CD58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)4.48713440
2cytidine metabolic process (GO:0046087)3.96843591
3cytidine catabolic process (GO:0006216)3.96843591
4cytidine deamination (GO:0009972)3.96843591
5B cell mediated immunity (GO:0019724)3.91168308
6neutrophil activation involved in immune response (GO:0002283)3.88091552
7positive regulation of gamma-delta T cell activation (GO:0046645)3.85833898
8negative regulation of interleukin-12 production (GO:0032695)3.76460782
9response to peptidoglycan (GO:0032494)3.75271507
10regulation of B cell receptor signaling pathway (GO:0050855)3.72581013
11interferon-gamma-mediated signaling pathway (GO:0060333)3.55436012
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54342921
13DNA deamination (GO:0045006)3.50938839
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.50403783
15pyrimidine ribonucleoside catabolic process (GO:0046133)3.35317869
16response to interferon-beta (GO:0035456)3.27277095
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26838341
18Arp2/3 complex-mediated actin nucleation (GO:0034314)3.26707608
19regulation of chronic inflammatory response (GO:0002676)3.11733814
20cellular response to type I interferon (GO:0071357)3.11658280
21type I interferon signaling pathway (GO:0060337)3.11658280
22antigen processing and presentation of endogenous antigen (GO:0019883)3.11349291
23granulocyte activation (GO:0036230)3.08556238
24positive regulation of alpha-beta T cell proliferation (GO:0046641)3.08302396
25T cell migration (GO:0072678)3.07055896
26neutrophil activation (GO:0042119)3.06636011
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05792586
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05792586
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.05792586
30modulation by symbiont of host immune response (GO:0052553)3.05792586
31positive regulation by symbiont of host defense response (GO:0052509)3.05792586
32modulation by symbiont of host defense response (GO:0052031)3.05792586
33negative regulation of viral genome replication (GO:0045071)3.05714168
34regulation of alpha-beta T cell proliferation (GO:0046640)3.05018776
35response to type I interferon (GO:0034340)3.04643993
36regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00189829
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.99935160
38negative regulation of cell killing (GO:0031342)2.99935160
39antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.99666916
40lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97011424
41T-helper 1 type immune response (GO:0042088)2.95317211
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.95292066
43mast cell activation (GO:0045576)2.94048721
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90986212
45positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.90851424
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.89726418
47detection of other organism (GO:0098543)2.89077680
48detection of molecule of bacterial origin (GO:0032490)2.88290891
49defense response to protozoan (GO:0042832)2.88117849
50regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.86522489
51mature B cell differentiation involved in immune response (GO:0002313)2.85873309
52* cellular response to interferon-gamma (GO:0071346)2.84960895
53positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.83069030
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.82612499
55regulation of T-helper 1 cell differentiation (GO:0045625)2.82113458
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.81783476
57negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.81200333
58regulation of interferon-beta biosynthetic process (GO:0045357)2.80947347
59myeloid cell activation involved in immune response (GO:0002275)2.79059014
60regulation of interferon-alpha production (GO:0032647)2.77572238
61regulation of interleukin-2 biosynthetic process (GO:0045076)2.77269595
62positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.76879445
63response to protozoan (GO:0001562)2.75221238
64detection of bacterium (GO:0016045)2.74640614
65leukocyte degranulation (GO:0043299)2.74092902
66regulation of inflammatory response to antigenic stimulus (GO:0002861)2.73900509
67lymphocyte chemotaxis (GO:0048247)2.73849477
68regulation of antigen processing and presentation (GO:0002577)2.73304834
69regulation of hypersensitivity (GO:0002883)2.71318488
70positive regulation of interferon-alpha production (GO:0032727)2.68500455
71negative regulation of myeloid cell apoptotic process (GO:0033033)2.68233636
72detection of external biotic stimulus (GO:0098581)2.66765291
73positive regulation of defense response to virus by host (GO:0002230)2.66732187
74myeloid dendritic cell activation (GO:0001773)2.66658666
75positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.65870702
76actin nucleation (GO:0045010)2.65866974
77* response to interferon-gamma (GO:0034341)2.65432043
78cellular response to interleukin-15 (GO:0071350)2.64751471
79macrophage activation involved in immune response (GO:0002281)2.64290182
80NIK/NF-kappaB signaling (GO:0038061)2.63801207
81positive regulation of B cell differentiation (GO:0045579)2.63221570
82T cell costimulation (GO:0031295)2.62979708
83regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.62291118
84antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.59500835
85lymphocyte costimulation (GO:0031294)2.59337226
86positive regulation of mast cell activation (GO:0033005)2.57818802
87regulation of dendritic cell antigen processing and presentation (GO:0002604)2.57258641
88proteasome assembly (GO:0043248)2.57021567
89positive regulation of interleukin-17 production (GO:0032740)2.55301287
90positive regulation of antigen processing and presentation (GO:0002579)2.54883616
91cellular extravasation (GO:0045123)2.54271818
92myeloid dendritic cell differentiation (GO:0043011)2.53558098
93regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.52845177
94regulation of T cell tolerance induction (GO:0002664)2.50812316
95regulation of gamma-delta T cell activation (GO:0046643)2.50378791
96positive regulation of B cell mediated immunity (GO:0002714)2.50038011
97positive regulation of immunoglobulin mediated immune response (GO:0002891)2.50038011
98positive regulation of lymphocyte migration (GO:2000403)2.48553657
99regulation of mononuclear cell migration (GO:0071675)2.48476344
100regulation of interleukin-12 production (GO:0032655)2.48125619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.61106027
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.44266829
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.11965004
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.79335302
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.37834287
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.34828392
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.34239034
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99055655
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78462733
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.76483231
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.73973176
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.61114954
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.59281547
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58394765
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.48434170
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44965962
17SPI1_23547873_ChIP-Seq_NB4_Human2.43300358
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41006261
19MYB_26560356_Chip-Seq_TH2_Human2.33784535
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28009982
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19544434
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19521437
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14953618
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14632868
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04372852
26VDR_23849224_ChIP-Seq_CD4+_Human2.00759444
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.97157406
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85946639
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82175775
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77578527
31GATA1_22025678_ChIP-Seq_K562_Human1.72820003
32* MYB_26560356_Chip-Seq_TH1_Human1.72242238
33RUNX_20019798_ChIP-Seq_JUKART_Human1.69018870
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68860785
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66268741
36GATA3_26560356_Chip-Seq_TH2_Human1.65022526
37ELK1_19687146_ChIP-ChIP_HELA_Human1.64456124
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62597369
39FOXP3_21729870_ChIP-Seq_TREG_Human1.57464727
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50399658
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50200411
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.50127073
43* GATA3_27048872_Chip-Seq_THYMUS_Human1.45141265
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44029234
45* MAF_26560356_Chip-Seq_TH1_Human1.43046370
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.37509069
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35378186
48TFEB_21752829_ChIP-Seq_HELA_Human1.34363648
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32915315
50* SPI1_23127762_ChIP-Seq_K562_Human1.32734373
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32409960
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31025011
53SCL_19346495_ChIP-Seq_HPC-7_Human1.29227524
54VDR_24763502_ChIP-Seq_THP-1_Human1.29044627
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27482824
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26860732
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24889846
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24062642
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.23605074
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.23278744
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22427886
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22151579
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21684706
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18952233
65VDR_24787735_ChIP-Seq_THP-1_Human1.16569706
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15361120
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15237887
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.12944188
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12077817
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11834965
71UTX_26944678_Chip-Seq_JUKART_Human1.05939182
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05402818
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04653365
74ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03703034
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.02777893
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01609724
77DCP1A_22483619_ChIP-Seq_HELA_Human0.99974801
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99799414
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98444954
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97353043
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96460353
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95775330
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95185173
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94357368
85PU_27001747_Chip-Seq_BMDM_Mouse0.94161652
86MAF_26560356_Chip-Seq_TH2_Human0.94025287
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92894714
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92119445
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91298990
90E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90951304
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90661782
92* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89344626
93MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89195116
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88134057
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87878455
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87591086
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87107777
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86205003
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82366542
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81924408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.08460040
2MP0005671_abnormal_response_to3.69482497
3MP0002148_abnormal_hypersensitivity_rea3.41835699
4MP0009785_altered_susceptibility_to3.38364876
5MP0003436_decreased_susceptibility_to2.98047395
6MP0003806_abnormal_nucleotide_metabolis2.97670396
7MP0000685_abnormal_immune_system2.93650371
8MP0005000_abnormal_immune_tolerance2.93515607
9MP0003724_increased_susceptibility_to2.90315416
10MP0001800_abnormal_humoral_immune2.80488404
11MP0006082_CNS_inflammation2.77978924
12MP0001790_abnormal_immune_system2.76594800
13MP0005387_immune_system_phenotype2.76594800
14MP0003303_peritoneal_inflammation2.72174623
15MP0002452_abnormal_antigen_presenting2.60799801
16MP0005025_abnormal_response_to2.58348612
17MP0002419_abnormal_innate_immunity2.57946902
18MP0002723_abnormal_immune_serum2.57343214
19MP0002420_abnormal_adaptive_immunity2.32410768
20MP0001819_abnormal_immune_cell2.31293382
21MP0009764_decreased_sensitivity_to2.08109602
22MP0003763_abnormal_thymus_physiology2.04609607
23MP0001853_heart_inflammation2.04516741
24MP0009333_abnormal_splenocyte_physiolog1.98975512
25MP0001845_abnormal_inflammatory_respons1.90504163
26MP0005464_abnormal_platelet_physiology1.84842983
27MP0002166_altered_tumor_susceptibility1.82258889
28MP0002405_respiratory_system_inflammati1.80615756
29MP0010155_abnormal_intestine_physiology1.75737327
30MP0000716_abnormal_immune_system1.75267402
31MP0002398_abnormal_bone_marrow1.73880552
32MP0000343_altered_response_to1.72549311
33MP0003191_abnormal_cellular_cholesterol1.68041703
34MP0003075_altered_response_to1.62691185
35MP0002006_tumorigenesis1.58402043
36MP0008469_abnormal_protein_level1.56617843
37MP0004947_skin_inflammation1.55138190
38MP0002138_abnormal_hepatobiliary_system1.55012848
39MP0001533_abnormal_skeleton_physiology1.51187088
40MP0003300_gastrointestinal_ulcer1.49820295
41MP0005058_abnormal_lysosome_morphology1.49453897
42MP0000689_abnormal_spleen_morphology1.49292593
43MP0002429_abnormal_blood_cell1.44991027
44MP0002722_abnormal_immune_system1.41398102
45MP0001545_abnormal_hematopoietic_system1.40507288
46MP0005397_hematopoietic_system_phenotyp1.40507288
47MP0000858_altered_metastatic_potential1.38359979
48MP0006054_spinal_hemorrhage1.33268088
49MP0005166_decreased_susceptibility_to1.29845857
50MP0003656_abnormal_erythrocyte_physiolo1.26083862
51MP0009763_increased_sensitivity_to1.15638956
52MP0000465_gastrointestinal_hemorrhage1.15501992
53MP0005075_abnormal_melanosome_morpholog1.14452721
54MP0000372_irregular_coat_pigmentation1.14137409
55MP0005310_abnormal_salivary_gland1.12518208
56MP0003448_altered_tumor_morphology1.12047710
57MP0001873_stomach_inflammation1.10690432
58MP0003172_abnormal_lysosome_physiology1.10566691
59MP0004510_myositis1.10305472
60MP0005451_abnormal_body_composition1.10002909
61MP0009840_abnormal_foam_cell1.08736471
62MP0005165_increased_susceptibility_to1.03658262
63MP0002877_abnormal_melanocyte_morpholog1.02007227
64MP0003866_abnormal_defecation1.01908671
65MP0000703_abnormal_thymus_morphology1.01312159
66MP0003186_abnormal_redox_activity0.99484575
67MP0000569_abnormal_digit_pigmentation0.98054146
68MP0000015_abnormal_ear_pigmentation0.97017599
69MP0009278_abnormal_bone_marrow0.93439370
70MP0002132_abnormal_respiratory_system0.93097741
71MP0003195_calcinosis0.92912484
72MP0006036_abnormal_mitochondrial_physio0.91884504
73MP0002998_abnormal_bone_remodeling0.91573809
74MP0002277_abnormal_respiratory_mucosa0.91497688
75MP0005164_abnormal_response_to0.90768478
76MP0003950_abnormal_plasma_membrane0.88675573
77MP0002139_abnormal_hepatobiliary_system0.88554377
78MP0009765_abnormal_xenobiotic_induced0.84750913
79MP0003828_pulmonary_edema0.82277789
80MP0002019_abnormal_tumor_incidence0.82175615
81MP0008260_abnormal_autophagy0.81636228
82MP0005167_abnormal_blood-brain_barrier0.80444433
83MP0000371_diluted_coat_color0.78193015
84MP0005084_abnormal_gallbladder_morpholo0.76879673
85MP0004147_increased_porphyrin_level0.76839397
86MP0001851_eye_inflammation0.73789024
87MP0003183_abnormal_peptide_metabolism0.71457843
88MP0005408_hypopigmentation0.69404099
89MP0008873_increased_physiological_sensi0.69382045
90MP0002396_abnormal_hematopoietic_system0.68752686
91MP0002095_abnormal_skin_pigmentation0.68260233
92MP0000604_amyloidosis0.68219154
93MP0004883_abnormal_blood_vessel0.67775821
94MP0005174_abnormal_tail_pigmentation0.67241562
95MP0002332_abnormal_exercise_endurance0.66659281
96MP0000249_abnormal_blood_vessel0.64036043
97MP0008004_abnormal_stomach_pH0.63654157
98MP0001764_abnormal_homeostasis0.63300154
99MP0001663_abnormal_digestive_system0.63261537
100MP0004381_abnormal_hair_follicle0.62868337

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.13225914
2Recurrent bacterial skin infections (HP:0005406)4.02706131
3Recurrent abscess formation (HP:0002722)3.85324901
4Stomatitis (HP:0010280)3.85104847
5Abnormality of macrophages (HP:0004311)3.72058317
6Abnormality of T cell number (HP:0011839)3.69938133
7Increased IgM level (HP:0003496)3.69414620
8T lymphocytopenia (HP:0005403)3.68845917
9Abnormality of liposaccharide metabolism (HP:0010968)3.61174303
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.61174303
11Abnormality of glycolipid metabolism (HP:0010969)3.61174303
12Myositis (HP:0100614)3.60404717
13Retrobulbar optic neuritis (HP:0100654)3.52245398
14Optic neuritis (HP:0100653)3.52245398
15IgG deficiency (HP:0004315)3.50988063
16Autoimmune hemolytic anemia (HP:0001890)3.41008912
17Orchitis (HP:0100796)3.37634037
18Mediastinal lymphadenopathy (HP:0100721)3.29921968
19Vasculitis (HP:0002633)3.24097146
20Obstructive lung disease (HP:0006536)3.19309467
21Chronic obstructive pulmonary disease (HP:0006510)3.19309467
22IgM deficiency (HP:0002850)3.17891227
23Abnormality of T cells (HP:0002843)3.12722986
24Pulmonary infiltrates (HP:0002113)3.11680426
25Eczematoid dermatitis (HP:0000976)3.09695835
26Meningitis (HP:0001287)3.09469402
27Recurrent fungal infections (HP:0002841)3.05948648
28Recurrent cutaneous fungal infections (HP:0011370)3.05114727
29Chronic mucocutaneous candidiasis (HP:0002728)3.05114727
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.98085573
31Recurrent viral infections (HP:0004429)2.92509535
32Vacuolated lymphocytes (HP:0001922)2.91102979
33Autoimmune thrombocytopenia (HP:0001973)2.88714348
34Recurrent skin infections (HP:0001581)2.87644486
35Abnormality of the prostate (HP:0008775)2.85925013
36Abnormality of T cell physiology (HP:0011840)2.77626521
37Encephalitis (HP:0002383)2.76457147
38Abnormality of B cell number (HP:0010975)2.76310674
39B lymphocytopenia (HP:0010976)2.73868289
40Hepatosplenomegaly (HP:0001433)2.62552381
41Hemoptysis (HP:0002105)2.62251472
42Petechiae (HP:0000967)2.61298063
43Urticaria (HP:0001025)2.60990252
44IgA deficiency (HP:0002720)2.56677256
45Keratoconjunctivitis sicca (HP:0001097)2.56533306
46Gangrene (HP:0100758)2.53844678
47Chronic diarrhea (HP:0002028)2.53782692
48Recurrent bronchitis (HP:0002837)2.48839058
49Recurrent gram-negative bacterial infections (HP:0005420)2.48426553
50Eosinophilia (HP:0001880)2.45810430
51Mitochondrial inheritance (HP:0001427)2.42652671
52Granulocytopenia (HP:0001913)2.37784652
53Keratoconjunctivitis (HP:0001096)2.36188994
54Pulmonary fibrosis (HP:0002206)2.33806054
55Agammaglobulinemia (HP:0004432)2.32862093
56Hepatocellular necrosis (HP:0001404)2.30137023
57Acute necrotizing encephalopathy (HP:0006965)2.29346667
58Panhypogammaglobulinemia (HP:0003139)2.26508153
59Leukocytosis (HP:0001974)2.26236710
60Abnormal mitochondria in muscle tissue (HP:0008316)2.25913326
61Gastrointestinal infarctions (HP:0005244)2.24119795
62Abnormality of the pleura (HP:0002103)2.23468430
63Pustule (HP:0200039)2.22672020
64Exertional dyspnea (HP:0002875)2.21620921
65Increased intramyocellular lipid droplets (HP:0012240)2.21128235
66Anorexia (HP:0002039)2.21104120
67Severe combined immunodeficiency (HP:0004430)2.20681802
68Hypergammaglobulinemia (HP:0010702)2.20525238
69Abnormality of eosinophils (HP:0001879)2.19166212
70Increased CSF lactate (HP:0002490)2.18486485
71Acute hepatic failure (HP:0006554)2.16632458
72Skin rash (HP:0000988)2.16345044
73Combined immunodeficiency (HP:0005387)2.15028327
74Increased hepatocellular lipid droplets (HP:0006565)2.14915686
75Aplastic anemia (HP:0001915)2.12737602
76Chest pain (HP:0100749)2.10897522
77Prostate neoplasm (HP:0100787)2.10576686
78Joint swelling (HP:0001386)2.10484487
79Polyneuropathy (HP:0001271)2.07806725
80Hepatic necrosis (HP:0002605)2.06362484
81Lymphopenia (HP:0001888)2.05930206
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05693493
83Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05693493
84Gastrointestinal stroma tumor (HP:0100723)2.05504654
85Hypertensive crisis (HP:0100735)2.03843833
86Increased serum ferritin (HP:0003281)2.02577386
87Renal Fanconi syndrome (HP:0001994)2.01640898
883-Methylglutaconic aciduria (HP:0003535)2.01364754
89Nausea (HP:0002018)2.00077331
90Glomerulopathy (HP:0100820)1.99485683
91Amyloidosis (HP:0011034)1.99466038
92Abnormality of cells of the lymphoid lineage (HP:0012140)1.98735535
93Progressive macrocephaly (HP:0004481)1.96589278
94Albinism (HP:0001022)1.95482897
95Arterial thrombosis (HP:0004420)1.94950950
96Disinhibition (HP:0000734)1.93803271
97Lipid accumulation in hepatocytes (HP:0006561)1.93245675
98Hypoproteinemia (HP:0003075)1.93100230
99Increased cerebral lipofuscin (HP:0011813)1.92918589
100Systemic lupus erythematosus (HP:0002725)1.89881377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK42.90893714
2TXK2.87321250
3NME22.80715033
4BMPR22.66982222
5MST42.62860966
6MAP4K12.55837822
7MAP3K142.54878885
8MAP3K122.49014192
9TESK22.46940978
10EIF2AK32.37449872
11BLK2.27471160
12TAOK32.16460450
13IRAK32.15784601
14SIK32.14906895
15TBK12.04405763
16IKBKE2.01494451
17IKBKB1.99352266
18TYK21.89966291
19IRAK41.74421875
20CSK1.71156607
21BCKDK1.61558935
22SYK1.51978516
23GRK71.51777238
24TLK11.50562357
25MAP3K31.49007394
26MATK1.48995395
27KDR1.46968264
28JAK31.37357307
29PIM21.32348701
30PDK21.31922166
31ARAF1.31074607
32VRK21.26869961
33LYN1.22182549
34TEC1.20728679
35CSF1R1.19749756
36KIT1.16958531
37EIF2AK11.14878599
38JAK11.14606584
39BTK1.14124900
40VRK11.12016330
41ITK1.11624316
42TRIM281.11160214
43TESK11.07330840
44NUAK11.06209405
45ZAP701.04423942
46MARK31.04166844
47FGR1.01352146
48STK101.01036553
49NEK11.00272465
50LCK0.95350434
51BUB10.90486319
52FES0.90117996
53TAOK20.90054830
54MAP3K110.88803378
55GRK60.88131469
56CCNB10.87753973
57ERBB30.86949083
58ZAK0.85301403
59PRKCQ0.84154372
60PIM10.83576648
61MAP3K130.83378276
62SCYL20.81200507
63HCK0.79996700
64STK160.79840220
65MYLK0.79444537
66BCR0.78937131
67ADRBK20.75380820
68MAP2K30.75147947
69MOS0.73511329
70EIF2AK20.71263351
71MAP4K20.70190128
72TGFBR20.70081828
73TRPM70.69665948
74RPS6KA50.66544270
75TNK20.65846124
76LIMK10.65042142
77DAPK10.61328090
78ACVR1B0.60959501
79ERN10.59619666
80MAP3K50.59578540
81JAK20.59065218
82STK240.59035441
83NEK90.51842884
84MAPKAPK30.51614926
85ABL20.50679991
86MAPKAPK20.50317139
87CHUK0.48982065
88PIK3CG0.47951884
89ABL10.46172605
90OXSR10.45344036
91DAPK30.42343204
92PAK40.42218329
93IRAK10.38289617
94IGF1R0.35893890
95BMPR1B0.35452679
96PRKCD0.33061488
97LMTK20.32751328
98EGFR0.32694942
99CSNK1G30.31577844
100PAK10.28274302

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.94018886
2Asthma_Homo sapiens_hsa053103.88207795
3Graft-versus-host disease_Homo sapiens_hsa053323.77316488
4Autoimmune thyroid disease_Homo sapiens_hsa053203.60069529
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.21614877
6Proteasome_Homo sapiens_hsa030503.08523144
7Type I diabetes mellitus_Homo sapiens_hsa049402.90766703
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.73865723
9Primary immunodeficiency_Homo sapiens_hsa053402.63907619
10Antigen processing and presentation_Homo sapiens_hsa046122.58496550
11Staphylococcus aureus infection_Homo sapiens_hsa051502.47440412
12Rheumatoid arthritis_Homo sapiens_hsa053232.42869351
13Leishmaniasis_Homo sapiens_hsa051402.41143359
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17869630
15Viral myocarditis_Homo sapiens_hsa054162.05878650
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.97645650
17Hematopoietic cell lineage_Homo sapiens_hsa046401.82076564
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72022910
19Legionellosis_Homo sapiens_hsa051341.69994270
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69812116
21Tuberculosis_Homo sapiens_hsa051521.59102538
22Systemic lupus erythematosus_Homo sapiens_hsa053221.50625385
23Oxidative phosphorylation_Homo sapiens_hsa001901.50602051
24Herpes simplex infection_Homo sapiens_hsa051681.49024742
25Osteoclast differentiation_Homo sapiens_hsa043801.46974811
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42064960
27Measles_Homo sapiens_hsa051621.41501503
28Malaria_Homo sapiens_hsa051441.39499660
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36707961
30Influenza A_Homo sapiens_hsa051641.35535207
31Toxoplasmosis_Homo sapiens_hsa051451.23226651
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22095183
33Parkinsons disease_Homo sapiens_hsa050121.16725554
34Shigellosis_Homo sapiens_hsa051311.09848110
35Phagosome_Homo sapiens_hsa041451.06514569
36Salmonella infection_Homo sapiens_hsa051321.05746263
37Protein export_Homo sapiens_hsa030601.05682185
38TNF signaling pathway_Homo sapiens_hsa046681.05405800
39Pertussis_Homo sapiens_hsa051331.05186470
40Lysosome_Homo sapiens_hsa041420.99546351
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99428913
42Other glycan degradation_Homo sapiens_hsa005110.96301686
43African trypanosomiasis_Homo sapiens_hsa051430.94968575
44* Epstein-Barr virus infection_Homo sapiens_hsa051690.94545340
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92506987
46B cell receptor signaling pathway_Homo sapiens_hsa046620.88451782
47Homologous recombination_Homo sapiens_hsa034400.87682115
48T cell receptor signaling pathway_Homo sapiens_hsa046600.86972996
49Alzheimers disease_Homo sapiens_hsa050100.74598068
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.73304473
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71502513
52Apoptosis_Homo sapiens_hsa042100.70093700
53Ribosome_Homo sapiens_hsa030100.67008886
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66757118
55Mismatch repair_Homo sapiens_hsa034300.66342359
56Chemokine signaling pathway_Homo sapiens_hsa040620.66133301
57DNA replication_Homo sapiens_hsa030300.61708847
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61418031
59* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60850728
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59368758
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.57980067
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57143651
63Hepatitis B_Homo sapiens_hsa051610.55951615
64Nucleotide excision repair_Homo sapiens_hsa034200.55671635
65Huntingtons disease_Homo sapiens_hsa050160.54718278
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53762313
67RNA polymerase_Homo sapiens_hsa030200.51562303
68Pyrimidine metabolism_Homo sapiens_hsa002400.49823568
69Viral carcinogenesis_Homo sapiens_hsa052030.49411362
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.48551567
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48383589
72Collecting duct acid secretion_Homo sapiens_hsa049660.46102303
73Sulfur metabolism_Homo sapiens_hsa009200.45675733
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45397258
75HTLV-I infection_Homo sapiens_hsa051660.44677207
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43008830
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42418694
78Base excision repair_Homo sapiens_hsa034100.38738076
79Hepatitis C_Homo sapiens_hsa051600.35252229
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34480560
81p53 signaling pathway_Homo sapiens_hsa041150.32216562
82Regulation of autophagy_Homo sapiens_hsa041400.31628960
83RNA degradation_Homo sapiens_hsa030180.30867714
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30834443
85Glutathione metabolism_Homo sapiens_hsa004800.30060416
86Fatty acid elongation_Homo sapiens_hsa000620.29230246
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25770894
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25229938
89Pentose phosphate pathway_Homo sapiens_hsa000300.23662938
90Fanconi anemia pathway_Homo sapiens_hsa034600.21641038
91Galactose metabolism_Homo sapiens_hsa000520.21516357
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.19023211
93Folate biosynthesis_Homo sapiens_hsa007900.17184435
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.15532619
95Non-homologous end-joining_Homo sapiens_hsa034500.15175160
96Peroxisome_Homo sapiens_hsa041460.13822699
97Basal transcription factors_Homo sapiens_hsa030220.13572036
98Purine metabolism_Homo sapiens_hsa002300.13546639
99Platelet activation_Homo sapiens_hsa046110.13007131
100Mineral absorption_Homo sapiens_hsa049780.12364728

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