seq_HEK293_Human0.81333643
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80786839
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79889291
109RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79123949
110BP1_19119308_ChIP-ChIP_Hs578T_Human0.78590103
111P53_21459846_ChIP-Seq_SAOS-2_Human0.76888246
112FOXA1_25329375_ChIP-Seq_VCAP_Human0.75895603
113FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75895603
114GBX2_23144817_ChIP-Seq_PC3_Human0.75708007
115IGF1R_20145208_ChIP-Seq_DFB_Human0.75097266
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.74958691
117NCOR_22424771_ChIP-Seq_293T_Human0.74901739
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74703117
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.74368498
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.74316825
121FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74218627
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74030012
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.72699793
124IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.72388940
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71987800
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.66300775
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65717345
128* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.64314710
129NANOG_16153702_ChIP-ChIP_HESCs_Human0.62256921
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61771952
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.61770961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.11202544
2MP0008057_abnormal_DNA_replication3.95032278
3MP0010094_abnormal_chromosome_stability3.62484193
4MP0003111_abnormal_nucleus_morphology3.49832412
5MP0008058_abnormal_DNA_repair3.46176093
6MP0006292_abnormal_olfactory_placode3.44073276
7MP0001188_hyperpigmentation3.25803737
8MP0009379_abnormal_foot_pigmentation3.12585895
9MP0004957_abnormal_blastocyst_morpholog3.11871118
10MP0008007_abnormal_cellular_replicative2.83145383
11MP0003077_abnormal_cell_cycle2.82655216
12MP0008932_abnormal_embryonic_tissue2.57661401
13MP0003136_yellow_coat_color2.39752107
14MP0002736_abnormal_nociception_after2.12662199
15MP0000015_abnormal_ear_pigmentation2.07771284
16MP0003941_abnormal_skin_development2.06789465
17MP0005409_darkened_coat_color2.05372589
18MP0002132_abnormal_respiratory_system1.89165083
19MP0001968_abnormal_touch/_nociception1.81704069
20MP0003786_premature_aging1.80537868
21MP0002396_abnormal_hematopoietic_system1.80144317
22MP0002102_abnormal_ear_morphology1.69072143
23MP0008877_abnormal_DNA_methylation1.61168470
24MP0003806_abnormal_nucleotide_metabolis1.57529067
25MP0005174_abnormal_tail_pigmentation1.56905644
26MP0002277_abnormal_respiratory_mucosa1.55260943
27MP0006072_abnormal_retinal_apoptosis1.52594330
28MP0003718_maternal_effect1.51884520
29MP0008875_abnormal_xenobiotic_pharmacok1.49651670
30MP0000490_abnormal_crypts_of1.49172231
31MP0009333_abnormal_splenocyte_physiolog1.48073318
32MP0005551_abnormal_eye_electrophysiolog1.45438951
33MP0000350_abnormal_cell_proliferation1.41662442
34MP0006035_abnormal_mitochondrial_morpho1.41619453
35MP0008872_abnormal_physiological_respon1.37099326
36MP0002160_abnormal_reproductive_system1.34600257
37MP0003119_abnormal_digestive_system1.32370529
38MP0003315_abnormal_perineum_morphology1.31190632
39MP0004043_abnormal_pH_regulation1.28320701
40MP0002234_abnormal_pharynx_morphology1.26840830
41MP0003763_abnormal_thymus_physiology1.25584942
42MP0003123_paternal_imprinting1.25303054
43MP0000566_synostosis1.24959276
44MP0003646_muscle_fatigue1.24919869
45MP0000049_abnormal_middle_ear1.24491415
46MP0000631_abnormal_neuroendocrine_gland1.24013002
47MP0001485_abnormal_pinna_reflex1.22457260
48MP0002095_abnormal_skin_pigmentation1.21379828
49MP0010030_abnormal_orbit_morphology1.20941085
50MP0002163_abnormal_gland_morphology1.16959025
51MP0008789_abnormal_olfactory_epithelium1.16858626
52MP0009046_muscle_twitch1.16565122
53MP0005377_hearing/vestibular/ear_phenot1.15552541
54MP0003878_abnormal_ear_physiology1.15552541
55MP0003890_abnormal_embryonic-extraembry1.14268121
56MP0000427_abnormal_hair_cycle1.12729350
57MP0000313_abnormal_cell_death1.12008686
58MP0001986_abnormal_taste_sensitivity1.11421182
59MP0003195_calcinosis1.07250203
60MP0005645_abnormal_hypothalamus_physiol1.06206772
61MP0004133_heterotaxia1.06040567
62MP0000678_abnormal_parathyroid_gland1.05159448
63MP0009697_abnormal_copulation1.04521372
64MP0002210_abnormal_sex_determination1.04033132
65MP0005389_reproductive_system_phenotype1.02435090
66MP0006036_abnormal_mitochondrial_physio1.01746674
67MP0004142_abnormal_muscle_tone1.01423458
68MP0001730_embryonic_growth_arrest1.00509344
69MP0002653_abnormal_ependyma_morphology0.99958856
70MP0004147_increased_porphyrin_level0.99602718
71MP0005253_abnormal_eye_physiology0.99371754
72MP0005367_renal/urinary_system_phenotyp0.98413224
73MP0000516_abnormal_urinary_system0.98413224
74MP0005075_abnormal_melanosome_morpholog0.96848630
75MP0003121_genomic_imprinting0.96576501
76MP0000647_abnormal_sebaceous_gland0.96016880
77MP0005499_abnormal_olfactory_system0.95609755
78MP0005394_taste/olfaction_phenotype0.95609755
79MP0001119_abnormal_female_reproductive0.95550870
80MP0005380_embryogenesis_phenotype0.94432856
81MP0001672_abnormal_embryogenesis/_devel0.94432856
82MP0000358_abnormal_cell_content/0.94246238
83MP0001835_abnormal_antigen_presentation0.94049664
84MP0001697_abnormal_embryo_size0.92855678
85MP0001529_abnormal_vocalization0.91537449
86MP0005084_abnormal_gallbladder_morpholo0.91294067
87MP0000703_abnormal_thymus_morphology0.90996326
88MP0002938_white_spotting0.90874079
89MP0004381_abnormal_hair_follicle0.88112020
90MP0001919_abnormal_reproductive_system0.87077473
91MP0002085_abnormal_embryonic_tissue0.87056867
92MP0002019_abnormal_tumor_incidence0.86697767
93MP0003698_abnormal_male_reproductive0.84661408
94MP0002148_abnormal_hypersensitivity_rea0.84607573
95MP0002254_reproductive_system_inflammat0.84251939
96MP0009745_abnormal_behavioral_response0.83707224
97MP0001145_abnormal_male_reproductive0.83674302
98MP0002249_abnormal_larynx_morphology0.83174634
99MP0001293_anophthalmia0.82987273
100MP0002177_abnormal_outer_ear0.82735343
101MP0005395_other_phenotype0.82346002
102MP0003283_abnormal_digestive_organ0.81522672
103MP0005646_abnormal_pituitary_gland0.80416559
104MP0005410_abnormal_fertilization0.80171923
105MP0003755_abnormal_palate_morphology0.80046222
106MP0001186_pigmentation_phenotype0.79938958
107MP0006276_abnormal_autonomic_nervous0.79430894
108MP0003011_delayed_dark_adaptation0.79143517
109MP0002751_abnormal_autonomic_nervous0.78965004
110MP0002837_dystrophic_cardiac_calcinosis0.78234552
111MP0002398_abnormal_bone_marrow0.77709724
112MP0001764_abnormal_homeostasis0.77644974
113MP0003938_abnormal_ear_development0.76713834
114MP0002080_prenatal_lethality0.76611480
115MP0000372_irregular_coat_pigmentation0.76341906
116MP0005332_abnormal_amino_acid0.75897583
117MP0000858_altered_metastatic_potential0.73822298
118MP0002638_abnormal_pupillary_reflex0.73447605
119MP0003937_abnormal_limbs/digits/tail_de0.73358696
120MP0005671_abnormal_response_to0.73155598
121MP0003984_embryonic_growth_retardation0.72986397
122MP0004808_abnormal_hematopoietic_stem0.72562145
123MP0001286_abnormal_eye_development0.72198226
124MP0002735_abnormal_chemical_nociception0.71433814
125MP0005257_abnormal_intraocular_pressure0.71311029
126MP0010307_abnormal_tumor_latency0.70471125
127MP0000689_abnormal_spleen_morphology0.70346841
128MP0002722_abnormal_immune_system0.70332987
129MP0000653_abnormal_sex_gland0.69419585
130MP0002272_abnormal_nervous_system0.69210436
131MP0005195_abnormal_posterior_eye0.68928056
132MP0002088_abnormal_embryonic_growth/wei0.68898503
133MP0008995_early_reproductive_senescence0.68482930
134MP0001346_abnormal_lacrimal_gland0.68212168
135MP0004145_abnormal_muscle_electrophysio0.67013360
136MP0002111_abnormal_tail_morphology0.66548728
137MP0009250_abnormal_appendicular_skeleto0.66143785
138MP0003186_abnormal_redox_activity0.65825534
139MP0005171_absent_coat_pigmentation0.65317760
140MP0003787_abnormal_imprinting0.63349971
141MP0002084_abnormal_developmental_patter0.63009584
142MP0002075_abnormal_coat/hair_pigmentati0.61764221
143MP0001929_abnormal_gametogenesis0.61509157
144MP0001542_abnormal_bone_strength0.61040675
145MP0003936_abnormal_reproductive_system0.60498883
146MP0002429_abnormal_blood_cell0.60315125

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.69261935
2Chromsome breakage (HP:0040012)4.48055403
3Reticulocytopenia (HP:0001896)4.23923925
4Birth length less than 3rd percentile (HP:0003561)4.09929051
5Breast hypoplasia (HP:0003187)3.39622781
6Abnormality of the preputium (HP:0100587)3.29863994
7Abnormality of cells of the erythroid lineage (HP:0012130)3.23592412
8Meckel diverticulum (HP:0002245)3.22068262
9Pendular nystagmus (HP:0012043)3.19760362
10Abnormal number of erythroid precursors (HP:0012131)3.12423854
11Congenital stationary night blindness (HP:0007642)3.12163466
12Abnormality of the ileum (HP:0001549)3.10596461
13Pancreatic fibrosis (HP:0100732)2.92221049
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.91597562
15Abnormality of alanine metabolism (HP:0010916)2.91597562
16Hyperalaninemia (HP:0003348)2.91597562
17Absent thumb (HP:0009777)2.91036789
18Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90336877
19Abnormality of chromosome stability (HP:0003220)2.90289625
20Duplicated collecting system (HP:0000081)2.88708906
21Macrocytic anemia (HP:0001972)2.88051204
22Acute encephalopathy (HP:0006846)2.87973223
23Abnormality of midbrain morphology (HP:0002418)2.87907989
24Molar tooth sign on MRI (HP:0002419)2.87907989
25Patellar aplasia (HP:0006443)2.83388478
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.82701051
27Aplastic anemia (HP:0001915)2.82595206
28Triphalangeal thumb (HP:0001199)2.79834347
29Lipid accumulation in hepatocytes (HP:0006561)2.75480492
30Rough bone trabeculation (HP:0100670)2.74123978
31Aplasia/Hypoplasia of the patella (HP:0006498)2.71360053
32Hypoplasia of the pons (HP:0012110)2.70211042
33Oral leukoplakia (HP:0002745)2.69866298
34Supernumerary spleens (HP:0009799)2.69103539
35Absent radius (HP:0003974)2.68180496
36Attenuation of retinal blood vessels (HP:0007843)2.66267159
37Abnormality of the pons (HP:0007361)2.65475643
38True hermaphroditism (HP:0010459)2.61933713
39Abnormality of the renal collecting system (HP:0004742)2.60169812
403-Methylglutaconic aciduria (HP:0003535)2.56870021
41Pallor (HP:0000980)2.55762848
42Horseshoe kidney (HP:0000085)2.52892222
43Aplasia involving forearm bones (HP:0009822)2.49740442
44Absent forearm bone (HP:0003953)2.49740442
45Bone marrow hypocellularity (HP:0005528)2.48387688
46Premature graying of hair (HP:0002216)2.45586793
47Bilateral microphthalmos (HP:0007633)2.44720136
48Cerebral hypomyelination (HP:0006808)2.44675057
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.41807002
50Rib fusion (HP:0000902)2.41592893
51Mitochondrial inheritance (HP:0001427)2.40778150
52Type II lissencephaly (HP:0007260)2.39485186
53Ectopic kidney (HP:0000086)2.38349584
54Hepatic necrosis (HP:0002605)2.33885528
55Colon cancer (HP:0003003)2.32012280
56Methylmalonic aciduria (HP:0012120)2.31413067
57Type I transferrin isoform profile (HP:0003642)2.30053325
58Acute necrotizing encephalopathy (HP:0006965)2.29181034
59Abnormality of the labia minora (HP:0012880)2.29079959
60Sclerocornea (HP:0000647)2.28570537
61Microvesicular hepatic steatosis (HP:0001414)2.26207034
62Carpal bone hypoplasia (HP:0001498)2.24498863
63Cleft eyelid (HP:0000625)2.24142346
64Pancytopenia (HP:0001876)2.23931934
65Exertional dyspnea (HP:0002875)2.23379389
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23326013
67Nephronophthisis (HP:0000090)2.21909968
68Myelodysplasia (HP:0002863)2.21843347
69Hepatocellular necrosis (HP:0001404)2.20445229
70Testicular atrophy (HP:0000029)2.17579649
71Increased CSF lactate (HP:0002490)2.16641176
72Type 2 muscle fiber atrophy (HP:0003554)2.15695195
73Clubbing of toes (HP:0100760)2.15153436
74Increased serum lactate (HP:0002151)2.15143839
75Small intestinal stenosis (HP:0012848)2.14920615
76Duodenal stenosis (HP:0100867)2.14920615
77Abnormality of DNA repair (HP:0003254)2.14366663
78Increased hepatocellular lipid droplets (HP:0006565)2.13337917
79Abnormality of the anterior horn cell (HP:0006802)2.12877462
80Degeneration of anterior horn cells (HP:0002398)2.12877462
81Bony spicule pigmentary retinopathy (HP:0007737)2.12684095
82Abnormal protein glycosylation (HP:0012346)2.11410942
83Abnormal glycosylation (HP:0012345)2.11410942
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11410942
85Abnormal protein N-linked glycosylation (HP:0012347)2.11410942
86Abnormal trabecular bone morphology (HP:0100671)2.11093761
87Abnormal lung lobation (HP:0002101)2.10973054
88Sparse eyelashes (HP:0000653)2.07751372
89Lactic acidosis (HP:0003128)2.07427697
90Poikiloderma (HP:0001029)2.04640819
91Duplication of thumb phalanx (HP:0009942)2.03466534
92Abnormal number of incisors (HP:0011064)2.02932660
93Methylmalonic acidemia (HP:0002912)2.01510085
94Muscle fiber atrophy (HP:0100295)1.99827047
95Tracheoesophageal fistula (HP:0002575)1.99319686
96Asplenia (HP:0001746)1.97046819
97Selective tooth agenesis (HP:0001592)1.96630529
98Short thumb (HP:0009778)1.95430701
99Congenital, generalized hypertrichosis (HP:0004540)1.95019964
100Trismus (HP:0000211)1.94262533
101Adrenal hypoplasia (HP:0000835)1.93846885
102Cerebral edema (HP:0002181)1.92729020
103Small hand (HP:0200055)1.91806165
104Hyperglycinuria (HP:0003108)1.91217938
105Abnormal mitochondria in muscle tissue (HP:0008316)1.90929916
106Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.90079788
107Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89613386
108Abnormality of serum amino acid levels (HP:0003112)1.89246691
109Concave nail (HP:0001598)1.89123795
110Agnosia (HP:0010524)1.87654696
111Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87371509
112Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87371509
113Optic disc pallor (HP:0000543)1.86792583
114Hypoplasia of the radius (HP:0002984)1.83446742
115Aplasia/Hypoplasia of the spleen (HP:0010451)1.81604379
116Progressive inability to walk (HP:0002505)1.79952354
117Cystic liver disease (HP:0006706)1.79863734
118Increased intramyocellular lipid droplets (HP:0012240)1.79513431
119Cerebellar dysplasia (HP:0007033)1.78671512
120Severe visual impairment (HP:0001141)1.78621188
121Exercise intolerance (HP:0003546)1.78412352
122Sloping forehead (HP:0000340)1.78038988
123Abnormality of the renal medulla (HP:0100957)1.77864524
124Prostate neoplasm (HP:0100787)1.76916730
125Progressive external ophthalmoplegia (HP:0000590)1.76816966
126Septo-optic dysplasia (HP:0100842)1.76530655
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.76094411
128Abnormality of the duodenum (HP:0002246)1.75957663
129Abnormality of the carotid arteries (HP:0005344)1.75420550
130Facial cleft (HP:0002006)1.75280327
131Progressive macrocephaly (HP:0004481)1.73599775
132Abnormal biliary tract physiology (HP:0012439)1.72293752
133Bile duct proliferation (HP:0001408)1.72293752
134Renal Fanconi syndrome (HP:0001994)1.71976246
135Abnormality of the renal cortex (HP:0011035)1.71918102
136Chronic hepatic failure (HP:0100626)1.71671680
137Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71442201
138Lissencephaly (HP:0001339)1.69350925
139Neoplasm of the pancreas (HP:0002894)1.69328018
140Pancreatic cysts (HP:0001737)1.69156302
141Inability to walk (HP:0002540)1.68144444
142Cellular immunodeficiency (HP:0005374)1.65935647
143Unsteady gait (HP:0002317)1.65588888
144Lymphoma (HP:0002665)1.64757344
145Secondary amenorrhea (HP:0000869)1.64081633
146Impulsivity (HP:0100710)1.63267687
147Aplasia/hypoplasia of the uterus (HP:0008684)1.61953965
148Microretrognathia (HP:0000308)1.61777259
149Preaxial hand polydactyly (HP:0001177)1.61220801
150Reduced antithrombin III activity (HP:0001976)1.60822648
151Tetralogy of Fallot (HP:0001636)1.60189368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.97687973
2EIF2AK13.70270642
3FRK3.65989752
4SRPK13.44012550
5BUB13.40363812
6MKNK23.25389689
7STK163.16772064
8TLK13.09535960
9NME22.91354372
10MKNK12.77145468
11CDC72.61605184
12WEE12.48378164
13WNK32.36100179
14PLK42.31602534
15ZAK2.26395217
16EIF2AK32.25915859
17TSSK62.09017838
18CASK1.95848453
19VRK11.92745973
20PIM21.82038386
21WNK41.77419809
22IRAK31.72920780
23PLK11.62128037
24CDK81.62019964
25TAF11.61208578
26EIF2AK21.60646303
27INSRR1.60268311
28TTK1.58831624
29NEK11.57008395
30BCKDK1.43843534
31STK38L1.43587654
32MAP4K21.43570002
33CDK71.43114195
34YES11.41224205
35CLK11.40810084
36AKT31.39885497
37PLK31.39768068
38IRAK41.35346900
39ATR1.33956045
40PBK1.33788222
41TRIM281.22544077
42NME11.22263397
43TXK1.19518697
44AURKB1.17167464
45AURKA1.14729287
46BLK1.14098326
47DYRK31.13453038
48CHEK21.09143633
49EPHA21.06625717
50CCNB11.06151404
51OXSR11.03265051
52FLT30.98311109
53MAP3K110.97172581
54BRAF0.97099950
55NEK20.91722253
56BMPR20.91692316
57NEK60.90259115
58NEK90.88892139
59STK390.87540684
60TESK20.83953046
61BMPR1B0.83477295
62BRSK20.83458325
63PASK0.83417565
64TNIK0.80760552
65ACVR1B0.80194605
66CSNK2A10.79222867
67CHEK10.79096321
68DYRK20.78276862
69PRPF4B0.75022980
70ADRBK10.73675637
71STK240.70838522
72ADRBK20.69416352
73CSNK2A20.68715966
74ATM0.68135226
75MAPKAPK30.67786002
76MAPKAPK50.65632334
77STK40.65155642
78TEC0.63950112
79CSNK1G10.63173384
80IKBKB0.62725706
81MAP2K70.60591699
82MAPK150.60389526
83PIM10.60284086
84CDK20.59886962
85MAPK130.59418236
86RPS6KA50.58751450
87MAP3K140.58367578
88CSNK1G30.56211185
89PHKG10.54706603
90PHKG20.54706603
91RPS6KA40.53707750
92RPS6KB20.53099797
93TAOK20.52438114
94PDK20.51854954
95PRKCG0.51643471
96ERBB30.51002278
97BRSK10.50991393
98MAP3K120.50809490
99CSNK1E0.50446926
100CDK30.49045827
101PRKCI0.48823444
102STK30.48432206
103PAK10.47930971
104CDK40.44209561
105CSNK1G20.43509982
106MAP3K40.43178650
107LYN0.42564491
108* CDK10.42043704
109MAP3K80.41355079
110PNCK0.41297190
111CSNK1A1L0.40450576
112MUSK0.39171492
113PLK20.38623392
114GRK70.38536249
115BRD40.37752463
116CSNK1A10.37736767
117ERBB40.37575038
118ABL20.35267023
119KDR0.34892260
120ALK0.34034471
121BTK0.33049336
122AKT20.32289354
123MAP3K30.31898991
124GRK10.31594997
125NUAK10.31490922
126NLK0.31372657
127CDK190.31074268
128PRKDC0.30828647
129PRKCE0.30469968
130SMG10.29496538
131CSNK1D0.28638049
132MST40.27856068
133MAP2K30.27340317
134PINK10.25938743
135TGFBR10.24628738
136LCK0.24261130
137RPS6KB10.23933815
138DAPK30.23247890

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.00720632
2DNA replication_Homo sapiens_hsa030303.91154214
3Ribosome_Homo sapiens_hsa030103.87297850
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53805909
5Mismatch repair_Homo sapiens_hsa034303.53507563
6Proteasome_Homo sapiens_hsa030503.19283207
7Homologous recombination_Homo sapiens_hsa034403.00224951
8Spliceosome_Homo sapiens_hsa030402.99617906
9Base excision repair_Homo sapiens_hsa034102.71264638
10Pyrimidine metabolism_Homo sapiens_hsa002402.52156813
11Fanconi anemia pathway_Homo sapiens_hsa034602.49933144
12Nucleotide excision repair_Homo sapiens_hsa034202.49310023
13RNA transport_Homo sapiens_hsa030132.44458474
14One carbon pool by folate_Homo sapiens_hsa006702.25188781
15Selenocompound metabolism_Homo sapiens_hsa004502.24914014
16Basal transcription factors_Homo sapiens_hsa030222.10586055
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01690565
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01664533
19Non-homologous end-joining_Homo sapiens_hsa034501.91053790
20Cell cycle_Homo sapiens_hsa041101.90326003
21RNA degradation_Homo sapiens_hsa030181.83058851
22Protein export_Homo sapiens_hsa030601.66588693
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53630189
24Purine metabolism_Homo sapiens_hsa002301.50332005
25mRNA surveillance pathway_Homo sapiens_hsa030151.49938579
26Oxidative phosphorylation_Homo sapiens_hsa001901.47898671
27Parkinsons disease_Homo sapiens_hsa050121.34479421
28Huntingtons disease_Homo sapiens_hsa050161.26821570
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21877227
30p53 signaling pathway_Homo sapiens_hsa041151.18250876
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08618831
32Nitrogen metabolism_Homo sapiens_hsa009101.06661485
33Butanoate metabolism_Homo sapiens_hsa006501.06091100
34Epstein-Barr virus infection_Homo sapiens_hsa051691.06011868
35Propanoate metabolism_Homo sapiens_hsa006401.05869199
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03049070
37Pyruvate metabolism_Homo sapiens_hsa006200.92981131
38Allograft rejection_Homo sapiens_hsa053300.92496109
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91293692
40Herpes simplex infection_Homo sapiens_hsa051680.90209700
41Tryptophan metabolism_Homo sapiens_hsa003800.88897815
42Arachidonic acid metabolism_Homo sapiens_hsa005900.87584178
43Graft-versus-host disease_Homo sapiens_hsa053320.85830476
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84583598
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82517467
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.81674423
47Nicotine addiction_Homo sapiens_hsa050330.81488518
48Alzheimers disease_Homo sapiens_hsa050100.80423213
49Autoimmune thyroid disease_Homo sapiens_hsa053200.78523491
50Steroid biosynthesis_Homo sapiens_hsa001000.75566155
51Sulfur relay system_Homo sapiens_hsa041220.74209632
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73344736
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70271394
54Primary immunodeficiency_Homo sapiens_hsa053400.68879748
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68421875
56Taste transduction_Homo sapiens_hsa047420.67656059
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.62372025
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61752159
59Measles_Homo sapiens_hsa051620.61164242
60Systemic lupus erythematosus_Homo sapiens_hsa053220.59875841
61Asthma_Homo sapiens_hsa053100.59357785
62Lysine degradation_Homo sapiens_hsa003100.59148106
63Vitamin digestion and absorption_Homo sapiens_hsa049770.57705367
64Sulfur metabolism_Homo sapiens_hsa009200.57479716
65Ether lipid metabolism_Homo sapiens_hsa005650.56630390
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.56166964
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55400265
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.54432019
69Peroxisome_Homo sapiens_hsa041460.54424805
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52712423
71Legionellosis_Homo sapiens_hsa051340.52144507
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.51798442
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51118149
74HTLV-I infection_Homo sapiens_hsa051660.51069021
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50780546
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48603612
77N-Glycan biosynthesis_Homo sapiens_hsa005100.47654701
78Antigen processing and presentation_Homo sapiens_hsa046120.44573560
79Folate biosynthesis_Homo sapiens_hsa007900.44563549
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44540723
81Type I diabetes mellitus_Homo sapiens_hsa049400.44125544
82Hematopoietic cell lineage_Homo sapiens_hsa046400.43762708
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42250075
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41906161
85Viral carcinogenesis_Homo sapiens_hsa052030.41413049
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40983687
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40916833
88Basal cell carcinoma_Homo sapiens_hsa052170.40017535
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39737466
90Olfactory transduction_Homo sapiens_hsa047400.39460491
91Sphingolipid metabolism_Homo sapiens_hsa006000.39310689
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38869525
93Other glycan degradation_Homo sapiens_hsa005110.38790504
94Vitamin B6 metabolism_Homo sapiens_hsa007500.38758169
95beta-Alanine metabolism_Homo sapiens_hsa004100.37422588
96Apoptosis_Homo sapiens_hsa042100.37042035
97Oocyte meiosis_Homo sapiens_hsa041140.36561614
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36215659
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36050549
100Chemical carcinogenesis_Homo sapiens_hsa052040.35936462
101Thyroid cancer_Homo sapiens_hsa052160.35585773
102Caffeine metabolism_Homo sapiens_hsa002320.35485959
103Biosynthesis of amino acids_Homo sapiens_hsa012300.35391215
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34740150
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34276232
106Arginine and proline metabolism_Homo sapiens_hsa003300.32364168
107Linoleic acid metabolism_Homo sapiens_hsa005910.31927809
108Retinol metabolism_Homo sapiens_hsa008300.31809413
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31394758
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31351276
111Phototransduction_Homo sapiens_hsa047440.30645889
112Hepatitis B_Homo sapiens_hsa051610.29650153
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28888344
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.28620649
115Rheumatoid arthritis_Homo sapiens_hsa053230.28445724
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28438450
117Influenza A_Homo sapiens_hsa051640.27763677
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27110234
119Metabolic pathways_Homo sapiens_hsa011000.27011300
120Glycerolipid metabolism_Homo sapiens_hsa005610.26937216
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.26893850
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26811465
123Fatty acid biosynthesis_Homo sapiens_hsa000610.26264342
124TGF-beta signaling pathway_Homo sapiens_hsa043500.25769401
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25495867
126Melanoma_Homo sapiens_hsa052180.25037007
127MicroRNAs in cancer_Homo sapiens_hsa052060.22510402
128Wnt signaling pathway_Homo sapiens_hsa043100.22261692
129Fat digestion and absorption_Homo sapiens_hsa049750.21880105
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20811328
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20803074
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20297159
133Leishmaniasis_Homo sapiens_hsa051400.19858697
134Alcoholism_Homo sapiens_hsa050340.19733483
135Shigellosis_Homo sapiens_hsa051310.19723230
136Glutathione metabolism_Homo sapiens_hsa004800.19556975
137Cardiac muscle contraction_Homo sapiens_hsa042600.18587077
138Pentose phosphate pathway_Homo sapiens_hsa000300.18067315
139Hippo signaling pathway_Homo sapiens_hsa043900.17420463
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.17098763
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.16392642
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15956603
143Hedgehog signaling pathway_Homo sapiens_hsa043400.15692358
144Pathways in cancer_Homo sapiens_hsa052000.15148147

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