CD40LG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)9.49537474
2negative T cell selection (GO:0043383)7.83074720
3negative thymic T cell selection (GO:0045060)7.77071039
4positive thymic T cell selection (GO:0045059)7.59173959
5regulation of gamma-delta T cell differentiation (GO:0045586)7.37970027
6regulation of regulatory T cell differentiation (GO:0045589)7.37384238
7positive T cell selection (GO:0043368)6.75860221
8leukocyte aggregation (GO:0070486)6.72032211
9positive regulation of isotype switching (GO:0045830)6.65155022
10thymic T cell selection (GO:0045061)6.62251656
11regulation of gamma-delta T cell activation (GO:0046643)6.57619224
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.35062238
13tolerance induction (GO:0002507)6.33002110
14positive regulation of gamma-delta T cell activation (GO:0046645)6.26009480
15T cell selection (GO:0045058)6.06877233
16response to interleukin-15 (GO:0070672)5.79630534
17cellular response to interleukin-15 (GO:0071350)5.71385939
18positive regulation of DNA recombination (GO:0045911)5.66902618
19regulation of isotype switching (GO:0045191)5.59482069
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.53759483
21negative regulation of cell killing (GO:0031342)5.53759483
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.43458427
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.43038624
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.43038624
25T cell receptor signaling pathway (GO:0050852)5.42044999
26interferon-gamma production (GO:0032609)5.40867387
27T cell costimulation (GO:0031295)5.34361824
28lymphocyte costimulation (GO:0031294)5.30251197
29* regulation of immunoglobulin secretion (GO:0051023)5.23631673
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.20535778
31positive regulation of B cell mediated immunity (GO:0002714)5.19956156
32positive regulation of immunoglobulin mediated immune response (GO:0002891)5.19956156
33positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.18643342
34T cell migration (GO:0072678)5.11897181
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.05573888
36regulation of interleukin-12 biosynthetic process (GO:0045075)4.99867920
37regulation of T cell tolerance induction (GO:0002664)4.82840381
38endothelial cell chemotaxis (GO:0035767)4.82370564
39regulation of alpha-beta T cell proliferation (GO:0046640)4.71004868
40regulation of immunoglobulin mediated immune response (GO:0002889)4.64640122
41regulation of interleukin-2 biosynthetic process (GO:0045076)4.57782040
42regulation of B cell mediated immunity (GO:0002712)4.47676961
43antigen processing and presentation of endogenous antigen (GO:0019883)4.46470378
44antigen receptor-mediated signaling pathway (GO:0050851)4.37567012
45positive regulation of immunoglobulin production (GO:0002639)4.37257479
46positive regulation of alpha-beta T cell proliferation (GO:0046641)4.31941406
47positive regulation of humoral immune response (GO:0002922)4.31915856
48regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.29499602
49positive regulation of granulocyte differentiation (GO:0030854)4.21086088
50tyrosine phosphorylation of STAT protein (GO:0007260)4.18489971
51* regulation of immunoglobulin production (GO:0002637)4.15293068
52alpha-beta T cell differentiation involved in immune response (GO:0002293)4.10182977
53alpha-beta T cell activation involved in immune response (GO:0002287)4.10182977
54T cell differentiation involved in immune response (GO:0002292)4.10182977
55alpha-beta T cell differentiation (GO:0046632)4.09086993
56T cell differentiation (GO:0030217)4.05475213
57positive regulation of interleukin-2 production (GO:0032743)4.04508575
58negative regulation of T cell mediated immunity (GO:0002710)4.02214239
59positive regulation of tolerance induction (GO:0002645)3.95722959
60CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.95179614
61negative regulation of B cell apoptotic process (GO:0002903)3.93801115
62positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.93039094
63regulation of B cell receptor signaling pathway (GO:0050855)3.91047381
64DNA deamination (GO:0045006)3.89338513
65alpha-beta T cell activation (GO:0046631)3.86670095
66positive regulation of T cell differentiation in thymus (GO:0033089)3.86384404
67positive regulation of interleukin-17 production (GO:0032740)3.86163546
68regulation of chronic inflammatory response (GO:0002676)3.85182245
69regulation of T cell receptor signaling pathway (GO:0050856)3.82669635
70regulation of T cell mediated cytotoxicity (GO:0001914)3.81675645
71NIK/NF-kappaB signaling (GO:0038061)3.77977780
72positive regulation of T cell differentiation (GO:0045582)3.70421719
73positive regulation of macrophage differentiation (GO:0045651)3.69985556
74positive regulation of T cell mediated cytotoxicity (GO:0001916)3.64957248
75regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.64413569
76mast cell activation (GO:0045576)3.63722484
77positive regulation of astrocyte differentiation (GO:0048711)3.57973953
78natural killer cell activation (GO:0030101)3.56726511
79sequestering of actin monomers (GO:0042989)3.54083065
80T cell activation (GO:0042110)3.52482321
81positive regulation of natural killer cell differentiation (GO:0032825)3.50661730
82positive regulation of activated T cell proliferation (GO:0042104)3.50239180
83regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.47727870
84positive regulation of T cell activation (GO:0050870)3.47441399
85T cell homeostasis (GO:0043029)3.46898556
86regulation of cell killing (GO:0031341)3.45247672
87regulation of leukocyte mediated cytotoxicity (GO:0001910)3.40824546
88negative regulation of lymphocyte mediated immunity (GO:0002707)3.40259486
89regulation of natural killer cell mediated immunity (GO:0002715)3.40086177
90regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.40086177
91regulation of tolerance induction (GO:0002643)3.39011806
92positive regulation of lymphocyte mediated immunity (GO:0002708)3.36451907
93positive regulation of cell killing (GO:0031343)3.35938508
94regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.35686723
95regulation of response to interferon-gamma (GO:0060330)3.32774643
96positive regulation of lamellipodium assembly (GO:0010592)3.30573465
97CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.30507781
98regulation of interleukin-6 biosynthetic process (GO:0045408)3.29639641
99positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.28721313
100myeloid dendritic cell differentiation (GO:0043011)3.27164645
101dendritic cell chemotaxis (GO:0002407)3.26155978
102tumor necrosis factor-mediated signaling pathway (GO:0033209)3.25259971
103defense response to protozoan (GO:0042832)3.23793873
104positive regulation of T cell migration (GO:2000406)3.22481905
105T-helper cell differentiation (GO:0042093)3.19354167
106CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.19354167
107positive regulation of lymphocyte differentiation (GO:0045621)3.18750020
108cytidine metabolic process (GO:0046087)3.18270572
109cytidine catabolic process (GO:0006216)3.18270572
110cytidine deamination (GO:0009972)3.18270572
111regulation of T cell differentiation (GO:0045580)3.17308248
112positive regulation of defense response to virus by host (GO:0002230)3.15058334
113positive regulation of natural killer cell mediated immunity (GO:0002717)3.14429224
114positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.14429224
115myeloid dendritic cell activation (GO:0001773)3.14354150
116regulation of vitamin D biosynthetic process (GO:0060556)3.14238601
117regulation of lymphocyte mediated immunity (GO:0002706)3.14170293
118antigen processing and presentation via MHC class Ib (GO:0002475)3.13318919
119JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.12122631
120regulation of B cell differentiation (GO:0045577)3.10129750
121regulation of T cell activation (GO:0050863)3.09204417
122activated T cell proliferation (GO:0050798)3.08714028
123dendritic cell migration (GO:0036336)3.08572048
124positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.07695552
125pyrimidine ribonucleoside catabolic process (GO:0046133)3.06608387
126regulation of interleukin-2 production (GO:0032663)3.05901644
127regulation of respiratory burst (GO:0060263)3.05742033
128lymphocyte homeostasis (GO:0002260)3.04101326
129regulation of alpha-beta T cell activation (GO:0046634)3.02724644
130* leukocyte cell-cell adhesion (GO:0007159)3.02447330
131positive regulation of interferon-gamma production (GO:0032729)3.00840186
132regulation of defense response to virus by virus (GO:0050690)3.00212618
133regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99932708
134CD4-positive, alpha-beta T cell activation (GO:0035710)2.95371642
135positive regulation of lymphocyte migration (GO:2000403)2.95191252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.49061763
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.06340538
3* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.46366201
4* RUNX_20019798_ChIP-Seq_JUKART_Human4.03292514
5* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.87613317
6MYC_22102868_ChIP-Seq_BL_Human3.78288678
7* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.58000437
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.54408632
9MYB_26560356_Chip-Seq_TH2_Human3.47821839
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.45780662
11NOTCH1_21737748_ChIP-Seq_TLL_Human3.14580925
12* MAF_26560356_Chip-Seq_TH1_Human3.11585033
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07320540
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00671733
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.82793325
16UTX_26944678_Chip-Seq_JUKART_Human2.79579106
17MYB_26560356_Chip-Seq_TH1_Human2.76821953
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72992237
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.37904986
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37814930
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.24621523
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18619778
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15832227
24GATA3_27048872_Chip-Seq_THYMUS_Human2.14217337
25* MAF_26560356_Chip-Seq_TH2_Human2.07084774
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.04173103
27* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00328100
28TCF7_22412390_ChIP-Seq_EML_Mouse1.98812859
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97205849
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.89921732
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.85563937
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85022763
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81404015
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79375791
35VDR_21846776_ChIP-Seq_THP-1_Human1.78572642
36KDM2B_26808549_Chip-Seq_DND41_Human1.76707866
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76707225
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72249493
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70052359
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68915037
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66124573
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65801919
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.64711159
44RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.60773866
45E2F7_22180533_ChIP-Seq_HELA_Human1.59648904
46VDR_24763502_ChIP-Seq_THP-1_Human1.59245105
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.57999063
48SPI1_23547873_ChIP-Seq_NB4_Human1.51421712
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46187319
50GATA1_22025678_ChIP-Seq_K562_Human1.45529190
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43095437
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.41554033
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.36440409
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35360543
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34360499
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32995101
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29451405
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.28371033
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27633869
60SCL_19346495_ChIP-Seq_HPC-7_Human1.23333263
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21511925
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21204850
63GATA3_26560356_Chip-Seq_TH2_Human1.19039298
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.18467770
65SPI1_23127762_ChIP-Seq_K562_Human1.17360785
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14586510
67VDR_23849224_ChIP-Seq_CD4+_Human1.10650532
68PU_27001747_Chip-Seq_BMDM_Mouse1.09088546
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08215286
70GATA3_26560356_Chip-Seq_TH1_Human1.06950288
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05627364
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04073608
73CIITA_25753668_ChIP-Seq_RAJI_Human1.02396194
74FOXP3_21729870_ChIP-Seq_TREG_Human1.01622238
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00586916
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99976628
77SMRT_27268052_Chip-Seq_Bcells_Human0.97072017
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95569378
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95433779
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93532633
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92363468
82NFE2_27457419_Chip-Seq_LIVER_Mouse0.91759443
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91304523
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91084919
85ELK1_19687146_ChIP-ChIP_HELA_Human0.91044647
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88620957
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87993231
88GATA1_19941827_ChIP-Seq_MEL_Mouse0.86581431
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85826034
90RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84754510
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84535673
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82988126
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82621716
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82093330
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81637157
96SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.81283258
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80103126
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79987409
99EST1_17652178_ChIP-ChIP_JURKAT_Human0.78246819
100HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77258371
101FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76817108
102HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76712802
103NCOR1_26117541_ChIP-Seq_K562_Human0.76566452
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74155459
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73360283
106EZH2_27294783_Chip-Seq_NPCs_Mouse0.73307959
107P300_27268052_Chip-Seq_Bcells_Human0.72741729
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72230810
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72023356
110* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.69857417
111BCL6_27268052_Chip-Seq_Bcells_Human0.69220774
112LXR_22292898_ChIP-Seq_THP-1_Human0.68418199
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.68116497
114NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.67594695
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67512666
116* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66954474
117STAT1_20625510_ChIP-Seq_HELA_Human0.66873856
118MYC_18555785_ChIP-Seq_MESCs_Mouse0.66336065
119VDR_24787735_ChIP-Seq_THP-1_Human0.66204445
120* FLI1_21867929_ChIP-Seq_CD8_Mouse0.65015798
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.64480731
122MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.64428291
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.63291686
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.62653636
125TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.62524488
126RACK7_27058665_Chip-Seq_MCF-7_Human0.61943823
127CTCF_27219007_Chip-Seq_ERYTHROID_Human0.61899561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.72884899
2MP0005671_abnormal_response_to5.50223920
3MP0003300_gastrointestinal_ulcer4.53594598
4MP0001853_heart_inflammation3.49604713
5* MP0000685_abnormal_immune_system3.40002311
6MP0009333_abnormal_splenocyte_physiolog3.15273371
7MP0003436_decreased_susceptibility_to3.10104406
8MP0002405_respiratory_system_inflammati2.98008289
9MP0003866_abnormal_defecation2.97178281
10* MP0001835_abnormal_antigen_presentation2.96142327
11* MP0005000_abnormal_immune_tolerance2.82875752
12* MP0001800_abnormal_humoral_immune2.82236979
13MP0006082_CNS_inflammation2.77463846
14* MP0001790_abnormal_immune_system2.73010328
15* MP0005387_immune_system_phenotype2.73010328
16MP0003724_increased_susceptibility_to2.70816562
17MP0002166_altered_tumor_susceptibility2.68684026
18MP0009785_altered_susceptibility_to2.66406746
19* MP0002723_abnormal_immune_serum2.61799584
20* MP0002398_abnormal_bone_marrow2.58003700
21* MP0002420_abnormal_adaptive_immunity2.51138517
22MP0004510_myositis2.49650070
23* MP0001819_abnormal_immune_cell2.46681233
24MP0000703_abnormal_thymus_morphology2.42486501
25MP0000465_gastrointestinal_hemorrhage2.40651564
26MP0004947_skin_inflammation2.32478303
27* MP0002452_abnormal_antigen_presenting2.24156223
28* MP0005025_abnormal_response_to2.21282620
29MP0002933_joint_inflammation2.20801212
30* MP0000716_abnormal_immune_system2.20002341
31MP0010155_abnormal_intestine_physiology2.16171104
32MP0002006_tumorigenesis2.14104697
33* MP0002722_abnormal_immune_system2.01136424
34* MP0000689_abnormal_spleen_morphology1.99631923
35MP0003303_peritoneal_inflammation1.99490394
36MP0001873_stomach_inflammation1.88483720
37MP0002396_abnormal_hematopoietic_system1.82168927
38* MP0002429_abnormal_blood_cell1.76084665
39MP0002148_abnormal_hypersensitivity_rea1.72987155
40MP0001845_abnormal_inflammatory_respons1.62820112
41MP0005423_abnormal_somatic_nervous1.59055677
42MP0002419_abnormal_innate_immunity1.52160763
43* MP0000604_amyloidosis1.49114181
44MP0001533_abnormal_skeleton_physiology1.48393536
45MP0004808_abnormal_hematopoietic_stem1.46611945
46MP0002277_abnormal_respiratory_mucosa1.42112160
47MP0002138_abnormal_hepatobiliary_system1.35056381
48MP0010352_gastrointestinal_tract_polyps1.34490058
49MP0005464_abnormal_platelet_physiology1.30181007
50MP0001851_eye_inflammation1.26001801
51MP0000858_altered_metastatic_potential1.20956457
52MP0004381_abnormal_hair_follicle1.18429731
53MP0005310_abnormal_salivary_gland1.16123082
54MP0000372_irregular_coat_pigmentation1.06114143
55MP0002998_abnormal_bone_remodeling1.03329385
56MP0003448_altered_tumor_morphology1.01006245
57MP0008469_abnormal_protein_level1.00681575
58MP0008057_abnormal_DNA_replication0.97458829
59MP0002822_catalepsy0.92219213
60MP0005023_abnormal_wound_healing0.91316345
61MP0008961_abnormal_basal_metabolism0.88662120
62MP0001881_abnormal_mammary_gland0.87597125
63MP0002132_abnormal_respiratory_system0.87111983
64MP0004742_abnormal_vestibular_system0.86388247
65MP0008877_abnormal_DNA_methylation0.84909973
66MP0002019_abnormal_tumor_incidence0.84134567
67MP0003453_abnormal_keratinocyte_physiol0.81355071
68MP0000609_abnormal_liver_physiology0.78005376
69MP0001986_abnormal_taste_sensitivity0.77248963
70MP0001348_abnormal_lacrimal_gland0.76052998
71MP0005076_abnormal_cell_differentiation0.75628898
72MP0009764_decreased_sensitivity_to0.74955934
73MP0003045_fibrosis0.73373297
74MP0000490_abnormal_crypts_of0.72551939
75MP0009763_increased_sensitivity_to0.71353980
76MP0005166_decreased_susceptibility_to0.71060747
77MP0002009_preneoplasia0.70858927
78MP0008872_abnormal_physiological_respon0.69584872
79MP0000627_abnormal_mammary_gland0.67789695
80MP0001545_abnormal_hematopoietic_system0.66837806
81MP0005397_hematopoietic_system_phenotyp0.66837806
82MP0001243_abnormal_dermal_layer0.66001757
83MP0005390_skeleton_phenotype0.63288164
84MP0002163_abnormal_gland_morphology0.61650905
85MP0001919_abnormal_reproductive_system0.61590800
86MP0001958_emphysema0.61177848
87MP0009765_abnormal_xenobiotic_induced0.60970552
88MP0000249_abnormal_blood_vessel0.60581516
89MP0004130_abnormal_muscle_cell0.59396957
90* MP0003795_abnormal_bone_structure0.59153659
91MP0008569_lethality_at_weaning0.58507440
92MP0005381_digestive/alimentary_phenotyp0.57725652
93MP0004142_abnormal_muscle_tone0.56290986
94MP0002102_abnormal_ear_morphology0.56196049
95MP0008875_abnormal_xenobiotic_pharmacok0.55899587
96MP0002693_abnormal_pancreas_physiology0.55247311
97MP0001191_abnormal_skin_condition0.54919885
98MP0000015_abnormal_ear_pigmentation0.54522966
99MP0005165_increased_susceptibility_to0.53066400
100MP0003943_abnormal_hepatobiliary_system0.52182348
101MP0004264_abnormal_extraembryonic_tissu0.51129452
102MP0003252_abnormal_bile_duct0.49444290
103MP0004782_abnormal_surfactant_physiolog0.48473332
104MP0001216_abnormal_epidermal_layer0.47081693
105MP0000477_abnormal_intestine_morphology0.45639176
106MP0005075_abnormal_melanosome_morpholog0.45111647
107MP0001765_abnormal_ion_homeostasis0.44618636
108MP0002876_abnormal_thyroid_physiology0.44277666
109MP0003786_premature_aging0.44277081
110MP0003806_abnormal_nucleotide_metabolis0.44244200
111MP0008007_abnormal_cellular_replicative0.41081699
112MP0003077_abnormal_cell_cycle0.40811890
113MP0003828_pulmonary_edema0.39718493
114MP0001663_abnormal_digestive_system0.39420917
115MP0005083_abnormal_biliary_tract0.38708292
116MP0000920_abnormal_myelination0.38673837
117MP0002136_abnormal_kidney_physiology0.38542483
118MP0004883_abnormal_blood_vessel0.36141472
119MP0001501_abnormal_sleep_pattern0.35098785
120MP0002083_premature_death0.34162780
121MP0008873_increased_physiological_sensi0.33929624
122MP0000598_abnormal_liver_morphology0.33384747
123MP0000367_abnormal_coat/_hair0.33186430
124MP0010234_abnormal_vibrissa_follicle0.31155816
125MP0000613_abnormal_salivary_gland0.28284949

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)7.21311863
2T lymphocytopenia (HP:0005403)6.96813572
3Abnormality of T cell number (HP:0011839)6.77876605
4Elevated erythrocyte sedimentation rate (HP:0003565)6.42290803
5Combined immunodeficiency (HP:0005387)6.33720059
6* Stomatitis (HP:0010280)6.21141853
7Eczematoid dermatitis (HP:0000976)5.76564894
8Recurrent bronchitis (HP:0002837)5.30274503
9IgM deficiency (HP:0002850)5.22030197
10Increased density of long bones (HP:0006392)5.10641937
11* IgG deficiency (HP:0004315)5.09187827
12* Abnormality of T cells (HP:0002843)4.85369943
13Chronic diarrhea (HP:0002028)4.77939336
14Recurrent fungal infections (HP:0002841)4.76846716
15Panhypogammaglobulinemia (HP:0003139)4.76692375
16Gastrointestinal infarctions (HP:0005244)4.51413357
17Nasal polyposis (HP:0100582)4.42223506
18B lymphocytopenia (HP:0010976)4.39303434
19Abnormality of B cell number (HP:0010975)4.39303434
20Chronic otitis media (HP:0000389)3.96141953
21Recurrent cutaneous fungal infections (HP:0011370)3.67160702
22Chronic mucocutaneous candidiasis (HP:0002728)3.67160702
23Abnormality of the nasal mucosa (HP:0000433)3.64297457
24Persistence of primary teeth (HP:0006335)3.60005300
25Autoimmune hemolytic anemia (HP:0001890)3.59095742
26Joint swelling (HP:0001386)3.54390631
27Abnormality of eosinophils (HP:0001879)3.52051911
28Lymphopenia (HP:0001888)3.47091169
29Abnormality of the fingertips (HP:0001211)3.44675824
30Abnormality of cells of the lymphoid lineage (HP:0012140)3.38157228
31Leukocytosis (HP:0001974)3.33965536
32Myositis (HP:0100614)3.32863009
33Recurrent viral infections (HP:0004429)3.29333251
34Thrombocytosis (HP:0001894)3.19575794
35Thyroiditis (HP:0100646)3.16419549
36Recurrent abscess formation (HP:0002722)3.11615828
37Keratoconjunctivitis (HP:0001096)3.05984634
38Recurrent bacterial skin infections (HP:0005406)3.03247002
39Vasculitis (HP:0002633)3.01898567
40Mediastinal lymphadenopathy (HP:0100721)3.00357085
41* Abnormality of T cell physiology (HP:0011840)2.97364675
42Recurrent sinusitis (HP:0011108)2.96431118
43Bronchitis (HP:0012387)2.95993933
44Arterial thrombosis (HP:0004420)2.93103518
45Lymphoma (HP:0002665)2.92107918
46* IgA deficiency (HP:0002720)2.89538279
47Prolonged bleeding time (HP:0003010)2.88854732
48Chest pain (HP:0100749)2.87133144
49Hemoptysis (HP:0002105)2.79571209
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.77355256
51Amaurosis fugax (HP:0100576)2.75442494
52Eosinophilia (HP:0001880)2.69294751
53Pustule (HP:0200039)2.68462707
54Retrobulbar optic neuritis (HP:0100654)2.67076816
55Optic neuritis (HP:0100653)2.67076816
56Stomach cancer (HP:0012126)2.64660056
57Pulmonary infiltrates (HP:0002113)2.62825213
58Abnormality of incisor morphology (HP:0011063)2.56924214
59Hypoplasia of the thymus (HP:0000778)2.50222265
60Chronic obstructive pulmonary disease (HP:0006510)2.46962438
61Obstructive lung disease (HP:0006536)2.46962438
62* Increased IgM level (HP:0003496)2.45221281
63Abnormality of the prostate (HP:0008775)2.39931250
64Granulocytopenia (HP:0001913)2.38202504
65Gastrointestinal stroma tumor (HP:0100723)2.37367430
66Orchitis (HP:0100796)2.35957818
67Ureteral stenosis (HP:0000071)2.35579799
68Fatigue (HP:0012378)2.34413245
69Meningitis (HP:0001287)2.34129809
70Diplopia (HP:0000651)2.26799342
71Abnormality of binocular vision (HP:0011514)2.26799342
72Keratitis (HP:0000491)2.25097718
73Reduced subcutaneous adipose tissue (HP:0003758)2.22791262
74Aplastic anemia (HP:0001915)2.22186165
75Hypochromic anemia (HP:0001931)2.19082732
76Episodic fever (HP:0001954)2.18960140
77Pulmonary embolism (HP:0002204)2.15841754
78Emphysema (HP:0002097)2.15606479
79Gingival bleeding (HP:0000225)2.14313014
80Abnormality of the endocardium (HP:0004306)2.14306284
81Pancytopenia (HP:0001876)2.13274149
82Papilledema (HP:0001085)2.11875311
83Ureteral obstruction (HP:0006000)2.10705184
84Recurrent otitis media (HP:0000403)2.10702145
85Recurrent skin infections (HP:0001581)2.10298842
86Pulmonary fibrosis (HP:0002206)2.07685084
87Somatic mutation (HP:0001428)2.07496918
88Gangrene (HP:0100758)2.05731565
89Spontaneous hematomas (HP:0007420)2.05601870
90Abnormality of macrophages (HP:0004311)2.03813048
91Epistaxis (HP:0000421)2.01392735
92* Hypergammaglobulinemia (HP:0010702)2.00645167
93Cutaneous melanoma (HP:0012056)2.00263033
94Peripheral hypomyelination (HP:0007182)1.97747830
95Inflammation of the large intestine (HP:0002037)1.95168904
96Myocardial infarction (HP:0001658)1.94813286
97Basal cell carcinoma (HP:0002671)1.94416211
98Verrucae (HP:0200043)1.93852215
99Papilloma (HP:0012740)1.93852215
100Increased IgE level (HP:0003212)1.91411520
101Encephalitis (HP:0002383)1.90415482
102Frequent falls (HP:0002359)1.87272794
103Chronic sinusitis (HP:0011109)1.86833961
104Gastrointestinal inflammation (HP:0004386)1.86335154
105Hypochromic microcytic anemia (HP:0004840)1.85453878
106Polyneuropathy (HP:0001271)1.82533433
107Alveolar cell carcinoma (HP:0006519)1.82273012
108Autoimmune thrombocytopenia (HP:0001973)1.82263226
109Hypoproteinemia (HP:0003075)1.82095127
110Keratoconjunctivitis sicca (HP:0001097)1.82001625
111Agammaglobulinemia (HP:0004432)1.81973000
112Amyotrophic lateral sclerosis (HP:0007354)1.81802524
113* Neutropenia (HP:0001875)1.81127537
114Acute hepatic failure (HP:0006554)1.80503469
115Anorexia (HP:0002039)1.80253582
116Abnormal pupillary function (HP:0007686)1.80115180
117Arthralgia (HP:0002829)1.79944725
118Prostate neoplasm (HP:0100787)1.79445870
119Abnormality of male internal genitalia (HP:0000022)1.78576203
120Skin rash (HP:0000988)1.77150312
121Abnormal platelet volume (HP:0011876)1.77095063
122Abnormality of the pleura (HP:0002103)1.75764244
123Cheilitis (HP:0100825)1.73789615
124Severe visual impairment (HP:0001141)1.73295633
125Oral leukoplakia (HP:0002745)1.71929191
126Bronchiectasis (HP:0002110)1.70386413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.87561237
2MAP4K16.54327217
3TAOK35.42406039
4ZAP704.37641777
5ITK3.30351666
6JAK32.93446101
7TESK22.75627897
8MAP3K122.62327052
9IKBKE2.34371038
10MAP3K142.29673492
11FGFR42.21211617
12PRPF4B1.98186591
13CAMKK21.95091864
14KDR1.92754627
15TEC1.92050059
16LCK1.88934670
17RIPK41.84203820
18MAP3K111.78604924
19TYK21.74937639
20STK101.72232994
21IKBKB1.61259003
22NUAK11.54771002
23TBK11.48907589
24JAK11.46392517
25NLK1.43399864
26TAOK11.38200101
27HCK1.37154578
28CHUK1.36891895
29PRKCQ1.28180849
30PIM21.25832396
31FGFR31.24158664
32CAMKK11.23996104
33TESK11.23776072
34BTK1.17625000
35SYK1.14587686
36GRK61.12975839
37MAP2K21.07231147
38MAP3K101.07069445
39CSK1.05091314
40MAP2K31.00041106
41PRKCH1.00008945
42ADRBK20.95507795
43CSF1R0.95329461
44FGFR10.95089054
45RPS6KA40.94879462
46MAP3K130.92585447
47MAP3K70.87300020
48EEF2K0.83951828
49JAK20.81182127
50MAPK110.78693894
51SIK30.77447882
52EIF2AK10.77056928
53RPS6KA50.74114586
54PIM10.72934225
55LYN0.71908775
56TAOK20.71736000
57MST40.70858061
58FGR0.68859696
59LRRK20.68318346
60NME20.68299825
61MAP3K30.66101492
62SIK20.62849809
63PKN20.61378541
64CDK120.55949291
65TYRO30.54553377
66WNK10.51977024
67RAF10.51687354
68PDGFRB0.49157711
69TGFBR20.47750702
70SIK10.47396408
71EPHA30.47281201
72MARK30.46407750
73LIMK10.46384333
74TNK20.45926360
75IRAK10.45628324
76BLK0.44627048
77TLK10.43678288
78MAP3K10.43483466
79NTRK20.43449186
80INSR0.43257305
81IGF1R0.42932147
82RPS6KA10.42761756
83EIF2AK30.42579357
84MAP4K20.42342357
85IRAK40.41552401
86TRIB30.41186262
87MYLK0.40971662
88ROCK20.38603632
89CLK10.36308052
90RPS6KA60.36211277
91EPHB10.35743606
92FYN0.35284262
93PTK2B0.35235396
94SRPK10.34597576
95PDK10.34274755
96TSSK60.33368568
97FES0.33357654
98STK380.32644666
99MATK0.32344314
100BRD40.32153688
101KIT0.32068485
102CDK80.31833199
103ALK0.31715658
104TRPM70.31658671
105PAK30.31082271
106MARK20.30617065
107CAMK40.29186313
108TTN0.28691253
109MELK0.28242246
110PINK10.28194264
111PIK3CG0.27326487
112PTK60.26910995
113CDK90.26771755
114MAPKAPK20.26185088
115PIK3CA0.25599629
116MAP3K80.24471741
117NEK60.24332016
118RPS6KC10.23143982
119RPS6KL10.23143982
120NME10.22485485
121PASK0.21426052
122DAPK30.20241705
123MAP3K50.19584298
124HIPK20.19554961
125MAPK80.18527315
126CDK40.18310838
127MST1R0.17656896
128MAPK30.16488226
129DAPK10.16222651
130MAP2K60.16078835

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053405.04013161
2* Allograft rejection_Homo sapiens_hsa053304.35080172
3Graft-versus-host disease_Homo sapiens_hsa053324.30443950
4* T cell receptor signaling pathway_Homo sapiens_hsa046604.25865679
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.81453726
6* Intestinal immune network for IgA production_Homo sapiens_hsa046723.25581145
7* Autoimmune thyroid disease_Homo sapiens_hsa053203.11149443
8Type I diabetes mellitus_Homo sapiens_hsa049403.04055135
9* NF-kappa B signaling pathway_Homo sapiens_hsa040642.95130275
10Measles_Homo sapiens_hsa051622.85640093
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.72091532
12Hematopoietic cell lineage_Homo sapiens_hsa046402.09494539
13Antigen processing and presentation_Homo sapiens_hsa046122.01689156
14Osteoclast differentiation_Homo sapiens_hsa043801.95102670
15* Asthma_Homo sapiens_hsa053101.91247760
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.89291826
17Leishmaniasis_Homo sapiens_hsa051401.83973899
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64149941
19* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.56406578
20* Viral myocarditis_Homo sapiens_hsa054161.55659043
21Proteasome_Homo sapiens_hsa030501.54915303
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54783694
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52588664
24Herpes simplex infection_Homo sapiens_hsa051681.49087846
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41452548
26B cell receptor signaling pathway_Homo sapiens_hsa046621.39053243
27Regulation of autophagy_Homo sapiens_hsa041401.36807389
28Vitamin B6 metabolism_Homo sapiens_hsa007501.36374831
29TNF signaling pathway_Homo sapiens_hsa046681.35275774
30Hepatitis B_Homo sapiens_hsa051611.31165225
31Acute myeloid leukemia_Homo sapiens_hsa052211.25713321
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25371467
33* Toxoplasmosis_Homo sapiens_hsa051451.21045455
34HTLV-I infection_Homo sapiens_hsa051661.20639921
35African trypanosomiasis_Homo sapiens_hsa051431.18088069
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04406133
37Chemokine signaling pathway_Homo sapiens_hsa040621.03071258
38Prolactin signaling pathway_Homo sapiens_hsa049171.02655792
39Shigellosis_Homo sapiens_hsa051310.99061864
40Pancreatic cancer_Homo sapiens_hsa052120.95025336
41* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94332742
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93252546
43Apoptosis_Homo sapiens_hsa042100.93074776
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.91656580
45Legionellosis_Homo sapiens_hsa051340.86795592
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84971924
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83755891
48Caffeine metabolism_Homo sapiens_hsa002320.82604766
49Chronic myeloid leukemia_Homo sapiens_hsa052200.80570770
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78889947
51Influenza A_Homo sapiens_hsa051640.78326784
52VEGF signaling pathway_Homo sapiens_hsa043700.77756175
53Colorectal cancer_Homo sapiens_hsa052100.77468319
54Viral carcinogenesis_Homo sapiens_hsa052030.77168569
55Linoleic acid metabolism_Homo sapiens_hsa005910.74140031
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72595109
57Epstein-Barr virus infection_Homo sapiens_hsa051690.71610342
58Ribosome_Homo sapiens_hsa030100.70961809
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.64960161
60Hepatitis C_Homo sapiens_hsa051600.64482634
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61395371
62Platelet activation_Homo sapiens_hsa046110.58517489
63MAPK signaling pathway_Homo sapiens_hsa040100.58131928
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57970866
65Spliceosome_Homo sapiens_hsa030400.55573690
66Tuberculosis_Homo sapiens_hsa051520.55513571
67Basal transcription factors_Homo sapiens_hsa030220.53188061
68RNA polymerase_Homo sapiens_hsa030200.52023071
69Rheumatoid arthritis_Homo sapiens_hsa053230.48981263
70Pertussis_Homo sapiens_hsa051330.48465692
71Small cell lung cancer_Homo sapiens_hsa052220.48192175
72Salmonella infection_Homo sapiens_hsa051320.48183736
73Staphylococcus aureus infection_Homo sapiens_hsa051500.44439643
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44328888
75RNA degradation_Homo sapiens_hsa030180.43929698
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.42722218
77Arachidonic acid metabolism_Homo sapiens_hsa005900.41868775
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38275392
79Insulin resistance_Homo sapiens_hsa049310.37998696
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34399852
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29441669
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29184861
83Protein export_Homo sapiens_hsa030600.29119238
84p53 signaling pathway_Homo sapiens_hsa041150.28564096
85Endocytosis_Homo sapiens_hsa041440.27944447
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.27457811
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26823243
88Long-term potentiation_Homo sapiens_hsa047200.24584749
89Rap1 signaling pathway_Homo sapiens_hsa040150.23487777
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21865696
91* Malaria_Homo sapiens_hsa051440.21482825
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20221757
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18972442
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18722055
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18050982
96Inositol phosphate metabolism_Homo sapiens_hsa005620.17451509
97FoxO signaling pathway_Homo sapiens_hsa040680.17346224
98Thyroid cancer_Homo sapiens_hsa052160.16736786
99mRNA surveillance pathway_Homo sapiens_hsa030150.16674291
100Pathways in cancer_Homo sapiens_hsa052000.16562482
101Renin secretion_Homo sapiens_hsa049240.14302071
102mTOR signaling pathway_Homo sapiens_hsa041500.14092001
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.12267395
104Non-small cell lung cancer_Homo sapiens_hsa052230.11712692
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11386952
106Prostate cancer_Homo sapiens_hsa052150.11057648
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10444642
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10310185
109Circadian rhythm_Homo sapiens_hsa047100.10229422
110Oxytocin signaling pathway_Homo sapiens_hsa049210.10028500
111Morphine addiction_Homo sapiens_hsa050320.09896135
112Ras signaling pathway_Homo sapiens_hsa040140.08950812
113RNA transport_Homo sapiens_hsa030130.07458542
114Pentose phosphate pathway_Homo sapiens_hsa000300.06993449
115Renal cell carcinoma_Homo sapiens_hsa052110.06586217
116MicroRNAs in cancer_Homo sapiens_hsa052060.06499747
117HIF-1 signaling pathway_Homo sapiens_hsa040660.06213154
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.05941553
119Type II diabetes mellitus_Homo sapiens_hsa049300.02338273
120Notch signaling pathway_Homo sapiens_hsa043300.01671524
121Choline metabolism in cancer_Homo sapiens_hsa052310.01422218
122Adherens junction_Homo sapiens_hsa04520-0.0172867
123Endometrial cancer_Homo sapiens_hsa05213-0.0080830

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