CD80

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of dendritic cell antigen processing and presentation (GO:0002604)5.55586013
2regulation of chronic inflammatory response (GO:0002676)4.97261019
3regulation of activation of Janus kinase activity (GO:0010533)4.88734445
4response to peptidoglycan (GO:0032494)4.86812210
5* regulation of T-helper 1 cell differentiation (GO:0045625)4.86258422
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78265374
7CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.71407403
8regulation of vitamin D biosynthetic process (GO:0060556)4.70951812
9neutrophil activation involved in immune response (GO:0002283)4.68976895
10antigen processing and presentation of endogenous antigen (GO:0019883)4.66184182
11positive regulation of interleukin-12 production (GO:0032735)4.63777461
12negative regulation of interleukin-12 production (GO:0032695)4.54496811
13NIK/NF-kappaB signaling (GO:0038061)4.52231506
14positive regulation of interferon-alpha production (GO:0032727)4.48162576
15positive regulation of antigen processing and presentation (GO:0002579)4.44856882
16positive regulation of type 2 immune response (GO:0002830)4.42023386
17T cell migration (GO:0072678)4.39012355
18response to muramyl dipeptide (GO:0032495)4.29028951
19regulation of interferon-alpha production (GO:0032647)4.25267144
20* positive regulation of T-helper cell differentiation (GO:0045624)4.24713114
21regulation of T-helper 2 cell differentiation (GO:0045628)4.22344176
22myeloid dendritic cell differentiation (GO:0043011)4.13969828
23regulation of memory T cell differentiation (GO:0043380)4.12191753
24regulation of interferon-gamma biosynthetic process (GO:0045072)4.11019550
25regulation of antigen processing and presentation (GO:0002577)4.06597875
26positive regulation of natural killer cell differentiation (GO:0032825)4.02460918
27response to protozoan (GO:0001562)3.94289752
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.87523378
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.87523378
30granulocyte activation (GO:0036230)3.86695596
31positive regulation of defense response to virus by host (GO:0002230)3.85808777
32regulation of cytokine secretion involved in immune response (GO:0002739)3.85249192
33* positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.81333900
34neutrophil activation (GO:0042119)3.79333051
35regulation of interleukin-12 biosynthetic process (GO:0045075)3.76470778
36* positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.74940326
37positive regulation by symbiont of host defense response (GO:0052509)3.74316504
38modulation by symbiont of host defense response (GO:0052031)3.74316504
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.74316504
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.74316504
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.74316504
42modulation by symbiont of host immune response (GO:0052553)3.74316504
43T-helper 1 type immune response (GO:0042088)3.73560122
44regulation of interleukin-12 production (GO:0032655)3.73246287
45type I interferon signaling pathway (GO:0060337)3.72696362
46cellular response to type I interferon (GO:0071357)3.72696362
47cellular response to interferon-beta (GO:0035458)3.70225943
48cellular response to exogenous dsRNA (GO:0071360)3.69961721
49cellular response to interferon-gamma (GO:0071346)3.69797434
50myeloid dendritic cell activation (GO:0001773)3.69582755
51response to type I interferon (GO:0034340)3.68527785
52negative regulation of interleukin-17 production (GO:0032700)3.67918955
53regulation of vitamin metabolic process (GO:0030656)3.67231104
54natural killer cell mediated immunity (GO:0002228)3.64979915
55natural killer cell mediated cytotoxicity (GO:0042267)3.64979915
56regulation of RIG-I signaling pathway (GO:0039535)3.63775772
57negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.63244515
58regulation of T cell tolerance induction (GO:0002664)3.62532333
59* regulation of T-helper cell differentiation (GO:0045622)3.61103959
60positive regulation of interleukin-17 production (GO:0032740)3.57677889
61germinal center formation (GO:0002467)3.57603969
62lipopolysaccharide-mediated signaling pathway (GO:0031663)3.57413521
63immunoglobulin mediated immune response (GO:0016064)3.52683141
64T cell lineage commitment (GO:0002360)3.49450385
65regulation of interleukin-17 production (GO:0032660)3.49152497
66positive regulation of gamma-delta T cell activation (GO:0046645)3.49133355
67* positive regulation of alpha-beta T cell proliferation (GO:0046641)3.49060706
68positive regulation of monocyte chemotaxis (GO:0090026)3.44167711
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.43462205
70dendritic cell differentiation (GO:0097028)3.42317908
71negative regulation of interleukin-10 production (GO:0032693)3.41462193
72response to interferon-gamma (GO:0034341)3.41353307
73negative regulation of viral genome replication (GO:0045071)3.37592387
74regulation of immunoglobulin secretion (GO:0051023)3.35226444
75regulation of interleukin-10 production (GO:0032653)3.34196828
76negative regulation of myeloid cell apoptotic process (GO:0033033)3.32191013
77positive regulation of activated T cell proliferation (GO:0042104)3.31163977
78positive regulation of NF-kappaB import into nucleus (GO:0042346)3.30736109
79regulation of type I interferon-mediated signaling pathway (GO:0060338)3.30468721
80regulation of inflammatory response to antigenic stimulus (GO:0002861)3.29047265
81* regulation of alpha-beta T cell proliferation (GO:0046640)3.27418264
82regulation of B cell receptor signaling pathway (GO:0050855)3.26745203
83response to interferon-beta (GO:0035456)3.26510613
84regulation of podosome assembly (GO:0071801)3.26432547
85eosinophil chemotaxis (GO:0048245)3.25897402
86* regulation of T-helper 1 type immune response (GO:0002825)3.25863024
87positive regulation of T cell cytokine production (GO:0002726)3.25463888
88* positive regulation of interleukin-2 production (GO:0032743)3.24786037
89monocyte chemotaxis (GO:0002548)3.24143817
90* regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.23261302
91interferon-gamma-mediated signaling pathway (GO:0060333)3.21036800
92positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.20817524
93regulation of gamma-delta T cell activation (GO:0046643)3.20759288
94positive regulation of interleukin-10 production (GO:0032733)3.20123508
95regulation of type 2 immune response (GO:0002828)3.20009566
96positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.19221891
97positive regulation of interferon-beta production (GO:0032728)3.18383701
98B cell proliferation (GO:0042100)3.17774790
99* positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.17436591
100positive regulation of heat generation (GO:0031652)3.14951468
101* positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.14711170
102* regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.12621267
103regulation of interferon-beta biosynthetic process (GO:0045357)3.12060310
104kynurenine metabolic process (GO:0070189)3.11493548
105regulation of fever generation (GO:0031620)3.10625692
106negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10134406
107negative regulation of cell killing (GO:0031342)3.10134406
108positive regulation of humoral immune response (GO:0002922)3.10081584
109positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.09408835
110regulation of hypersensitivity (GO:0002883)3.09029210
111regulation of mononuclear cell migration (GO:0071675)3.08162647
112* regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.08085853
113regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07743053
114regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.04044895
115regulation of defense response to virus by host (GO:0050691)3.03864571
116regulation of tolerance induction (GO:0002643)3.03778724
117respiratory burst (GO:0045730)3.03596785
118cytokine secretion (GO:0050663)3.03150255
119positive regulation of B cell mediated immunity (GO:0002714)3.01215155
120positive regulation of immunoglobulin mediated immune response (GO:0002891)3.01215155
121regulation of T cell cytokine production (GO:0002724)3.01111554
122B cell receptor signaling pathway (GO:0050853)2.99110473
123eosinophil migration (GO:0072677)2.98821527
124regulation of interleukin-8 biosynthetic process (GO:0045414)2.98502485
125indolalkylamine catabolic process (GO:0046218)2.97873094
126tryptophan catabolic process (GO:0006569)2.97873094
127indole-containing compound catabolic process (GO:0042436)2.97873094
128negative thymic T cell selection (GO:0045060)2.96788818
129positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.95521458
130regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95409812
131natural killer cell activation involved in immune response (GO:0002323)2.94495491
132macrophage activation involved in immune response (GO:0002281)2.94172384
133defense response to protozoan (GO:0042832)2.93103068
134regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.92986373
135leukocyte aggregation (GO:0070486)2.92680685
136negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.92176518
137regulation of growth of symbiont in host (GO:0044126)2.92176518
138* positive regulation of T-helper 1 type immune response (GO:0002827)2.90998288
139T cell activation involved in immune response (GO:0002286)2.90298212
140positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.89469247
141response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.88020782
142response to host immune response (GO:0052572)2.88020782
143positive regulation of response to biotic stimulus (GO:0002833)2.87822976
144positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.87407837
145B cell mediated immunity (GO:0019724)2.87406792
146natural killer cell activation (GO:0030101)2.86419409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.15862989
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.77377289
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.80271862
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.85596660
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.57374104
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.55327630
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.15322889
8* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.78360072
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.67458581
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.61603463
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.54455977
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.31780517
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.18820235
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.01004563
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00518881
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.87483541
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.80868311
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68486460
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.60190384
20GATA1_22025678_ChIP-Seq_K562_Human2.57514792
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41376024
22MYC_22102868_ChIP-Seq_BL_Human2.37503128
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.15068280
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11722595
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04341696
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92325910
27MYB_26560356_Chip-Seq_TH2_Human1.91185084
28SPI1_23547873_ChIP-Seq_NB4_Human1.85973951
29VDR_24787735_ChIP-Seq_THP-1_Human1.82498462
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73954200
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73783537
32RUNX_20019798_ChIP-Seq_JUKART_Human1.72428153
33MAF_26560356_Chip-Seq_TH1_Human1.69770418
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67753339
35PU_27001747_Chip-Seq_BMDM_Mouse1.62727829
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59846158
37VDR_24763502_ChIP-Seq_THP-1_Human1.52828436
38MYB_26560356_Chip-Seq_TH1_Human1.51852559
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51616290
40SPI1_23127762_ChIP-Seq_K562_Human1.45749587
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45214693
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40192067
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38050045
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.37164357
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26526415
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25038314
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23652970
48VDR_21846776_ChIP-Seq_THP-1_Human1.20375519
49GATA3_27048872_Chip-Seq_THYMUS_Human1.18660802
50CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18112400
51CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17580260
52SCL_19346495_ChIP-Seq_HPC-7_Human1.16868485
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15262849
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13744825
55GATA3_26560356_Chip-Seq_TH2_Human1.12778843
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07826637
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05510855
58TFEB_21752829_ChIP-Seq_HELA_Human1.04887231
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.04694527
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00901841
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96349949
62SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96349949
63CIITA_25753668_ChIP-Seq_RAJI_Human0.95420701
64UTX_26944678_Chip-Seq_JUKART_Human0.95314639
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93629264
66EGR1_19032775_ChIP-ChIP_M12_Human0.93488589
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93273725
68PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92573452
69GATA1_19941826_ChIP-Seq_K562_Human0.92314787
70TCF7_22412390_ChIP-Seq_EML_Mouse0.91948896
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90760959
72GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89473605
73* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88692673
74* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88110236
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87706259
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87162637
77ELK3_25401928_ChIP-Seq_HUVEC_Human0.86407927
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85651282
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85585623
80MAF_26560356_Chip-Seq_TH2_Human0.85238326
81GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84333250
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84233565
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83779137
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83436786
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82582614
86SMRT_27268052_Chip-Seq_Bcells_Human0.81103534
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80683001
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79517396
89STAT1_20625510_ChIP-Seq_HELA_Human0.79484378
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79403089
91CJUN_26792858_Chip-Seq_BT549_Human0.79175313
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79008823
93FOXO3_23340844_ChIP-Seq_DLD1_Human0.78650756
94SOX2_20726797_ChIP-Seq_SW620_Human0.76225754
95NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76048661
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76048661
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73371162
98TRIM28_21343339_ChIP-Seq_HEK293_Human0.73091744
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72316674
100* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72295503
101RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72183298
102LXR_22292898_ChIP-Seq_THP-1_Human0.71821009
103IKZF1_21737484_ChIP-ChIP_HCT116_Human0.71323916
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.70898056
105NCOR1_26117541_ChIP-Seq_K562_Human0.70451463
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.69249183
107* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67956049
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67641188
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.67501136
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64549436
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64276054
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.63642506
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.63364840
114KDM2B_26808549_Chip-Seq_DND41_Human0.63226969
115BCL6_27268052_Chip-Seq_Bcells_Human0.62293172
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.60768326
117CDX2_19796622_ChIP-Seq_MESCs_Mouse0.60557915
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.60307275
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60192217
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59310981
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.58913949
122GATA2_19941826_ChIP-Seq_K562_Human0.58853706
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.58206613
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58089232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.00277488
2MP0009785_altered_susceptibility_to4.02001928
3MP0003436_decreased_susceptibility_to3.89332168
4MP0002148_abnormal_hypersensitivity_rea3.87129910
5MP0000685_abnormal_immune_system3.72459729
6MP0006082_CNS_inflammation3.52879836
7* MP0005000_abnormal_immune_tolerance3.27329550
8MP0001790_abnormal_immune_system3.15441518
9MP0005387_immune_system_phenotype3.15441518
10MP0005671_abnormal_response_to3.13554881
11MP0002254_reproductive_system_inflammat2.95383966
12MP0001348_abnormal_lacrimal_gland2.92367389
13MP0005025_abnormal_response_to2.90546469
14MP0002419_abnormal_innate_immunity2.89497220
15MP0003303_peritoneal_inflammation2.85381487
16MP0004510_myositis2.84812977
17* MP0002452_abnormal_antigen_presenting2.62459314
18* MP0001800_abnormal_humoral_immune2.59319151
19* MP0002723_abnormal_immune_serum2.51647057
20MP0002138_abnormal_hepatobiliary_system2.35833630
21MP0003724_increased_susceptibility_to2.32951973
22* MP0001819_abnormal_immune_cell2.25938838
23* MP0002420_abnormal_adaptive_immunity2.20986458
24MP0002006_tumorigenesis2.16314944
25MP0005310_abnormal_salivary_gland2.09818156
26MP0005451_abnormal_body_composition2.01294332
27MP0001853_heart_inflammation1.97195078
28MP0001533_abnormal_skeleton_physiology1.93438093
29MP0002405_respiratory_system_inflammati1.89898018
30MP0009764_decreased_sensitivity_to1.87022985
31MP0002139_abnormal_hepatobiliary_system1.84877326
32MP0004947_skin_inflammation1.80692984
33MP0001346_abnormal_lacrimal_gland1.80527921
34MP0003448_altered_tumor_morphology1.78806899
35MP0010155_abnormal_intestine_physiology1.75132379
36* MP0001845_abnormal_inflammatory_respons1.73383515
37MP0002166_altered_tumor_susceptibility1.71191097
38* MP0000716_abnormal_immune_system1.66393336
39MP0002163_abnormal_gland_morphology1.59000252
40* MP0002398_abnormal_bone_marrow1.58718517
41MP0005464_abnormal_platelet_physiology1.58050235
42MP0008469_abnormal_protein_level1.50172066
43MP0010352_gastrointestinal_tract_polyps1.47791489
44MP0000858_altered_metastatic_potential1.44860228
45MP0005076_abnormal_cell_differentiation1.39589142
46MP0005058_abnormal_lysosome_morphology1.35243877
47MP0009278_abnormal_bone_marrow1.33558817
48MP0000569_abnormal_digit_pigmentation1.32319212
49MP0001873_stomach_inflammation1.31672250
50* MP0002429_abnormal_blood_cell1.30318187
51MP0009333_abnormal_splenocyte_physiolog1.29649941
52MP0002277_abnormal_respiratory_mucosa1.28944221
53MP0000343_altered_response_to1.25665694
54MP0003091_abnormal_cell_migration1.23105670
55MP0003453_abnormal_keratinocyte_physiol1.23052908
56MP0003075_altered_response_to1.20988968
57MP0005397_hematopoietic_system_phenotyp1.17960185
58MP0001545_abnormal_hematopoietic_system1.17960185
59MP0002332_abnormal_exercise_endurance1.13295249
60* MP0000689_abnormal_spleen_morphology1.12612666
61* MP0002722_abnormal_immune_system1.10729460
62MP0002998_abnormal_bone_remodeling1.05862506
63MP0003763_abnormal_thymus_physiology1.05648805
64MP0002933_joint_inflammation0.99407088
65MP0005390_skeleton_phenotype0.98926993
66MP0003300_gastrointestinal_ulcer0.94335872
67MP0003566_abnormal_cell_adhesion0.94125839
68MP0009840_abnormal_foam_cell0.93869722
69MP0003828_pulmonary_edema0.91517478
70MP0008057_abnormal_DNA_replication0.90208579
71MP0003172_abnormal_lysosome_physiology0.89848398
72MP0005166_decreased_susceptibility_to0.89373664
73MP0008438_abnormal_cutaneous_collagen0.89158065
74MP0009763_increased_sensitivity_to0.89033342
75MP0002877_abnormal_melanocyte_morpholog0.88725329
76MP0003183_abnormal_peptide_metabolism0.88572344
77MP0003656_abnormal_erythrocyte_physiolo0.86685819
78MP0003191_abnormal_cellular_cholesterol0.84519185
79MP0010307_abnormal_tumor_latency0.82517406
80MP0008874_decreased_physiological_sensi0.79044105
81MP0003195_calcinosis0.76950032
82MP0005164_abnormal_response_to0.76424939
83MP0003806_abnormal_nucleotide_metabolis0.75388042
84MP0000604_amyloidosis0.74588769
85MP0005023_abnormal_wound_healing0.72009882
86MP0004782_abnormal_surfactant_physiolog0.70823851
87MP0000767_abnormal_smooth_muscle0.69831919
88MP0000703_abnormal_thymus_morphology0.69381345
89MP0000249_abnormal_blood_vessel0.68744647
90MP0002009_preneoplasia0.68192152
91MP0003690_abnormal_glial_cell0.66115890
92MP0001851_eye_inflammation0.66097580
93MP0003045_fibrosis0.64394841
94MP0005647_abnormal_sex_gland0.64128480
95MP0003646_muscle_fatigue0.63090794
96MP0005167_abnormal_blood-brain_barrier0.62158406
97MP0004808_abnormal_hematopoietic_stem0.61287038
98MP0005379_endocrine/exocrine_gland_phen0.60596865
99MP0000627_abnormal_mammary_gland0.60104524
100MP0003705_abnormal_hypodermis_morpholog0.59563650
101MP0000609_abnormal_liver_physiology0.59522613
102MP0002019_abnormal_tumor_incidence0.59455389
103* MP0002693_abnormal_pancreas_physiology0.59050332
104MP0009765_abnormal_xenobiotic_induced0.58952652
105MP0005165_increased_susceptibility_to0.56936735
106MP0000371_diluted_coat_color0.56729912
107MP0001881_abnormal_mammary_gland0.55396021
108MP0005535_abnormal_body_temperature0.55009412
109MP0008004_abnormal_stomach_pH0.54889791
110MP0000490_abnormal_crypts_of0.53149616
111MP0002136_abnormal_kidney_physiology0.52393062
112MP0000920_abnormal_myelination0.51628553
113MP0001663_abnormal_digestive_system0.50849021
114MP0001727_abnormal_embryo_implantation0.50345655
115MP0003866_abnormal_defecation0.49936041
116MP0005645_abnormal_hypothalamus_physiol0.49688314
117MP0009115_abnormal_fat_cell0.48903697

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.54786626
2Eczematoid dermatitis (HP:0000976)6.49205540
3Recurrent bacterial skin infections (HP:0005406)6.00642816
4Retrobulbar optic neuritis (HP:0100654)5.28250120
5Optic neuritis (HP:0100653)5.28250120
6Recurrent gram-negative bacterial infections (HP:0005420)5.27986531
7Myositis (HP:0100614)5.15459580
8Orchitis (HP:0100796)5.08211474
9Gastrointestinal stroma tumor (HP:0100723)5.02736406
10Elevated erythrocyte sedimentation rate (HP:0003565)4.96128347
11Mediastinal lymphadenopathy (HP:0100721)4.83772439
12Increased IgM level (HP:0003496)4.80305941
13Recurrent fungal infections (HP:0002841)4.53810618
14Abnormality of macrophages (HP:0004311)4.49723293
15Autoimmune thrombocytopenia (HP:0001973)4.16058303
16Recurrent skin infections (HP:0001581)4.14215658
17Vasculitis (HP:0002633)4.02143564
18Abnormality of liposaccharide metabolism (HP:0010968)3.90456228
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.90456228
20Abnormality of glycolipid metabolism (HP:0010969)3.90456228
21Stomatitis (HP:0010280)3.90026289
22Recurrent cutaneous fungal infections (HP:0011370)3.81204330
23Chronic mucocutaneous candidiasis (HP:0002728)3.81204330
24Recurrent viral infections (HP:0004429)3.70830674
25Chronic otitis media (HP:0000389)3.70535299
26Basal ganglia calcification (HP:0002135)3.68106830
27Gingivitis (HP:0000230)3.66181780
28Systemic lupus erythematosus (HP:0002725)3.55377811
29Keratoconjunctivitis (HP:0001096)3.49605442
30Pulmonary infiltrates (HP:0002113)3.47319422
31Lymphopenia (HP:0001888)3.39486475
32Obstructive lung disease (HP:0006536)3.34625531
33Chronic obstructive pulmonary disease (HP:0006510)3.34625531
34Recurrent sinusitis (HP:0011108)3.31313551
35Hypergammaglobulinemia (HP:0010702)3.30576937
36Interstitial pulmonary disease (HP:0006530)3.26070952
37Arterial thrombosis (HP:0004420)3.22048327
38Gastrointestinal infarctions (HP:0005244)3.21921969
39Keratoconjunctivitis sicca (HP:0001097)3.15242790
40Periodontitis (HP:0000704)3.13751865
41Hypertensive crisis (HP:0100735)2.99059610
42Restrictive lung disease (HP:0002091)2.96261686
43Nasal polyposis (HP:0100582)2.87553476
44Tetraparesis (HP:0002273)2.87255497
45Cellulitis (HP:0100658)2.83673828
46Meningitis (HP:0001287)2.82937122
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.82209596
48B lymphocytopenia (HP:0010976)2.80170618
49Leukocytosis (HP:0001974)2.78064024
50IgM deficiency (HP:0002850)2.74920336
51Abnormality of B cell number (HP:0010975)2.74913220
52Amaurosis fugax (HP:0100576)2.73090275
53Eosinophilia (HP:0001880)2.70181027
54Loss of speech (HP:0002371)2.69490164
55Hemoptysis (HP:0002105)2.68875650
56Urticaria (HP:0001025)2.68731540
57Vertebral compression fractures (HP:0002953)2.64882443
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.64032188
59Osteolytic defects of the hand bones (HP:0009699)2.64032188
60Peritonitis (HP:0002586)2.61590078
61Vacuolated lymphocytes (HP:0001922)2.57920990
62Myocardial infarction (HP:0001658)2.54281181
63Porencephaly (HP:0002132)2.53582020
64Abnormality of T cell number (HP:0011839)2.52738512
65Pustule (HP:0200039)2.51499617
66Recurrent pneumonia (HP:0006532)2.51364217
67Axonal loss (HP:0003447)2.49738123
68Gingival bleeding (HP:0000225)2.49375650
69Dysostosis multiplex (HP:0000943)2.47705539
70Joint swelling (HP:0001386)2.39703075
71Thick nail (HP:0001805)2.39534060
72Increased cerebral lipofuscin (HP:0011813)2.38308113
73Abnormality of the nasal mucosa (HP:0000433)2.37299834
74Recurrent lower respiratory tract infections (HP:0002783)2.37136973
75Encephalitis (HP:0002383)2.35846192
76Abnormality of the endocardium (HP:0004306)2.33325608
77Abnormality of the pericardium (HP:0001697)2.32575509
78Prostate neoplasm (HP:0100787)2.30890495
79Recurrent bronchitis (HP:0002837)2.30642513
80Lymphoma (HP:0002665)2.30631919
81Colitis (HP:0002583)2.30270646
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.29836683
83Osteomyelitis (HP:0002754)2.26276162
84Granulocytopenia (HP:0001913)2.26266565
85Increased IgE level (HP:0003212)2.24850865
86Anorexia (HP:0002039)2.23933810
87Agammaglobulinemia (HP:0004432)2.23763481
88Hematochezia (HP:0002573)2.23306237
89Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.21259058
90Inflammation of the large intestine (HP:0002037)2.19985390
91Polyneuropathy (HP:0001271)2.19898731
92Increased serum ferritin (HP:0003281)2.15892042
93IgA deficiency (HP:0002720)2.13885696
94Fatigue (HP:0012378)2.09890612
95Abnormality of eosinophils (HP:0001879)2.09656481
96Arthralgia (HP:0002829)2.09616943
97Xerostomia (HP:0000217)2.09441198
98Poor head control (HP:0002421)2.08994688
99Gangrene (HP:0100758)2.07250519
100Thoracolumbar scoliosis (HP:0002944)2.07219810
101Petechiae (HP:0000967)2.04971480
102Skin ulcer (HP:0200042)2.04510043
103Abnormality of the prostate (HP:0008775)2.02654230
104Gastrointestinal inflammation (HP:0004386)2.02269246
105Abnormality of T cell physiology (HP:0011840)2.01834879
106Premature loss of primary teeth (HP:0006323)2.00428112
107Leukopenia (HP:0001882)2.00407610
108Emphysema (HP:0002097)2.00100424
109Abnormality of the pleura (HP:0002103)1.99894262
110Hydroxyprolinuria (HP:0003080)1.99822747
111Abnormality of proline metabolism (HP:0010907)1.99822747
112Abnormality of T cells (HP:0002843)1.98935605
113Memory impairment (HP:0002354)1.96851589
114Parakeratosis (HP:0001036)1.95901155
115Pulmonary embolism (HP:0002204)1.95563992
116T lymphocytopenia (HP:0005403)1.93821892
117Skin rash (HP:0000988)1.93271092
118Chronic sinusitis (HP:0011109)1.92645397
119Disinhibition (HP:0000734)1.89689585
120IgG deficiency (HP:0004315)1.89320638
121Chest pain (HP:0100749)1.87473247
122Autoimmune hemolytic anemia (HP:0001890)1.86680728
123Panhypogammaglobulinemia (HP:0003139)1.86680053
124Abnormality of cells of the lymphoid lineage (HP:0012140)1.84100420
125Keratitis (HP:0000491)1.83451012
126Progressive visual loss (HP:0000529)1.80408570
127Chronic diarrhea (HP:0002028)1.79057937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.19578860
2TBK13.92802669
3IKBKB3.56805731
4TYK23.56638865
5PRPF4B3.37225916
6JAK33.36713425
7BLK2.92580714
8IRAK42.90805288
9IKBKE2.74715315
10MAP3K132.71587930
11RIPK42.61496677
12IRAK32.54403462
13CHUK2.47192949
14MAP4K12.44969618
15JAK12.40363214
16TXK2.10387825
17EPHB11.95472018
18PIM21.94306863
19TAOK21.88499714
20KIT1.65881357
21CDC42BPA1.47610628
22CSK1.46968994
23BMPR21.43698319
24SYK1.41870772
25BMX1.40626846
26CSF1R1.40016012
27PBK1.36353284
28FGR1.32346988
29PIM11.30886913
30EPHA31.29066884
31EIF2AK21.27713762
32TRPM71.23791888
33FGFR41.21340293
34EIF2AK31.19524503
35BTK1.18624088
36HCK1.18118221
37ZAP701.12855804
38ERN11.09729496
39JAK21.08392581
40NEK91.05227488
41MST41.04541097
42LCK1.03824986
43STK241.02225458
44FGFR31.00355020
45STK100.96369402
46PTK60.95530519
47CDK120.91947401
48TEC0.87467371
49LYN0.87046705
50MOS0.87015838
51TESK10.83604102
52ABL20.83206674
53TYRO30.81457516
54MAPK110.81440004
55TTN0.78558574
56RPS6KA40.75767425
57PRKCD0.74371116
58STK40.71172244
59ITK0.70457320
60IRAK20.69169251
61MATK0.67978407
62LRRK20.67189640
63MAPKAPK20.66636097
64ABL10.66284459
65FES0.64957253
66SMG10.64675723
67IRAK10.63501488
68PRKCQ0.62660923
69ADRBK20.62204184
70CCNB10.62061778
71ERBB30.61915932
72PKN10.61907562
73TLK10.61701163
74STK30.61233411
75MAP3K110.60651773
76NUAK10.60086605
77MAP3K100.58206276
78EGFR0.55837114
79HIPK20.54547631
80CDK40.54514999
81MELK0.52988121
82MARK30.52510919
83MAPK40.51842636
84FLT30.50778774
85YES10.50589375
86MAP3K10.49774393
87TGFBR20.49711095
88MAP3K90.49020055
89PDK10.48299567
90GRK70.46599209
91ACVR1B0.46590454
92TAOK30.44738927
93SIK30.43589027
94MAP3K50.41826279
95GRK60.40152556
96DMPK0.40100893
97CDK60.39465208
98TAOK10.39464423
99NLK0.37938845
100BCR0.36817088
101MAPK70.36444673
102ARAF0.36421435
103RPS6KA10.36292947
104MAP3K80.34000744
105INSR0.33772000
106NME20.31246989
107DAPK20.29738124
108DAPK30.28260035
109RPS6KA50.26997993
110RIPK10.26317406
111ALK0.26107011
112SIK20.25199226
113SCYL20.24789036
114MAPKAPK50.24501606
115DYRK1B0.24105441
116PDPK10.23554634
117MAP2K30.22103162
118MAP3K30.20315570
119DDR20.19070489
120SRC0.18371548
121GSK3A0.18017154
122PAK40.17992044
123EEF2K0.17961232
124MAPK30.17043047
125PRKAA20.16896510
126BMPR1B0.16560389
127SGK10.16490057
128IGF1R0.16324964
129CLK10.15557342
130MAP2K60.15517140
131PASK0.14990980
132PDGFRA0.14678614
133AKT10.14447270

Predicted pathways (KEGG)

RankGene SetZ-score
1* Graft-versus-host disease_Homo sapiens_hsa053323.44364288
2Leishmaniasis_Homo sapiens_hsa051403.22254954
3* Allograft rejection_Homo sapiens_hsa053303.20229814
4NF-kappa B signaling pathway_Homo sapiens_hsa040643.06694457
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.74848338
6* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.72330163
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.55664424
8Legionellosis_Homo sapiens_hsa051342.55429988
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.44012463
10Measles_Homo sapiens_hsa051622.36610017
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.36591850
12* Intestinal immune network for IgA production_Homo sapiens_hsa046722.36547672
13Osteoclast differentiation_Homo sapiens_hsa043802.20211869
14TNF signaling pathway_Homo sapiens_hsa046682.17637534
15Malaria_Homo sapiens_hsa051442.17180232
16* Type I diabetes mellitus_Homo sapiens_hsa049402.14227315
17Staphylococcus aureus infection_Homo sapiens_hsa051502.12654969
18Pertussis_Homo sapiens_hsa051332.08584969
19* Rheumatoid arthritis_Homo sapiens_hsa053232.06550561
20Tuberculosis_Homo sapiens_hsa051522.04727766
21Asthma_Homo sapiens_hsa053101.82066551
22Influenza A_Homo sapiens_hsa051641.80752641
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.79545539
24* Autoimmune thyroid disease_Homo sapiens_hsa053201.73639766
25Herpes simplex infection_Homo sapiens_hsa051681.71831450
26Salmonella infection_Homo sapiens_hsa051321.70861945
27Toxoplasmosis_Homo sapiens_hsa051451.70372455
28African trypanosomiasis_Homo sapiens_hsa051431.67311890
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.60774469
30Chemokine signaling pathway_Homo sapiens_hsa040621.58796842
31Primary immunodeficiency_Homo sapiens_hsa053401.56687045
32B cell receptor signaling pathway_Homo sapiens_hsa046621.49912522
33Apoptosis_Homo sapiens_hsa042101.48213465
34Shigellosis_Homo sapiens_hsa051311.47680783
35Antigen processing and presentation_Homo sapiens_hsa046121.46379297
36* Systemic lupus erythematosus_Homo sapiens_hsa053221.45917198
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45902850
38Hematopoietic cell lineage_Homo sapiens_hsa046401.39588917
39* Viral myocarditis_Homo sapiens_hsa054161.35341205
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28707255
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27956356
42Hepatitis B_Homo sapiens_hsa051611.22621769
43Phagosome_Homo sapiens_hsa041451.20524152
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07770274
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07116270
46Amoebiasis_Homo sapiens_hsa051461.03213769
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02153527
48T cell receptor signaling pathway_Homo sapiens_hsa046600.99647319
49Hepatitis C_Homo sapiens_hsa051600.98661864
50Lysosome_Homo sapiens_hsa041420.89371782
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.88014992
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84037865
53Acute myeloid leukemia_Homo sapiens_hsa052210.82280070
54Small cell lung cancer_Homo sapiens_hsa052220.79150558
55Chronic myeloid leukemia_Homo sapiens_hsa052200.76808390
56Epstein-Barr virus infection_Homo sapiens_hsa051690.74909635
57Prolactin signaling pathway_Homo sapiens_hsa049170.73724232
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72698708
59p53 signaling pathway_Homo sapiens_hsa041150.69566934
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67249698
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64723380
62Prion diseases_Homo sapiens_hsa050200.64461107
63Pancreatic cancer_Homo sapiens_hsa052120.60957676
64Viral carcinogenesis_Homo sapiens_hsa052030.60712258
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.56836616
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.53725444
67HTLV-I infection_Homo sapiens_hsa051660.48110351
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46641771
69Other glycan degradation_Homo sapiens_hsa005110.46101875
70Bladder cancer_Homo sapiens_hsa052190.44743415
71Proteoglycans in cancer_Homo sapiens_hsa052050.44438551
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44322391
73Platelet activation_Homo sapiens_hsa046110.44079855
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43738984
75MicroRNAs in cancer_Homo sapiens_hsa052060.42837052
76HIF-1 signaling pathway_Homo sapiens_hsa040660.38188797
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.37781442
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37106082
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35607378
80Tryptophan metabolism_Homo sapiens_hsa003800.35319612
81Complement and coagulation cascades_Homo sapiens_hsa046100.33104104
82MAPK signaling pathway_Homo sapiens_hsa040100.29972337
83* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29514318
84Dorso-ventral axis formation_Homo sapiens_hsa043200.28021989
85Notch signaling pathway_Homo sapiens_hsa043300.26894799
86VEGF signaling pathway_Homo sapiens_hsa043700.26108650
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25200715
88FoxO signaling pathway_Homo sapiens_hsa040680.22758829
89Endocytosis_Homo sapiens_hsa041440.21313577
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21065345
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.20519814
92Type II diabetes mellitus_Homo sapiens_hsa049300.20475060
93Focal adhesion_Homo sapiens_hsa045100.20226536
94Adherens junction_Homo sapiens_hsa045200.20218114
95Sphingolipid metabolism_Homo sapiens_hsa006000.17493281
96Insulin resistance_Homo sapiens_hsa049310.17157377
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16719322
98Pathways in cancer_Homo sapiens_hsa052000.14806497
99Inositol phosphate metabolism_Homo sapiens_hsa005620.12911046
100Prostate cancer_Homo sapiens_hsa052150.11990962
101Alcoholism_Homo sapiens_hsa050340.10964077
102Fructose and mannose metabolism_Homo sapiens_hsa000510.07012222
103Non-small cell lung cancer_Homo sapiens_hsa052230.03742972
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.03461878
105Ras signaling pathway_Homo sapiens_hsa040140.03309673
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.03307929
107Sulfur metabolism_Homo sapiens_hsa009200.02955337
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.02484673
109Renal cell carcinoma_Homo sapiens_hsa052110.02478285
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01388278
111GnRH signaling pathway_Homo sapiens_hsa049120.00918422
112Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0612302
113Collecting duct acid secretion_Homo sapiens_hsa04966-0.0492953
114mTOR signaling pathway_Homo sapiens_hsa04150-0.0066798

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