CD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.62218987
2negative thymic T cell selection (GO:0045060)8.44253030
3positive regulation of gamma-delta T cell activation (GO:0046645)8.12221579
4positive thymic T cell selection (GO:0045059)7.63014794
5positive regulation of interleukin-2 biosynthetic process (GO:0045086)7.26595652
6positive T cell selection (GO:0043368)7.11344870
7thymic T cell selection (GO:0045061)7.09716401
8regulation of gamma-delta T cell differentiation (GO:0045586)6.97917198
9regulation of isotype switching to IgG isotypes (GO:0048302)6.96663473
10response to interleukin-15 (GO:0070672)6.87327651
11negative regulation of cell killing (GO:0031342)6.83225730
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.83225730
13T cell selection (GO:0045058)6.62634790
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.38429547
15cellular response to interleukin-15 (GO:0071350)6.34335320
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.28246291
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.28246291
18regulation of gamma-delta T cell activation (GO:0046643)6.27257221
19interferon-gamma production (GO:0032609)5.87878578
20regulation of interleukin-2 biosynthetic process (GO:0045076)5.81227603
21regulation of T cell tolerance induction (GO:0002664)5.68028957
22leukocyte aggregation (GO:0070486)5.47157541
23T cell receptor signaling pathway (GO:0050852)5.45303486
24antigen processing and presentation of endogenous antigen (GO:0019883)5.36224544
25T cell costimulation (GO:0031295)5.31780373
26tolerance induction (GO:0002507)5.27097335
27lymphocyte costimulation (GO:0031294)5.24371353
28T cell migration (GO:0072678)5.19858636
29regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.82520894
30positive regulation of interleukin-2 production (GO:0032743)4.73064016
31activated T cell proliferation (GO:0050798)4.72984367
32regulation of alpha-beta T cell proliferation (GO:0046640)4.63573465
33positive regulation of tolerance induction (GO:0002645)4.62816650
34regulation of interleukin-12 biosynthetic process (GO:0045075)4.62000389
35regulation of regulatory T cell differentiation (GO:0045589)4.53869875
36positive regulation of granulocyte differentiation (GO:0030854)4.53518808
37antigen receptor-mediated signaling pathway (GO:0050851)4.42451427
38positive regulation of alpha-beta T cell proliferation (GO:0046641)4.33895399
39regulation of T cell receptor signaling pathway (GO:0050856)4.30117284
40positive regulation of isotype switching (GO:0045830)4.28965867
41positive regulation of humoral immune response (GO:0002922)4.18808130
42regulation of isotype switching (GO:0045191)4.16221065
43positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.14204608
44positive regulation of natural killer cell mediated immunity (GO:0002717)4.14204608
45regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.11740367
46regulation of B cell receptor signaling pathway (GO:0050855)4.11032612
47regulation of tolerance induction (GO:0002643)4.03231702
48negative regulation of T cell mediated immunity (GO:0002710)4.03044465
49regulation of natural killer cell mediated immunity (GO:0002715)4.00887237
50regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.00887237
51positive regulation of B cell mediated immunity (GO:0002714)3.81373597
52positive regulation of immunoglobulin mediated immune response (GO:0002891)3.81373597
53regulation of interleukin-2 production (GO:0032663)3.80045164
54regulation of immunoglobulin mediated immune response (GO:0002889)3.76870045
55positive regulation of DNA recombination (GO:0045911)3.68014812
56negative regulation of leukocyte mediated immunity (GO:0002704)3.65172825
57CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.64942805
58regulation of B cell mediated immunity (GO:0002712)3.63475212
59regulation of response to interferon-gamma (GO:0060330)3.62572136
60regulation of immunoglobulin production (GO:0002637)3.62255208
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.62028209
62T cell differentiation (GO:0030217)3.61318900
63regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.59798916
64regulation of T cell mediated cytotoxicity (GO:0001914)3.55378271
65NIK/NF-kappaB signaling (GO:0038061)3.52775692
66positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.52037781
67JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.51918657
68regulation of defense response to virus by virus (GO:0050690)3.51268334
69positive regulation of immunoglobulin production (GO:0002639)3.49295985
70positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.47142849
71alpha-beta T cell differentiation (GO:0046632)3.46770556
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.46487869
73positive regulation of T cell mediated cytotoxicity (GO:0001916)3.43961271
74alpha-beta T cell activation (GO:0046631)3.43910779
75regulation of leukocyte mediated cytotoxicity (GO:0001910)3.42500829
76mast cell activation (GO:0045576)3.41847778
77negative regulation of lymphocyte mediated immunity (GO:0002707)3.41042582
78positive regulation of B cell differentiation (GO:0045579)3.40276228
79T cell homeostasis (GO:0043029)3.39705275
80negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.38495994
81B cell receptor signaling pathway (GO:0050853)3.37259489
82detection of bacterium (GO:0016045)3.35953352
83T cell activation (GO:0042110)3.32669838
84regulation of type I interferon-mediated signaling pathway (GO:0060338)3.29301750
85regulation of granulocyte differentiation (GO:0030852)3.28468366
86Peyers patch development (GO:0048541)3.27752785
87mucosal-associated lymphoid tissue development (GO:0048537)3.27752785
88positive regulation of interleukin-4 production (GO:0032753)3.26930555
89positive regulation of T cell differentiation in thymus (GO:0033089)3.23962953
90detection of other organism (GO:0098543)3.23321763
91regulation of interleukin-4 production (GO:0032673)3.21196253
92positive regulation of T cell activation (GO:0050870)3.20396756
93leukocyte cell-cell adhesion (GO:0007159)3.20193469
94natural killer cell differentiation (GO:0001779)3.19549162
95positive regulation of cell killing (GO:0031343)3.19305354
96CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.19131196
97T-helper cell differentiation (GO:0042093)3.19131196
98T cell proliferation (GO:0042098)3.19008543
99lymphocyte migration (GO:0072676)3.16497274
100negative regulation of T-helper cell differentiation (GO:0045623)3.16415504
101negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.16415504
102tyrosine phosphorylation of STAT protein (GO:0007260)3.15656843
103positive regulation of lymphocyte mediated immunity (GO:0002708)3.15153265
104cellular response to interleukin-4 (GO:0071353)3.14981790
105regulation of cell killing (GO:0031341)3.14955408
106lymphocyte homeostasis (GO:0002260)3.14604183
107cellular response to type I interferon (GO:0071357)3.13433506
108type I interferon signaling pathway (GO:0060337)3.13433506
109response to type I interferon (GO:0034340)3.12852004
110modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.12594592
111modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.12594592
112positive regulation by organism of defense response of other organism involved in symbiotic interact3.12594592
113modulation by symbiont of host immune response (GO:0052553)3.12594592
114positive regulation by symbiont of host defense response (GO:0052509)3.12594592
115modulation by symbiont of host defense response (GO:0052031)3.12594592
116positive regulation of natural killer cell differentiation (GO:0032825)3.10768155
117natural killer cell activation (GO:0030101)3.10077646
118antigen processing and presentation via MHC class Ib (GO:0002475)3.09507203
119regulation of immunoglobulin secretion (GO:0051023)3.09053852
120cellular extravasation (GO:0045123)3.08061197
121regulation of lymphocyte mediated immunity (GO:0002706)3.07998277
122myeloid dendritic cell differentiation (GO:0043011)3.07578301
123regulation of chronic inflammatory response (GO:0002676)3.06366424
124tumor necrosis factor-mediated signaling pathway (GO:0033209)3.06272132
125negative regulation of phagocytosis (GO:0050765)3.05964695
126negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.05327187
127CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.05202674
128sequestering of actin monomers (GO:0042989)3.04240354
129immune response-activating cell surface receptor signaling pathway (GO:0002429)3.03796062
130negative regulation of erythrocyte differentiation (GO:0045647)3.02323842
131regulation of B cell differentiation (GO:0045577)3.00934869
132positive regulation of alpha-beta T cell activation (GO:0046635)3.00415612
133negative regulation of T cell receptor signaling pathway (GO:0050860)3.00150825
134lymph node development (GO:0048535)2.98494475
135negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.97930325
136regulation of alpha-beta T cell activation (GO:0046634)2.97250028
137myeloid dendritic cell activation (GO:0001773)2.96864025
138positive regulation of T cell differentiation (GO:0045582)2.95397000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.24667040
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.01043458
3MYC_22102868_ChIP-Seq_BL_Human3.90736677
4E2F7_22180533_ChIP-Seq_HELA_Human3.79552662
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.77547541
6STAT4_19710469_ChIP-ChIP_TH1__Mouse3.61587921
7RUNX_20019798_ChIP-Seq_JUKART_Human3.61582654
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.60013501
9* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.40397633
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.38320550
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.30761293
12MYB_26560356_Chip-Seq_TH2_Human3.26806999
13MAF_26560356_Chip-Seq_TH1_Human3.07565836
14UTX_26944678_Chip-Seq_JUKART_Human2.79930412
15MYB_26560356_Chip-Seq_TH1_Human2.78378758
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72862578
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.64228298
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61513520
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.55618875
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.53717155
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50937395
22MAF_26560356_Chip-Seq_TH2_Human2.34482475
23VDR_21846776_ChIP-Seq_THP-1_Human2.32604666
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.17261644
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08081972
26GATA3_27048872_Chip-Seq_THYMUS_Human2.02335065
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00528197
28TCF7_22412390_ChIP-Seq_EML_Mouse1.91543367
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91216497
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84159826
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83866336
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.81694708
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.81338384
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77480664
35KDM2B_26808549_Chip-Seq_DND41_Human1.74348449
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73287514
37SPI1_23547873_ChIP-Seq_NB4_Human1.71512987
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66044749
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64824855
40VDR_24763502_ChIP-Seq_THP-1_Human1.64437775
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59218530
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57547400
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55981541
44CIITA_25753668_ChIP-Seq_RAJI_Human1.55618503
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52129235
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49888475
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49004683
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46882218
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44446999
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.41247685
51SCL_19346495_ChIP-Seq_HPC-7_Human1.37866323
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36317459
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35925475
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34735811
55* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32815942
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31340597
57FOXP3_21729870_ChIP-Seq_TREG_Human1.29196177
58SPI1_23127762_ChIP-Seq_K562_Human1.28938267
59* VDR_23849224_ChIP-Seq_CD4+_Human1.26394319
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25547339
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22737102
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.20600088
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18642119
64GATA3_26560356_Chip-Seq_TH2_Human1.14650686
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.14069012
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11231171
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.11053893
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10812504
69PU_27001747_Chip-Seq_BMDM_Mouse1.07621974
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07402787
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07222914
72VDR_24787735_ChIP-Seq_THP-1_Human1.04128450
73FOXM1_23109430_ChIP-Seq_U2OS_Human0.99691388
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97247396
75ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95247215
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94245756
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94154391
78SMAD_19615063_ChIP-ChIP_OVARY_Human0.94050186
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93529117
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93234304
81BCL6_27268052_Chip-Seq_Bcells_Human0.93058837
82GATA1_19941826_ChIP-Seq_K562_Human0.92596162
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92592140
84MYC_18555785_ChIP-Seq_MESCs_Mouse0.92526091
85XRN2_22483619_ChIP-Seq_HELA_Human0.91845834
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90326557
87* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89894653
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89823548
89CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88137413
90ELK1_19687146_ChIP-ChIP_HELA_Human0.87991727
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86996713
92BCOR_27268052_Chip-Seq_Bcells_Human0.86807962
93* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86807002
94* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86480187
95MYC_19079543_ChIP-ChIP_MESCs_Mouse0.82709332
96KDM5A_27292631_Chip-Seq_BREAST_Human0.80129701
97HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80003296
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79787112
99* SA1_27219007_Chip-Seq_ERYTHROID_Human0.79002671
100GABP_17652178_ChIP-ChIP_JURKAT_Human0.78667835
101* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78038704
102SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.77846536
103EST1_17652178_ChIP-ChIP_JURKAT_Human0.77817552
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.77223361
105GATA3_26560356_Chip-Seq_TH1_Human0.76667722
106NCOR1_26117541_ChIP-Seq_K562_Human0.76403461
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75470142
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.74591685
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73728538
110* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73633394
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73252081
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73129177
113RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72523055
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72042210
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71264366
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.69997945
117LXR_22292898_ChIP-Seq_THP-1_Human0.69385457
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.68178327
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67787943
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66879392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.29018779
2MP0005671_abnormal_response_to4.42179144
3MP0000685_abnormal_immune_system3.81765737
4MP0001800_abnormal_humoral_immune3.18244621
5MP0002166_altered_tumor_susceptibility3.17536661
6MP0009333_abnormal_splenocyte_physiolog3.10134963
7MP0001790_abnormal_immune_system3.06798080
8MP0005387_immune_system_phenotype3.06798080
9MP0001835_abnormal_antigen_presentation3.04983449
10MP0005000_abnormal_immune_tolerance2.93558686
11MP0002398_abnormal_bone_marrow2.85899921
12MP0003436_decreased_susceptibility_to2.84125685
13MP0000703_abnormal_thymus_morphology2.80999281
14MP0002420_abnormal_adaptive_immunity2.78588929
15MP0002723_abnormal_immune_serum2.77296332
16MP0001819_abnormal_immune_cell2.73510033
17MP0002405_respiratory_system_inflammati2.69677626
18MP0003866_abnormal_defecation2.67307495
19MP0001873_stomach_inflammation2.60990625
20MP0002006_tumorigenesis2.60534486
21MP0002396_abnormal_hematopoietic_system2.59351210
22MP0003300_gastrointestinal_ulcer2.59339658
23MP0009785_altered_susceptibility_to2.56120549
24MP0002933_joint_inflammation2.53396290
25MP0002452_abnormal_antigen_presenting2.48212618
26MP0000716_abnormal_immune_system2.43864931
27MP0006082_CNS_inflammation2.40425584
28MP0005025_abnormal_response_to2.35973595
29MP0002722_abnormal_immune_system2.34634661
30MP0010155_abnormal_intestine_physiology2.33142735
31MP0003724_increased_susceptibility_to2.25656038
32MP0000689_abnormal_spleen_morphology2.25571451
33MP0004947_skin_inflammation2.10637920
34MP0002429_abnormal_blood_cell1.99136791
35MP0002148_abnormal_hypersensitivity_rea1.90283422
36MP0003303_peritoneal_inflammation1.87000348
37MP0004510_myositis1.73950612
38MP0001845_abnormal_inflammatory_respons1.64794367
39MP0001853_heart_inflammation1.63360949
40MP0002419_abnormal_innate_immunity1.61613026
41MP0004381_abnormal_hair_follicle1.61201097
42MP0004808_abnormal_hematopoietic_stem1.53002542
43MP0005464_abnormal_platelet_physiology1.43155081
44MP0002277_abnormal_respiratory_mucosa1.39986100
45MP0005310_abnormal_salivary_gland1.36559261
46MP0000858_altered_metastatic_potential1.31531536
47MP0000465_gastrointestinal_hemorrhage1.21157857
48MP0010352_gastrointestinal_tract_polyps1.17247125
49MP0001533_abnormal_skeleton_physiology1.16807680
50MP0000490_abnormal_crypts_of1.15414862
51MP0008057_abnormal_DNA_replication1.13665296
52MP0001851_eye_inflammation1.11354216
53MP0003448_altered_tumor_morphology1.10311107
54MP0005451_abnormal_body_composition1.05321893
55MP0008469_abnormal_protein_level1.04519539
56MP0002019_abnormal_tumor_incidence1.00671957
57MP0003172_abnormal_lysosome_physiology0.98283038
58MP0008961_abnormal_basal_metabolism0.96629630
59MP0008260_abnormal_autophagy0.96052054
60MP0005075_abnormal_melanosome_morpholog0.94592766
61MP0004130_abnormal_muscle_cell0.91435922
62MP0001545_abnormal_hematopoietic_system0.90207298
63MP0005397_hematopoietic_system_phenotyp0.90207298
64MP0002254_reproductive_system_inflammat0.89161006
65MP0005023_abnormal_wound_healing0.84153195
66MP0002009_preneoplasia0.84110030
67MP0003191_abnormal_cellular_cholesterol0.84091478
68MP0005076_abnormal_cell_differentiation0.84076895
69MP0003077_abnormal_cell_cycle0.83739510
70MP0002138_abnormal_hepatobiliary_system0.83214455
71MP0002822_catalepsy0.81713595
72MP0003828_pulmonary_edema0.80632679
73MP0001348_abnormal_lacrimal_gland0.80544281
74MP0002998_abnormal_bone_remodeling0.80373930
75MP0003693_abnormal_embryo_hatching0.77883370
76MP0002132_abnormal_respiratory_system0.75150552
77MP0001986_abnormal_taste_sensitivity0.73962990
78MP0009765_abnormal_xenobiotic_induced0.68791152
79MP0005166_decreased_susceptibility_to0.68046131
80MP0004883_abnormal_blood_vessel0.67272818
81MP0004957_abnormal_blastocyst_morpholog0.64482550
82MP0009763_increased_sensitivity_to0.64057260
83MP0010094_abnormal_chromosome_stability0.62530957
84MP0003045_fibrosis0.61711388
85MP0000477_abnormal_intestine_morphology0.61399182
86MP0005381_digestive/alimentary_phenotyp0.59455495
87MP0000609_abnormal_liver_physiology0.59024755
88MP0003795_abnormal_bone_structure0.58128795
89MP0001243_abnormal_dermal_layer0.58039937
90MP0001663_abnormal_digestive_system0.56163457
91MP0000604_amyloidosis0.55837346
92MP0001216_abnormal_epidermal_layer0.52257151
93MP0009278_abnormal_bone_marrow0.51657374
94MP0000249_abnormal_blood_vessel0.51373624
95MP0000313_abnormal_cell_death0.51077578
96MP0008995_early_reproductive_senescence0.50966918
97MP0003453_abnormal_keratinocyte_physiol0.50713083
98MP0001881_abnormal_mammary_gland0.49587010
99MP0002928_abnormal_bile_duct0.49089743
100MP0009764_decreased_sensitivity_to0.48434021
101MP0001191_abnormal_skin_condition0.47174985
102MP0008007_abnormal_cellular_replicative0.46889009
103MP0000350_abnormal_cell_proliferation0.46539553
104MP0003221_abnormal_cardiomyocyte_apopto0.46035932
105MP0009115_abnormal_fat_cell0.45732893
106MP0001919_abnormal_reproductive_system0.45140019
107MP0001501_abnormal_sleep_pattern0.45064280
108MP0003111_abnormal_nucleus_morphology0.42096790
109MP0008874_decreased_physiological_sensi0.41812465
110MP0004185_abnormal_adipocyte_glucose0.41707982
111MP0003091_abnormal_cell_migration0.41668464
112MP0002136_abnormal_kidney_physiology0.41412417
113MP0009840_abnormal_foam_cell0.41267591
114MP0008058_abnormal_DNA_repair0.40464215
115MP0005535_abnormal_body_temperature0.39915994
116MP0002163_abnormal_gland_morphology0.39762852
117MP0001730_embryonic_growth_arrest0.39174227
118MP0008569_lethality_at_weaning0.38450554
119MP0000367_abnormal_coat/_hair0.38335477
120MP0005390_skeleton_phenotype0.38028868
121MP0003252_abnormal_bile_duct0.37687528
122MP0002693_abnormal_pancreas_physiology0.36654008
123MP0003183_abnormal_peptide_metabolism0.36292013
124MP0008873_increased_physiological_sensi0.36214838

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.20571838
2Abnormality of T cell number (HP:0011839)7.91462902
3Severe combined immunodeficiency (HP:0004430)6.27412210
4Combined immunodeficiency (HP:0005387)5.81074484
5Stomatitis (HP:0010280)5.77639590
6Abnormality of T cells (HP:0002843)5.76321040
7Elevated erythrocyte sedimentation rate (HP:0003565)5.58516372
8Recurrent fungal infections (HP:0002841)5.19349540
9Panhypogammaglobulinemia (HP:0003139)5.18073749
10Recurrent bronchitis (HP:0002837)5.05745443
11Recurrent cutaneous fungal infections (HP:0011370)4.83395425
12Chronic mucocutaneous candidiasis (HP:0002728)4.83395425
13Recurrent viral infections (HP:0004429)4.58774394
14Chronic diarrhea (HP:0002028)4.57422376
15Nasal polyposis (HP:0100582)4.54837258
16Eczematoid dermatitis (HP:0000976)4.49810896
17Chronic otitis media (HP:0000389)4.49579563
18IgG deficiency (HP:0004315)4.49059853
19IgM deficiency (HP:0002850)4.44880147
20Autoimmune hemolytic anemia (HP:0001890)4.11405754
21Recurrent bacterial skin infections (HP:0005406)4.11112141
22Abnormality of eosinophils (HP:0001879)3.97301017
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.92016694
24Abnormality of the nasal mucosa (HP:0000433)3.74196683
25Eosinophilia (HP:0001880)3.72311369
26Increased IgM level (HP:0003496)3.70854365
27Joint swelling (HP:0001386)3.67413027
28Abnormality of B cell number (HP:0010975)3.66154065
29B lymphocytopenia (HP:0010976)3.66154065
30Abnormality of T cell physiology (HP:0011840)3.64472573
31Pustule (HP:0200039)3.63808877
32Abnormality of macrophages (HP:0004311)3.61007526
33Abnormality of the fingertips (HP:0001211)3.58104979
34Leukocytosis (HP:0001974)3.56884397
35Lymphopenia (HP:0001888)3.51670004
36Abnormality of cells of the lymphoid lineage (HP:0012140)3.43672395
37Myositis (HP:0100614)3.42306698
38IgA deficiency (HP:0002720)3.26432230
39Granulocytopenia (HP:0001913)3.25772434
40Gastrointestinal infarctions (HP:0005244)3.17579167
41Thyroiditis (HP:0100646)3.17419648
42Hemoptysis (HP:0002105)3.15911807
43Prolonged bleeding time (HP:0003010)2.99842990
44Basal cell carcinoma (HP:0002671)2.99390210
45Hypochromic anemia (HP:0001931)2.96747498
46Cheilitis (HP:0100825)2.88244618
47Papilledema (HP:0001085)2.85666117
48Bronchitis (HP:0012387)2.83479504
49Pulmonary infiltrates (HP:0002113)2.80144037
50Recurrent gram-negative bacterial infections (HP:0005420)2.75710494
51Lymphoma (HP:0002665)2.74403119
52Thrombocytosis (HP:0001894)2.73195484
53Vasculitis (HP:0002633)2.67334234
54Recurrent sinusitis (HP:0011108)2.66812359
55Hypoplasia of the thymus (HP:0000778)2.66295790
56Mediastinal lymphadenopathy (HP:0100721)2.65541359
57Autoimmune thrombocytopenia (HP:0001973)2.63883466
58Inflammation of the large intestine (HP:0002037)2.57461318
59Hypergammaglobulinemia (HP:0010702)2.56129383
60Increased IgE level (HP:0003212)2.53553853
61Gastrointestinal inflammation (HP:0004386)2.52651478
62Gingivitis (HP:0000230)2.51767905
63Retrobulbar optic neuritis (HP:0100654)2.51750671
64Optic neuritis (HP:0100653)2.51750671
65Slow saccadic eye movements (HP:0000514)2.48363796
66Meningitis (HP:0001287)2.47342778
67Colitis (HP:0002583)2.46062568
68Recurrent skin infections (HP:0001581)2.44789884
69Stomach cancer (HP:0012126)2.42074019
70Increased density of long bones (HP:0006392)2.39822128
71Hypochromic microcytic anemia (HP:0004840)2.38849633
72Spontaneous hematomas (HP:0007420)2.32057364
73Chest pain (HP:0100749)2.29168674
74Cellulitis (HP:0100658)2.28174676
75Chronic obstructive pulmonary disease (HP:0006510)2.23286468
76Obstructive lung disease (HP:0006536)2.23286468
77Chronic sinusitis (HP:0011109)2.23165117
78Urticaria (HP:0001025)2.22917384
79Arterial thrombosis (HP:0004420)2.19748702
80Ureteral stenosis (HP:0000071)2.17471300
81Encephalitis (HP:0002383)2.16762361
82Orchitis (HP:0100796)2.15605126
83Papilloma (HP:0012740)2.15141986
84Verrucae (HP:0200043)2.15141986
85Microcytic anemia (HP:0001935)2.14756150
86Hemiplegia (HP:0002301)2.14018413
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13081992
88Acute hepatic failure (HP:0006554)2.08886269
89Recurrent otitis media (HP:0000403)2.08230822
90Anorexia (HP:0002039)2.08085709
91Amaurosis fugax (HP:0100576)2.05867040
92Persistence of primary teeth (HP:0006335)2.05270682
93Sepsis (HP:0100806)2.01513925
94Abnormality of the prostate (HP:0008775)1.99898852
95Hepatitis (HP:0012115)1.97322555
96Bronchiectasis (HP:0002110)1.96550685
97Abnormal platelet volume (HP:0011876)1.96212695
98Ureteral obstruction (HP:0006000)1.94859204
99Alveolar cell carcinoma (HP:0006519)1.94237500
100Segmental peripheral demyelination/remyelination (HP:0003481)1.94049581
101Episodic fever (HP:0001954)1.93791801
102Abnormality of the pleura (HP:0002103)1.91751543
103Seborrheic dermatitis (HP:0001051)1.91538553
104Epistaxis (HP:0000421)1.91278715
105Recurrent abscess formation (HP:0002722)1.90159694
106Pulmonary embolism (HP:0002204)1.89591092
107Poikiloderma (HP:0001029)1.88895102
108Emphysema (HP:0002097)1.86746991
109Abnormality of the endocardium (HP:0004306)1.86626018
110Keratoconjunctivitis sicca (HP:0001097)1.85708407
111Skin ulcer (HP:0200042)1.79167391
112Agammaglobulinemia (HP:0004432)1.78200389
113Aplasia/Hypoplasia of the thymus (HP:0010515)1.75463569
114Entropion (HP:0000621)1.74971829
115Trigonocephaly (HP:0000243)1.74633145
116Periodontitis (HP:0000704)1.70271108
117Arthralgia (HP:0002829)1.70087056
118Gangrene (HP:0100758)1.69716225
119Keratoconjunctivitis (HP:0001096)1.65294434
120Reduced subcutaneous adipose tissue (HP:0003758)1.63980325
121Gastrointestinal stroma tumor (HP:0100723)1.60016842
122Amyotrophic lateral sclerosis (HP:0007354)1.58541834
123Dislocated radial head (HP:0003083)1.58385771
124Gingival bleeding (HP:0000225)1.57873751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.18315342
2MAP4K15.89644517
3JAK33.88106446
4ZAP703.51600346
5FGFR43.45684604
6ITK3.29969720
7PRPF4B3.25093564
8IKBKE2.77295525
9TYK22.53857310
10STK102.42337951
11NLK2.39456669
12RIPK42.36847651
13MAP3K142.22805213
14LCK2.08613919
15FGFR32.05707533
16TAOK31.99819162
17JAK11.94036298
18EEF2K1.90856417
19GRK61.83409067
20CAMKK21.79235373
21MAP3K101.69337368
22NME21.69297821
23CAMKK11.67104264
24TEC1.64497900
25KDR1.62048500
26CSK1.60675118
27TBK11.59896862
28MST41.35511993
29PRKCH1.33574536
30SYK1.32466305
31ERN11.28463151
32BTK1.23499039
33TESK21.23191252
34PRKCQ1.17812814
35TRIB31.13942340
36MAP3K131.10492726
37IKBKB1.09870613
38SMG11.08170520
39CDK121.05845657
40CHUK1.02299118
41* HCK1.02241841
42PKN21.02082480
43JAK21.00590025
44MAP3K71.00058813
45KIT0.99763133
46TLK10.97327129
47EPHA30.96347403
48TAOK10.96001886
49BLK0.94683711
50TSSK60.92253293
51MARK30.91988792
52LRRK20.89245453
53MAPK120.88490478
54RPS6KA40.87900775
55CLK10.85104512
56TYRO30.85092083
57EPHB10.83476729
58MAP3K10.83298360
59SIK20.82120735
60LYN0.70308317
61PIM10.69619867
62ALK0.69562759
63FGFR10.67964032
64FES0.67022302
65RET0.64285477
66PASK0.64111633
67MARK20.60851954
68SIK30.60183333
69TAOK20.58251531
70PDGFRB0.57993865
71TNK20.57776319
72MAP2K30.57555046
73CDK40.57368783
74BRD40.51725545
75TTN0.50913769
76INSR0.48338471
77MAP3K110.47874752
78PDK10.47452217
79IRAK40.47108503
80TGFBR10.44480925
81FYN0.42433884
82CAMK40.41701850
83TGFBR20.40817402
84FGR0.40578900
85IRAK10.39857528
86YES10.39393232
87MELK0.38669071
88MAP2K20.38402121
89STK110.37229340
90CDC42BPA0.37166633
91PIK3CG0.36844701
92BMPR20.36757246
93KSR20.35992801
94CSF1R0.35962745
95MAP3K80.34000788
96CDK190.32988768
97HIPK20.32338452
98RPS6KA50.32152779
99PRKD20.31900192
100SIK10.31518793
101MAPK110.30909449
102STK380.30655306
103NTRK20.30029868
104CDC70.29919065
105UHMK10.29783499
106NEK60.29275859
107EGFR0.29224863
108MAP3K40.29010407
109ROCK20.28596439
110PTK60.28196449
111DMPK0.27088078
112RPS6KL10.26644673
113RPS6KC10.26644673
114PDPK10.26138318
115MAP2K60.25294986
116MAPK30.24904538
117MAP3K120.24190628
118FGFR20.23658732
119STK40.22049547
120MAPK70.21688193
121MAPKAPK20.21427663
122CDK90.20994434
123RAF10.20102479
124CHEK10.19524207
125MAP3K30.19230064
126CDK60.17941438
127* IGF1R0.17224475
128MAPK40.16446338
129PIM20.16316194
130SRC0.15639983

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.98184318
2T cell receptor signaling pathway_Homo sapiens_hsa046604.37207602
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.56871088
4Measles_Homo sapiens_hsa051623.04366848
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.83729517
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.75383714
7Allograft rejection_Homo sapiens_hsa053302.72032045
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.53174592
9Graft-versus-host disease_Homo sapiens_hsa053322.42836090
10Antigen processing and presentation_Homo sapiens_hsa046122.29360674
11Autoimmune thyroid disease_Homo sapiens_hsa053202.12891480
12Hematopoietic cell lineage_Homo sapiens_hsa046402.12174664
13Viral myocarditis_Homo sapiens_hsa054162.11275167
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.92902367
15Leishmaniasis_Homo sapiens_hsa051401.88029789
16Osteoclast differentiation_Homo sapiens_hsa043801.79773058
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66529323
18Type I diabetes mellitus_Homo sapiens_hsa049401.59374042
19Herpes simplex infection_Homo sapiens_hsa051681.59117453
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57656926
21B cell receptor signaling pathway_Homo sapiens_hsa046621.53815066
22Acute myeloid leukemia_Homo sapiens_hsa052211.44768877
23Hepatitis B_Homo sapiens_hsa051611.33825157
24Toxoplasmosis_Homo sapiens_hsa051451.33630324
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30354823
26HTLV-I infection_Homo sapiens_hsa051661.29650377
27Chemokine signaling pathway_Homo sapiens_hsa040621.26516222
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20872316
29Shigellosis_Homo sapiens_hsa051311.19313579
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.19056317
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18776669
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17880511
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15927873
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15215156
35Influenza A_Homo sapiens_hsa051641.11509184
36Asthma_Homo sapiens_hsa053101.10186459
37* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08749622
38Pancreatic cancer_Homo sapiens_hsa052121.06279534
39TNF signaling pathway_Homo sapiens_hsa046681.06045410
40Chronic myeloid leukemia_Homo sapiens_hsa052201.00825400
41Epstein-Barr virus infection_Homo sapiens_hsa051691.00302154
42Prolactin signaling pathway_Homo sapiens_hsa049170.98019879
43Legionellosis_Homo sapiens_hsa051340.96474516
44Spliceosome_Homo sapiens_hsa030400.96040839
45Colorectal cancer_Homo sapiens_hsa052100.94557599
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94534976
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94314753
48Viral carcinogenesis_Homo sapiens_hsa052030.93302825
49Apoptosis_Homo sapiens_hsa042100.85960765
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81024673
51Ribosome_Homo sapiens_hsa030100.80792858
52Hepatitis C_Homo sapiens_hsa051600.80408378
53VEGF signaling pathway_Homo sapiens_hsa043700.79393450
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75993550
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68622819
56Platelet activation_Homo sapiens_hsa046110.67374733
57African trypanosomiasis_Homo sapiens_hsa051430.67214537
58Tuberculosis_Homo sapiens_hsa051520.64137233
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.62952079
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62719077
61RNA degradation_Homo sapiens_hsa030180.62518807
62Staphylococcus aureus infection_Homo sapiens_hsa051500.62197357
63ErbB signaling pathway_Homo sapiens_hsa040120.60341400
64Salmonella infection_Homo sapiens_hsa051320.60198089
65Type II diabetes mellitus_Homo sapiens_hsa049300.60150065
66Malaria_Homo sapiens_hsa051440.60100163
67RNA transport_Homo sapiens_hsa030130.58461054
68DNA replication_Homo sapiens_hsa030300.57492344
69mRNA surveillance pathway_Homo sapiens_hsa030150.56461617
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56100318
71Dorso-ventral axis formation_Homo sapiens_hsa043200.56025287
72Thyroid cancer_Homo sapiens_hsa052160.55548777
73p53 signaling pathway_Homo sapiens_hsa041150.55447435
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54176897
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52051279
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.51682489
77Small cell lung cancer_Homo sapiens_hsa052220.50745659
78Non-homologous end-joining_Homo sapiens_hsa034500.50518574
79Ras signaling pathway_Homo sapiens_hsa040140.49408105
80Notch signaling pathway_Homo sapiens_hsa043300.48045732
81GnRH signaling pathway_Homo sapiens_hsa049120.45900626
82One carbon pool by folate_Homo sapiens_hsa006700.45712220
83Regulation of autophagy_Homo sapiens_hsa041400.45632293
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44815755
85Pertussis_Homo sapiens_hsa051330.44099590
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43526044
87Mismatch repair_Homo sapiens_hsa034300.42599502
88Non-small cell lung cancer_Homo sapiens_hsa052230.42486269
89MAPK signaling pathway_Homo sapiens_hsa040100.41355760
90Other glycan degradation_Homo sapiens_hsa005110.41052274
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40705429
92Endocytosis_Homo sapiens_hsa041440.40268377
93Rheumatoid arthritis_Homo sapiens_hsa053230.40133997
94Base excision repair_Homo sapiens_hsa034100.39974527
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.38568098
96Long-term potentiation_Homo sapiens_hsa047200.37701010
97Glioma_Homo sapiens_hsa052140.36733301
98Renal cell carcinoma_Homo sapiens_hsa052110.36640095
99HIF-1 signaling pathway_Homo sapiens_hsa040660.36046818
100Prostate cancer_Homo sapiens_hsa052150.35687970
101Nucleotide excision repair_Homo sapiens_hsa034200.35427788
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.35237638
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35217364
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35095604
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34945084
106mTOR signaling pathway_Homo sapiens_hsa041500.34276966
107Caffeine metabolism_Homo sapiens_hsa002320.33101214
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32691067
109Endometrial cancer_Homo sapiens_hsa052130.31908137
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31872664
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30472376
112Insulin resistance_Homo sapiens_hsa049310.30266020
113Rap1 signaling pathway_Homo sapiens_hsa040150.30153597
114Insulin signaling pathway_Homo sapiens_hsa049100.28219856
115Systemic lupus erythematosus_Homo sapiens_hsa053220.27872997
116FoxO signaling pathway_Homo sapiens_hsa040680.27181654
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.26284428
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.25648408
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25206191
120Adherens junction_Homo sapiens_hsa045200.25024515
121Choline metabolism in cancer_Homo sapiens_hsa052310.23626376
122Inositol phosphate metabolism_Homo sapiens_hsa005620.23546084
123Pathways in cancer_Homo sapiens_hsa052000.23220495

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