CD46P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ethanol (GO:0071361)6.27703508
2positive regulation of cAMP-mediated signaling (GO:0043950)5.58110494
3production of molecular mediator involved in inflammatory response (GO:0002532)5.15171256
4purine-containing compound salvage (GO:0043101)4.99042074
5regulation of interferon-beta biosynthetic process (GO:0045357)4.85303576
6regulation of mononuclear cell migration (GO:0071675)4.50203909
7protoporphyrinogen IX metabolic process (GO:0046501)4.48293340
8iron ion import (GO:0097286)4.36615814
9positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.28439683
10erythrocyte maturation (GO:0043249)4.22144595
11T cell migration (GO:0072678)4.15375104
12NAD biosynthetic process (GO:0009435)3.95500069
13microglial cell activation (GO:0001774)3.87347813
14histone mRNA catabolic process (GO:0071044)3.85881031
15regulation of macrophage chemotaxis (GO:0010758)3.85628948
16phagocytosis, recognition (GO:0006910)3.84402940
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80818547
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.80818547
19modulation by symbiont of host immune response (GO:0052553)3.80818547
20positive regulation by symbiont of host defense response (GO:0052509)3.80818547
21modulation by symbiont of host defense response (GO:0052031)3.80818547
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80818547
23macrophage activation involved in immune response (GO:0002281)3.66460960
24protoporphyrinogen IX biosynthetic process (GO:0006782)3.58409363
25positive regulation of mitotic sister chromatid separation (GO:1901970)3.56756829
26positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.56756829
27positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.56756829
28spermatid nucleus differentiation (GO:0007289)3.54408810
29neutrophil activation involved in immune response (GO:0002283)3.50469656
30oxygen transport (GO:0015671)3.46285224
31response to host immune response (GO:0052572)3.43614316
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.43614316
33urate metabolic process (GO:0046415)3.38088695
34cellular response to exogenous dsRNA (GO:0071360)3.31550115
35nicotinamide nucleotide biosynthetic process (GO:0019359)3.31506091
36pyridine nucleotide biosynthetic process (GO:0019363)3.31506091
37regulation of cAMP-mediated signaling (GO:0043949)3.30175748
38regulation of lymphocyte chemotaxis (GO:1901623)3.29570389
39immunoglobulin mediated immune response (GO:0016064)3.29148018
40mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.28388866
41positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.28388866
42positive regulation of granulocyte differentiation (GO:0030854)3.27412525
43diterpenoid biosynthetic process (GO:0016102)3.24069754
44porphyrin-containing compound biosynthetic process (GO:0006779)3.23232194
45glycosphingolipid biosynthetic process (GO:0006688)3.18469108
46cellular extravasation (GO:0045123)3.15622964
47detection of molecule of bacterial origin (GO:0032490)3.14243050
48response to interferon-beta (GO:0035456)3.12117121
49lymphocyte chemotaxis (GO:0048247)3.11560799
50gas transport (GO:0015669)3.09990280
51B cell mediated immunity (GO:0019724)3.04073424
52positive regulation of interferon-alpha production (GO:0032727)3.03031828
53positive regulation of histone H3-K4 methylation (GO:0051571)3.01111604
54tetrapyrrole biosynthetic process (GO:0033014)3.01044475
55erythrocyte development (GO:0048821)3.00847489
56regulation of transmission of nerve impulse (GO:0051969)2.99166857
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.97681721
58response to host (GO:0075136)2.97681721
59response to host defenses (GO:0052200)2.97681721
60regulation of axon regeneration (GO:0048679)2.94926543
61regulation of neuron projection regeneration (GO:0070570)2.94926543
62platelet dense granule organization (GO:0060155)2.93421002
63positive regulation of viral genome replication (GO:0045070)2.92771242
64positive regulation of toll-like receptor signaling pathway (GO:0034123)2.92333167
65regulation of oxidative phosphorylation (GO:0002082)2.89818873
66regulation of interferon-alpha production (GO:0032647)2.88836695
67positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.81897171
68response to methylmercury (GO:0051597)2.80714035
69regulation of memory T cell differentiation (GO:0043380)2.80288719
70positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.77963440
71porphyrin-containing compound metabolic process (GO:0006778)2.76249790
72definitive hemopoiesis (GO:0060216)2.75704305
73acrosome assembly (GO:0001675)2.73965228
74regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.73283352
75positive regulation of mast cell activation (GO:0033005)2.71257182
76hepatocyte apoptotic process (GO:0097284)2.70717390
77positive regulation of acute inflammatory response (GO:0002675)2.69177020
78regulation of defense response to virus by host (GO:0050691)2.68559185
79positive regulation of lymphocyte migration (GO:2000403)2.68070283
80positive regulation of steroid hormone secretion (GO:2000833)2.67706013
81macrophage activation (GO:0042116)2.67156751
82positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.65202453
83terpenoid biosynthetic process (GO:0016114)2.65048996
84somatic hypermutation of immunoglobulin genes (GO:0016446)2.63663015
85somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63663015
86centriole replication (GO:0007099)2.62759044
87DNA topological change (GO:0006265)2.61695231
88negative regulation of fatty acid biosynthetic process (GO:0045717)2.61331275
89monocyte chemotaxis (GO:0002548)2.60573680
90activated T cell proliferation (GO:0050798)2.60297368
91myeloid cell activation involved in immune response (GO:0002275)2.59972428
92positive regulation of neurological system process (GO:0031646)2.59532291
93cellular response to interferon-beta (GO:0035458)2.58078025
94regulation of hypersensitivity (GO:0002883)2.58046869
95monoubiquitinated protein deubiquitination (GO:0035520)2.56467740
96dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.53397276
97regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.52292765
98positive regulation of defense response to virus by host (GO:0002230)2.51530584
99eosinophil chemotaxis (GO:0048245)11.3265369
100eosinophil migration (GO:0072677)10.1811598

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.80800739
2GATA1_22025678_ChIP-Seq_K562_Human5.11431733
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.71294238
4VDR_22108803_ChIP-Seq_LS180_Human3.20571947
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.01067008
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.91206961
7GATA1_19941826_ChIP-Seq_K562_Human2.81271228
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.75879353
9SCL_19346495_ChIP-Seq_HPC-7_Human2.73728284
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.69656269
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.66526249
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.65885643
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42315666
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.27790148
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25906996
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.22563415
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.17145901
18GATA2_19941826_ChIP-Seq_K562_Human2.08376840
19IGF1R_20145208_ChIP-Seq_DFB_Human2.04752214
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03280329
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00279732
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95402071
23ER_23166858_ChIP-Seq_MCF-7_Human1.89590522
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78670306
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.77432961
26SPI1_23127762_ChIP-Seq_K562_Human1.75964459
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62818940
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62527925
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56850151
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52563104
31TP53_22573176_ChIP-Seq_HFKS_Human1.49671429
32KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.46278422
33NCOR1_26117541_ChIP-Seq_K562_Human1.39874793
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39222350
35SALL4_22934838_ChIP-ChIP_CD34+_Human1.37453357
36SPI1_23547873_ChIP-Seq_NB4_Human1.36727229
37IRF1_19129219_ChIP-ChIP_H3396_Human1.34159132
38TFEB_21752829_ChIP-Seq_HELA_Human1.34050952
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33254930
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32534187
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31544038
42GATA3_26560356_Chip-Seq_TH2_Human1.29213027
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26813341
44STAT1_20625510_ChIP-Seq_HELA_Human1.25101391
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23461348
46ZNF274_21170338_ChIP-Seq_K562_Hela1.22766527
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.21834482
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19613684
49MYB_26560356_Chip-Seq_TH2_Human1.19190688
50JUN_21703547_ChIP-Seq_K562_Human1.18494815
51GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.17674811
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17233424
53ELK1_19687146_ChIP-ChIP_HELA_Human1.15302288
54NFYB_21822215_ChIP-Seq_K562_Human1.14499215
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13587931
56TAF15_26573619_Chip-Seq_HEK293_Human1.13413855
57VDR_23849224_ChIP-Seq_CD4+_Human1.11993483
58CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10694450
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08328170
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.08169376
61PHF8_20622853_ChIP-Seq_HELA_Human1.08125900
62HNFA_21074721_ChIP-Seq_CACO-2_Human1.07185179
63VDR_24787735_ChIP-Seq_THP-1_Human1.06496160
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05560850
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05253253
66EWS_26573619_Chip-Seq_HEK293_Human1.04107060
67GATA6_21074721_ChIP-Seq_CACO-2_Human1.03686073
68NFYA_21822215_ChIP-Seq_K562_Human1.02416759
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01717686
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01216965
71CDX2_22108803_ChIP-Seq_LS180_Human1.00839669
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99473547
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98939698
74FOXP3_21729870_ChIP-Seq_TREG_Human0.98538173
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97677350
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97560864
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97088128
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96362243
79GATA3_27048872_Chip-Seq_THYMUS_Human0.96247550
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96095636
81WT1_19549856_ChIP-ChIP_CCG9911_Human0.96004414
82P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95549713
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94885813
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.94885813
85GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94854179
86GATA1_19941827_ChIP-Seq_MEL_Mouse0.93042839
87GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91393134
88RBPJ_21746931_ChIP-Seq_IB4_Human0.90741921
89ERG_20517297_ChIP-Seq_VCAP_Human0.90309178
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89505666
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89382493
92FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89207306
93GATA3_26560356_Chip-Seq_TH1_Human0.88542648
94CBP_20019798_ChIP-Seq_JUKART_Human0.87043913
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87043913
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86242828
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85594663
98TBL1_22424771_ChIP-Seq_293T_Human0.85271263
99DCP1A_22483619_ChIP-Seq_HELA_Human0.84679021
100TCF4_22108803_ChIP-Seq_LS180_Human0.84231588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.18412466
2MP0003656_abnormal_erythrocyte_physiolo4.25540499
3MP0008057_abnormal_DNA_replication3.91930038
4MP0002254_reproductive_system_inflammat3.24293902
5MP0005671_abnormal_response_to2.90219913
6MP0005310_abnormal_salivary_gland2.78632247
7MP0000569_abnormal_digit_pigmentation2.76345846
8MP0001835_abnormal_antigen_presentation2.70702074
9MP0006082_CNS_inflammation2.56463656
10MP0005167_abnormal_blood-brain_barrier2.48019326
11MP0008995_early_reproductive_senescence2.31990073
12MP0008058_abnormal_DNA_repair2.29907135
13MP0002148_abnormal_hypersensitivity_rea2.18638300
14MP0009785_altered_susceptibility_to2.14033466
15MP0000015_abnormal_ear_pigmentation2.13038899
16MP0005083_abnormal_biliary_tract2.08846545
17MP0006054_spinal_hemorrhage2.05458881
18MP0002163_abnormal_gland_morphology2.00371797
19MP0005464_abnormal_platelet_physiology1.86350968
20MP0005000_abnormal_immune_tolerance1.82477336
21MP0003111_abnormal_nucleus_morphology1.77264893
22MP0004019_abnormal_vitamin_homeostasis1.69252146
23MP0005174_abnormal_tail_pigmentation1.67435656
24MP0010094_abnormal_chromosome_stability1.63407905
25MP0005397_hematopoietic_system_phenotyp1.57535863
26MP0001545_abnormal_hematopoietic_system1.57535863
27MP0010307_abnormal_tumor_latency1.56951495
28MP0003786_premature_aging1.53245528
29MP0009697_abnormal_copulation1.50476402
30MP0005379_endocrine/exocrine_gland_phen1.48540800
31MP0003950_abnormal_plasma_membrane1.48516896
32MP0003436_decreased_susceptibility_to1.48274272
33MP0009333_abnormal_splenocyte_physiolog1.45061992
34MP0001919_abnormal_reproductive_system1.44015130
35MP0005451_abnormal_body_composition1.43926545
36MP0003763_abnormal_thymus_physiology1.42969988
37MP0003191_abnormal_cellular_cholesterol1.38676004
38MP0005025_abnormal_response_to1.37111200
39MP0008877_abnormal_DNA_methylation1.36377441
40MP0002139_abnormal_hepatobiliary_system1.32898684
41MP0002132_abnormal_respiratory_system1.30238760
42MP0000685_abnormal_immune_system1.28707733
43MP0002452_abnormal_antigen_presenting1.27685348
44MP0002090_abnormal_vision1.27304549
45MP0005636_abnormal_mineral_homeostasis1.27070164
46MP0000372_irregular_coat_pigmentation1.26552191
47MP0004883_abnormal_blood_vessel1.24875363
48MP0001819_abnormal_immune_cell1.24757997
49MP0001800_abnormal_humoral_immune1.22707681
50MP0002095_abnormal_skin_pigmentation1.22270690
51MP0002723_abnormal_immune_serum1.22061910
52MP0002419_abnormal_innate_immunity1.21958146
53MP0002420_abnormal_adaptive_immunity1.20670614
54MP0005389_reproductive_system_phenotype1.18860278
55MP0003724_increased_susceptibility_to1.18164255
56MP0001845_abnormal_inflammatory_respons1.13108686
57MP0002693_abnormal_pancreas_physiology1.11775055
58MP0008875_abnormal_xenobiotic_pharmacok1.08620092
59MP0001790_abnormal_immune_system1.06885426
60MP0005387_immune_system_phenotype1.06885426
61MP0005647_abnormal_sex_gland1.06170162
62MP0002166_altered_tumor_susceptibility1.05961995
63MP0008872_abnormal_physiological_respon1.03819996
64MP0001873_stomach_inflammation1.03699762
65MP0005164_abnormal_response_to1.02371128
66MP0005646_abnormal_pituitary_gland0.99506988
67MP0002398_abnormal_bone_marrow0.96597582
68MP0009764_decreased_sensitivity_to0.92006683
69MP0008775_abnormal_heart_ventricle0.91816911
70MP0003195_calcinosis0.91249675
71MP0004885_abnormal_endolymph0.90258234
72MP0003172_abnormal_lysosome_physiology0.89278415
73MP0005408_hypopigmentation0.87245685
74MP0005584_abnormal_enzyme/coenzyme_acti0.85299952
75MP0002722_abnormal_immune_system0.84732923
76MP0000716_abnormal_immune_system0.84568213
77MP0008260_abnormal_autophagy0.83542409
78MP0005410_abnormal_fertilization0.83402995
79MP0002429_abnormal_blood_cell0.83116392
80MP0004947_skin_inflammation0.82106913
81MP0002876_abnormal_thyroid_physiology0.80666785
82MP0004084_abnormal_cardiac_muscle0.80461938
83MP0002736_abnormal_nociception_after0.79091984
84MP0000689_abnormal_spleen_morphology0.79082866
85MP0009840_abnormal_foam_cell0.78881933
86MP0008469_abnormal_protein_level0.78653409
87MP0003943_abnormal_hepatobiliary_system0.78284181
88MP0002277_abnormal_respiratory_mucosa0.77337976
89MP0002136_abnormal_kidney_physiology0.75762526
90MP0005551_abnormal_eye_electrophysiolog0.75511572
91MP0000920_abnormal_myelination0.75166419
92MP0009763_increased_sensitivity_to0.72292714
93MP0001529_abnormal_vocalization0.72154603
94MP0000609_abnormal_liver_physiology0.71337748
95MP0000427_abnormal_hair_cycle0.70699758
96MP0001929_abnormal_gametogenesis0.70422428
97MP0002405_respiratory_system_inflammati0.69579037
98MP0004142_abnormal_muscle_tone0.69417750
99MP0009643_abnormal_urine_homeostasis0.68990896
100MP0001348_abnormal_lacrimal_gland0.68278879

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)6.10680428
2Visual hallucinations (HP:0002367)5.88919702
3Autoimmune thrombocytopenia (HP:0001973)5.85803145
4Increased neuronal autofluorescent lipopigment (HP:0002074)4.60318202
5Poikilocytosis (HP:0004447)4.51442320
6Prostate neoplasm (HP:0100787)4.41642845
7Abnormality of the heme biosynthetic pathway (HP:0010472)4.35312888
8Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.03497146
9Increased cerebral lipofuscin (HP:0011813)3.89954076
10Tetraparesis (HP:0002273)3.31958194
11Recurrent bacterial skin infections (HP:0005406)3.26347676
12Recurrent cutaneous fungal infections (HP:0011370)2.94382952
13Chronic mucocutaneous candidiasis (HP:0002728)2.94382952
14Asplenia (HP:0001746)2.91232864
15Abnormality of T cell physiology (HP:0011840)2.73272737
16Reticulocytosis (HP:0001923)2.69610701
17Abnormality of the prostate (HP:0008775)2.68687726
18Breech presentation (HP:0001623)2.65970549
19Recurrent viral infections (HP:0004429)2.65775575
20Aplasia/Hypoplasia of the spleen (HP:0010451)2.64461044
21Acanthocytosis (HP:0001927)2.60252865
22Spastic diplegia (HP:0001264)2.53855627
23Abnormality of chloride homeostasis (HP:0011422)2.53352250
24Hypertensive crisis (HP:0100735)2.52996777
25Recurrent abscess formation (HP:0002722)2.49789762
26Testicular atrophy (HP:0000029)2.49066230
27Recurrent skin infections (HP:0001581)2.45306920
28Acute necrotizing encephalopathy (HP:0006965)2.42746854
29True hermaphroditism (HP:0010459)2.42327059
30Adrenal hypoplasia (HP:0000835)2.40877062
31Impaired platelet aggregation (HP:0003540)2.39571740
32Abnormal platelet function (HP:0011869)2.39571740
33Gingival bleeding (HP:0000225)2.38181347
34Hypochromic microcytic anemia (HP:0004840)2.36954544
35Progressive macrocephaly (HP:0004481)2.32316167
36Polycythemia (HP:0001901)2.32112167
37Menorrhagia (HP:0000132)2.29731921
38Prolonged bleeding time (HP:0003010)2.24519289
39Abnormality of pyrimidine metabolism (HP:0004353)2.24136297
40Abnormality of the gallbladder (HP:0005264)2.21499657
41Albinism (HP:0001022)2.19236996
42Pancreatic fibrosis (HP:0100732)2.16287704
43Dyschromatopsia (HP:0007641)2.15788183
44Abnormal biliary tract physiology (HP:0012439)2.10719622
45Bile duct proliferation (HP:0001408)2.10719622
46Supernumerary spleens (HP:0009799)2.10519240
47Abnormality of T cells (HP:0002843)2.09978614
48Abnormality of nucleobase metabolism (HP:0010932)2.08589348
49Abnormal gallbladder morphology (HP:0012437)2.08321294
50Cholelithiasis (HP:0001081)2.03612427
51Truncus arteriosus (HP:0001660)2.03136787
52Abnormal mitochondria in muscle tissue (HP:0008316)2.02315879
53Abnormality of purine metabolism (HP:0004352)2.01463663
54Keratoconjunctivitis (HP:0001096)2.01021701
55Central scotoma (HP:0000603)2.00891208
56Pustule (HP:0200039)1.99197823
57Systemic lupus erythematosus (HP:0002725)1.98433110
58Hyperthyroidism (HP:0000836)1.98331060
59Acute encephalopathy (HP:0006846)1.96660506
60Septate vagina (HP:0001153)1.96123385
61Progressive external ophthalmoplegia (HP:0000590)1.94990766
62Recurrent fungal infections (HP:0002841)1.90964644
63Medial flaring of the eyebrow (HP:0010747)1.89987151
64Cheilitis (HP:0100825)1.89117108
65Chronic obstructive pulmonary disease (HP:0006510)1.85752484
66Obstructive lung disease (HP:0006536)1.85752484
67Entropion (HP:0000621)1.85007061
68Thick nail (HP:0001805)1.84889086
69Cortical visual impairment (HP:0100704)1.84139817
70Epistaxis (HP:0000421)1.82937829
71Aplasia/Hypoplasia of the earlobes (HP:0009906)1.80121237
72Petechiae (HP:0000967)1.79963622
73Vasculitis (HP:0002633)1.79522879
74Nausea (HP:0002018)1.78957715
75Abnormality of chromosome stability (HP:0003220)1.76029457
76Absent speech (HP:0001344)1.75500148
77Cerebral edema (HP:0002181)1.75246903
78Esophageal neoplasm (HP:0100751)1.73658352
79Neoplasm of head and neck (HP:0012288)1.73658352
80Pancreatic cysts (HP:0001737)1.72920864
81Facial hemangioma (HP:0000329)1.72181585
82Hypokalemic alkalosis (HP:0001949)1.70446038
83Gastrointestinal infarctions (HP:0005244)1.69288877
84Sclerocornea (HP:0000647)1.68950001
85Agnosia (HP:0010524)1.66394788
86Ileus (HP:0002595)1.66255747
87Keratitis (HP:0000491)1.65046323
88Gingivitis (HP:0000230)1.64897135
89Abnormality of the peritoneum (HP:0002585)1.63567195
90Tinnitus (HP:0000360)1.63260468
91Overlapping toe (HP:0001845)1.62048095
92Cutaneous photosensitivity (HP:0000992)1.61888725
93Congenital primary aphakia (HP:0007707)1.61662150
94Microcytic anemia (HP:0001935)1.61237996
95Increased IgM level (HP:0003496)1.59435656
96Hyperbilirubinemia (HP:0002904)1.58767018
97Abnormality of the alveolar ridges (HP:0006477)1.57878539
98Methylmalonic acidemia (HP:0002912)1.57845992
99Nephrogenic diabetes insipidus (HP:0009806)1.57661171
100Abnormal glycosylation (HP:0012345)1.56976435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK6.39888454
2BMPR24.61638957
3RIPK43.46094696
4EIF2AK13.28155143
5PNCK3.01368389
6PLK42.76205353
7TXK2.25792701
8MST42.25481703
9NEK12.22066973
10TRPM72.01239490
11BRSK21.92620915
12STK41.84668651
13PIK3CG1.74032558
14TNIK1.65463140
15TRIM281.63423531
16MAP4K21.60861640
17ADRBK21.60053632
18WNK11.52517206
19MAP3K121.42518211
20MAP3K41.41580600
21MAP4K11.39522418
22WEE11.38645664
23SYK1.33273851
24PINK11.28495827
25NTRK31.26977320
26LYN1.25520237
27YES11.22735313
28PBK1.19964000
29IKBKB1.18165816
30CHEK21.14042900
31PLK21.11053101
32BRSK11.10189003
33CAMKK21.08976350
34STK31.07852276
35TEC1.06358375
36JAK31.01777458
37GRK61.00627866
38LMTK21.00215529
39FGR0.99032570
40ERBB20.97633639
41MAP3K20.96340787
42BCR0.95007268
43MAP2K30.94898285
44JAK10.93842503
45KSR10.91033618
46CSK0.89955940
47TYK20.88443636
48AKT30.86246552
49PIM10.84145201
50CLK10.83238987
51FRK0.82627646
52DYRK30.82595911
53SGK20.81566885
54CAMK1G0.80597682
55SGK10.77452764
56BTK0.74320790
57MAP3K110.73547281
58ATM0.72008539
59BUB10.67087068
60JAK20.65693888
61TAOK30.61964446
62RPS6KB10.61686443
63CAMK2D0.60323737
64MAP2K40.56556735
65WNK40.56070161
66CAMK1D0.54934770
67BMX0.52390274
68PTK2B0.51486550
69IKBKE0.49349020
70MAP2K60.47527125
71MAP3K50.46395919
72LRRK20.45861241
73AKT20.44949069
74MKNK10.44388843
75EGFR0.44296476
76CSNK2A20.43902366
77PRKCQ0.43697593
78SGK30.42286809
79MYLK0.42256672
80CSNK2A10.39404635
81NEK20.39073419
82TNK20.39060858
83HIPK20.38067028
84ADRBK10.37136841
85FES0.36988088
86MAPK120.36638017
87GRK10.35830658
88MAP3K10.34977427
89CASK0.34907956
90RPS6KA50.32695357
91GRK50.32650291
92PAK30.30683164
93PRKACB0.30551911
94NME10.30500287
95LCK0.30019370
96CHEK10.27158803
97PRKAA20.27071012
98FGFR10.26975105
99ATR0.26468856
100ERBB40.26239392

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.03765454
2Asthma_Homo sapiens_hsa053103.52187925
3Allograft rejection_Homo sapiens_hsa053303.46495299
4Autoimmune thyroid disease_Homo sapiens_hsa053203.08323375
5Graft-versus-host disease_Homo sapiens_hsa053323.02753442
6Type I diabetes mellitus_Homo sapiens_hsa049403.01002657
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.86051170
8Steroid biosynthesis_Homo sapiens_hsa001002.74848942
9Homologous recombination_Homo sapiens_hsa034402.39141602
10Leishmaniasis_Homo sapiens_hsa051402.26617972
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.21192826
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18196731
13Fanconi anemia pathway_Homo sapiens_hsa034602.04794448
14Systemic lupus erythematosus_Homo sapiens_hsa053222.00094380
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.99157005
16Rheumatoid arthritis_Homo sapiens_hsa053231.81140522
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69098767
18Antigen processing and presentation_Homo sapiens_hsa046121.67652843
19Non-homologous end-joining_Homo sapiens_hsa034501.67135233
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65761821
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63697146
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.62814860
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55516110
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.55424096
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48983279
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45616137
27Influenza A_Homo sapiens_hsa051641.43165146
28Chemokine signaling pathway_Homo sapiens_hsa040621.42251929
29Mismatch repair_Homo sapiens_hsa034301.38895180
30Phagosome_Homo sapiens_hsa041451.37827068
31Malaria_Homo sapiens_hsa051441.37677845
32Tuberculosis_Homo sapiens_hsa051521.37564686
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32746259
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27900097
35Measles_Homo sapiens_hsa051621.27629000
36Hematopoietic cell lineage_Homo sapiens_hsa046401.26565794
37Herpes simplex infection_Homo sapiens_hsa051681.24765928
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20203789
39Sphingolipid metabolism_Homo sapiens_hsa006001.19759050
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15379177
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13814545
42African trypanosomiasis_Homo sapiens_hsa051431.11684951
43Olfactory transduction_Homo sapiens_hsa047401.10025219
44Ether lipid metabolism_Homo sapiens_hsa005651.07909681
45Viral myocarditis_Homo sapiens_hsa054161.00655495
46Basal transcription factors_Homo sapiens_hsa030220.99437707
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98747455
48Spliceosome_Homo sapiens_hsa030400.97997881
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95532829
50Collecting duct acid secretion_Homo sapiens_hsa049660.88006870
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75814620
52Mineral absorption_Homo sapiens_hsa049780.74298329
53Oxidative phosphorylation_Homo sapiens_hsa001900.74085096
54Caffeine metabolism_Homo sapiens_hsa002320.73958909
55Complement and coagulation cascades_Homo sapiens_hsa046100.68802781
56Selenocompound metabolism_Homo sapiens_hsa004500.64827579
57Nucleotide excision repair_Homo sapiens_hsa034200.64253497
58One carbon pool by folate_Homo sapiens_hsa006700.64143981
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64009573
60TNF signaling pathway_Homo sapiens_hsa046680.61673714
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.58039170
62Platelet activation_Homo sapiens_hsa046110.57718051
63Osteoclast differentiation_Homo sapiens_hsa043800.55265904
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52382109
65Fatty acid biosynthesis_Homo sapiens_hsa000610.51139417
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50751831
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50101777
68Toxoplasmosis_Homo sapiens_hsa051450.49897515
69RNA degradation_Homo sapiens_hsa030180.49460708
70Pertussis_Homo sapiens_hsa051330.48284934
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.42687556
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42346839
73Propanoate metabolism_Homo sapiens_hsa006400.42165386
74B cell receptor signaling pathway_Homo sapiens_hsa046620.39634907
75Glutathione metabolism_Homo sapiens_hsa004800.39401439
76Phototransduction_Homo sapiens_hsa047440.36835488
77ABC transporters_Homo sapiens_hsa020100.35958518
78N-Glycan biosynthesis_Homo sapiens_hsa005100.34764319
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32518394
80Parkinsons disease_Homo sapiens_hsa050120.31951597
81Primary immunodeficiency_Homo sapiens_hsa053400.30648283
82Alcoholism_Homo sapiens_hsa050340.30020728
83Base excision repair_Homo sapiens_hsa034100.29517393
84Viral carcinogenesis_Homo sapiens_hsa052030.29278554
85Apoptosis_Homo sapiens_hsa042100.28489803
86Hepatitis C_Homo sapiens_hsa051600.25050933
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24947331
88Lysosome_Homo sapiens_hsa041420.24744137
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23655059
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23601973
91Hepatitis B_Homo sapiens_hsa051610.21919161
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20990551
93Alzheimers disease_Homo sapiens_hsa050100.20902312
94Prolactin signaling pathway_Homo sapiens_hsa049170.20663582
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20574011
96p53 signaling pathway_Homo sapiens_hsa041150.19328153
97Legionellosis_Homo sapiens_hsa051340.19022769
98Pyrimidine metabolism_Homo sapiens_hsa002400.18791929
99Metabolic pathways_Homo sapiens_hsa011000.17828787
100Nitrogen metabolism_Homo sapiens_hsa009100.17719040

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