CD52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.91300741
2antigen processing and presentation of endogenous antigen (GO:0019883)6.52731453
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.49830138
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.49830138
5positive regulation of gamma-delta T cell activation (GO:0046645)5.29722839
6cytidine deamination (GO:0009972)5.17011690
7cytidine metabolic process (GO:0046087)5.17011690
8cytidine catabolic process (GO:0006216)5.17011690
9regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.08159535
10leukocyte aggregation (GO:0070486)4.86668763
11pyrimidine ribonucleoside catabolic process (GO:0046133)4.73025770
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.72686635
13neutrophil activation involved in immune response (GO:0002283)4.66110415
14antigen processing and presentation via MHC class Ib (GO:0002475)4.65276728
15DNA deamination (GO:0045006)4.59249983
16regulation of B cell receptor signaling pathway (GO:0050855)4.57094461
17immunoglobulin mediated immune response (GO:0016064)4.44859120
18T cell migration (GO:0072678)4.36562399
19positive regulation of antigen processing and presentation (GO:0002579)4.28891862
20negative thymic T cell selection (GO:0045060)4.28225596
21actin nucleation (GO:0045010)4.22969762
22negative T cell selection (GO:0043383)4.21283598
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.20843795
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.18497529
25regulation of natural killer cell mediated immunity (GO:0002715)4.10590130
26regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.10590130
27positive regulation of interferon-alpha production (GO:0032727)4.05796889
28type I interferon signaling pathway (GO:0060337)3.98546967
29cellular response to type I interferon (GO:0071357)3.98546967
30cellular response to zinc ion (GO:0071294)3.98427993
31sequestering of actin monomers (GO:0042989)3.98419771
32response to type I interferon (GO:0034340)3.97360361
33positive thymic T cell selection (GO:0045059)3.96706014
34positive regulation of natural killer cell mediated immunity (GO:0002717)3.89360832
35regulation of interferon-alpha production (GO:0032647)3.85914523
36T cell receptor signaling pathway (GO:0050852)3.85465333
37positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.85112162
38positive regulation of T cell mediated cytotoxicity (GO:0001916)3.81928142
39positive regulation of alpha-beta T cell proliferation (GO:0046641)3.78268728
40regulation of T cell mediated cytotoxicity (GO:0001914)3.78129858
41regulation of leukocyte mediated cytotoxicity (GO:0001910)3.77342769
42regulation of antigen processing and presentation (GO:0002577)3.75983354
43positive regulation by symbiont of host defense response (GO:0052509)3.75924822
44modulation by symbiont of host defense response (GO:0052031)3.75924822
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.75924822
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.75924822
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.75924822
48modulation by symbiont of host immune response (GO:0052553)3.75924822
49regulation of regulatory T cell differentiation (GO:0045589)3.73773406
50regulation of alpha-beta T cell proliferation (GO:0046640)3.72203190
51Arp2/3 complex-mediated actin nucleation (GO:0034314)3.70825474
52cellular response to interferon-beta (GO:0035458)3.70750254
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69399311
54negative regulation of cell killing (GO:0031342)3.69399311
55interferon-gamma-mediated signaling pathway (GO:0060333)3.67220756
56regulation of gamma-delta T cell differentiation (GO:0045586)3.65497119
57response to peptidoglycan (GO:0032494)3.64193273
58positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.62630948
59granulocyte activation (GO:0036230)3.62563571
60regulation of gamma-delta T cell activation (GO:0046643)3.59743793
61neutrophil activation (GO:0042119)3.59340004
62B cell mediated immunity (GO:0019724)3.58733782
63defense response to protozoan (GO:0042832)3.54802445
64negative regulation of T cell apoptotic process (GO:0070233)3.54030055
65positive regulation of tolerance induction (GO:0002645)3.52669083
66regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.51256135
67positive regulation of cell killing (GO:0031343)3.50701325
68positive regulation of calcium-mediated signaling (GO:0050850)3.50456676
69regulation of B cell differentiation (GO:0045577)3.49992283
70regulation of tolerance induction (GO:0002643)3.48692660
71regulation of cell killing (GO:0031341)3.47089412
72* respiratory burst (GO:0045730)3.46346278
73B cell receptor signaling pathway (GO:0050853)3.45559469
74interferon-gamma production (GO:0032609)3.45528160
75cellular response to exogenous dsRNA (GO:0071360)3.43798416
76thymic T cell selection (GO:0045061)3.42940714
77mast cell activation (GO:0045576)3.37141389
78regulation of interferon-beta biosynthetic process (GO:0045357)3.33204410
79regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.31124071
80cellular response to interleukin-15 (GO:0071350)3.29987067
81natural killer cell mediated immunity (GO:0002228)3.29909768
82natural killer cell mediated cytotoxicity (GO:0042267)3.29909768
83regulation of isotype switching to IgG isotypes (GO:0048302)3.28793467
84myeloid dendritic cell activation (GO:0001773)3.27382073
85regulation of activation of Janus kinase activity (GO:0010533)3.25664804
86T cell costimulation (GO:0031295)3.24404554
87lymphocyte migration (GO:0072676)3.23832335
88response to interleukin-15 (GO:0070672)3.21696956
89lymphocyte costimulation (GO:0031294)3.20621138
90response to protozoan (GO:0001562)3.19853448
91positive regulation of B cell mediated immunity (GO:0002714)3.19295829
92positive regulation of immunoglobulin mediated immune response (GO:0002891)3.19295829
93T cell selection (GO:0045058)3.18385172
94lipopolysaccharide-mediated signaling pathway (GO:0031663)3.17207641
95natural killer cell activation (GO:0030101)3.16466096
96positive regulation of interleukin-2 production (GO:0032743)3.16279717
97myeloid dendritic cell differentiation (GO:0043011)3.16134375
98myeloid cell activation involved in immune response (GO:0002275)3.15411536
99regulation of interleukin-12 biosynthetic process (GO:0045075)3.15063186
100response to interferon-beta (GO:0035456)3.13946084
101regulation of T cell tolerance induction (GO:0002664)3.13341289
102positive T cell selection (GO:0043368)3.12884158
103hydrogen peroxide biosynthetic process (GO:0050665)3.12123923
104leukocyte cell-cell adhesion (GO:0007159)3.10260505
105activated T cell proliferation (GO:0050798)3.10065679
106positive regulation of isotype switching (GO:0045830)3.09141956
107positive regulation of mast cell activation (GO:0033005)3.09127600
108negative regulation of viral genome replication (GO:0045071)3.08547259
109negative regulation of lymphocyte mediated immunity (GO:0002707)3.07327335
110positive regulation of interleukin-4 production (GO:0032753)3.07078454
111negative regulation of leukocyte mediated immunity (GO:0002704)3.06268978
112positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.05860803
113regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.04393626
114cellular extravasation (GO:0045123)3.03962277
115dendritic cell chemotaxis (GO:0002407)3.02629199
116lymphocyte chemotaxis (GO:0048247)3.02483793
117detection of bacterium (GO:0016045)3.00253489
118positive regulation of chemokine biosynthetic process (GO:0045080)2.99757522
119macrophage activation involved in immune response (GO:0002281)2.99074124
120negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.98640538
121regulation of interleukin-2 biosynthetic process (GO:0045076)2.98178597
122regulation of T cell receptor signaling pathway (GO:0050856)2.97204320
123positive regulation of interleukin-12 production (GO:0032735)2.96301326
124cellular defense response (GO:0006968)2.95471549
125positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.94708690
126regulation of type I interferon-mediated signaling pathway (GO:0060338)2.94346472
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.93044955
128negative regulation of T cell mediated immunity (GO:0002710)2.92777874
129positive regulation of granulocyte differentiation (GO:0030854)2.92715378
130positive regulation of interferon-beta production (GO:0032728)2.91675565
131positive regulation of lymphocyte mediated immunity (GO:0002708)2.91655010
132superoxide anion generation (GO:0042554)2.90501657
133NIK/NF-kappaB signaling (GO:0038061)2.90244286
134detection of other organism (GO:0098543)2.90101775
135tolerance induction (GO:0002507)2.90095315
136positive regulation of T cell mediated immunity (GO:0002711)2.90036865
137positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.89922280
138antigen receptor-mediated signaling pathway (GO:0050851)2.88759125
139positive regulation of defense response to virus by host (GO:0002230)2.88592434
140positive regulation of interferon-gamma production (GO:0032729)2.88400913
141regulation of T-helper 1 cell differentiation (GO:0045625)2.86961837
142leukocyte degranulation (GO:0043299)2.86688882
143positive regulation of B cell differentiation (GO:0045579)2.86063322
144Peyers patch development (GO:0048541)2.86023502
145mucosal-associated lymphoid tissue development (GO:0048537)2.86023502
146cellular response to interferon-gamma (GO:0071346)2.84289999

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.14445760
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.33157483
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.52729959
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.93843646
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.91710293
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.31656543
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.23300618
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.67264288
9* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.44378591
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44244728
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.27615733
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.27506124
13* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.24075043
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09352937
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55903466
16MYB_26560356_Chip-Seq_TH2_Human2.55235455
17RUNX_20019798_ChIP-Seq_JUKART_Human2.45304379
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40795615
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.40120431
20* SPI1_23547873_ChIP-Seq_NB4_Human2.32100816
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.31532704
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25957002
23* MAF_26560356_Chip-Seq_TH1_Human2.22755303
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.19196022
25MYB_26560356_Chip-Seq_TH1_Human2.06130725
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02725011
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00389356
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99748712
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.89455392
30* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87559903
31UTX_26944678_Chip-Seq_JUKART_Human1.82237298
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77576151
33VDR_24763502_ChIP-Seq_THP-1_Human1.72613417
34MYC_22102868_ChIP-Seq_BL_Human1.70291867
35GATA1_22025678_ChIP-Seq_K562_Human1.68255426
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.68184225
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65135100
38CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64663229
39* GATA3_27048872_Chip-Seq_THYMUS_Human1.61794781
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61256015
41VDR_21846776_ChIP-Seq_THP-1_Human1.60874357
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59320819
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58434738
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57767232
45PU_27001747_Chip-Seq_BMDM_Mouse1.56828949
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54220625
47SPI1_23127762_ChIP-Seq_K562_Human1.53641057
48CIITA_25753668_ChIP-Seq_RAJI_Human1.48013395
49CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.46152987
50SCL_19346495_ChIP-Seq_HPC-7_Human1.41998564
51CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37115693
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36453797
53* MAF_26560356_Chip-Seq_TH2_Human1.35816336
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34768289
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31492073
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29930660
57* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28390720
58* GATA3_26560356_Chip-Seq_TH2_Human1.27797328
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25029483
60E2F7_22180533_ChIP-Seq_HELA_Human1.24045360
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21924939
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20278855
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19514192
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18404036
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16225398
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15491631
67VDR_24787735_ChIP-Seq_THP-1_Human1.14122909
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.13567455
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13424599
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13219383
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12020758
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.11630682
73BCOR_27268052_Chip-Seq_Bcells_Human1.09099733
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07363114
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07195179
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04961528
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04330550
78RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04185582
79TCF7_22412390_ChIP-Seq_EML_Mouse1.00669843
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00384606
81HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97752384
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96610770
83NOTCH1_21737748_ChIP-Seq_TLL_Human0.95124746
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94502508
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93724837
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93094138
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91904630
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90057735
89FOXP3_21729870_ChIP-Seq_TREG_Human0.89686456
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89620782
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88052766
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87857675
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85482197
94EGR1_19032775_ChIP-ChIP_M12_Human0.82374520
95STAT1_20625510_ChIP-Seq_HELA_Human0.81132931
96GATA3_26560356_Chip-Seq_TH1_Human0.81006300
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.80387405
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78118301
99GATA1_19941826_ChIP-Seq_K562_Human0.77373335
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75829042
101E2F1_20622854_ChIP-Seq_HELA_Human0.74659406
102YY1_22570637_ChIP-Seq_MALME-3M_Human0.74615699
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72657982
104NANOG_20526341_ChIP-Seq_ESCs_Human0.72627280
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72504938
106KDM2B_26808549_Chip-Seq_DND41_Human0.72022918
107* SA1_27219007_Chip-Seq_Bcells_Human0.70815911
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68802037
109SPI1_20517297_ChIP-Seq_HL60_Human0.67884197
110GATA1_19941827_ChIP-Seq_MEL_Mouse0.67486181
111EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.65382724
112* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64942790
113ELK1_19687146_ChIP-ChIP_HELA_Human0.63692963
114P300_27268052_Chip-Seq_Bcells_Human0.62909651
115* CTCF_26484167_Chip-Seq_Bcells_Mouse0.62813238
116BCL6_27268052_Chip-Seq_Bcells_Human0.61532025
117TFEB_21752829_ChIP-Seq_HELA_Human0.60668675
118SMRT_27268052_Chip-Seq_Bcells_Human0.59431479
119VDR_23849224_ChIP-Seq_CD4+_Human0.58779431
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.57983567
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.56948083
122RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.56169665
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.55831605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.46435199
2MP0005671_abnormal_response_to4.11348927
3MP0009785_altered_susceptibility_to3.87821652
4MP0003436_decreased_susceptibility_to3.57958083
5MP0005000_abnormal_immune_tolerance3.49160639
6MP0000685_abnormal_immune_system3.48170823
7MP0002148_abnormal_hypersensitivity_rea3.45363631
8MP0006082_CNS_inflammation3.42763190
9MP0001790_abnormal_immune_system3.29703815
10MP0005387_immune_system_phenotype3.29703815
11MP0001800_abnormal_humoral_immune3.21557815
12MP0005025_abnormal_response_to3.19975730
13MP0002452_abnormal_antigen_presenting3.03100899
14MP0003303_peritoneal_inflammation2.94943763
15MP0002419_abnormal_innate_immunity2.94072931
16MP0002723_abnormal_immune_serum2.93925153
17MP0001819_abnormal_immune_cell2.78894755
18MP0002420_abnormal_adaptive_immunity2.77848344
19MP0003763_abnormal_thymus_physiology2.67072120
20MP0003724_increased_susceptibility_to2.62418227
21MP0002006_tumorigenesis2.47196517
22MP0002166_altered_tumor_susceptibility2.42430110
23MP0002405_respiratory_system_inflammati2.26184926
24MP0004510_myositis2.22497922
25MP0002398_abnormal_bone_marrow2.19647131
26MP0000716_abnormal_immune_system2.14860938
27MP0001853_heart_inflammation2.09736437
28MP0009333_abnormal_splenocyte_physiolog2.07423573
29MP0001845_abnormal_inflammatory_respons2.00031487
30MP0004947_skin_inflammation1.96792760
31MP0010155_abnormal_intestine_physiology1.96540887
32MP0005464_abnormal_platelet_physiology1.91816337
33MP0005310_abnormal_salivary_gland1.86741559
34MP0005058_abnormal_lysosome_morphology1.82735182
35MP0000689_abnormal_spleen_morphology1.74366009
36MP0001533_abnormal_skeleton_physiology1.74279342
37MP0002429_abnormal_blood_cell1.71539097
38MP0002722_abnormal_immune_system1.68315016
39MP0003448_altered_tumor_morphology1.65094448
40MP0009764_decreased_sensitivity_to1.60526522
41MP0000858_altered_metastatic_potential1.59690830
42MP0008469_abnormal_protein_level1.59316972
43MP0002933_joint_inflammation1.43993788
44MP0005075_abnormal_melanosome_morpholog1.40999319
45MP0001873_stomach_inflammation1.34110344
46MP0003300_gastrointestinal_ulcer1.33358600
47MP0003866_abnormal_defecation1.32446872
48MP0002998_abnormal_bone_remodeling1.24404010
49MP0000703_abnormal_thymus_morphology1.23631554
50MP0000343_altered_response_to1.21009905
51MP0005166_decreased_susceptibility_to1.14490235
52MP0005645_abnormal_hypothalamus_physiol1.03317596
53MP0003075_altered_response_to1.00416827
54MP0002138_abnormal_hepatobiliary_system0.99910016
55MP0009763_increased_sensitivity_to0.98131594
56MP0003172_abnormal_lysosome_physiology0.97410181
57MP0001545_abnormal_hematopoietic_system0.95319113
58MP0005397_hematopoietic_system_phenotyp0.95319113
59MP0003806_abnormal_nucleotide_metabolis0.92643341
60MP0001851_eye_inflammation0.91015652
61MP0003191_abnormal_cellular_cholesterol0.85303854
62MP0002396_abnormal_hematopoietic_system0.84724287
63MP0003186_abnormal_redox_activity0.81329318
64MP0003183_abnormal_peptide_metabolism0.81047721
65MP0003045_fibrosis0.80291815
66MP0000490_abnormal_crypts_of0.78250920
67MP0010352_gastrointestinal_tract_polyps0.76592407
68MP0004808_abnormal_hematopoietic_stem0.75256309
69MP0002019_abnormal_tumor_incidence0.74813915
70MP0002136_abnormal_kidney_physiology0.73762695
71MP0005174_abnormal_tail_pigmentation0.71819565
72MP0005390_skeleton_phenotype0.70227656
73MP0003646_muscle_fatigue0.70050028
74MP0004782_abnormal_surfactant_physiolog0.69782820
75MP0004883_abnormal_blood_vessel0.68361620
76MP0009278_abnormal_bone_marrow0.68096811
77MP0001986_abnormal_taste_sensitivity0.67806249
78MP0000604_amyloidosis0.66184282
79MP0003828_pulmonary_edema0.65126790
80MP0001663_abnormal_digestive_system0.62670412
81MP0003795_abnormal_bone_structure0.62452748
82MP0005076_abnormal_cell_differentiation0.62106251
83MP0002693_abnormal_pancreas_physiology0.60916209
84MP0000249_abnormal_blood_vessel0.60032328
85MP0003453_abnormal_keratinocyte_physiol0.59625921
86MP0000465_gastrointestinal_hemorrhage0.58604590
87MP0000015_abnormal_ear_pigmentation0.55897892
88MP0001765_abnormal_ion_homeostasis0.55781649
89MP0009643_abnormal_urine_homeostasis0.55320916
90MP0005164_abnormal_response_to0.54083261
91MP0009765_abnormal_xenobiotic_induced0.53560255
92MP0008872_abnormal_physiological_respon0.52673367
93MP0009840_abnormal_foam_cell0.52239181
94MP0005377_hearing/vestibular/ear_phenot0.52004306
95MP0003878_abnormal_ear_physiology0.52004306
96MP0001919_abnormal_reproductive_system0.51982339
97MP0002132_abnormal_respiratory_system0.51582055
98MP0001348_abnormal_lacrimal_gland0.50125220
99MP0010307_abnormal_tumor_latency0.49594893
100MP0003786_premature_aging0.49243708
101MP0000371_diluted_coat_color0.49136726
102MP0002277_abnormal_respiratory_mucosa0.48337818
103MP0002254_reproductive_system_inflammat0.48316036
104MP0003252_abnormal_bile_duct0.47904936
105MP0002009_preneoplasia0.47686121
106MP0000372_irregular_coat_pigmentation0.47391601
107MP0003690_abnormal_glial_cell0.44962735
108MP0001191_abnormal_skin_condition0.44660042
109MP0005023_abnormal_wound_healing0.44154551
110MP0008873_increased_physiological_sensi0.43614176
111MP0008874_decreased_physiological_sensi0.43375916
112MP0001881_abnormal_mammary_gland0.42755719
113MP0005319_abnormal_enzyme/_coenzyme0.42715734
114MP0002095_abnormal_skin_pigmentation0.42598015
115MP0000920_abnormal_myelination0.42050991
116MP0008260_abnormal_autophagy0.41983935
117MP0010386_abnormal_urinary_bladder0.41671532
118MP0003656_abnormal_erythrocyte_physiolo0.41425230
119MP0000609_abnormal_liver_physiology0.41387645
120MP0005451_abnormal_body_composition0.41352382
121MP0004381_abnormal_hair_follicle0.39256503

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.12595512
2Recurrent abscess formation (HP:0002722)6.66091706
3Recurrent bacterial skin infections (HP:0005406)5.90616833
4Recurrent gram-negative bacterial infections (HP:0005420)5.86815667
5Elevated erythrocyte sedimentation rate (HP:0003565)5.37784498
6Recurrent fungal infections (HP:0002841)4.71841126
7Mediastinal lymphadenopathy (HP:0100721)4.61752920
8Stomatitis (HP:0010280)4.51504640
9Increased IgM level (HP:0003496)4.43499364
10Abnormality of macrophages (HP:0004311)4.41709843
11Recurrent skin infections (HP:0001581)4.35616483
12Myositis (HP:0100614)4.35415320
13Chronic mucocutaneous candidiasis (HP:0002728)4.32441016
14Recurrent cutaneous fungal infections (HP:0011370)4.32441016
15Recurrent bronchitis (HP:0002837)4.16253345
16Abnormality of T cell number (HP:0011839)4.14513981
17Chronic obstructive pulmonary disease (HP:0006510)4.09733055
18Obstructive lung disease (HP:0006536)4.09733055
19Recurrent viral infections (HP:0004429)4.06592493
20T lymphocytopenia (HP:0005403)3.97791310
21Vasculitis (HP:0002633)3.91792189
22Autoimmune thrombocytopenia (HP:0001973)3.88615909
23Gingivitis (HP:0000230)3.84445328
24Vacuolated lymphocytes (HP:0001922)3.83010014
25Aplastic anemia (HP:0001915)3.82275297
26Agammaglobulinemia (HP:0004432)3.66579845
27Meningitis (HP:0001287)3.65938244
28Optic neuritis (HP:0100653)3.52673110
29Retrobulbar optic neuritis (HP:0100654)3.52673110
30Orchitis (HP:0100796)3.50002637
31Cellulitis (HP:0100658)3.49135517
32Chronic otitis media (HP:0000389)3.48087766
33IgM deficiency (HP:0002850)3.47466997
34Abnormality of T cells (HP:0002843)3.46983372
35IgG deficiency (HP:0004315)3.39144416
36Pustule (HP:0200039)3.26888810
37Lymphopenia (HP:0001888)3.26661627
38Abnormality of cells of the lymphoid lineage (HP:0012140)3.22085070
39Combined immunodeficiency (HP:0005387)3.19822464
40Severe combined immunodeficiency (HP:0004430)3.14772214
41Recurrent sinusitis (HP:0011108)3.13627022
42Recurrent pneumonia (HP:0006532)3.12076886
43Hypergammaglobulinemia (HP:0010702)3.11200207
44Gastrointestinal stroma tumor (HP:0100723)3.10270784
45Autoimmune hemolytic anemia (HP:0001890)3.05081480
46Basal ganglia calcification (HP:0002135)3.01009326
47Hypoproteinemia (HP:0003075)2.99428802
48Abnormality of T cell physiology (HP:0011840)2.93881974
49Interstitial pulmonary disease (HP:0006530)2.92648122
50Pulmonary infiltrates (HP:0002113)2.88000687
51Hemoptysis (HP:0002105)2.86649493
52Leukocytosis (HP:0001974)2.86025038
53Nasal polyposis (HP:0100582)2.85297897
54Recurrent lower respiratory tract infections (HP:0002783)2.80969679
55Thyroiditis (HP:0100646)2.78211271
56IgA deficiency (HP:0002720)2.76848268
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.73112984
58Urticaria (HP:0001025)2.72531658
59Gastrointestinal infarctions (HP:0005244)2.67377672
60Panhypogammaglobulinemia (HP:0003139)2.65370232
61Chronic diarrhea (HP:0002028)2.61186605
62Periodontitis (HP:0000704)2.60298187
63Inflammation of the large intestine (HP:0002037)2.59324882
64Osteomyelitis (HP:0002754)2.58801258
65Chest pain (HP:0100749)2.57945818
66Systemic lupus erythematosus (HP:0002725)2.57299082
67Colitis (HP:0002583)2.56362228
68Abnormality of eosinophils (HP:0001879)2.53383120
69Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.52213271
70Abnormality of the nasal mucosa (HP:0000433)2.49554420
71Eosinophilia (HP:0001880)2.47242127
72Gastrointestinal inflammation (HP:0004386)2.45178538
73Joint swelling (HP:0001386)2.43384470
74Emphysema (HP:0002097)2.42784859
75Increased IgE level (HP:0003212)2.40674268
76Cheilitis (HP:0100825)2.38118725
77Petechiae (HP:0000967)2.36405727
78Keratoconjunctivitis sicca (HP:0001097)2.36229058
79Verrucae (HP:0200043)2.34664883
80Papilloma (HP:0012740)2.34664883
81B lymphocytopenia (HP:0010976)2.34627802
82Abnormality of B cell number (HP:0010975)2.34627802
83Prostate neoplasm (HP:0100787)2.33565479
84Arterial thrombosis (HP:0004420)2.33215904
85Sepsis (HP:0100806)2.31873637
86Gangrene (HP:0100758)2.30004841
87Increased cerebral lipofuscin (HP:0011813)2.28200224
88Increased neuronal autofluorescent lipopigment (HP:0002074)2.27591282
89Encephalitis (HP:0002383)2.27287410
90Bronchitis (HP:0012387)2.26281885
91Thrombocytosis (HP:0001894)2.23392816
92Chronic sinusitis (HP:0011109)2.22206644
93Keratoconjunctivitis (HP:0001096)2.20960798
94Skin ulcer (HP:0200042)2.20274246
95Pulmonary embolism (HP:0002204)2.20177142
96Acute hepatic failure (HP:0006554)2.19397063
97Spontaneous hematomas (HP:0007420)2.18900211
98Abnormality of the pleura (HP:0002103)2.18249250
99Granulocytopenia (HP:0001913)2.17715828
100Gingival bleeding (HP:0000225)2.17692987
101Pulmonary fibrosis (HP:0002206)2.17529965
102Hypoplasia of the thymus (HP:0000778)2.13198377
103Recurrent otitis media (HP:0000403)2.12924044
104Epistaxis (HP:0000421)2.10690887
105Arthralgia (HP:0002829)2.10382937
106Restrictive lung disease (HP:0002091)2.08589619
107Abnormality of glycosphingolipid metabolism (HP:0004343)2.08575891
108Abnormality of glycolipid metabolism (HP:0010969)2.08575891
109Abnormality of liposaccharide metabolism (HP:0010968)2.08575891
110Disinhibition (HP:0000734)2.06410197
111Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05414216
112Dysostosis multiplex (HP:0000943)2.04023076
113Lymphoma (HP:0002665)2.03008667
114Abnormality of the prostate (HP:0008775)2.01976478
115Poor head control (HP:0002421)2.01277269
116Increased intramyocellular lipid droplets (HP:0012240)1.99134312
117Skin rash (HP:0000988)1.95331998
118Prolonged bleeding time (HP:0003010)1.93303055
119Purpura (HP:0000979)1.92041175
120Anorexia (HP:0002039)1.91885084
121Pancytopenia (HP:0001876)1.84316695
122Polyneuropathy (HP:0001271)1.84151605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.40976305
2BLK3.84117311
3TXK3.77418837
4MAP3K143.69554605
5TBK13.16887089
6TYK23.14060271
7RIPK43.07448397
8IKBKE2.90688479
9JAK32.87022402
10IRAK42.85271391
11PBK2.38901779
12ZAP702.35437047
13JAK12.15135173
14NME22.11436121
15KIT2.07777593
16SYK1.99679745
17IRAK31.98736527
18IKBKB1.98662877
19ERN11.93261012
20CSK1.85306655
21BCKDK1.79889587
22BTK1.77634767
23MST41.76963532
24FGFR41.72385049
25ITK1.70400996
26TEC1.64528141
27LCK1.62595368
28TESK21.48237227
29CSF1R1.45945885
30HCK1.45760848
31LYN1.44928978
32KDR1.42189857
33PIM21.40991970
34STK101.40262399
35MAP3K131.38834077
36MAP3K121.35972692
37TAOK31.34808725
38FGFR31.32170135
39SCYL21.29709164
40GRK61.29497253
41NEK91.20049827
42PIM11.11608581
43CHUK1.05367087
44NLK1.02996152
45TESK11.00768599
46RPS6KA41.00403142
47JAK20.98939746
48CLK10.94029822
49LRRK20.93690303
50SIK30.92295601
51PRKCQ0.90811354
52MARK30.88514456
53CAMKK20.88239823
54LIMK10.85834815
55STK40.84956357
56VRK20.84879190
57MYLK0.79539604
58FES0.72501308
59PASK0.71702915
60FGR0.69757733
61ZAK0.68252243
62BMPR20.67369825
63CAMKK10.65656597
64MAPKAPK30.63752210
65PRPF4B0.61316935
66PRKCH0.61221809
67PRKCD0.61159250
68MATK0.61018086
69SIK20.59497723
70EPHB10.58487271
71ABL10.57998167
72DAPK10.56574933
73TNK20.56486975
74ABL20.55728282
75TGFBR20.53248651
76VRK10.52949045
77MAP3K100.52716783
78FYN0.50601645
79EIF2AK10.50052106
80EIF2AK30.49222853
81TRPM70.48446309
82BMX0.47654399
83MUSK0.47027173
84IRAK10.46844204
85EIF2AK20.44146893
86TAOK20.44117128
87GRK70.43443771
88EGFR0.41314450
89GRK10.41208880
90IRAK20.40517988
91MAP2K20.40336614
92ADRBK20.39766657
93MAPK120.38510653
94INSR0.38087026
95MAP2K30.37317978
96PDK10.36930574
97EPHA30.36631379
98MAP3K30.35626493
99MAP3K50.32073355
100DAPK30.31804786
101RPS6KA50.31617108
102ACVR1B0.30253305
103YES10.29096316
104CDK190.27577514
105IGF1R0.26744060
106TTN0.26409402
107MAPKAPK20.26225000
108STK160.25556821
109MAP4K20.24531297
110MAPK30.23791599
111NUAK10.22904016
112TLK10.22820342
113MAP3K110.22029855
114HIPK20.21672778
115PRKCA0.20383052
116PIK3CG0.18201925
117ADRBK10.17761177
118MAP3K10.17512063
119MAP2K60.16825359
120MAPK70.16794130
121DMPK0.16721690
122RPS6KA60.16467841
123SRC0.15919796
124PDGFRB0.14035384
125MAPK110.13152153
126MST1R0.11780173
127CDK40.11694848
128ARAF0.11616364

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.83285550
2Graft-versus-host disease_Homo sapiens_hsa053323.76755625
3Allograft rejection_Homo sapiens_hsa053303.15468474
4Leishmaniasis_Homo sapiens_hsa051403.10653763
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.93032469
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.76955409
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.66565863
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.50099364
9Measles_Homo sapiens_hsa051622.48418851
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.43732603
11Antigen processing and presentation_Homo sapiens_hsa046122.30219803
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.29075777
13Asthma_Homo sapiens_hsa053102.25673330
14Osteoclast differentiation_Homo sapiens_hsa043802.18947190
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.17077774
16Hematopoietic cell lineage_Homo sapiens_hsa046402.11934793
17Legionellosis_Homo sapiens_hsa051342.06497154
18Staphylococcus aureus infection_Homo sapiens_hsa051502.04680133
19B cell receptor signaling pathway_Homo sapiens_hsa046621.99298178
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92310424
21T cell receptor signaling pathway_Homo sapiens_hsa046601.91039772
22Autoimmune thyroid disease_Homo sapiens_hsa053201.89592505
23Tuberculosis_Homo sapiens_hsa051521.86073985
24Pertussis_Homo sapiens_hsa051331.79614588
25Malaria_Homo sapiens_hsa051441.78061162
26Type I diabetes mellitus_Homo sapiens_hsa049401.76290308
27Viral myocarditis_Homo sapiens_hsa054161.69795935
28Herpes simplex infection_Homo sapiens_hsa051681.66999110
29Rheumatoid arthritis_Homo sapiens_hsa053231.61728751
30Influenza A_Homo sapiens_hsa051641.57628058
31Salmonella infection_Homo sapiens_hsa051321.53753536
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.50135849
33Chemokine signaling pathway_Homo sapiens_hsa040621.49782674
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49018912
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47066176
36Toxoplasmosis_Homo sapiens_hsa051451.42969574
37TNF signaling pathway_Homo sapiens_hsa046681.41112402
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39744025
39Shigellosis_Homo sapiens_hsa051311.37352248
40Lysosome_Homo sapiens_hsa041421.35991641
41Other glycan degradation_Homo sapiens_hsa005111.33482891
42Apoptosis_Homo sapiens_hsa042101.22388586
43African trypanosomiasis_Homo sapiens_hsa051431.16198173
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.15428902
45Phagosome_Homo sapiens_hsa041451.12803386
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10006019
47Hepatitis B_Homo sapiens_hsa051611.09148865
48Proteasome_Homo sapiens_hsa030500.90440502
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85038137
50Hepatitis C_Homo sapiens_hsa051600.84800801
51Oxidative phosphorylation_Homo sapiens_hsa001900.83264723
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75671479
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72858258
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72121944
55Acute myeloid leukemia_Homo sapiens_hsa052210.68879877
56Epstein-Barr virus infection_Homo sapiens_hsa051690.67433584
57Platelet activation_Homo sapiens_hsa046110.67043579
58Parkinsons disease_Homo sapiens_hsa050120.64387978
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62594722
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.62573433
61Pancreatic cancer_Homo sapiens_hsa052120.57880804
62HTLV-I infection_Homo sapiens_hsa051660.50095886
63Prolactin signaling pathway_Homo sapiens_hsa049170.48823660
64Viral carcinogenesis_Homo sapiens_hsa052030.47415884
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43605950
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41327093
67Protein export_Homo sapiens_hsa030600.39793537
68Amoebiasis_Homo sapiens_hsa051460.38775971
69Ribosome_Homo sapiens_hsa030100.37982231
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.37677182
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37623381
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36867529
73VEGF signaling pathway_Homo sapiens_hsa043700.34840621
74Phototransduction_Homo sapiens_hsa047440.33530269
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33511076
76Chronic myeloid leukemia_Homo sapiens_hsa052200.33334800
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.33198260
78Alzheimers disease_Homo sapiens_hsa050100.33017559
79Caffeine metabolism_Homo sapiens_hsa002320.32763635
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32397110
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32003233
82Endocytosis_Homo sapiens_hsa041440.29041916
83p53 signaling pathway_Homo sapiens_hsa041150.28560404
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28064823
85Linoleic acid metabolism_Homo sapiens_hsa005910.27458976
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26776617
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.26369519
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25704781
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24288097
90Prion diseases_Homo sapiens_hsa050200.23457488
91Base excision repair_Homo sapiens_hsa034100.21684565
92Collecting duct acid secretion_Homo sapiens_hsa049660.21123980
93Arachidonic acid metabolism_Homo sapiens_hsa005900.21104846
94Complement and coagulation cascades_Homo sapiens_hsa046100.20587419
95Olfactory transduction_Homo sapiens_hsa047400.17452420
96Peroxisome_Homo sapiens_hsa041460.16749669
97Small cell lung cancer_Homo sapiens_hsa052220.16738502
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16118050
99RNA polymerase_Homo sapiens_hsa030200.15546123
100HIF-1 signaling pathway_Homo sapiens_hsa040660.12418757
101DNA replication_Homo sapiens_hsa030300.12026300
102Pentose phosphate pathway_Homo sapiens_hsa000300.11490446
103Nitrogen metabolism_Homo sapiens_hsa009100.11485729
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10454425
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.08674305
106Colorectal cancer_Homo sapiens_hsa052100.07574575
107FoxO signaling pathway_Homo sapiens_hsa040680.07283145
108Homologous recombination_Homo sapiens_hsa034400.06313313
109ABC transporters_Homo sapiens_hsa020100.06262196
110Huntingtons disease_Homo sapiens_hsa050160.06249589
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.06230163
112MAPK signaling pathway_Homo sapiens_hsa040100.05844172
113Insulin resistance_Homo sapiens_hsa049310.05762706
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05741700
115Systemic lupus erythematosus_Homo sapiens_hsa053220.05679276
116Adherens junction_Homo sapiens_hsa045200.04989768
117Non-small cell lung cancer_Homo sapiens_hsa052230.04675357
118Regulation of autophagy_Homo sapiens_hsa041400.04198735
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.00435035
120Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0140226
121Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0138040
122Pyrimidine metabolism_Homo sapiens_hsa00240-0.0121349

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