CD79B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* B cell receptor signaling pathway (GO:0050853)8.44673980
2antigen processing and presentation of endogenous antigen (GO:0019883)7.04903345
3positive regulation of gamma-delta T cell activation (GO:0046645)6.94576394
4regulation of B cell receptor signaling pathway (GO:0050855)6.34645737
5regulation of antigen processing and presentation of peptide antigen (GO:0002583)6.30529516
6positive regulation of B cell differentiation (GO:0045579)6.19301024
7cytidine metabolic process (GO:0046087)6.12850564
8cytidine catabolic process (GO:0006216)6.12850564
9cytidine deamination (GO:0009972)6.12850564
10cellular response to zinc ion (GO:0071294)5.95605662
11regulation of B cell differentiation (GO:0045577)5.92182004
12regulation of gamma-delta T cell differentiation (GO:0045586)5.26751279
13B cell proliferation (GO:0042100)5.23266630
14regulation of antigen processing and presentation (GO:0002577)5.07180014
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.98203006
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.98203006
17regulation of dendritic cell antigen processing and presentation (GO:0002604)4.86232184
18regulation of gamma-delta T cell activation (GO:0046643)4.82620460
19negative regulation of cell killing (GO:0031342)4.66814097
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.66814097
21B cell mediated immunity (GO:0019724)4.56272457
22pyrimidine ribonucleoside catabolic process (GO:0046133)4.56071144
23somatic diversification of immune receptors via somatic mutation (GO:0002566)4.50686437
24somatic hypermutation of immunoglobulin genes (GO:0016446)4.50686437
25detection of bacterium (GO:0016045)4.42256196
26mature B cell differentiation (GO:0002335)4.25692825
27positive thymic T cell selection (GO:0045059)4.22454585
28positive regulation of antigen processing and presentation (GO:0002579)4.17006320
29negative regulation of thymocyte apoptotic process (GO:0070244)4.15254204
30regulation of B cell proliferation (GO:0030888)4.14847150
31detection of other organism (GO:0098543)4.14790177
32regulation of B cell apoptotic process (GO:0002902)4.07549398
33negative regulation of B cell proliferation (GO:0030889)4.06743915
34negative regulation of phagocytosis (GO:0050765)4.02151707
35T cell lineage commitment (GO:0002360)3.98322142
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.97335613
37negative regulation of histone methylation (GO:0031061)3.92566674
38negative regulation of T-helper cell differentiation (GO:0045623)3.87040282
39negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.87040282
40B cell activation (GO:0042113)3.85830011
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.78775439
42regulation of superoxide anion generation (GO:0032928)3.78307067
43regulation of histone H3-K9 methylation (GO:0051570)3.78104070
44* antigen receptor-mediated signaling pathway (GO:0050851)3.73010710
45B cell homeostasis (GO:0001782)3.70171805
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.70066313
47lymphocyte homeostasis (GO:0002260)3.66475142
48germinal center formation (GO:0002467)3.62832518
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.61650790
50regulation of interferon-beta biosynthetic process (GO:0045357)3.57624137
51defense response to protozoan (GO:0042832)3.57507265
52negative regulation of B cell apoptotic process (GO:0002903)3.57102144
53T cell homeostasis (GO:0043029)3.55600872
54ribosomal small subunit assembly (GO:0000028)3.55066638
55negative regulation of gene silencing (GO:0060969)3.54581620
56mature B cell differentiation involved in immune response (GO:0002313)3.51904105
57chaperone mediated protein folding requiring cofactor (GO:0051085)3.51380758
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.50782762
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.50782762
60positive regulation by organism of defense response of other organism involved in symbiotic interact3.50782762
61modulation by symbiont of host immune response (GO:0052553)3.50782762
62positive regulation by symbiont of host defense response (GO:0052509)3.50782762
63modulation by symbiont of host defense response (GO:0052031)3.50782762
64negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.50772463
65positive regulation of gene expression, epigenetic (GO:0045815)3.50282882
66cellular response to type I interferon (GO:0071357)3.50267865
67type I interferon signaling pathway (GO:0060337)3.50267865
68response to type I interferon (GO:0034340)3.49059575
69positive regulation of type 2 immune response (GO:0002830)3.48961461
70serine transport (GO:0032329)3.48080757
71* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.46279141
72immunoglobulin mediated immune response (GO:0016064)3.45013090
73positive regulation of B cell proliferation (GO:0030890)3.41064534
74lymph node development (GO:0048535)3.40064214
75B cell differentiation (GO:0030183)3.34297419
76positive regulation of B cell activation (GO:0050871)3.34192675
77regulation of interleukin-12 biosynthetic process (GO:0045075)3.33866073
78immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.33479154
79Fc-gamma receptor signaling pathway (GO:0038094)3.33479154
80Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.33479154
81somatic diversification of immunoglobulins (GO:0016445)3.31848681
82regulation of T-helper 1 cell differentiation (GO:0045625)3.29845984
83Arp2/3 complex-mediated actin nucleation (GO:0034314)3.29273880
84positive regulation of interferon-alpha production (GO:0032727)3.28952030
85Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.28353506
86regulation of B cell activation (GO:0050864)3.26564255
87production of molecular mediator involved in inflammatory response (GO:0002532)3.26260491
88V(D)J recombination (GO:0033151)3.25170196
89regulation of T-helper 2 cell differentiation (GO:0045628)3.21778229
90myeloid cell activation involved in immune response (GO:0002275)3.21747973
91leukocyte homeostasis (GO:0001776)3.21347182
92mast cell activation (GO:0045576)3.20192259
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.20091062
94negative thymic T cell selection (GO:0045060)3.19579037
95positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.18489172
96T cell selection (GO:0045058)3.17739269
97CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.16922422
98positive regulation of immunoglobulin production (GO:0002639)3.16283791
99neutrophil activation (GO:0042119)3.16020898
100regulation of alpha-beta T cell proliferation (GO:0046640)3.15012850
101cellular response to interleukin-15 (GO:0071350)3.13296638
102NIK/NF-kappaB signaling (GO:0038061)3.13242748
103response to interleukin-15 (GO:0070672)3.12940410
104regulation of thymocyte apoptotic process (GO:0070243)3.12752123
105viral transcription (GO:0019083)3.11556281
106T cell migration (GO:0072678)3.10630784
107lymphocyte proliferation (GO:0046651)3.09795192
108negative regulation of lymphocyte apoptotic process (GO:0070229)3.09728872
109T cell costimulation (GO:0031295)3.09678999
110mononuclear cell proliferation (GO:0032943)3.09432164
111leukocyte aggregation (GO:0070486)3.09256328
112lymphocyte costimulation (GO:0031294)3.05795261
113negative regulation of bone resorption (GO:0045779)3.05412525
114somatic diversification of immune receptors (GO:0002200)3.05390047
115regulation of mast cell degranulation (GO:0043304)3.05162444
116positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.04796476
117regulation of interferon-alpha production (GO:0032647)3.04741361
118regulation of chromatin silencing (GO:0031935)3.04219353
119response to protozoan (GO:0001562)3.03789767
120adaptive immune response (GO:0002250)3.03598312
121regulation of interferon-gamma biosynthetic process (GO:0045072)3.03094165
122thymic T cell selection (GO:0045061)3.00055850
123somatic recombination of immunoglobulin gene segments (GO:0016447)2.99957665
124neutrophil activation involved in immune response (GO:0002283)2.99785463
125respiratory burst (GO:0045730)2.99432791
126negative regulation of T cell apoptotic process (GO:0070233)2.99105906
127B cell activation involved in immune response (GO:0002312)2.98575510
128interferon-gamma-mediated signaling pathway (GO:0060333)2.98251656
129positive regulation of Rap GTPase activity (GO:0032854)2.97342193
130L-serine transport (GO:0015825)2.97119693
131mast cell activation involved in immune response (GO:0002279)2.95853981
132mast cell degranulation (GO:0043303)2.95853981
133positive regulation of cell adhesion mediated by integrin (GO:0033630)2.94501469
134negative T cell selection (GO:0043383)2.91481954
135telomere maintenance via semi-conservative replication (GO:0032201)2.90529682
136complement activation, classical pathway (GO:0006958)2.90399160
137histamine secretion (GO:0001821)2.88216640
138translational termination (GO:0006415)2.86858851
139hepatocyte apoptotic process (GO:0097284)2.86846302
140positive T cell selection (GO:0043368)2.83608608
141macrophage activation involved in immune response (GO:0002281)2.83343368
142natural killer cell differentiation (GO:0001779)2.82010390
143mucosal-associated lymphoid tissue development (GO:0048537)2.81677513
144Peyers patch development (GO:0048541)2.81677513
145somatic cell DNA recombination (GO:0016444)2.81482127
146somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.81482127
147regulation of germinal center formation (GO:0002634)2.79999689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.15558649
2E2F7_22180533_ChIP-Seq_HELA_Human6.12042668
3* MYC_22102868_ChIP-Seq_BL_Human4.67152322
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.47800992
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.36392968
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.15685934
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.77891976
8VDR_21846776_ChIP-Seq_THP-1_Human3.37087888
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.34364288
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.08101800
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99474725
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.89969192
13* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.79199983
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.57581277
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46165385
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.44165966
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39588628
18MAF_26560356_Chip-Seq_TH1_Human2.37980012
19MYB_26560356_Chip-Seq_TH2_Human2.32706237
20RUNX_20019798_ChIP-Seq_JUKART_Human2.28775449
21MYB_26560356_Chip-Seq_TH1_Human2.28515925
22CIITA_25753668_ChIP-Seq_RAJI_Human2.28154903
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.26169049
24UTX_26944678_Chip-Seq_JUKART_Human2.22549221
25SCL_19346495_ChIP-Seq_HPC-7_Human2.17308145
26VDR_24763502_ChIP-Seq_THP-1_Human2.15770779
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06257212
28SPI1_23547873_ChIP-Seq_NB4_Human2.04871997
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98239583
30TCF7_22412390_ChIP-Seq_EML_Mouse1.85914644
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85212528
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84711550
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79820070
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78625876
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76880615
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76867926
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69828506
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69492032
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67405425
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67392138
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.65722904
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62764103
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59581341
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59343692
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59277341
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55222130
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54287417
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53793755
49MAF_26560356_Chip-Seq_TH2_Human1.52928408
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50155817
51SPI1_23127762_ChIP-Seq_K562_Human1.49461612
52KDM2B_26808549_Chip-Seq_DND41_Human1.47644777
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47036608
54FOXP3_21729870_ChIP-Seq_TREG_Human1.46159919
55* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46130315
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43410570
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43073037
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37811062
59GATA1_22025678_ChIP-Seq_K562_Human1.36716228
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33725566
61GATA3_27048872_Chip-Seq_THYMUS_Human1.33407384
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33120632
63VDR_23849224_ChIP-Seq_CD4+_Human1.32432851
64PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31797398
65* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28151741
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27289610
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26481765
68BCOR_27268052_Chip-Seq_Bcells_Human1.26326598
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25325397
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.24526617
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.18570566
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17877203
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17832406
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17752633
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17747253
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.17237924
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15024411
78KDM5A_27292631_Chip-Seq_BREAST_Human1.08906627
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07608376
80SMRT_27268052_Chip-Seq_Bcells_Human1.05740339
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03688396
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.03378679
83LXR_22292898_ChIP-Seq_THP-1_Human1.00551695
84XRN2_22483619_ChIP-Seq_HELA_Human0.99230583
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99214552
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98074264
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97012508
88PU_27001747_Chip-Seq_BMDM_Mouse0.94504012
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94422870
90IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93143165
91EST1_17652178_ChIP-ChIP_JURKAT_Human0.92973809
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92621205
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90024459
94MYC_18555785_ChIP-Seq_MESCs_Mouse0.89353309
95P300_27268052_Chip-Seq_Bcells_Human0.89030153
96VDR_24787735_ChIP-Seq_THP-1_Human0.88312414
97SPI1_20517297_ChIP-Seq_HL60_Human0.85812762
98* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85250273
99NCOR1_26117541_ChIP-Seq_K562_Human0.84748304
100GATA3_26560356_Chip-Seq_TH2_Human0.84500270
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84094097
102BCL6_27268052_Chip-Seq_Bcells_Human0.82509078
103MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.81965654
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81823238
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.81685619
106CTCF_21964334_ChIP-Seq_BJAB-B_Human0.81616319
107MYC_19030024_ChIP-ChIP_MESCs_Mouse0.81586960
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80642415
109RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80630248
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80210401
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79659856
112GATA3_26560356_Chip-Seq_TH1_Human0.79561128
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.79291031
114* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78341135
115GABP_17652178_ChIP-ChIP_JURKAT_Human0.77226630
116ELK1_19687146_ChIP-ChIP_HELA_Human0.76439178
117RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75503610
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74804202
119CTCF_26484167_Chip-Seq_Bcells_Mouse0.74342666
120NELFA_20434984_ChIP-Seq_ESCs_Mouse0.73815341
121MYC_18358816_ChIP-ChIP_MESCs_Mouse0.73592574
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73363827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.64525243
2* MP0001800_abnormal_humoral_immune4.94640931
3* MP0001790_abnormal_immune_system4.34655302
4* MP0005387_immune_system_phenotype4.34655302
5MP0000685_abnormal_immune_system4.03697769
6* MP0002452_abnormal_antigen_presenting3.75356708
7MP0003303_peritoneal_inflammation3.32306493
8MP0005000_abnormal_immune_tolerance3.14784281
9* MP0002723_abnormal_immune_serum3.11107665
10* MP0002420_abnormal_adaptive_immunity3.10954760
11MP0005671_abnormal_response_to3.10528910
12* MP0002398_abnormal_bone_marrow3.09156094
13* MP0001819_abnormal_immune_cell3.01060683
14MP0002138_abnormal_hepatobiliary_system2.83164427
15* MP0000716_abnormal_immune_system2.76856995
16* MP0000689_abnormal_spleen_morphology2.74966645
17MP0002396_abnormal_hematopoietic_system2.45061249
18MP0003763_abnormal_thymus_physiology2.42209772
19* MP0002722_abnormal_immune_system2.32561104
20* MP0002429_abnormal_blood_cell2.31626158
21MP0002166_altered_tumor_susceptibility2.26140763
22MP0005025_abnormal_response_to2.13788360
23MP0009785_altered_susceptibility_to2.04295103
24MP0004808_abnormal_hematopoietic_stem1.97291209
25MP0005451_abnormal_body_composition1.96961116
26MP0002148_abnormal_hypersensitivity_rea1.95879752
27MP0003724_increased_susceptibility_to1.94428177
28MP0010094_abnormal_chromosome_stability1.94255224
29MP0002419_abnormal_innate_immunity1.85872600
30MP0008057_abnormal_DNA_replication1.84444519
31MP0000703_abnormal_thymus_morphology1.82137145
32MP0006054_spinal_hemorrhage1.82079499
33MP0003436_decreased_susceptibility_to1.81636629
34MP0003300_gastrointestinal_ulcer1.81375066
35MP0002405_respiratory_system_inflammati1.74244868
36MP0001873_stomach_inflammation1.70396112
37MP0001845_abnormal_inflammatory_respons1.62661752
38MP0010155_abnormal_intestine_physiology1.62506870
39MP0001853_heart_inflammation1.56376715
40MP0003172_abnormal_lysosome_physiology1.54864443
41MP0003077_abnormal_cell_cycle1.53859290
42MP0002006_tumorigenesis1.52031199
43MP0004947_skin_inflammation1.49602405
44MP0002933_joint_inflammation1.43154065
45MP0002019_abnormal_tumor_incidence1.41850856
46MP0003866_abnormal_defecation1.41551610
47MP0004510_myositis1.41251886
48MP0005464_abnormal_platelet_physiology1.39739495
49MP0001879_abnormal_lymphatic_vessel1.34369828
50MP0003693_abnormal_embryo_hatching1.31464709
51MP0009333_abnormal_splenocyte_physiolog1.29130386
52MP0000465_gastrointestinal_hemorrhage1.24458717
53MP0005310_abnormal_salivary_gland1.22885301
54MP0001849_ear_inflammation1.20184698
55MP0003111_abnormal_nucleus_morphology1.17578787
56MP0003183_abnormal_peptide_metabolism1.14426532
57MP0002009_preneoplasia1.12530002
58MP0010352_gastrointestinal_tract_polyps1.07381694
59MP0000490_abnormal_crypts_of1.04234036
60MP0004381_abnormal_hair_follicle1.04228607
61MP0010234_abnormal_vibrissa_follicle1.02039979
62MP0004957_abnormal_blastocyst_morpholog0.96550261
63MP0009278_abnormal_bone_marrow0.96050625
64MP0002136_abnormal_kidney_physiology0.94043831
65MP0002095_abnormal_skin_pigmentation0.93642624
66MP0005397_hematopoietic_system_phenotyp0.93357987
67MP0001545_abnormal_hematopoietic_system0.93357987
68MP0005174_abnormal_tail_pigmentation0.92337434
69MP0002876_abnormal_thyroid_physiology0.91506156
70MP0005645_abnormal_hypothalamus_physiol0.90702217
71MP0008469_abnormal_protein_level0.87424436
72MP0000350_abnormal_cell_proliferation0.86306035
73MP0008058_abnormal_DNA_repair0.85809399
74MP0003252_abnormal_bile_duct0.75229830
75MP0000313_abnormal_cell_death0.74482332
76MP0003091_abnormal_cell_migration0.66327240
77MP0000015_abnormal_ear_pigmentation0.64577089
78MP0001730_embryonic_growth_arrest0.64116102
79MP0005076_abnormal_cell_differentiation0.63956933
80MP0005621_abnormal_cell_physiology0.62878169
81MP0000013_abnormal_adipose_tissue0.62863948
82MP0001986_abnormal_taste_sensitivity0.61122233
83MP0008874_decreased_physiological_sensi0.59693195
84MP0001663_abnormal_digestive_system0.59594546
85MP0010307_abnormal_tumor_latency0.59087190
86MP0003787_abnormal_imprinting0.59019174
87MP0008260_abnormal_autophagy0.57996854
88MP0008007_abnormal_cellular_replicative0.57932035
89MP0004084_abnormal_cardiac_muscle0.57432495
90MP0002083_premature_death0.56159767
91MP0004036_abnormal_muscle_relaxation0.54914276
92MP0005381_digestive/alimentary_phenotyp0.54722489
93MP0008961_abnormal_basal_metabolism0.53980262
94MP0002928_abnormal_bile_duct0.53372224
95MP0001533_abnormal_skeleton_physiology0.53272669
96MP0000858_altered_metastatic_potential0.52892833
97MP0000249_abnormal_blood_vessel0.52809768
98MP0003045_fibrosis0.52059675
99MP0005584_abnormal_enzyme/coenzyme_acti0.51536911
100MP0003943_abnormal_hepatobiliary_system0.48338171
101MP0009931_abnormal_skin_appearance0.48254131
102MP0003566_abnormal_cell_adhesion0.47730223
103MP0006082_CNS_inflammation0.47699974
104MP0001851_eye_inflammation0.47305055
105MP0000477_abnormal_intestine_morphology0.47289895
106MP0008004_abnormal_stomach_pH0.46898770
107MP0009763_increased_sensitivity_to0.46433686
108MP0005075_abnormal_melanosome_morpholog0.44168953
109MP0002132_abnormal_respiratory_system0.44137090
110MP0000372_irregular_coat_pigmentation0.43881101
111MP0005384_cellular_phenotype0.43824981
112MP0003191_abnormal_cellular_cholesterol0.43188399
113MP0004883_abnormal_blood_vessel0.42213178
114MP0008877_abnormal_DNA_methylation0.42155516
115MP0000598_abnormal_liver_morphology0.42031463
116MP0001191_abnormal_skin_condition0.42026464
117MP0002693_abnormal_pancreas_physiology0.41968243
118MP0002998_abnormal_bone_remodeling0.41713882
119MP0002139_abnormal_hepatobiliary_system0.41689217
120MP0009764_decreased_sensitivity_to0.41067415
121MP0005166_decreased_susceptibility_to0.40507605
122MP0000569_abnormal_digit_pigmentation0.40200842
123MP0000470_abnormal_stomach_morphology0.39880927
124MP0001764_abnormal_homeostasis0.39389011
125MP0000609_abnormal_liver_physiology0.34645834
126MP0000371_diluted_coat_color0.33698012

Predicted human phenotypes

RankGene SetZ-score
1* Agammaglobulinemia (HP:0004432)8.80421288
2Gastrointestinal stroma tumor (HP:0100723)7.84924280
3Recurrent sinusitis (HP:0011108)6.42645279
4* Cellulitis (HP:0100658)6.10176034
5Colitis (HP:0002583)5.97876031
6* Papilloma (HP:0012740)5.55009277
7* Verrucae (HP:0200043)5.55009277
8IgM deficiency (HP:0002850)5.31514381
9Recurrent viral infections (HP:0004429)5.27481818
10Panhypogammaglobulinemia (HP:0003139)5.18406452
11B lymphocytopenia (HP:0010976)5.16076761
12Abnormality of B cell number (HP:0010975)5.16076761
13* Recurrent bronchitis (HP:0002837)5.12292327
14Lymphopenia (HP:0001888)5.10667033
15Inflammation of the large intestine (HP:0002037)5.02397089
16Abnormality of cells of the lymphoid lineage (HP:0012140)4.93320410
17Gastrointestinal inflammation (HP:0004386)4.93066304
18Emphysema (HP:0002097)4.63334912
19Small epiphyses (HP:0010585)4.62410418
20* Meningitis (HP:0001287)4.47517571
21Abnormal delayed hypersensitivity skin test (HP:0002963)4.46166710
22Hypoproteinemia (HP:0003075)4.41106564
23Thyroiditis (HP:0100646)4.40325752
24IgA deficiency (HP:0002720)4.19253893
25Chronic otitis media (HP:0000389)4.00549424
26Vasculitis (HP:0002633)3.95491480
27IgG deficiency (HP:0004315)3.83627654
28Restrictive lung disease (HP:0002091)3.70896178
29* Recurrent lower respiratory tract infections (HP:0002783)3.56698126
30* Osteomyelitis (HP:0002754)3.55506368
31Recurrent fungal infections (HP:0002841)3.49279361
32Recurrent gram-negative bacterial infections (HP:0005420)3.24350819
33Hypoplasia of the capital femoral epiphysis (HP:0003090)3.22080606
34* Sepsis (HP:0100806)3.21492853
35Vertebral arch anomaly (HP:0008438)3.21266420
36Mitral stenosis (HP:0001718)3.21216693
37* Recurrent pneumonia (HP:0006532)3.20134482
38* Recurrent otitis media (HP:0000403)3.19595458
39Recurrent abscess formation (HP:0002722)3.17229458
40Abnormality of macrophages (HP:0004311)3.14163435
41Recurrent bacterial skin infections (HP:0005406)3.10199731
42Recurrent cutaneous fungal infections (HP:0011370)3.05548691
43Chronic mucocutaneous candidiasis (HP:0002728)3.05548691
44Lymphoma (HP:0002665)3.05404559
45Leukocytosis (HP:0001974)3.03453260
46Abnormality of T cell physiology (HP:0011840)3.03320669
47Abnormality of T cells (HP:0002843)3.03031462
48Autoimmune thrombocytopenia (HP:0001973)2.95712954
49Flattened epiphyses (HP:0003071)2.94472999
50Abnormality of the fingertips (HP:0001211)2.92737695
51Leukopenia (HP:0001882)2.89488072
52Abnormality of T cell number (HP:0011839)2.84596000
53T lymphocytopenia (HP:0005403)2.82370446
54Thrombocytosis (HP:0001894)2.81563927
55* Bronchitis (HP:0012387)2.80931260
56Abnormality of the prostate (HP:0008775)2.78189597
57Viral hepatitis (HP:0006562)2.73073553
58Combined immunodeficiency (HP:0005387)2.65146305
59Mediastinal lymphadenopathy (HP:0100721)2.64914335
60Recurrent skin infections (HP:0001581)2.61349310
61Elevated erythrocyte sedimentation rate (HP:0003565)2.58209209
62Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.55644938
63Absent epiphyses (HP:0010577)2.55644938
64Neutropenia (HP:0001875)2.55192539
65Abnormality of the intervertebral disk (HP:0005108)2.49647428
66Severe combined immunodeficiency (HP:0004430)2.49005393
67Irregular vertebral endplates (HP:0003301)2.45938030
68Hypoplasia of the thymus (HP:0000778)2.35961617
69Ulnar bowing (HP:0003031)2.34487262
70Interstitial pulmonary disease (HP:0006530)2.33188572
71* Skin rash (HP:0000988)2.32534587
72* Chronic sinusitis (HP:0011109)2.32530684
73Erythroderma (HP:0001019)2.26569764
74Urticaria (HP:0001025)2.25319202
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25147611
76Encephalitis (HP:0002383)2.24868776
77Eosinophilia (HP:0001880)2.21864222
78Gastrointestinal infarctions (HP:0005244)2.21450210
79Arthropathy (HP:0003040)2.20299905
80Chronic diarrhea (HP:0002028)2.18810968
81Stomatitis (HP:0010280)2.16874065
82Myositis (HP:0100614)2.07765493
83Nasal polyposis (HP:0100582)2.06688960
84Spontaneous hematomas (HP:0007420)2.06536982
85* Skin ulcer (HP:0200042)2.04577292
86Eczematoid dermatitis (HP:0000976)2.02511199
87Obstructive lung disease (HP:0006536)2.02276802
88Chronic obstructive pulmonary disease (HP:0006510)2.02276802
89Increased IgE level (HP:0003212)2.02238251
90Basal cell carcinoma (HP:0002671)2.01707672
91Chest pain (HP:0100749)2.00593264
92Granulocytopenia (HP:0001913)1.99724130
93Abnormality of the pleura (HP:0002103)1.99235239
94Increased IgM level (HP:0003496)1.95644888
95Papilledema (HP:0001085)1.92778334
96Pustule (HP:0200039)1.92734407
97Autoimmune hemolytic anemia (HP:0001890)1.92505855
98Abnormality of the peritoneum (HP:0002585)1.91122591
99Arthralgia (HP:0002829)1.89491949
100Fatigue (HP:0012378)1.87663060
101Optic neuritis (HP:0100653)1.87423438
102Retrobulbar optic neuritis (HP:0100654)1.87423438
103Gingivitis (HP:0000230)1.84895798
104Abnormality of eosinophils (HP:0001879)1.82434832
105Prolonged bleeding time (HP:0003010)1.81412508
106Abnormality of the vertebral endplates (HP:0005106)1.79848246
107Aplasia/Hypoplasia of the thymus (HP:0010515)1.79359492
108Orchitis (HP:0100796)1.77048025
109Prostate neoplasm (HP:0100787)1.75755509
110Abnormality of male internal genitalia (HP:0000022)1.74023272
111Barrel-shaped chest (HP:0001552)1.73763620
112Abnormality of the nasal mucosa (HP:0000433)1.73500570
113Limited elbow extension (HP:0001377)1.73500090
114Pulmonary fibrosis (HP:0002206)1.72222765
115Cellular immunodeficiency (HP:0005374)1.70189861
116Hematochezia (HP:0002573)1.70059338
117Reticulocytopenia (HP:0001896)1.68770915
118Aortic regurgitation (HP:0001659)1.68338873
119Pulmonary infiltrates (HP:0002113)1.66381577
120Hemoptysis (HP:0002105)1.66345307
121Epistaxis (HP:0000421)1.64471337
122Hypochromic anemia (HP:0001931)1.63567780
123Progressive external ophthalmoplegia (HP:0000590)1.63022374
124Hypergammaglobulinemia (HP:0010702)1.62067254
125Hepatitis (HP:0012115)1.61931832
126Petechiae (HP:0000967)1.60593043
127Villous atrophy (HP:0011473)1.60365773
128Abnormality of small intestinal villus morphology (HP:0011472)1.60365773
129Keratoconjunctivitis sicca (HP:0001097)1.57503907
130Abnormality of the thymus (HP:0000777)1.57442976
131Hypertensive crisis (HP:0100735)1.57336862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.52488618
2MAP3K105.40454704
3GRK63.66895853
4ERN13.43865856
5BLK3.13939676
6SYK3.01523439
7CSF1R2.95831171
8BTK2.71874001
9RIPK42.30335229
10LRRK22.16435326
11STK102.14473176
12EEF2K1.96829445
13SIK21.76647360
14PRPF4B1.67774024
15MAP3K131.64128133
16* LYN1.57703374
17TYK21.56456141
18MAP3K141.53787105
19BMPR21.50884090
20EIF2AK31.47911338
21KIT1.45509512
22CLK11.35636355
23NEK21.31005615
24HCK1.30650837
25CDK121.27658476
26TBK11.26235789
27MST41.26157134
28TEC1.25100240
29TLK11.19882012
30JAK11.18893106
31TXK1.18050992
32PIK3CG1.16114510
33FES1.15496896
34TAOK31.15392125
35CDK81.14245821
36MAP3K111.13354655
37CSK1.12549093
38ITK1.12539632
39PIM11.07987749
40ZAP701.07114054
41PRKCH1.06679190
42STK41.06436512
43CDK41.03727107
44GRK11.02150651
45KDR1.00817776
46MARK31.00331588
47PRKCQ0.99706368
48IKBKB0.98900973
49BMPR1B0.98130862
50MATK0.89047220
51TRIB30.89020565
52SMG10.87830531
53ARAF0.85942107
54SIK30.85293730
55RPS6KA40.84854992
56JAK30.83239316
57TNK20.81917754
58IRAK40.79838653
59IKBKE0.78606331
60* LCK0.77133376
61BRD40.75139798
62CDC70.74765534
63CCNB10.74669550
64TGFBR20.71651299
65TAOK10.69639379
66PKN20.69015421
67RPS6KB20.68960351
68IRAK30.68137652
69FGFR30.67212874
70CDK90.65294419
71HIPK20.64388344
72MAPK120.64146939
73MAPK70.63687420
74DYRK1B0.61266524
75BUB10.59366419
76MELK0.59356176
77MARK20.56927478
78PRKCI0.56830494
79PRKD20.55470489
80DYRK30.54495188
81TESK20.53929046
82MAP2K30.53711025
83MAPK40.53582189
84MAP3K80.53476982
85SCYL20.53174482
86SIK10.52816266
87MAPK110.51530517
88ALK0.50945376
89RPS6KC10.49227841
90RPS6KL10.49227841
91CDC42BPA0.48735356
92CHUK0.48201368
93MAP3K30.48042627
94JAK20.47717730
95MAP3K10.46745568
96MAP3K70.46724381
97TAOK20.46618406
98PRKD10.46176227
99MAP2K20.45440906
100CDK190.45426024
101ABL10.45110463
102FRK0.44370131
103RPS6KB10.43352801
104NLK0.42369853
105RPS6KA60.42183966
106ATR0.41162188
107PDK10.40824996
108MAPKAPK30.39687998
109EIF2AK10.38523004
110INSR0.38479151
111PASK0.37959493
112CHEK10.35739044
113PRKCD0.35569421
114CDK70.35219411
115MAP2K10.31373327
116CSNK1A1L0.31368559
117CSNK1G10.31366236
118FGR0.30022877
119FGFR40.29762435
120DAPK10.29145005
121CSNK1D0.29011716
122PDPK10.27528146
123AURKB0.26850635
124TGFBR10.26403486
125MAPK30.26160882
126CSNK1G30.25200923
127MAPKAPK20.24550111
128WNK10.24507779
129MAPK130.24018097
130* FYN0.23083685

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.94326739
2* B cell receptor signaling pathway_Homo sapiens_hsa046625.49243788
3Autoimmune thyroid disease_Homo sapiens_hsa053204.08568294
4Graft-versus-host disease_Homo sapiens_hsa053323.95801008
5Type I diabetes mellitus_Homo sapiens_hsa049403.33385184
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.04677654
7Base excision repair_Homo sapiens_hsa034102.84153554
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.70872938
9DNA replication_Homo sapiens_hsa030302.64687601
10Staphylococcus aureus infection_Homo sapiens_hsa051502.59718425
11Mismatch repair_Homo sapiens_hsa034302.59659834
12Hematopoietic cell lineage_Homo sapiens_hsa046402.55364522
13Non-homologous end-joining_Homo sapiens_hsa034502.48906936
14Antigen processing and presentation_Homo sapiens_hsa046122.21466686
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.14407384
16Osteoclast differentiation_Homo sapiens_hsa043801.88881372
17Ribosome_Homo sapiens_hsa030101.79853024
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.78480662
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66398388
20Leishmaniasis_Homo sapiens_hsa051401.61065689
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58517123
22Herpes simplex infection_Homo sapiens_hsa051681.43664206
23Homologous recombination_Homo sapiens_hsa034401.41597099
24T cell receptor signaling pathway_Homo sapiens_hsa046601.40185012
25Epstein-Barr virus infection_Homo sapiens_hsa051691.37748674
26Measles_Homo sapiens_hsa051621.33029447
27Rheumatoid arthritis_Homo sapiens_hsa053231.31889325
28Non-small cell lung cancer_Homo sapiens_hsa052231.26553320
29Systemic lupus erythematosus_Homo sapiens_hsa053221.23117268
30Nucleotide excision repair_Homo sapiens_hsa034201.20164755
31Tuberculosis_Homo sapiens_hsa051521.17949504
32Chemokine signaling pathway_Homo sapiens_hsa040621.16440010
33Spliceosome_Homo sapiens_hsa030401.16289181
34Viral carcinogenesis_Homo sapiens_hsa052031.11320956
35Shigellosis_Homo sapiens_hsa051311.11204782
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.08335645
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07013489
38Platelet activation_Homo sapiens_hsa046111.05280873
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04527312
40Hepatitis B_Homo sapiens_hsa051611.03885324
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02262288
42Chronic myeloid leukemia_Homo sapiens_hsa052200.97384994
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93432884
44Apoptosis_Homo sapiens_hsa042100.93380925
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90954400
46Pancreatic cancer_Homo sapiens_hsa052120.89667371
47Influenza A_Homo sapiens_hsa051640.89441796
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88310179
49Phagosome_Homo sapiens_hsa041450.88099295
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.85459656
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.85191907
52HTLV-I infection_Homo sapiens_hsa051660.85036277
53Toxoplasmosis_Homo sapiens_hsa051450.83966976
54Cell cycle_Homo sapiens_hsa041100.82004785
55Acute myeloid leukemia_Homo sapiens_hsa052210.80987715
56Fanconi anemia pathway_Homo sapiens_hsa034600.76284938
57Viral myocarditis_Homo sapiens_hsa054160.75530495
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74143711
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68994590
60p53 signaling pathway_Homo sapiens_hsa041150.68517944
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64075986
62African trypanosomiasis_Homo sapiens_hsa051430.62661995
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62107720
64Small cell lung cancer_Homo sapiens_hsa052220.60867292
65Alcoholism_Homo sapiens_hsa050340.59947571
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56062255
67mRNA surveillance pathway_Homo sapiens_hsa030150.56048134
68Pyrimidine metabolism_Homo sapiens_hsa002400.55946227
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54984585
70VEGF signaling pathway_Homo sapiens_hsa043700.54367104
71RNA transport_Homo sapiens_hsa030130.49935368
72MicroRNAs in cancer_Homo sapiens_hsa052060.49318176
73TNF signaling pathway_Homo sapiens_hsa046680.48825682
74Glioma_Homo sapiens_hsa052140.47952685
75Pertussis_Homo sapiens_hsa051330.47005863
76Allograft rejection_Homo sapiens_hsa053300.46937441
77FoxO signaling pathway_Homo sapiens_hsa040680.46876352
78Salmonella infection_Homo sapiens_hsa051320.46458279
79Legionellosis_Homo sapiens_hsa051340.45955180
80Other glycan degradation_Homo sapiens_hsa005110.45597972
81Hepatitis C_Homo sapiens_hsa051600.44409117
82Inositol phosphate metabolism_Homo sapiens_hsa005620.43838040
83RNA degradation_Homo sapiens_hsa030180.42163820
84Malaria_Homo sapiens_hsa051440.41859016
85Colorectal cancer_Homo sapiens_hsa052100.40580663
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39161120
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39069476
88mTOR signaling pathway_Homo sapiens_hsa041500.38679673
89Lysine degradation_Homo sapiens_hsa003100.38328449
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38030409
91Pentose phosphate pathway_Homo sapiens_hsa000300.37886098
92MAPK signaling pathway_Homo sapiens_hsa040100.36594470
93N-Glycan biosynthesis_Homo sapiens_hsa005100.36169698
94Insulin resistance_Homo sapiens_hsa049310.35237436
95Asthma_Homo sapiens_hsa053100.32578432
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32542604
97Endocytosis_Homo sapiens_hsa041440.31488013
98Prostate cancer_Homo sapiens_hsa052150.30568583
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28314488
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27454586
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.23782062
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23474100
103Notch signaling pathway_Homo sapiens_hsa043300.23462026
104RNA polymerase_Homo sapiens_hsa030200.23249848
105One carbon pool by folate_Homo sapiens_hsa006700.22933706
106Renal cell carcinoma_Homo sapiens_hsa052110.22871239
107Proteoglycans in cancer_Homo sapiens_hsa052050.20245619
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19401690
109HIF-1 signaling pathway_Homo sapiens_hsa040660.18497441
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17973971
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17745966
112Caffeine metabolism_Homo sapiens_hsa002320.17367006
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17288980
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.16516647
115Prolactin signaling pathway_Homo sapiens_hsa049170.14877176
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.13458590
117Choline metabolism in cancer_Homo sapiens_hsa052310.11678003
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09717020
119Arachidonic acid metabolism_Homo sapiens_hsa005900.06815305
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.00503281

Most similar genes based on co-expression Upload to Enrichr

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