CD70

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)9.91481240
2positive regulation of T-helper cell differentiation (GO:0045624)8.44377933
3regulation of activation of Janus kinase activity (GO:0010533)7.34183889
4regulation of T-helper 2 cell differentiation (GO:0045628)7.15299229
5positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)6.88198041
6regulation of memory T cell differentiation (GO:0043380)6.78536874
7positive regulation of alpha-beta T cell proliferation (GO:0046641)6.76762687
8regulation of T-helper cell differentiation (GO:0045622)6.60137206
9positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)6.46785641
10positive regulation of interleukin-12 production (GO:0032735)6.16327840
11cytidine deamination (GO:0009972)6.10305725
12cytidine metabolic process (GO:0046087)6.10305725
13cytidine catabolic process (GO:0006216)6.10305725
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.05989695
15positive regulation of type 2 immune response (GO:0002830)6.04431460
16regulation of alpha-beta T cell proliferation (GO:0046640)5.95770388
17positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)5.88154493
18regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.83099288
19regulation of dendritic cell antigen processing and presentation (GO:0002604)5.71712661
20T-helper 1 type immune response (GO:0042088)5.69105405
21regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)5.50831780
22pyrimidine ribonucleoside catabolic process (GO:0046133)5.36986657
23regulation of T-helper 1 type immune response (GO:0002825)5.36334518
24positive regulation of natural killer cell differentiation (GO:0032825)5.33134841
25positive regulation of T-helper 1 type immune response (GO:0002827)5.20453574
26regulation of B cell receptor signaling pathway (GO:0050855)5.19653553
27positive regulation of activated T cell proliferation (GO:0042104)5.12290667
28CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.12264988
29regulation of immunoglobulin secretion (GO:0051023)5.09549692
30B cell receptor signaling pathway (GO:0050853)5.06303376
31positive regulation of interleukin-17 production (GO:0032740)4.96956202
32negative regulation of B cell proliferation (GO:0030889)4.93602324
33regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)4.87868352
34positive regulation of interleukin-2 production (GO:0032743)4.87444721
35myeloid dendritic cell differentiation (GO:0043011)4.65255172
36regulation of hypersensitivity (GO:0002883)4.64510658
37negative regulation of interleukin-17 production (GO:0032700)4.58927644
38response to prostaglandin E (GO:0034695)4.58870533
39regulation of T cell tolerance induction (GO:0002664)4.53339512
40regulation of interleukin-17 production (GO:0032660)4.47732131
41neutrophil activation involved in immune response (GO:0002283)4.47109161
42negative thymic T cell selection (GO:0045060)4.46660237
43natural killer cell differentiation (GO:0001779)4.42802381
44antigen processing and presentation of endogenous antigen (GO:0019883)4.42440424
45positive regulation of antigen processing and presentation (GO:0002579)4.39597035
46regulation of interleukin-12 production (GO:0032655)4.38775335
47T cell migration (GO:0072678)4.35953584
48positive regulation of T cell cytokine production (GO:0002726)4.34707498
49DNA deamination (GO:0045006)4.33335920
50B cell homeostasis (GO:0001782)4.27568684
51immunoglobulin mediated immune response (GO:0016064)4.26618041
52response to muramyl dipeptide (GO:0032495)4.21691032
53negative T cell selection (GO:0043383)4.17405194
54regulation of interleukin-12 biosynthetic process (GO:0045075)4.07959799
55positive regulation of B cell differentiation (GO:0045579)4.06663616
56T cell lineage commitment (GO:0002360)4.05982634
57positive regulation of alpha-beta T cell differentiation (GO:0046638)4.05680539
58regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.05344232
59regulation of interleukin-2 biosynthetic process (GO:0045076)4.05082429
60neutrophil activation (GO:0042119)4.02466390
61myeloid dendritic cell activation (GO:0001773)4.00101130
62cellular response to zinc ion (GO:0071294)3.99738342
63regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.95488364
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.92810135
65antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.92810135
66cellular response to interleukin-15 (GO:0071350)3.89276575
67regulation of antigen processing and presentation (GO:0002577)3.83796234
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.83327618
69positive regulation of humoral immune response (GO:0002922)3.83254530
70type I interferon signaling pathway (GO:0060337)3.83057527
71cellular response to type I interferon (GO:0071357)3.83057527
72negative regulation of T-helper cell differentiation (GO:0045623)3.82894779
73negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.82894779
74B cell mediated immunity (GO:0019724)3.81563351
75positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.81462415
76granulocyte activation (GO:0036230)3.78128555
77growth hormone receptor signaling pathway (GO:0060396)3.77274399
78response to type I interferon (GO:0034340)3.74196556
79regulation of activated T cell proliferation (GO:0046006)3.74103777
80T cell costimulation (GO:0031295)3.73269678
81regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.70442021
82positive regulation of T cell proliferation (GO:0042102)3.70134949
83positive regulation of pseudopodium assembly (GO:0031274)3.70084717
84regulation of RIG-I signaling pathway (GO:0039535)3.69159141
85lymphocyte costimulation (GO:0031294)3.67937754
86dendritic cell differentiation (GO:0097028)3.65151796
87regulation of alpha-beta T cell differentiation (GO:0046637)3.63454526
88positive regulation of gamma-delta T cell activation (GO:0046645)3.61922887
89positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.57622361
90positive regulation of interferon-alpha production (GO:0032727)3.57339754
91NIK/NF-kappaB signaling (GO:0038061)3.57242104
92natural killer cell activation (GO:0030101)3.55127183
93regulation of natural killer cell differentiation (GO:0032823)3.53508722
94response to prostaglandin (GO:0034694)3.50936674
95regulation of B cell differentiation (GO:0045577)3.50369354
96response to peptidoglycan (GO:0032494)3.49709637
97positive thymic T cell selection (GO:0045059)3.49144490
98B cell proliferation (GO:0042100)3.48666974
99regulation of B cell proliferation (GO:0030888)3.47777036
100natural killer cell mediated cytotoxicity (GO:0042267)3.46075422
101natural killer cell mediated immunity (GO:0002228)3.46075422
102positive regulation of isotype switching (GO:0045830)3.45242681
103positive regulation of interleukin-10 production (GO:0032733)3.43084956
104regulation of interferon-gamma biosynthetic process (GO:0045072)3.42461437
105negative regulation of viral genome replication (GO:0045071)3.39991178
106thymic T cell selection (GO:0045061)3.39204642
107regulation of tolerance induction (GO:0002643)3.38210954
108myeloid leukocyte mediated immunity (GO:0002444)3.38169182
109negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.38118529
110positive regulation of protein homooligomerization (GO:0032464)3.37236805
111positive regulation of interleukin-4 production (GO:0032753)3.36957818
112positive regulation of alpha-beta T cell activation (GO:0046635)3.36884838
113regulation of pseudopodium assembly (GO:0031272)3.35515512
114regulation of protein heterodimerization activity (GO:0043497)3.33306457
115regulation of regulatory T cell differentiation (GO:0045589)3.32687038
116regulation of interferon-alpha production (GO:0032647)3.32677914
117regulation of type 2 immune response (GO:0002828)3.32432180
118regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.31953393
119dendritic cell chemotaxis (GO:0002407)3.28864785
120striated muscle atrophy (GO:0014891)3.27482915
121positive regulation of response to tumor cell (GO:0002836)3.27393937
122positive regulation of immune response to tumor cell (GO:0002839)3.27393937
123regulation of immune response to tumor cell (GO:0002837)3.27393937
124regulation of response to tumor cell (GO:0002834)3.27393937
125response to interleukin-15 (GO:0070672)3.24951322
126gonadal mesoderm development (GO:0007506)3.22979676
127positive regulation of monocyte chemotaxis (GO:0090026)3.21713297
128positive regulation of lymphocyte proliferation (GO:0050671)3.19765068
129cellular response to growth hormone stimulus (GO:0071378)3.19233693
130interferon-gamma-mediated signaling pathway (GO:0060333)3.18771219
131activation of MAPKKK activity (GO:0000185)3.17361677
132positive regulation of mononuclear cell proliferation (GO:0032946)3.16518236
133monocyte chemotaxis (GO:0002548)3.14504294
134positive regulation of protein oligomerization (GO:0032461)3.10886623
135antigen receptor-mediated signaling pathway (GO:0050851)2.95877231
136regulation of interferon-beta biosynthetic process (GO:0045357)2.95418748
137cellular response to interferon-gamma (GO:0071346)2.94266386
138positive regulation of defense response to virus by host (GO:0002230)2.94124659
139regulation of B cell apoptotic process (GO:0002902)2.91909294
140negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.86362883
141regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.86034840
142ribosomal small subunit biogenesis (GO:0042274)2.83905120
143cellular response to interferon-beta (GO:0035458)2.83420320
144negative regulation of B cell activation (GO:0050869)2.82886104
145positive regulation of B cell mediated immunity (GO:0002714)2.81292161
146positive regulation of immunoglobulin mediated immune response (GO:0002891)2.81292161
147positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80767643
148lymphocyte homeostasis (GO:0002260)2.80453204
149positive regulation by symbiont of host defense response (GO:0052509)2.80012882
150modulation by symbiont of host defense response (GO:0052031)2.80012882
151modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.80012882
152modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.80012882
153positive regulation by organism of defense response of other organism involved in symbiotic interact2.80012882
154modulation by symbiont of host immune response (GO:0052553)2.80012882
155positive regulation of interferon-gamma production (GO:0032729)2.79895700
156positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.76143804
157negative regulation of B cell apoptotic process (GO:0002903)2.76120866
158regulation of B cell activation (GO:0050864)2.74481562
159detection of bacterium (GO:0016045)2.74441042
160Arp2/3 complex-mediated actin nucleation (GO:0034314)2.72675886
161negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.72153268
162regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72137277
163positive regulation of cell killing (GO:0031343)2.71507187
164positive regulation of lymphocyte migration (GO:2000403)2.68184722
165T cell apoptotic process (GO:0070231)2.66637226
166regulation of lymphocyte migration (GO:2000401)2.66471825
167positive regulation of B cell proliferation (GO:0030890)2.66392177
168regulation of lymphocyte chemotaxis (GO:1901623)2.66190504
169adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.65423529
170positive regulation of lymphocyte apoptotic process (GO:0070230)2.63781765
171positive T cell selection (GO:0043368)2.63289158
172regulation of viral genome replication (GO:0045069)2.63246618
173positive regulation of B cell activation (GO:0050871)2.63094385
174positive regulation of cytokine biosynthetic process (GO:0042108)2.61016326
175mature B cell differentiation (GO:0002335)2.56909526
176negative regulation of myeloid cell apoptotic process (GO:0033033)2.55232957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.05727111
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.18627125
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.93768483
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.29181168
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.19901777
6E2F7_22180533_ChIP-Seq_HELA_Human3.98090110
7* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.85545995
8MYC_22102868_ChIP-Seq_BL_Human3.84064076
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.61250727
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51895450
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.43475604
12TP63_17297297_ChIP-ChIP_HaCaT_Human3.37198876
13IRF8_27001747_Chip-Seq_BMDM_Mouse3.32621628
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.09687361
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.07784659
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.81370983
17* VDR_21846776_ChIP-Seq_THP-1_Human2.76714898
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67235448
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66563842
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57532299
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.55161120
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53628905
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46425966
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.31869273
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31144508
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27014571
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.25245685
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.24904482
29CIITA_25753668_ChIP-Seq_RAJI_Human2.23362420
30VDR_24787735_ChIP-Seq_THP-1_Human2.12602102
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.06320032
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04851511
33MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01941373
34EGR1_19032775_ChIP-ChIP_M12_Human1.99154471
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.96519288
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88595425
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87155260
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85924217
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83868217
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80580520
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79882541
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78729560
43RUNX_20019798_ChIP-Seq_JUKART_Human1.78715164
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77123827
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75836631
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74306458
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73903055
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73829468
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73604805
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.70923648
51UTX_26944678_Chip-Seq_JUKART_Human1.67780395
52HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.63571707
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62878168
54MYB_26560356_Chip-Seq_TH2_Human1.59886868
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58834398
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57685497
57XRN2_22483619_ChIP-Seq_HELA_Human1.57221250
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57004729
59DCP1A_22483619_ChIP-Seq_HELA_Human1.56556422
60MAF_26560356_Chip-Seq_TH1_Human1.54021571
61GATA1_22025678_ChIP-Seq_K562_Human1.52293724
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50351929
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49242418
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48623827
65* ETS1_20019798_ChIP-Seq_JURKAT_Human1.48440381
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47967704
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47402331
68VDR_23849224_ChIP-Seq_CD4+_Human1.45847423
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41905848
70LXR_22292898_ChIP-Seq_THP-1_Human1.41673178
71FOXP3_21729870_ChIP-Seq_TREG_Human1.41373515
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40805762
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35685799
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35514461
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.34106685
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32582887
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30232655
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29557955
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28412429
80MYB_26560356_Chip-Seq_TH1_Human1.27238495
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.25272539
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23732721
83CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23628873
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23406103
85GATA3_26560356_Chip-Seq_TH2_Human1.23148043
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23066230
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.22891353
88ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22408514
89PU_27001747_Chip-Seq_BMDM_Mouse1.22182359
90TFEB_21752829_ChIP-Seq_HELA_Human1.21663351
91SPI1_23547873_ChIP-Seq_NB4_Human1.19770979
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19010947
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.17486820
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16749382
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16531426
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.14874522
97ELK3_25401928_ChIP-Seq_HUVEC_Human1.13468698
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13436093
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11126918
100E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10935142
101TCF7_22412390_ChIP-Seq_EML_Mouse1.10356120
102GATA3_27048872_Chip-Seq_THYMUS_Human1.09366628
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08682708
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07412160
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07123987
106SPI1_23127762_ChIP-Seq_K562_Human1.06437520
107VDR_24763502_ChIP-Seq_THP-1_Human1.05786979
108GABP_19822575_ChIP-Seq_HepG2_Human1.05458354
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05345186
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05066579
111TTF2_22483619_ChIP-Seq_HELA_Human1.03384431
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02976056
113SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01535830
114KDM2B_26808549_Chip-Seq_DND41_Human1.00961058
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00939987
116GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00571202
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99986816
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99986816
119* SMRT_27268052_Chip-Seq_Bcells_Human0.98286029
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95667970
121IGF1R_20145208_ChIP-Seq_DFB_Human0.95109458
122CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93703253
123TP53_18474530_ChIP-ChIP_U2OS_Human0.93357308
124IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93102122
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90845624
126BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89975887
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.88690824
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87179446
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85441609
130KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.85073025
131SOX2_20726797_ChIP-Seq_SW620_Human0.84123517
132CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84086529
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83698087
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83553980
135* MAF_26560356_Chip-Seq_TH2_Human0.78709408
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.78472887
137FLI1_27457419_Chip-Seq_LIVER_Mouse0.78143790
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.75603421
139EGR1_23403033_ChIP-Seq_LIVER_Mouse0.74289670
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.74227440
141NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.72515649
142ZNF263_19887448_ChIP-Seq_K562_Human0.71824669
143SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.71280086
144SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.71280086
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70844287
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.66940573
147LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.62360173
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.62142959
149PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.60474474
150P300_19829295_ChIP-Seq_ESCs_Human0.59494771
151SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.57130286
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.57103769
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.56556042
154TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.56069027
155* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.54817916
156GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.54741606
157CDX2_22108803_ChIP-Seq_LS180_Human0.54530177
158RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.53530132
159FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.53433788
160* CJUN_26792858_Chip-Seq_BT549_Human0.52889748
161PCGF2_27294783_Chip-Seq_ESCs_Mouse0.52633599
162PU1_27457419_Chip-Seq_LIVER_Mouse0.51250550
163NMYC_18555785_Chip-Seq_ESCs_Mouse0.50873185
164ZFP57_27257070_Chip-Seq_ESCs_Mouse0.50763441
165TCF4_18268006_ChIP-ChIP_LS174T_Human0.50533692
166GATA1_19941827_ChIP-Seq_MEL_Mouse0.49486570
167* TP63_23658742_ChIP-Seq_EP156T_Human0.49407597
168P63_26484246_Chip-Seq_KERATINOCYTES_Human0.49129550
169OCT4_21477851_ChIP-Seq_ESCs_Mouse0.49067465
170PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.48687232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.63620955
2MP0001348_abnormal_lacrimal_gland5.57772620
3MP0002163_abnormal_gland_morphology4.99343391
4MP0000685_abnormal_immune_system4.96190085
5MP0001346_abnormal_lacrimal_gland4.81799675
6MP0005671_abnormal_response_to3.90743530
7MP0002148_abnormal_hypersensitivity_rea3.90241081
8MP0002138_abnormal_hepatobiliary_system3.80835224
9MP0009785_altered_susceptibility_to3.74251813
10MP0005387_immune_system_phenotype3.53511737
11MP0001790_abnormal_immune_system3.53511737
12MP0005623_abnormal_meninges_morphology3.17433574
13MP0005000_abnormal_immune_tolerance3.01961565
14MP0005379_endocrine/exocrine_gland_phen2.91484663
15MP0003436_decreased_susceptibility_to2.80098045
16MP0004510_myositis2.57274132
17MP0005645_abnormal_hypothalamus_physiol2.54570076
18MP0005310_abnormal_salivary_gland2.53665305
19MP0001800_abnormal_humoral_immune2.45876148
20MP0005025_abnormal_response_to2.44649143
21MP0002166_altered_tumor_susceptibility2.36218914
22MP0002723_abnormal_immune_serum2.33098802
23MP0002452_abnormal_antigen_presenting2.21519861
24MP0002006_tumorigenesis2.11791203
25MP0003111_abnormal_nucleus_morphology2.11752380
26MP0001819_abnormal_immune_cell2.06210613
27MP0010094_abnormal_chromosome_stability2.05962951
28MP0002254_reproductive_system_inflammat2.00803135
29MP0002420_abnormal_adaptive_immunity1.98860057
30MP0006082_CNS_inflammation1.97940290
31MP0002419_abnormal_innate_immunity1.89256851
32MP0001853_heart_inflammation1.74739269
33MP0005451_abnormal_body_composition1.70216146
34MP0003077_abnormal_cell_cycle1.70080660
35MP0003693_abnormal_embryo_hatching1.66791364
36MP0005076_abnormal_cell_differentiation1.62707635
37MP0000716_abnormal_immune_system1.56600266
38MP0003045_fibrosis1.50752495
39MP0002398_abnormal_bone_marrow1.49398541
40MP0010307_abnormal_tumor_latency1.46600718
41MP0002277_abnormal_respiratory_mucosa1.41011570
42MP0003724_increased_susceptibility_to1.37759778
43MP0001845_abnormal_inflammatory_respons1.35384316
44MP0002876_abnormal_thyroid_physiology1.32213777
45MP0010155_abnormal_intestine_physiology1.31661951
46MP0008057_abnormal_DNA_replication1.31608479
47MP0009764_decreased_sensitivity_to1.25278137
48MP0000613_abnormal_salivary_gland1.22234299
49MP0003091_abnormal_cell_migration1.21710899
50MP0003303_peritoneal_inflammation1.19717893
51MP0008007_abnormal_cellular_replicative1.19477153
52MP0004957_abnormal_blastocyst_morpholog1.18173250
53MP0008469_abnormal_protein_level1.17967170
54MP0002429_abnormal_blood_cell1.12036170
55MP0000350_abnormal_cell_proliferation1.10259088
56MP0003763_abnormal_thymus_physiology1.09767877
57MP0002396_abnormal_hematopoietic_system1.09526629
58MP0002405_respiratory_system_inflammati1.09498770
59MP0003786_premature_aging1.09244672
60MP0001533_abnormal_skeleton_physiology1.07871000
61MP0000490_abnormal_crypts_of1.06506583
62MP0005084_abnormal_gallbladder_morpholo1.05984380
63MP0002009_preneoplasia1.00837638
64MP0000313_abnormal_cell_death0.99339233
65MP0004947_skin_inflammation0.97976734
66MP0003183_abnormal_peptide_metabolism0.94904356
67MP0002877_abnormal_melanocyte_morpholog0.94622872
68MP0008058_abnormal_DNA_repair0.92335527
69MP0002722_abnormal_immune_system0.88933990
70MP0010234_abnormal_vibrissa_follicle0.87586290
71MP0001919_abnormal_reproductive_system0.86618092
72MP0000689_abnormal_spleen_morphology0.85936853
73MP0001727_abnormal_embryo_implantation0.83879766
74MP0000372_irregular_coat_pigmentation0.80927767
75MP0005397_hematopoietic_system_phenotyp0.80721944
76MP0001545_abnormal_hematopoietic_system0.80721944
77MP0001881_abnormal_mammary_gland0.79174784
78MP0003191_abnormal_cellular_cholesterol0.78189174
79MP0009840_abnormal_foam_cell0.77958094
80MP0000371_diluted_coat_color0.76503753
81MP0003448_altered_tumor_morphology0.76305453
82MP0000358_abnormal_cell_content/0.75343322
83MP0006035_abnormal_mitochondrial_morpho0.71819079
84MP0001661_extended_life_span0.70411856
85MP0003075_altered_response_to0.69898741
86MP0002139_abnormal_hepatobiliary_system0.69791491
87MP0005464_abnormal_platelet_physiology0.69137613
88MP0005621_abnormal_cell_physiology0.67066411
89MP0002693_abnormal_pancreas_physiology0.66562825
90MP0002928_abnormal_bile_duct0.65142807
91MP0001730_embryonic_growth_arrest0.64283849
92MP0002933_joint_inflammation0.63326558
93MP0002136_abnormal_kidney_physiology0.62643202
94MP0003959_abnormal_lean_body0.62425968
95MP0000733_abnormal_muscle_development0.62291551
96MP0000003_abnormal_adipose_tissue0.62231457
97MP0003453_abnormal_keratinocyte_physiol0.61330596
98MP0005220_abnormal_exocrine_pancreas0.61308664
99MP0000858_altered_metastatic_potential0.60890127
100MP0009763_increased_sensitivity_to0.60228061
101MP0003252_abnormal_bile_duct0.59196378
102MP0000703_abnormal_thymus_morphology0.58061761
103MP0005384_cellular_phenotype0.57423453
104MP0001915_intracranial_hemorrhage0.57264177
105MP0000627_abnormal_mammary_gland0.56269645
106MP0009333_abnormal_splenocyte_physiolog0.56065151
107MP0000015_abnormal_ear_pigmentation0.53469637
108MP0003172_abnormal_lysosome_physiology0.53276991
109MP0009115_abnormal_fat_cell0.52897122
110MP0004381_abnormal_hair_follicle0.52668982
111MP0002083_premature_death0.52150430
112MP0000609_abnormal_liver_physiology0.51572350
113MP0005584_abnormal_enzyme/coenzyme_acti0.51074076
114MP0005075_abnormal_melanosome_morpholog0.50243289
115MP0000249_abnormal_blood_vessel0.50208285
116MP0010386_abnormal_urinary_bladder0.49908220
117MP0009643_abnormal_urine_homeostasis0.49053600
118MP0004782_abnormal_surfactant_physiolog0.47599916
119MP0005501_abnormal_skin_physiology0.46923415
120MP0002998_abnormal_bone_remodeling0.46891876
121MP0003566_abnormal_cell_adhesion0.43545048
122MP0001986_abnormal_taste_sensitivity0.43507440
123MP0009765_abnormal_xenobiotic_induced0.42746376
124MP0003943_abnormal_hepatobiliary_system0.41272753
125MP0008872_abnormal_physiological_respon0.38529980
126MP0000767_abnormal_smooth_muscle0.35901241
127MP0001873_stomach_inflammation0.35236092
128MP0005423_abnormal_somatic_nervous0.34601615
129MP0005390_skeleton_phenotype0.34081654
130MP0003186_abnormal_redox_activity0.31060196
131MP0004808_abnormal_hematopoietic_stem0.30116472
132MP0003866_abnormal_defecation0.29503743
133MP0009278_abnormal_bone_marrow0.29301415
134MP0000920_abnormal_myelination0.28482753
135MP0003300_gastrointestinal_ulcer0.26688197
136MP0002019_abnormal_tumor_incidence0.25311667
137MP0008874_decreased_physiological_sensi0.24052247
138MP0000470_abnormal_stomach_morphology0.23676135
139MP0001502_abnormal_circadian_rhythm0.23556637
140MP0001984_abnormal_olfaction0.23462935

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)9.26253122
2Gastrointestinal stroma tumor (HP:0100723)7.38700703
3Optic neuritis (HP:0100653)7.05709485
4Retrobulbar optic neuritis (HP:0100654)7.05709485
5Orchitis (HP:0100796)6.24847650
6Myositis (HP:0100614)5.89066237
7Recurrent sinusitis (HP:0011108)5.69054297
8IgM deficiency (HP:0002850)5.63414348
9Autoimmune thrombocytopenia (HP:0001973)5.59546953
10Lymphopenia (HP:0001888)4.89030572
11Elevated erythrocyte sedimentation rate (HP:0003565)4.82882632
12Recurrent bacterial skin infections (HP:0005406)4.60993538
13Vasculitis (HP:0002633)4.60342176
14Chronic otitis media (HP:0000389)4.52785041
15Eczematoid dermatitis (HP:0000976)4.52439888
16Gastrointestinal infarctions (HP:0005244)4.48004681
17Hypergammaglobulinemia (HP:0010702)4.45746741
18Keratoconjunctivitis (HP:0001096)4.35910197
19Squamous cell carcinoma (HP:0002860)4.34217304
20Keratoconjunctivitis sicca (HP:0001097)4.31593807
21Recurrent abscess formation (HP:0002722)4.12616111
22Emphysema (HP:0002097)4.08069253
23Hypochromic anemia (HP:0001931)4.05282750
24Tetraparesis (HP:0002273)3.92838733
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.91647501
26Abnormality of T cell number (HP:0011839)3.81547263
27Pulmonary infiltrates (HP:0002113)3.79525543
28Chronic diarrhea (HP:0002028)3.76485051
29Nasal polyposis (HP:0100582)3.68555040
30Recurrent fungal infections (HP:0002841)3.66667170
31Hydroxyprolinuria (HP:0003080)3.59081938
32Abnormality of proline metabolism (HP:0010907)3.59081938
33Arterial thrombosis (HP:0004420)3.56358619
34Recurrent gram-negative bacterial infections (HP:0005420)3.50437284
35Restrictive lung disease (HP:0002091)3.45946321
36Colitis (HP:0002583)3.40189604
37Autoimmune hemolytic anemia (HP:0001890)3.40180652
38Abnormality of the prostate (HP:0008775)3.33364598
39Eosinophilia (HP:0001880)3.27966184
40Lymphoma (HP:0002665)3.23206682
41Chronic sinusitis (HP:0011109)3.17310503
42Basal ganglia calcification (HP:0002135)3.13700092
43Abnormality of macrophages (HP:0004311)3.13160945
44Joint swelling (HP:0001386)3.13077718
45Recurrent skin infections (HP:0001581)3.11145632
46Vertebral compression fractures (HP:0002953)3.09060705
47Mediastinal lymphadenopathy (HP:0100721)3.06993757
48B lymphocytopenia (HP:0010976)3.02793535
49Bronchitis (HP:0012387)2.98637328
50Basal cell carcinoma (HP:0002671)2.97854288
51Ureteral stenosis (HP:0000071)2.97380543
52Abnormality of the nasal mucosa (HP:0000433)2.96697018
53Anorexia (HP:0002039)2.96425122
54Skin rash (HP:0000988)2.96203029
55Encephalitis (HP:0002383)2.96092066
56Porencephaly (HP:0002132)2.94520469
57Panhypogammaglobulinemia (HP:0003139)2.93426781
58Granulocytopenia (HP:0001913)2.90824327
59Recurrent viral infections (HP:0004429)2.86371262
60Hemoptysis (HP:0002105)2.84295494
61Abnormality of B cell number (HP:0010975)2.83447383
62Recurrent otitis media (HP:0000403)2.82098814
63Ureteral obstruction (HP:0006000)2.81719894
64Papilloma (HP:0012740)2.79617350
65Verrucae (HP:0200043)2.79617350
66Recurrent bronchitis (HP:0002837)2.78216178
67Gangrene (HP:0100758)2.78169382
68Gingival bleeding (HP:0000225)2.75225469
69Urticaria (HP:0001025)2.75036343
70Entropion (HP:0000621)2.73516461
71Abnormality of eosinophils (HP:0001879)2.73495823
72Dry hair (HP:0011359)2.70534422
73Chronic mucocutaneous candidiasis (HP:0002728)2.69698405
74Recurrent cutaneous fungal infections (HP:0011370)2.69698405
75Leukopenia (HP:0001882)2.69281288
76Meningitis (HP:0001287)2.67448141
77Poikiloderma (HP:0001029)2.62978768
78Cerebral ischemia (HP:0002637)2.61696001
79Gastrointestinal inflammation (HP:0004386)2.60919539
80Agammaglobulinemia (HP:0004432)2.59830986
81Inflammation of the large intestine (HP:0002037)2.58275312
82Amyloidosis (HP:0011034)2.55555695
83Pulmonary fibrosis (HP:0002206)2.53671628
84IgG deficiency (HP:0004315)2.52159943
85Pulmonary embolism (HP:0002204)2.50756491
86Onycholysis (HP:0001806)2.50405062
87Leukocytosis (HP:0001974)2.49463468
88IgA deficiency (HP:0002720)2.48137805
89Abnormality of glutamine family amino acid metabolism (HP:0010902)2.48057784
90Thrombocytosis (HP:0001894)2.43009011
91Periodontitis (HP:0000704)2.40916021
92Abnormality of T cell physiology (HP:0011840)2.39222449
93Osteomyelitis (HP:0002754)2.39039035
94Abnormality of T cells (HP:0002843)2.37003869
95Anhidrosis (HP:0000970)2.35810530
96Abnormality of the fingertips (HP:0001211)2.35774854
97T lymphocytopenia (HP:0005403)2.35456567
98Abnormality of male internal genitalia (HP:0000022)2.32324982
99Memory impairment (HP:0002354)2.31447113
100Hypertensive crisis (HP:0100735)2.27867743
101Cellulitis (HP:0100658)2.24529655
102Alveolar cell carcinoma (HP:0006519)2.23985643
103Systemic lupus erythematosus (HP:0002725)2.22773184
104Viral hepatitis (HP:0006562)2.22743030
105Cutaneous melanoma (HP:0012056)2.20946471
106Osteolytic defects of the hand bones (HP:0009699)2.20511332
107Osteolytic defects of the phalanges of the hand (HP:0009771)2.20511332
108Abnormality of the pericardium (HP:0001697)2.20093067
109Increased IgE level (HP:0003212)2.20009851
110Abnormality of the pleura (HP:0002103)2.16646155
111Cleft eyelid (HP:0000625)2.15352306
112Premature loss of primary teeth (HP:0006323)2.12338061
113Aplastic anemia (HP:0001915)2.12078856
114Purpura (HP:0000979)2.11682065
115Sepsis (HP:0100806)2.09930748
116Severe combined immunodeficiency (HP:0004430)2.08078831
117Hepatitis (HP:0012115)2.07625695
118Recurrent pneumonia (HP:0006532)2.07504360
119Obstructive lung disease (HP:0006536)2.07431615
120Chronic obstructive pulmonary disease (HP:0006510)2.07431615
121Progressive external ophthalmoplegia (HP:0000590)2.07349840
122Hematochezia (HP:0002573)2.07093047
123Conical tooth (HP:0000698)2.06824778
124Thyroiditis (HP:0100646)2.05331890
125Polyneuropathy (HP:0001271)2.04719122
126Prolonged neonatal jaundice (HP:0006579)2.04236793
127Vertigo (HP:0002321)2.03277711
128Skin ulcer (HP:0200042)1.99520504
129Neoplasm of the tracheobronchial system (HP:0100552)1.99106406
130Arthralgia (HP:0002829)1.98275946
131Microvesicular hepatic steatosis (HP:0001414)1.97980900
132Cortical dysplasia (HP:0002539)1.97966910
133Abnormality of cells of the lymphoid lineage (HP:0012140)1.93004356
134Lower limb hyperreflexia (HP:0002395)1.92677598
135Acrocyanosis (HP:0001063)1.92547758
136Cholecystitis (HP:0001082)1.90292002
137Abnormal gallbladder physiology (HP:0012438)1.90292002
138Spontaneous hematomas (HP:0007420)1.90264033
139Neutropenia (HP:0001875)1.90005602
140Abnormality of the endocardium (HP:0004306)1.89702755
141Chest pain (HP:0100749)1.89672643
142Palpebral edema (HP:0100540)1.89201926
143Ridged nail (HP:0001807)1.87694494
144Thrombophlebitis (HP:0004418)1.87570780
145Gingivitis (HP:0000230)1.85898934
146Recurrent lower respiratory tract infections (HP:0002783)1.85387582
147Acute hepatic failure (HP:0006554)1.85033085
148Long palpebral fissure (HP:0000637)1.79832054
149Combined immunodeficiency (HP:0005387)1.77319174
150Amaurosis fugax (HP:0100576)1.76174814
151Sparse scalp hair (HP:0002209)1.75717603
152Erythema (HP:0010783)1.75021983
153Progressive muscle weakness (HP:0003323)1.74861366
154Bronchiectasis (HP:0002110)1.70444714
155Abnormality of DNA repair (HP:0003254)1.69670685
156Carpal bone hypoplasia (HP:0001498)1.68862016

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.96456736
2IKBKB4.31943140
3TBK14.20545158
4TYK23.46873056
5SMG13.41171307
6BMPR23.29672022
7MAP3K133.17227015
8PRPF4B3.15331572
9IKBKE3.05407474
10JAK32.99946460
11BCR2.97601668
12CHUK2.87459340
13IRAK42.69840863
14MST42.67797938
15TESK12.60076569
16NME22.59765850
17VRK12.50869497
18BUB12.49137621
19TLK12.22074885
20JAK12.05834339
21VRK21.97234911
22EIF2AK31.93807383
23RIPK41.92570443
24NUAK11.87878345
25EEF2K1.76625540
26EPHB11.73062894
27DAPK31.72067622
28MAP3K101.71292985
29ERN11.60060154
30IRAK31.56267546
31DMPK1.51986792
32SCYL21.51856514
33ZAK1.51681407
34KDR1.50605066
35BCKDK1.50123621
36PIM21.50106829
37EIF2AK21.50020787
38LIMK11.41849732
39SYK1.35135575
40NEK11.32418212
41CDC71.31426455
42TAF11.31266235
43BMX1.30994134
44PTK61.27422178
45MAP4K11.27411721
46AURKA1.27275595
47TESK21.26899440
48MAPK111.26288244
49PASK1.24436621
50PKN11.18743703
51RPS6KB21.14097798
52ABL21.13812025
53BRAF1.12542020
54SIK31.09232364
55ERBB31.09227372
56MAPKAPK31.07311080
57TRIB31.06104463
58MAP2K61.05241463
59PRKCQ1.02879248
60CDK121.01948794
61STK100.99901741
62ARAF0.98578340
63SIK20.98561418
64FRK0.93699740
65MAP3K80.93310493
66PIM10.93129149
67ITK0.90172789
68LCK0.87931536
69RAF10.86896666
70JAK20.85722180
71FGFR30.79505131
72CCNB10.78348131
73MAPKAPK20.77675442
74TAOK20.77673838
75BTK0.75579396
76PTK2B0.75087043
77CSF1R0.73322690
78MAP3K90.72937046
79KIT0.72436131
80NEK60.71996699
81CHEK20.70462527
82PRKCE0.70291168
83CDK90.69566602
84PRKCD0.66899266
85CSK0.66764159
86BLK0.65855825
87STK240.65070112
88MELK0.60410917
89RPS6KA10.60105482
90HCK0.59975650
91YES10.59836023
92AURKB0.59347344
93WNK10.58626238
94INSRR0.55811235
95NME10.55782671
96FGFR40.53132613
97ILK0.52138928
98PDK10.50884728
99RET0.50588709
100ABL10.50336039
101CDK190.50225710
102MAPK120.49955154
103ATR0.49671458
104DAPK10.48604224
105MAPK70.48505396
106PRKCI0.47459491
107MARK30.45243433
108LYN0.44557083
109MAP3K20.43462940
110MAPKAPK50.43247409
111CDK70.43032130
112CHEK10.42753745
113ALK0.42611567
114MATK0.41641252
115TTN0.40505559
116FES0.39187693
117ICK0.39016833
118MOS0.38999087
119STK40.38670410
120PRKCH0.38208914
121CDK60.37958459
122AKT20.37740772
123EGFR0.37492813
124LRRK20.36780397
125RPS6KA50.36751728
126EPHA30.35523134
127KSR20.35198483
128TXK0.34768177
129CDK80.34474191
130GSK3A0.34445156
131PRKCZ0.33624561
132MAPK40.33539073
133TTK0.32505069
134TRPM70.32069138
135STK110.32040761
136PDPK10.31198668
137PAK10.31098209
138INSR0.28786657
139PAK30.25755463
140PBK0.25332137
141MAP2K70.25315878
142ROCK10.25263215
143FGR0.25211597
144MAP3K10.25028670
145STK30.24806651
146PIK3CA0.24287753
147CDK40.23875462
148SIK10.23259397
149ZAP700.22571462
150IRAK20.21249754
151DYRK1B0.19730274
152SRC0.19678954
153NTRK30.18951262
154IRAK10.18822783
155TAOK30.18640265
156PRKACG0.18612940
157RPS6KA60.17944217
158NEK90.17834388
159MAP3K120.17235808

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053306.53047557
2Graft-versus-host disease_Homo sapiens_hsa053325.41870834
3Autoimmune thyroid disease_Homo sapiens_hsa053204.52445727
4Type I diabetes mellitus_Homo sapiens_hsa049404.02870908
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.72955383
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.72994895
7Viral myocarditis_Homo sapiens_hsa054162.33460213
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31726223
9Alcoholism_Homo sapiens_hsa050342.15101022
10Leishmaniasis_Homo sapiens_hsa051402.13031770
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.12137596
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.10958319
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.10312445
14Measles_Homo sapiens_hsa051622.03307533
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88812089
16Rheumatoid arthritis_Homo sapiens_hsa053231.82672908
17TNF signaling pathway_Homo sapiens_hsa046681.75628429
18DNA replication_Homo sapiens_hsa030301.67950247
19African trypanosomiasis_Homo sapiens_hsa051431.66526059
20Toxoplasmosis_Homo sapiens_hsa051451.53986864
21Chemokine signaling pathway_Homo sapiens_hsa040621.50517022
22Pertussis_Homo sapiens_hsa051331.49608838
23Influenza A_Homo sapiens_hsa051641.44632524
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.43415361
25* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42383267
26Primary immunodeficiency_Homo sapiens_hsa053401.39757502
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35465390
28Herpes simplex infection_Homo sapiens_hsa051681.35364564
29Shigellosis_Homo sapiens_hsa051311.34888536
30Legionellosis_Homo sapiens_hsa051341.34246058
31Osteoclast differentiation_Homo sapiens_hsa043801.29934977
32Asthma_Homo sapiens_hsa053101.26833350
33Ribosome_Homo sapiens_hsa030101.26307531
34Malaria_Homo sapiens_hsa051441.21430334
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10502083
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07646446
37B cell receptor signaling pathway_Homo sapiens_hsa046621.07383464
38Antigen processing and presentation_Homo sapiens_hsa046121.04968738
39Apoptosis_Homo sapiens_hsa042101.01788589
40Mismatch repair_Homo sapiens_hsa034300.97971172
41Base excision repair_Homo sapiens_hsa034100.96810382
42Tuberculosis_Homo sapiens_hsa051520.96020816
43Hepatitis B_Homo sapiens_hsa051610.94671740
44T cell receptor signaling pathway_Homo sapiens_hsa046600.89195717
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86765278
46Salmonella infection_Homo sapiens_hsa051320.84582335
47Nucleotide excision repair_Homo sapiens_hsa034200.84371670
48Prolactin signaling pathway_Homo sapiens_hsa049170.81046264
49Pentose phosphate pathway_Homo sapiens_hsa000300.80874717
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80755836
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79613823
52Proteasome_Homo sapiens_hsa030500.78391504
53Spliceosome_Homo sapiens_hsa030400.78262406
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77004612
55Homologous recombination_Homo sapiens_hsa034400.73844683
56Biosynthesis of amino acids_Homo sapiens_hsa012300.72347223
57Fructose and mannose metabolism_Homo sapiens_hsa000510.69876615
58Amoebiasis_Homo sapiens_hsa051460.69420257
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69329884
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68159509
61Acute myeloid leukemia_Homo sapiens_hsa052210.65043508
62One carbon pool by folate_Homo sapiens_hsa006700.64784628
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63846186
64Hepatitis C_Homo sapiens_hsa051600.63811910
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63120234
66Pyrimidine metabolism_Homo sapiens_hsa002400.61646806
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60940075
68Epstein-Barr virus infection_Homo sapiens_hsa051690.56966490
69Cell cycle_Homo sapiens_hsa041100.56960480
70Staphylococcus aureus infection_Homo sapiens_hsa051500.54827274
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54394679
72Non-homologous end-joining_Homo sapiens_hsa034500.53787703
73Prion diseases_Homo sapiens_hsa050200.53162709
74Sulfur relay system_Homo sapiens_hsa041220.52663902
75Small cell lung cancer_Homo sapiens_hsa052220.52136699
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.49833396
77Type II diabetes mellitus_Homo sapiens_hsa049300.49757818
78Bladder cancer_Homo sapiens_hsa052190.48827029
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.45288578
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43397950
81Carbon metabolism_Homo sapiens_hsa012000.42435303
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.41898783
83Chronic myeloid leukemia_Homo sapiens_hsa052200.41248142
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.41204189
85p53 signaling pathway_Homo sapiens_hsa041150.40408155
86Viral carcinogenesis_Homo sapiens_hsa052030.40189166
87N-Glycan biosynthesis_Homo sapiens_hsa005100.39487287
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.38527167
89Phenylalanine metabolism_Homo sapiens_hsa003600.38322716
90Inositol phosphate metabolism_Homo sapiens_hsa005620.37225565
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34249961
92RNA transport_Homo sapiens_hsa030130.33849604
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32920701
94Phagosome_Homo sapiens_hsa041450.32301542
95Systemic lupus erythematosus_Homo sapiens_hsa053220.31681195
96Galactose metabolism_Homo sapiens_hsa000520.29301639
97Platelet activation_Homo sapiens_hsa046110.26869351
98RNA degradation_Homo sapiens_hsa030180.26291877
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25536135
100Arginine biosynthesis_Homo sapiens_hsa002200.24424492
101mRNA surveillance pathway_Homo sapiens_hsa030150.24198266
102HTLV-I infection_Homo sapiens_hsa051660.23573462
103Dorso-ventral axis formation_Homo sapiens_hsa043200.23131343
104Pancreatic cancer_Homo sapiens_hsa052120.22135325
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21794888
106RNA polymerase_Homo sapiens_hsa030200.20752226
107Hematopoietic cell lineage_Homo sapiens_hsa046400.20552022
108Tryptophan metabolism_Homo sapiens_hsa003800.19996607
109ErbB signaling pathway_Homo sapiens_hsa040120.19952102
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18550829
111VEGF signaling pathway_Homo sapiens_hsa043700.18347503
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17144280
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16924783
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16430109
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16250452
116MAPK signaling pathway_Homo sapiens_hsa040100.15955449
117MicroRNAs in cancer_Homo sapiens_hsa052060.15812625
118Proteoglycans in cancer_Homo sapiens_hsa052050.15765668
119Fanconi anemia pathway_Homo sapiens_hsa034600.15488881
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.11462110
121Morphine addiction_Homo sapiens_hsa050320.11351539
122Cholinergic synapse_Homo sapiens_hsa047250.09377181
123Glioma_Homo sapiens_hsa052140.08747484
124FoxO signaling pathway_Homo sapiens_hsa040680.07745820
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.07630936
126Ras signaling pathway_Homo sapiens_hsa040140.07195819
127Prostate cancer_Homo sapiens_hsa052150.05646006
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02185851
129Notch signaling pathway_Homo sapiens_hsa043300.02154198
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.01969827
131Non-small cell lung cancer_Homo sapiens_hsa052230.01817776
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.01510113
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01292923
134GABAergic synapse_Homo sapiens_hsa047270.00961005
135Endocytosis_Homo sapiens_hsa041440.00957027
136HIF-1 signaling pathway_Homo sapiens_hsa040660.00554529

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