CD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)9.17154876
2positive T cell selection (GO:0043368)8.06105193
3negative thymic T cell selection (GO:0045060)8.01326602
4regulation of gamma-delta T cell differentiation (GO:0045586)7.74766769
5positive regulation of gamma-delta T cell activation (GO:0046645)7.74163995
6regulation of gamma-delta T cell activation (GO:0046643)7.00142604
7* T cell selection (GO:0045058)6.82000351
8thymic T cell selection (GO:0045061)6.77276148
9negative regulation of cell killing (GO:0031342)6.75138420
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.75138420
11positive thymic T cell selection (GO:0045059)6.73467341
12tolerance induction (GO:0002507)6.47794092
13interferon-gamma production (GO:0032609)6.37982225
14regulation of isotype switching to IgG isotypes (GO:0048302)6.22516416
15activated T cell proliferation (GO:0050798)6.05922930
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.03693134
17* positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.99481068
18negative regulation of thymocyte apoptotic process (GO:0070244)5.97561761
19response to interleukin-15 (GO:0070672)5.97165058
20regulation of T cell tolerance induction (GO:0002664)5.75843748
21V(D)J recombination (GO:0033151)5.72617269
22* T cell receptor signaling pathway (GO:0050852)5.62961454
23regulation of regulatory T cell differentiation (GO:0045589)5.31020558
24cellular response to interleukin-15 (GO:0071350)5.28494385
25alpha-beta T cell differentiation (GO:0046632)5.07665667
26* T cell costimulation (GO:0031295)5.04800731
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.04186748
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.04186748
29neutrophil activation involved in immune response (GO:0002283)5.00107736
30* regulation of interleukin-2 biosynthetic process (GO:0045076)4.99466836
31* lymphocyte costimulation (GO:0031294)4.98658071
32alpha-beta T cell activation (GO:0046631)4.92179013
33negative regulation of interleukin-12 production (GO:0032695)4.87144020
34response to peptidoglycan (GO:0032494)4.68326312
35positive regulation of tolerance induction (GO:0002645)4.64300455
36* positive regulation of interleukin-2 production (GO:0032743)4.58535665
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.56532425
38* antigen receptor-mediated signaling pathway (GO:0050851)4.50489211
39leukocyte aggregation (GO:0070486)4.44060629
40positive regulation by symbiont of host defense response (GO:0052509)4.43593192
41modulation by symbiont of host defense response (GO:0052031)4.43593192
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.43593192
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.43593192
44positive regulation by organism of defense response of other organism involved in symbiotic interact4.43593192
45modulation by symbiont of host immune response (GO:0052553)4.43593192
46antigen processing and presentation of endogenous antigen (GO:0019883)4.35225414
47macrophage activation involved in immune response (GO:0002281)4.34486216
48regulation of thymocyte apoptotic process (GO:0070243)4.25081043
49T cell migration (GO:0072678)4.24403374
50* T cell differentiation (GO:0030217)4.24281653
51detection of other organism (GO:0098543)4.16495145
52regulation of alpha-beta T cell proliferation (GO:0046640)4.16338819
53immunoglobulin mediated immune response (GO:0016064)4.11931146
54regulation of tolerance induction (GO:0002643)4.08784506
55regulation of T cell receptor signaling pathway (GO:0050856)4.08722888
56detection of bacterium (GO:0016045)4.00103155
57negative regulation of T cell mediated immunity (GO:0002710)3.94541555
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.88003122
59regulation of isotype switching (GO:0045191)3.85055575
60mast cell activation (GO:0045576)3.84791771
61positive regulation of alpha-beta T cell proliferation (GO:0046641)3.84312541
62cellular extravasation (GO:0045123)3.82308144
63positive regulation of isotype switching (GO:0045830)3.78021387
64* regulation of interleukin-2 production (GO:0032663)3.76458055
65T cell homeostasis (GO:0043029)3.75787146
66CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.75678626
67Peyers patch development (GO:0048541)3.68899854
68mucosal-associated lymphoid tissue development (GO:0048537)3.68899854
69regulation of interleukin-12 biosynthetic process (GO:0045075)3.63460875
70CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.55791833
71T-helper cell differentiation (GO:0042093)3.55791833
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.53169740
73granulocyte activation (GO:0036230)3.51950257
74detection of external biotic stimulus (GO:0098581)3.50669733
75response to muramyl dipeptide (GO:0032495)3.50101779
76regulation of B cell receptor signaling pathway (GO:0050855)3.49305125
77* T cell activation (GO:0042110)3.48496966
78neutrophil activation (GO:0042119)3.44409105
79regulation of mast cell degranulation (GO:0043304)3.41057558
80negative regulation of T cell apoptotic process (GO:0070233)3.40136149
81myeloid cell activation involved in immune response (GO:0002275)3.40092242
82interferon-gamma-mediated signaling pathway (GO:0060333)3.39595036
83CD4-positive, alpha-beta T cell activation (GO:0035710)3.39043680
84regulation of dendritic cell antigen processing and presentation (GO:0002604)3.37011856
85mast cell activation involved in immune response (GO:0002279)3.34175030
86mast cell degranulation (GO:0043303)3.34175030
87T cell proliferation (GO:0042098)3.32528742
88regulation of interferon-beta biosynthetic process (GO:0045357)3.32518117
89positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.31479300
90positive regulation of natural killer cell mediated immunity (GO:0002717)3.31479300
91detection of molecule of bacterial origin (GO:0032490)3.31324438
92JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.30367948
93lymphocyte homeostasis (GO:0002260)3.29508472
94lipopolysaccharide-mediated signaling pathway (GO:0031663)3.28837356
95positive regulation of antigen processing and presentation (GO:0002579)3.28518806
96negative regulation of cytokine production involved in immune response (GO:0002719)3.27371659
97myeloid dendritic cell differentiation (GO:0043011)3.26829224
98regulation of immunoglobulin production (GO:0002637)3.26704867
99positive regulation of mast cell activation (GO:0033005)3.26109275
100germinal center formation (GO:0002467)3.25424211
101regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.24302811
102regulation of natural killer cell mediated immunity (GO:0002715)3.24302811
103regulation of chronic inflammatory response (GO:0002676)3.23412649
104alpha-beta T cell differentiation involved in immune response (GO:0002293)3.22968080
105alpha-beta T cell activation involved in immune response (GO:0002287)3.22968080
106T cell differentiation involved in immune response (GO:0002292)3.22968080
107type I interferon signaling pathway (GO:0060337)3.21495668
108cellular response to type I interferon (GO:0071357)3.21495668
109positive regulation of T cell differentiation (GO:0045582)3.21295575
110regulation of antigen processing and presentation (GO:0002577)3.21057453
111NIK/NF-kappaB signaling (GO:0038061)3.20439512
112response to type I interferon (GO:0034340)3.18303228
113positive regulation of DNA recombination (GO:0045911)3.17769798
114* positive regulation of T cell activation (GO:0050870)3.16840791
115positive regulation of granulocyte differentiation (GO:0030854)3.16616664
116myeloid dendritic cell activation (GO:0001773)3.15990290
117macrophage activation (GO:0042116)3.14213320
118respiratory burst (GO:0045730)3.14140903
119negative regulation of erythrocyte differentiation (GO:0045647)3.13754971
120regulation of T cell differentiation (GO:0045580)3.13078516
121detection of biotic stimulus (GO:0009595)3.13016374
122positive regulation of humoral immune response (GO:0002922)3.12886161
123T cell lineage commitment (GO:0002360)3.12780396
124negative regulation of leukocyte mediated immunity (GO:0002704)3.11857782
125regulation of mast cell activation involved in immune response (GO:0033006)3.11104651
126* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.11013885
127regulation of response to interferon-gamma (GO:0060330)3.09478213
128regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.09219324
129B cell mediated immunity (GO:0019724)3.09013449
130negative regulation of lymphocyte mediated immunity (GO:0002707)3.08839315
131microglial cell activation (GO:0001774)3.07609752
132regulation of myeloid leukocyte mediated immunity (GO:0002886)3.04231054
133regulation of leukocyte degranulation (GO:0043300)3.04151340
134positive regulation of natural killer cell differentiation (GO:0032825)3.02210771
135positive regulation of mast cell degranulation (GO:0043306)3.01432916
136positive regulation of mast cell activation involved in immune response (GO:0033008)3.01432916
137defense response to protozoan (GO:0042832)3.00501542
138regulation of immunoglobulin mediated immune response (GO:0002889)3.00425645
139positive regulation of interleukin-4 production (GO:0032753)3.00420897
140negative regulation of T cell receptor signaling pathway (GO:0050860)2.99968958
141positive regulation of immunoglobulin production (GO:0002639)2.99814882
142regulation of alpha-beta T cell activation (GO:0046634)2.99675535
143positive regulation of B cell differentiation (GO:0045579)2.99515697
144* lymphocyte differentiation (GO:0030098)2.99358707
145regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.96083064
146regulation of mast cell activation (GO:0033003)2.95919830
147cellular response to interleukin-4 (GO:0071353)2.95326518
148T-helper 1 type immune response (GO:0042088)2.95291721
149regulation of B cell differentiation (GO:0045577)2.95170135
150natural killer cell activation (GO:0030101)2.94909030
151somatic cell DNA recombination (GO:0016444)2.93992675
152somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.93992675
153response to protozoan (GO:0001562)2.91130229
154response to host immune response (GO:0052572)2.89056112
155response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.89056112
156positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85611531
157amino sugar catabolic process (GO:0046348)2.85300568
158positive regulation of cellular amide metabolic process (GO:0034250)2.81982498
159negative regulation of interleukin-6 production (GO:0032715)2.79802912
160regulation of interferon-alpha production (GO:0032647)2.78200962
161glycosphingolipid catabolic process (GO:0046479)2.76179394
162cellular response to thyroid hormone stimulus (GO:0097067)2.75587689
163myeloid leukocyte activation (GO:0002274)2.75087969
164negative regulation of innate immune response (GO:0045824)2.72156676
165regulation of T-helper 2 cell differentiation (GO:0045628)2.72116818
166mannose metabolic process (GO:0006013)2.69496815
167negative regulation of production of molecular mediator of immune response (GO:0002701)2.68080433
168positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.66893566
169positive regulation of type 2 immune response (GO:0002830)2.66465942
170leukocyte degranulation (GO:0043299)2.64346398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.03652048
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.82805414
3RUNX_20019798_ChIP-Seq_JUKART_Human4.13399654
4MYC_22102868_ChIP-Seq_BL_Human4.12064624
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.93853925
6* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.84149243
7E2F7_22180533_ChIP-Seq_HELA_Human3.77018714
8MYB_26560356_Chip-Seq_TH2_Human3.56678353
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.51612848
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.19722841
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.11005942
12MAF_26560356_Chip-Seq_TH1_Human3.08014533
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06508039
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.04523704
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.99091567
16UTX_26944678_Chip-Seq_JUKART_Human2.91894300
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86482896
18* MYB_26560356_Chip-Seq_TH1_Human2.77485284
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.71413352
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.50905231
21VDR_21846776_ChIP-Seq_THP-1_Human2.48602555
22TCF7_22412390_ChIP-Seq_EML_Mouse2.48174120
23* GATA3_27048872_Chip-Seq_THYMUS_Human2.31717974
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.28012633
25KDM2B_26808549_Chip-Seq_DND41_Human2.14324486
26* MAF_26560356_Chip-Seq_TH2_Human2.13830964
27SCL_19346495_ChIP-Seq_HPC-7_Human2.11442938
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.08032212
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04182457
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.92754301
31* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90804473
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.86235374
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85209180
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83152828
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75425943
36VDR_24763502_ChIP-Seq_THP-1_Human1.74785177
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71768150
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67992420
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61448489
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.58880812
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54470522
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53882278
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.49646052
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.49618369
45CIITA_25753668_ChIP-Seq_RAJI_Human1.49526064
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.47366943
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47293797
48SPI1_23547873_ChIP-Seq_NB4_Human1.43251630
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42053422
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.41562921
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39802101
52PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34720860
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33293742
54* SPI1_23127762_ChIP-Seq_K562_Human1.31940237
55CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30687046
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28947652
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26235414
58* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23659138
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21736993
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20830195
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.19602823
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.16029060
63* GATA3_26560356_Chip-Seq_TH2_Human1.14409037
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12539806
65GATA1_22025678_ChIP-Seq_K562_Human1.12119863
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11342806
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10904266
68PU_27001747_Chip-Seq_BMDM_Mouse1.10598146
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09908510
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07000233
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04662925
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01117536
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.01055564
74NCOR1_26117541_ChIP-Seq_K562_Human0.99445640
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98877369
76E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98452099
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.98309375
78* BCL6_27268052_Chip-Seq_Bcells_Human0.97698176
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96255735
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95854682
81* BCOR_27268052_Chip-Seq_Bcells_Human0.92328113
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90589544
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90393298
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89009624
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88616103
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88141715
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87434430
88STAT1_20625510_ChIP-Seq_HELA_Human0.84980669
89PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84307172
90ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83679489
91STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83265951
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.81831437
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81487099
94TFEB_21752829_ChIP-Seq_HELA_Human0.81315772
95CTCF_27219007_Chip-Seq_ERYTHROID_Human0.79683138
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79011589
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.78487882
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76342455
99SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.75931997
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.75779045
101ZFP281_27345836_Chip-Seq_ESCs_Mouse0.75570907
102TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74880900
103RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74829145
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.73556482
105GATA1_19941826_ChIP-Seq_K562_Human0.72391078
106CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71275306
107PU.1_20513432_ChIP-Seq_Bcells_Mouse0.70074284
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.69159737
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68858453
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.68684133
111FOXP3_21729870_ChIP-Seq_TREG_Human0.68192013
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68025801
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.67330566
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66748028
115GATA2_19941826_ChIP-Seq_K562_Human0.66713471
116* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66322714
117VDR_24787735_ChIP-Seq_THP-1_Human0.66145234
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65139851
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.63774354
120TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.63743938
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.63596389
122RUNX1_27514584_Chip-Seq_MCF-7_Human0.63185731
123HIF1A_21447827_ChIP-Seq_MCF-7_Human0.62468738
124LXR_22292898_ChIP-Seq_THP-1_Human0.62314958
125PKCTHETA_26484144_Chip-Seq_BREAST_Human0.61625706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.24169836
2MP0005671_abnormal_response_to4.53674410
3MP0000685_abnormal_immune_system3.60609518
4MP0002166_altered_tumor_susceptibility3.52415888
5* MP0000703_abnormal_thymus_morphology3.20041548
6MP0005058_abnormal_lysosome_morphology3.12244485
7MP0005387_immune_system_phenotype3.04393033
8MP0001790_abnormal_immune_system3.04393033
9MP0001800_abnormal_humoral_immune3.00811631
10MP0001835_abnormal_antigen_presentation2.92115398
11MP0009333_abnormal_splenocyte_physiolog2.91709499
12MP0002006_tumorigenesis2.83050619
13MP0003300_gastrointestinal_ulcer2.80344707
14MP0002398_abnormal_bone_marrow2.79358029
15MP0005000_abnormal_immune_tolerance2.77274500
16MP0004947_skin_inflammation2.56147460
17MP0002420_abnormal_adaptive_immunity2.54931305
18MP0002405_respiratory_system_inflammati2.51722456
19* MP0002723_abnormal_immune_serum2.51670135
20MP0001819_abnormal_immune_cell2.51144494
21MP0003172_abnormal_lysosome_physiology2.39511396
22MP0002722_abnormal_immune_system2.39192009
23MP0000716_abnormal_immune_system2.38086024
24MP0009785_altered_susceptibility_to2.32090862
25* MP0010155_abnormal_intestine_physiology2.31229429
26MP0002933_joint_inflammation2.29720857
27MP0002452_abnormal_antigen_presenting2.25060050
28MP0003866_abnormal_defecation2.24430760
29MP0001873_stomach_inflammation2.15397524
30* MP0000689_abnormal_spleen_morphology2.15092433
31MP0003436_decreased_susceptibility_to2.14564722
32MP0003303_peritoneal_inflammation2.14134653
33MP0002396_abnormal_hematopoietic_system2.13145076
34MP0005025_abnormal_response_to2.00372615
35MP0003191_abnormal_cellular_cholesterol1.89733108
36MP0002429_abnormal_blood_cell1.89660618
37MP0009840_abnormal_foam_cell1.89641647
38MP0002132_abnormal_respiratory_system1.88262812
39MP0004808_abnormal_hematopoietic_stem1.82159365
40MP0002148_abnormal_hypersensitivity_rea1.76038930
41MP0003075_altered_response_to1.71649403
42MP0000604_amyloidosis1.64144184
43MP0005451_abnormal_body_composition1.61572642
44MP0004510_myositis1.61315594
45MP0003724_increased_susceptibility_to1.60957793
46MP0000343_altered_response_to1.57434478
47MP0001845_abnormal_inflammatory_respons1.57352552
48MP0001853_heart_inflammation1.51791182
49MP0008961_abnormal_basal_metabolism1.51295273
50MP0002822_catalepsy1.49904289
51MP0005310_abnormal_salivary_gland1.47964747
52MP0003828_pulmonary_edema1.46671990
53MP0003690_abnormal_glial_cell1.45077338
54MP0002419_abnormal_innate_immunity1.38648880
55MP0008260_abnormal_autophagy1.35078048
56MP0008004_abnormal_stomach_pH1.31579158
57MP0005464_abnormal_platelet_physiology1.30457098
58MP0001545_abnormal_hematopoietic_system1.30267351
59MP0005397_hematopoietic_system_phenotyp1.30267351
60MP0005409_darkened_coat_color1.29725168
61MP0009278_abnormal_bone_marrow1.28547472
62MP0005166_decreased_susceptibility_to1.27584950
63MP0000490_abnormal_crypts_of1.22090337
64MP0002139_abnormal_hepatobiliary_system1.21280905
65MP0004381_abnormal_hair_follicle1.19076331
66MP0000465_gastrointestinal_hemorrhage1.18043696
67MP0001849_ear_inflammation1.16772691
68MP0010352_gastrointestinal_tract_polyps1.15992171
69MP0002009_preneoplasia1.15943599
70MP0005076_abnormal_cell_differentiation1.11240781
71MP0000858_altered_metastatic_potential1.07542249
72MP0004883_abnormal_blood_vessel1.06271773
73MP0008057_abnormal_DNA_replication1.05543156
74MP0005167_abnormal_blood-brain_barrier1.00909281
75MP0002998_abnormal_bone_remodeling0.97692592
76MP0010094_abnormal_chromosome_stability0.97052358
77MP0005075_abnormal_melanosome_morpholog0.96994884
78MP0003806_abnormal_nucleotide_metabolis0.96504653
79MP0003183_abnormal_peptide_metabolism0.96452357
80MP0001851_eye_inflammation0.96414188
81MP0005164_abnormal_response_to0.94595921
82MP0005390_skeleton_phenotype0.92516770
83MP0003787_abnormal_imprinting0.91936019
84MP0002019_abnormal_tumor_incidence0.91893847
85MP0003656_abnormal_erythrocyte_physiolo0.90359791
86MP0002254_reproductive_system_inflammat0.87291631
87MP0005174_abnormal_tail_pigmentation0.84953206
88MP0003448_altered_tumor_morphology0.84848954
89* MP0006082_CNS_inflammation0.83773634
90MP0001533_abnormal_skeleton_physiology0.83665291
91MP0008469_abnormal_protein_level0.83230641
92MP0005023_abnormal_wound_healing0.72688909
93MP0001243_abnormal_dermal_layer0.71435652
94MP0000015_abnormal_ear_pigmentation0.71324570
95MP0003329_amyloid_beta_deposits0.71059248
96MP0002277_abnormal_respiratory_mucosa0.70783656
97MP0001542_abnormal_bone_strength0.67782479
98MP0008569_lethality_at_weaning0.67463296
99MP0003077_abnormal_cell_cycle0.66855323
100* MP0000920_abnormal_myelination0.66348684
101MP0006054_spinal_hemorrhage0.62911625
102MP0002095_abnormal_skin_pigmentation0.62855836
103MP0001348_abnormal_lacrimal_gland0.62475960
104MP0008874_decreased_physiological_sensi0.62143047
105MP0000609_abnormal_liver_physiology0.61314778
106MP0003279_aneurysm0.60604854
107MP0003795_abnormal_bone_structure0.59412577
108MP0005165_increased_susceptibility_to0.58326076
109MP0008007_abnormal_cellular_replicative0.57314009
110MP0002332_abnormal_exercise_endurance0.57172433
111MP0000477_abnormal_intestine_morphology0.56467208
112MP0009765_abnormal_xenobiotic_induced0.56371018
113MP0005381_digestive/alimentary_phenotyp0.54003624
114MP0002138_abnormal_hepatobiliary_system0.52753757
115MP0001663_abnormal_digestive_system0.50494658
116MP0000350_abnormal_cell_proliferation0.50491188
117MP0008770_decreased_survivor_rate0.49721643
118MP0000249_abnormal_blood_vessel0.49488364
119MP0000367_abnormal_coat/_hair0.49194666
120MP0009115_abnormal_fat_cell0.48510042
121MP0009764_decreased_sensitivity_to0.48083800
122MP0005319_abnormal_enzyme/_coenzyme0.47618164
123MP0001881_abnormal_mammary_gland0.47502637
124MP0001216_abnormal_epidermal_layer0.46175775
125MP0003453_abnormal_keratinocyte_physiol0.45954569
126MP0003045_fibrosis0.45008654
127MP0004185_abnormal_adipocyte_glucose0.44990546
128MP0000627_abnormal_mammary_gland0.43890235
129MP0002970_abnormal_white_adipose0.43309982
130MP0003091_abnormal_cell_migration0.41442411
131MP0000313_abnormal_cell_death0.40510056
132MP0003959_abnormal_lean_body0.40270121
133MP0009763_increased_sensitivity_to0.39680870

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)9.60911223
2Abnormality of T cell number (HP:0011839)9.16089086
3Abnormality of B cell number (HP:0010975)7.63290163
4B lymphocytopenia (HP:0010976)7.63290163
5Severe combined immunodeficiency (HP:0004430)7.45330914
6Panhypogammaglobulinemia (HP:0003139)6.92593280
7Combined immunodeficiency (HP:0005387)6.87290356
8Abnormality of T cells (HP:0002843)5.92965153
9Thyroiditis (HP:0100646)5.88830908
10Hypoplasia of the thymus (HP:0000778)5.83465355
11Eosinophilia (HP:0001880)5.76899216
12Recurrent viral infections (HP:0004429)5.75645415
13Recurrent abscess formation (HP:0002722)5.27480880
14Abnormality of liposaccharide metabolism (HP:0010968)5.25951534
15Abnormality of glycosphingolipid metabolism (HP:0004343)5.25951534
16Abnormality of glycolipid metabolism (HP:0010969)5.25951534
17Abnormality of macrophages (HP:0004311)5.24851261
18Recurrent bacterial skin infections (HP:0005406)5.18122870
19Abnormality of eosinophils (HP:0001879)4.97445392
20Recurrent fungal infections (HP:0002841)4.95930588
21Granulocytopenia (HP:0001913)4.80214381
22IgG deficiency (HP:0004315)4.65386952
23Systemic lupus erythematosus (HP:0002725)4.46650542
24Recurrent gram-negative bacterial infections (HP:0005420)4.40120902
25Stomatitis (HP:0010280)4.30898092
26Increased cerebral lipofuscin (HP:0011813)4.24410136
27Vacuolated lymphocytes (HP:0001922)4.18290506
28Elevated erythrocyte sedimentation rate (HP:0003565)4.14640176
29Leukocytosis (HP:0001974)4.00384665
30Abnormality of the fingertips (HP:0001211)3.95670248
31Dysostosis multiplex (HP:0000943)3.79909095
32IgM deficiency (HP:0002850)3.70225541
33Myositis (HP:0100614)3.62170930
34Recurrent bronchitis (HP:0002837)3.62055682
35Loss of speech (HP:0002371)3.59127971
36Increased neuronal autofluorescent lipopigment (HP:0002074)3.48913063
37Chronic mucocutaneous candidiasis (HP:0002728)3.35778913
38Recurrent cutaneous fungal infections (HP:0011370)3.35778913
39Disinhibition (HP:0000734)3.34554003
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.29997567
41Hypoproteinemia (HP:0003075)3.26887077
42Nasal polyposis (HP:0100582)3.11901583
43Chronic diarrhea (HP:0002028)3.10666061
44Pustule (HP:0200039)3.07621214
45Gingivitis (HP:0000230)3.00461659
46Optic neuritis (HP:0100653)2.99295187
47Retrobulbar optic neuritis (HP:0100654)2.99295187
48Abnormality of T cell physiology (HP:0011840)2.97878160
49Autoimmune hemolytic anemia (HP:0001890)2.93327967
50Mutism (HP:0002300)2.90960451
51Purpura (HP:0000979)2.88004981
52Chronic otitis media (HP:0000389)2.87962725
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.87930857
54Abnormality of polysaccharide metabolism (HP:0011012)2.87930857
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.87930857
56Increased IgM level (HP:0003496)2.84270949
57Orchitis (HP:0100796)2.81432029
58Amyloidosis (HP:0011034)2.80019574
59Glomerulonephritis (HP:0000099)2.76606529
60Joint swelling (HP:0001386)2.76300675
61Mucopolysacchariduria (HP:0008155)2.75775965
62Urinary glycosaminoglycan excretion (HP:0003541)2.75775965
63Meningitis (HP:0001287)2.73692143
64IgA deficiency (HP:0002720)2.73051539
65Hematochezia (HP:0002573)2.59766978
66Urticaria (HP:0001025)2.58343031
67Hemoptysis (HP:0002105)2.57641707
68Pulmonary infiltrates (HP:0002113)2.56449841
69Increased serum ferritin (HP:0003281)2.56441127
70Autoimmune thrombocytopenia (HP:0001973)2.54840764
71Abnormality of the nasal mucosa (HP:0000433)2.54807355
72Lymphoma (HP:0002665)2.54292593
73Lymphopenia (HP:0001888)2.53767774
74Eczematoid dermatitis (HP:0000976)2.53112885
75Aplasia/Hypoplasia of the thymus (HP:0010515)2.46630933
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.46031736
77Petechiae (HP:0000967)2.42816904
78Vasculitis (HP:0002633)2.42594611
79Basal cell carcinoma (HP:0002671)2.39037139
80Increased density of long bones (HP:0006392)2.33938152
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30256043
82Complement deficiency (HP:0004431)2.27678915
83Persistence of primary teeth (HP:0006335)2.26165887
84Abnormality of the vasculature of the conjunctiva (HP:0008054)2.24164007
85Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.24032159
86Encephalitis (HP:0002383)2.21483382
87Colitis (HP:0002583)2.18894856
88Cellulitis (HP:0100658)2.18548750
89Abnormality of iron homeostasis (HP:0011031)2.18427177
90Hepatosplenomegaly (HP:0001433)2.17849907
91Polyneuropathy (HP:0001271)2.17603906
92Neuronal loss in central nervous system (HP:0002529)2.17263662
93Axonal loss (HP:0003447)2.16376114
94Spontaneous hematomas (HP:0007420)2.13295954
95Cheilitis (HP:0100825)2.11018954
96Inflammation of the large intestine (HP:0002037)2.09716956
97Keratoconjunctivitis sicca (HP:0001097)2.09623131
98Erythroderma (HP:0001019)2.09420932
99Abnormality of complement system (HP:0005339)2.08176096
100Interstitial pulmonary disease (HP:0006530)2.06585487
101Episodic fever (HP:0001954)2.05982188
102Gastrointestinal inflammation (HP:0004386)2.04376321
103Recurrent sinusitis (HP:0011108)2.03316630
104Increased IgE level (HP:0003212)2.02865502
105Neurofibrillary tangles (HP:0002185)2.01882415
106Papilloma (HP:0012740)2.01843502
107Verrucae (HP:0200043)2.01843502
108Anorexia (HP:0002039)2.01709354
109Arterial thrombosis (HP:0004420)2.00750195
110Gastrointestinal infarctions (HP:0005244)2.00252865
111Malnutrition (HP:0004395)2.00215435
112Bronchitis (HP:0012387)1.98860232
113Abnormality of the thymus (HP:0000777)1.98019261
114Upper motor neuron abnormality (HP:0002127)1.96873079
115Chest pain (HP:0100749)1.96735008
116Progressive neurologic deterioration (HP:0002344)1.95997069
117Restrictive lung disease (HP:0002091)1.95885923
118Basal ganglia calcification (HP:0002135)1.93020616
119Myocardial infarction (HP:0001658)1.91931392
120Nuclear cataract (HP:0100018)1.91538997
121Ureteral stenosis (HP:0000071)1.89809824
122Keratoconjunctivitis (HP:0001096)1.88568580
123Volvulus (HP:0002580)1.87008231
124Hypergammaglobulinemia (HP:0010702)1.84528421
125Bicuspid aortic valve (HP:0001647)1.84130901
126Pulmonary embolism (HP:0002204)1.84110284
127Bronchiectasis (HP:0002110)1.79544156
128Ureteral obstruction (HP:0006000)1.75217717
129Dislocated radial head (HP:0003083)1.74198795
130Mediastinal lymphadenopathy (HP:0100721)1.73463987
131Abnormality of the prostate (HP:0008775)1.69650384
132Cellular immunodeficiency (HP:0005374)1.68600675
133Recurrent skin infections (HP:0001581)1.68353587
134Recurrent otitis media (HP:0000403)1.62942201
135Epistaxis (HP:0000421)1.62672121
136Abnormal platelet volume (HP:0011876)1.62208702
137Abnormality of the radial head (HP:0003995)1.61065746
138Obstructive lung disease (HP:0006536)1.56890611
139Chronic obstructive pulmonary disease (HP:0006510)1.56890611
140Gingival bleeding (HP:0000225)1.54632346
141Gangrene (HP:0100758)1.49872791
142Abnormality of the pleura (HP:0002103)1.49736575
143Prolonged bleeding time (HP:0003010)1.48475927
144Deep philtrum (HP:0002002)1.48348695
145Periodontitis (HP:0000704)1.46806414
146Emphysema (HP:0002097)1.45097031
147Hepatitis (HP:0012115)1.44871841
148Abnormality of oral frenula (HP:0000190)1.44355242
149Thrombocytosis (HP:0001894)1.44145417
150Cutis marmorata (HP:0000965)1.43948577
151Broad palm (HP:0001169)1.42321266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.33336764
2MAP4K15.46468600
3RIPK43.88832060
4ITK3.38038393
5ZAP703.12366473
6JAK32.95441635
7FGFR42.95114298
8STK102.56628731
9GRK62.54835764
10CDK122.52094392
11ERN12.34087949
12TYK22.28453617
13FGFR32.26197586
14IKBKE2.02439713
15MAP3K31.92626266
16LCK1.91436773
17NLK1.79920379
18FGR1.78276146
19IRAK31.77935930
20MAP3K141.76330023
21JAK11.74980774
22MAP3K111.64188066
23HCK1.64185139
24SYK1.63772881
25GRK71.62372872
26TAOK21.53107706
27CSK1.51653734
28MAP3K71.51042763
29TEC1.47789882
30PDGFRB1.43925553
31EEF2K1.40751087
32TYRO31.40229173
33SIK21.39763434
34MAPK71.36018598
35MATK1.29995122
36MAP3K101.26706583
37PRKCH1.22448691
38MAP3K131.21801019
39MAP3K11.17584896
40RIPK11.17458307
41CDC42BPA1.09525785
42JAK21.09134378
43PKN21.08595673
44MARK21.06384202
45MST41.03197098
46BMPR21.00603249
47BTK1.00379439
48MARK30.97438522
49BRD40.93918422
50* PRKCQ0.92548194
51IKBKB0.92423589
52TBK10.91455042
53CHUK0.87061975
54YES10.84622656
55MOS0.81963517
56SIK30.77981002
57CAMKK10.77027728
58IRAK10.77008576
59HIPK20.76522793
60EPHB10.75216409
61FGFR20.73563271
62EPHA30.73344800
63LRRK20.73249195
64CLK10.71595478
65TNK20.71418726
66TRIB30.70331410
67PDPK10.70171600
68PIM10.70091087
69ALK0.68571161
70DDR20.67593198
71TGFBR20.66289103
72CDK60.64707648
73IRAK20.64549054
74NTRK20.64306460
75RPS6KA40.63687270
76MAPK120.61567491
77FES0.61460270
78CSF1R0.61193936
79CDK40.61191377
80KSR20.60115914
81TAOK10.58142336
82MELK0.55634844
83ACVR1B0.53550247
84NME20.53391237
85CAMK40.51449615
86MAPK40.51177392
87RPS6KC10.51124151
88RPS6KL10.51124151
89INSR0.50956554
90TAOK30.50678892
91CAMK1D0.50348905
92SGK30.50330044
93MAP3K50.49170662
94PDK10.48849745
95KIT0.48374085
96LYN0.47979186
97CSNK1A1L0.47086550
98FYN0.46964905
99MAP2K60.46182401
100FGFR10.45911238
101SMG10.45209168
102PRKD20.42352226
103STK40.42035006
104RPS6KA60.41402412
105TTN0.40734868
106CAMKK20.40495169
107DYRK1B0.38424172
108PIM20.38314728
109IGF1R0.37986290
110PRPF4B0.36240681
111PTK60.36133987
112CDK90.35609891
113BLK0.35074668
114PIK3CG0.34628956
115TESK20.33867979
116EGFR0.32671832
117ABL10.31944750
118MAPK30.31458820
119RET0.31439466
120DMPK0.31356698
121CHEK10.31049676
122ICK0.30818096
123RPS6KA20.30632961
124MAPKAPK20.30164656
125SIK10.27978599
126IRAK40.27060912
127NEK20.26884718
128MAPK110.25538768
129MAPK80.25476083
130WNK10.24723706
131MAP2K30.23370236
132FLT30.19474719
133MAPK90.19099867
134MAP3K80.18249856
135CAMK10.17888129

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053406.18141209
2* T cell receptor signaling pathway_Homo sapiens_hsa046604.42319465
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.34874100
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.34108645
5Other glycan degradation_Homo sapiens_hsa005112.88401401
6Allograft rejection_Homo sapiens_hsa053302.69332681
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.52156146
8Measles_Homo sapiens_hsa051622.51634552
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.36369007
10Autoimmune thyroid disease_Homo sapiens_hsa053202.35530984
11Lysosome_Homo sapiens_hsa041422.11410070
12Osteoclast differentiation_Homo sapiens_hsa043801.91594193
13* Hematopoietic cell lineage_Homo sapiens_hsa046401.75319517
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.74174162
15Leishmaniasis_Homo sapiens_hsa051401.64821923
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64768939
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.62157134
18Acute myeloid leukemia_Homo sapiens_hsa052211.61285373
19Viral myocarditis_Homo sapiens_hsa054161.58913491
20B cell receptor signaling pathway_Homo sapiens_hsa046621.55753727
21Phagosome_Homo sapiens_hsa041451.49075212
22Non-homologous end-joining_Homo sapiens_hsa034501.43799595
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43366018
24Chemokine signaling pathway_Homo sapiens_hsa040621.42446235
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41495730
26Asthma_Homo sapiens_hsa053101.40408847
27Graft-versus-host disease_Homo sapiens_hsa053321.37846571
28Herpes simplex infection_Homo sapiens_hsa051681.36178123
29* Antigen processing and presentation_Homo sapiens_hsa046121.36165362
30Chronic myeloid leukemia_Homo sapiens_hsa052201.32296058
31Hepatitis B_Homo sapiens_hsa051611.28824705
32Toxoplasmosis_Homo sapiens_hsa051451.22804836
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22797293
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.21820643
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21475273
36HTLV-I infection_Homo sapiens_hsa051661.20804304
37* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19526690
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12855588
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09603816
40Colorectal cancer_Homo sapiens_hsa052101.08363172
41Type I diabetes mellitus_Homo sapiens_hsa049401.05986948
42Thyroid cancer_Homo sapiens_hsa052161.03777370
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03395806
44Pancreatic cancer_Homo sapiens_hsa052121.02754071
45Prolactin signaling pathway_Homo sapiens_hsa049171.02592018
46TNF signaling pathway_Homo sapiens_hsa046681.01930901
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97308914
48Influenza A_Homo sapiens_hsa051640.97145361
49Platelet activation_Homo sapiens_hsa046110.87688686
50Non-small cell lung cancer_Homo sapiens_hsa052230.87577225
51Complement and coagulation cascades_Homo sapiens_hsa046100.87449023
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85491886
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83819576
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82967428
55FoxO signaling pathway_Homo sapiens_hsa040680.82760647
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82192061
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81971576
58Viral carcinogenesis_Homo sapiens_hsa052030.80795179
59Apoptosis_Homo sapiens_hsa042100.80604811
60Prion diseases_Homo sapiens_hsa050200.80357602
61Shigellosis_Homo sapiens_hsa051310.79719812
62Endometrial cancer_Homo sapiens_hsa052130.74869567
63VEGF signaling pathway_Homo sapiens_hsa043700.74831686
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.74214527
65Amoebiasis_Homo sapiens_hsa051460.72467099
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71446575
67Epstein-Barr virus infection_Homo sapiens_hsa051690.70554248
68Dorso-ventral axis formation_Homo sapiens_hsa043200.69591886
69mTOR signaling pathway_Homo sapiens_hsa041500.69047453
70Hepatitis C_Homo sapiens_hsa051600.68321426
71Prostate cancer_Homo sapiens_hsa052150.67621083
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67550633
73Renal cell carcinoma_Homo sapiens_hsa052110.66991462
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66897986
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65466600
76MAPK signaling pathway_Homo sapiens_hsa040100.63138593
77Staphylococcus aureus infection_Homo sapiens_hsa051500.61823538
78Collecting duct acid secretion_Homo sapiens_hsa049660.61154415
79Lysine degradation_Homo sapiens_hsa003100.61113212
80Choline metabolism in cancer_Homo sapiens_hsa052310.59532893
81Inositol phosphate metabolism_Homo sapiens_hsa005620.58322565
82Small cell lung cancer_Homo sapiens_hsa052220.56468970
83Tuberculosis_Homo sapiens_hsa051520.56331621
84mRNA surveillance pathway_Homo sapiens_hsa030150.53225358
85Notch signaling pathway_Homo sapiens_hsa043300.53189475
86Rap1 signaling pathway_Homo sapiens_hsa040150.51810247
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51491681
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50373279
89Circadian rhythm_Homo sapiens_hsa047100.49225597
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47027369
91Legionellosis_Homo sapiens_hsa051340.46711019
92MicroRNAs in cancer_Homo sapiens_hsa052060.46655496
93Malaria_Homo sapiens_hsa051440.46447540
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46301408
95Pathways in cancer_Homo sapiens_hsa052000.46056584
96Insulin resistance_Homo sapiens_hsa049310.45907703
97p53 signaling pathway_Homo sapiens_hsa041150.45772607
98ErbB signaling pathway_Homo sapiens_hsa040120.43663216
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.42567690
100Endocytosis_Homo sapiens_hsa041440.42259752
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42204478
102Adherens junction_Homo sapiens_hsa045200.40730470
103Spliceosome_Homo sapiens_hsa030400.40449259
104GnRH signaling pathway_Homo sapiens_hsa049120.38589546
105Bladder cancer_Homo sapiens_hsa052190.37841385
106Type II diabetes mellitus_Homo sapiens_hsa049300.37527191
107Rheumatoid arthritis_Homo sapiens_hsa053230.37126951
108RNA degradation_Homo sapiens_hsa030180.36692381
109HIF-1 signaling pathway_Homo sapiens_hsa040660.36679445
110Pertussis_Homo sapiens_hsa051330.35150309
111Salmonella infection_Homo sapiens_hsa051320.34851809
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33285084
113Long-term potentiation_Homo sapiens_hsa047200.32980690
114Proteoglycans in cancer_Homo sapiens_hsa052050.32052564
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.31853841
116Sphingolipid metabolism_Homo sapiens_hsa006000.31699798
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.31185111
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29795970
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28504575
120Ras signaling pathway_Homo sapiens_hsa040140.27974427
121African trypanosomiasis_Homo sapiens_hsa051430.25712331
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24295465
123Galactose metabolism_Homo sapiens_hsa000520.20820385

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