CD69

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.25772305
2positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.09007026
3regulation of isotype switching to IgG isotypes (GO:0048302)5.03569048
4regulation of interleukin-12 biosynthetic process (GO:0045075)4.98916685
5interferon-gamma production (GO:0032609)4.81590608
6regulation of gamma-delta T cell differentiation (GO:0045586)4.75900198
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.56134097
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.56134097
9regulation of gamma-delta T cell activation (GO:0046643)4.54140939
10negative T cell selection (GO:0043383)4.54116290
11positive regulation of T cell differentiation in thymus (GO:0033089)4.53941952
12negative regulation of cell killing (GO:0031342)4.51207231
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.51207231
14negative thymic T cell selection (GO:0045060)4.50619368
15cellular response to type I interferon (GO:0071357)4.49904855
16type I interferon signaling pathway (GO:0060337)4.49904855
17T cell migration (GO:0072678)4.49489246
18positive regulation of isotype switching (GO:0045830)4.49207565
19response to type I interferon (GO:0034340)4.47816993
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.44690078
21DNA deamination (GO:0045006)4.27554054
22negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.25613366
23antigen processing and presentation of endogenous antigen (GO:0019883)4.23626829
24positive regulation of immunoglobulin mediated immune response (GO:0002891)4.23493569
25positive regulation of B cell mediated immunity (GO:0002714)4.23493569
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.19286270
27defense response to protozoan (GO:0042832)4.09673934
28positive regulation of alpha-beta T cell proliferation (GO:0046641)4.07647732
29regulation of alpha-beta T cell proliferation (GO:0046640)4.07025313
30regulation of B cell receptor signaling pathway (GO:0050855)3.99762231
31regulation of T cell mediated cytotoxicity (GO:0001914)3.98830912
32leukocyte aggregation (GO:0070486)3.98559501
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.94229433
34positive regulation of DNA recombination (GO:0045911)3.92243124
35positive thymic T cell selection (GO:0045059)3.91460737
36RNA destabilization (GO:0050779)3.86238028
37myeloid dendritic cell activation (GO:0001773)3.82526052
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.78821169
39myeloid dendritic cell differentiation (GO:0043011)3.76996642
40positive regulation of T cell mediated cytotoxicity (GO:0001916)3.75844475
41positive regulation of natural killer cell differentiation (GO:0032825)3.71684618
42positive regulation of interleukin-2 production (GO:0032743)3.71148344
43response to protozoan (GO:0001562)3.69416216
44dendritic cell chemotaxis (GO:0002407)3.68508495
45regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.67167542
46positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.67167542
47positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.66106056
48interferon-gamma-mediated signaling pathway (GO:0060333)3.65642286
49T cell receptor signaling pathway (GO:0050852)3.65298015
50mitotic cell cycle arrest (GO:0071850)3.64969328
51cellular response to interferon-beta (GO:0035458)3.63685559
52regulation of interferon-alpha production (GO:0032647)3.63663576
53regulation of germinal center formation (GO:0002634)3.63256255
54NIK/NF-kappaB signaling (GO:0038061)3.62722070
55positive regulation of interferon-alpha production (GO:0032727)3.62240625
56positive regulation of mRNA catabolic process (GO:0061014)3.60387927
57positive regulation of T cell cytokine production (GO:0002726)3.59729826
58regulation of leukocyte mediated cytotoxicity (GO:0001910)3.58205271
59CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.58047114
60mast cell activation involved in immune response (GO:0002279)3.56918066
61mast cell degranulation (GO:0043303)3.56918066
62thymic T cell selection (GO:0045061)3.54732887
63positive regulation of defense response to virus by host (GO:0002230)3.54598020
64mast cell activation (GO:0045576)3.54389902
65T cell selection (GO:0045058)3.52703822
66cellular response to interleukin-15 (GO:0071350)3.51474015
67regulation of interleukin-2 biosynthetic process (GO:0045076)3.51152954
68response to interleukin-15 (GO:0070672)3.51099001
69antigen receptor-mediated signaling pathway (GO:0050851)3.50357986
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.48731280
71regulation of chronic inflammatory response (GO:0002676)3.48429440
72regulation of RIG-I signaling pathway (GO:0039535)3.44895295
73regulation of immunoglobulin mediated immune response (GO:0002889)3.43331341
74regulation of T-helper 1 cell differentiation (GO:0045625)3.42853895
75regulation of B cell mediated immunity (GO:0002712)3.42648990
76regulation of cell killing (GO:0031341)3.42424323
77positive T cell selection (GO:0043368)3.40210611
78regulation of isotype switching (GO:0045191)3.40065095
79cellular response to exogenous dsRNA (GO:0071360)3.38406379
80immunoglobulin mediated immune response (GO:0016064)3.38265770
81activated T cell proliferation (GO:0050798)3.36298905
82endoderm formation (GO:0001706)3.35936611
83regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.35037421
84positive regulation of T-helper 1 type immune response (GO:0002827)3.35001738
85T-helper cell differentiation (GO:0042093)3.34555747
86CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.34555747
87positive regulation of humoral immune response (GO:0002922)3.34532840
88cytidine metabolic process (GO:0046087)3.34140093
89cytidine catabolic process (GO:0006216)3.34140093
90cytidine deamination (GO:0009972)3.34140093
91regulation of regulatory T cell differentiation (GO:0045589)3.31192441
92positive regulation of T cell mediated immunity (GO:0002711)3.30881552
93positive regulation of cell killing (GO:0031343)3.25498935
94positive regulation of interleukin-17 production (GO:0032740)3.25108276
95nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.23469916
96positive regulation of granulocyte differentiation (GO:0030854)3.23123953
97regulation of immunoglobulin secretion (GO:0051023)3.21798454
98sleep (GO:0030431)3.21339043
99regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.21118416
100positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.21118416
101natural killer cell activation (GO:0030101)3.20409693
102regulation of interleukin-2 production (GO:0032663)3.19237002
103regulation of response to interferon-gamma (GO:0060330)3.18924346
104negative regulation of viral genome replication (GO:0045071)3.18074836
105regulation of T-helper 1 type immune response (GO:0002825)3.17534324
106dendritic cell migration (GO:0036336)3.16555829
107modulation by symbiont of host immune response (GO:0052553)3.15399772
108positive regulation by symbiont of host defense response (GO:0052509)3.15399772
109modulation by symbiont of host defense response (GO:0052031)3.15399772
110modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.15399772
111modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.15399772
112positive regulation by organism of defense response of other organism involved in symbiotic interact3.15399772
113negative regulation of bone resorption (GO:0045779)3.14226851
114regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.14196732
115positive regulation of immune response to tumor cell (GO:0002839)3.14108336
116regulation of immune response to tumor cell (GO:0002837)3.14108336
117regulation of response to tumor cell (GO:0002834)3.14108336
118positive regulation of response to tumor cell (GO:0002836)3.14108336
119positive regulation of immunoglobulin production (GO:0002639)3.13330631
120alpha-beta T cell activation (GO:0046631)3.12965904
121response to interferon-alpha (GO:0035455)3.12873174
122response to muramyl dipeptide (GO:0032495)3.12476835
123regulation of T cell mediated immunity (GO:0002709)3.11834574
124neutrophil activation involved in immune response (GO:0002283)3.11100048
125negative regulation of T cell mediated immunity (GO:0002710)3.10760538
126tolerance induction (GO:0002507)3.10105477
127positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.09194365
128positive regulation of natural killer cell mediated immunity (GO:0002717)3.09194365
129regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08928286
130regulation of mitotic spindle checkpoint (GO:1903504)3.08928286
131negative regulation of interleukin-1 beta production (GO:0032691)3.08855174
132regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.08699722
133regulation of natural killer cell mediated immunity (GO:0002715)3.08699722
134response to peptidoglycan (GO:0032494)3.07435206
135regulation of T cell receptor signaling pathway (GO:0050856)3.07233344
136positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.06593974
137alpha-beta T cell differentiation involved in immune response (GO:0002293)3.05745354
138alpha-beta T cell activation involved in immune response (GO:0002287)3.05745354
139T cell differentiation involved in immune response (GO:0002292)3.05745354
140positive regulation of interleukin-12 production (GO:0032735)3.04569808
141positive regulation of lymphocyte mediated immunity (GO:0002708)3.04364501
142regulation of type I interferon-mediated signaling pathway (GO:0060338)3.04252204
143negative regulation of T cell apoptotic process (GO:0070233)3.04193101
144pyrimidine ribonucleoside catabolic process (GO:0046133)3.03173627
145regulation of interleukin-17 production (GO:0032660)3.02990077
146T cell differentiation (GO:0030217)3.02816785
147positive regulation of alpha-beta T cell activation (GO:0046635)3.01121702
148cellular response to interferon-alpha (GO:0035457)3.00159596
149regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.00013031
150positive regulation of cytokine biosynthetic process (GO:0042108)2.98097132
151regulation of B cell differentiation (GO:0045577)2.97423689
152regulation of mRNA catabolic process (GO:0061013)2.95742444
153regulation of T-helper cell differentiation (GO:0045622)2.94928552
154alpha-beta T cell differentiation (GO:0046632)2.93712944
155regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.92073090
156regulation of defense response to virus by host (GO:0050691)2.91448240
157regulation of fibroblast apoptotic process (GO:2000269)2.90735095
158positive regulation of calcium-mediated signaling (GO:0050850)2.90240255
159peptidyl-threonine dephosphorylation (GO:0035970)2.87402481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.88772286
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.43139990
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.22515448
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.22050343
5IRF8_21731497_ChIP-ChIP_J774_Mouse5.02626803
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.75123492
7BP1_19119308_ChIP-ChIP_Hs578T_Human4.25921097
8* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.88705700
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.62736490
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30946989
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.29324064
12IRF8_27001747_Chip-Seq_BMDM_Mouse3.22329045
13E2F7_22180533_ChIP-Seq_HELA_Human3.07630352
14* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.06753654
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96292076
16RUNX_20019798_ChIP-Seq_JUKART_Human2.86943720
17* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.83370916
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80281057
19* MYB_26560356_Chip-Seq_TH2_Human2.76718228
20* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.52643549
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.51840626
22* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51324136
23* MYB_26560356_Chip-Seq_TH1_Human2.33176240
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29123926
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.22964316
26MAF_26560356_Chip-Seq_TH1_Human2.21803039
27SCL_19346495_ChIP-Seq_HPC-7_Human2.20835696
28SPI1_23547873_ChIP-Seq_NB4_Human2.11047894
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09259370
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00539287
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95265906
32MYC_22102868_ChIP-Seq_BL_Human1.94956806
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.87760282
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83875498
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74393664
36* UTX_26944678_Chip-Seq_JUKART_Human1.68647646
37ZNF274_21170338_ChIP-Seq_K562_Hela1.66192735
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65687337
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65088511
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60616607
41* GATA3_27048872_Chip-Seq_THYMUS_Human1.60087625
42VDR_24763502_ChIP-Seq_THP-1_Human1.60045194
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59010091
44PU_27001747_Chip-Seq_BMDM_Mouse1.56519845
45VDR_22108803_ChIP-Seq_LS180_Human1.55971140
46VDR_21846776_ChIP-Seq_THP-1_Human1.54822777
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46781187
48GATA1_22025678_ChIP-Seq_K562_Human1.46263150
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45330654
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44376284
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36987956
52* GATA3_26560356_Chip-Seq_TH2_Human1.34918146
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34712406
54MAF_26560356_Chip-Seq_TH2_Human1.32905162
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32205337
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31900293
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29785470
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28483020
59* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28368315
60* TCF7_22412390_ChIP-Seq_EML_Mouse1.27122081
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23404532
62IRF1_19129219_ChIP-ChIP_H3396_Human1.23032024
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22738198
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22143231
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.21757420
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20157832
67SPI1_23127762_ChIP-Seq_K562_Human1.19679741
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19510130
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19035265
70CIITA_25753668_ChIP-Seq_RAJI_Human1.18303713
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.18096030
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16803626
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14902198
74* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14811841
75* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14524690
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14466231
77* GATA3_26560356_Chip-Seq_TH1_Human1.13661689
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12013585
79* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11935388
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11206452
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09637533
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09072571
83* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07674325
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07159482
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06333216
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.04523897
87* ELK1_19687146_ChIP-ChIP_HELA_Human1.04402546
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.03487866
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02157160
90RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00391104
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00351711
92* VDR_23849224_ChIP-Seq_CD4+_Human0.99076595
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98860577
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98798550
95SRF_21415370_ChIP-Seq_HL-1_Mouse0.97893075
96VDR_24787735_ChIP-Seq_THP-1_Human0.97589114
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97438949
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92953744
99E2F4_17652178_ChIP-ChIP_JURKAT_Human0.92450789
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92298650
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91329424
102MYC_18940864_ChIP-ChIP_HL60_Human0.89861318
103EGR1_19032775_ChIP-ChIP_M12_Human0.89712491
104VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86594049
105STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86396868
106* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86065376
107AR_20517297_ChIP-Seq_VCAP_Human0.85848341
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85707748
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85486211
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85334333
111GATA3_21878914_ChIP-Seq_MCF-7_Human0.83140921
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82783920
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82408331
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82087192
115TP53_22573176_ChIP-Seq_HFKS_Human0.81824958
116STAT1_20625510_ChIP-Seq_HELA_Human0.81669193
117GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81440356
118CRX_20693478_ChIP-Seq_RETINA_Mouse0.80946172
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80131423
120OCT4_21477851_ChIP-Seq_ESCs_Mouse0.79639000
121EST1_17652178_ChIP-ChIP_JURKAT_Human0.79568393
122P300_27268052_Chip-Seq_Bcells_Human0.78372193
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.78157036
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.78149528
125FOXA1_25329375_ChIP-Seq_VCAP_Human0.77177717
126FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77177717
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.73112661
128FOXP3_21729870_ChIP-Seq_TREG_Human0.71868651
129KDM2B_26808549_Chip-Seq_DND41_Human0.70876286
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.70320006
131FOXM1_23109430_ChIP-Seq_U2OS_Human0.69630476
132KDM2B_26808549_Chip-Seq_SUP-B15_Human0.68488834
133ETS1_22383799_ChIP-Seq_G1ME_Mouse0.68327099
134FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.67601029
135SMRT_27268052_Chip-Seq_Bcells_Human0.60627312
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.59069140
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.58365641
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.55153402
139FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.53172275
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.52833468
141FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.52602596
142E2F1_21310950_ChIP-Seq_MCF-7_Human0.52596752
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.51005336
144GATA2_19941826_ChIP-Seq_K562_Human0.48608988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.39307566
2MP0005671_abnormal_response_to4.04931208
3MP0009785_altered_susceptibility_to3.89819478
4MP0003763_abnormal_thymus_physiology3.80934148
5MP0003724_increased_susceptibility_to3.45619569
6* MP0005000_abnormal_immune_tolerance3.43734995
7MP0002148_abnormal_hypersensitivity_rea3.38724434
8MP0000685_abnormal_immune_system3.24159472
9MP0005387_immune_system_phenotype3.21271482
10MP0001790_abnormal_immune_system3.21271482
11* MP0001800_abnormal_humoral_immune3.11873472
12MP0006082_CNS_inflammation3.05780776
13* MP0003436_decreased_susceptibility_to3.04646568
14MP0005025_abnormal_response_to2.98657724
15* MP0002723_abnormal_immune_serum2.90195253
16* MP0002452_abnormal_antigen_presenting2.79405433
17MP0003303_peritoneal_inflammation2.78447083
18* MP0001819_abnormal_immune_cell2.65736990
19* MP0002420_abnormal_adaptive_immunity2.64617955
20* MP0002419_abnormal_innate_immunity2.55094733
21MP0002405_respiratory_system_inflammati2.50913555
22MP0004510_myositis2.49941576
23MP0001853_heart_inflammation2.44792439
24* MP0002398_abnormal_bone_marrow2.36279726
25MP0009333_abnormal_splenocyte_physiolog2.33332059
26MP0002166_altered_tumor_susceptibility2.30111052
27MP0002006_tumorigenesis2.26913925
28* MP0000716_abnormal_immune_system2.17779127
29MP0010155_abnormal_intestine_physiology2.15809667
30MP0004947_skin_inflammation2.03830612
31MP0001845_abnormal_inflammatory_respons1.87348126
32MP0000689_abnormal_spleen_morphology1.86605374
33MP0001873_stomach_inflammation1.86001875
34MP0002722_abnormal_immune_system1.81697592
35MP0005464_abnormal_platelet_physiology1.80949982
36* MP0002429_abnormal_blood_cell1.76675773
37MP0002396_abnormal_hematopoietic_system1.75713085
38MP0001501_abnormal_sleep_pattern1.75317986
39MP0004808_abnormal_hematopoietic_stem1.72330159
40MP0000703_abnormal_thymus_morphology1.69521916
41* MP0001533_abnormal_skeleton_physiology1.58634080
42MP0000858_altered_metastatic_potential1.57258849
43MP0008057_abnormal_DNA_replication1.54973573
44MP0003300_gastrointestinal_ulcer1.54383015
45MP0003448_altered_tumor_morphology1.52450772
46MP0008877_abnormal_DNA_methylation1.50612256
47MP0005397_hematopoietic_system_phenotyp1.49663496
48MP0001545_abnormal_hematopoietic_system1.49663496
49MP0002876_abnormal_thyroid_physiology1.48841381
50MP0001919_abnormal_reproductive_system1.48335687
51MP0008469_abnormal_protein_level1.47567967
52MP0003866_abnormal_defecation1.46753385
53MP0005310_abnormal_salivary_gland1.43699667
54MP0009764_decreased_sensitivity_to1.42227102
55MP0006072_abnormal_retinal_apoptosis1.36936103
56MP0001986_abnormal_taste_sensitivity1.32097262
57MP0009278_abnormal_bone_marrow1.19884203
58MP0002998_abnormal_bone_remodeling1.18611368
59MP0002933_joint_inflammation1.15753669
60MP0000465_gastrointestinal_hemorrhage1.14517610
61MP0010307_abnormal_tumor_latency1.10111561
62MP0002102_abnormal_ear_morphology1.09587743
63MP0000490_abnormal_crypts_of1.07851794
64MP0008875_abnormal_xenobiotic_pharmacok0.99868879
65MP0001851_eye_inflammation0.98026903
66MP0004782_abnormal_surfactant_physiolog0.96462164
67MP0004147_increased_porphyrin_level0.95678154
68MP0008872_abnormal_physiological_respon0.94908517
69MP0002019_abnormal_tumor_incidence0.92902303
70MP0009763_increased_sensitivity_to0.91009710
71MP0003075_altered_response_to0.90373230
72MP0005166_decreased_susceptibility_to0.88358223
73MP0003252_abnormal_bile_duct0.88271883
74MP0005174_abnormal_tail_pigmentation0.87327736
75MP0002138_abnormal_hepatobiliary_system0.87223129
76MP0002277_abnormal_respiratory_mucosa0.86815374
77MP0005167_abnormal_blood-brain_barrier0.86648660
78MP0001243_abnormal_dermal_layer0.86566632
79MP0000372_irregular_coat_pigmentation0.85988034
80MP0000343_altered_response_to0.84290104
81MP0005389_reproductive_system_phenotype0.77113816
82MP0008007_abnormal_cellular_replicative0.76468983
83MP0001765_abnormal_ion_homeostasis0.75560973
84MP0001663_abnormal_digestive_system0.70507829
85* MP0005390_skeleton_phenotype0.70053078
86MP0009765_abnormal_xenobiotic_induced0.69702744
87MP0005646_abnormal_pituitary_gland0.69208760
88MP0005075_abnormal_melanosome_morpholog0.66779686
89MP0002009_preneoplasia0.66710433
90MP0003172_abnormal_lysosome_physiology0.66504620
91MP0004130_abnormal_muscle_cell0.62996671
92MP0001542_abnormal_bone_strength0.62747401
93MP0005058_abnormal_lysosome_morphology0.62738648
94MP0000013_abnormal_adipose_tissue0.62074718
95MP0001968_abnormal_touch/_nociception0.62002961
96MP0003950_abnormal_plasma_membrane0.60042752
97MP0010094_abnormal_chromosome_stability0.59988987
98MP0003795_abnormal_bone_structure0.59915042
99MP0001348_abnormal_lacrimal_gland0.59459047
100MP0000249_abnormal_blood_vessel0.59321851
101MP0001881_abnormal_mammary_gland0.59031810
102MP0005253_abnormal_eye_physiology0.58741467
103MP0003186_abnormal_redox_activity0.58302793
104MP0000230_abnormal_systemic_arterial0.57923374
105MP0004381_abnormal_hair_follicle0.57480172
106MP0003077_abnormal_cell_cycle0.57122646
107MP0000569_abnormal_digit_pigmentation0.56484362
108MP0008058_abnormal_DNA_repair0.56410934
109MP0002136_abnormal_kidney_physiology0.55540171
110MP0002693_abnormal_pancreas_physiology0.54990855
111MP0010352_gastrointestinal_tract_polyps0.54862370
112MP0004264_abnormal_extraembryonic_tissu0.54811376
113MP0008775_abnormal_heart_ventricle0.54598796
114MP0003638_abnormal_response/metabolism_0.54593227
115MP0009643_abnormal_urine_homeostasis0.54259431
116MP0008873_increased_physiological_sensi0.53798085
117MP0000604_amyloidosis0.53731798
118MP0002132_abnormal_respiratory_system0.53700518
119MP0003656_abnormal_erythrocyte_physiolo0.52573597
120MP0005645_abnormal_hypothalamus_physiol0.52216887
121MP0003045_fibrosis0.51957359
122MP0003453_abnormal_keratinocyte_physiol0.51838172
123MP0005164_abnormal_response_to0.51058915
124MP0000609_abnormal_liver_physiology0.50754183
125MP0003786_premature_aging0.50213334
126MP0004885_abnormal_endolymph0.47853404
127MP0001502_abnormal_circadian_rhythm0.45792355
128MP0005319_abnormal_enzyme/_coenzyme0.45611368
129MP0003191_abnormal_cellular_cholesterol0.45360801
130MP0003943_abnormal_hepatobiliary_system0.44475791
131MP0005076_abnormal_cell_differentiation0.43681167
132MP0000015_abnormal_ear_pigmentation0.43376425
133MP0001191_abnormal_skin_condition0.43132950
134MP0000313_abnormal_cell_death0.40459961
135MP0003828_pulmonary_edema0.40171132

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)6.00072264
2Elevated erythrocyte sedimentation rate (HP:0003565)5.94197809
3Eczematoid dermatitis (HP:0000976)5.42476061
4Stomatitis (HP:0010280)5.38314659
5Abnormality of T cell number (HP:0011839)5.02211696
6Increased IgM level (HP:0003496)4.99964006
7Recurrent abscess formation (HP:0002722)4.95481449
8T lymphocytopenia (HP:0005403)4.93513839
9Myositis (HP:0100614)4.92002259
10Retrobulbar optic neuritis (HP:0100654)4.67431774
11Optic neuritis (HP:0100653)4.67431774
12Mediastinal lymphadenopathy (HP:0100721)4.63448058
13Recurrent bacterial skin infections (HP:0005406)4.48533305
14Autoimmune thrombocytopenia (HP:0001973)4.42759233
15Orchitis (HP:0100796)4.34178498
16Recurrent fungal infections (HP:0002841)4.30928279
17Vasculitis (HP:0002633)4.27087869
18Recurrent viral infections (HP:0004429)4.18610664
19Abnormality of T cells (HP:0002843)4.01706215
20Gastrointestinal infarctions (HP:0005244)3.96556328
21Pulmonary infiltrates (HP:0002113)3.83577556
22Abnormality of the prostate (HP:0008775)3.83514504
23IgG deficiency (HP:0004315)3.81932294
24Severe combined immunodeficiency (HP:0004430)3.80510640
25Chronic otitis media (HP:0000389)3.75511737
26Recurrent bronchitis (HP:0002837)3.69247109
27Combined immunodeficiency (HP:0005387)3.63455099
28Chronic obstructive pulmonary disease (HP:0006510)3.57269164
29Obstructive lung disease (HP:0006536)3.57269164
30Chronic mucocutaneous candidiasis (HP:0002728)3.49068995
31Recurrent cutaneous fungal infections (HP:0011370)3.49068995
32Meningitis (HP:0001287)3.38406901
33Arterial thrombosis (HP:0004420)3.37957683
34Hemoptysis (HP:0002105)3.31829558
35Recurrent skin infections (HP:0001581)3.31316817
36Hypergammaglobulinemia (HP:0010702)3.20943349
37Recurrent gram-negative bacterial infections (HP:0005420)3.19243517
38Nasal polyposis (HP:0100582)3.16947662
39Abnormality of T cell physiology (HP:0011840)3.16636832
40IgM deficiency (HP:0002850)3.16516843
41Keratoconjunctivitis sicca (HP:0001097)3.12874947
42Leukocytosis (HP:0001974)3.08695005
43Thrombocytosis (HP:0001894)3.07430175
44Abnormality of eosinophils (HP:0001879)3.06365484
45IgA deficiency (HP:0002720)3.05847819
46Panhypogammaglobulinemia (HP:0003139)2.98662648
47Thyroiditis (HP:0100646)2.97736509
48Autoimmune hemolytic anemia (HP:0001890)2.96260967
49Chronic diarrhea (HP:0002028)2.93208052
50Abnormality of macrophages (HP:0004311)2.88828132
51Gingivitis (HP:0000230)2.88775496
52Keratoconjunctivitis (HP:0001096)2.84267298
53Pustule (HP:0200039)2.83118334
54Eosinophilia (HP:0001880)2.81449238
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.80045835
56Basal ganglia calcification (HP:0002135)2.78572883
57Amaurosis fugax (HP:0100576)2.76796214
58Joint swelling (HP:0001386)2.73210620
59Gangrene (HP:0100758)2.72710539
60Petechiae (HP:0000967)2.71320054
61Lymphopenia (HP:0001888)2.70802328
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.70020918
63Chest pain (HP:0100749)2.70001013
64Agammaglobulinemia (HP:0004432)2.67943722
65Conical tooth (HP:0000698)2.66691743
66Periodontitis (HP:0000704)2.64586223
67Abnormality of B cell number (HP:0010975)2.64275430
68B lymphocytopenia (HP:0010976)2.64275430
69Encephalitis (HP:0002383)2.61387561
70Abnormality of the nasal mucosa (HP:0000433)2.60709221
71Gingival bleeding (HP:0000225)2.58306357
72Abnormality of the fingertips (HP:0001211)2.57891956
73Lymphoma (HP:0002665)2.57237013
74Abnormality of the pleura (HP:0002103)2.55635993
75Renal cortical cysts (HP:0000803)2.52929756
76Congenital stationary night blindness (HP:0007642)2.52615091
77Hypoproteinemia (HP:0003075)2.47415701
78Granulocytopenia (HP:0001913)2.44755722
79Epistaxis (HP:0000421)2.42520628
80Anhidrosis (HP:0000970)2.41894990
81Abnormality of the renal cortex (HP:0011035)2.39791138
82Prostate neoplasm (HP:0100787)2.39339071
83Cellulitis (HP:0100658)2.38589588
84Anorexia (HP:0002039)2.38221000
85Recurrent sinusitis (HP:0011108)2.37466338
86Pulmonary embolism (HP:0002204)2.33287576
87Gastrointestinal stroma tumor (HP:0100723)2.25516291
88Papilloma (HP:0012740)2.21407429
89Verrucae (HP:0200043)2.21407429
90Recurrent pneumonia (HP:0006532)2.19944658
91Abnormality of the pericardium (HP:0001697)2.19581087
92Inflammation of the large intestine (HP:0002037)2.19046480
93Clumsiness (HP:0002312)2.17591778
94Gastrointestinal inflammation (HP:0004386)2.17561948
95Interstitial pulmonary disease (HP:0006530)2.17130428
96Prolonged bleeding time (HP:0003010)2.16980164
97Glomerulopathy (HP:0100820)2.15704278
98Hypoplasia of the thymus (HP:0000778)2.14645459
99Alveolar cell carcinoma (HP:0006519)2.13304433
100Purpura (HP:0000979)2.12313121
101Abnormality of male internal genitalia (HP:0000022)2.06829893
102Arthralgia (HP:0002829)2.03001517
103Skin ulcer (HP:0200042)2.01909970
104Chronic sinusitis (HP:0011109)2.00920384
105Recurrent lower respiratory tract infections (HP:0002783)1.99494465
106Cheilitis (HP:0100825)1.99458987
107Keratitis (HP:0000491)1.97067948
108Neutropenia (HP:0001875)1.96405326
109Osteomyelitis (HP:0002754)1.95861724
110Pulmonary fibrosis (HP:0002206)1.95325683
111Spontaneous hematomas (HP:0007420)1.93824183
112Urticaria (HP:0001025)1.91770271
113Fair hair (HP:0002286)1.89543983
114Bronchitis (HP:0012387)1.85732717
115Attenuation of retinal blood vessels (HP:0007843)1.82682493
116Abolished electroretinogram (ERG) (HP:0000550)1.79192921
117Neoplasm of the tracheobronchial system (HP:0100552)1.76803294
118Type 2 muscle fiber atrophy (HP:0003554)1.74267630
119Supernumerary bones of the axial skeleton (HP:0009144)1.71245843
120Pancytopenia (HP:0001876)1.69564981
121Pancreatic cysts (HP:0001737)1.68891750
122Congenital, generalized hypertrichosis (HP:0004540)1.65999503
123Skin rash (HP:0000988)1.65485845
124Xerostomia (HP:0000217)1.63945236
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61673854
126Abnormal protein N-linked glycosylation (HP:0012347)1.61673854
127Abnormal protein glycosylation (HP:0012346)1.61673854
128Abnormal glycosylation (HP:0012345)1.61673854
129Type II lissencephaly (HP:0007260)1.60408861
130Absent thumb (HP:0009777)1.57652422
131Metaphyseal dysplasia (HP:0100255)1.56978154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.51680597
2MAP4K14.68626935
3MAP3K144.33096806
4MAP2K23.62516311
5JAK33.01449078
6IKBKE2.91215875
7TYK22.72433218
8TBK12.68571520
9ITK2.67849807
10IKBKB2.52059537
11IRAK42.47359012
12ZAP702.45175942
13PIM22.40984221
14TEC2.27201599
15TLK12.13595541
16CDK82.07741366
17JAK12.06841722
18KIT2.04728147
19RIPK41.97079235
20IRAK31.88410441
21CHUK1.86222986
22BTK1.69578292
23ZAK1.68961114
24PIM11.64929502
25SYK1.62296603
26LCK1.53158811
27CSK1.50717758
28MST41.50314183
29BLK1.45795010
30FGFR41.45201859
31HCK1.42776602
32MAP3K131.41652436
33MAPKAPK31.41406126
34FGFR31.35646814
35NLK1.35216170
36STK101.32788238
37MAP4K21.31675934
38PBK1.23762521
39SIK31.19895024
40CAMKK21.19036264
41BMPR21.12974351
42BMPR1B1.11919314
43FRK1.11581786
44TAOK31.10966665
45NME21.10553340
46TESK21.09303086
47LYN1.08872049
48KDR1.05775972
49RPS6KA41.05386741
50GRK61.00116583
51JAK20.96396248
52ERBB30.93732240
53GRK10.91019860
54EIF2AK20.88220860
55MARK30.86500765
56PIK3CG0.85790261
57PIK3CA0.84607461
58WNK40.83599725
59PRKCQ0.82384068
60MAP2K30.81991010
61STK40.75675899
62MAP2K60.75268831
63MAP2K10.74111285
64NEK90.73229722
65RPS6KA50.72847507
66GRK50.72064497
67TNK20.69880432
68CLK10.69505820
69EPHB10.68829624
70MAPK70.66590252
71EPHA30.66036685
72MAP3K50.66003970
73TRPM70.65992335
74FES0.65648812
75PASK0.65506500
76TSSK60.65428853
77MAP3K120.65210405
78MAP3K100.64833442
79IRAK10.64474667
80GRK70.62895709
81SCYL20.60859434
82CAMKK10.60615102
83MAP3K110.59912192
84CSF1R0.59015611
85TGFBR20.58650968
86PINK10.55965460
87MAPK110.53995140
88ERN10.48322937
89BMX0.48153258
90CDK120.48065830
91EEF2K0.47706700
92MATK0.45679918
93BCKDK0.45286709
94ABL10.41769207
95TAOK10.41221598
96CDK40.41134423
97RAF10.39283658
98SIK20.38718135
99FLT30.38555224
100PLK40.37998365
101RPS6KA10.37813696
102PRKCD0.37693154
103STK390.37091267
104NUAK10.35929980
105STK240.35583520
106MAP3K30.34201952
107IRAK20.34159711
108PTK2B0.33901569
109LRRK20.32889542
110RPS6KC10.32594403
111RPS6KL10.32594403
112MAPKAPK20.32366634
113PLK20.32323000
114BRD40.32295256
115TAOK20.30922450
116ATR0.30569911
117RPS6KA60.30201610
118HIPK20.29658919
119IGF1R0.29105479
120ACVR1B0.28964967
121EIF2AK30.28467928
122CDK60.27564377
123NEK60.27189745
124CDK90.24995316
125MAPK40.24402595
126ADRBK20.24317892
127YES10.24167671
128DAPK10.23930911
129PRKCH0.23557017
130TGFBR10.22971434
131RPS6KB10.22351859
132DAPK20.22048841
133ABL20.20276993
134MAPK30.19417432
135EGFR0.19076533
136EIF2AK10.18566424
137INSR0.17895211
138PDK10.16733757
139FYN0.16214596

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.29530043
2Graft-versus-host disease_Homo sapiens_hsa053323.99002799
3Primary immunodeficiency_Homo sapiens_hsa053403.16708606
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.00118371
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.97044562
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.87608005
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.84295431
8Leishmaniasis_Homo sapiens_hsa051402.71299678
9Measles_Homo sapiens_hsa051622.65596101
10Autoimmune thyroid disease_Homo sapiens_hsa053202.57368410
11Type I diabetes mellitus_Homo sapiens_hsa049402.53451301
12Asthma_Homo sapiens_hsa053102.48438283
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.39559913
14T cell receptor signaling pathway_Homo sapiens_hsa046602.23244453
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.16445931
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.12140282
17Osteoclast differentiation_Homo sapiens_hsa043802.05008827
18NOD-like receptor signaling pathway_Homo sapiens_hsa046212.03147607
19Herpes simplex infection_Homo sapiens_hsa051681.92216500
20Antigen processing and presentation_Homo sapiens_hsa046121.91646385
21Legionellosis_Homo sapiens_hsa051341.88437685
22Influenza A_Homo sapiens_hsa051641.81454878
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.75788431
24TNF signaling pathway_Homo sapiens_hsa046681.73046781
25Hematopoietic cell lineage_Homo sapiens_hsa046401.72488627
26Malaria_Homo sapiens_hsa051441.71098146
27Toxoplasmosis_Homo sapiens_hsa051451.56475454
28B cell receptor signaling pathway_Homo sapiens_hsa046621.52081709
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51127728
30Viral myocarditis_Homo sapiens_hsa054161.47239430
31Rheumatoid arthritis_Homo sapiens_hsa053231.46790169
32Pertussis_Homo sapiens_hsa051331.42082911
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37844114
34African trypanosomiasis_Homo sapiens_hsa051431.36125252
35Nitrogen metabolism_Homo sapiens_hsa009101.35438779
36Caffeine metabolism_Homo sapiens_hsa002321.34745617
37Staphylococcus aureus infection_Homo sapiens_hsa051501.33751655
38Tuberculosis_Homo sapiens_hsa051521.30528832
39Hepatitis B_Homo sapiens_hsa051611.30127251
40Linoleic acid metabolism_Homo sapiens_hsa005911.24038820
41Chemokine signaling pathway_Homo sapiens_hsa040621.18756650
42Apoptosis_Homo sapiens_hsa042101.15569932
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14786696
44Salmonella infection_Homo sapiens_hsa051321.08154384
45Phototransduction_Homo sapiens_hsa047441.06807288
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03958190
47Acute myeloid leukemia_Homo sapiens_hsa052211.01206836
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00545117
49Shigellosis_Homo sapiens_hsa051311.00190283
50Hepatitis C_Homo sapiens_hsa051600.96352438
51Epstein-Barr virus infection_Homo sapiens_hsa051690.87039586
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80571948
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80070067
54Arachidonic acid metabolism_Homo sapiens_hsa005900.79329269
55Prolactin signaling pathway_Homo sapiens_hsa049170.77855813
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75339831
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74229928
58HTLV-I infection_Homo sapiens_hsa051660.72358115
59Viral carcinogenesis_Homo sapiens_hsa052030.67069942
60Base excision repair_Homo sapiens_hsa034100.66143707
61Chronic myeloid leukemia_Homo sapiens_hsa052200.64750203
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.63791932
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59253495
64Regulation of autophagy_Homo sapiens_hsa041400.55717758
65Small cell lung cancer_Homo sapiens_hsa052220.55181192
66p53 signaling pathway_Homo sapiens_hsa041150.53563933
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52598092
68DNA replication_Homo sapiens_hsa030300.52320158
69Pancreatic cancer_Homo sapiens_hsa052120.51726693
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51102422
71Platelet activation_Homo sapiens_hsa046110.50494840
72Ether lipid metabolism_Homo sapiens_hsa005650.49755914
73Basal transcription factors_Homo sapiens_hsa030220.47660242
74Non-homologous end-joining_Homo sapiens_hsa034500.47620255
75Renin secretion_Homo sapiens_hsa049240.45477927
76Protein export_Homo sapiens_hsa030600.44346726
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43585703
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42901260
79RNA degradation_Homo sapiens_hsa030180.41391070
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.41098608
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40548179
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38980584
83Systemic lupus erythematosus_Homo sapiens_hsa053220.38768128
84Amoebiasis_Homo sapiens_hsa051460.38218538
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.37885790
86Phagosome_Homo sapiens_hsa041450.36656096
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36246333
88Ribosome_Homo sapiens_hsa030100.35624807
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34942137
90Proteasome_Homo sapiens_hsa030500.33372032
91Olfactory transduction_Homo sapiens_hsa047400.31599899
92Chemical carcinogenesis_Homo sapiens_hsa052040.31220392
93Mismatch repair_Homo sapiens_hsa034300.30380658
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29744497
95Tryptophan metabolism_Homo sapiens_hsa003800.29224630
96Circadian rhythm_Homo sapiens_hsa047100.28474549
97HIF-1 signaling pathway_Homo sapiens_hsa040660.26739187
98Morphine addiction_Homo sapiens_hsa050320.26708021
99Selenocompound metabolism_Homo sapiens_hsa004500.26539985
100Homologous recombination_Homo sapiens_hsa034400.26338220
101MAPK signaling pathway_Homo sapiens_hsa040100.25946310
102Purine metabolism_Homo sapiens_hsa002300.25658066
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25542204
104Spliceosome_Homo sapiens_hsa030400.25281403
105Lysosome_Homo sapiens_hsa041420.24077979
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22561566
107FoxO signaling pathway_Homo sapiens_hsa040680.22264837
108Other glycan degradation_Homo sapiens_hsa005110.21735241
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.21725861
110MicroRNAs in cancer_Homo sapiens_hsa052060.21221900
111Notch signaling pathway_Homo sapiens_hsa043300.20580181
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20073085
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.19546814
114Salivary secretion_Homo sapiens_hsa049700.17687796
115ABC transporters_Homo sapiens_hsa020100.16881918
116Serotonergic synapse_Homo sapiens_hsa047260.16823279
117Fanconi anemia pathway_Homo sapiens_hsa034600.16528824
118Colorectal cancer_Homo sapiens_hsa052100.15680582
119Glycerolipid metabolism_Homo sapiens_hsa005610.15340125
120VEGF signaling pathway_Homo sapiens_hsa043700.15155094
121One carbon pool by folate_Homo sapiens_hsa006700.15091512
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.14576486
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13711485
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13647080
125Pyrimidine metabolism_Homo sapiens_hsa002400.13567712
126Taste transduction_Homo sapiens_hsa047420.13492482
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.13401061
128Prion diseases_Homo sapiens_hsa050200.13061075
129Retinol metabolism_Homo sapiens_hsa008300.12413516
130Amphetamine addiction_Homo sapiens_hsa050310.12168025
131Thyroid cancer_Homo sapiens_hsa052160.08761397
132RNA polymerase_Homo sapiens_hsa030200.08344302
133Non-small cell lung cancer_Homo sapiens_hsa052230.08034036
134Prostate cancer_Homo sapiens_hsa052150.07901520

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