CD40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)5.76846846
2positive regulation of interferon-alpha production (GO:0032727)5.33911351
3regulation of T-helper 1 cell differentiation (GO:0045625)5.26413978
4neutrophil activation involved in immune response (GO:0002283)5.11207066
5regulation of vitamin D biosynthetic process (GO:0060556)5.06401570
6regulation of interferon-alpha production (GO:0032647)5.02700938
7cellular response to type I interferon (GO:0071357)4.95552208
8type I interferon signaling pathway (GO:0060337)4.95552208
9T-helper 1 type immune response (GO:0042088)4.94845938
10response to type I interferon (GO:0034340)4.89884837
11positive regulation of type 2 immune response (GO:0002830)4.87998367
12positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.72477961
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.70403221
14response to peptidoglycan (GO:0032494)4.67874710
15regulation of dendritic cell antigen processing and presentation (GO:0002604)4.67650758
16negative regulation of interleukin-12 production (GO:0032695)4.60700648
17natural killer cell mediated cytotoxicity (GO:0042267)4.48073164
18natural killer cell mediated immunity (GO:0002228)4.48073164
19regulation of cytokine secretion involved in immune response (GO:0002739)4.45785825
20positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.45563706
21positive regulation of natural killer cell differentiation (GO:0032825)4.41646173
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.39294240
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.39294240
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.39294240
25modulation by symbiont of host immune response (GO:0052553)4.39294240
26positive regulation by symbiont of host defense response (GO:0052509)4.39294240
27modulation by symbiont of host defense response (GO:0052031)4.39294240
28antigen processing and presentation of endogenous antigen (GO:0019883)4.39160264
29regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.27540508
30positive regulation of T-helper cell differentiation (GO:0045624)4.25715363
31NIK/NF-kappaB signaling (GO:0038061)4.19211886
32negative regulation of viral genome replication (GO:0045071)4.16743268
33regulation of RIG-I signaling pathway (GO:0039535)4.16734358
34granulocyte activation (GO:0036230)4.14287710
35neutrophil activation (GO:0042119)4.13118455
36* positive regulation of interleukin-12 production (GO:0032735)4.06253070
37regulation of vitamin metabolic process (GO:0030656)4.05951545
38immunoglobulin mediated immune response (GO:0016064)4.02936214
39positive regulation of antigen processing and presentation (GO:0002579)4.02875629
40cellular response to interferon-alpha (GO:0035457)4.01789571
41cellular response to interferon-beta (GO:0035458)3.99524329
42positive regulation of interleukin-17 production (GO:0032740)3.93719589
43response to interferon-alpha (GO:0035455)3.91818451
44lipopolysaccharide-mediated signaling pathway (GO:0031663)3.91573789
45response to muramyl dipeptide (GO:0032495)3.89971718
46cellular response to virus (GO:0098586)3.88987925
47myeloid dendritic cell differentiation (GO:0043011)3.87272700
48defense response to protozoan (GO:0042832)3.86756596
49cellular response to exogenous dsRNA (GO:0071360)3.86618736
50interferon-gamma-mediated signaling pathway (GO:0060333)3.84684862
51negative regulation of interleukin-17 production (GO:0032700)3.81705090
52positive regulation of interferon-beta production (GO:0032728)3.80923661
53germinal center formation (GO:0002467)3.78076772
54positive regulation of alpha-beta T cell proliferation (GO:0046641)3.77931942
55positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.77914759
56regulation of interferon-gamma biosynthetic process (GO:0045072)3.76826494
57negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.76263520
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.74470846
59regulation of T-helper cell differentiation (GO:0045622)3.72641240
60regulation of alpha-beta T cell proliferation (GO:0046640)3.68237709
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.64950345
62regulation of podosome assembly (GO:0071801)3.64144142
63regulation of memory T cell differentiation (GO:0043380)3.62255687
64hydrogen peroxide biosynthetic process (GO:0050665)3.59246645
65cellular response to zinc ion (GO:0071294)3.57205977
66positive regulation of T cell cytokine production (GO:0002726)3.55758439
67regulation of interleukin-12 biosynthetic process (GO:0045075)3.54905230
68regulation of T-helper 2 cell differentiation (GO:0045628)3.54044556
69regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.53354828
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52291326
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.52291326
72CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.51628763
73dendritic cell differentiation (GO:0097028)3.51016906
74positive regulation of heat generation (GO:0031652)3.50111967
75regulation of antigen processing and presentation (GO:0002577)3.46204967
76myeloid dendritic cell activation (GO:0001773)3.46173546
77regulation of interferon-beta biosynthetic process (GO:0045357)3.46108294
78regulation of fever generation (GO:0031620)3.45306339
79respiratory burst (GO:0045730)3.41756538
80monocyte chemotaxis (GO:0002548)3.39738986
81positive regulation of monocyte chemotaxis (GO:0090026)3.39572751
82regulation of interleukin-17 production (GO:0032660)3.39305370
83macrophage activation involved in immune response (GO:0002281)3.39028590
84response to interferon-beta (GO:0035456)3.38549036
85positive regulation of response to biotic stimulus (GO:0002833)3.36937604
86negative regulation of myeloid cell apoptotic process (GO:0033033)3.36820857
87regulation of T-helper 1 type immune response (GO:0002825)3.36711007
88superoxide anion generation (GO:0042554)3.36252783
89response to interferon-gamma (GO:0034341)3.34908710
90positive regulation of gamma-delta T cell activation (GO:0046645)3.34463488
91eosinophil chemotaxis (GO:0048245)3.32975312
92regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.31381615
93regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.29401822
94leukocyte mediated cytotoxicity (GO:0001909)3.29100295
95B cell mediated immunity (GO:0019724)3.28912331
96regulation of type I interferon-mediated signaling pathway (GO:0060338)3.28828951
97cellular response to interferon-gamma (GO:0071346)3.26889420
98branching involved in labyrinthine layer morphogenesis (GO:0060670)3.26223440
99positive regulation of defense response to virus by host (GO:0002230)3.25681530
100negative regulation of cytokine production involved in immune response (GO:0002719)3.23566649
101response to protozoan (GO:0001562)3.22257924
102response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.21121483
103response to host immune response (GO:0052572)3.21121483
104regulation of inflammatory response to antigenic stimulus (GO:0002861)3.20675752
105positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.17236419
106positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.16575083
107reactive oxygen species biosynthetic process (GO:1903409)3.16015205
108positive regulation of NF-kappaB import into nucleus (GO:0042346)3.15744512
109positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.15687284
110positive regulation of T-helper 1 type immune response (GO:0002827)3.15067877
111T cell migration (GO:0072678)3.14765188
112positive regulation of chemokine biosynthetic process (GO:0045080)3.14446410
113* regulation of interleukin-12 production (GO:0032655)3.13764411
114regulation of chemokine biosynthetic process (GO:0045073)3.13608989
115regulation of mononuclear cell migration (GO:0071675)3.12201967
116lymphocyte chemotaxis (GO:0048247)3.11262958
117activation of MAPKKK activity (GO:0000185)3.11074237
118positive regulation of interleukin-10 production (GO:0032733)3.10667207
119positive regulation of cellular amide metabolic process (GO:0034250)3.08565887
120regulation of defense response to virus by host (GO:0050691)3.08543952
121regulation of chronic inflammatory response (GO:0002676)3.07364748
122positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.03850055
123detection of other organism (GO:0098543)3.00301871
124negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.00220983
125regulation of type 2 immune response (GO:0002828)2.99240909
126detection of bacterium (GO:0016045)2.98143977
127negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96608472
128negative regulation of cell killing (GO:0031342)2.96608472
129negative regulation of nitric oxide biosynthetic process (GO:0045019)2.95985166
130regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.87436577
131regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.85775065
132positive regulation of cytokine biosynthetic process (GO:0042108)2.85197650
133mature B cell differentiation involved in immune response (GO:0002313)2.84812858
134regulation of interleukin-8 biosynthetic process (GO:0045414)2.84796747
135regulation of interleukin-2 biosynthetic process (GO:0045076)2.84477679
136regulation of T cell tolerance induction (GO:0002664)2.84259431
137* cellular response to lipopolysaccharide (GO:0071222)2.83628715
138modulation of growth of symbiont involved in interaction with host (GO:0044144)2.82114685
139regulation of growth of symbiont in host (GO:0044126)2.82114685
140negative regulation of growth of symbiont in host (GO:0044130)2.82114685
141negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.82114685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.88323597
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.72143630
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.29221953
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.60073479
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.14694368
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.68677486
7* IRF8_27001747_Chip-Seq_BMDM_Mouse4.32433606
8* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.63598023
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56799284
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.27551354
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.11988060
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.05771094
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.95931350
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.95768389
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.87706242
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69034860
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.44054922
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30707822
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.13599194
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.08207780
21MYC_22102868_ChIP-Seq_BL_Human1.92180747
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.81880296
23SPI1_23547873_ChIP-Seq_NB4_Human1.73923080
24VDR_24787735_ChIP-Seq_THP-1_Human1.69701299
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62664580
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60754390
27GATA1_22025678_ChIP-Seq_K562_Human1.58384011
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57392649
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57200744
30MYB_26560356_Chip-Seq_TH2_Human1.55546508
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54091284
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53201393
33PU_27001747_Chip-Seq_BMDM_Mouse1.48692214
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48091804
35CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47833101
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46335985
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43871718
38RUNX_20019798_ChIP-Seq_JUKART_Human1.41592117
39MAF_26560356_Chip-Seq_TH1_Human1.31947156
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31033737
41GATA3_26560356_Chip-Seq_TH2_Human1.30467591
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30161525
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29937868
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.27578623
45LXR_22292898_ChIP-Seq_THP-1_Human1.25927084
46MYB_26560356_Chip-Seq_TH1_Human1.25765195
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20411898
48VDR_24763502_ChIP-Seq_THP-1_Human1.19971590
49CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19562143
50PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18376402
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16675765
52SPI1_23127762_ChIP-Seq_K562_Human1.15210002
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.13916779
54* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10853861
55TCF7_22412390_ChIP-Seq_EML_Mouse1.08497149
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.08425248
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.06143289
58GATA3_27048872_Chip-Seq_THYMUS_Human1.05769524
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04016052
60TFEB_21752829_ChIP-Seq_HELA_Human1.03454032
61STAT1_20625510_ChIP-Seq_HELA_Human1.02541865
62SCL_19346495_ChIP-Seq_HPC-7_Human0.99466476
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98687855
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98421999
65CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97443889
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96688706
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96286991
68EGR1_19032775_ChIP-ChIP_M12_Human0.94352967
69KDM2B_26808549_Chip-Seq_DND41_Human0.93054712
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92434683
71GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92285755
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91856383
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91757098
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90168402
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89810109
76NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89330687
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89330687
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88488981
79* BCL6_27268052_Chip-Seq_Bcells_Human0.88456016
80BCOR_27268052_Chip-Seq_Bcells_Human0.86750220
81GATA1_19941826_ChIP-Seq_K562_Human0.86691292
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84141812
83IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83976325
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83453540
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83369408
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82864419
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82586852
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82513647
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82402014
90SOX2_20726797_ChIP-Seq_SW620_Human0.82078521
91GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82028132
92SMRT_27268052_Chip-Seq_Bcells_Human0.81607306
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81050517
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80861173
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78776880
96* ELF1_20517297_ChIP-Seq_JURKAT_Human0.78289941
97ESR2_21235772_ChIP-Seq_MCF-7_Human0.78145599
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.77941605
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76962292
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.76496591
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.74783258
102NCOR1_26117541_ChIP-Seq_K562_Human0.74734073
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.73811828
104TRIM28_21343339_ChIP-Seq_HEK293_Human0.73002704
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.72467922
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.72467922
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72240192
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.66691649
109MAF_26560356_Chip-Seq_TH2_Human0.65443619
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64244688
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.63764734
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62951947
113* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.60189965
114CJUN_26792858_Chip-Seq_BT549_Human0.58489837
115KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.56825781
116PU1_27457419_Chip-Seq_LIVER_Mouse0.56568831
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.56474783
118UTX_26944678_Chip-Seq_JUKART_Human0.54429630
119VDR_21846776_ChIP-Seq_THP-1_Human0.53617215
120PU.1_20513432_ChIP-Seq_Bcells_Mouse0.53270078
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.52174395
122STAT3_18555785_Chip-Seq_ESCs_Mouse0.51370258
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.51323878
124NMYC_18555785_Chip-Seq_ESCs_Mouse0.51116243
125IGF1R_20145208_ChIP-Seq_DFB_Human0.50481038
126VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.47916392
127ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.47910463
128CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.46984924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.42612048
2MP0009785_altered_susceptibility_to4.54186272
3* MP0002148_abnormal_hypersensitivity_rea4.14086212
4MP0000685_abnormal_immune_system3.86039012
5MP0003436_decreased_susceptibility_to3.56095614
6MP0001790_abnormal_immune_system3.55226250
7MP0005387_immune_system_phenotype3.55226250
8MP0005000_abnormal_immune_tolerance3.42780756
9MP0006082_CNS_inflammation3.28366617
10MP0004510_myositis3.22667619
11MP0005025_abnormal_response_to3.19285830
12MP0002419_abnormal_innate_immunity2.97687236
13MP0003724_increased_susceptibility_to2.87757794
14* MP0005671_abnormal_response_to2.84652823
15MP0002452_abnormal_antigen_presenting2.81715813
16MP0003303_peritoneal_inflammation2.79698756
17* MP0001800_abnormal_humoral_immune2.78391732
18* MP0002723_abnormal_immune_serum2.69990387
19MP0003300_gastrointestinal_ulcer2.51186085
20MP0002139_abnormal_hepatobiliary_system2.42555717
21* MP0001819_abnormal_immune_cell2.33785600
22MP0002420_abnormal_adaptive_immunity2.29442605
23MP0005451_abnormal_body_composition2.12934295
24MP0009764_decreased_sensitivity_to2.11720083
25MP0002163_abnormal_gland_morphology2.08710570
26MP0001853_heart_inflammation2.05871834
27MP0005310_abnormal_salivary_gland2.05000905
28MP0001348_abnormal_lacrimal_gland1.98610794
29MP0002006_tumorigenesis1.97284305
30MP0004947_skin_inflammation1.95670874
31MP0001533_abnormal_skeleton_physiology1.85671125
32* MP0001845_abnormal_inflammatory_respons1.81126626
33MP0002405_respiratory_system_inflammati1.80008802
34MP0002138_abnormal_hepatobiliary_system1.79909893
35MP0010155_abnormal_intestine_physiology1.76853857
36MP0003448_altered_tumor_morphology1.76625364
37MP0008469_abnormal_protein_level1.69376120
38* MP0000716_abnormal_immune_system1.69006907
39MP0002254_reproductive_system_inflammat1.63667619
40MP0001346_abnormal_lacrimal_gland1.63341457
41MP0002166_altered_tumor_susceptibility1.61557628
42MP0003806_abnormal_nucleotide_metabolis1.61349432
43MP0002398_abnormal_bone_marrow1.60377753
44MP0008004_abnormal_stomach_pH1.58062484
45MP0002277_abnormal_respiratory_mucosa1.50723260
46MP0005464_abnormal_platelet_physiology1.50403882
47MP0005058_abnormal_lysosome_morphology1.49243820
48MP0009333_abnormal_splenocyte_physiolog1.44430434
49MP0004782_abnormal_surfactant_physiolog1.41467775
50MP0000569_abnormal_digit_pigmentation1.39309126
51MP0006054_spinal_hemorrhage1.36658329
52MP0009278_abnormal_bone_marrow1.29215896
53MP0001545_abnormal_hematopoietic_system1.29197142
54MP0005397_hematopoietic_system_phenotyp1.29197142
55* MP0002429_abnormal_blood_cell1.27997610
56MP0003075_altered_response_to1.25283183
57MP0002998_abnormal_bone_remodeling1.24130607
58MP0000858_altered_metastatic_potential1.19601199
59MP0005167_abnormal_blood-brain_barrier1.18282084
60MP0003172_abnormal_lysosome_physiology1.14353847
61MP0000343_altered_response_to1.13227086
62* MP0000689_abnormal_spleen_morphology1.09299942
63MP0002722_abnormal_immune_system1.08235676
64MP0005379_endocrine/exocrine_gland_phen1.08051565
65MP0009763_increased_sensitivity_to1.00481778
66MP0003763_abnormal_thymus_physiology1.00156640
67MP0003186_abnormal_redox_activity0.98881904
68MP0003091_abnormal_cell_migration0.97924146
69MP0010307_abnormal_tumor_latency0.97085896
70MP0005165_increased_susceptibility_to0.92849106
71MP0005166_decreased_susceptibility_to0.92522564
72MP0005164_abnormal_response_to0.91876220
73MP0005076_abnormal_cell_differentiation0.87466853
74MP0001663_abnormal_digestive_system0.87317086
75MP0003191_abnormal_cellular_cholesterol0.87169007
76MP0000604_amyloidosis0.86030286
77MP0003656_abnormal_erythrocyte_physiolo0.85076960
78MP0005390_skeleton_phenotype0.84613544
79MP0008874_decreased_physiological_sensi0.82772483
80MP0003453_abnormal_keratinocyte_physiol0.76485305
81MP0004858_abnormal_nervous_system0.76013985
82MP0009840_abnormal_foam_cell0.75704020
83MP0001542_abnormal_bone_strength0.73340642
84MP0002876_abnormal_thyroid_physiology0.71346150
85MP0005647_abnormal_sex_gland0.70234668
86MP0000249_abnormal_blood_vessel0.69705506
87MP0002933_joint_inflammation0.67917070
88MP0010386_abnormal_urinary_bladder0.67670579
89MP0000371_diluted_coat_color0.65888782
90MP0001881_abnormal_mammary_gland0.61594787
91MP0004883_abnormal_blood_vessel0.61590479
92MP0002332_abnormal_exercise_endurance0.60795921
93MP0002693_abnormal_pancreas_physiology0.60319214
94MP0009765_abnormal_xenobiotic_induced0.59384696
95MP0003828_pulmonary_edema0.59087057
96MP0005535_abnormal_body_temperature0.58671152
97MP0000609_abnormal_liver_physiology0.58571751
98MP0005023_abnormal_wound_healing0.58553794
99MP0008260_abnormal_autophagy0.57980552
100MP0001873_stomach_inflammation0.57345310
101MP0000465_gastrointestinal_hemorrhage0.57117622
102MP0000920_abnormal_myelination0.56964533
103MP0005174_abnormal_tail_pigmentation0.56801375
104MP0000490_abnormal_crypts_of0.55953202
105MP0000015_abnormal_ear_pigmentation0.55594280
106MP0003566_abnormal_cell_adhesion0.54814558
107MP0003183_abnormal_peptide_metabolism0.54588022
108MP0000627_abnormal_mammary_gland0.54260823
109MP0000703_abnormal_thymus_morphology0.53808769
110MP0005266_abnormal_metabolism0.53720954
111MP0000767_abnormal_smooth_muscle0.53317801
112* MP0002136_abnormal_kidney_physiology0.52926018
113MP0002877_abnormal_melanocyte_morpholog0.52713872
114MP0003795_abnormal_bone_structure0.52594543
115MP0003690_abnormal_glial_cell0.51981669
116MP0005319_abnormal_enzyme/_coenzyme0.49392420
117MP0005381_digestive/alimentary_phenotyp0.48707512
118MP0001851_eye_inflammation0.48434036
119MP0004808_abnormal_hematopoietic_stem0.46369900
120MP0003646_muscle_fatigue0.44482964
121MP0005171_absent_coat_pigmentation0.44080531
122MP0003045_fibrosis0.43706241
123MP0001879_abnormal_lymphatic_vessel0.43310456
124MP0003195_calcinosis0.42550095

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.01142089
2Recurrent bacterial skin infections (HP:0005406)6.76608251
3Eczematoid dermatitis (HP:0000976)6.60260071
4Autoimmune thrombocytopenia (HP:0001973)5.97574720
5Recurrent gram-negative bacterial infections (HP:0005420)5.55215339
6Mediastinal lymphadenopathy (HP:0100721)5.42598954
7Elevated erythrocyte sedimentation rate (HP:0003565)5.06184635
8Abnormality of macrophages (HP:0004311)4.84243453
9Vasculitis (HP:0002633)4.75204043
10Retrobulbar optic neuritis (HP:0100654)4.37210949
11Optic neuritis (HP:0100653)4.37210949
12Gastrointestinal infarctions (HP:0005244)4.31448362
13Recurrent skin infections (HP:0001581)4.21864727
14Orchitis (HP:0100796)4.16571278
15Basal ganglia calcification (HP:0002135)4.08571413
16Myositis (HP:0100614)4.05764797
17Stomatitis (HP:0010280)4.04613718
18Recurrent fungal infections (HP:0002841)4.02466608
19Gingivitis (HP:0000230)4.00099302
20Recurrent viral infections (HP:0004429)3.81057796
21Loss of speech (HP:0002371)3.72326235
22Dysostosis multiplex (HP:0000943)3.59531056
23* Increased IgM level (HP:0003496)3.58132722
24Chronic otitis media (HP:0000389)3.52579585
25Disinhibition (HP:0000734)3.49352271
26Tetraparesis (HP:0002273)3.47076210
27Systemic lupus erythematosus (HP:0002725)3.44846730
28Pulmonary infiltrates (HP:0002113)3.38952096
29Thick nail (HP:0001805)3.36658089
30Obstructive lung disease (HP:0006536)3.34296891
31Chronic obstructive pulmonary disease (HP:0006510)3.34296891
32Periodontitis (HP:0000704)3.33518037
33Porencephaly (HP:0002132)3.18449493
34Chronic mucocutaneous candidiasis (HP:0002728)3.16467775
35Recurrent cutaneous fungal infections (HP:0011370)3.16467775
36Interstitial pulmonary disease (HP:0006530)3.16143563
37Recurrent pneumonia (HP:0006532)3.15407758
38Autoimmune hemolytic anemia (HP:0001890)3.08392985
39Cellulitis (HP:0100658)2.99124423
40Mutism (HP:0002300)2.95724838
41Pustule (HP:0200039)2.94709991
42* Hypergammaglobulinemia (HP:0010702)2.94637314
43Prostate neoplasm (HP:0100787)2.92126165
44Nuclear cataract (HP:0100018)2.89333695
45Urticaria (HP:0001025)2.84365038
46Hemoptysis (HP:0002105)2.83126966
47Premature loss of primary teeth (HP:0006323)2.81901369
48Recurrent sinusitis (HP:0011108)2.80481013
49Recurrent lower respiratory tract infections (HP:0002783)2.80046736
50Meningitis (HP:0001287)2.80034705
51Vacuolated lymphocytes (HP:0001922)2.77799797
52Leukocytosis (HP:0001974)2.71746382
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.70469893
54Eosinophilia (HP:0001880)2.69731425
55Arterial thrombosis (HP:0004420)2.69102239
56Abnormality of T cell number (HP:0011839)2.65211406
57Restrictive lung disease (HP:0002091)2.62245162
58Encephalitis (HP:0002383)2.61236866
59Recurrent bronchitis (HP:0002837)2.59535747
60Osteomyelitis (HP:0002754)2.59181446
61Agammaglobulinemia (HP:0004432)2.59152554
62Parakeratosis (HP:0001036)2.58263618
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55733867
64Abnormality of polysaccharide metabolism (HP:0011012)2.55733867
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55733867
66Increased serum ferritin (HP:0003281)2.53551818
67Gingival bleeding (HP:0000225)2.52713094
68Increased IgE level (HP:0003212)2.51414694
69Hematochezia (HP:0002573)2.44532528
70Gastrointestinal stroma tumor (HP:0100723)2.44345028
71Chronic sinusitis (HP:0011109)2.44337604
72Keratoconjunctivitis (HP:0001096)2.43016778
73Mucopolysacchariduria (HP:0008155)2.42914721
74Urinary glycosaminoglycan excretion (HP:0003541)2.42914721
75Keratoconjunctivitis sicca (HP:0001097)2.42903171
76Progressive neurologic deterioration (HP:0002344)2.39263739
77Joint swelling (HP:0001386)2.36220719
78* IgA deficiency (HP:0002720)2.35334383
79Vertebral compression fractures (HP:0002953)2.35081707
80Nasal polyposis (HP:0100582)2.34455129
81B lymphocytopenia (HP:0010976)2.32830033
82Abnormality of B cell number (HP:0010975)2.31428265
83Cleft eyelid (HP:0000625)2.31241834
84Apathy (HP:0000741)2.30264581
85Anorexia (HP:0002039)2.30169282
86Abnormality of cells of the lymphoid lineage (HP:0012140)2.29575684
87Arthralgia (HP:0002829)2.29011491
88Nausea (HP:0002018)2.28540697
89Polyneuropathy (HP:0001271)2.28305754
90Osteolytic defects of the phalanges of the hand (HP:0009771)2.28210581
91Osteolytic defects of the hand bones (HP:0009699)2.28210581
92Axonal loss (HP:0003447)2.26413560
93Granulocytopenia (HP:0001913)2.25727800
94Hepatosplenomegaly (HP:0001433)2.24310807
95Abnormality of T cell physiology (HP:0011840)2.20980260
96Colitis (HP:0002583)2.20773193
97Gangrene (HP:0100758)2.19871527
98Poor head control (HP:0002421)2.19702577
99Diminished motivation (HP:0000745)2.19015254
100Chest pain (HP:0100749)2.18436669
101Myocardial infarction (HP:0001658)2.18025896
102Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.17570238
103Neurofibrillary tangles (HP:0002185)2.17188130
104Abnormality of the pericardium (HP:0001697)2.16290143
105Petechiae (HP:0000967)2.15881641
106Emphysema (HP:0002097)2.14152215
107IgM deficiency (HP:0002850)2.13136990
108Abnormality of liposaccharide metabolism (HP:0010968)2.12968006
109Abnormality of glycosphingolipid metabolism (HP:0004343)2.12968006
110Abnormality of glycolipid metabolism (HP:0010969)2.12968006
111Increased neuronal autofluorescent lipopigment (HP:0002074)2.12404002
112Abnormality of eosinophils (HP:0001879)2.11542359
113Increased cerebral lipofuscin (HP:0011813)2.10164591
114Bone pain (HP:0002653)2.10143104
115Complement deficiency (HP:0004431)2.09477974
116Amaurosis fugax (HP:0100576)2.09025583
117T lymphocytopenia (HP:0005403)2.08451139
118Skin ulcer (HP:0200042)2.08028086
119Abnormality of the nasal mucosa (HP:0000433)2.06359832
120Abnormality of T cells (HP:0002843)2.04359131
121Chronic diarrhea (HP:0002028)2.04132602
122Lymphopenia (HP:0001888)2.03922806
123Memory impairment (HP:0002354)2.02527277
124Hypertensive crisis (HP:0100735)2.02305534
125Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00431804
126Prolonged neonatal jaundice (HP:0006579)1.96448052
127Progressive visual loss (HP:0000529)1.96337186
128Purpura (HP:0000979)1.95140933
129Sepsis (HP:0100806)1.92088862
130Abnormality of the pleura (HP:0002103)1.88635938
131Glomerulonephritis (HP:0000099)1.86532309
132Inflammation of the large intestine (HP:0002037)1.84654381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.01838322
2TBK14.14481762
3PBK4.00141060
4RIPK43.74552062
5TYK23.61043486
6IRAK43.40199009
7IKBKE3.25835274
8JAK33.20162605
9IKBKB3.13838060
10BLK3.08555258
11IRAK32.82089487
12MAP3K132.76472496
13TAOK22.53843534
14PRPF4B2.51056951
15DDR22.46225490
16PIM22.40625870
17JAK12.25547452
18CHUK2.17717406
19BMPR21.97928800
20TXK1.81180543
21MST41.77122055
22MAP4K11.61837408
23KIT1.57196549
24SYK1.50441693
25CDC42BPA1.45220742
26MAP3K31.42519226
27SIK31.39053038
28TAOK11.30905744
29BCR1.25503828
30NEK91.24783252
31EIF2AK21.22534658
32TGFBR21.16612592
33CSK1.13562767
34ARAF1.13055403
35PIM11.09668612
36ZAP701.08831991
37MARK31.06608758
38RPS6KA41.03987147
39STK41.03364981
40MAP2K31.03045938
41IRAK11.01301795
42JAK21.00184023
43BMX0.99752901
44HCK0.98266425
45ABL20.97401972
46LYN0.95599158
47FGFR30.94841580
48ERN10.92230884
49FGFR40.91926662
50BTK0.91512483
51EPHB10.87887001
52LCK0.87746191
53ERBB30.84660207
54TAOK30.84458802
55MAP3K50.82894135
56IRAK20.82295199
57EPHA30.80966789
58TLK10.79883627
59MATK0.78093865
60CSF1R0.76019764
61PKN10.75320934
62TESK20.70217933
63NME20.69829662
64PRKCD0.65571357
65PRKCQ0.65428687
66YES10.64441487
67FGR0.63227673
68CLK10.62569812
69SMG10.58266642
70TRPM70.57862569
71ABL10.57516409
72SIK20.56403835
73INSRR0.56071160
74HIPK20.56051307
75TESK10.54553964
76BMPR1B0.54245990
77TEC0.51251382
78MAPK40.48599174
79STK30.48547154
80MAPKAPK20.48291599
81NUAK10.48018546
82EGFR0.47460988
83ADRBK20.42419767
84EIF2AK30.42017734
85KDR0.41821672
86PLK20.38420478
87TYRO30.38126806
88MST1R0.36938056
89DAPK30.36805922
90MAPK70.36259956
91NLK0.36233679
92CDK40.36160259
93MAP2K60.35064153
94PTK60.33199252
95MAP3K80.32272527
96ERBB40.30891249
97CDK60.30660499
98PDK10.29034234
99GRK70.28935847
100MAPK110.28231613
101FES0.28107630
102RPS6KA10.26767213
103MOS0.26500671
104RPS6KA50.26045156
105PLK40.23737626
106PRKCE0.23601808
107CCNB10.23458674
108LATS20.22466869
109MAP3K90.22311219
110MAP3K110.21921643
111ZAK0.21871235
112ACVR1B0.21437529
113RIPK10.18330602
114STK100.17981175
115PDGFRA0.17878114
116DYRK1B0.17317254
117SGK10.17277564
118INSR0.15722171
119FYN0.15329105
120IGF1R0.14948491
121BRAF0.14778151
122MAP3K10.14575348
123PAK40.14517486
124RPS6KA60.14065039
125SRC0.11410979
126STK240.11393879
127PIK3CG0.10944124
128PTK2B0.10879241
129LRRK20.10724640
130CDK120.10653284
131DAPK20.10377922

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.99746817
2* Allograft rejection_Homo sapiens_hsa053303.58047064
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.33015888
4Leishmaniasis_Homo sapiens_hsa051403.19962491
5* Toll-like receptor signaling pathway_Homo sapiens_hsa046203.06743018
6Type I diabetes mellitus_Homo sapiens_hsa049403.05183580
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.89997563
8* NF-kappa B signaling pathway_Homo sapiens_hsa040642.82787987
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.64636087
10Measles_Homo sapiens_hsa051622.52318763
11* Intestinal immune network for IgA production_Homo sapiens_hsa046722.40963302
12Legionellosis_Homo sapiens_hsa051342.39259016
13Influenza A_Homo sapiens_hsa051642.30778118
14TNF signaling pathway_Homo sapiens_hsa046682.25572298
15Pertussis_Homo sapiens_hsa051332.23473337
16African trypanosomiasis_Homo sapiens_hsa051432.19810132
17Staphylococcus aureus infection_Homo sapiens_hsa051502.16490358
18Rheumatoid arthritis_Homo sapiens_hsa053232.16393708
19Osteoclast differentiation_Homo sapiens_hsa043802.10235479
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02030147
21Herpes simplex infection_Homo sapiens_hsa051682.00352694
22Tuberculosis_Homo sapiens_hsa051521.92786243
23* Autoimmune thyroid disease_Homo sapiens_hsa053201.62661833
24* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.61326044
25* Malaria_Homo sapiens_hsa051441.60007756
26* Toxoplasmosis_Homo sapiens_hsa051451.58356116
27Chemokine signaling pathway_Homo sapiens_hsa040621.52175950
28B cell receptor signaling pathway_Homo sapiens_hsa046621.51210023
29Apoptosis_Homo sapiens_hsa042101.48881636
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.48291369
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47401466
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46618204
33Salmonella infection_Homo sapiens_hsa051321.42757595
34* Systemic lupus erythematosus_Homo sapiens_hsa053221.41820796
35Antigen processing and presentation_Homo sapiens_hsa046121.34873217
36Shigellosis_Homo sapiens_hsa051311.24110718
37Hematopoietic cell lineage_Homo sapiens_hsa046401.18830499
38Phagosome_Homo sapiens_hsa041451.18220953
39Hepatitis C_Homo sapiens_hsa051601.16991533
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15067394
41Hepatitis B_Homo sapiens_hsa051611.13728368
42* Viral myocarditis_Homo sapiens_hsa054161.11018389
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00693444
44* Primary immunodeficiency_Homo sapiens_hsa053400.99711923
45Lysosome_Homo sapiens_hsa041420.94841693
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91273538
47* Asthma_Homo sapiens_hsa053100.88242798
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87965935
49Prolactin signaling pathway_Homo sapiens_hsa049170.80672412
50Amoebiasis_Homo sapiens_hsa051460.79599549
51T cell receptor signaling pathway_Homo sapiens_hsa046600.74989830
52Prion diseases_Homo sapiens_hsa050200.68860018
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65281445
54Acute myeloid leukemia_Homo sapiens_hsa052210.65125898
55* Epstein-Barr virus infection_Homo sapiens_hsa051690.65072639
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62560518
57Proteasome_Homo sapiens_hsa030500.61087345
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.59224582
59Small cell lung cancer_Homo sapiens_hsa052220.59088325
60Bladder cancer_Homo sapiens_hsa052190.56964041
61Other glycan degradation_Homo sapiens_hsa005110.56396811
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56222388
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56206340
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.55808584
65Chronic myeloid leukemia_Homo sapiens_hsa052200.52314070
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51710818
67Sphingolipid metabolism_Homo sapiens_hsa006000.48708979
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48667122
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47554534
70Sulfur metabolism_Homo sapiens_hsa009200.44120197
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.43588929
72Viral carcinogenesis_Homo sapiens_hsa052030.43535733
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42759624
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42169243
75Type II diabetes mellitus_Homo sapiens_hsa049300.38417375
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38393368
77* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38193796
78Tryptophan metabolism_Homo sapiens_hsa003800.37837851
79HIF-1 signaling pathway_Homo sapiens_hsa040660.37505355
80Pancreatic cancer_Homo sapiens_hsa052120.34882667
81Fructose and mannose metabolism_Homo sapiens_hsa000510.31620416
82Galactose metabolism_Homo sapiens_hsa000520.30041064
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.29759592
84p53 signaling pathway_Homo sapiens_hsa041150.29503442
85* HTLV-I infection_Homo sapiens_hsa051660.28557599
86Collecting duct acid secretion_Homo sapiens_hsa049660.28503913
87Platelet activation_Homo sapiens_hsa046110.27961461
88* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27941085
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.23799223
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23749065
91Notch signaling pathway_Homo sapiens_hsa043300.22051992
92Dorso-ventral axis formation_Homo sapiens_hsa043200.20932585
93Proteoglycans in cancer_Homo sapiens_hsa052050.18174484
94MicroRNAs in cancer_Homo sapiens_hsa052060.17581560
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17187188
96Complement and coagulation cascades_Homo sapiens_hsa046100.17087035
97Phenylalanine metabolism_Homo sapiens_hsa003600.17006809
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16176256
99Mineral absorption_Homo sapiens_hsa049780.15966249
100MAPK signaling pathway_Homo sapiens_hsa040100.15810728
101Insulin resistance_Homo sapiens_hsa049310.13843499
102FoxO signaling pathway_Homo sapiens_hsa040680.13349703
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.11238094
104Renin-angiotensin system_Homo sapiens_hsa046140.11237236
105VEGF signaling pathway_Homo sapiens_hsa043700.10014293
106PPAR signaling pathway_Homo sapiens_hsa033200.09556484
107Glutathione metabolism_Homo sapiens_hsa004800.07337487
108Prostate cancer_Homo sapiens_hsa052150.06739415
109Endocytosis_Homo sapiens_hsa041440.04376678
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.03722028
111Pentose phosphate pathway_Homo sapiens_hsa000300.01911314
112Pathways in cancer_Homo sapiens_hsa052000.01507510
113Vibrio cholerae infection_Homo sapiens_hsa05110-0.0217139
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0096595
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0063343

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