CD55

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)7.42812653
2regulation of female gonad development (GO:2000194)5.33703439
3adenosine metabolic process (GO:0046085)4.96431622
4peripheral nervous system neuron development (GO:0048935)4.74653281
5desmosome organization (GO:0002934)4.64902457
6hemidesmosome assembly (GO:0031581)4.61120909
7iron ion import (GO:0097286)4.50070240
8negative regulation of glycoprotein biosynthetic process (GO:0010561)4.42788453
9neuronal action potential (GO:0019228)4.29848129
10behavioral response to pain (GO:0048266)4.26429840
11phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.24713824
12glomerular visceral epithelial cell development (GO:0072015)4.23866482
13regulation of platelet aggregation (GO:0090330)4.23528506
14* negative regulation of complement activation (GO:0045916)4.16805073
15ethanol oxidation (GO:0006069)4.04451974
16positive regulation of p38MAPK cascade (GO:1900745)3.98599202
17negative regulation of homotypic cell-cell adhesion (GO:0034111)3.98172174
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.94730554
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.94730554
20modulation by symbiont of host immune response (GO:0052553)3.94730554
21positive regulation by symbiont of host defense response (GO:0052509)3.94730554
22modulation by symbiont of host defense response (GO:0052031)3.94730554
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.94730554
24neutrophil activation involved in immune response (GO:0002283)3.93645981
25membrane budding (GO:0006900)3.92236479
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84952625
27antigen processing and presentation of endogenous antigen (GO:0019883)3.84805315
28negative regulation of protein autophosphorylation (GO:0031953)3.84192619
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.83387988
30glomerular epithelial cell development (GO:0072310)3.78249689
31* negative regulation of humoral immune response (GO:0002921)3.71248772
32lung lobe morphogenesis (GO:0060463)3.67458169
33response to water (GO:0009415)3.65658649
34potassium ion export (GO:0071435)3.64532799
35negative regulation of dendrite morphogenesis (GO:0050774)3.61831417
36detection of other organism (GO:0098543)3.55665385
37response to peptidoglycan (GO:0032494)3.52366390
38* negative regulation of protein activation cascade (GO:2000258)3.49920038
39response to laminar fluid shear stress (GO:0034616)3.48595345
40macrophage activation involved in immune response (GO:0002281)3.40580164
41production of molecular mediator involved in inflammatory response (GO:0002532)3.39140193
42detection of external biotic stimulus (GO:0098581)3.37273045
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.35887458
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.35887458
45angiotensin maturation (GO:0002003)3.35660146
46response to pain (GO:0048265)3.34777308
47antibacterial humoral response (GO:0019731)3.34453518
48primary alcohol catabolic process (GO:0034310)3.33815252
49positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.33181059
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.31690743
51ethanol metabolic process (GO:0006067)3.28896462
52antimicrobial humoral response (GO:0019730)3.28885423
53negative regulation of glycoprotein metabolic process (GO:1903019)3.25564360
54citrulline biosynthetic process (GO:0019240)3.23655024
55embryonic process involved in female pregnancy (GO:0060136)3.21879227
56neurofilament cytoskeleton organization (GO:0060052)3.19771272
57interleukin-6-mediated signaling pathway (GO:0070102)3.19699644
58glomerular basement membrane development (GO:0032836)3.19561544
59nuclear pore complex assembly (GO:0051292)3.19270344
60regulation of interferon-beta biosynthetic process (GO:0045357)3.18068138
61detection of bacterium (GO:0016045)3.17776083
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.17165106
63interferon-gamma secretion (GO:0072643)3.13414386
64cellular extravasation (GO:0045123)3.12857800
65negative regulation of immunoglobulin mediated immune response (GO:0002890)3.10972950
66negative regulation of B cell mediated immunity (GO:0002713)3.10972950
67germinal center formation (GO:0002467)3.10380899
68purine nucleotide salvage (GO:0032261)3.08901943
69definitive hemopoiesis (GO:0060216)3.06947797
70hepatocyte differentiation (GO:0070365)3.06542137
71macrophage activation (GO:0042116)3.04930049
72immunoglobulin mediated immune response (GO:0016064)3.02767051
73positive regulation of cell adhesion mediated by integrin (GO:0033630)3.00421090
74type B pancreatic cell proliferation (GO:0044342)3.00292975
75urea cycle (GO:0000050)2.97300955
76detection of temperature stimulus (GO:0016048)2.96740455
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93201684
78negative regulation of cell killing (GO:0031342)2.93201684
79response to ATP (GO:0033198)2.90545033
80thrombin receptor signaling pathway (GO:0070493)2.88381040
81phospholipid scrambling (GO:0017121)2.88093928
82negative regulation of lymphocyte mediated immunity (GO:0002707)2.87831193
83regulation of T-helper 2 cell differentiation (GO:0045628)2.87287255
84neutrophil activation (GO:0042119)2.85867310
85midgut development (GO:0007494)2.80926470
86lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80413647
87detection of biotic stimulus (GO:0009595)2.80185169
88regulation of p38MAPK cascade (GO:1900744)2.79339849
89positive regulation of respiratory burst (GO:0060267)2.79059485
90negative regulation of interleukin-12 production (GO:0032695)2.77817919
91response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.76641831
92response to host (GO:0075136)2.76641831
93response to host defenses (GO:0052200)2.76641831
94negative regulation of stress fiber assembly (GO:0051497)2.76175447
95regulation of gamma-delta T cell activation (GO:0046643)2.73991009
96regulation of platelet activation (GO:0010543)2.71328883
97regulation of necroptotic process (GO:0060544)2.68450764
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66601918
99response to host immune response (GO:0052572)2.66601918
100negative regulation of interleukin-8 production (GO:0032717)2.66455678
101citrulline metabolic process (GO:0000052)2.65276801
102regulation of B cell receptor signaling pathway (GO:0050855)2.64903293
103natural killer cell mediated cytotoxicity (GO:0042267)2.64873494
104natural killer cell mediated immunity (GO:0002228)2.64873494
105microglial cell activation (GO:0001774)2.64712286
106detection of temperature stimulus involved in sensory perception (GO:0050961)2.63851176
107detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.63851176
108positive regulation of cellular amide metabolic process (GO:0034250)2.63426744
109granulocyte activation (GO:0036230)2.63387274
110neutrophil mediated immunity (GO:0002446)2.62495884
111positive regulation of cardiac muscle hypertrophy (GO:0010613)2.61538422
112positive regulation of muscle hypertrophy (GO:0014742)2.61538422
113regulation of hypersensitivity (GO:0002883)2.60888648
114renal filtration (GO:0097205)2.59461686
115positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.58819464
116T-helper 1 type immune response (GO:0042088)2.58115432
117positive regulation of gamma-delta T cell activation (GO:0046645)2.57534326
118hypotonic response (GO:0006971)2.57401807
119water homeostasis (GO:0030104)2.57141921
120nuclear pore organization (GO:0006999)2.56865395
121negative regulation of platelet activation (GO:0010544)2.55736239
122valine metabolic process (GO:0006573)2.55481712
123urea metabolic process (GO:0019627)2.55413706
124O-glycan processing (GO:0016266)2.54531809
125pathway-restricted SMAD protein phosphorylation (GO:0060389)2.54513103
126negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.54319767
127opsonization (GO:0008228)2.53971616
128regulation of gamma-delta T cell differentiation (GO:0045586)2.53812079
129positive regulation of Cdc42 GTPase activity (GO:0043089)2.52955339
130negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.52028206
131regulation of water loss via skin (GO:0033561)2.51534466
132gland morphogenesis (GO:0022612)2.50084921
133regulation of coagulation (GO:0050818)2.49623378
134multicellular organismal water homeostasis (GO:0050891)2.49616934
135regulation of superoxide anion generation (GO:0032928)2.49100658
136B cell mediated immunity (GO:0019724)2.48279838
137negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.48140900
138negative regulation of T-helper cell differentiation (GO:0045623)2.48140900
139regulation of homotypic cell-cell adhesion (GO:0034110)2.47326823
140mesodermal cell differentiation (GO:0048333)2.46948127
141negative regulation of leukocyte mediated immunity (GO:0002704)2.46795414
142urinary tract smooth muscle contraction (GO:0014848)2.46693716
143establishment of skin barrier (GO:0061436)2.43827390
144sensory perception of smell (GO:0007608)2.43528888
145negative regulation of sodium ion transport (GO:0010766)2.43220046
146surfactant homeostasis (GO:0043129)2.42181940
147leukocyte aggregation (GO:0070486)2.41667334
148negative regulation of erythrocyte differentiation (GO:0045647)2.40718690
149regulation of mast cell activation involved in immune response (GO:0033006)2.38891021
150regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.38611479
151chemical homeostasis within a tissue (GO:0048875)2.37965161
152membrane raft organization (GO:0031579)2.37324427
153regulation of mast cell degranulation (GO:0043304)2.37302702
154response to growth hormone (GO:0060416)2.35860884
155myeloid cell activation involved in immune response (GO:0002275)2.35821587
156positive regulation of macrophage differentiation (GO:0045651)2.34992565
157regulation of cardiac muscle hypertrophy (GO:0010611)2.34156974
158detection of molecule of bacterial origin (GO:0032490)2.33825607
159activation of Rac GTPase activity (GO:0032863)2.32962634
160negative regulation of coagulation (GO:0050819)2.32232697
161positive regulation of interferon-alpha production (GO:0032727)2.31401645
162adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.31385278
163nitrogen cycle metabolic process (GO:0071941)2.30683152
164regulation of muscle hypertrophy (GO:0014743)2.29852989
165cell adhesion mediated by integrin (GO:0033627)2.29817377
166myoblast migration (GO:0051451)2.29258721
167antigen processing and presentation via MHC class Ib (GO:0002475)2.29254663
168regulation of leukocyte degranulation (GO:0043300)2.29254527
169regulation of blood coagulation (GO:0030193)2.29053825
170regulation of hemostasis (GO:1900046)2.29053825
171growth hormone receptor signaling pathway (GO:0060396)2.28641089
172leukocyte mediated cytotoxicity (GO:0001909)2.28575850
173mammary gland epithelial cell proliferation (GO:0033598)2.26092536
174transcytosis (GO:0045056)2.25983419
175negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.25916814
176positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.25886668
177fibroblast migration (GO:0010761)2.25718979
178hepatocyte apoptotic process (GO:0097284)2.22911303
179positive regulation of coagulation (GO:0050820)2.22708632
180atrioventricular valve morphogenesis (GO:0003181)2.22462523
181establishment of endothelial barrier (GO:0061028)2.22235385
182defense response to Gram-negative bacterium (GO:0050829)2.21812300
183vascular endothelial growth factor signaling pathway (GO:0038084)2.21719769
184negative regulation of granulocyte differentiation (GO:0030853)2.20643733
185B cell receptor signaling pathway (GO:0050853)2.19844072
186ovulation from ovarian follicle (GO:0001542)2.19275938
187organ induction (GO:0001759)2.19177106
188sensory perception of chemical stimulus (GO:0007606)2.18442995

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.43031134
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.98939386
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.62432539
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.16631696
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.13651626
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.07805911
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.94351484
8* ESR2_21235772_ChIP-Seq_MCF-7_Human2.69645405
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57590943
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.44750280
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.42810050
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.39340307
13* ESR1_20079471_ChIP-ChIP_T-47D_Human2.34512143
14ZNF263_19887448_ChIP-Seq_K562_Human2.21890125
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21050651
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.19926916
17GATA2_21666600_ChIP-Seq_HMVEC_Human2.19241214
18GATA1_22025678_ChIP-Seq_K562_Human2.05296794
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04593515
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98831717
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.97504478
22SCL_19346495_ChIP-Seq_HPC-7_Human1.89894956
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.87648070
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85821996
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85245177
26* SOX2_20726797_ChIP-Seq_SW620_Human1.82887623
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81625736
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.81323593
29RUNX_20019798_ChIP-Seq_JUKART_Human1.77256129
30* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76494164
31* CJUN_26792858_Chip-Seq_BT549_Human1.71699612
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71051135
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68454829
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68388438
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67678471
36TFEB_21752829_ChIP-Seq_HELA_Human1.67252787
37* SPI1_23547873_ChIP-Seq_NB4_Human1.65857684
38* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.64151612
39* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.64151612
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.63727996
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.58552231
42CLOCK_20551151_ChIP-Seq_293T_Human1.58336505
43SOX2_27498859_Chip-Seq_STOMACH_Mouse1.53133549
44* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52585726
45SPI1_23127762_ChIP-Seq_K562_Human1.48856348
46AHR_22903824_ChIP-Seq_MCF-7_Human1.48321739
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48258116
48TCF7_22412390_ChIP-Seq_EML_Mouse1.47873870
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45154062
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42683163
51FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.40290103
52VDR_24763502_ChIP-Seq_THP-1_Human1.40188648
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38390879
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35712306
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35659203
56* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33912438
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.33652304
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33604404
59* GATA4_25053715_ChIP-Seq_YYC3_Human1.33264359
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.31452401
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30974752
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30349780
63TP63_23658742_ChIP-Seq_EP156T_Human1.30184186
64GATA2_19941826_ChIP-Seq_K562_Human1.28781556
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26626567
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23848628
67* GATA3_24758297_ChIP-Seq_MCF-7_Human1.22021844
68* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21923426
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21104326
70JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20983487
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20440440
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19898808
73* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19189166
74* RUNX1_27514584_Chip-Seq_MCF-7_Human1.19176085
75UTX_26944678_Chip-Seq_JUKART_Human1.18852419
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16922746
77MYC_22102868_ChIP-Seq_BL_Human1.16359365
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.15445603
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15055976
80* NCOR1_26117541_ChIP-Seq_K562_Human1.14587416
81* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14386356
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14065370
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13459903
84PU_27001747_Chip-Seq_BMDM_Mouse1.12987677
85* MYB_26560356_Chip-Seq_TH2_Human1.12750168
86RXR_22108803_ChIP-Seq_LS180_Human1.12487434
87PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12466773
88VDR_21846776_ChIP-Seq_THP-1_Human1.11392181
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10468831
90* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09347528
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08767117
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.08266645
93ATF3_27146783_Chip-Seq_COLON_Human1.07877947
94* GATA6_25053715_ChIP-Seq_YYC3_Human1.07337861
95CDX2_20551321_ChIP-Seq_CACO-2_Human1.07184356
96KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06657593
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05548939
98EGR1_19032775_ChIP-ChIP_M12_Human1.05345849
99P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04312008
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03275280
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03045546
102* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02883093
103MAF_26560356_Chip-Seq_TH1_Human1.00824656
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99204219
105MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99140670
106GATA3_26560356_Chip-Seq_TH2_Human0.98448273
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98315444
108* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96773408
109BCAT_22108803_ChIP-Seq_LS180_Human0.96267130
110* UBF1/2_26484160_Chip-Seq_HMECs_Human0.95717427
111* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95662173
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.95413937
113* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95193611
114LXR_22158963_ChIP-Seq_LIVER_Mouse0.95177165
115* KDM2B_26808549_Chip-Seq_DND41_Human0.94964676
116VDR_24787735_ChIP-Seq_THP-1_Human0.94039840
117GATA1_19941826_ChIP-Seq_K562_Human0.93764469
118GATA3_27048872_Chip-Seq_THYMUS_Human0.93280392
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92635945
120* KLF5_25053715_ChIP-Seq_YYC3_Human0.92510037
121* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92431129
122LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91771149
123* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91769338
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90602359
125* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90365401
126CDX2_22108803_ChIP-Seq_LS180_Human0.89037746
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.88009132
128IRF8_27001747_Chip-Seq_BMDM_Mouse0.87449819
129* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87444972
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86586359
131RACK7_27058665_Chip-Seq_MCF-7_Human0.83857855
132MYB_26560356_Chip-Seq_TH1_Human0.83536233
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82945792
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82906471
135NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81841574
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81776684
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81776684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after4.91410136
2MP0001968_abnormal_touch/_nociception4.58005557
3MP0002735_abnormal_chemical_nociception4.29418124
4MP0010234_abnormal_vibrissa_follicle3.23563230
5MP0001986_abnormal_taste_sensitivity3.17443890
6MP0005275_abnormal_skin_tensile3.12238607
7MP0002254_reproductive_system_inflammat3.10819008
8MP0003436_decreased_susceptibility_to2.61944523
9MP0003656_abnormal_erythrocyte_physiolo2.57092570
10MP0003303_peritoneal_inflammation2.33668076
11MP0006054_spinal_hemorrhage2.32795458
12MP0008438_abnormal_cutaneous_collagen2.32433356
13MP0001958_emphysema2.24528913
14MP0008004_abnormal_stomach_pH2.22873052
15MP0003279_aneurysm2.09301469
16MP0002733_abnormal_thermal_nociception2.04739607
17MP0010352_gastrointestinal_tract_polyps2.00813241
18MP0008057_abnormal_DNA_replication2.00554394
19MP0003191_abnormal_cellular_cholesterol1.97966483
20MP0004782_abnormal_surfactant_physiolog1.96448709
21* MP0002419_abnormal_innate_immunity1.95803554
22MP0003566_abnormal_cell_adhesion1.94337663
23MP0010771_integument_phenotype1.78672794
24* MP0005000_abnormal_immune_tolerance1.71143104
25MP0003300_gastrointestinal_ulcer1.69965774
26MP0002060_abnormal_skin_morphology1.68651977
27MP0008875_abnormal_xenobiotic_pharmacok1.67545072
28MP0009785_altered_susceptibility_to1.64401316
29MP0005387_immune_system_phenotype1.63914448
30MP0001790_abnormal_immune_system1.63914448
31MP0002796_impaired_skin_barrier1.62828939
32MP0006082_CNS_inflammation1.60772478
33MP0001851_eye_inflammation1.59071355
34MP0005025_abnormal_response_to1.59021030
35MP0005451_abnormal_body_composition1.57469639
36MP0001533_abnormal_skeleton_physiology1.55478055
37MP0010368_abnormal_lymphatic_system1.53347443
38MP0005076_abnormal_cell_differentiation1.53104527
39MP0003724_increased_susceptibility_to1.50972041
40MP0002006_tumorigenesis1.49981958
41* MP0001800_abnormal_humoral_immune1.48576424
42MP0005023_abnormal_wound_healing1.46671745
43MP0004808_abnormal_hematopoietic_stem1.46154598
44MP0009384_cardiac_valve_regurgitation1.44365210
45MP0004264_abnormal_extraembryonic_tissu1.44009559
46MP0005503_abnormal_tendon_morphology1.38017129
47MP0002998_abnormal_bone_remodeling1.37574475
48MP0005360_urolithiasis1.36034709
49MP0003453_abnormal_keratinocyte_physiol1.34219547
50MP0001970_abnormal_pain_threshold1.33930169
51MP0004883_abnormal_blood_vessel1.33114224
52MP0001853_heart_inflammation1.32195574
53MP0003806_abnormal_nucleotide_metabolis1.32055798
54MP0002877_abnormal_melanocyte_morpholog1.31179858
55MP0000427_abnormal_hair_cycle1.31178616
56MP0003950_abnormal_plasma_membrane1.30889759
57MP0003705_abnormal_hypodermis_morpholog1.30364539
58MP0010678_abnormal_skin_adnexa1.28776313
59MP0002734_abnormal_mechanical_nocicepti1.25929647
60MP0001879_abnormal_lymphatic_vessel1.22829084
61MP0003075_altered_response_to1.22487558
62MP0000538_abnormal_urinary_bladder1.21462939
63MP0001835_abnormal_antigen_presentation1.20897515
64MP0009333_abnormal_splenocyte_physiolog1.19073069
65MP0000767_abnormal_smooth_muscle1.18389391
66MP0004947_skin_inflammation1.18299118
67MP0004858_abnormal_nervous_system1.17526220
68MP0000013_abnormal_adipose_tissue1.15639554
69MP0000685_abnormal_immune_system1.15077051
70MP0003763_abnormal_thymus_physiology1.15052815
71MP0000383_abnormal_hair_follicle1.13880638
72MP0005058_abnormal_lysosome_morphology1.13064529
73MP0003448_altered_tumor_morphology1.12128496
74MP0003045_fibrosis1.11154111
75MP0000716_abnormal_immune_system1.08748670
76MP0008260_abnormal_autophagy1.05833609
77MP0006276_abnormal_autonomic_nervous1.04909005
78MP0004381_abnormal_hair_follicle1.02855368
79MP0003183_abnormal_peptide_metabolism1.02648525
80MP0002452_abnormal_antigen_presenting1.01616515
81MP0001666_abnormal_nutrient_absorption1.01522655
82MP0002168_other_aberrant_phenotype1.01469287
83MP0009840_abnormal_foam_cell1.01142101
84MP0002166_altered_tumor_susceptibility1.00270484
85MP0004233_abnormal_muscle_weight0.99531531
86MP0001270_distended_abdomen0.99515424
87MP0000858_altered_metastatic_potential0.99169768
88MP0008469_abnormal_protein_level0.98209236
89MP0003091_abnormal_cell_migration0.97480768
90MP0009764_decreased_sensitivity_to0.96867007
91MP0005464_abnormal_platelet_physiology0.96212865
92MP0002429_abnormal_blood_cell0.95632810
93MP0005501_abnormal_skin_physiology0.94341270
94MP0002722_abnormal_immune_system0.94333415
95MP0001873_stomach_inflammation0.93659189
96MP0001216_abnormal_epidermal_layer0.93196378
97MP0000579_abnormal_nail_morphology0.92889977
98MP0000003_abnormal_adipose_tissue0.91700638
99MP0004185_abnormal_adipocyte_glucose0.91075271
100MP0009697_abnormal_copulation0.90696324
101MP0002132_abnormal_respiratory_system0.89577895
102MP0010155_abnormal_intestine_physiology0.88474838
103MP0005397_hematopoietic_system_phenotyp0.88199175
104MP0001545_abnormal_hematopoietic_system0.88199175
105MP0000490_abnormal_crypts_of0.87425652
106MP0009278_abnormal_bone_marrow0.87403117
107MP0000343_altered_response_to0.86516983
108MP0004147_increased_porphyrin_level0.85989896
109MP0002405_respiratory_system_inflammati0.85710169
110* MP0002136_abnormal_kidney_physiology0.85355741
111MP0009931_abnormal_skin_appearance0.84227170
112MP0005621_abnormal_cell_physiology0.83996433
113MP0000465_gastrointestinal_hemorrhage0.82952548
114MP0004019_abnormal_vitamin_homeostasis0.82220098
115MP0000703_abnormal_thymus_morphology0.82124696
116MP0002332_abnormal_exercise_endurance0.80905966
117MP0002009_preneoplasia0.80522492
118MP0001542_abnormal_bone_strength0.80092476
119MP0003795_abnormal_bone_structure0.79645108
120MP0002420_abnormal_adaptive_immunity0.77654856
121MP0002396_abnormal_hematopoietic_system0.77091121
122MP0001346_abnormal_lacrimal_gland0.76841783
123MP0003828_pulmonary_edema0.76614642
124* MP0005165_increased_susceptibility_to0.76022585
125MP0003866_abnormal_defecation0.75673583
126MP0002723_abnormal_immune_serum0.75549921
127MP0002933_joint_inflammation0.74937919
128MP0005395_other_phenotype0.74738549
129MP0000249_abnormal_blood_vessel0.74515742
130MP0001845_abnormal_inflammatory_respons0.73992828
131MP0005164_abnormal_response_to0.73535499
132MP0000689_abnormal_spleen_morphology0.73492437
133MP0000749_muscle_degeneration0.72645531
134MP0001819_abnormal_immune_cell0.72293220
135MP0005083_abnormal_biliary_tract0.72198313
136MP0004484_altered_response_of0.69862251
137MP0001984_abnormal_olfaction0.69516079
138MP0000681_abnormal_thyroid_gland0.67440678
139MP0005166_decreased_susceptibility_to0.67179895
140MP0002148_abnormal_hypersensitivity_rea0.66812003
141MP0002398_abnormal_bone_marrow0.66752894
142MP0004272_abnormal_basement_membrane0.66569760

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)4.62158800
2Aortic aneurysm (HP:0004942)4.49977929
3Eczematoid dermatitis (HP:0000976)4.47506796
4Subacute progressive viral hepatitis (HP:0006572)3.86059872
5Dysautonomia (HP:0002459)3.81687891
6Recurrent bacterial skin infections (HP:0005406)3.66436542
7Recurrent abscess formation (HP:0002722)3.63054407
8Autoimmune thrombocytopenia (HP:0001973)3.62050009
9Distal arthrogryposis (HP:0005684)3.58698241
10Lip pit (HP:0100267)3.55582954
11Distal lower limb muscle weakness (HP:0009053)3.53118428
12Vascular tortuosity (HP:0004948)3.43130192
13Hyporeflexia of lower limbs (HP:0002600)3.37665203
14Abnormality of macrophages (HP:0004311)3.37502913
15Agammaglobulinemia (HP:0004432)3.37073335
16Myositis (HP:0100614)3.35966485
17Orchitis (HP:0100796)3.35351942
18Onycholysis (HP:0001806)3.27836646
19Arterial tortuosity (HP:0005116)3.21374371
20Gastrointestinal stroma tumor (HP:0100723)3.19050899
21Mesangial abnormality (HP:0001966)3.08129299
22Recurrent bronchitis (HP:0002837)3.06807894
23Elevated erythrocyte sedimentation rate (HP:0003565)3.02160521
24Atrophic scars (HP:0001075)3.02021367
25Interstitial pulmonary disease (HP:0006530)3.01525288
26Optic neuritis (HP:0100653)2.94171556
27Retrobulbar optic neuritis (HP:0100654)2.94171556
28Wrist flexion contracture (HP:0001239)2.91636407
29Segmental peripheral demyelination/remyelination (HP:0003481)2.90531449
30Metaphyseal dysplasia (HP:0100255)2.84212999
31Milia (HP:0001056)2.83913464
32Emphysema (HP:0002097)2.82046597
33Pustule (HP:0200039)2.76464436
34Right ventricular cardiomyopathy (HP:0011663)2.70280066
35Viral hepatitis (HP:0006562)2.68588532
36Bronchitis (HP:0012387)2.68191225
37Aortic dissection (HP:0002647)2.66577620
38Arthropathy (HP:0003040)2.65460418
39Facial diplegia (HP:0001349)2.65135819
40Spontaneous hematomas (HP:0007420)2.61828202
41Broad metatarsal (HP:0001783)2.61733590
42Abnormality of the nasal mucosa (HP:0000433)2.61318596
43Short nail (HP:0001799)2.61297437
44Increased CSF protein (HP:0002922)2.60137796
45Cellulitis (HP:0100658)2.59532229
46Gingivitis (HP:0000230)2.58229158
47Impaired pain sensation (HP:0007328)2.56375026
48Abnormality of pain sensation (HP:0010832)2.56375026
49Micronodular cirrhosis (HP:0001413)2.54847805
50Recurrent gram-negative bacterial infections (HP:0005420)2.54098717
51Recurrent sinusitis (HP:0011108)2.53965492
52Hypothermia (HP:0002045)2.53893489
53Focal segmental glomerulosclerosis (HP:0000097)2.51871999
54Papilloma (HP:0012740)2.50449167
55Verrucae (HP:0200043)2.50449167
56Nasal polyposis (HP:0100582)2.49347575
57Spondylolisthesis (HP:0003302)2.48126245
58Impaired platelet aggregation (HP:0003540)2.47289695
59Abnormal platelet function (HP:0011869)2.47289695
60Increased IgE level (HP:0003212)2.46576543
61Increased connective tissue (HP:0009025)2.45543982
62Keratoconjunctivitis sicca (HP:0001097)2.45509506
63Abnormal hemoglobin (HP:0011902)2.45075077
64Gastrointestinal infarctions (HP:0005244)2.43377541
65Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.42395527
66Mediastinal lymphadenopathy (HP:0100721)2.40127031
67Areflexia of lower limbs (HP:0002522)2.40086576
68Fragile skin (HP:0001030)2.37742598
69Malnutrition (HP:0004395)2.36577400
70Episodic fever (HP:0001954)2.34898195
71Distal lower limb amyotrophy (HP:0008944)2.34695751
72Thyroid carcinoma (HP:0002890)2.33391537
73Xerostomia (HP:0000217)2.33039270
74Absent phalangeal crease (HP:0006109)2.32467593
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.32456865
76Osteolytic defects of the hand bones (HP:0009699)2.32456865
77Urticaria (HP:0001025)2.30606248
78Colitis (HP:0002583)2.28753424
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.27464627
80Abnormality of glycolipid metabolism (HP:0010969)2.27464627
81Abnormality of liposaccharide metabolism (HP:0010968)2.27464627
82Stomatitis (HP:0010280)2.26734289
83Recurrent skin infections (HP:0001581)2.25353489
84Chronic otitis media (HP:0000389)2.25130908
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.24380635
86Fatigue (HP:0012378)2.24347661
87Ulnar bowing (HP:0003031)2.23004952
88Mitral stenosis (HP:0001718)2.21587345
89Abnormality of the distal phalanges of the toes (HP:0010182)2.18036775
90Keratoconjunctivitis (HP:0001096)2.16667478
91Myocardial infarction (HP:0001658)2.16579327
92Chronic sinusitis (HP:0011109)2.15239938
93Vasculitis (HP:0002633)2.15053767
94Petechiae (HP:0000967)2.15000935
95Obstructive lung disease (HP:0006536)2.13757970
96Chronic obstructive pulmonary disease (HP:0006510)2.13757970
97Glomerulosclerosis (HP:0000096)2.12422889
98Steppage gait (HP:0003376)2.11911503
99Osteomyelitis (HP:0002754)2.11613216
100Striae distensae (HP:0001065)2.10856629
101Recurrent otitis media (HP:0000403)2.10453401
102Sparse lateral eyebrow (HP:0005338)2.10297897
103Chronic bronchitis (HP:0004469)2.10266221
104Loss of speech (HP:0002371)2.10124484
105Fragile nails (HP:0001808)2.09496395
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.08235832
107Cerebral aneurysm (HP:0004944)2.06192444
108Purpura (HP:0000979)2.04816525
109Nephritis (HP:0000123)2.04230015
110Recurrent fungal infections (HP:0002841)2.04061588
111Hypoalbuminemia (HP:0003073)2.03748280
112Abnormal albumin level (HP:0012116)2.03748280
113Alkalosis (HP:0001948)2.03635970
114Autoimmune hemolytic anemia (HP:0001890)2.01834798
115Amyloidosis (HP:0011034)2.00540176
116Ankyloglossia (HP:0010296)2.00052247
117Arterial thrombosis (HP:0004420)1.98818189
118Foot dorsiflexor weakness (HP:0009027)1.98679599
119Meningitis (HP:0001287)1.98480318
120Premature rupture of membranes (HP:0001788)1.98183362
121Facial shape deformation (HP:0011334)1.98012054
122Potter facies (HP:0002009)1.98012054
123Chest pain (HP:0100749)1.97856917
124Stridor (HP:0010307)1.97197126
125Dilatation of the ascending aorta (HP:0005111)1.96414793
126Insidious onset (HP:0003587)1.96244969
127Termporal pattern (HP:0011008)1.96244969
128Metaphyseal cupping (HP:0003021)1.96221889
129Polycythemia (HP:0001901)1.95987752
130Submucous cleft hard palate (HP:0000176)1.95306281
131Vertebral compression fractures (HP:0002953)1.94554087
132Prolonged bleeding time (HP:0003010)1.94265635
133Hematochezia (HP:0002573)1.94177836
134Abnormality of the fingertips (HP:0001211)1.92926829
135Inflammation of the large intestine (HP:0002037)1.91764159
136Recurrent viral infections (HP:0004429)1.91029130
137Wormian bones (HP:0002645)1.90950967
138Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89687150
139Gingival bleeding (HP:0000225)1.89149333
140Acanthosis nigricans (HP:0000956)1.88377402
141Cardiovascular calcification (HP:0011915)1.88294861
142Anorexia (HP:0002039)1.88040317
143Pulmonary infiltrates (HP:0002113)1.87742241
144Abnormal delayed hypersensitivity skin test (HP:0002963)1.86798318
145Reduced subcutaneous adipose tissue (HP:0003758)1.86521113
146Hemoptysis (HP:0002105)1.85834036
147Absent frontal sinuses (HP:0002688)1.85777861
148Menstrual irregularities (HP:0000858)1.83860491
149Sepsis (HP:0100806)1.83485782
150Bradycardia (HP:0001662)1.83444903
151Cone-rod dystrophy (HP:0000548)1.83026250
152Protrusio acetabuli (HP:0003179)1.82992659
153Plantar hyperkeratosis (HP:0007556)1.82787654
154Abnormality of oral frenula (HP:0000190)1.82667353
155Periodontitis (HP:0000704)1.82433540
156Abnormality of T cell physiology (HP:0011840)1.82408672
157Prominent nose (HP:0000448)1.81819926
158Ankle contracture (HP:0006466)1.81076147
159Aplasia cutis congenita (HP:0001057)1.81033636
160Epistaxis (HP:0000421)1.80976653
161Lymphopenia (HP:0001888)1.80782782
162Bowing of the arm (HP:0006488)1.80401757
163Bowed forearm bones (HP:0003956)1.80401757
164Gangrene (HP:0100758)1.80338157
165Alveolar cell carcinoma (HP:0006519)1.79337637
166Dehydration (HP:0001944)1.79070390
167Slow saccadic eye movements (HP:0000514)1.78229737
168Thick nail (HP:0001805)1.77423136
169Peritonitis (HP:0002586)1.77142771
170Cheilitis (HP:0100825)1.73964760
171Abnormality of the peritoneum (HP:0002585)1.73514326
172Neoplasm of the tracheobronchial system (HP:0100552)1.72370864
173Entropion (HP:0000621)1.70020465
174Gastrointestinal inflammation (HP:0004386)1.68959132
175Abnormality of T cell number (HP:0011839)1.68578340
176Lower limb hyperreflexia (HP:0002395)1.68213838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK33.82737928
2MST43.46220739
3TGFBR22.74835347
4EPHA32.71378533
5STK102.64060534
6MAP4K12.48274712
7BMPR22.46997185
8LRRK22.45318930
9RIPK42.41305690
10FRK2.39604175
11MAP3K22.13260341
12ERN12.04985453
13PRPF4B1.98502996
14MARK31.93605009
15SIK31.90181149
16FER1.79215578
17FGFR41.78353337
18NEK91.75992668
19IRAK41.74922605
20EEF2K1.72108938
21TRPM71.70491309
22FGFR31.70365930
23CSK1.65008935
24NEK61.63387236
25MATK1.62083810
26KSR21.57917022
27MAP3K91.54777501
28EPHB11.52395249
29IRAK31.49876638
30MAP2K11.43924773
31EIF2AK31.43155153
32GRK61.40854917
33MAP3K31.39155397
34LMTK21.38454360
35BLK1.38210740
36MAP2K21.36188849
37CDK121.33559015
38MST1R1.32420759
39BRD41.29790999
40YES11.28255536
41JAK11.28224654
42AKT31.27780229
43MAP3K131.26292956
44TYK21.19278715
45RET1.16017147
46NTRK11.15324208
47RPS6KB21.14699857
48TIE11.13105796
49NLK1.10664479
50GRK11.10150545
51IRAK11.09896648
52JAK31.09738408
53EPHA21.05636262
54SGK31.05603315
55TAOK21.04752525
56HCK1.04748108
57PBK1.03488680
58PDPK11.03369123
59MAP2K31.03129139
60RIPK11.02339863
61SGK21.02261970
62MAP3K11.02119329
63ZAP701.00614040
64STK240.97982403
65FGFR20.97307176
66EIF2AK10.97051479
67STK390.95511540
68SCYL20.93675457
69MAP3K140.93669217
70LATS20.93240528
71SIK10.93083892
72PRKG20.92772428
73ERBB30.91541296
74LIMK10.90172235
75TEC0.89207419
76GRK50.87716842
77OXSR10.83196890
78HIPK20.80635622
79PAK40.79014987
80MAP3K70.77638604
81MOS0.77365274
82RAF10.77307788
83BRSK20.76714162
84TTN0.74576273
85TAOK30.74298189
86LATS10.71508217
87FES0.70978062
88IKBKB0.70827381
89IRAK20.69664691
90RPS6KA20.68125836
91MAP3K60.67277346
92PDGFRB0.67045513
93TXK0.66191579
94CDK60.66055642
95MAP2K60.66026983
96STK380.65645773
97MAP3K100.65138359
98SYK0.62444389
99EPHB20.61907042
100MELK0.60883561
101SGK2230.60074719
102SGK4940.60074719
103NME20.59163137
104ARAF0.58160546
105TBK10.57615934
106KDR0.56829607
107MAP3K120.56442519
108JAK20.56357676
109MAPKAPK20.56204835
110WNK10.55776184
111KSR10.54826316
112PTK20.54804727
113WNK40.54381783
114STK30.53714319
115PIM20.53643049
116MAPK120.53329438
117MARK20.52200879
118IKBKE0.51722027
119TNK20.51032581
120BTK0.50775464
121MAPKAPK50.49253405
122PHKG20.49070357
123PHKG10.49070357
124BMX0.49040454
125PTK60.48805933
126PRKAA20.47312272
127STK38L0.47158639
128TAOK10.45142629
129LYN0.43762720
130PIM10.43678612
131MAPK110.43490689
132MYLK0.43111403
133MAPK150.43054575
134LCK0.42529293
135MAPK70.41663158
136CDK80.40837336
137MAP3K50.40770782
138TESK10.40382281
139CDK90.36718513
140DAPK20.36671249
141MAP3K80.36314700
142PDK10.35445064
143MET0.35364152
144ADRBK10.32693413
145PDK20.32092305
146PRKCQ0.31930262
147MAP3K110.31478029

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046143.84441458
2Caffeine metabolism_Homo sapiens_hsa002323.31354475
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.99019936
4B cell receptor signaling pathway_Homo sapiens_hsa046621.95896825
5Staphylococcus aureus infection_Homo sapiens_hsa051501.92039120
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.90767422
7Legionellosis_Homo sapiens_hsa051341.90734540
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86766452
9Graft-versus-host disease_Homo sapiens_hsa053321.79679285
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.79576823
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77476719
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.75511135
13Autoimmune thyroid disease_Homo sapiens_hsa053201.71898410
14Other glycan degradation_Homo sapiens_hsa005111.71846682
15Measles_Homo sapiens_hsa051621.70239201
16* Hematopoietic cell lineage_Homo sapiens_hsa046401.66730009
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64166721
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59976492
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.58835783
20Allograft rejection_Homo sapiens_hsa053301.56160239
21Chemical carcinogenesis_Homo sapiens_hsa052041.52147916
22Histidine metabolism_Homo sapiens_hsa003401.48870826
23ECM-receptor interaction_Homo sapiens_hsa045121.47645120
24Mineral absorption_Homo sapiens_hsa049781.42800579
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42296781
26Protein digestion and absorption_Homo sapiens_hsa049741.41564092
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41530727
28Thyroid cancer_Homo sapiens_hsa052161.41043377
29Antigen processing and presentation_Homo sapiens_hsa046121.38998450
30Primary immunodeficiency_Homo sapiens_hsa053401.38312447
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37923170
32Herpes simplex infection_Homo sapiens_hsa051681.35260707
33Toxoplasmosis_Homo sapiens_hsa051451.31116889
34Arginine biosynthesis_Homo sapiens_hsa002201.29448332
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28941755
36Renal cell carcinoma_Homo sapiens_hsa052111.24813396
37Amoebiasis_Homo sapiens_hsa051461.23512258
38Dorso-ventral axis formation_Homo sapiens_hsa043201.23084151
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20361562
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19515290
41* Viral myocarditis_Homo sapiens_hsa054161.18900797
42Type I diabetes mellitus_Homo sapiens_hsa049401.18339227
43Phagosome_Homo sapiens_hsa041451.16439726
44Asthma_Homo sapiens_hsa053101.15684806
45Glycerolipid metabolism_Homo sapiens_hsa005611.12611931
46Non-small cell lung cancer_Homo sapiens_hsa052231.11131059
47Pancreatic cancer_Homo sapiens_hsa052121.10233192
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.10066673
49Platelet activation_Homo sapiens_hsa046111.05664559
50Adherens junction_Homo sapiens_hsa045201.05328498
51Leishmaniasis_Homo sapiens_hsa051401.03784720
52Salmonella infection_Homo sapiens_hsa051321.02820376
53Rheumatoid arthritis_Homo sapiens_hsa053231.02714733
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01476957
55Lysosome_Homo sapiens_hsa041421.01389205
56T cell receptor signaling pathway_Homo sapiens_hsa046600.98120318
57Proteoglycans in cancer_Homo sapiens_hsa052050.97914545
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96143872
59VEGF signaling pathway_Homo sapiens_hsa043700.95727963
60Chemokine signaling pathway_Homo sapiens_hsa040620.94414192
61Prolactin signaling pathway_Homo sapiens_hsa049170.94077469
62Thyroid hormone synthesis_Homo sapiens_hsa049180.94029112
63Bladder cancer_Homo sapiens_hsa052190.92171682
64Olfactory transduction_Homo sapiens_hsa047400.91914263
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91633770
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91568896
67Viral carcinogenesis_Homo sapiens_hsa052030.91316702
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91314201
69Fat digestion and absorption_Homo sapiens_hsa049750.91134507
70Chronic myeloid leukemia_Homo sapiens_hsa052200.89774663
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89555998
72Apoptosis_Homo sapiens_hsa042100.89164286
73GnRH signaling pathway_Homo sapiens_hsa049120.89120350
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.88922675
75Tyrosine metabolism_Homo sapiens_hsa003500.88606959
76Osteoclast differentiation_Homo sapiens_hsa043800.88088362
77TGF-beta signaling pathway_Homo sapiens_hsa043500.87010390
78mTOR signaling pathway_Homo sapiens_hsa041500.86930207
79African trypanosomiasis_Homo sapiens_hsa051430.86745392
80Small cell lung cancer_Homo sapiens_hsa052220.85249447
81Hepatitis C_Homo sapiens_hsa051600.84399969
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.83633330
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.82724374
84Fatty acid degradation_Homo sapiens_hsa000710.82302008
85Bile secretion_Homo sapiens_hsa049760.82296469
86Shigellosis_Homo sapiens_hsa051310.82168600
87Focal adhesion_Homo sapiens_hsa045100.81901102
88* Complement and coagulation cascades_Homo sapiens_hsa046100.81747751
89HIF-1 signaling pathway_Homo sapiens_hsa040660.78467958
90Regulation of autophagy_Homo sapiens_hsa041400.76991019
91Rap1 signaling pathway_Homo sapiens_hsa040150.75249387
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74378798
93Starch and sucrose metabolism_Homo sapiens_hsa005000.73743847
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73559100
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71953716
96Insulin resistance_Homo sapiens_hsa049310.71823379
97Malaria_Homo sapiens_hsa051440.71458670
98HTLV-I infection_Homo sapiens_hsa051660.71228900
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70939279
100Choline metabolism in cancer_Homo sapiens_hsa052310.70864024
101Sphingolipid metabolism_Homo sapiens_hsa006000.68890590
102Nitrogen metabolism_Homo sapiens_hsa009100.68744183
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67237191
104TNF signaling pathway_Homo sapiens_hsa046680.66487924
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65835492
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65427571
107Circadian rhythm_Homo sapiens_hsa047100.65156902
108Influenza A_Homo sapiens_hsa051640.64412021
109Arachidonic acid metabolism_Homo sapiens_hsa005900.64370947
110Gastric acid secretion_Homo sapiens_hsa049710.64312313
111Ovarian steroidogenesis_Homo sapiens_hsa049130.64122744
112ABC transporters_Homo sapiens_hsa020100.63787671
113Pathways in cancer_Homo sapiens_hsa052000.62863588
114FoxO signaling pathway_Homo sapiens_hsa040680.62812989
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.61563090
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.60457946
117Inositol phosphate metabolism_Homo sapiens_hsa005620.60377337
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.60224835
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59739964
120Phenylalanine metabolism_Homo sapiens_hsa003600.58361120
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58239473
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58210922
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58051493
124Retinol metabolism_Homo sapiens_hsa008300.57493396
125Insulin signaling pathway_Homo sapiens_hsa049100.56712352
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.56364786
127Endometrial cancer_Homo sapiens_hsa052130.56201611
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.55869937
129ErbB signaling pathway_Homo sapiens_hsa040120.55547839
130Tuberculosis_Homo sapiens_hsa051520.55406903
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54943031
132p53 signaling pathway_Homo sapiens_hsa041150.54500726
133Acute myeloid leukemia_Homo sapiens_hsa052210.54450386
134Endocytosis_Homo sapiens_hsa041440.53487485
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53219070
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.52853717
137Vitamin digestion and absorption_Homo sapiens_hsa049770.52329424
138Pertussis_Homo sapiens_hsa051330.51709024
139Prostate cancer_Homo sapiens_hsa052150.51433106
140Pancreatic secretion_Homo sapiens_hsa049720.51143489
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50671262
142Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49808632
143Hepatitis B_Homo sapiens_hsa051610.49740272
144beta-Alanine metabolism_Homo sapiens_hsa004100.48116896
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.47328997

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