CD47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.47407873
2regulation of secondary heart field cardioblast proliferation (GO:0003266)6.43013230
3regulation of cardioblast proliferation (GO:0003264)6.43013230
4outer ear morphogenesis (GO:0042473)6.04293803
5pharyngeal system development (GO:0060037)5.98174169
6positive regulation of fatty acid beta-oxidation (GO:0032000)5.68409474
7axon ensheathment in central nervous system (GO:0032291)5.36558137
8central nervous system myelination (GO:0022010)5.36558137
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.35699843
10regulation of DNA endoreduplication (GO:0032875)5.30864011
11sulfation (GO:0051923)5.28781837
12regulation of glomerulus development (GO:0090192)5.24838186
13regulation of cell proliferation involved in kidney development (GO:1901722)5.19665619
14cellular response to ATP (GO:0071318)5.17169330
15gamma-aminobutyric acid transport (GO:0015812)4.89759300
16presynaptic membrane assembly (GO:0097105)4.77599339
17cell proliferation in forebrain (GO:0021846)4.73849165
18serotonin metabolic process (GO:0042428)4.73165353
19positive regulation of fatty acid oxidation (GO:0046321)4.60979335
20cellular anion homeostasis (GO:0030002)4.58888701
21presynaptic membrane organization (GO:0097090)4.47601780
22membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.40286751
23tooth mineralization (GO:0034505)4.39960910
24long-chain fatty acid biosynthetic process (GO:0042759)4.33064642
25regulation of phospholipid biosynthetic process (GO:0071071)4.31194381
26aorta morphogenesis (GO:0035909)4.31159480
27neuron cell-cell adhesion (GO:0007158)4.30248746
28fatty acid elongation (GO:0030497)4.27876613
29positive regulation of metanephros development (GO:0072216)4.27077439
30negative regulation of neurotransmitter transport (GO:0051589)4.26312951
31primary amino compound metabolic process (GO:1901160)4.03111319
32negative regulation of appetite (GO:0032099)4.02183541
33negative regulation of response to food (GO:0032096)4.02183541
34negative regulation of systemic arterial blood pressure (GO:0003085)3.90203638
35membrane repolarization during action potential (GO:0086011)3.86731250
36negative regulation of transcription regulatory region DNA binding (GO:2000678)3.77144412
37cerebellar Purkinje cell differentiation (GO:0021702)3.64959274
38negative regulation of hormone biosynthetic process (GO:0032353)3.62109661
39positive regulation of cardiac muscle cell differentiation (GO:2000727)3.61429030
40negative regulation of neurotransmitter secretion (GO:0046929)3.60491952
41regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.60167753
42cellular response to exogenous dsRNA (GO:0071360)3.52641526
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.47604655
44membrane depolarization during action potential (GO:0086010)3.43937492
45regulation of sequestering of triglyceride (GO:0010889)3.38055813
46regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.37195720
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34849427
48dopamine transport (GO:0015872)3.34822392
49interkinetic nuclear migration (GO:0022027)3.34609639
50lung epithelial cell differentiation (GO:0060487)3.34568793
513-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.32063018
52purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.32063018
53response to UV-C (GO:0010225)3.30834946
54positive regulation of cAMP-mediated signaling (GO:0043950)3.29918732
55water-soluble vitamin biosynthetic process (GO:0042364)3.29294922
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28780930
57musculoskeletal movement (GO:0050881)3.28601752
58multicellular organismal movement (GO:0050879)3.28601752
59indole-containing compound metabolic process (GO:0042430)3.26191413
60regulation of fatty acid beta-oxidation (GO:0031998)3.21846147
61epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.21242518
62DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.20868587
63neuron remodeling (GO:0016322)3.20118254
64neuronal action potential propagation (GO:0019227)3.19704525
65regulation of organ formation (GO:0003156)3.17331205
66flavonoid metabolic process (GO:0009812)3.16462661
67ATP synthesis coupled proton transport (GO:0015986)3.15860744
68energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15860744
69lung cell differentiation (GO:0060479)3.14113852
70negative regulation of synaptic transmission, GABAergic (GO:0032229)3.11249093
71myelination (GO:0042552)3.09712760
72transmission of nerve impulse (GO:0019226)3.09686353
73negative regulation of hormone metabolic process (GO:0032351)3.08539576
74axon ensheathment (GO:0008366)3.06572464
75ensheathment of neurons (GO:0007272)3.06572464
76mast cell activation (GO:0045576)3.05633274
77positive regulation of gluconeogenesis (GO:0045722)3.04918495
78neurotransmitter uptake (GO:0001504)3.02958361
79regulation of gene silencing by RNA (GO:0060966)3.01929681
80regulation of posttranscriptional gene silencing (GO:0060147)3.01929681
81regulation of gene silencing by miRNA (GO:0060964)3.01929681
82tryptophan catabolic process (GO:0006569)3.00010853
83indole-containing compound catabolic process (GO:0042436)3.00010853
84indolalkylamine catabolic process (GO:0046218)3.00010853
85indolalkylamine metabolic process (GO:0006586)2.99802816
86chaperone-mediated protein transport (GO:0072321)2.97820079
87parturition (GO:0007567)2.96260387
88regulation of metanephros development (GO:0072215)2.95229668
89dentate gyrus development (GO:0021542)2.94380540
90negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.93151547
91negative chemotaxis (GO:0050919)2.90732488
92metanephros development (GO:0001656)2.90457464
93negative regulation of platelet activation (GO:0010544)2.90406012
94dopamine biosynthetic process (GO:0042416)2.89871531
95otic vesicle formation (GO:0030916)2.89680333
96mast cell degranulation (GO:0043303)2.87529170
97mast cell activation involved in immune response (GO:0002279)2.87529170
98regulation of dopamine metabolic process (GO:0042053)2.87139161
99regulation of catecholamine metabolic process (GO:0042069)2.87139161
100mannosylation (GO:0097502)2.86898003
101lymphoid progenitor cell differentiation (GO:0002320)2.86349748
102GPI anchor biosynthetic process (GO:0006506)2.86319523
103regulation of heart morphogenesis (GO:2000826)2.85321317
104kynurenine metabolic process (GO:0070189)2.85104430
105ionotropic glutamate receptor signaling pathway (GO:0035235)2.84405895
106middle ear morphogenesis (GO:0042474)2.83852269
107synaptic vesicle exocytosis (GO:0016079)2.83821327
108glutamate receptor signaling pathway (GO:0007215)2.83797980
109positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.81228087
110cellular response to epinephrine stimulus (GO:0071872)2.80376191
111substantia nigra development (GO:0021762)2.79437571
112protein localization to synapse (GO:0035418)2.75916891
113regulation of germinal center formation (GO:0002634)2.75654217
114respiratory electron transport chain (GO:0022904)2.74373084
115spinal cord motor neuron differentiation (GO:0021522)2.73913110
116protein sumoylation (GO:0016925)2.73416995
117regulation of glutamate secretion (GO:0014048)2.73394365
118membrane repolarization (GO:0086009)2.72695600
119amyloid precursor protein metabolic process (GO:0042982)2.72614862
120membrane assembly (GO:0071709)2.70813845
121regulation of hippo signaling (GO:0035330)2.70025524
122electron transport chain (GO:0022900)2.69452089
123vocalization behavior (GO:0071625)2.68955129
124DNA damage response, signal transduction resulting in transcription (GO:0042772)2.68041491
125fucose catabolic process (GO:0019317)2.67918028
126L-fucose metabolic process (GO:0042354)2.67918028
127L-fucose catabolic process (GO:0042355)2.67918028
128positive regulation of potassium ion transmembrane transport (GO:1901381)2.67818120
129neuron fate specification (GO:0048665)2.66690202
130catecholamine transport (GO:0051937)2.65856657
131postsynaptic membrane organization (GO:0001941)2.65704994
132cell differentiation in hindbrain (GO:0021533)2.64937934
133response to epinephrine (GO:0071871)2.63883577
134reflex (GO:0060004)2.62667635
135GPI anchor metabolic process (GO:0006505)2.60987015
136behavioral response to pain (GO:0048266)2.60490583
137phagosome maturation (GO:0090382)2.60038273
138positive regulation of synapse assembly (GO:0051965)2.60033582
139response to histamine (GO:0034776)2.59693770
140neuron-neuron synaptic transmission (GO:0007270)2.59204982
141regulation of axon regeneration (GO:0048679)2.57971860
142regulation of neuron projection regeneration (GO:0070570)2.57971860
143prostate gland growth (GO:0060736)2.56103854
144regulation of response to food (GO:0032095)2.55324682
145multicellular organismal signaling (GO:0035637)2.54946922
146regulation of collateral sprouting (GO:0048670)2.53934035
147calcium ion import (GO:0070509)2.53928951
148positive regulation of Notch signaling pathway (GO:0045747)2.52592395
149regulation of membrane repolarization (GO:0060306)2.52570095
150regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.52285497
151positive regulation of digestive system process (GO:0060456)2.51164886
152protein polyglutamylation (GO:0018095)2.50510082
153angiogenesis involved in wound healing (GO:0060055)2.50486621
154regulation of mesoderm development (GO:2000380)2.49992049
155activated T cell proliferation (GO:0050798)2.49356707
156response to methylmercury (GO:0051597)2.48529354
157neuronal action potential (GO:0019228)2.48164262
158regulation of appetite (GO:0032098)2.47592912
159protein neddylation (GO:0045116)2.47264993
160neutrophil activation involved in immune response (GO:0002283)2.47015401
161cardiovascular system development (GO:0072358)2.46984264
162glycolipid biosynthetic process (GO:0009247)2.46757767
163synaptic transmission, dopaminergic (GO:0001963)2.44834859
164developmental pigmentation (GO:0048066)2.44232051
165positive regulation of action potential (GO:0045760)2.43131642
166serotonin receptor signaling pathway (GO:0007210)2.42048027
167leukocyte degranulation (GO:0043299)2.41486636
168regulation of feeding behavior (GO:0060259)2.40051588
169leukocyte migration involved in inflammatory response (GO:0002523)2.39631263
170negative regulation of exocytosis (GO:0045920)2.39259119
171neuron recognition (GO:0008038)2.38607404
172ATP hydrolysis coupled proton transport (GO:0015991)2.38279109
173energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.38279109
174negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.37431726
175mitochondrial respiratory chain complex I assembly (GO:0032981)2.37287264
176NADH dehydrogenase complex assembly (GO:0010257)2.37287264
177mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.37287264
178adult walking behavior (GO:0007628)2.36662329
179cholesterol biosynthetic process (GO:0006695)2.36424636
180protein complex biogenesis (GO:0070271)2.34845687
181regulated secretory pathway (GO:0045055)2.34362259
182negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.33343905
183negative regulation of cell killing (GO:0031342)2.33343905
184negative regulation of synaptic transmission (GO:0050805)2.33167992
185regulation of vesicle fusion (GO:0031338)2.32465999
186oligodendrocyte differentiation (GO:0048709)2.31825829
187synaptic transmission, glutamatergic (GO:0035249)2.31084651
188intracellular pH reduction (GO:0051452)2.30635948
189regulation of excitatory postsynaptic membrane potential (GO:0060079)2.30407068
190regulation of pigment cell differentiation (GO:0050932)2.30335665
191protein localization to cilium (GO:0061512)2.29157974
192regulation of memory T cell differentiation (GO:0043380)2.28226871
193preassembly of GPI anchor in ER membrane (GO:0016254)2.27776506
194magnesium ion transport (GO:0015693)2.27261256
195cerebellar granule cell differentiation (GO:0021707)2.26457847
196positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.26272755
197glycosphingolipid biosynthetic process (GO:0006688)2.26078448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.88315960
2TAF15_26573619_Chip-Seq_HEK293_Human3.78217951
3EZH2_22144423_ChIP-Seq_EOC_Human3.61251084
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38875380
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.59534939
6* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53666807
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42787695
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39194081
9* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38534132
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34286143
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33961437
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33537804
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10160753
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07259177
15FUS_26573619_Chip-Seq_HEK293_Human2.05226509
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00669521
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00446052
18P300_19829295_ChIP-Seq_ESCs_Human1.99255215
19SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95329239
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94494794
21VDR_22108803_ChIP-Seq_LS180_Human1.92442952
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92131746
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89359350
24OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86063212
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83948011
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83410629
27ER_23166858_ChIP-Seq_MCF-7_Human1.78111500
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78107974
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73724858
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73203016
31IGF1R_20145208_ChIP-Seq_DFB_Human1.73143048
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.72936812
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70093822
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67540656
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.64853313
36AR_21572438_ChIP-Seq_LNCaP_Human1.61932750
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59962804
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58701005
39AHR_22903824_ChIP-Seq_MCF-7_Human1.58274738
40EWS_26573619_Chip-Seq_HEK293_Human1.57323333
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56906823
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56268150
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55076488
44SCL_19346495_ChIP-Seq_HPC-7_Human1.53842720
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53053325
46ZNF274_21170338_ChIP-Seq_K562_Hela1.52144500
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.51205349
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48612575
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48602241
50REST_21632747_ChIP-Seq_MESCs_Mouse1.48059644
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.48041442
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46792190
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46792190
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.45241815
55SMAD4_21799915_ChIP-Seq_A2780_Human1.44671196
56STAT3_23295773_ChIP-Seq_U87_Human1.43869066
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42864308
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42199117
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.41829370
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.38952089
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.36004591
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35870961
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35028742
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.34917188
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34853463
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31787430
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31502838
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29161707
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.28635672
70* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27418696
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25900326
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.25883934
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25820644
74* PRDM14_20953172_ChIP-Seq_ESCs_Human1.25356340
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.24950266
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24838489
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24689609
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23200936
79* TAL1_26923725_Chip-Seq_HPCs_Mouse1.22627472
80* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20714873
81RNF2_27304074_Chip-Seq_NSC_Mouse1.20371785
82P53_22387025_ChIP-Seq_ESCs_Mouse1.20320739
83* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20306703
84CBP_20019798_ChIP-Seq_JUKART_Human1.20132724
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20132724
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.18198519
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18189939
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.17558139
89AR_25329375_ChIP-Seq_VCAP_Human1.16311901
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15975776
91P300_18555785_Chip-Seq_ESCs_Mouse1.14531199
92* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13435236
93JUN_21703547_ChIP-Seq_K562_Human1.12566562
94BCAT_22108803_ChIP-Seq_LS180_Human1.12020961
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11385128
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11143436
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10864284
98IRF1_19129219_ChIP-ChIP_H3396_Human1.10099826
99TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10031138
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.09708418
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09659936
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.09307451
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.09082006
104* RUNX_20019798_ChIP-Seq_JUKART_Human1.08642360
105RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07780109
106REST_18959480_ChIP-ChIP_MESCs_Mouse1.07648562
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07160593
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.06872909
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06772888
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06772888
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.06618192
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05645363
113NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05383833
114RING1B_27294783_Chip-Seq_ESCs_Mouse1.04309823
115* KDM2B_26808549_Chip-Seq_REH_Human1.04122563
116TP53_18474530_ChIP-ChIP_U2OS_Human1.03566993
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01749123
118WT1_19549856_ChIP-ChIP_CCG9911_Human1.01730675
119SOX2_18555785_Chip-Seq_ESCs_Mouse1.01665312
120TCF4_23295773_ChIP-Seq_U87_Human1.01649978
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01099537
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99289330
123* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99091679
124TP53_16413492_ChIP-PET_HCT116_Human0.98970300
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98358238
126RUNX2_22187159_ChIP-Seq_PCA_Human0.98155239
127* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98059514
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98038134
129* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97875207
130NMYC_18555785_Chip-Seq_ESCs_Mouse0.97795922
131DROSHA_22980978_ChIP-Seq_HELA_Human0.97068871
132SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97058895
133HTT_18923047_ChIP-ChIP_STHdh_Human0.96538957
134* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95276829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.03303984
2MP0000678_abnormal_parathyroid_gland4.03651299
3MP0004134_abnormal_chest_morphology3.29481972
4MP0000920_abnormal_myelination2.91404473
5MP0001529_abnormal_vocalization2.87341512
6MP0001905_abnormal_dopamine_level2.85182580
7MP0004145_abnormal_muscle_electrophysio2.83117980
8MP0004130_abnormal_muscle_cell2.72647773
9MP0002249_abnormal_larynx_morphology2.71932396
10MP0000631_abnormal_neuroendocrine_gland2.70476291
11MP0005409_darkened_coat_color2.68218289
12MP0009745_abnormal_behavioral_response2.65583644
13MP0002064_seizures2.58822167
14MP0004859_abnormal_synaptic_plasticity2.55825188
15MP0003635_abnormal_synaptic_transmissio2.50475744
16MP0002272_abnormal_nervous_system2.50354647
17MP0001968_abnormal_touch/_nociception2.43019345
18MP0009250_abnormal_appendicular_skeleto2.42733579
19MP0009046_muscle_twitch2.38974854
20MP0000569_abnormal_digit_pigmentation2.37008383
21MP0000049_abnormal_middle_ear2.34233485
22MP0004270_analgesia2.29507842
23MP0001188_hyperpigmentation2.24208418
24MP0000681_abnormal_thyroid_gland2.17853980
25MP0003938_abnormal_ear_development2.16831105
26MP0003646_muscle_fatigue2.15883147
27MP0001501_abnormal_sleep_pattern2.12782098
28MP0003879_abnormal_hair_cell2.12265856
29MP0005423_abnormal_somatic_nervous2.11331635
30MP0002572_abnormal_emotion/affect_behav2.10518893
31MP0002160_abnormal_reproductive_system2.09645639
32MP0003195_calcinosis2.08896580
33MP0002736_abnormal_nociception_after2.08559835
34MP0002735_abnormal_chemical_nociception2.08007889
35MP0006276_abnormal_autonomic_nervous2.02612751
36MP0004142_abnormal_muscle_tone2.01768022
37MP0001486_abnormal_startle_reflex1.99314084
38MP0002063_abnormal_learning/memory/cond1.92710512
39MP0001986_abnormal_taste_sensitivity1.91863336
40MP0002734_abnormal_mechanical_nocicepti1.88439711
41MP0004147_increased_porphyrin_level1.86284330
42MP0003329_amyloid_beta_deposits1.83130693
43MP0001440_abnormal_grooming_behavior1.81896316
44MP0003724_increased_susceptibility_to1.69543756
45MP0001970_abnormal_pain_threshold1.68201524
46MP0002138_abnormal_hepatobiliary_system1.66745045
47MP0002067_abnormal_sensory_capabilities1.65082351
48MP0006292_abnormal_olfactory_placode1.62389002
49MP0003942_abnormal_urinary_system1.61445123
50MP0001177_atelectasis1.61097759
51MP0002733_abnormal_thermal_nociception1.60999254
52MP0009379_abnormal_foot_pigmentation1.60055938
53MP0000534_abnormal_ureter_morphology1.59252545
54MP0002089_abnormal_postnatal_growth/wei1.55147205
55MP0003690_abnormal_glial_cell1.53393393
56MP0004924_abnormal_behavior1.53299217
57MP0005386_behavior/neurological_phenoty1.53299217
58MP0005671_abnormal_response_to1.52150268
59MP0005389_reproductive_system_phenotype1.51633249
60MP0003638_abnormal_response/metabolism_1.49929737
61MP0005174_abnormal_tail_pigmentation1.49605423
62MP0004742_abnormal_vestibular_system1.49234012
63MP0002837_dystrophic_cardiac_calcinosis1.43415776
64MP0001853_heart_inflammation1.40994794
65MP0002148_abnormal_hypersensitivity_rea1.40340265
66MP0002822_catalepsy1.39049637
67MP0008569_lethality_at_weaning1.37160639
68MP0001835_abnormal_antigen_presentation1.37142914
69MP0000015_abnormal_ear_pigmentation1.35618875
70MP0002928_abnormal_bile_duct1.34698993
71MP0000026_abnormal_inner_ear1.33739548
72MP0008877_abnormal_DNA_methylation1.33141009
73MP0005379_endocrine/exocrine_gland_phen1.29139951
74MP0005000_abnormal_immune_tolerance1.22200861
75MP0004215_abnormal_myocardial_fiber1.21401599
76* MP0009785_altered_susceptibility_to1.20285318
77MP0000778_abnormal_nervous_system1.19813047
78MP0005645_abnormal_hypothalamus_physiol1.17953543
79MP0002229_neurodegeneration1.17901065
80MP0005171_absent_coat_pigmentation1.16856055
81MP0009780_abnormal_chondrocyte_physiolo1.16775335
82MP0002876_abnormal_thyroid_physiology1.15155935
83* MP0005025_abnormal_response_to1.11916148
84MP0001790_abnormal_immune_system1.11772862
85MP0005387_immune_system_phenotype1.11772862
86MP0000604_amyloidosis1.10784741
87MP0005075_abnormal_melanosome_morpholog1.09623341
88MP0003633_abnormal_nervous_system1.09246771
89MP0009384_cardiac_valve_regurgitation1.08545131
90MP0003136_yellow_coat_color1.06564432
91MP0004133_heterotaxia1.06312887
92MP0001765_abnormal_ion_homeostasis1.05727610
93MP0001502_abnormal_circadian_rhythm1.05150869
94MP0003631_nervous_system_phenotype1.04807362
95MP0004381_abnormal_hair_follicle1.04292312
96MP0003634_abnormal_glial_cell1.04064332
97MP0000372_irregular_coat_pigmentation1.03359210
98* MP0002419_abnormal_innate_immunity1.02789539
99MP0002066_abnormal_motor_capabilities/c1.02760093
100MP0002557_abnormal_social/conspecific_i1.02560822
101MP0005646_abnormal_pituitary_gland1.02377802
102MP0002723_abnormal_immune_serum1.02288744
103MP0003183_abnormal_peptide_metabolism1.02278860
104MP0003656_abnormal_erythrocyte_physiolo1.02179736
105MP0001984_abnormal_olfaction0.98110001
106MP0002095_abnormal_skin_pigmentation0.96890346
107MP0008874_decreased_physiological_sensi0.95637899
108* MP0002420_abnormal_adaptive_immunity0.95496679
109MP0005310_abnormal_salivary_gland0.95411876
110MP0005551_abnormal_eye_electrophysiolog0.94308072
111MP0000465_gastrointestinal_hemorrhage0.94192167
112MP0002184_abnormal_innervation0.93893190
113MP0002882_abnormal_neuron_morphology0.93593775
114MP0003787_abnormal_imprinting0.93581612
115* MP0001819_abnormal_immune_cell0.92823000
116MP0001963_abnormal_hearing_physiology0.91474274
117MP0003632_abnormal_nervous_system0.91244011
118MP0002653_abnormal_ependyma_morphology0.91104934
119MP0001800_abnormal_humoral_immune0.90588796
120MP0000685_abnormal_immune_system0.90226722
121MP0000230_abnormal_systemic_arterial0.90177484
122MP0006082_CNS_inflammation0.89715786
123MP0002396_abnormal_hematopoietic_system0.88538893
124MP0005448_abnormal_energy_balance0.87062293
125MP0001851_eye_inflammation0.86447081
126MP0005464_abnormal_platelet_physiology0.85787079
127MP0002752_abnormal_somatic_nervous0.85389208
128MP0002932_abnormal_joint_morphology0.85148674
129MP0002102_abnormal_ear_morphology0.84611544
130MP0008260_abnormal_autophagy0.84568885
131MP0001542_abnormal_bone_strength0.83566910
132MP0002277_abnormal_respiratory_mucosa0.83206163
133MP0000955_abnormal_spinal_cord0.82884276
134MP0002452_abnormal_antigen_presenting0.82809936
135MP0004885_abnormal_endolymph0.82769392
136MP0002163_abnormal_gland_morphology0.82743676
137MP0008995_early_reproductive_senescence0.82588637
138MP0008872_abnormal_physiological_respon0.81048079
139MP0002295_abnormal_pulmonary_circulatio0.80739445
140MP0003866_abnormal_defecation0.77894063
141MP0005535_abnormal_body_temperature0.77221471
142MP0001485_abnormal_pinna_reflex0.77150615
143MP0000733_abnormal_muscle_development0.76598671
144MP0003950_abnormal_plasma_membrane0.74582102
145MP0002177_abnormal_outer_ear0.74117694
146MP0003011_delayed_dark_adaptation0.73086075
147MP0004811_abnormal_neuron_physiology0.72794612
148MP0004085_abnormal_heartbeat0.72790331
149MP0000427_abnormal_hair_cycle0.72050353
150MP0002638_abnormal_pupillary_reflex0.71484546
151MP0001919_abnormal_reproductive_system0.71094756
152MP0000639_abnormal_adrenal_gland0.70285934
153MP0002282_abnormal_trachea_morphology0.70034255
154MP0002116_abnormal_craniofacial_bone0.69786522
155MP0000383_abnormal_hair_follicle0.68241024
156MP0002133_abnormal_respiratory_system0.67690106
157MP0005388_respiratory_system_phenotype0.67690106
158MP0000163_abnormal_cartilage_morphology0.67194725

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the renal collecting system (HP:0004742)6.32210804
2Genetic anticipation (HP:0003743)6.26476146
3Stenosis of the external auditory canal (HP:0000402)6.17891765
4Abnormality of cochlea (HP:0000375)5.95426692
5Lip pit (HP:0100267)5.86767035
6Morphological abnormality of the middle ear (HP:0008609)5.75851749
7Morphological abnormality of the inner ear (HP:0011390)4.68789175
8Focal motor seizures (HP:0011153)4.14288518
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.97299889
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.97299889
11Neurofibrillary tangles (HP:0002185)3.93630194
12Agitation (HP:0000713)3.80203749
13Parakeratosis (HP:0001036)3.76334227
14Down-sloping shoulders (HP:0200021)3.74796595
15Abolished electroretinogram (ERG) (HP:0000550)3.53307491
16Goiter (HP:0000853)3.53014983
17Acute necrotizing encephalopathy (HP:0006965)3.52434086
18Hypothermia (HP:0002045)3.50057371
19Mitochondrial inheritance (HP:0001427)3.47227344
20Renal Fanconi syndrome (HP:0001994)3.43986305
21Atonic seizures (HP:0010819)3.41577935
22Sensory axonal neuropathy (HP:0003390)3.29965132
23Increased hepatocellular lipid droplets (HP:0006565)3.24951072
24Decreased circulating renin level (HP:0003351)3.22240752
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.20250828
26True hermaphroditism (HP:0010459)3.20023675
27Pancreatic cysts (HP:0001737)3.19184604
28Pendular nystagmus (HP:0012043)3.19152512
29Cerebral inclusion bodies (HP:0100314)3.12941390
30Porencephaly (HP:0002132)3.12103898
31Progressive macrocephaly (HP:0004481)3.11309330
32Epileptic encephalopathy (HP:0200134)3.10211153
33Pancreatic fibrosis (HP:0100732)3.07547387
34Abnormal mitochondria in muscle tissue (HP:0008316)3.06531017
35Abnormal hair whorl (HP:0010721)3.01224861
36Absent rod-and cone-mediated responses on ERG (HP:0007688)3.00032009
37Confusion (HP:0001289)2.99075011
38Hemiplegia (HP:0002301)2.96776179
39Retinal dysplasia (HP:0007973)2.95206670
40Abnormality of the axillary hair (HP:0100134)2.94841197
41Abnormality of secondary sexual hair (HP:0009888)2.94841197
42Hepatocellular necrosis (HP:0001404)2.92529532
43Abnormality of the corticospinal tract (HP:0002492)2.92366009
44Conjunctival hamartoma (HP:0100780)2.89632144
45Abnormality of the phalanges of the 2nd finger (HP:0009541)2.86531132
46Preauricular pit (HP:0004467)2.86270914
47Periauricular skin pits (HP:0100277)2.86270914
48Hyperventilation (HP:0002883)2.82669739
49Chronic otitis media (HP:0000389)2.77342863
50Short 4th metacarpal (HP:0010044)2.77196232
51Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.77196232
52Bone cyst (HP:0012062)2.76666542
53Mixed hearing impairment (HP:0000410)2.72968072
54Increased CSF lactate (HP:0002490)2.71096913
55Nasolacrimal duct obstruction (HP:0000579)2.69583294
56Acute encephalopathy (HP:0006846)2.62858069
57Congenital sensorineural hearing impairment (HP:0008527)2.61759953
58Supranuclear gaze palsy (HP:0000605)2.60641234
59Lipid accumulation in hepatocytes (HP:0006561)2.60189277
60Focal seizures (HP:0007359)2.58589461
61Hamartoma of the eye (HP:0010568)2.58081691
62Methylmalonic acidemia (HP:0002912)2.54508469
63Broad-based gait (HP:0002136)2.53834608
64Asplenia (HP:0001746)2.51006164
65Peripheral hypomyelination (HP:0007182)2.50225151
66Progressive inability to walk (HP:0002505)2.50050800
67Febrile seizures (HP:0002373)2.48470745
68Impaired smooth pursuit (HP:0007772)2.46817427
69Furrowed tongue (HP:0000221)2.45216325
70Akinesia (HP:0002304)2.42651383
71Abnormality of the nasal septum (HP:0000419)2.41927415
72Leukodystrophy (HP:0002415)2.41299539
733-Methylglutaconic aciduria (HP:0003535)2.41220370
74Scanning speech (HP:0002168)2.40416215
75Hemiparesis (HP:0001269)2.38023023
76Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37169308
77Dialeptic seizures (HP:0011146)2.36417703
78Visual hallucinations (HP:0002367)2.36392640
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35692177
80Exertional dyspnea (HP:0002875)2.35078002
81Nephronophthisis (HP:0000090)2.34531842
82Patchy hypopigmentation of hair (HP:0011365)2.33761199
83Absence seizures (HP:0002121)2.33420406
84Abnormality of the nasolacrimal system (HP:0000614)2.32953252
85Increased corneal curvature (HP:0100692)2.32832754
86Keratoconus (HP:0000563)2.32832754
87Decreased central vision (HP:0007663)2.31480552
88Aplasia/Hypoplasia of the spleen (HP:0010451)2.30764916
89Cerebral hemorrhage (HP:0001342)2.30599561
90Increased serum pyruvate (HP:0003542)2.27899332
91Abnormality of glycolysis (HP:0004366)2.27899332
92Incomplete penetrance (HP:0003829)2.27690755
93Abnormality of ocular smooth pursuit (HP:0000617)2.27472042
94Congenital, generalized hypertrichosis (HP:0004540)2.25738792
95Increased intramyocellular lipid droplets (HP:0012240)2.25658719
96Slow saccadic eye movements (HP:0000514)2.23563570
97Metabolic alkalosis (HP:0200114)2.21896857
98Elevated erythrocyte sedimentation rate (HP:0003565)2.21098419
99Abnormal rod and cone electroretinograms (HP:0008323)2.20713062
100White forelock (HP:0002211)2.20326280
101Optic disc pallor (HP:0000543)2.19380204
102Renal dysplasia (HP:0000110)2.19236714
103Abnormality of renal resorption (HP:0011038)2.19183681
104Recurrent abscess formation (HP:0002722)2.19091921
105Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18656021
106Autoamputation (HP:0001218)2.18616759
107Severe visual impairment (HP:0001141)2.17229382
108Abnormality of the lacrimal duct (HP:0011481)2.16926701
109Cystic liver disease (HP:0006706)2.16835813
110Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.16429346
111Dysmetria (HP:0001310)2.16393664
112Spastic gait (HP:0002064)2.16041444
113Abnormality of the proximal phalanges of the hand (HP:0009834)2.13302684
114Limb dystonia (HP:0002451)2.12255657
115Short femoral neck (HP:0100864)2.09622528
116Inability to walk (HP:0002540)2.09088905
117Abnormality of the heme biosynthetic pathway (HP:0010472)2.08300250
118Truncal obesity (HP:0001956)2.07206709
119Abnormality of the 4th metacarpal (HP:0010012)2.07004619
120Papilledema (HP:0001085)2.06363246
121Diplopia (HP:0000651)2.06045871
122Abnormality of binocular vision (HP:0011514)2.06045871
123Methylmalonic aciduria (HP:0012120)2.04565369
124Gaze-evoked nystagmus (HP:0000640)2.04440145
125Abnormality of homocysteine metabolism (HP:0010919)2.04248622
126Homocystinuria (HP:0002156)2.04248622
127Abnormality of the phalanges of the 5th finger (HP:0004213)2.03026295
128Aplasia/Hypoplasia of the tibia (HP:0005772)2.02155756
129Molar tooth sign on MRI (HP:0002419)2.01621152
130Abnormality of midbrain morphology (HP:0002418)2.01621152
131Myokymia (HP:0002411)2.01017313
132Hepatic necrosis (HP:0002605)1.99917266
133Truncal ataxia (HP:0002078)1.98714460
134Skin pits (HP:0100276)1.97931304
135Abnormality of the renal medulla (HP:0100957)1.97906258
136Recurrent bacterial skin infections (HP:0005406)1.97491404
137Male pseudohermaphroditism (HP:0000037)1.97266969
138Purpura (HP:0000979)1.96962581
139Clumsiness (HP:0002312)1.96234820
140Congenital ichthyosiform erythroderma (HP:0007431)1.93715101
141Cupped ear (HP:0000378)1.93475582
142Medial flaring of the eyebrow (HP:0010747)1.93457393
143Long nose (HP:0003189)1.92051840
144Fair hair (HP:0002286)1.91316369
145Short hallux (HP:0010109)1.90473023
146Stomatitis (HP:0010280)1.89911875
147Progressive cerebellar ataxia (HP:0002073)1.89747636
148Irregular vertebral endplates (HP:0003301)1.89048175
149Action tremor (HP:0002345)1.88271500
150Type II lissencephaly (HP:0007260)1.88210528
151Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86683383
152Respiratory difficulties (HP:0002880)1.86194261
153Generalized tonic-clonic seizures (HP:0002069)1.85485974
154Abnormality of macrophages (HP:0004311)1.85001575
155Small hand (HP:0200055)1.84430997
156Restlessness (HP:0000711)1.83487903
157Meningioma (HP:0002858)1.83116310
158Neuroendocrine neoplasm (HP:0100634)1.82953571
159Absent/shortened dynein arms (HP:0200106)1.82945339
160Dynein arm defect of respiratory motile cilia (HP:0012255)1.82945339
161Gait imbalance (HP:0002141)1.81698141
162Thyroiditis (HP:0100646)1.80225186
163Abnormality of the middle phalanges of the toes (HP:0010183)1.80106988
164Congenital stationary night blindness (HP:0007642)1.79889734
165Anxiety (HP:0000739)1.79171267
166Widely spaced teeth (HP:0000687)1.78073202
167Short tibia (HP:0005736)1.77682150
168Thyroid-stimulating hormone excess (HP:0002925)1.77399487
169Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.76975600
170Chronic sinusitis (HP:0011109)1.76753317
171Abnormal pupillary function (HP:0007686)1.76363494
172Recurrent skin infections (HP:0001581)1.76345834
173Aplasia/Hypoplasia of the hallux (HP:0008362)1.76245394
174Chronic obstructive pulmonary disease (HP:0006510)1.74818584
175Obstructive lung disease (HP:0006536)1.74818584
176Chronic hepatic failure (HP:0100626)1.74622529
177Thickened helices (HP:0000391)1.73789287
178Protruding tongue (HP:0010808)1.73778977
179Abnormality of the right ventricle (HP:0001707)1.73419444
180Psychosis (HP:0000709)1.71504365
181Petechiae (HP:0000967)1.71361905
182Tinnitus (HP:0000360)1.70903457
183Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70745128
184Respiratory failure (HP:0002878)1.69670378
185Abnormal ciliary motility (HP:0012262)1.68239824
186X-linked dominant inheritance (HP:0001423)1.66792631
187Panhypogammaglobulinemia (HP:0003139)1.66724339
188Insidious onset (HP:0003587)1.66009502
189Termporal pattern (HP:0011008)1.66009502
190Polyphagia (HP:0002591)1.65732705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.14556672
2TNIK3.81591343
3GRK13.56072820
4CASK3.23835479
5MAP3K123.14458083
6CDK193.07596149
7PRKD23.02768446
8STK392.95788566
9OXSR12.76900391
10RIPK42.69995811
11PINK12.45074862
12MAPKAPK52.25765009
13MAP2K72.07365021
14TLK11.86579431
15KIT1.78252379
16INSRR1.76626868
17FES1.75901332
18STK161.74933116
19GRK71.74595935
20DAPK21.71286693
21NUAK11.71008665
22SGK21.67050215
23MST41.65004559
24BMPR1B1.60198490
25PNCK1.58909450
26ACVR1B1.56201419
27EPHA41.54053422
28ADRBK21.53347270
29MUSK1.50904358
30EPHB11.47455512
31NTRK31.43362601
32AKT31.38065045
33BMPR21.37442474
34CSNK1G31.31392009
35BCR1.29537649
36FGR1.27953896
37IRAK41.25240731
38MAP3K41.24253797
39ARAF1.22129970
40TXK1.21631882
41ERBB21.17787846
42CLK11.15911996
43PKN11.15848971
44MAP3K131.15737325
45UHMK11.15360136
46PLK21.14603532
47CAMK2B1.14393984
48NTRK11.14309549
49SYK1.13083353
50MAP3K91.12837151
51GRK51.11208063
52CSNK1G21.08883245
53NLK1.07040758
54MAPK131.06910900
55CAMKK21.05257888
56PRPF4B1.05190126
57TEC1.04799633
58TAF11.01740799
59MAP4K10.99454119
60EPHA30.98978542
61RPS6KA20.97867235
62RPS6KA60.97840750
63GRK60.97550113
64CAMK2A0.94734440
65STK110.93016122
66PRKCG0.90605339
67PAK30.88572070
68CSNK1A1L0.88322469
69MAPK150.88008660
70CAMK2D0.86795371
71MINK10.85827526
72PRKCQ0.85452956
73SGK10.84384293
74IKBKB0.82350218
75CSNK1G10.81052163
76NEK60.79851374
77PIM20.79532422
78ROCK20.79365497
79CSF1R0.79147879
80BLK0.79071037
81SGK30.79061790
82MAP3K60.78593936
83CDK50.78074224
84LCK0.75833792
85MAP3K70.75470605
86MATK0.74012844
87FGFR30.73683030
88PRKCE0.73198194
89PBK0.72572650
90BTK0.70677399
91VRK10.70164013
92TNK20.69371232
93PRKCH0.68979624
94MAP2K40.68617297
95LYN0.67443234
96MAP3K140.67272333
97CAMK40.66855577
98NME10.66690661
99IKBKE0.66556376
100SIK30.66512599
101NTRK20.66352023
102RPS6KL10.66216714
103RPS6KC10.66216714
104YES10.65812782
105WNK40.64810348
106MARK20.64261459
107MAPKAPK30.62347286
108RAF10.61882831
109ADRBK10.61698459
110DAPK10.61547218
111MARK10.61449288
112PRKD10.61040722
113HCK0.60460921
114CHUK0.59190080
115CAMKK10.58127910
116TRPM70.57318667
117SGK2230.55503538
118SGK4940.55503538
119PRKACA0.54651694
120ITK0.53993229
121CAMK2G0.53959459
122PTK2B0.53957482
123FYN0.53543274
124PIK3CA0.53360785
125RPS6KA50.53105663
126CDK30.53079041
127CSNK1A10.51472388
128MAP4K20.50429783
129PRKCZ0.49127416
130ABL10.49116288
131FGFR20.49034920
132IGF1R0.48849818
133MAPK40.47265423
134MYLK0.46990914
135TIE10.46897248
136CDK140.46695357
137DYRK20.46645675
138WNK30.46314474
139PRKG10.46027753
140PRKCA0.43288092
141DYRK1A0.42641465
142JAK10.42527853
143PDGFRB0.41645799
144MAPK70.41638036
145WNK10.41344948
146SIK20.40708114
147CCNB10.40428051
148CDK180.40357424
149CAMK10.40160688
150HIPK20.39706584
151CDK11A0.39313137
152TAOK30.39262839

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.37966950
2Nicotine addiction_Homo sapiens_hsa050332.88028508
3Parkinsons disease_Homo sapiens_hsa050122.58839013
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.44456827
5Alzheimers disease_Homo sapiens_hsa050102.41577723
6Collecting duct acid secretion_Homo sapiens_hsa049662.37027224
7Protein export_Homo sapiens_hsa030602.31354871
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19764597
9Serotonergic synapse_Homo sapiens_hsa047262.10868404
10Fatty acid elongation_Homo sapiens_hsa000622.01051001
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90491934
12Type II diabetes mellitus_Homo sapiens_hsa049301.88307080
13Morphine addiction_Homo sapiens_hsa050321.86369827
14Glutamatergic synapse_Homo sapiens_hsa047241.81528511
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.79384494
16GABAergic synapse_Homo sapiens_hsa047271.75251742
17Melanoma_Homo sapiens_hsa052181.72089061
18Steroid biosynthesis_Homo sapiens_hsa001001.71124915
19Synaptic vesicle cycle_Homo sapiens_hsa047211.68258649
20Rheumatoid arthritis_Homo sapiens_hsa053231.65022916
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63164971
22Ether lipid metabolism_Homo sapiens_hsa005651.57630924
23Taste transduction_Homo sapiens_hsa047421.53689365
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52099850
25Huntingtons disease_Homo sapiens_hsa050161.51447988
26Long-term depression_Homo sapiens_hsa047301.50315594
27Vitamin digestion and absorption_Homo sapiens_hsa049771.48527193
28Long-term potentiation_Homo sapiens_hsa047201.47031545
29Vibrio cholerae infection_Homo sapiens_hsa051101.46811127
30Circadian entrainment_Homo sapiens_hsa047131.45568446
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44336180
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.41951640
33Dorso-ventral axis formation_Homo sapiens_hsa043201.38384411
34Amphetamine addiction_Homo sapiens_hsa050311.36643795
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35680017
36Dopaminergic synapse_Homo sapiens_hsa047281.31390433
37Renin secretion_Homo sapiens_hsa049241.30633633
38Salivary secretion_Homo sapiens_hsa049701.28503277
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24514136
40Sphingolipid metabolism_Homo sapiens_hsa006001.22097172
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18778512
42MAPK signaling pathway_Homo sapiens_hsa040101.17951812
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16217680
44Cocaine addiction_Homo sapiens_hsa050301.14423860
45Linoleic acid metabolism_Homo sapiens_hsa005911.12746977
46African trypanosomiasis_Homo sapiens_hsa051431.11807097
47Olfactory transduction_Homo sapiens_hsa047401.10161648
48Allograft rejection_Homo sapiens_hsa053301.09949772
49Primary immunodeficiency_Homo sapiens_hsa053401.09888678
50Nitrogen metabolism_Homo sapiens_hsa009101.09554446
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08155715
52Phagosome_Homo sapiens_hsa041451.04803599
53Calcium signaling pathway_Homo sapiens_hsa040201.03505306
54Cholinergic synapse_Homo sapiens_hsa047251.02462498
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02374979
56Cardiac muscle contraction_Homo sapiens_hsa042601.00146538
57Graft-versus-host disease_Homo sapiens_hsa053320.99583877
58Tryptophan metabolism_Homo sapiens_hsa003800.99500127
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98979608
60Phototransduction_Homo sapiens_hsa047440.98357436
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96698847
62Autoimmune thyroid disease_Homo sapiens_hsa053200.95906528
63Chemical carcinogenesis_Homo sapiens_hsa052040.95294002
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90548600
65Glycerolipid metabolism_Homo sapiens_hsa005610.89443623
66Hematopoietic cell lineage_Homo sapiens_hsa046400.88520847
67Ribosome_Homo sapiens_hsa030100.88302758
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87541121
69Axon guidance_Homo sapiens_hsa043600.85036404
70Gastric acid secretion_Homo sapiens_hsa049710.84119658
71Rap1 signaling pathway_Homo sapiens_hsa040150.83122705
72Asthma_Homo sapiens_hsa053100.81600098
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78972744
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.78945539
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77502185
76Retinol metabolism_Homo sapiens_hsa008300.75703346
77Homologous recombination_Homo sapiens_hsa034400.75324558
78Renin-angiotensin system_Homo sapiens_hsa046140.74523726
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.73613734
80Oxytocin signaling pathway_Homo sapiens_hsa049210.73599456
81ABC transporters_Homo sapiens_hsa020100.73507523
82B cell receptor signaling pathway_Homo sapiens_hsa046620.72828180
83Malaria_Homo sapiens_hsa051440.71168884
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71166561
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70430818
86Pertussis_Homo sapiens_hsa051330.70273891
87Type I diabetes mellitus_Homo sapiens_hsa049400.67736144
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66379989
89Staphylococcus aureus infection_Homo sapiens_hsa051500.66232293
90Hedgehog signaling pathway_Homo sapiens_hsa043400.65110367
91Proteasome_Homo sapiens_hsa030500.63663536
92Basal cell carcinoma_Homo sapiens_hsa052170.63285038
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63177258
94Chemokine signaling pathway_Homo sapiens_hsa040620.62196994
95T cell receptor signaling pathway_Homo sapiens_hsa046600.61306725
96Ovarian steroidogenesis_Homo sapiens_hsa049130.61035170
97Glioma_Homo sapiens_hsa052140.60617413
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59732720
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.59569341
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.59484901
101cAMP signaling pathway_Homo sapiens_hsa040240.59298758
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59108039
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.57998268
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57478033
105Sulfur metabolism_Homo sapiens_hsa009200.57130403
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57032483
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56991564
108Pancreatic secretion_Homo sapiens_hsa049720.55553698
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55495096
110Platelet activation_Homo sapiens_hsa046110.53882698
111Systemic lupus erythematosus_Homo sapiens_hsa053220.53043830
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52670681
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51729850
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.51482120
115Tuberculosis_Homo sapiens_hsa051520.51479109
116Insulin resistance_Homo sapiens_hsa049310.50801562
117Leishmaniasis_Homo sapiens_hsa051400.50578929
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50305734
119Choline metabolism in cancer_Homo sapiens_hsa052310.50133008
120Dilated cardiomyopathy_Homo sapiens_hsa054140.48803051
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48737783
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47860326
123Insulin secretion_Homo sapiens_hsa049110.47226965
124Salmonella infection_Homo sapiens_hsa051320.47172923
125Histidine metabolism_Homo sapiens_hsa003400.46958141
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46460862
127Non-homologous end-joining_Homo sapiens_hsa034500.46307145
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45321318
129GnRH signaling pathway_Homo sapiens_hsa049120.44874048
130Gap junction_Homo sapiens_hsa045400.44734940
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43778465
132Alcoholism_Homo sapiens_hsa050340.42803569
133Ras signaling pathway_Homo sapiens_hsa040140.42233621
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41559516
135Circadian rhythm_Homo sapiens_hsa047100.41227451
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39620477
137Shigellosis_Homo sapiens_hsa051310.39543067
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.39255791
139Caffeine metabolism_Homo sapiens_hsa002320.39209310
140Osteoclast differentiation_Homo sapiens_hsa043800.38636009
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37963235
142MicroRNAs in cancer_Homo sapiens_hsa052060.35799521
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33309084

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