

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | omega-hydroxylase P450 pathway (GO:0097267) | 8.62120568 |
| 2 | epoxygenase P450 pathway (GO:0019373) | 8.38647745 |
| 3 | exogenous drug catabolic process (GO:0042738) | 8.16026400 |
| 4 | complement activation, alternative pathway (GO:0006957) | 7.49632114 |
| 5 | killing of cells of other organism (GO:0031640) | 6.39195946 |
| 6 | disruption of cells of other organism (GO:0044364) | 6.39195946 |
| 7 | L-phenylalanine catabolic process (GO:0006559) | 6.37375615 |
| 8 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 6.37375615 |
| 9 | disruption of cells of other organism involved in symbiotic interaction (GO:0051818) | 6.14757009 |
| 10 | killing of cells in other organism involved in symbiotic interaction (GO:0051883) | 6.14757009 |
| 11 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 6.14035819 |
| 12 | L-phenylalanine metabolic process (GO:0006558) | 6.12015171 |
| 13 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 6.12015171 |
| 14 | regulation of protein activation cascade (GO:2000257) | 6.11271402 |
| 15 | ethanol metabolic process (GO:0006067) | 6.10699430 |
| 16 | regulation of complement activation (GO:0030449) | 5.91527740 |
| 17 | peptidyl-glutamic acid carboxylation (GO:0017187) | 5.88076314 |
| 18 | protein carboxylation (GO:0018214) | 5.88076314 |
| 19 | aromatic amino acid family catabolic process (GO:0009074) | 5.66213167 |
| 20 | urea cycle (GO:0000050) | 5.44784879 |
| 21 | urea metabolic process (GO:0019627) | 5.44784879 |
| 22 | regulation of apoptotic cell clearance (GO:2000425) | 5.43670156 |
| 23 | drug metabolic process (GO:0017144) | 5.36838617 |
| 24 | regulation of plasminogen activation (GO:0010755) | 5.29498604 |
| 25 | negative regulation of fibrinolysis (GO:0051918) | 5.29442593 |
| 26 | alpha-linolenic acid metabolic process (GO:0036109) | 5.24701157 |
| 27 | high-density lipoprotein particle remodeling (GO:0034375) | 5.10003155 |
| 28 | complement activation (GO:0006956) | 5.04159000 |
| 29 | bile acid biosynthetic process (GO:0006699) | 5.03186980 |
| 30 | indolalkylamine catabolic process (GO:0046218) | 5.02025768 |
| 31 | tryptophan catabolic process (GO:0006569) | 5.02025768 |
| 32 | indole-containing compound catabolic process (GO:0042436) | 5.02025768 |
| 33 | nitrogen cycle metabolic process (GO:0071941) | 4.97610213 |
| 34 | regulation of fibrinolysis (GO:0051917) | 4.97558919 |
| 35 | kynurenine metabolic process (GO:0070189) | 4.97527229 |
| 36 | glyoxylate metabolic process (GO:0046487) | 4.97167458 |
| 37 | opsonization (GO:0008228) | 4.81761371 |
| 38 | plasma lipoprotein particle clearance (GO:0034381) | 4.80534251 |
| 39 | phospholipid efflux (GO:0033700) | 4.76744414 |
| 40 | tryptophan metabolic process (GO:0006568) | 4.76369569 |
| 41 | antibacterial humoral response (GO:0019731) | 4.74798809 |
| 42 | reverse cholesterol transport (GO:0043691) | 4.70842187 |
| 43 | oxidative demethylation (GO:0070989) | 4.66895366 |
| 44 | defense response to fungus (GO:0050832) | 4.66379620 |
| 45 | regulation of cholesterol esterification (GO:0010872) | 4.65855005 |
| 46 | complement activation, classical pathway (GO:0006958) | 4.60741054 |
| 47 | sulfur amino acid catabolic process (GO:0000098) | 4.58557790 |
| 48 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.57333265 |
| 49 | protein activation cascade (GO:0072376) | 4.53988944 |
| 50 | cysteine metabolic process (GO:0006534) | 4.45017372 |
| 51 | protein-lipid complex remodeling (GO:0034368) | 4.44535677 |
| 52 | macromolecular complex remodeling (GO:0034367) | 4.44535677 |
| 53 | plasma lipoprotein particle remodeling (GO:0034369) | 4.44535677 |
| 54 | antimicrobial humoral response (GO:0019730) | 4.38972704 |
| 55 | bile acid metabolic process (GO:0008206) | 4.36602043 |
| 56 | regulation of triglyceride catabolic process (GO:0010896) | 4.35008352 |
| 57 | negative regulation of sterol transport (GO:0032372) | 4.27420670 |
| 58 | negative regulation of cholesterol transport (GO:0032375) | 4.27420670 |
| 59 | cholesterol efflux (GO:0033344) | 4.27291443 |
| 60 | detection of bacterium (GO:0016045) | 4.24022496 |
| 61 | serine family amino acid catabolic process (GO:0009071) | 4.20225226 |
| 62 | protoporphyrinogen IX metabolic process (GO:0046501) | 4.10288505 |
| 63 | plasma lipoprotein particle assembly (GO:0034377) | 4.09264076 |
| 64 | cytolysis (GO:0019835) | 4.05816766 |
| 65 | aromatic amino acid family metabolic process (GO:0009072) | 4.05228969 |
| 66 | negative regulation of hemostasis (GO:1900047) | 4.04930662 |
| 67 | negative regulation of blood coagulation (GO:0030195) | 4.04930662 |
| 68 | tyrosine metabolic process (GO:0006570) | 4.04449905 |
| 69 | fibrinolysis (GO:0042730) | 4.04170907 |
| 70 | regulation of humoral immune response (GO:0002920) | 4.03828346 |
| 71 | triglyceride homeostasis (GO:0070328) | 4.02594441 |
| 72 | acylglycerol homeostasis (GO:0055090) | 4.02594441 |
| 73 | hemoglobin metabolic process (GO:0020027) | 3.98347413 |
| 74 | amino-acid betaine metabolic process (GO:0006577) | 3.97466182 |
| 75 | homocysteine metabolic process (GO:0050667) | 3.97218010 |
| 76 | detection of other organism (GO:0098543) | 3.94529636 |
| 77 | protoporphyrinogen IX biosynthetic process (GO:0006782) | 3.92799295 |
| 78 | innate immune response in mucosa (GO:0002227) | 3.89283715 |
| 79 | low-density lipoprotein particle remodeling (GO:0034374) | 3.87822701 |
| 80 | alpha-amino acid catabolic process (GO:1901606) | 3.86483941 |
| 81 | hyaluronan catabolic process (GO:0030214) | 3.86342238 |
| 82 | lysine catabolic process (GO:0006554) | 3.82260431 |
| 83 | lysine metabolic process (GO:0006553) | 3.82260431 |
| 84 | phenylpropanoid metabolic process (GO:0009698) | 3.80649313 |
| 85 | protein-lipid complex assembly (GO:0065005) | 3.80249965 |
| 86 | bile acid and bile salt transport (GO:0015721) | 3.78027767 |
| 87 | uronic acid metabolic process (GO:0006063) | 3.77673323 |
| 88 | glucuronate metabolic process (GO:0019585) | 3.77673323 |
| 89 | negative regulation of protein activation cascade (GO:2000258) | 3.74907760 |
| 90 | ethanol oxidation (GO:0006069) | 3.70877269 |
| 91 | imidazole-containing compound metabolic process (GO:0052803) | 3.70588865 |
| 92 | cellular ketone body metabolic process (GO:0046950) | 3.67845768 |
| 93 | phospholipid homeostasis (GO:0055091) | 3.67714556 |
| 94 | negative regulation of coagulation (GO:0050819) | 3.65667894 |
| 95 | S-adenosylmethionine metabolic process (GO:0046500) | 3.64447039 |
| 96 | arginine metabolic process (GO:0006525) | 3.64439225 |
| 97 | aldehyde catabolic process (GO:0046185) | 3.62297165 |
| 98 | glutamate metabolic process (GO:0006536) | 3.59480523 |
| 99 | plasma lipoprotein particle organization (GO:0071827) | 3.57594593 |
| 100 | positive regulation of blood coagulation (GO:0030194) | 3.57310753 |
| 101 | positive regulation of hemostasis (GO:1900048) | 3.57310753 |
| 102 | porphyrin-containing compound metabolic process (GO:0006778) | 3.56533253 |
| 103 | acute-phase response (GO:0006953) | 3.55091802 |
| 104 | blood coagulation, intrinsic pathway (GO:0007597) | 3.54439262 |
| 105 | cellular amino acid catabolic process (GO:0009063) | 3.53030687 |
| 106 | cholesterol homeostasis (GO:0042632) | 3.52486004 |
| 107 | glycine metabolic process (GO:0006544) | 3.52160034 |
| 108 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.51947721 |
| 109 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.51947721 |
| 110 | indolalkylamine metabolic process (GO:0006586) | 3.50071489 |
| 111 | positive regulation of lipid catabolic process (GO:0050996) | 3.49851818 |
| 112 | negative regulation of wound healing (GO:0061045) | 3.49303517 |
| 113 | oxygen transport (GO:0015671) | 3.49254894 |
| 114 | positive regulation of coagulation (GO:0050820) | 3.48875831 |
| 115 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.48556229 |
| 116 | sterol homeostasis (GO:0055092) | 3.47427025 |
| 117 | apoptotic cell clearance (GO:0043277) | 3.47390534 |
| 118 | lipoprotein metabolic process (GO:0042157) | 3.46754207 |
| 119 | cellular glucuronidation (GO:0052695) | 3.46173324 |
| 120 | cellular modified amino acid catabolic process (GO:0042219) | 3.44679120 |
| 121 | coenzyme catabolic process (GO:0009109) | 3.44173467 |
| 122 | protein-lipid complex subunit organization (GO:0071825) | 3.44081204 |
| 123 | humoral immune response (GO:0006959) | 3.44077838 |
| 124 | heme metabolic process (GO:0042168) | 3.41412267 |
| 125 | cellular biogenic amine catabolic process (GO:0042402) | 3.37347066 |
| 126 | amine catabolic process (GO:0009310) | 3.37347066 |
| 127 | benzene-containing compound metabolic process (GO:0042537) | 3.37286492 |
| 128 | cofactor catabolic process (GO:0051187) | 3.36382938 |
| 129 | alkaloid metabolic process (GO:0009820) | 3.34709361 |
| 130 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.30750137 |
| 131 | serine family amino acid metabolic process (GO:0009069) | 3.29362847 |
| 132 | mannose metabolic process (GO:0006013) | 3.29091380 |
| 133 | regulation of cholesterol homeostasis (GO:2000188) | 3.27773396 |
| 134 | negative regulation of lipase activity (GO:0060192) | 3.23620247 |
| 135 | drug catabolic process (GO:0042737) | 3.22444951 |
| 136 | citrulline biosynthetic process (GO:0019240) | 3.21645950 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 7.37211330 |
| 2 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 6.34030323 |
| 3 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 5.72962052 |
| 4 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 5.71581352 |
| 5 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 4.48339033 |
| 6 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.28528993 |
| 7 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 4.18421480 |
| 8 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.52728659 |
| 9 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 3.33435242 |
| 10 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.62298740 |
| 11 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.55483269 |
| 12 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.26707333 |
| 13 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.14116355 |
| 14 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.00442841 |
| 15 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 10.4200844 |
| 16 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.90804716 |
| 17 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.88032192 |
| 18 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.85461000 |
| 19 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.85111872 |
| 20 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.80279908 |
| 21 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.70547703 |
| 22 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.67654614 |
| 23 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.64268929 |
| 24 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.63856545 |
| 25 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.59494309 |
| 26 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.59368342 |
| 27 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.51777715 |
| 28 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.51574774 |
| 29 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.50747982 |
| 30 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.49359709 |
| 31 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.43144383 |
| 32 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.40629671 |
| 33 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.40243800 |
| 34 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.39567509 |
| 35 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.37407490 |
| 36 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.33446002 |
| 37 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.29466586 |
| 38 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.28010467 |
| 39 | GATA1_22025678_ChIP-Seq_K562_Human | 1.27910712 |
| 40 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.22506035 |
| 41 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.20236821 |
| 42 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.19770097 |
| 43 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.16680894 |
| 44 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.13545748 |
| 45 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.10028267 |
| 46 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.09248375 |
| 47 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.09001354 |
| 48 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.05027903 |
| 49 | P68_20966046_ChIP-Seq_HELA_Human | 1.04754667 |
| 50 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 1.04045571 |
| 51 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.02566858 |
| 52 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.99283431 |
| 53 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.99004773 |
| 54 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.98985647 |
| 55 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.98079424 |
| 56 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.98074875 |
| 57 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.96236931 |
| 58 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.95283373 |
| 59 | * RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.95132448 |
| 60 | GATA1_19941826_ChIP-Seq_K562_Human | 0.95037783 |
| 61 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.94139014 |
| 62 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.93658446 |
| 63 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.92959503 |
| 64 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.92118034 |
| 65 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.91869385 |
| 66 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.91279224 |
| 67 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.90417230 |
| 68 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.90185551 |
| 69 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89935073 |
| 70 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.89670401 |
| 71 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.89431267 |
| 72 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.89431267 |
| 73 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.89431267 |
| 74 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.88997095 |
| 75 | GATA2_19941826_ChIP-Seq_K562_Human | 0.88738225 |
| 76 | * RAC3_21632823_ChIP-Seq_H3396_Human | 0.87652835 |
| 77 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.87629210 |
| 78 | * BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.87534348 |
| 79 | UTX_26944678_Chip-Seq_JUKART_Human | 0.87089777 |
| 80 | P300_27268052_Chip-Seq_Bcells_Human | 0.86166718 |
| 81 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.83855523 |
| 82 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.83758350 |
| 83 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.83717299 |
| 84 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.83626081 |
| 85 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.82318938 |
| 86 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.81633903 |
| 87 | SA1_27219007_Chip-Seq_Bcells_Human | 0.81527916 |
| 88 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.79390173 |
| 89 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.78790707 |
| 90 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.78551119 |
| 91 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.78462760 |
| 92 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.77939438 |
| 93 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.77852319 |
| 94 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.77179244 |
| 95 | * ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.77135862 |
| 96 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.74806053 |
| 97 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.74754951 |
| 98 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.74698668 |
| 99 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.73843065 |
| 100 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.72438199 |
| 101 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.72195362 |
| 102 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.71418372 |
| 103 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.70580306 |
| 104 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.70118293 |
| 105 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.69863823 |
| 106 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.69863823 |
| 107 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.69602032 |
| 108 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.68942352 |
| 109 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.68499176 |
| 110 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.67159943 |
| 111 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.66183385 |
| 112 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.65994470 |
| 113 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.64962367 |
| 114 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.64960866 |
| 115 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.64719626 |
| 116 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.64312156 |
| 117 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.63933356 |
| 118 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.62700130 |
| 119 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.62055480 |
| 120 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.61970948 |
| 121 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.61568521 |
| 122 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.60600849 |
| 123 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.60566889 |
| 124 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.59245233 |
| 125 | RUNX_20019798_ChIP-Seq_JUKART_Human | 0.57870293 |
| 126 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.57371250 |
| 127 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.57274536 |
| 128 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.56556130 |
| 129 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.56251677 |
| 130 | SPI1_23127762_ChIP-Seq_K562_Human | 0.56143536 |
| 131 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.55668884 |
| 132 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.55111862 |
| 133 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.55035390 |
| 134 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.54918240 |
| 135 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.54617543 |
| 136 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.54589269 |
| 137 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.53722883 |
| 138 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.53249981 |
| 139 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.52972763 |
| 140 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.52528056 |
| 141 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.51983027 |
| 142 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.51900288 |
| 143 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.51252919 |
| 144 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.51048390 |
| 145 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.50298020 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002139_abnormal_hepatobiliary_system | 6.94451890 |
| 2 | MP0005360_urolithiasis | 6.47080982 |
| 3 | MP0005085_abnormal_gallbladder_physiolo | 5.26288902 |
| 4 | MP0005365_abnormal_bile_salt | 5.24472046 |
| 5 | MP0008875_abnormal_xenobiotic_pharmacok | 4.34525242 |
| 6 | MP0009840_abnormal_foam_cell | 4.12907538 |
| 7 | MP0010329_abnormal_lipoprotein_level | 3.35189902 |
| 8 | MP0003252_abnormal_bile_duct | 3.21528312 |
| 9 | MP0003806_abnormal_nucleotide_metabolis | 3.19533292 |
| 10 | MP0005083_abnormal_biliary_tract | 3.02491729 |
| 11 | MP0004147_increased_porphyrin_level | 2.99863627 |
| 12 | MP0003191_abnormal_cellular_cholesterol | 2.86477056 |
| 13 | MP0005332_abnormal_amino_acid | 2.43830851 |
| 14 | MP0003195_calcinosis | 2.36648466 |
| 15 | MP0002138_abnormal_hepatobiliary_system | 2.27840204 |
| 16 | MP0001666_abnormal_nutrient_absorption | 2.16383354 |
| 17 | MP0000609_abnormal_liver_physiology | 2.12703924 |
| 18 | MP0003705_abnormal_hypodermis_morpholog | 2.05093305 |
| 19 | MP0005058_abnormal_lysosome_morphology | 2.04959131 |
| 20 | MP0002118_abnormal_lipid_homeostasis | 1.94251956 |
| 21 | MP0004019_abnormal_vitamin_homeostasis | 1.92727211 |
| 22 | MP0003436_decreased_susceptibility_to | 1.92573805 |
| 23 | MP0000604_amyloidosis | 1.76546457 |
| 24 | MP0003656_abnormal_erythrocyte_physiolo | 1.75014822 |
| 25 | MP0005319_abnormal_enzyme/_coenzyme | 1.72308523 |
| 26 | MP0002132_abnormal_respiratory_system | 1.71138052 |
| 27 | MP0001545_abnormal_hematopoietic_system | 1.61899216 |
| 28 | MP0005397_hematopoietic_system_phenotyp | 1.61899216 |
| 29 | MP0009333_abnormal_splenocyte_physiolog | 1.57496982 |
| 30 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.47869333 |
| 31 | MP0005464_abnormal_platelet_physiology | 1.42804776 |
| 32 | MP0003868_abnormal_feces_composition | 1.41498741 |
| 33 | MP0001764_abnormal_homeostasis | 1.41136360 |
| 34 | MP0003724_increased_susceptibility_to | 1.34690267 |
| 35 | MP0009763_increased_sensitivity_to | 1.33060048 |
| 36 | MP0003075_altered_response_to | 1.29682270 |
| 37 | MP0003011_delayed_dark_adaptation | 1.28450271 |
| 38 | MP0003303_peritoneal_inflammation | 1.27594949 |
| 39 | MP0005451_abnormal_body_composition | 1.27230178 |
| 40 | MP0003690_abnormal_glial_cell | 1.26416915 |
| 41 | MP0000598_abnormal_liver_morphology | 1.26200415 |
| 42 | MP0008469_abnormal_protein_level | 1.26044621 |
| 43 | MP0002254_reproductive_system_inflammat | 1.25831894 |
| 44 | MP0002419_abnormal_innate_immunity | 1.22062024 |
| 45 | MP0001790_abnormal_immune_system | 1.20388787 |
| 46 | MP0005387_immune_system_phenotype | 1.20388787 |
| 47 | MP0009643_abnormal_urine_homeostasis | 1.18879748 |
| 48 | MP0010368_abnormal_lymphatic_system | 1.16970167 |
| 49 | MP0000685_abnormal_immune_system | 1.10443939 |
| 50 | MP0006082_CNS_inflammation | 1.07747995 |
| 51 | MP0009764_decreased_sensitivity_to | 1.07374858 |
| 52 | MP0001533_abnormal_skeleton_physiology | 1.04249925 |
| 53 | * MP0005025_abnormal_response_to | 1.03600041 |
| 54 | MP0008438_abnormal_cutaneous_collagen | 1.02792152 |
| 55 | MP0003186_abnormal_redox_activity | 1.01622211 |
| 56 | MP0009697_abnormal_copulation | 1.01571566 |
| 57 | MP0001661_extended_life_span | 1.00167334 |
| 58 | MP0004947_skin_inflammation | 0.99878570 |
| 59 | MP0004883_abnormal_blood_vessel | 0.95501242 |
| 60 | MP0002876_abnormal_thyroid_physiology | 0.94456688 |
| 61 | MP0009642_abnormal_blood_homeostasis | 0.92017367 |
| 62 | MP0001835_abnormal_antigen_presentation | 0.89700850 |
| 63 | MP0005670_abnormal_white_adipose | 0.88564203 |
| 64 | MP0003300_gastrointestinal_ulcer | 0.88492940 |
| 65 | MP0001845_abnormal_inflammatory_respons | 0.88353944 |
| 66 | MP0000465_gastrointestinal_hemorrhage | 0.86741935 |
| 67 | MP0003172_abnormal_lysosome_physiology | 0.85442295 |
| 68 | MP0002332_abnormal_exercise_endurance | 0.81247030 |
| 69 | MP0004130_abnormal_muscle_cell | 0.81208414 |
| 70 | MP0005166_decreased_susceptibility_to | 0.80147928 |
| 71 | MP0001800_abnormal_humoral_immune | 0.78340605 |
| 72 | MP0005164_abnormal_response_to | 0.77960241 |
| 73 | MP0008872_abnormal_physiological_respon | 0.77932590 |
| 74 | MP0003329_amyloid_beta_deposits | 0.77249564 |
| 75 | MP0000249_abnormal_blood_vessel | 0.76559388 |
| 76 | MP0005000_abnormal_immune_tolerance | 0.75543484 |
| 77 | MP0002971_abnormal_brown_adipose | 0.74695698 |
| 78 | MP0009278_abnormal_bone_marrow | 0.74421506 |
| 79 | MP0002722_abnormal_immune_system | 0.74405201 |
| 80 | MP0000343_altered_response_to | 0.74159317 |
| 81 | MP0009785_altered_susceptibility_to | 0.71307975 |
| 82 | MP0002136_abnormal_kidney_physiology | 0.70588639 |
| 83 | MP0005636_abnormal_mineral_homeostasis | 0.67510059 |
| 84 | MP0005408_hypopigmentation | 0.67416188 |
| 85 | MP0009765_abnormal_xenobiotic_induced | 0.67367584 |
| 86 | MP0005647_abnormal_sex_gland | 0.67235860 |
| 87 | MP0002420_abnormal_adaptive_immunity | 0.67101764 |
| 88 | MP0001756_abnormal_urination | 0.66896033 |
| 89 | MP0001819_abnormal_immune_cell | 0.66189527 |
| 90 | MP0002078_abnormal_glucose_homeostasis | 0.66005864 |
| 91 | MP0005023_abnormal_wound_healing | 0.65881409 |
| 92 | MP0009053_abnormal_anal_canal | 0.65828496 |
| 93 | MP0005334_abnormal_fat_pad | 0.64288420 |
| 94 | MP0005266_abnormal_metabolism | 0.63753425 |
| 95 | MP0005376_homeostasis/metabolism_phenot | 0.63709403 |
| 96 | MP0002405_respiratory_system_inflammati | 0.63041594 |
| 97 | MP0003638_abnormal_response/metabolism_ | 0.62046956 |
| 98 | MP0005535_abnormal_body_temperature | 0.61719062 |
| 99 | MP0002168_other_aberrant_phenotype | 0.61662261 |
| 100 | MP0002452_abnormal_antigen_presenting | 0.60934114 |
| 101 | MP0001986_abnormal_taste_sensitivity | 0.60908015 |
| 102 | MP0003566_abnormal_cell_adhesion | 0.60876663 |
| 103 | MP0005167_abnormal_blood-brain_barrier | 0.59562521 |
| 104 | MP0010155_abnormal_intestine_physiology | 0.58932682 |
| 105 | MP0001915_intracranial_hemorrhage | 0.58797327 |
| 106 | * MP0002398_abnormal_bone_marrow | 0.58306722 |
| 107 | MP0005220_abnormal_exocrine_pancreas | 0.57746840 |
| 108 | MP0000858_altered_metastatic_potential | 0.56123181 |
| 109 | MP0006036_abnormal_mitochondrial_physio | 0.55929208 |
| 110 | MP0003879_abnormal_hair_cell | 0.55866138 |
| 111 | MP0005448_abnormal_energy_balance | 0.55646140 |
| 112 | MP0008873_increased_physiological_sensi | 0.55078679 |
| 113 | MP0002723_abnormal_immune_serum | 0.52549143 |
| 114 | MP0001853_heart_inflammation | 0.52392157 |
| 115 | MP0002166_altered_tumor_susceptibility | 0.51374181 |
| 116 | MP0005395_other_phenotype | 0.51046331 |
| 117 | MP0002148_abnormal_hypersensitivity_rea | 0.50838465 |
| 118 | MP0000767_abnormal_smooth_muscle | 0.48898974 |
| 119 | MP0001851_eye_inflammation | 0.48782152 |
| 120 | MP0002135_abnormal_kidney_morphology | 0.47910945 |
| 121 | MP0008874_decreased_physiological_sensi | 0.47460383 |
| 122 | MP0000689_abnormal_spleen_morphology | 0.47029858 |
| 123 | MP0002928_abnormal_bile_duct | 0.46023479 |
| 124 | MP0000639_abnormal_adrenal_gland | 0.45968129 |
| 125 | MP0004782_abnormal_surfactant_physiolog | 0.45950199 |
| 126 | MP0004510_myositis | 0.44553339 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Systemic lupus erythematosus (HP:0002725) | 7.44433347 |
| 2 | Deep venous thrombosis (HP:0002625) | 7.26410373 |
| 3 | Complement deficiency (HP:0004431) | 7.07348056 |
| 4 | Prolonged partial thromboplastin time (HP:0003645) | 6.24760990 |
| 5 | Abnormality of complement system (HP:0005339) | 5.99317043 |
| 6 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 5.79328397 |
| 7 | Intrahepatic cholestasis (HP:0001406) | 5.68430539 |
| 8 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 5.66383060 |
| 9 | Xanthomatosis (HP:0000991) | 5.60655244 |
| 10 | Glomerulonephritis (HP:0000099) | 5.49438267 |
| 11 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 5.08399027 |
| 12 | Hypobetalipoproteinemia (HP:0003563) | 5.00812390 |
| 13 | Joint hemorrhage (HP:0005261) | 4.93552208 |
| 14 | Abnormality of the common coagulation pathway (HP:0010990) | 4.68796781 |
| 15 | Hyperlipoproteinemia (HP:0010980) | 4.68642475 |
| 16 | Recurrent gram-negative bacterial infections (HP:0005420) | 4.17192894 |
| 17 | Poikilocytosis (HP:0004447) | 4.09519686 |
| 18 | Hypolipoproteinemia (HP:0010981) | 3.99328033 |
| 19 | Hypochromic anemia (HP:0001931) | 3.75151716 |
| 20 | Hypoalphalipoproteinemia (HP:0003233) | 3.73310570 |
| 21 | Hyperammonemia (HP:0001987) | 3.72876780 |
| 22 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 3.71521040 |
| 23 | Epidermoid cyst (HP:0200040) | 3.67290366 |
| 24 | Microcytic anemia (HP:0001935) | 3.51936583 |
| 25 | Nephritis (HP:0000123) | 3.45723498 |
| 26 | Hypercholesterolemia (HP:0003124) | 3.43706973 |
| 27 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 3.37479377 |
| 28 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.31307022 |
| 29 | Myocardial infarction (HP:0001658) | 3.27802760 |
| 30 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.25511146 |
| 31 | Cerebral palsy (HP:0100021) | 3.24456664 |
| 32 | Ketosis (HP:0001946) | 3.21908452 |
| 33 | Fat malabsorption (HP:0002630) | 3.20666140 |
| 34 | Purpura (HP:0000979) | 3.19976056 |
| 35 | Abnormality of methionine metabolism (HP:0010901) | 3.19300007 |
| 36 | Polycythemia (HP:0001901) | 3.16856014 |
| 37 | Abnormality of the intrinsic pathway (HP:0010989) | 3.16732205 |
| 38 | Hyperglycinemia (HP:0002154) | 3.11210936 |
| 39 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 3.06171034 |
| 40 | Menorrhagia (HP:0000132) | 2.99336335 |
| 41 | Hypoglycemic coma (HP:0001325) | 2.94344687 |
| 42 | Vacuolated lymphocytes (HP:0001922) | 2.86622879 |
| 43 | Conjugated hyperbilirubinemia (HP:0002908) | 2.80720637 |
| 44 | Hyperglycinuria (HP:0003108) | 2.75873595 |
| 45 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.75685729 |
| 46 | Abnormality of glycine metabolism (HP:0010895) | 2.75685729 |
| 47 | Mitral stenosis (HP:0001718) | 2.73871878 |
| 48 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.70025030 |
| 49 | Esophageal varix (HP:0002040) | 2.69766136 |
| 50 | Reticulocytosis (HP:0001923) | 2.68729405 |
| 51 | Spontaneous hematomas (HP:0007420) | 2.67908086 |
| 52 | Hyperbilirubinemia (HP:0002904) | 2.63718016 |
| 53 | Dysostosis multiplex (HP:0000943) | 2.63177917 |
| 54 | Gingival bleeding (HP:0000225) | 2.61990177 |
| 55 | Abnormality of nucleobase metabolism (HP:0010932) | 2.61879046 |
| 56 | Amyloidosis (HP:0011034) | 2.59294023 |
| 57 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.58695499 |
| 58 | Skin nodule (HP:0200036) | 2.55704143 |
| 59 | Neonatal hypoglycemia (HP:0001998) | 2.53365969 |
| 60 | Hepatocellular carcinoma (HP:0001402) | 2.49114962 |
| 61 | Mucopolysacchariduria (HP:0008155) | 2.45004855 |
| 62 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.45004855 |
| 63 | Spontaneous abortion (HP:0005268) | 2.44703808 |
| 64 | Meningitis (HP:0001287) | 2.43224229 |
| 65 | Chronic obstructive pulmonary disease (HP:0006510) | 2.41226665 |
| 66 | Obstructive lung disease (HP:0006536) | 2.41226665 |
| 67 | Steatorrhea (HP:0002570) | 2.38931377 |
| 68 | Osteomalacia (HP:0002749) | 2.36252803 |
| 69 | Recurrent abscess formation (HP:0002722) | 2.35972161 |
| 70 | Hypochromic microcytic anemia (HP:0004840) | 2.33830690 |
| 71 | Peritonitis (HP:0002586) | 2.31119385 |
| 72 | Abnormal hemoglobin (HP:0011902) | 2.29732669 |
| 73 | Abnormality of purine metabolism (HP:0004352) | 2.27165058 |
| 74 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.27038349 |
| 75 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.27038349 |
| 76 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.27038349 |
| 77 | Delayed CNS myelination (HP:0002188) | 2.26478592 |
| 78 | Azoospermia (HP:0000027) | 2.23391139 |
| 79 | Paralysis (HP:0003470) | 2.18464855 |
| 80 | Prolonged bleeding time (HP:0003010) | 2.18440195 |
| 81 | Abnormal platelet volume (HP:0011876) | 2.16398444 |
| 82 | Thrombophlebitis (HP:0004418) | 2.15554956 |
| 83 | Vascular calcification (HP:0004934) | 2.14336815 |
| 84 | Ketoacidosis (HP:0001993) | 2.13732184 |
| 85 | Abnormality of the gallbladder (HP:0005264) | 2.13668924 |
| 86 | Spastic diplegia (HP:0001264) | 2.12089471 |
| 87 | Arthropathy (HP:0003040) | 2.10916730 |
| 88 | Acanthocytosis (HP:0001927) | 2.07359750 |
| 89 | Abnormal gallbladder morphology (HP:0012437) | 2.07202664 |
| 90 | Cholelithiasis (HP:0001081) | 2.06448435 |
| 91 | Increased mean platelet volume (HP:0011877) | 2.05206288 |
| 92 | Loss of speech (HP:0002371) | 2.04421053 |
| 93 | Abnormal gallbladder physiology (HP:0012438) | 2.04200863 |
| 94 | Cholecystitis (HP:0001082) | 2.04200863 |
| 95 | Generalized aminoaciduria (HP:0002909) | 2.04160359 |
| 96 | Pulmonary embolism (HP:0002204) | 2.01763956 |
| 97 | Abnormality of serum amino acid levels (HP:0003112) | 2.01639725 |
| 98 | Abnormality of iron homeostasis (HP:0011031) | 2.01239922 |
| 99 | Hemorrhage of the eye (HP:0011885) | 1.99852591 |
| 100 | Irritability (HP:0000737) | 1.99823342 |
| 101 | Asymmetric septal hypertrophy (HP:0001670) | 1.99599463 |
| 102 | Epistaxis (HP:0000421) | 1.98770353 |
| 103 | Fair hair (HP:0002286) | 1.93681518 |
| 104 | Sensorimotor neuropathy (HP:0007141) | 1.93453992 |
| 105 | Metabolic acidosis (HP:0001942) | 1.92978165 |
| 106 | Cardiovascular calcification (HP:0011915) | 1.92248382 |
| 107 | Impaired platelet aggregation (HP:0003540) | 1.92178542 |
| 108 | Abnormal platelet function (HP:0011869) | 1.92178542 |
| 109 | Axonal loss (HP:0003447) | 1.91979759 |
| 110 | Upper motor neuron abnormality (HP:0002127) | 1.88967983 |
| 111 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.87688743 |
| 112 | Turricephaly (HP:0000262) | 1.87236986 |
| 113 | Abnormality of the lumbar spine (HP:0100712) | 1.86141632 |
| 114 | Gonadal dysgenesis (HP:0000133) | 1.85024402 |
| 115 | Pustule (HP:0200039) | 1.84983518 |
| 116 | Thoracic kyphosis (HP:0002942) | 1.84133696 |
| 117 | Diaphragmatic weakness (HP:0009113) | 1.83379115 |
| 118 | Joint swelling (HP:0001386) | 1.83194029 |
| 119 | Eczematoid dermatitis (HP:0000976) | 1.82715918 |
| 120 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.82697911 |
| 121 | Dicarboxylic aciduria (HP:0003215) | 1.82697911 |
| 122 | Toxemia of pregnancy (HP:0100603) | 1.82153584 |
| 123 | Hypoglycemic seizures (HP:0002173) | 1.81612492 |
| 124 | Global brain atrophy (HP:0002283) | 1.76997920 |
| 125 | Rickets (HP:0002748) | 1.74740108 |
| 126 | Hemoptysis (HP:0002105) | 1.74023807 |
| 127 | Late onset (HP:0003584) | 1.73993088 |
| 128 | Gastrointestinal infarctions (HP:0005244) | 1.73909737 |
| 129 | Increased serum ferritin (HP:0003281) | 1.73734174 |
| 130 | Recurrent bacterial skin infections (HP:0005406) | 1.73250404 |
| 131 | Neonatal onset (HP:0003623) | 1.72726654 |
| 132 | Acute hepatic failure (HP:0006554) | 1.72348177 |
| 133 | Hypertriglyceridemia (HP:0002155) | 1.69609335 |
| 134 | Abnormality of reticulocytes (HP:0004312) | 1.69052061 |
| 135 | Testicular neoplasm (HP:0010788) | 1.66955362 |
| 136 | Ileus (HP:0002595) | 1.65743593 |
| 137 | Vasculitis (HP:0002633) | 1.65734050 |
| 138 | Hematuria (HP:0000790) | 1.65447469 |
| 139 | Gangrene (HP:0100758) | 1.62227321 |
| 140 | Gingivitis (HP:0000230) | 1.60396718 |
| 141 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.60388115 |
| 142 | Myositis (HP:0100614) | 1.59561988 |
| 143 | Elevated alkaline phosphatase (HP:0003155) | 1.58794010 |
| 144 | Anorexia (HP:0002039) | 1.56989106 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ERN1 | 4.74749533 |
| 2 | MST1R | 4.68370208 |
| 3 | BCKDK | 3.65992533 |
| 4 | TAOK3 | 3.20091761 |
| 5 | PRPF4B | 3.06792668 |
| 6 | TRIB3 | 3.06764608 |
| 7 | PKN2 | 3.04285897 |
| 8 | FGFR4 | 3.01010000 |
| 9 | SIK1 | 2.74563221 |
| 10 | BLK | 2.69803374 |
| 11 | TNK2 | 2.58078374 |
| 12 | CAMK1D | 2.51699559 |
| 13 | TYK2 | 2.39271426 |
| 14 | TAOK2 | 2.35927289 |
| 15 | DAPK2 | 2.25897926 |
| 16 | TAOK1 | 2.18555538 |
| 17 | MAP4K1 | 2.13423692 |
| 18 | RIPK1 | 2.04305278 |
| 19 | PTK2B | 1.85314060 |
| 20 | GRK6 | 1.84630147 |
| 21 | MET | 1.79123169 |
| 22 | CAMK1G | 1.78937330 |
| 23 | PTK6 | 1.76302726 |
| 24 | TBK1 | 1.70175606 |
| 25 | EPHB1 | 1.65936003 |
| 26 | INSRR | 1.48894756 |
| 27 | KIT | 1.46584415 |
| 28 | TGFBR2 | 1.42251269 |
| 29 | MAP2K3 | 1.42125405 |
| 30 | BMX | 1.40612055 |
| 31 | TEC | 1.36577457 |
| 32 | MAP2K4 | 1.34389480 |
| 33 | JAK1 | 1.34047031 |
| 34 | CSK | 1.33003524 |
| 35 | PRKG2 | 1.26436279 |
| 36 | MAP3K11 | 1.22287614 |
| 37 | TIE1 | 1.19898812 |
| 38 | ERBB4 | 1.16691727 |
| 39 | CDK7 | 1.16252036 |
| 40 | FLT3 | 1.16209219 |
| 41 | CSF1R | 1.12429454 |
| 42 | MAP3K14 | 1.09732453 |
| 43 | TTN | 1.08032944 |
| 44 | MAP3K13 | 1.08015617 |
| 45 | JAK2 | 1.07813939 |
| 46 | MAPK11 | 1.04530576 |
| 47 | ABL2 | 1.03823854 |
| 48 | ZAP70 | 1.02413141 |
| 49 | NEK9 | 0.99935877 |
| 50 | PIK3CA | 0.97042227 |
| 51 | MAP3K10 | 0.94959921 |
| 52 | GRK5 | 0.94639105 |
| 53 | EIF2AK1 | 0.93001594 |
| 54 | PIK3CG | 0.88714881 |
| 55 | MAP3K7 | 0.87828896 |
| 56 | IRAK4 | 0.85891715 |
| 57 | PRKCH | 0.85698247 |
| 58 | FES | 0.85559980 |
| 59 | STK10 | 0.84387042 |
| 60 | IKBKE | 0.82793459 |
| 61 | KDR | 0.82339061 |
| 62 | HIPK2 | 0.81277978 |
| 63 | FGR | 0.80658899 |
| 64 | CAMKK1 | 0.79943967 |
| 65 | HCK | 0.78809751 |
| 66 | RPS6KL1 | 0.78098627 |
| 67 | RPS6KC1 | 0.78098627 |
| 68 | MAP2K2 | 0.77175678 |
| 69 | TXK | 0.74675320 |
| 70 | MAPK12 | 0.74661506 |
| 71 | PRKAA2 | 0.74278439 |
| 72 | NTRK3 | 0.73855075 |
| 73 | EPHA3 | 0.73366750 |
| 74 | IGF1R | 0.71433089 |
| 75 | MAP3K3 | 0.69695238 |
| 76 | EGFR | 0.67688311 |
| 77 | SCYL2 | 0.66909526 |
| 78 | IRAK3 | 0.66107569 |
| 79 | MAP2K1 | 0.62199595 |
| 80 | MAPK4 | 0.61804747 |
| 81 | ITK | 0.61042835 |
| 82 | LRRK2 | 0.60692175 |
| 83 | PDPK1 | 0.59455509 |
| 84 | FGFR3 | 0.59357603 |
| 85 | ERBB2 | 0.59215737 |
| 86 | JAK3 | 0.58562320 |
| 87 | SYK | 0.57935540 |
| 88 | BTK | 0.57152461 |
| 89 | PTK2 | 0.55814586 |
| 90 | SGK3 | 0.52942076 |
| 91 | LCK | 0.51803416 |
| 92 | MAP3K5 | 0.51617548 |
| 93 | PRKACG | 0.50846546 |
| 94 | CDK6 | 0.49980665 |
| 95 | MAPK3 | 0.49592680 |
| 96 | SIK2 | 0.49384631 |
| 97 | SMG1 | 0.49375978 |
| 98 | GSK3A | 0.47959758 |
| 99 | LYN | 0.47718096 |
| 100 | RET | 0.45654812 |
| 101 | IKBKB | 0.45048138 |
| 102 | EPHB2 | 0.44575554 |
| 103 | MATK | 0.44558669 |
| 104 | PRKCZ | 0.44318359 |
| 105 | PIM1 | 0.44235605 |
| 106 | FGFR1 | 0.42347386 |
| 107 | MARK2 | 0.41839339 |
| 108 | DAPK1 | 0.41079182 |
| 109 | MYLK | 0.41047489 |
| 110 | PDK1 | 0.40125183 |
| 111 | MAP3K6 | 0.38903750 |
| 112 | MAP3K1 | 0.38513813 |
| 113 | RIPK4 | 0.38349894 |
| 114 | FYN | 0.37698922 |
| 115 | SIK3 | 0.37392216 |
| 116 | PRKD2 | 0.37222755 |
| 117 | CAMK4 | 0.36481224 |
| 118 | DYRK1B | 0.36401005 |
| 119 | CDK4 | 0.36350442 |
| 120 | ILK | 0.35284655 |
| 121 | MAPK7 | 0.34836414 |
| 122 | PRKCQ | 0.34310693 |
| 123 | DAPK3 | 0.32708958 |
| 124 | MARK3 | 0.31154424 |
| 125 | NTRK1 | 0.29785917 |
| 126 | PKN1 | 0.29131817 |
| 127 | RPS6KA2 | 0.28350594 |
| 128 | RPS6KA6 | 0.28275092 |
| 129 | CAMKK2 | 0.27388694 |
| 130 | FRK | 0.25421666 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 4.21472420 |
| 2 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.18053467 |
| 3 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 3.93168167 |
| 4 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.71693003 |
| 5 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.21683766 |
| 6 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.07811372 |
| 7 | Arginine biosynthesis_Homo sapiens_hsa00220 | 3.04026749 |
| 8 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.40598585 |
| 9 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.40248198 |
| 10 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.38250234 |
| 11 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.29947800 |
| 12 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.29805885 |
| 13 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.27209785 |
| 14 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.12316087 |
| 15 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.05055977 |
| 16 | Histidine metabolism_Homo sapiens_hsa00340 | 1.91444334 |
| 17 | Peroxisome_Homo sapiens_hsa04146 | 1.84466741 |
| 18 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.81178561 |
| 19 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.79482966 |
| 20 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.73722934 |
| 21 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.66228885 |
| 22 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.66194647 |
| 23 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.65306359 |
| 24 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.61600837 |
| 25 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.59392975 |
| 26 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.57457115 |
| 27 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.55102795 |
| 28 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.46731810 |
| 29 | Bile secretion_Homo sapiens_hsa04976 | 1.40985608 |
| 30 | Asthma_Homo sapiens_hsa05310 | 1.38769377 |
| 31 | Retinol metabolism_Homo sapiens_hsa00830 | 1.38767579 |
| 32 | ABC transporters_Homo sapiens_hsa02010 | 1.31869893 |
| 33 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.31200075 |
| 34 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.30012763 |
| 35 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.27453336 |
| 36 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.25659729 |
| 37 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.25640105 |
| 38 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.21668265 |
| 39 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.17958690 |
| 40 | Other glycan degradation_Homo sapiens_hsa00511 | 1.17540898 |
| 41 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.12354095 |
| 42 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.10874010 |
| 43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.05877824 |
| 44 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.04640285 |
| 45 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.04449725 |
| 46 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.02816308 |
| 47 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.02140568 |
| 48 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.00621447 |
| 49 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.96570208 |
| 50 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.96070334 |
| 51 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.92839353 |
| 52 | Carbon metabolism_Homo sapiens_hsa01200 | 0.90364421 |
| 53 | Lysine degradation_Homo sapiens_hsa00310 | 0.87669898 |
| 54 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.87551405 |
| 55 | Sulfur relay system_Homo sapiens_hsa04122 | 0.87186601 |
| 56 | Prion diseases_Homo sapiens_hsa05020 | 0.84207214 |
| 57 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.82529018 |
| 58 | Pertussis_Homo sapiens_hsa05133 | 0.80316917 |
| 59 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.80144655 |
| 60 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.75846227 |
| 61 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.71147463 |
| 62 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.61104674 |
| 63 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.58496702 |
| 64 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.58411504 |
| 65 | Lysosome_Homo sapiens_hsa04142 | 0.57543083 |
| 66 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.57519465 |
| 67 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.56210744 |
| 68 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.54488676 |
| 69 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.53499699 |
| 70 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.53406135 |
| 71 | Allograft rejection_Homo sapiens_hsa05330 | 0.51843192 |
| 72 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.50644801 |
| 73 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.47036441 |
| 74 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.45257561 |
| 75 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.44404104 |
| 76 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.43915073 |
| 77 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.40382032 |
| 78 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.39712630 |
| 79 | Malaria_Homo sapiens_hsa05144 | 0.35659080 |
| 80 | Leishmaniasis_Homo sapiens_hsa05140 | 0.35490812 |
| 81 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.32645125 |
| 82 | Insulin resistance_Homo sapiens_hsa04931 | 0.32154870 |
| 83 | Metabolic pathways_Homo sapiens_hsa01100 | 0.30378256 |
| 84 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.29514521 |
| 85 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.29410274 |
| 86 | Galactose metabolism_Homo sapiens_hsa00052 | 0.28834742 |
| 87 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.25616515 |
| 88 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.23452812 |
| 89 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.21782669 |
| 90 | Amoebiasis_Homo sapiens_hsa05146 | 0.21539701 |
| 91 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.16489831 |
| 92 | Legionellosis_Homo sapiens_hsa05134 | 0.15343828 |
| 93 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.15057701 |
| 94 | Phagosome_Homo sapiens_hsa04145 | 0.13707029 |
| 95 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.05952343 |
| 96 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.05448673 |
| 97 | Tuberculosis_Homo sapiens_hsa05152 | 0.04975281 |
| 98 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.03436754 |
| 99 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.03191805 |
| 100 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.03158926 |
| 101 | Mineral absorption_Homo sapiens_hsa04978 | 0.03097999 |
| 102 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.02387487 |
| 103 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.02354822 |
| 104 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.02275868 |
| 105 | Platelet activation_Homo sapiens_hsa04611 | 0.02182379 |
| 106 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.01165410 |
| 107 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.1079692 |
| 108 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | -0.0926720 |
| 109 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.0853006 |
| 110 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | -0.0739958 |
| 111 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | -0.0598811 |
| 112 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.0291587 |
| 113 | Herpes simplex infection_Homo sapiens_hsa05168 | -0.0275402 |
| 114 | Toxoplasmosis_Homo sapiens_hsa05145 | -0.0265442 |
| 115 | Hepatitis C_Homo sapiens_hsa05160 | -0.0217333 |
| 116 | AMPK signaling pathway_Homo sapiens_hsa04152 | -0.0184770 |
| 117 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | -0.0136849 |
| 118 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | -0.0088972 |

