CD79A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* B cell receptor signaling pathway (GO:0050853)8.81646694
2antigen processing and presentation of endogenous antigen (GO:0019883)7.04033929
3positive regulation of gamma-delta T cell activation (GO:0046645)6.98771143
4positive regulation of B cell differentiation (GO:0045579)6.53672639
5regulation of B cell differentiation (GO:0045577)6.20214819
6regulation of B cell receptor signaling pathway (GO:0050855)5.96211690
7regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.48972399
8regulation of gamma-delta T cell differentiation (GO:0045586)5.33115580
9cellular response to zinc ion (GO:0071294)5.32014523
10negative regulation of cell killing (GO:0031342)5.01561582
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.01561582
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.00917715
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.00917715
14positive regulation by symbiont of host defense response (GO:0052509)4.96808079
15modulation by symbiont of host defense response (GO:0052031)4.96808079
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.96808079
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.96808079
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.96808079
19modulation by symbiont of host immune response (GO:0052553)4.96808079
20B cell mediated immunity (GO:0019724)4.87376405
21regulation of gamma-delta T cell activation (GO:0046643)4.86819324
22detection of bacterium (GO:0016045)4.81080603
23negative regulation of histone methylation (GO:0031061)4.60250471
24regulation of antigen processing and presentation (GO:0002577)4.57864196
25regulation of dendritic cell antigen processing and presentation (GO:0002604)4.55361805
26detection of other organism (GO:0098543)4.47780476
27mature B cell differentiation (GO:0002335)4.40006218
28cytidine metabolic process (GO:0046087)4.37567973
29cytidine catabolic process (GO:0006216)4.37567973
30cytidine deamination (GO:0009972)4.37567973
31regulation of B cell proliferation (GO:0030888)4.37308367
32negative regulation of B cell proliferation (GO:0030889)4.32342966
33type I interferon signaling pathway (GO:0060337)4.28990969
34cellular response to type I interferon (GO:0071357)4.28990969
35positive thymic T cell selection (GO:0045059)4.28158000
36regulation of histone H3-K9 methylation (GO:0051570)4.27685746
37response to type I interferon (GO:0034340)4.26238658
38serine transport (GO:0032329)4.19297951
39regulation of superoxide anion generation (GO:0032928)4.11443187
40negative regulation of phagocytosis (GO:0050765)4.05472649
41CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.04380276
42regulation of B cell apoptotic process (GO:0002902)4.02432959
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.02151255
44regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.01308948
45* antigen receptor-mediated signaling pathway (GO:0050851)3.93817901
46regulation of interferon-beta biosynthetic process (GO:0045357)3.91809323
47L-serine transport (GO:0015825)3.85565760
48regulation of interferon-gamma biosynthetic process (GO:0045072)3.83742190
49B cell homeostasis (GO:0001782)3.83065447
50positive regulation of interferon-alpha production (GO:0032727)3.82024832
51lymphocyte homeostasis (GO:0002260)3.79718645
52T cell migration (GO:0072678)3.75164507
53* B cell proliferation (GO:0042100)3.71640052
54positive regulation of Rap GTPase activity (GO:0032854)3.70563999
55positive regulation of histone deacetylation (GO:0031065)3.68841762
56T cell homeostasis (GO:0043029)3.67140862
57positive regulation of antigen processing and presentation (GO:0002579)3.67085599
58V(D)J recombination (GO:0033151)3.65269654
59* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.63945854
60regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.61929475
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.60818046
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.58499265
63lymphocyte costimulation (GO:0031294)3.58104055
64positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.57810291
65regulation of interferon-alpha production (GO:0032647)3.55807230
66natural killer cell differentiation (GO:0001779)3.55505402
67positive regulation of immunoglobulin production (GO:0002639)3.53570157
68defense response to protozoan (GO:0042832)3.52172414
69Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.51906686
70immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.51906686
71Fc-gamma receptor signaling pathway (GO:0038094)3.51906686
72* B cell activation (GO:0042113)3.51022925
73positive regulation of gene expression, epigenetic (GO:0045815)3.48591835
74positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.48557526
75negative regulation of bone resorption (GO:0045779)3.48000378
76regulation of interleukin-12 biosynthetic process (GO:0045075)3.46158363
77Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.45760622
78positive regulation of B cell activation (GO:0050871)3.44467539
79response to interleukin-15 (GO:0070672)3.43902712
80positive regulation of B cell proliferation (GO:0030890)3.43565424
81lymph node development (GO:0048535)3.41573321
82negative regulation of B cell apoptotic process (GO:0002903)3.40604710
83T-helper 1 type immune response (GO:0042088)3.39671930
84immunoglobulin mediated immune response (GO:0016064)3.36657393
85response to host immune response (GO:0052572)3.36583248
86response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.36583248
87positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.35143398
88regulation of B cell activation (GO:0050864)3.35061361
89cellular response to interleukin-15 (GO:0071350)3.33200297
90mature B cell differentiation involved in immune response (GO:0002313)3.32679371
91positive regulation of type 2 immune response (GO:0002830)3.32579940
92negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.31867787
93cellular response to interferon-gamma (GO:0071346)3.31202000
94leukocyte homeostasis (GO:0001776)3.30122069
95T cell selection (GO:0045058)3.26749055
96leukocyte aggregation (GO:0070486)3.24175529
97negative regulation of lymphocyte mediated immunity (GO:0002707)3.23838557
98vesicle targeting (GO:0006903)3.23185240
99regulation of germinal center formation (GO:0002634)3.22857771
100germinal center formation (GO:0002467)3.18261540
101pyrimidine ribonucleoside catabolic process (GO:0046133)3.17629876
102detection of external biotic stimulus (GO:0098581)3.17231328
103positive regulation of humoral immune response (GO:0002922)3.15580958
104regulation of alpha-beta T cell proliferation (GO:0046640)3.13424695
105thymic T cell selection (GO:0045061)3.12812706
106adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.11894323
107respiratory burst (GO:0045730)3.11887702
108tachykinin receptor signaling pathway (GO:0007217)3.11201069
109response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11033414
110response to host (GO:0075136)3.11033414
111response to host defenses (GO:0052200)3.11033414
112neutrophil activation (GO:0042119)3.09826804
113production of molecular mediator involved in inflammatory response (GO:0002532)3.08278743
114myeloid dendritic cell activation (GO:0001773)3.07329592
115Peyers patch development (GO:0048541)3.05237346
116mucosal-associated lymphoid tissue development (GO:0048537)3.05237346
117negative thymic T cell selection (GO:0045060)3.03956012
118T cell lineage commitment (GO:0002360)3.03681094
119regulation of Rap GTPase activity (GO:0032317)3.02135356
120positive regulation of macrophage cytokine production (GO:0060907)2.99252330
121somatic hypermutation of immunoglobulin genes (GO:0016446)2.98949659
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98949659
123response to protozoan (GO:0001562)2.98505817
124positive regulation of cell adhesion mediated by integrin (GO:0033630)2.98476999
125positive regulation of protein deacetylation (GO:0090312)2.97523768
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96777382
127negative regulation of gene silencing (GO:0060969)2.95391384
128positive regulation of granulocyte differentiation (GO:0030854)2.95246909
129myeloid dendritic cell differentiation (GO:0043011)2.95141365
130viral transcription (GO:0019083)2.95010538
131positive regulation of T cell mediated cytotoxicity (GO:0001916)2.94624350
132regulation of T-helper 1 cell differentiation (GO:0045625)2.92875782
133regulation of T cell mediated cytotoxicity (GO:0001914)2.92684899
134macrophage activation involved in immune response (GO:0002281)2.92437558
135ribosomal small subunit assembly (GO:0000028)2.90720916
136chaperone mediated protein folding requiring cofactor (GO:0051085)2.90356666
137negative regulation of leukocyte mediated immunity (GO:0002704)2.88882500
138tolerance induction (GO:0002507)2.88735673
139positive regulation of interleukin-2 production (GO:0032743)2.87769256
140hepatocyte apoptotic process (GO:0097284)2.87612781
141humoral immune response (GO:0006959)2.86941341
142positive T cell selection (GO:0043368)2.86631880
143* B cell differentiation (GO:0030183)2.86472438
144NIK/NF-kappaB signaling (GO:0038061)2.86056616
145complement activation, classical pathway (GO:0006958)2.85990583
146positive regulation of lamellipodium assembly (GO:0010592)2.85036782
147interferon-gamma-mediated signaling pathway (GO:0060333)2.82353803
148activation of JUN kinase activity (GO:0007257)2.76098104
149T cell costimulation (GO:0031295)2.75998384
150adaptation of signaling pathway (GO:0023058)2.74458270
151negative T cell selection (GO:0043383)2.73962501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.92775901
2E2F7_22180533_ChIP-Seq_HELA_Human5.74214343
3MYC_22102868_ChIP-Seq_BL_Human5.43282380
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.14510637
5* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.96059070
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.77812335
7* VDR_21846776_ChIP-Seq_THP-1_Human3.54156597
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.23895548
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.23081874
10E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.09407076
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.07800012
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01078244
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.86610833
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.86246430
15RUNX_20019798_ChIP-Seq_JUKART_Human2.52437161
16* MAF_26560356_Chip-Seq_TH1_Human2.47592187
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.46637778
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.46319935
19CIITA_25753668_ChIP-Seq_RAJI_Human2.39875036
20* MYB_26560356_Chip-Seq_TH1_Human2.39613941
21* MYB_26560356_Chip-Seq_TH2_Human2.39345103
22* UTX_26944678_Chip-Seq_JUKART_Human2.38818370
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27336527
24* VDR_24763502_ChIP-Seq_THP-1_Human2.24563052
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16474781
26SCL_19346495_ChIP-Seq_HPC-7_Human2.15913756
27TCF7_22412390_ChIP-Seq_EML_Mouse2.14376025
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.06617275
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98217808
30SPI1_23547873_ChIP-Seq_NB4_Human1.96389236
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92740844
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91057690
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83569591
34* KDM2B_26808549_Chip-Seq_DND41_Human1.80718344
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74786778
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70764713
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66917668
38MAF_26560356_Chip-Seq_TH2_Human1.66635223
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66513776
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.65749102
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65467147
42SPI1_23127762_ChIP-Seq_K562_Human1.63746975
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62105969
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61506667
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60959254
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58777073
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55159252
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50784728
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.48211733
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47291898
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45728470
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45701199
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42626135
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41750181
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41585321
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40929572
57GATA3_27048872_Chip-Seq_THYMUS_Human1.38195960
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37280232
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36516962
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35768610
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.34443117
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25643368
63FOXP3_21729870_ChIP-Seq_TREG_Human1.24896789
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24842938
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21299293
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20355132
67GATA1_22025678_ChIP-Seq_K562_Human1.19986683
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18043423
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15331950
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13124126
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.11145898
72KDM5A_27292631_Chip-Seq_BREAST_Human1.08898067
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08125642
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08083404
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06551004
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.05180216
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02111814
78VDR_23849224_ChIP-Seq_CD4+_Human1.01846354
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01551122
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01203871
81E2F1_21310950_ChIP-Seq_MCF-7_Human0.99996207
82NCOR1_26117541_ChIP-Seq_K562_Human0.99175150
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97892469
84KDM2B_26808549_Chip-Seq_JURKAT_Human0.95280826
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94410325
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94219210
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93290495
88P300_27268052_Chip-Seq_Bcells_Human0.92471326
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91641592
90PU_27001747_Chip-Seq_BMDM_Mouse0.90936086
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89183412
92XRN2_22483619_ChIP-Seq_HELA_Human0.87759478
93SPI1_20517297_ChIP-Seq_HL60_Human0.85663165
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85423966
95TP63_19390658_ChIP-ChIP_HaCaT_Human0.85185177
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.85120253
97MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84937891
98P68_20966046_ChIP-Seq_HELA_Human0.84930914
99* LXR_22292898_ChIP-Seq_THP-1_Human0.84880089
100GATA3_26560356_Chip-Seq_TH2_Human0.84537355
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84528948
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84017031
103* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81896087
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80242618
105CTCF_26484167_Chip-Seq_Bcells_Mouse0.80121710
106BCL6_27268052_Chip-Seq_Bcells_Human0.79771747
107RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78865872
108CTCF_21964334_ChIP-Seq_BJAB-B_Human0.78146938
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77562071
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76015090
111RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73918418
112CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73085507
113SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72861534
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71628159
115BCOR_27268052_Chip-Seq_Bcells_Human0.71270430
116SMRT_27268052_Chip-Seq_Bcells_Human0.71019448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.38656797
2* MP0001800_abnormal_humoral_immune5.06766383
3* MP0005387_immune_system_phenotype4.60096614
4* MP0001790_abnormal_immune_system4.60096614
5MP0000685_abnormal_immune_system3.94237839
6* MP0002452_abnormal_antigen_presenting3.79440972
7MP0003303_peritoneal_inflammation3.57058135
8MP0005000_abnormal_immune_tolerance3.15183236
9* MP0002723_abnormal_immune_serum3.11909962
10* MP0002398_abnormal_bone_marrow3.11755898
11* MP0002420_abnormal_adaptive_immunity3.09876365
12* MP0001819_abnormal_immune_cell3.00234921
13MP0005671_abnormal_response_to2.93711171
14* MP0000716_abnormal_immune_system2.79541043
15* MP0000689_abnormal_spleen_morphology2.78883820
16MP0002722_abnormal_immune_system2.42056515
17MP0003763_abnormal_thymus_physiology2.31408817
18* MP0002429_abnormal_blood_cell2.30683428
19MP0002396_abnormal_hematopoietic_system2.26396154
20MP0003300_gastrointestinal_ulcer2.11338329
21MP0005025_abnormal_response_to2.02571524
22MP0004808_abnormal_hematopoietic_stem2.01580945
23MP0003724_increased_susceptibility_to1.99537749
24MP0002166_altered_tumor_susceptibility1.94410823
25MP0009785_altered_susceptibility_to1.92027287
26MP0000703_abnormal_thymus_morphology1.88729301
27MP0003436_decreased_susceptibility_to1.87440132
28MP0001873_stomach_inflammation1.80057526
29MP0002419_abnormal_innate_immunity1.75872474
30MP0002148_abnormal_hypersensitivity_rea1.71272368
31MP0002405_respiratory_system_inflammati1.70516510
32MP0008057_abnormal_DNA_replication1.69161854
33MP0010155_abnormal_intestine_physiology1.67818289
34MP0006054_spinal_hemorrhage1.62929168
35MP0001845_abnormal_inflammatory_respons1.61156148
36MP0010094_abnormal_chromosome_stability1.60688232
37MP0004947_skin_inflammation1.60339707
38MP0005645_abnormal_hypothalamus_physiol1.50948807
39MP0001879_abnormal_lymphatic_vessel1.45401393
40MP0002019_abnormal_tumor_incidence1.39394198
41MP0001853_heart_inflammation1.38686027
42MP0004510_myositis1.37651108
43MP0002933_joint_inflammation1.36189432
44MP0003866_abnormal_defecation1.34343554
45MP0009278_abnormal_bone_marrow1.33306937
46MP0005464_abnormal_platelet_physiology1.32501811
47MP0009333_abnormal_splenocyte_physiolog1.30761280
48MP0001348_abnormal_lacrimal_gland1.28350342
49MP0010234_abnormal_vibrissa_follicle1.24672079
50MP0002006_tumorigenesis1.23007359
51MP0005310_abnormal_salivary_gland1.22817749
52* MP0003077_abnormal_cell_cycle1.13851871
53MP0000465_gastrointestinal_hemorrhage1.13198138
54MP0010352_gastrointestinal_tract_polyps1.11326334
55MP0003183_abnormal_peptide_metabolism1.11160559
56MP0003693_abnormal_embryo_hatching1.09133367
57MP0000490_abnormal_crypts_of1.05197739
58MP0003172_abnormal_lysosome_physiology1.03873976
59MP0005075_abnormal_melanosome_morpholog1.03057467
60MP0003111_abnormal_nucleus_morphology1.01295700
61MP0002009_preneoplasia0.99202062
62MP0008961_abnormal_basal_metabolism0.97470422
63MP0002136_abnormal_kidney_physiology0.95804939
64MP0005076_abnormal_cell_differentiation0.94643265
65MP0008260_abnormal_autophagy0.91593017
66MP0004381_abnormal_hair_follicle0.90047706
67MP0005397_hematopoietic_system_phenotyp0.88673924
68MP0001545_abnormal_hematopoietic_system0.88673924
69MP0000350_abnormal_cell_proliferation0.88241961
70MP0002132_abnormal_respiratory_system0.85957232
71MP0003091_abnormal_cell_migration0.85392769
72MP0004957_abnormal_blastocyst_morpholog0.85136561
73MP0008469_abnormal_protein_level0.80339719
74MP0000858_altered_metastatic_potential0.77490463
75MP0003045_fibrosis0.76579515
76MP0003787_abnormal_imprinting0.74550012
77MP0008874_decreased_physiological_sensi0.73695363
78MP0002928_abnormal_bile_duct0.73068110
79MP0003252_abnormal_bile_duct0.72090272
80MP0002095_abnormal_skin_pigmentation0.71474558
81MP0001730_embryonic_growth_arrest0.70264862
82MP0002138_abnormal_hepatobiliary_system0.70031730
83MP0000313_abnormal_cell_death0.69436790
84MP0003566_abnormal_cell_adhesion0.65567643
85MP0010307_abnormal_tumor_latency0.64971132
86MP0009764_decreased_sensitivity_to0.64889510
87MP0002139_abnormal_hepatobiliary_system0.64870909
88MP0005174_abnormal_tail_pigmentation0.64359693
89MP0001663_abnormal_digestive_system0.62798920
90MP0008058_abnormal_DNA_repair0.62458681
91MP0009763_increased_sensitivity_to0.59864255
92MP0001533_abnormal_skeleton_physiology0.58777757
93MP0002909_abnormal_adrenal_gland0.58285533
94MP0001851_eye_inflammation0.56279357
95MP0002083_premature_death0.54893022
96MP0003646_muscle_fatigue0.53562618
97* MP0005621_abnormal_cell_physiology0.52731201
98MP0000013_abnormal_adipose_tissue0.52692073
99MP0005381_digestive/alimentary_phenotyp0.51692070
100MP0009931_abnormal_skin_appearance0.50386869
101MP0000477_abnormal_intestine_morphology0.49292083
102MP0000249_abnormal_blood_vessel0.49218118
103MP0002998_abnormal_bone_remodeling0.48997581
104MP0000609_abnormal_liver_physiology0.48639021
105MP0002693_abnormal_pancreas_physiology0.48169763
106MP0000003_abnormal_adipose_tissue0.46950702
107MP0004883_abnormal_blood_vessel0.46886698
108MP0003943_abnormal_hepatobiliary_system0.46493797
109MP0003191_abnormal_cellular_cholesterol0.45923146
110MP0005166_decreased_susceptibility_to0.45722552
111MP0006082_CNS_inflammation0.45512388
112MP0001784_abnormal_fluid_regulation0.45507475
113MP0003453_abnormal_keratinocyte_physiol0.43463427
114MP0005451_abnormal_body_composition0.42820796
115MP0000767_abnormal_smooth_muscle0.41879762
116MP0000015_abnormal_ear_pigmentation0.41830395
117MP0000598_abnormal_liver_morphology0.40657483
118MP0002163_abnormal_gland_morphology0.40144645
119MP0002080_prenatal_lethality0.39629334
120MP0001986_abnormal_taste_sensitivity0.39046911
121MP0000371_diluted_coat_color0.38503008
122MP0009642_abnormal_blood_homeostasis0.36734107
123MP0003075_altered_response_to0.35972187
124MP0009643_abnormal_urine_homeostasis0.35741410
125MP0009765_abnormal_xenobiotic_induced0.34774850
126MP0002254_reproductive_system_inflammat0.33523544

Predicted human phenotypes

RankGene SetZ-score
1* Agammaglobulinemia (HP:0004432)9.63826869
2Gastrointestinal stroma tumor (HP:0100723)7.02447540
3* Cellulitis (HP:0100658)6.80796117
4Recurrent sinusitis (HP:0011108)6.30740151
5* Papilloma (HP:0012740)6.14596972
6* Verrucae (HP:0200043)6.14596972
7Colitis (HP:0002583)6.06736753
8B lymphocytopenia (HP:0010976)5.33084452
9Abnormality of B cell number (HP:0010975)5.33084452
10Recurrent viral infections (HP:0004429)5.25057023
11IgM deficiency (HP:0002850)5.20364816
12Panhypogammaglobulinemia (HP:0003139)5.17501899
13Chronic sinusitis (HP:0011109)5.17496274
14Inflammation of the large intestine (HP:0002037)5.15669341
15Gastrointestinal inflammation (HP:0004386)5.08327939
16Small epiphyses (HP:0010585)4.95096795
17* Recurrent bronchitis (HP:0002837)4.92307170
18* Meningitis (HP:0001287)4.64970801
19Recurrent pneumonia (HP:0006532)4.63503561
20Lymphopenia (HP:0001888)4.60158491
21Thyroiditis (HP:0100646)4.46468834
22Abnormality of cells of the lymphoid lineage (HP:0012140)4.43238621
23Recurrent lower respiratory tract infections (HP:0002783)4.36757880
24Emphysema (HP:0002097)4.26475787
25Abnormal delayed hypersensitivity skin test (HP:0002963)4.20138250
26* Osteomyelitis (HP:0002754)3.85689702
27Abnormality of macrophages (HP:0004311)3.82803317
28Chronic otitis media (HP:0000389)3.82777643
29Recurrent gram-negative bacterial infections (HP:0005420)3.58509351
30Vertebral arch anomaly (HP:0008438)3.56729766
31Mitral stenosis (HP:0001718)3.55580912
32Vasculitis (HP:0002633)3.55055135
33IgA deficiency (HP:0002720)3.49327840
34* Sepsis (HP:0100806)3.48125168
35* Recurrent otitis media (HP:0000403)3.39609204
36Restrictive lung disease (HP:0002091)3.35835910
37Urticaria (HP:0001025)3.32052581
38Recurrent fungal infections (HP:0002841)3.31263296
39IgG deficiency (HP:0004315)3.27392409
40Hypoplasia of the capital femoral epiphysis (HP:0003090)3.24987123
41Flattened epiphyses (HP:0003071)3.19749031
42Abnormality of the fingertips (HP:0001211)2.92469520
43Abnormality of T cells (HP:0002843)2.89638972
44Abnormality of the prostate (HP:0008775)2.88259302
45Chronic mucocutaneous candidiasis (HP:0002728)2.83520517
46Recurrent cutaneous fungal infections (HP:0011370)2.83520517
47Abnormality of T cell physiology (HP:0011840)2.82472756
48T lymphocytopenia (HP:0005403)2.81248824
49Abnormality of the intervertebral disk (HP:0005108)2.80319417
50Recurrent abscess formation (HP:0002722)2.80131317
51Autoimmune thrombocytopenia (HP:0001973)2.79801371
52Recurrent bacterial skin infections (HP:0005406)2.78669257
53Abnormality of T cell number (HP:0011839)2.75139673
54Lymphoma (HP:0002665)2.74362205
55* Bronchitis (HP:0012387)2.69682805
56Increased IgM level (HP:0003496)2.66232941
57Combined immunodeficiency (HP:0005387)2.65452392
58Gastrointestinal infarctions (HP:0005244)2.64430596
59Ulnar bowing (HP:0003031)2.62379202
60Irregular vertebral endplates (HP:0003301)2.61604140
61Viral hepatitis (HP:0006562)2.59988120
62Absent epiphyses (HP:0010577)2.58737818
63Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.58737818
64Chest pain (HP:0100749)2.58215158
65Retrobulbar optic neuritis (HP:0100654)2.53030771
66Optic neuritis (HP:0100653)2.53030771
67Leukopenia (HP:0001882)2.52182512
68Severe combined immunodeficiency (HP:0004430)2.50334656
69Mediastinal lymphadenopathy (HP:0100721)2.49580669
70Myositis (HP:0100614)2.49390985
71Elevated erythrocyte sedimentation rate (HP:0003565)2.46570065
72* Skin rash (HP:0000988)2.42798603
73Orchitis (HP:0100796)2.40064269
74Recurrent skin infections (HP:0001581)2.39924877
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.39886979
76Abnormality of the pleura (HP:0002103)2.32677937
77Arthropathy (HP:0003040)2.32430638
78Hypertensive crisis (HP:0100735)2.29810698
79Thrombocytosis (HP:0001894)2.28048623
80Interstitial pulmonary disease (HP:0006530)2.25259659
81Hypoplasia of the thymus (HP:0000778)2.23534233
82Gingivitis (HP:0000230)2.23331648
83Hypergammaglobulinemia (HP:0010702)2.17134983
84Premature loss of primary teeth (HP:0006323)2.11057187
85* Skin ulcer (HP:0200042)2.08774945
86Abnormality of the peritoneum (HP:0002585)2.07306974
87Encephalitis (HP:0002383)2.05617151
88Hemoptysis (HP:0002105)2.04589321
89Spontaneous hematomas (HP:0007420)2.03106466
90Eosinophilia (HP:0001880)2.02792680
91Basal cell carcinoma (HP:0002671)2.01415264
92Xerostomia (HP:0000217)1.99946808
93Increased IgE level (HP:0003212)1.99323064
94Nasal polyposis (HP:0100582)1.98281193
95Abnormality of male internal genitalia (HP:0000022)1.98154348
96Pustule (HP:0200039)1.97456085
97Pulmonary fibrosis (HP:0002206)1.95142036
98Abnormality of the vertebral endplates (HP:0005106)1.93897582
99Chronic diarrhea (HP:0002028)1.93713487
100Obstructive lung disease (HP:0006536)1.93422721
101Chronic obstructive pulmonary disease (HP:0006510)1.93422721
102Limited elbow extension (HP:0001377)1.92666149
103Prolonged bleeding time (HP:0003010)1.91930646
104Fatigue (HP:0012378)1.91222162
105Autoimmune hemolytic anemia (HP:0001890)1.90256895
106Petechiae (HP:0000967)1.90172193
107Keratoconjunctivitis sicca (HP:0001097)1.89983893
108Stomatitis (HP:0010280)1.89231830
109Barrel-shaped chest (HP:0001552)1.87808086
110Acrocyanosis (HP:0001063)1.86832035
111Epistaxis (HP:0000421)1.82966442
112Hypochromic anemia (HP:0001931)1.82824391
113* Neutropenia (HP:0001875)1.81179205
114Leukocytosis (HP:0001974)1.79839586
115Pulmonary embolism (HP:0002204)1.79237606
116Granulocytopenia (HP:0001913)1.78094734
117Vertebral clefting (HP:0008428)1.77559380
118Eczematoid dermatitis (HP:0000976)1.75841962
119Hematochezia (HP:0002573)1.73137702
120Arthralgia (HP:0002829)1.71652959
121Aplasia/Hypoplasia of the thymus (HP:0010515)1.69047880
122Aortic regurgitation (HP:0001659)1.66803840
123Long eyelashes (HP:0000527)1.63639910
124Abnormality of eosinophils (HP:0001879)1.63165673
125Abnormality of the nasal mucosa (HP:0000433)1.63114935
126Papilledema (HP:0001085)1.61401398
127Cutaneous melanoma (HP:0012056)1.57945233
128Pulmonary infiltrates (HP:0002113)1.52284169
129Hepatitis (HP:0012115)1.51783179
130Abnormality of small intestinal villus morphology (HP:0011472)1.51062761
131Villous atrophy (HP:0011473)1.51062761
132Abnormality of the thymus (HP:0000777)1.50541426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.37031963
2MAP3K105.98006410
3ERN14.11833595
4GRK63.59110698
5EEF2K2.98113248
6PRPF4B2.89894571
7CSF1R2.81825038
8BLK2.76086339
9BTK2.51946995
10STK102.35099058
11SIK22.31733894
12RIPK42.30429246
13* SYK2.26366286
14LRRK22.17039404
15SMG12.12003567
16MAP3K131.73341162
17CDK121.63555135
18TYK21.51876169
19CLK11.38979443
20MAP3K141.37662105
21* LYN1.37026099
22NEK21.32240461
23BMPR21.29371856
24HCK1.28093928
25JAK11.27271589
26FES1.24592006
27EIF2AK31.23745730
28MST41.22291131
29VRK11.17002291
30TRIB31.16853610
31MARK31.13112092
32CDK41.09624095
33SIK31.09321810
34NEK91.09286222
35TBK11.05688672
36PIM11.03608581
37PRKCH1.03242384
38CSK1.01353672
39ITK1.00425821
40CDK190.99453483
41TNK20.97278631
42SIK10.94449368
43LCK0.91658981
44MAPK120.90737588
45IKBKB0.89996982
46PKN20.88364278
47ARAF0.87731212
48KIT0.87442967
49BRD40.87426698
50PRKD20.86763711
51MAP3K110.86458897
52ZAP700.85996122
53STK40.85732870
54PRKCQ0.85132668
55TEC0.84482369
56GRK10.82224042
57HIPK20.79560784
58IRAK30.76209108
59JAK30.75988043
60RPS6KB20.74941275
61JAK20.71918945
62RPS6KA40.70065466
63TESK20.69280454
64ALK0.68404570
65MAPK110.66638256
66DAPK30.66109502
67FGFR30.64856173
68IKBKE0.63341160
69MAP3K70.62583417
70TXK0.62042408
71MAPK40.61346642
72MAPK70.61304288
73MAP3K10.61116655
74KDR0.60505461
75MELK0.59775292
76TGFBR20.59237867
77DYRK1B0.58252880
78PRKD10.57239527
79IRAK40.56869487
80CDC42BPA0.56533429
81RPS6KA50.56256977
82NME20.56242797
83CHUK0.56176227
84CDK90.56165478
85ZAK0.55741997
86KSR20.55741316
87MATK0.54443619
88NLK0.51641173
89FRK0.49900548
90ABL10.49691857
91PDK10.49665424
92TAOK20.49601586
93MAP3K90.48593424
94TAOK10.48338429
95MAP3K80.47006632
96BRAF0.44466097
97PDPK10.44434666
98CDC70.44377522
99MAP2K20.44224527
100TAOK30.42728726
101SCYL20.42482140
102TLK10.39206484
103MARK20.38649068
104WNK10.36481745
105* FYN0.35594478
106CHEK10.34835607
107PASK0.34136034
108DYRK30.33689374
109ICK0.33650141
110TAF10.33236832
111STK240.33228498
112PTK60.33215613
113FGFR40.33120423
114FGFR20.33023620
115PRKCI0.31534464
116YES10.30686542
117FGR0.30569577
118CSNK1D0.29837760
119CDK60.29606427
120CCNB10.29442087
121MAP2K30.28545899
122MAPKAPK20.28146512
123ATR0.26004017
124SGK30.25261553
125MAP2K10.24847246
126EGFR0.23731607
127IRAK20.23591200
128PRKCD0.21266898
129MAPK30.21133074

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053406.42706728
2* B cell receptor signaling pathway_Homo sapiens_hsa046626.04787112
3Allograft rejection_Homo sapiens_hsa053304.59181751
4Autoimmune thyroid disease_Homo sapiens_hsa053204.32386588
5Asthma_Homo sapiens_hsa053104.18739649
6Graft-versus-host disease_Homo sapiens_hsa053324.11579161
7Type I diabetes mellitus_Homo sapiens_hsa049403.51350999
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.83513743
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.78016528
10Staphylococcus aureus infection_Homo sapiens_hsa051502.61113229
11Hematopoietic cell lineage_Homo sapiens_hsa046402.52406866
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.41015271
13Base excision repair_Homo sapiens_hsa034102.33275678
14Non-homologous end-joining_Homo sapiens_hsa034502.22768419
15Osteoclast differentiation_Homo sapiens_hsa043802.09267160
16Antigen processing and presentation_Homo sapiens_hsa046122.04143313
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.98797177
18Mismatch repair_Homo sapiens_hsa034301.85421985
19DNA replication_Homo sapiens_hsa030301.79618332
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.69762048
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69673740
22Leishmaniasis_Homo sapiens_hsa051401.58728790
23T cell receptor signaling pathway_Homo sapiens_hsa046601.57647356
24Non-small cell lung cancer_Homo sapiens_hsa052231.53328630
25Herpes simplex infection_Homo sapiens_hsa051681.40405852
26Epstein-Barr virus infection_Homo sapiens_hsa051691.39967881
27Ribosome_Homo sapiens_hsa030101.39594711
28Measles_Homo sapiens_hsa051621.38730152
29Chemokine signaling pathway_Homo sapiens_hsa040621.32828837
30Chronic myeloid leukemia_Homo sapiens_hsa052201.30916216
31Alcoholism_Homo sapiens_hsa050341.30476418
32Rheumatoid arthritis_Homo sapiens_hsa053231.29429018
33Tuberculosis_Homo sapiens_hsa051521.22980503
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.21041478
35Shigellosis_Homo sapiens_hsa051311.13706403
36Acute myeloid leukemia_Homo sapiens_hsa052211.13686577
37Platelet activation_Homo sapiens_hsa046111.12666363
38Hepatitis B_Homo sapiens_hsa051611.12597163
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12171811
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.06878109
41Pancreatic cancer_Homo sapiens_hsa052121.06449656
42Spliceosome_Homo sapiens_hsa030401.05311157
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99854981
44Viral carcinogenesis_Homo sapiens_hsa052030.99714319
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99212839
46Apoptosis_Homo sapiens_hsa042100.98753902
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96426268
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.94414104
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93589683
50HTLV-I infection_Homo sapiens_hsa051660.93090075
51Homologous recombination_Homo sapiens_hsa034400.92527362
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91943303
53Toxoplasmosis_Homo sapiens_hsa051450.91473218
54Phagosome_Homo sapiens_hsa041450.90725548
55Influenza A_Homo sapiens_hsa051640.89473097
56Glioma_Homo sapiens_hsa052140.83985624
57VEGF signaling pathway_Homo sapiens_hsa043700.77288363
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74426662
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73609362
60Viral myocarditis_Homo sapiens_hsa054160.72852539
61mTOR signaling pathway_Homo sapiens_hsa041500.70760962
62Cell cycle_Homo sapiens_hsa041100.70187023
63Small cell lung cancer_Homo sapiens_hsa052220.69095847
64FoxO signaling pathway_Homo sapiens_hsa040680.68820313
65MicroRNAs in cancer_Homo sapiens_hsa052060.68774495
66Nucleotide excision repair_Homo sapiens_hsa034200.68569519
67Inositol phosphate metabolism_Homo sapiens_hsa005620.67995543
68p53 signaling pathway_Homo sapiens_hsa041150.67934682
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67013650
70African trypanosomiasis_Homo sapiens_hsa051430.62917885
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62601247
72mRNA surveillance pathway_Homo sapiens_hsa030150.62404929
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61633049
74Colorectal cancer_Homo sapiens_hsa052100.59711616
75Lysine degradation_Homo sapiens_hsa003100.59088401
76Insulin resistance_Homo sapiens_hsa049310.59031655
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57568574
78MAPK signaling pathway_Homo sapiens_hsa040100.57058994
79Prostate cancer_Homo sapiens_hsa052150.53558688
80TNF signaling pathway_Homo sapiens_hsa046680.53337440
81Hepatitis C_Homo sapiens_hsa051600.51635116
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48344793
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46200256
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.44399629
85Malaria_Homo sapiens_hsa051440.43559452
86Salmonella infection_Homo sapiens_hsa051320.42452031
87Endocytosis_Homo sapiens_hsa041440.42125046
88Proteoglycans in cancer_Homo sapiens_hsa052050.40386619
89Other glycan degradation_Homo sapiens_hsa005110.39921488
90Pertussis_Homo sapiens_hsa051330.39131164
91Fanconi anemia pathway_Homo sapiens_hsa034600.39004672
92Renal cell carcinoma_Homo sapiens_hsa052110.37476411
93Choline metabolism in cancer_Homo sapiens_hsa052310.35123400
94Prolactin signaling pathway_Homo sapiens_hsa049170.35080375
95RNA transport_Homo sapiens_hsa030130.35065219
96Legionellosis_Homo sapiens_hsa051340.34294925
97HIF-1 signaling pathway_Homo sapiens_hsa040660.33591534
98Notch signaling pathway_Homo sapiens_hsa043300.33464898
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32054033
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31330251
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30017177
102Systemic lupus erythematosus_Homo sapiens_hsa053220.28518310
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.27908378
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.27581502
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26527037
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26397313
107Type II diabetes mellitus_Homo sapiens_hsa049300.26293903
108Endometrial cancer_Homo sapiens_hsa052130.25944524
109ErbB signaling pathway_Homo sapiens_hsa040120.25455745
110N-Glycan biosynthesis_Homo sapiens_hsa005100.25302433
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24725990
112Long-term potentiation_Homo sapiens_hsa047200.24117885
113RNA degradation_Homo sapiens_hsa030180.23337915
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16525885
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13080962
116Pentose phosphate pathway_Homo sapiens_hsa000300.11835499
117Fructose and mannose metabolism_Homo sapiens_hsa000510.10948617
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09769088
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.04933093
120GnRH signaling pathway_Homo sapiens_hsa049120.04111695
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.01398372
122Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0016710

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