

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 7.28551160 |
| 2 | regulation of interferon-beta biosynthetic process (GO:0045357) | 6.48769059 |
| 3 | B cell receptor signaling pathway (GO:0050853) | 6.15454428 |
| 4 | regulation of B cell receptor signaling pathway (GO:0050855) | 6.10909403 |
| 5 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 6.00129803 |
| 6 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 6.00129803 |
| 7 | modulation by symbiont of host immune response (GO:0052553) | 6.00129803 |
| 8 | positive regulation by symbiont of host defense response (GO:0052509) | 6.00129803 |
| 9 | modulation by symbiont of host defense response (GO:0052031) | 6.00129803 |
| 10 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 6.00129803 |
| 11 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.80702063 |
| 12 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.55694353 |
| 13 | immunoglobulin mediated immune response (GO:0016064) | 5.45581439 |
| 14 | positive regulation of interferon-alpha production (GO:0032727) | 5.44056276 |
| 15 | regulation of interferon-alpha production (GO:0032647) | 5.13679034 |
| 16 | neutrophil activation involved in immune response (GO:0002283) | 5.13655610 |
| 17 | macrophage activation involved in immune response (GO:0002281) | 4.93256322 |
| 18 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.83798982 |
| 19 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.83798982 |
| 20 | positive regulation of B cell differentiation (GO:0045579) | 4.81318505 |
| 21 | regulation of B cell differentiation (GO:0045577) | 4.54534729 |
| 22 | cytidine deamination (GO:0009972) | 4.43690915 |
| 23 | cytidine metabolic process (GO:0046087) | 4.43690915 |
| 24 | cytidine catabolic process (GO:0006216) | 4.43690915 |
| 25 | positive T cell selection (GO:0043368) | 4.36566662 |
| 26 | positive regulation of antigen processing and presentation (GO:0002579) | 4.28207172 |
| 27 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 4.23038928 |
| 28 | respiratory burst (GO:0045730) | 4.16013687 |
| 29 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 4.14880314 |
| 30 | B cell mediated immunity (GO:0019724) | 4.09055160 |
| 31 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.08872517 |
| 32 | detection of bacterium (GO:0016045) | 4.02620715 |
| 33 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 3.98370932 |
| 34 | myeloid cell activation involved in immune response (GO:0002275) | 3.93769439 |
| 35 | regulation of gamma-delta T cell activation (GO:0046643) | 3.93608609 |
| 36 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.92598455 |
| 37 | neutrophil activation (GO:0042119) | 3.88809425 |
| 38 | response to host immune response (GO:0052572) | 3.86991556 |
| 39 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.86991556 |
| 40 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.80580233 |
| 41 | natural killer cell mediated immunity (GO:0002228) | 3.78852326 |
| 42 | natural killer cell mediated cytotoxicity (GO:0042267) | 3.78852326 |
| 43 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.77972229 |
| 44 | detection of other organism (GO:0098543) | 3.77889024 |
| 45 | response to type I interferon (GO:0034340) | 3.76027393 |
| 46 | type I interferon signaling pathway (GO:0060337) | 3.74569891 |
| 47 | cellular response to type I interferon (GO:0071357) | 3.74569891 |
| 48 | cellular response to zinc ion (GO:0071294) | 3.74461845 |
| 49 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.73899887 |
| 50 | mast cell activation (GO:0045576) | 3.73879136 |
| 51 | response to peptidoglycan (GO:0032494) | 3.70207906 |
| 52 | negative regulation of cell killing (GO:0031342) | 3.66015341 |
| 53 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.66015341 |
| 54 | positive regulation of interferon-beta production (GO:0032728) | 3.65980949 |
| 55 | granulocyte activation (GO:0036230) | 3.65531456 |
| 56 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.63231188 |
| 57 | negative T cell selection (GO:0043383) | 3.61488558 |
| 58 | negative thymic T cell selection (GO:0045060) | 3.61194970 |
| 59 | microglial cell activation (GO:0001774) | 3.61034421 |
| 60 | T cell selection (GO:0045058) | 3.59448972 |
| 61 | regulation of antigen processing and presentation (GO:0002577) | 3.58308895 |
| 62 | mature B cell differentiation (GO:0002335) | 3.56827987 |
| 63 | positive regulation of mast cell activation (GO:0033005) | 3.55171158 |
| 64 | hydrogen peroxide biosynthetic process (GO:0050665) | 3.54670635 |
| 65 | response to host (GO:0075136) | 3.51924756 |
| 66 | response to host defenses (GO:0052200) | 3.51924756 |
| 67 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.51924756 |
| 68 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.49092838 |
| 69 | regulation of germinal center formation (GO:0002634) | 3.49020071 |
| 70 | macrophage activation (GO:0042116) | 3.48666994 |
| 71 | thymic T cell selection (GO:0045061) | 3.45257366 |
| 72 | T cell costimulation (GO:0031295) | 3.38538987 |
| 73 | defense response to protozoan (GO:0042832) | 3.36928380 |
| 74 | positive regulation of B cell proliferation (GO:0030890) | 3.35002826 |
| 75 | lymphocyte costimulation (GO:0031294) | 3.33810984 |
| 76 | activated T cell proliferation (GO:0050798) | 3.32995716 |
| 77 | leukocyte aggregation (GO:0070486) | 3.32467362 |
| 78 | B cell proliferation (GO:0042100) | 3.28424157 |
| 79 | germinal center formation (GO:0002467) | 3.27887019 |
| 80 | NIK/NF-kappaB signaling (GO:0038061) | 3.25941863 |
| 81 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.24373852 |
| 82 | positive regulation of mast cell degranulation (GO:0043306) | 3.24373852 |
| 83 | regulation of mast cell activation (GO:0033003) | 3.24224330 |
| 84 | myeloid dendritic cell activation (GO:0001773) | 3.20354744 |
| 85 | mature B cell differentiation involved in immune response (GO:0002313) | 3.20281238 |
| 86 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.20075481 |
| 87 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.17361559 |
| 88 | positive regulation of B cell activation (GO:0050871) | 3.16415456 |
| 89 | positive regulation of type 2 immune response (GO:0002830) | 3.15424083 |
| 90 | pinocytosis (GO:0006907) | 3.12883802 |
| 91 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.12073158 |
| 92 | myeloid leukocyte activation (GO:0002274) | 3.11065044 |
| 93 | regulation of interferon-gamma biosynthetic process (GO:0045072) | 3.11026905 |
| 94 | reactive oxygen species biosynthetic process (GO:1903409) | 3.10800803 |
| 95 | negative regulation of mast cell activation (GO:0033004) | 3.10166011 |
| 96 | regulation of mast cell degranulation (GO:0043304) | 3.09555674 |
| 97 | lymphocyte mediated immunity (GO:0002449) | 3.09473067 |
| 98 | mast cell activation involved in immune response (GO:0002279) | 3.09003467 |
| 99 | mast cell degranulation (GO:0043303) | 3.09003467 |
| 100 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.08615407 |
| 101 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.05448551 |
| 102 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.03818599 |
| 103 | regulation of T cell tolerance induction (GO:0002664) | 3.03287808 |
| 104 | myeloid dendritic cell differentiation (GO:0043011) | 2.99997177 |
| 105 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 2.98682483 |
| 106 | B cell homeostasis (GO:0001782) | 2.97442414 |
| 107 | regulation of B cell proliferation (GO:0030888) | 2.96962182 |
| 108 | negative regulation of B cell proliferation (GO:0030889) | 2.96223587 |
| 109 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.96192092 |
| 110 | positive thymic T cell selection (GO:0045059) | 2.96130093 |
| 111 | cellular response to interferon-beta (GO:0035458) | 2.96088022 |
| 112 | positive regulation of Rap GTPase activity (GO:0032854) | 2.95504278 |
| 113 | lymph node development (GO:0048535) | 2.94614760 |
| 114 | positive regulation of bone resorption (GO:0045780) | 2.94097710 |
| 115 | positive regulation of bone remodeling (GO:0046852) | 2.94097710 |
| 116 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 2.93855543 |
| 117 | actin nucleation (GO:0045010) | 2.92795253 |
| 118 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.92283170 |
| 119 | response to interferon-alpha (GO:0035455) | 2.91918047 |
| 120 | cellular response to interferon-gamma (GO:0071346) | 2.91782222 |
| 121 | response to protozoan (GO:0001562) | 2.91008170 |
| 122 | leukocyte mediated cytotoxicity (GO:0001909) | 2.90369805 |
| 123 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.89045165 |
| 124 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli | 2.88943055 |
| 125 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 2.88004104 |
| 126 | response to interferon-beta (GO:0035456) | 2.87211806 |
| 127 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.87107821 |
| 128 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.86311216 |
| 129 | positive regulation of interferon-gamma production (GO:0032729) | 2.86242994 |
| 130 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.86087351 |
| 131 | positive regulation of immunoglobulin production (GO:0002639) | 2.85217659 |
| 132 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 2.84985878 |
| 133 | T cell migration (GO:0072678) | 2.84975111 |
| 134 | adaptive immune response (GO:0002250) | 2.84460344 |
| 135 | mononuclear cell proliferation (GO:0032943) | 2.84061289 |
| 136 | lymphocyte proliferation (GO:0046651) | 2.83947607 |
| 137 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.82388461 |
| 138 | lymphocyte homeostasis (GO:0002260) | 2.81980305 |
| 139 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.80263532 |
| 140 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.80263532 |
| 141 | negative regulation of alpha-beta T cell activation (GO:0046636) | 2.80086022 |
| 142 | positive regulation of lymphocyte migration (GO:2000403) | 2.79396545 |
| 143 | positive regulation of calcium-mediated signaling (GO:0050850) | 2.77753678 |
| 144 | I-kappaB phosphorylation (GO:0007252) | 2.69850501 |
| 145 | detection of external biotic stimulus (GO:0098581) | 2.68757698 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 7.31876553 |
| 2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 5.88703372 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.57136756 |
| 4 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.36920229 |
| 5 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 4.07096504 |
| 6 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.95493130 |
| 7 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 3.94910067 |
| 8 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.58273118 |
| 9 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.47196142 |
| 10 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.10145648 |
| 11 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.02656424 |
| 12 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.97753079 |
| 13 | MYC_22102868_ChIP-Seq_BL_Human | 2.80863958 |
| 14 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.79082355 |
| 15 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.69060418 |
| 16 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.68320033 |
| 17 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.59431409 |
| 18 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.52093785 |
| 19 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.46481753 |
| 20 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.45458235 |
| 21 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.43708676 |
| 22 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.37903077 |
| 23 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.23622783 |
| 24 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.21713780 |
| 25 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.18341702 |
| 26 | MYB_26560356_Chip-Seq_TH2_Human | 2.17206361 |
| 27 | MAF_26560356_Chip-Seq_TH1_Human | 2.14183028 |
| 28 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.10330416 |
| 29 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.06359895 |
| 30 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.05997004 |
| 31 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.05498986 |
| 32 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 2.05119142 |
| 33 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.00054863 |
| 34 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.98400242 |
| 35 | * RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.96216131 |
| 36 | MYB_26560356_Chip-Seq_TH1_Human | 1.93749327 |
| 37 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.92331574 |
| 38 | SPI1_23127762_ChIP-Seq_K562_Human | 1.87988184 |
| 39 | UTX_26944678_Chip-Seq_JUKART_Human | 1.82308715 |
| 40 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.79110501 |
| 41 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.73381294 |
| 42 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.67224211 |
| 43 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.66701267 |
| 44 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.65388238 |
| 45 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.64544572 |
| 46 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.63770875 |
| 47 | GATA1_22025678_ChIP-Seq_K562_Human | 1.62989424 |
| 48 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.61858737 |
| 49 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.58560281 |
| 50 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.57471178 |
| 51 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.55497865 |
| 52 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.51374651 |
| 53 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.48217245 |
| 54 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.46029189 |
| 55 | P300_27268052_Chip-Seq_Bcells_Human | 1.45105938 |
| 56 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.42554582 |
| 57 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.38527959 |
| 58 | * MAF_26560356_Chip-Seq_TH2_Human | 1.36237423 |
| 59 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.33254986 |
| 60 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.32174450 |
| 61 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.30920092 |
| 62 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.29539432 |
| 63 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.26019784 |
| 64 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.23776554 |
| 65 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.22909285 |
| 66 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.22664203 |
| 67 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.21892549 |
| 68 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.21859885 |
| 69 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.21357775 |
| 70 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.20629783 |
| 71 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.19040396 |
| 72 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.18569281 |
| 73 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.16405895 |
| 74 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.16029919 |
| 75 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.15134295 |
| 76 | * SMRT_27268052_Chip-Seq_Bcells_Human | 1.14398463 |
| 77 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.14332899 |
| 78 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.14010096 |
| 79 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.11576790 |
| 80 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.11535918 |
| 81 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.11423150 |
| 82 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.10905461 |
| 83 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.09704526 |
| 84 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.07871524 |
| 85 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.07773025 |
| 86 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.07584866 |
| 87 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.07157586 |
| 88 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.06719976 |
| 89 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.06509294 |
| 90 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.06488943 |
| 91 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.06421291 |
| 92 | GATA3_26560356_Chip-Seq_TH2_Human | 1.05560514 |
| 93 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.05539097 |
| 94 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.05272016 |
| 95 | P68_20966046_ChIP-Seq_HELA_Human | 1.04479439 |
| 96 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.03747289 |
| 97 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.03121931 |
| 98 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.02942042 |
| 99 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.02234797 |
| 100 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.00553156 |
| 101 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.00057763 |
| 102 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.99779462 |
| 103 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.98096051 |
| 104 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.97953547 |
| 105 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.97019500 |
| 106 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.95272240 |
| 107 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.94541469 |
| 108 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.94359957 |
| 109 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.93170201 |
| 110 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.92959452 |
| 111 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.91642580 |
| 112 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.91292353 |
| 113 | * STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.90730125 |
| 114 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.90254839 |
| 115 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.88531287 |
| 116 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87520089 |
| 117 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.87179519 |
| 118 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.86793671 |
| 119 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.80614619 |
| 120 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.77602994 |
| 121 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.76954050 |
| 122 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.74642134 |
| 123 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.72501711 |
| 124 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.71845951 |
| 125 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.71757525 |
| 126 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.70018802 |
| 127 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.68654224 |
| 128 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.67319877 |
| 129 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.65967962 |
| 130 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.65634294 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 5.59681350 |
| 2 | MP0001790_abnormal_immune_system | 3.75808704 |
| 3 | MP0005387_immune_system_phenotype | 3.75808704 |
| 4 | * MP0001800_abnormal_humoral_immune | 3.68803436 |
| 5 | MP0003303_peritoneal_inflammation | 3.45433942 |
| 6 | MP0005000_abnormal_immune_tolerance | 3.38343156 |
| 7 | MP0000685_abnormal_immune_system | 3.33553590 |
| 8 | * MP0002452_abnormal_antigen_presenting | 3.30396684 |
| 9 | MP0003436_decreased_susceptibility_to | 3.27362306 |
| 10 | * MP0002723_abnormal_immune_serum | 2.92924473 |
| 11 | MP0009785_altered_susceptibility_to | 2.92514090 |
| 12 | MP0005671_abnormal_response_to | 2.87874027 |
| 13 | MP0002148_abnormal_hypersensitivity_rea | 2.86752071 |
| 14 | MP0002419_abnormal_innate_immunity | 2.83816470 |
| 15 | * MP0002420_abnormal_adaptive_immunity | 2.78373302 |
| 16 | * MP0001819_abnormal_immune_cell | 2.74324961 |
| 17 | MP0005025_abnormal_response_to | 2.71090391 |
| 18 | MP0005058_abnormal_lysosome_morphology | 2.68093180 |
| 19 | MP0006082_CNS_inflammation | 2.40790704 |
| 20 | * MP0002398_abnormal_bone_marrow | 2.32323508 |
| 21 | * MP0000716_abnormal_immune_system | 2.21050356 |
| 22 | * MP0000689_abnormal_spleen_morphology | 2.16697350 |
| 23 | MP0003787_abnormal_imprinting | 2.13466411 |
| 24 | MP0002166_altered_tumor_susceptibility | 2.05555947 |
| 25 | MP0002405_respiratory_system_inflammati | 1.99845940 |
| 26 | MP0003172_abnormal_lysosome_physiology | 1.98311223 |
| 27 | MP0004510_myositis | 1.97989103 |
| 28 | MP0001845_abnormal_inflammatory_respons | 1.87678637 |
| 29 | MP0005310_abnormal_salivary_gland | 1.86534649 |
| 30 | MP0003300_gastrointestinal_ulcer | 1.86361855 |
| 31 | MP0002722_abnormal_immune_system | 1.86121850 |
| 32 | MP0005464_abnormal_platelet_physiology | 1.83133500 |
| 33 | * MP0002429_abnormal_blood_cell | 1.82755781 |
| 34 | MP0003763_abnormal_thymus_physiology | 1.73392830 |
| 35 | MP0004947_skin_inflammation | 1.73005819 |
| 36 | MP0001853_heart_inflammation | 1.67430993 |
| 37 | MP0002396_abnormal_hematopoietic_system | 1.66527289 |
| 38 | MP0001533_abnormal_skeleton_physiology | 1.64393372 |
| 39 | MP0001873_stomach_inflammation | 1.59896506 |
| 40 | MP0010155_abnormal_intestine_physiology | 1.59421714 |
| 41 | MP0003183_abnormal_peptide_metabolism | 1.57870055 |
| 42 | MP0003191_abnormal_cellular_cholesterol | 1.56748933 |
| 43 | MP0002006_tumorigenesis | 1.55120797 |
| 44 | MP0000465_gastrointestinal_hemorrhage | 1.49870235 |
| 45 | MP0009278_abnormal_bone_marrow | 1.48457056 |
| 46 | MP0008469_abnormal_protein_level | 1.47984894 |
| 47 | MP0004808_abnormal_hematopoietic_stem | 1.45394449 |
| 48 | MP0002928_abnormal_bile_duct | 1.45362532 |
| 49 | MP0002933_joint_inflammation | 1.45179280 |
| 50 | MP0003724_increased_susceptibility_to | 1.44964795 |
| 51 | MP0001986_abnormal_taste_sensitivity | 1.44889536 |
| 52 | MP0005075_abnormal_melanosome_morpholog | 1.35708568 |
| 53 | MP0005174_abnormal_tail_pigmentation | 1.33605262 |
| 54 | MP0001545_abnormal_hematopoietic_system | 1.32630911 |
| 55 | MP0005397_hematopoietic_system_phenotyp | 1.32630911 |
| 56 | MP0009333_abnormal_splenocyte_physiolog | 1.31056381 |
| 57 | MP0000703_abnormal_thymus_morphology | 1.29932016 |
| 58 | MP0009840_abnormal_foam_cell | 1.25910029 |
| 59 | MP0003448_altered_tumor_morphology | 1.25731457 |
| 60 | MP0008877_abnormal_DNA_methylation | 1.22886129 |
| 61 | MP0002653_abnormal_ependyma_morphology | 1.22179901 |
| 62 | MP0010307_abnormal_tumor_latency | 1.16931475 |
| 63 | MP0000015_abnormal_ear_pigmentation | 1.11276357 |
| 64 | MP0000604_amyloidosis | 1.11252977 |
| 65 | MP0000343_altered_response_to | 1.07402821 |
| 66 | MP0002132_abnormal_respiratory_system | 1.06081109 |
| 67 | MP0000858_altered_metastatic_potential | 1.03715431 |
| 68 | MP0000490_abnormal_crypts_of | 1.02822679 |
| 69 | MP0002998_abnormal_bone_remodeling | 1.01949052 |
| 70 | MP0002693_abnormal_pancreas_physiology | 1.01581630 |
| 71 | MP0009764_decreased_sensitivity_to | 1.00628021 |
| 72 | MP0002277_abnormal_respiratory_mucosa | 0.99065766 |
| 73 | MP0002163_abnormal_gland_morphology | 0.98654460 |
| 74 | MP0003866_abnormal_defecation | 0.98298119 |
| 75 | MP0005645_abnormal_hypothalamus_physiol | 0.97921764 |
| 76 | MP0000569_abnormal_digit_pigmentation | 0.95452533 |
| 77 | MP0004142_abnormal_muscle_tone | 0.92568061 |
| 78 | MP0005166_decreased_susceptibility_to | 0.91605467 |
| 79 | MP0003690_abnormal_glial_cell | 0.90235514 |
| 80 | MP0002019_abnormal_tumor_incidence | 0.89750228 |
| 81 | MP0008004_abnormal_stomach_pH | 0.85081714 |
| 82 | MP0009379_abnormal_foot_pigmentation | 0.83821646 |
| 83 | MP0002139_abnormal_hepatobiliary_system | 0.81297560 |
| 84 | MP0003656_abnormal_erythrocyte_physiolo | 0.81274464 |
| 85 | MP0004381_abnormal_hair_follicle | 0.79272355 |
| 86 | MP0009763_increased_sensitivity_to | 0.77660891 |
| 87 | MP0002136_abnormal_kidney_physiology | 0.77068141 |
| 88 | MP0002095_abnormal_skin_pigmentation | 0.75205870 |
| 89 | MP0003828_pulmonary_edema | 0.74828333 |
| 90 | MP0003566_abnormal_cell_adhesion | 0.74571581 |
| 91 | MP0002638_abnormal_pupillary_reflex | 0.74041887 |
| 92 | MP0002876_abnormal_thyroid_physiology | 0.73915489 |
| 93 | MP0001905_abnormal_dopamine_level | 0.73453796 |
| 94 | MP0003075_altered_response_to | 0.72518437 |
| 95 | MP0001663_abnormal_digestive_system | 0.72037091 |
| 96 | MP0003195_calcinosis | 0.71763117 |
| 97 | MP0001764_abnormal_homeostasis | 0.71476086 |
| 98 | MP0001879_abnormal_lymphatic_vessel | 0.71068628 |
| 99 | MP0002822_catalepsy | 0.70989989 |
| 100 | MP0003693_abnormal_embryo_hatching | 0.70725895 |
| 101 | MP0005381_digestive/alimentary_phenotyp | 0.68489223 |
| 102 | MP0005084_abnormal_gallbladder_morpholo | 0.67802220 |
| 103 | MP0005379_endocrine/exocrine_gland_phen | 0.66447930 |
| 104 | MP0000249_abnormal_blood_vessel | 0.66384284 |
| 105 | MP0001958_emphysema | 0.64675085 |
| 106 | MP0001851_eye_inflammation | 0.64262391 |
| 107 | MP0005390_skeleton_phenotype | 0.63630261 |
| 108 | MP0005076_abnormal_cell_differentiation | 0.60555251 |
| 109 | MP0004019_abnormal_vitamin_homeostasis | 0.58975196 |
| 110 | MP0004742_abnormal_vestibular_system | 0.58212423 |
| 111 | MP0003795_abnormal_bone_structure | 0.57988194 |
| 112 | MP0003091_abnormal_cell_migration | 0.57652747 |
| 113 | MP0005257_abnormal_intraocular_pressure | 0.55964126 |
| 114 | MP0006036_abnormal_mitochondrial_physio | 0.55686525 |
| 115 | MP0000313_abnormal_cell_death | 0.55658382 |
| 116 | MP0002138_abnormal_hepatobiliary_system | 0.55589219 |
| 117 | MP0003878_abnormal_ear_physiology | 0.54797630 |
| 118 | MP0005377_hearing/vestibular/ear_phenot | 0.54797630 |
| 119 | MP0010329_abnormal_lipoprotein_level | 0.54741669 |
| 120 | MP0001944_abnormal_pancreas_morphology | 0.53155290 |
| 121 | MP0002909_abnormal_adrenal_gland | 0.52151465 |
| 122 | MP0009642_abnormal_blood_homeostasis | 0.52009960 |
| 123 | MP0006054_spinal_hemorrhage | 0.50938365 |
| 124 | MP0004883_abnormal_blood_vessel | 0.50177825 |
| 125 | MP0010094_abnormal_chromosome_stability | 0.49848387 |
| 126 | MP0006292_abnormal_olfactory_placode | 0.49602280 |
| 127 | MP0003252_abnormal_bile_duct | 0.49243565 |
| 128 | MP0009643_abnormal_urine_homeostasis | 0.48237242 |
| 129 | MP0009765_abnormal_xenobiotic_induced | 0.48206315 |
| 130 | MP0005023_abnormal_wound_healing | 0.47364119 |
| 131 | MP0003077_abnormal_cell_cycle | 0.47186350 |
| 132 | MP0005164_abnormal_response_to | 0.45821467 |
| 133 | MP0008057_abnormal_DNA_replication | 0.45800025 |
| 134 | MP0002135_abnormal_kidney_morphology | 0.45434103 |
| 135 | MP0000598_abnormal_liver_morphology | 0.44834378 |
| 136 | MP0008873_increased_physiological_sensi | 0.43186124 |
| 137 | MP0005083_abnormal_biliary_tract | 0.42727808 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 6.10278494 |
| 2 | Agammaglobulinemia (HP:0004432) | 5.81045251 |
| 3 | Recurrent bacterial skin infections (HP:0005406) | 5.45581725 |
| 4 | Cellulitis (HP:0100658) | 5.13743746 |
| 5 | Eczematoid dermatitis (HP:0000976) | 4.94166192 |
| 6 | Recurrent bronchitis (HP:0002837) | 4.67254261 |
| 7 | Gastrointestinal stroma tumor (HP:0100723) | 4.64482867 |
| 8 | Recurrent viral infections (HP:0004429) | 4.52854191 |
| 9 | Colitis (HP:0002583) | 4.23227870 |
| 10 | Meningitis (HP:0001287) | 4.06202881 |
| 11 | Chronic otitis media (HP:0000389) | 4.03309330 |
| 12 | Vacuolated lymphocytes (HP:0001922) | 4.01168658 |
| 13 | IgM deficiency (HP:0002850) | 3.94665441 |
| 14 | Abnormality of macrophages (HP:0004311) | 3.89267145 |
| 15 | Mediastinal lymphadenopathy (HP:0100721) | 3.82359141 |
| 16 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.80370588 |
| 17 | Inflammation of the large intestine (HP:0002037) | 3.79106095 |
| 18 | Recurrent sinusitis (HP:0011108) | 3.79051466 |
| 19 | Recurrent fungal infections (HP:0002841) | 3.78655392 |
| 20 | Increased cerebral lipofuscin (HP:0011813) | 3.77637709 |
| 21 | Recurrent skin infections (HP:0001581) | 3.71420513 |
| 22 | Verrucae (HP:0200043) | 3.68400461 |
| 23 | Papilloma (HP:0012740) | 3.68400461 |
| 24 | Osteomyelitis (HP:0002754) | 3.67533974 |
| 25 | Recurrent pneumonia (HP:0006532) | 3.67333486 |
| 26 | Gastrointestinal inflammation (HP:0004386) | 3.65704598 |
| 27 | Vasculitis (HP:0002633) | 3.64021067 |
| 28 | Chronic sinusitis (HP:0011109) | 3.63518418 |
| 29 | Chronic obstructive pulmonary disease (HP:0006510) | 3.62342727 |
| 30 | Obstructive lung disease (HP:0006536) | 3.62342727 |
| 31 | Systemic lupus erythematosus (HP:0002725) | 3.50641993 |
| 32 | Myositis (HP:0100614) | 3.46468917 |
| 33 | Recurrent lower respiratory tract infections (HP:0002783) | 3.39742883 |
| 34 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.34370548 |
| 35 | Disinhibition (HP:0000734) | 3.30471725 |
| 36 | Lymphopenia (HP:0001888) | 3.27544660 |
| 37 | Panhypogammaglobulinemia (HP:0003139) | 3.24587282 |
| 38 | Emphysema (HP:0002097) | 3.24246285 |
| 39 | Pustule (HP:0200039) | 3.24157896 |
| 40 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.16669841 |
| 41 | Dysostosis multiplex (HP:0000943) | 3.16312649 |
| 42 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.14593436 |
| 43 | Recurrent cutaneous fungal infections (HP:0011370) | 3.11096462 |
| 44 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.11096462 |
| 45 | Autoimmune thrombocytopenia (HP:0001973) | 3.07989185 |
| 46 | Thyroiditis (HP:0100646) | 3.02831639 |
| 47 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.90227856 |
| 48 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.90227856 |
| 49 | Abnormality of glycolipid metabolism (HP:0010969) | 2.90227856 |
| 50 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.87787696 |
| 51 | Sepsis (HP:0100806) | 2.86041789 |
| 52 | Increased IgM level (HP:0003496) | 2.84001761 |
| 53 | Gingivitis (HP:0000230) | 2.81207484 |
| 54 | Recurrent otitis media (HP:0000403) | 2.74340725 |
| 55 | Basal ganglia calcification (HP:0002135) | 2.72291705 |
| 56 | B lymphocytopenia (HP:0010976) | 2.71205746 |
| 57 | Abnormality of B cell number (HP:0010975) | 2.71205746 |
| 58 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.68162153 |
| 59 | Hypoplasia of the thymus (HP:0000778) | 2.65925868 |
| 60 | Skin rash (HP:0000988) | 2.63693738 |
| 61 | Agnosia (HP:0010524) | 2.63096328 |
| 62 | Interstitial pulmonary disease (HP:0006530) | 2.62880898 |
| 63 | Restrictive lung disease (HP:0002091) | 2.62083243 |
| 64 | Bronchitis (HP:0012387) | 2.58269965 |
| 65 | IgG deficiency (HP:0004315) | 2.56950251 |
| 66 | Abnormality of the prostate (HP:0008775) | 2.56264433 |
| 67 | Abnormality of T cells (HP:0002843) | 2.51813185 |
| 68 | Thrombocytosis (HP:0001894) | 2.49678622 |
| 69 | Severe combined immunodeficiency (HP:0004430) | 2.49056149 |
| 70 | Gastrointestinal infarctions (HP:0005244) | 2.48485200 |
| 71 | Papilledema (HP:0001085) | 2.47698834 |
| 72 | Neutropenia (HP:0001875) | 2.46895145 |
| 73 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.46160101 |
| 74 | Mucopolysacchariduria (HP:0008155) | 2.46160101 |
| 75 | Orchitis (HP:0100796) | 2.45785506 |
| 76 | Glomerulonephritis (HP:0000099) | 2.43291785 |
| 77 | Stomatitis (HP:0010280) | 2.43142530 |
| 78 | Pulmonary infiltrates (HP:0002113) | 2.42784637 |
| 79 | Nasal polyposis (HP:0100582) | 2.40921847 |
| 80 | Abnormality of T cell physiology (HP:0011840) | 2.38469656 |
| 81 | T lymphocytopenia (HP:0005403) | 2.38396194 |
| 82 | Hematochezia (HP:0002573) | 2.37677419 |
| 83 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.37658997 |
| 84 | Loss of speech (HP:0002371) | 2.36971517 |
| 85 | Small epiphyses (HP:0010585) | 2.36916873 |
| 86 | Abnormality of T cell number (HP:0011839) | 2.35958641 |
| 87 | Petechiae (HP:0000967) | 2.35176886 |
| 88 | Retrobulbar optic neuritis (HP:0100654) | 2.34168809 |
| 89 | Optic neuritis (HP:0100653) | 2.34168809 |
| 90 | IgA deficiency (HP:0002720) | 2.33411575 |
| 91 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.29025339 |
| 92 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.29025339 |
| 93 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.29025339 |
| 94 | Spontaneous hematomas (HP:0007420) | 2.23169656 |
| 95 | Myocardial infarction (HP:0001658) | 2.22554616 |
| 96 | Axonal loss (HP:0003447) | 2.18860539 |
| 97 | Prostate neoplasm (HP:0100787) | 2.18319312 |
| 98 | Lymphoma (HP:0002665) | 2.17574208 |
| 99 | Granulocytopenia (HP:0001913) | 2.17049681 |
| 100 | Mitral stenosis (HP:0001718) | 2.16252777 |
| 101 | Skin ulcer (HP:0200042) | 2.16090516 |
| 102 | Leukopenia (HP:0001882) | 2.14266250 |
| 103 | Abnormality of the nasal mucosa (HP:0000433) | 2.14191416 |
| 104 | Encephalitis (HP:0002383) | 2.13670402 |
| 105 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.13195129 |
| 106 | Increased IgE level (HP:0003212) | 2.12047871 |
| 107 | Urticaria (HP:0001025) | 2.11915532 |
| 108 | Pulmonary fibrosis (HP:0002206) | 2.08631156 |
| 109 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.08122901 |
| 110 | Periodontitis (HP:0000704) | 2.06237090 |
| 111 | Leukocytosis (HP:0001974) | 2.05838050 |
| 112 | Combined immunodeficiency (HP:0005387) | 2.05375223 |
| 113 | Hemoptysis (HP:0002105) | 2.05278855 |
| 114 | Eosinophilia (HP:0001880) | 2.05079036 |
| 115 | Hepatosplenomegaly (HP:0001433) | 2.02159219 |
| 116 | Abnormality of eosinophils (HP:0001879) | 1.99175031 |
| 117 | Severe visual impairment (HP:0001141) | 1.93255128 |
| 118 | Abnormality of the peritoneum (HP:0002585) | 1.87973519 |
| 119 | Abnormality of the pleura (HP:0002103) | 1.87191995 |
| 120 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.85677001 |
| 121 | Hypergammaglobulinemia (HP:0010702) | 1.85141894 |
| 122 | Chest pain (HP:0100749) | 1.84106937 |
| 123 | Albinism (HP:0001022) | 1.83611025 |
| 124 | Malnutrition (HP:0004395) | 1.79603352 |
| 125 | Hypertensive crisis (HP:0100735) | 1.76556617 |
| 126 | Hypoproteinemia (HP:0003075) | 1.70337938 |
| 127 | Prolonged bleeding time (HP:0003010) | 1.69620111 |
| 128 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.69185401 |
| 129 | Progressive neurologic deterioration (HP:0002344) | 1.67962042 |
| 130 | Agitation (HP:0000713) | 1.67761318 |
| 131 | Asplenia (HP:0001746) | 1.66466865 |
| 132 | Chronic diarrhea (HP:0002028) | 1.65545819 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 5.28182021 |
| 2 | KIT | 3.69522318 |
| 3 | BLK | 3.46717329 |
| 4 | TBK1 | 2.91129853 |
| 5 | TYK2 | 2.87735042 |
| 6 | ERN1 | 2.84752535 |
| 7 | RIPK4 | 2.80320254 |
| 8 | IRAK4 | 2.80163162 |
| 9 | CSF1R | 2.74908283 |
| 10 | MAP3K10 | 2.64483823 |
| 11 | SYK | 2.63348641 |
| 12 | GRK6 | 2.33153388 |
| 13 | MAP3K14 | 2.28781734 |
| 14 | IKBKE | 2.13577727 |
| 15 | FES | 2.10585168 |
| 16 | BTK | 2.04458391 |
| 17 | JAK1 | 1.98990607 |
| 18 | IRAK3 | 1.91828125 |
| 19 | LYN | 1.88611206 |
| 20 | NME2 | 1.88414424 |
| 21 | ZAP70 | 1.72165681 |
| 22 | CSK | 1.65707342 |
| 23 | HCK | 1.65516783 |
| 24 | IKBKB | 1.57823475 |
| 25 | STK10 | 1.57381640 |
| 26 | JAK3 | 1.56940736 |
| 27 | TGFBR2 | 1.49105437 |
| 28 | TLK1 | 1.45722055 |
| 29 | LCK | 1.43391128 |
| 30 | TEC | 1.43312894 |
| 31 | MAP3K13 | 1.40659307 |
| 32 | LRRK2 | 1.38713847 |
| 33 | MAP2K3 | 1.28267855 |
| 34 | SIK2 | 1.17101171 |
| 35 | TXK | 1.16515262 |
| 36 | MAPK12 | 1.15151343 |
| 37 | PIM1 | 1.13688477 |
| 38 | CDK19 | 1.12172220 |
| 39 | MATK | 1.08928292 |
| 40 | PIK3CG | 1.05864214 |
| 41 | ITK | 1.05020378 |
| 42 | PIM2 | 0.97184621 |
| 43 | STK4 | 0.97058001 |
| 44 | FRK | 0.95765366 |
| 45 | TAOK1 | 0.94891375 |
| 46 | DYRK1B | 0.94394329 |
| 47 | MST4 | 0.91133936 |
| 48 | NEK9 | 0.90384035 |
| 49 | FGFR4 | 0.89326608 |
| 50 | ADRBK2 | 0.89088292 |
| 51 | FGFR3 | 0.87896959 |
| 52 | FGR | 0.87826513 |
| 53 | PRPF4B | 0.87276122 |
| 54 | SIK3 | 0.87025982 |
| 55 | PASK | 0.86009933 |
| 56 | SCYL2 | 0.84316740 |
| 57 | MARK2 | 0.83691906 |
| 58 | MARK3 | 0.81731549 |
| 59 | RPS6KA4 | 0.81710812 |
| 60 | TAOK3 | 0.79972969 |
| 61 | EIF2AK1 | 0.78016752 |
| 62 | CHUK | 0.77868025 |
| 63 | TESK2 | 0.77257716 |
| 64 | CDC42BPA | 0.77189407 |
| 65 | PRKCQ | 0.75321830 |
| 66 | ARAF | 0.74837146 |
| 67 | PRKD2 | 0.74633394 |
| 68 | PKN1 | 0.74560472 |
| 69 | MAPK13 | 0.74511579 |
| 70 | PKN2 | 0.72954912 |
| 71 | CDK4 | 0.69757722 |
| 72 | TNK2 | 0.68894339 |
| 73 | STK11 | 0.68429478 |
| 74 | CLK1 | 0.68327907 |
| 75 | MAP3K1 | 0.68323140 |
| 76 | BCKDK | 0.64204597 |
| 77 | PBK | 0.63861858 |
| 78 | STK16 | 0.63342263 |
| 79 | PRKCD | 0.62718945 |
| 80 | ABL1 | 0.62441340 |
| 81 | NTRK2 | 0.62241028 |
| 82 | JAK2 | 0.60499759 |
| 83 | ACVR1B | 0.59424547 |
| 84 | RPS6KA6 | 0.58473250 |
| 85 | DMPK | 0.58205492 |
| 86 | TAOK2 | 0.57783767 |
| 87 | EGFR | 0.56729267 |
| 88 | RPS6KL1 | 0.56248656 |
| 89 | RPS6KC1 | 0.56248656 |
| 90 | MAP3K3 | 0.53527847 |
| 91 | FYN | 0.52829298 |
| 92 | PINK1 | 0.52584117 |
| 93 | EIF2AK3 | 0.51238282 |
| 94 | PRKCZ | 0.51122588 |
| 95 | NEK2 | 0.50131072 |
| 96 | CDK9 | 0.47571200 |
| 97 | MAPK7 | 0.47137239 |
| 98 | TRIB3 | 0.45981048 |
| 99 | MAPK4 | 0.44968508 |
| 100 | TGFBR1 | 0.42062105 |
| 101 | MAP3K11 | 0.40885411 |
| 102 | MAPK15 | 0.39005768 |
| 103 | TTN | 0.38603250 |
| 104 | MAP2K6 | 0.38572880 |
| 105 | GRK7 | 0.38396446 |
| 106 | NUAK1 | 0.37730644 |
| 107 | PRKCI | 0.37611419 |
| 108 | ATR | 0.36774552 |
| 109 | RPS6KA5 | 0.36019478 |
| 110 | GRK1 | 0.35138794 |
| 111 | BMPR2 | 0.34471719 |
| 112 | MAP3K8 | 0.34220020 |
| 113 | NLK | 0.33572577 |
| 114 | HIPK2 | 0.32678051 |
| 115 | DAPK3 | 0.32615855 |
| 116 | DYRK2 | 0.32050367 |
| 117 | PRKD1 | 0.30143637 |
| 118 | MAP2K2 | 0.28686051 |
| 119 | MAPK11 | 0.28260647 |
| 120 | MAP3K5 | 0.27940696 |
| 121 | MAPKAPK2 | 0.27553049 |
| 122 | NTRK3 | 0.27241210 |
| 123 | FLT3 | 0.27221937 |
| 124 | INSR | 0.27193334 |
| 125 | YES1 | 0.25847020 |
| 126 | PRKCH | 0.25116549 |
| 127 | PDK1 | 0.24563167 |
| 128 | EIF2AK2 | 0.24205289 |
| 129 | KDR | 0.24154300 |
| 130 | CDK12 | 0.23844315 |
| 131 | ALK | 0.23835716 |
| 132 | STK24 | 0.22741872 |
| 133 | EPHB1 | 0.22376720 |
| 134 | MELK | 0.21654943 |
| 135 | CDK6 | 0.18871236 |
| 136 | TRPM7 | 0.17701061 |
| 137 | CAMK1D | 0.17651778 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.91780083 |
| 2 | * B cell receptor signaling pathway_Homo sapiens_hsa04662 | 3.83237695 |
| 3 | Leishmaniasis_Homo sapiens_hsa05140 | 2.95700413 |
| 4 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.83317920 |
| 5 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.72666531 |
| 6 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.66279900 |
| 7 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.55957877 |
| 8 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.39092935 |
| 9 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.24935527 |
| 10 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.21124794 |
| 11 | Lysosome_Homo sapiens_hsa04142 | 2.15769935 |
| 12 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 2.10675709 |
| 13 | Measles_Homo sapiens_hsa05162 | 2.08025721 |
| 14 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.07695134 |
| 15 | Other glycan degradation_Homo sapiens_hsa00511 | 2.06037312 |
| 16 | Tuberculosis_Homo sapiens_hsa05152 | 2.03784026 |
| 17 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.02894941 |
| 18 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.85460606 |
| 19 | Pertussis_Homo sapiens_hsa05133 | 1.82715701 |
| 20 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.79862048 |
| 21 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.67973237 |
| 22 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.63072462 |
| 23 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.60517412 |
| 24 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.59603597 |
| 25 | Influenza A_Homo sapiens_hsa05164 | 1.57065642 |
| 26 | Legionellosis_Homo sapiens_hsa05134 | 1.48155714 |
| 27 | Apoptosis_Homo sapiens_hsa04210 | 1.45204625 |
| 28 | Shigellosis_Homo sapiens_hsa05131 | 1.40985988 |
| 29 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.40280972 |
| 30 | Malaria_Homo sapiens_hsa05144 | 1.35407693 |
| 31 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.35009340 |
| 32 | Phagosome_Homo sapiens_hsa04145 | 1.33403152 |
| 33 | DNA replication_Homo sapiens_hsa03030 | 1.32085053 |
| 34 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.30529508 |
| 35 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.26159725 |
| 36 | Salmonella infection_Homo sapiens_hsa05132 | 1.25605587 |
| 37 | Hepatitis B_Homo sapiens_hsa05161 | 1.24540636 |
| 38 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.24262365 |
| 39 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.23831632 |
| 40 | Base excision repair_Homo sapiens_hsa03410 | 1.20705363 |
| 41 | Mismatch repair_Homo sapiens_hsa03430 | 1.18858000 |
| 42 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.18295303 |
| 43 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.13778448 |
| 44 | Allograft rejection_Homo sapiens_hsa05330 | 1.13014458 |
| 45 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.08286142 |
| 46 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.05928110 |
| 47 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.01821355 |
| 48 | Asthma_Homo sapiens_hsa05310 | 0.97534451 |
| 49 | Ribosome_Homo sapiens_hsa03010 | 0.95767973 |
| 50 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.95200100 |
| 51 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.94857080 |
| 52 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.92511960 |
| 53 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.92484744 |
| 54 | Hepatitis C_Homo sapiens_hsa05160 | 0.91246547 |
| 55 | Platelet activation_Homo sapiens_hsa04611 | 0.91124912 |
| 56 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.88950185 |
| 57 | Viral myocarditis_Homo sapiens_hsa05416 | 0.88697493 |
| 58 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.84075989 |
| 59 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.81289649 |
| 60 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.80950557 |
| 61 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.80152223 |
| 62 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.77056115 |
| 63 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.76444257 |
| 64 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.75169838 |
| 65 | Homologous recombination_Homo sapiens_hsa03440 | 0.75146835 |
| 66 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.73426252 |
| 67 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.72929727 |
| 68 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.68798724 |
| 69 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.67607826 |
| 70 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.67339714 |
| 71 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.66760800 |
| 72 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.62697945 |
| 73 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.56337066 |
| 74 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.56053308 |
| 75 | Endocytosis_Homo sapiens_hsa04144 | 0.54937067 |
| 76 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.53557016 |
| 77 | HTLV-I infection_Homo sapiens_hsa05166 | 0.52896676 |
| 78 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.50259578 |
| 79 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.48421337 |
| 80 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.47989643 |
| 81 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.44104376 |
| 82 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.42423006 |
| 83 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.41642980 |
| 84 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.41285996 |
| 85 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.40750226 |
| 86 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.40679531 |
| 87 | Proteasome_Homo sapiens_hsa03050 | 0.38302886 |
| 88 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.36914509 |
| 89 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.35591302 |
| 90 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.35366513 |
| 91 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.34438945 |
| 92 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.34198504 |
| 93 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.33148924 |
| 94 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.31938809 |
| 95 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.31740424 |
| 96 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.31513736 |
| 97 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.31230478 |
| 98 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.30971238 |
| 99 | Parkinsons disease_Homo sapiens_hsa05012 | 0.30815993 |
| 100 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.28358272 |
| 101 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.27301186 |
| 102 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.24419383 |
| 103 | Phototransduction_Homo sapiens_hsa04744 | 0.24384637 |
| 104 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.24336219 |
| 105 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.24206092 |
| 106 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.23931051 |
| 107 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.23377095 |
| 108 | Colorectal cancer_Homo sapiens_hsa05210 | 0.22332635 |
| 109 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.21475520 |
| 110 | Glioma_Homo sapiens_hsa05214 | 0.20810297 |
| 111 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.20089902 |
| 112 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.19665299 |
| 113 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.18694415 |
| 114 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.18526333 |
| 115 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.18431841 |
| 116 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.18217564 |
| 117 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.18201846 |
| 118 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.17565412 |
| 119 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.15870195 |
| 120 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.14901782 |
| 121 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.14575060 |
| 122 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.13003222 |
| 123 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.12765158 |
| 124 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.11214169 |
| 125 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.10227179 |
| 126 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.08872580 |
| 127 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.05902490 |
| 128 | Alzheimers disease_Homo sapiens_hsa05010 | 0.04267082 |
| 129 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.03565960 |

