CD83

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)5.86782809
2NIK/NF-kappaB signaling (GO:0038061)5.62378039
3regulation of dendritic cell antigen processing and presentation (GO:0002604)5.45428273
4antigen processing and presentation of endogenous antigen (GO:0019883)5.44144387
5regulation of vitamin D biosynthetic process (GO:0060556)5.05249027
6positive regulation of antigen processing and presentation (GO:0002579)5.05079865
7regulation of interleukin-12 biosynthetic process (GO:0045075)5.04858586
8negative regulation of interleukin-12 production (GO:0032695)4.69794945
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.65631486
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.60361852
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.60361852
12modulation by symbiont of host immune response (GO:0052553)4.60361852
13positive regulation by symbiont of host defense response (GO:0052509)4.60361852
14modulation by symbiont of host defense response (GO:0052031)4.60361852
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.60361852
16positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.59957849
17response to muramyl dipeptide (GO:0032495)4.59658212
18regulation of chronic inflammatory response (GO:0002676)4.52545328
19regulation of B cell receptor signaling pathway (GO:0050855)4.50524156
20neutrophil activation involved in immune response (GO:0002283)4.49174499
21positive regulation of T-helper cell differentiation (GO:0045624)4.40471985
22regulation of antigen processing and presentation (GO:0002577)4.35310003
23myeloid dendritic cell differentiation (GO:0043011)4.32588076
24positive regulation of interleukin-12 production (GO:0032735)4.32019341
25regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.24986560
26microglial cell activation (GO:0001774)4.12828397
27immunoglobulin mediated immune response (GO:0016064)4.11366114
28regulation of T-helper cell differentiation (GO:0045622)4.06487673
29macrophage activation involved in immune response (GO:0002281)4.02349493
30myeloid dendritic cell activation (GO:0001773)4.01863986
31positive regulation of gamma-delta T cell activation (GO:0046645)3.98881111
32regulation of vitamin metabolic process (GO:0030656)3.94431687
33response to peptidoglycan (GO:0032494)3.92627475
34neutrophil activation (GO:0042119)3.83760560
35positive regulation of B cell differentiation (GO:0045579)3.83051831
36positive regulation of chemokine biosynthetic process (GO:0045080)3.81327656
37response to protozoan (GO:0001562)3.77408939
38B cell receptor signaling pathway (GO:0050853)3.77145687
39negative thymic T cell selection (GO:0045060)3.76101647
40positive regulation of interferon-alpha production (GO:0032727)3.73143063
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.73060293
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73060293
43regulation of T cell tolerance induction (GO:0002664)3.72593716
44regulation of interferon-beta biosynthetic process (GO:0045357)3.71149771
45mature B cell differentiation (GO:0002335)3.70158520
46positive regulation of NF-kappaB import into nucleus (GO:0042346)3.68043059
47interferon-gamma-mediated signaling pathway (GO:0060333)3.66071505
48granulocyte activation (GO:0036230)3.66026802
49positive regulation of heat generation (GO:0031652)3.65302919
50eosinophil chemotaxis (GO:0048245)3.63574288
51positive regulation of T-helper 1 type immune response (GO:0002827)3.63006917
52regulation of podosome assembly (GO:0071801)3.61332123
53regulation of fever generation (GO:0031620)3.60725893
54regulation of interferon-alpha production (GO:0032647)3.58787212
55dendritic cell differentiation (GO:0097028)3.57818318
56positive regulation of macrophage cytokine production (GO:0060907)3.57557500
57* regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.54977190
58regulation of interleukin-12 production (GO:0032655)3.54313122
59germinal center formation (GO:0002467)3.53837047
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.50362843
61natural killer cell mediated cytotoxicity (GO:0042267)3.48585593
62natural killer cell mediated immunity (GO:0002228)3.48585593
63negative T cell selection (GO:0043383)3.45312937
64positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.43739894
65positive regulation of type 2 immune response (GO:0002830)3.41640172
66regulation of cytokine secretion involved in immune response (GO:0002739)3.40892077
67* positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.39862541
68regulation of chemokine biosynthetic process (GO:0045073)3.36208090
69positive thymic T cell selection (GO:0045059)3.35622642
70regulation of B cell differentiation (GO:0045577)3.33639039
71positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.32945056
72cellular extravasation (GO:0045123)3.32708135
73positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.31031264
74regulation of T-helper 1 type immune response (GO:0002825)3.30828180
75myeloid cell activation involved in immune response (GO:0002275)3.29273623
76negative regulation of cell killing (GO:0031342)3.28364397
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.28364397
78regulation of mononuclear cell migration (GO:0071675)3.27439890
79regulation of interferon-gamma biosynthetic process (GO:0045072)3.26877098
80regulation of interleukin-8 biosynthetic process (GO:0045414)3.22132057
81positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.21972909
82cellular response to zinc ion (GO:0071294)3.20904621
83cellular response to interferon-gamma (GO:0071346)3.20341796
84CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.20005844
85T-helper cell differentiation (GO:0042093)3.20005844
86lipopolysaccharide-mediated signaling pathway (GO:0031663)3.17961520
87respiratory burst (GO:0045730)3.17913784
88JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.17407080
89eosinophil migration (GO:0072677)3.17167369
90positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16845196
91negative regulation of granulocyte differentiation (GO:0030853)3.16171927
92positive regulation of neutrophil chemotaxis (GO:0090023)3.14275136
93positive regulation of neutrophil migration (GO:1902624)3.14275136
94positive regulation of alpha-beta T cell proliferation (GO:0046641)3.13613110
95regulation of inflammatory response to antigenic stimulus (GO:0002861)3.11691408
96* regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.10777944
97regulation of alpha-beta T cell proliferation (GO:0046640)3.09529248
98positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.08557782
99regulation of interleukin-2 biosynthetic process (GO:0045076)3.07558313
100B cell mediated immunity (GO:0019724)3.07550236
101negative regulation of interleukin-17 production (GO:0032700)3.07067278
102regulation of interleukin-1 beta secretion (GO:0050706)3.06411396
103production of molecular mediator involved in inflammatory response (GO:0002532)3.06358139
104T cell migration (GO:0072678)3.06313193
105cellular response to lipopolysaccharide (GO:0071222)3.05887263
106macrophage activation (GO:0042116)3.05757632
107B cell homeostasis (GO:0001782)3.05518929
108myeloid leukocyte activation (GO:0002274)3.04979978
109G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.03647061
110negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.02344588
111regulation of type 2 immune response (GO:0002828)3.02318632
112regulation of activation of Janus kinase activity (GO:0010533)3.01803382
113regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.01530653
114negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.00960115
115positive regulation of interleukin-17 production (GO:0032740)3.00327596
116response to interferon-gamma (GO:0034341)2.99919740
117monocyte chemotaxis (GO:0002548)2.99659995
118negative regulation of cytokine production involved in immune response (GO:0002719)2.99233337
119cellular response to molecule of bacterial origin (GO:0071219)2.97840568
120regulation of NF-kappaB import into nucleus (GO:0042345)2.97450497
121positive regulation of interleukin-1 beta secretion (GO:0050718)2.97000719
122positive regulation of humoral immune response (GO:0002922)2.96782143
123type I interferon signaling pathway (GO:0060337)2.95786762
124cellular response to type I interferon (GO:0071357)2.95786762
125cytokine secretion (GO:0050663)2.95362872
126negative regulation of interleukin-10 production (GO:0032693)2.94924864
127response to type I interferon (GO:0034340)2.92218032
128negative regulation of growth of symbiont in host (GO:0044130)2.92065597
129negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.92065597
130modulation of growth of symbiont involved in interaction with host (GO:0044144)2.92065597
131regulation of growth of symbiont in host (GO:0044126)2.92065597
132positive regulation of granulocyte chemotaxis (GO:0071624)2.91998934
133* positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.91652340
134T cell activation involved in immune response (GO:0002286)2.88667763
135regulation of B cell proliferation (GO:0030888)2.88022508
136positive regulation of cytokine biosynthetic process (GO:0042108)2.87157950
137lymphocyte chemotaxis (GO:0048247)2.86752197
138positive regulation of B cell proliferation (GO:0030890)2.86312058
139negative regulation of B cell proliferation (GO:0030889)2.86254064
140regulation of tolerance induction (GO:0002643)2.86091549
141defense response to protozoan (GO:0042832)2.85486665
142T-helper 1 type immune response (GO:0042088)2.85367018
143regulation of T-helper 2 cell differentiation (GO:0045628)2.83704503
144positive regulation of defense response to virus by host (GO:0002230)2.83637277
145adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.83635812
146regulation of RIG-I signaling pathway (GO:0039535)2.83615199
147mature B cell differentiation involved in immune response (GO:0002313)2.83286196
148response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83028266
149response to host immune response (GO:0052572)2.83028266
150leukocyte mediated cytotoxicity (GO:0001909)2.82971372
151dendritic cell chemotaxis (GO:0002407)2.82952989
152lymphocyte mediated immunity (GO:0002449)2.82448833
153* positive regulation of interleukin-2 production (GO:0032743)2.82134195
154positive regulation of interferon-beta production (GO:0032728)2.81805245
155regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.81144424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.89534357
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.90048740
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.79540478
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.50659586
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.37478976
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.10707353
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.99732821
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.84983264
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.57189691
10* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.42178654
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.36773020
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.29552912
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.19227394
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.15079976
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13073505
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.10029639
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.91310209
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.60845603
19* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53447615
20* RUNX_20019798_ChIP-Seq_JUKART_Human2.52758789
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50052601
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29321925
23* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25644396
24MYB_26560356_Chip-Seq_TH2_Human2.18686691
25MAF_26560356_Chip-Seq_TH1_Human2.06630262
26VDR_24763502_ChIP-Seq_THP-1_Human2.03076727
27SPI1_23547873_ChIP-Seq_NB4_Human1.96694561
28VDR_24787735_ChIP-Seq_THP-1_Human1.95633873
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89589628
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87549332
31PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.86901509
32VDR_21846776_ChIP-Seq_THP-1_Human1.86533940
33SPI1_23127762_ChIP-Seq_K562_Human1.86441295
34MYB_26560356_Chip-Seq_TH1_Human1.77315440
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.73879801
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.73334221
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72457207
38PU_27001747_Chip-Seq_BMDM_Mouse1.72182697
39NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.62445026
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.56511609
41* SCL_19346495_ChIP-Seq_HPC-7_Human1.54744045
42MYC_22102868_ChIP-Seq_BL_Human1.53154879
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.48457514
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.48385517
45TCF7_22412390_ChIP-Seq_EML_Mouse1.47821177
46GATA3_27048872_Chip-Seq_THYMUS_Human1.44884188
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35866656
48GATA3_26560356_Chip-Seq_TH2_Human1.34731603
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33750471
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30883483
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29539165
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27212197
53GATA1_22025678_ChIP-Seq_K562_Human1.22133840
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.19895824
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19052396
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18422701
57UTX_26944678_Chip-Seq_JUKART_Human1.18116157
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16663934
59EGR1_19032775_ChIP-ChIP_M12_Human1.15227462
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15068768
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14160282
62KDM2B_26808549_Chip-Seq_DND41_Human1.11817525
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11633642
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11361420
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10729582
66MAF_26560356_Chip-Seq_TH2_Human1.08656978
67TFEB_21752829_ChIP-Seq_HELA_Human1.08388649
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06571126
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04599838
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03156776
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02470513
72* SMRT_27268052_Chip-Seq_Bcells_Human1.00796461
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99729062
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99463474
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95273611
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95236538
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94418622
78STAT1_20625510_ChIP-Seq_HELA_Human0.92866007
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92293479
80ELK3_25401928_ChIP-Seq_HUVEC_Human0.91097796
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89311038
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88809956
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88452636
84STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87322569
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.86202630
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84184839
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79961719
88FOXO3_23340844_ChIP-Seq_DLD1_Human0.79945081
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79708153
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79645465
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78996194
92ESR2_21235772_ChIP-Seq_MCF-7_Human0.76366215
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73025015
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.72511885
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72480926
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.72065068
97* GATA2_19941826_ChIP-Seq_K562_Human0.71546132
98CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69792977
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.68527640
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.68390872
101LXR_22292898_ChIP-Seq_THP-1_Human0.67981958
102ESR1_21235772_ChIP-Seq_MCF-7_Human0.67624086
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.67522349
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.67522349
105WT1_19549856_ChIP-ChIP_CCG9911_Human0.67195525
106SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.65690845
107* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65636986
108NCOR1_26117541_ChIP-Seq_K562_Human0.63848463
109JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63599886
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61965431
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.61286140
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60839049
113* GATA1_19941826_ChIP-Seq_K562_Human0.59987152
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.57711837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.42941250
2MP0004510_myositis3.69550872
3MP0001790_abnormal_immune_system3.61262502
4MP0005387_immune_system_phenotype3.61262502
5MP0000685_abnormal_immune_system3.59671989
6MP0003303_peritoneal_inflammation3.46306245
7MP0003436_decreased_susceptibility_to3.39136223
8MP0005671_abnormal_response_to3.33048573
9* MP0002148_abnormal_hypersensitivity_rea3.27744478
10* MP0001800_abnormal_humoral_immune3.26251800
11MP0005000_abnormal_immune_tolerance3.26204910
12MP0002254_reproductive_system_inflammat3.11776648
13MP0002138_abnormal_hepatobiliary_system3.02121241
14* MP0002452_abnormal_antigen_presenting2.97367668
15MP0009785_altered_susceptibility_to2.86843784
16MP0002419_abnormal_innate_immunity2.77573154
17* MP0002723_abnormal_immune_serum2.75369915
18MP0005025_abnormal_response_to2.50520689
19* MP0001819_abnormal_immune_cell2.49230218
20* MP0002420_abnormal_adaptive_immunity2.47953558
21MP0001853_heart_inflammation2.34096498
22MP0005310_abnormal_salivary_gland2.26440830
23MP0002166_altered_tumor_susceptibility2.13752746
24MP0006082_CNS_inflammation2.05663541
25MP0005058_abnormal_lysosome_morphology2.05098482
26MP0002139_abnormal_hepatobiliary_system2.01206203
27MP0002405_respiratory_system_inflammati1.98880918
28MP0000569_abnormal_digit_pigmentation1.88242959
29* MP0000716_abnormal_immune_system1.88187169
30* MP0002398_abnormal_bone_marrow1.85421344
31MP0005451_abnormal_body_composition1.84786963
32MP0005464_abnormal_platelet_physiology1.79361569
33MP0002006_tumorigenesis1.77329548
34MP0003300_gastrointestinal_ulcer1.74356003
35MP0001348_abnormal_lacrimal_gland1.73739819
36MP0001845_abnormal_inflammatory_respons1.72227546
37MP0004947_skin_inflammation1.67715969
38MP0010155_abnormal_intestine_physiology1.63584041
39MP0002277_abnormal_respiratory_mucosa1.60891268
40MP0003191_abnormal_cellular_cholesterol1.60714451
41MP0003195_calcinosis1.60296429
42MP0000689_abnormal_spleen_morphology1.56580062
43MP0001533_abnormal_skeleton_physiology1.52885377
44MP0003724_increased_susceptibility_to1.47966531
45MP0008004_abnormal_stomach_pH1.47434149
46* MP0002429_abnormal_blood_cell1.47096719
47MP0002722_abnormal_immune_system1.44631965
48MP0003172_abnormal_lysosome_physiology1.43391748
49MP0002163_abnormal_gland_morphology1.39246950
50MP0001873_stomach_inflammation1.37687185
51MP0003448_altered_tumor_morphology1.36998272
52MP0008469_abnormal_protein_level1.36864681
53MP0009764_decreased_sensitivity_to1.35550355
54MP0003763_abnormal_thymus_physiology1.35497263
55MP0008057_abnormal_DNA_replication1.30214768
56MP0005076_abnormal_cell_differentiation1.29348176
57MP0009840_abnormal_foam_cell1.23767258
58MP0000604_amyloidosis1.23333955
59MP0003183_abnormal_peptide_metabolism1.22776597
60MP0009333_abnormal_splenocyte_physiolog1.13460803
61MP0003075_altered_response_to1.12261938
62MP0009278_abnormal_bone_marrow1.06019093
63MP0002332_abnormal_exercise_endurance1.05216941
64MP0003656_abnormal_erythrocyte_physiolo1.03972605
65MP0001545_abnormal_hematopoietic_system1.03563815
66MP0005397_hematopoietic_system_phenotyp1.03563815
67MP0003806_abnormal_nucleotide_metabolis1.02714366
68MP0003828_pulmonary_edema1.01484894
69MP0002009_preneoplasia1.00673718
70MP0003091_abnormal_cell_migration1.00334450
71MP0002877_abnormal_melanocyte_morpholog1.00141732
72MP0000703_abnormal_thymus_morphology0.99845859
73MP0002933_joint_inflammation0.99412173
74MP0002998_abnormal_bone_remodeling0.97063752
75MP0000858_altered_metastatic_potential0.96540324
76MP0000343_altered_response_to0.92616058
77MP0003453_abnormal_keratinocyte_physiol0.85910021
78MP0005647_abnormal_sex_gland0.83918033
79MP0009765_abnormal_xenobiotic_induced0.83328127
80MP0001851_eye_inflammation0.82177413
81MP0005174_abnormal_tail_pigmentation0.81052754
82MP0010352_gastrointestinal_tract_polyps0.80885353
83MP0003866_abnormal_defecation0.80516644
84MP0000249_abnormal_blood_vessel0.77933378
85MP0004808_abnormal_hematopoietic_stem0.77252133
86MP0003690_abnormal_glial_cell0.76873823
87MP0000465_gastrointestinal_hemorrhage0.76711792
88MP0000920_abnormal_myelination0.75130300
89MP0009763_increased_sensitivity_to0.74672831
90MP0001501_abnormal_sleep_pattern0.74516906
91MP0000371_diluted_coat_color0.72657758
92MP0003045_fibrosis0.71959220
93MP0010307_abnormal_tumor_latency0.71787030
94MP0005167_abnormal_blood-brain_barrier0.71757497
95MP0006054_spinal_hemorrhage0.71021642
96MP0005379_endocrine/exocrine_gland_phen0.70565664
97MP0002396_abnormal_hematopoietic_system0.70138958
98MP0002136_abnormal_kidney_physiology0.69171848
99MP0005165_increased_susceptibility_to0.68672392
100MP0000767_abnormal_smooth_muscle0.68271232
101MP0002928_abnormal_bile_duct0.67736018
102MP0005390_skeleton_phenotype0.66899507
103MP0005166_decreased_susceptibility_to0.66823849
104MP0008874_decreased_physiological_sensi0.66103686
105MP0003566_abnormal_cell_adhesion0.63274748
106MP0008260_abnormal_autophagy0.60968518
107MP0001346_abnormal_lacrimal_gland0.60309675
108MP0005164_abnormal_response_to0.58913428
109MP0003329_amyloid_beta_deposits0.57345497
110MP0004883_abnormal_blood_vessel0.55205729
111MP0003646_muscle_fatigue0.53877228
112MP0004742_abnormal_vestibular_system0.52259370
113MP0000490_abnormal_crypts_of0.52238925
114MP0002693_abnormal_pancreas_physiology0.51325160
115MP0000609_abnormal_liver_physiology0.49136647
116MP0001879_abnormal_lymphatic_vessel0.48598257
117MP0003795_abnormal_bone_structure0.42857149
118MP0001663_abnormal_digestive_system0.42757376
119MP0001191_abnormal_skin_condition0.42741741

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.28934048
2Recurrent bacterial skin infections (HP:0005406)6.07042885
3Eczematoid dermatitis (HP:0000976)5.55255460
4Systemic lupus erythematosus (HP:0002725)5.48054503
5Optic neuritis (HP:0100653)4.32929741
6Retrobulbar optic neuritis (HP:0100654)4.32929741
7Mediastinal lymphadenopathy (HP:0100721)4.29193711
8Colitis (HP:0002583)4.22151042
9Orchitis (HP:0100796)4.11489577
10Glomerulonephritis (HP:0000099)4.08705797
11Recurrent fungal infections (HP:0002841)4.07970934
12Myositis (HP:0100614)4.06261497
13Agammaglobulinemia (HP:0004432)4.05354414
14Recurrent viral infections (HP:0004429)4.01231694
15Recurrent skin infections (HP:0001581)3.98541464
16Elevated erythrocyte sedimentation rate (HP:0003565)3.93748703
17Loss of speech (HP:0002371)3.93386830
18Vasculitis (HP:0002633)3.85971515
19Recurrent gram-negative bacterial infections (HP:0005420)3.82167743
20Cellulitis (HP:0100658)3.80723226
21Pulmonary infiltrates (HP:0002113)3.79106586
22Abnormality of macrophages (HP:0004311)3.74451654
23Vacuolated lymphocytes (HP:0001922)3.62611081
24Chronic otitis media (HP:0000389)3.55512149
25Mutism (HP:0002300)3.55194128
26Increased cerebral lipofuscin (HP:0011813)3.51071168
27Hematochezia (HP:0002573)3.49202578
28Increased neuronal autofluorescent lipopigment (HP:0002074)3.44084051
29Myocardial infarction (HP:0001658)3.41990019
30Inflammation of the large intestine (HP:0002037)3.35054976
31Gastrointestinal stroma tumor (HP:0100723)3.33304853
32Chronic mucocutaneous candidiasis (HP:0002728)3.21831039
33Recurrent cutaneous fungal infections (HP:0011370)3.21831039
34Stomatitis (HP:0010280)3.17914016
35Autoimmune thrombocytopenia (HP:0001973)3.13922699
36Gingivitis (HP:0000230)3.12488865
37Meningitis (HP:0001287)3.10149468
38Arterial thrombosis (HP:0004420)3.07366840
39Gastrointestinal inflammation (HP:0004386)3.07165149
40Recurrent bronchitis (HP:0002837)3.06216485
41Gastrointestinal infarctions (HP:0005244)3.06200987
42Abnormal delayed hypersensitivity skin test (HP:0002963)3.05189398
43Gangrene (HP:0100758)3.03793157
44Chronic obstructive pulmonary disease (HP:0006510)2.99641842
45Obstructive lung disease (HP:0006536)2.99641842
46Increased IgM level (HP:0003496)2.91211937
47Panhypogammaglobulinemia (HP:0003139)2.90470490
48Recurrent pneumonia (HP:0006532)2.85546285
49Leukocytosis (HP:0001974)2.83591755
50Osteomyelitis (HP:0002754)2.82935057
51Abnormality of liposaccharide metabolism (HP:0010968)2.81248957
52Abnormality of glycosphingolipid metabolism (HP:0004343)2.81248957
53Abnormality of glycolipid metabolism (HP:0010969)2.81248957
54Abnormality of polysaccharide metabolism (HP:0011012)2.78555863
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.78555863
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.78555863
57Basal ganglia calcification (HP:0002135)2.78141785
58Eosinophilia (HP:0001880)2.73580780
59Thyroiditis (HP:0100646)2.72131584
60Periodontitis (HP:0000704)2.71209983
61Spontaneous hematomas (HP:0007420)2.70636605
62Keratoconjunctivitis sicca (HP:0001097)2.68021742
63Urinary glycosaminoglycan excretion (HP:0003541)2.65171424
64Mucopolysacchariduria (HP:0008155)2.65171424
65T lymphocytopenia (HP:0005403)2.64466204
66Recurrent lower respiratory tract infections (HP:0002783)2.63879286
67Complement deficiency (HP:0004431)2.62390109
68Increased serum ferritin (HP:0003281)2.59422692
69Interstitial pulmonary disease (HP:0006530)2.57715893
70Amaurosis fugax (HP:0100576)2.54773316
71Apathy (HP:0000741)2.54303666
72Autoimmune hemolytic anemia (HP:0001890)2.53900494
73Emphysema (HP:0002097)2.52592818
74Nasal polyposis (HP:0100582)2.51628856
75Abnormality of complement system (HP:0005339)2.50144190
76Dysostosis multiplex (HP:0000943)2.49966089
77Diminished motivation (HP:0000745)2.49061846
78Fatigue (HP:0012378)2.48456775
79Polyneuropathy (HP:0001271)2.47445680
80Prostate neoplasm (HP:0100787)2.46208391
81Amyloidosis (HP:0011034)2.45176608
82Keratoconjunctivitis (HP:0001096)2.44954244
83IgM deficiency (HP:0002850)2.41105159
84Pustule (HP:0200039)2.40705846
85Neurofibrillary tangles (HP:0002185)2.39928690
86Osteolytic defects of the hand bones (HP:0009699)2.39345394
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.39345394
88IgA deficiency (HP:0002720)2.38540732
89Chronic diarrhea (HP:0002028)2.37948365
90Increased IgE level (HP:0003212)2.37063366
91Abnormality of cells of the lymphoid lineage (HP:0012140)2.36702933
92Disinhibition (HP:0000734)2.36366635
93Abnormality of T cell number (HP:0011839)2.35178033
94Chronic sinusitis (HP:0011109)2.34702457
95Lymphopenia (HP:0001888)2.34571020
96Thick nail (HP:0001805)2.33704728
97Hypergammaglobulinemia (HP:0010702)2.31858944
98Agnosia (HP:0010524)2.31224467
99Nephritis (HP:0000123)2.30980243
100Abnormality of eosinophils (HP:0001879)2.30493568
101Encephalitis (HP:0002383)2.30364075
102Granulocytopenia (HP:0001913)2.29611448
103Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.29587500
104Hemoptysis (HP:0002105)2.26781419
105Neuronal loss in central nervous system (HP:0002529)2.26676929
106Nuclear cataract (HP:0100018)2.25840225
107Recurrent sinusitis (HP:0011108)2.25791645
108Abnormality of the prostate (HP:0008775)2.24776899
109Axonal loss (HP:0003447)2.23531692
110Anorexia (HP:0002039)2.20449255
111Abnormality of the pleura (HP:0002103)2.16919536
112Gingival bleeding (HP:0000225)2.15639039
113Hypertensive crisis (HP:0100735)2.15209314
114Nausea (HP:0002018)2.14818619
115Thrombocytosis (HP:0001894)2.14281966
116Arthralgia (HP:0002829)2.13891014
117Urticaria (HP:0001025)2.13276013
118Purpura (HP:0000979)2.13251165
119Abnormality of the nasal mucosa (HP:0000433)2.13186502
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11110267
121IgG deficiency (HP:0004315)2.07999115
122Verrucae (HP:0200043)2.07963366
123Papilloma (HP:0012740)2.07963366
124Restrictive lung disease (HP:0002091)2.07340105
125Inappropriate behavior (HP:0000719)2.07127712
126Progressive neurologic deterioration (HP:0002344)2.06418461
127Memory impairment (HP:0002354)2.03749621
128Chest pain (HP:0100749)2.03609554
129B lymphocytopenia (HP:0010976)1.99921941
130Abnormality of B cell number (HP:0010975)1.99685288
131Hepatosplenomegaly (HP:0001433)1.99393575
132Abnormality of the vasculature of the conjunctiva (HP:0008054)1.99268138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.63430933
2TYK23.63743181
3IKBKB3.49532858
4TBK13.40356449
5RIPK43.38315639
6MAP4K13.28492712
7BLK3.01266443
8MAP3K132.86444549
9NME22.75212534
10IRAK32.68014801
11IKBKE2.62396914
12CHUK2.55475695
13IRAK42.54331205
14PRPF4B2.38971542
15JAK12.34599720
16TAOK22.33386117
17MAP3K102.29467260
18JAK32.26402693
19CSF1R2.20366161
20DDR22.16111334
21TGFBR22.02984582
22KIT2.00545672
23EPHB11.79624292
24SYK1.69473025
25ADRBK21.51615612
26ZAP701.48164447
27BTK1.46306947
28CSK1.44954229
29CAMK1D1.44748411
30EPHA31.42164025
31TXK1.40310226
32BMPR21.38006296
33MST41.36530983
34PDK21.31246624
35TAOK31.29140219
36MAPK151.28868191
37HCK1.28338137
38TAOK11.27331303
39GRK61.26392573
40IRAK21.25851621
41CDC42BPA1.22574389
42PIM11.20214646
43ITK1.17299017
44LYN1.16909671
45LCK1.16731749
46JAK21.14570579
47PIM21.13320727
48RIPK11.09603363
49FGFR41.08867699
50STK101.07664328
51MATK1.05657435
52FGFR31.03799578
53MAP2K31.02465228
54NEK91.02460259
55FES0.93679853
56PKN10.93546116
57ERN10.84854691
58GRK70.84537727
59RPS6KA40.78786211
60TEC0.77080049
61SIK20.76512108
62MAPKAPK20.72940390
63LRRK20.71936628
64PRKCQ0.71857437
65FGR0.69117336
66ACVR1B0.67961908
67EIF2AK20.67604610
68TYRO30.66490740
69MAP3K30.63648073
70EIF2AK30.59869938
71PRKCD0.59310057
72CAMK1G0.58592312
73IRAK10.58237558
74MARK30.58202809
75ABL10.58081636
76EGFR0.56649641
77YES10.56001187
78ABL20.52631857
79DAPK20.52233119
80GSK3A0.51544743
81SCYL20.51516872
82SIK30.51124525
83MOS0.49880513
84NLK0.45948875
85MAP3K90.45614555
86FLT30.44667145
87STK240.41963691
88PTK60.41496349
89MAP3K10.40685647
90PDGFRB0.40568554
91CLK10.39963603
92MAP3K50.39469880
93MAP3K110.38606313
94PRKAA20.37106206
95PDPK10.36046195
96RPS6KA50.34414621
97INSR0.34409211
98CDK60.33856444
99CAMKK20.32821701
100RPS6KL10.31586524
101RPS6KC10.31586524
102TNK20.29325361
103SGK10.29154828
104MAP2K20.29080990
105MAPK120.28981958
106FYN0.28399426
107ALK0.27302481
108CDK40.26469697
109TSSK60.25861161
110BMX0.25609815
111ARAF0.25154930
112MAPK70.25152634
113RPS6KA60.25042735
114HIPK20.24907899
115IGF1R0.24756688
116RET0.24567626
117STK40.24382930
118PDK10.24160048
119DYRK1B0.23620838
120TESK20.23269436
121MAP2K60.23146790
122RPS6KA10.22008187
123STK110.21842894
124PRKCZ0.20038464
125MAPK40.18499171
126TRIB30.18361879
127DAPK30.18024534
128MAPK30.17986054
129PDGFRA0.17051400

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040643.12033987
2Leishmaniasis_Homo sapiens_hsa051402.97935896
3B cell receptor signaling pathway_Homo sapiens_hsa046622.94409211
4Osteoclast differentiation_Homo sapiens_hsa043802.82146210
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.60329680
6Allograft rejection_Homo sapiens_hsa053302.54710792
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.52533240
8Staphylococcus aureus infection_Homo sapiens_hsa051502.50023452
9Graft-versus-host disease_Homo sapiens_hsa053322.15044501
10Primary immunodeficiency_Homo sapiens_hsa053402.12498256
11Measles_Homo sapiens_hsa051622.10108710
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.07145650
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04042122
14Antigen processing and presentation_Homo sapiens_hsa046122.00796444
15Pertussis_Homo sapiens_hsa051331.99773755
16Toxoplasmosis_Homo sapiens_hsa051451.96126034
17TNF signaling pathway_Homo sapiens_hsa046681.92823812
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88749189
19Tuberculosis_Homo sapiens_hsa051521.82973952
20Legionellosis_Homo sapiens_hsa051341.82003389
21Chemokine signaling pathway_Homo sapiens_hsa040621.81248949
22Apoptosis_Homo sapiens_hsa042101.70093041
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68060622
24Influenza A_Homo sapiens_hsa051641.65922326
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65440298
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.62860003
27T cell receptor signaling pathway_Homo sapiens_hsa046601.54386085
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50763023
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.49126526
30Shigellosis_Homo sapiens_hsa051311.48127842
31Type I diabetes mellitus_Homo sapiens_hsa049401.44346013
32Autoimmune thyroid disease_Homo sapiens_hsa053201.43045952
33Malaria_Homo sapiens_hsa051441.42868057
34Lysosome_Homo sapiens_hsa041421.41782117
35Herpes simplex infection_Homo sapiens_hsa051681.39878264
36Rheumatoid arthritis_Homo sapiens_hsa053231.39721022
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37840411
38Hematopoietic cell lineage_Homo sapiens_hsa046401.36336027
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33130715
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27081249
41Viral myocarditis_Homo sapiens_hsa054161.26419023
42African trypanosomiasis_Homo sapiens_hsa051431.22684701
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.20326360
44Hepatitis B_Homo sapiens_hsa051611.17848822
45Salmonella infection_Homo sapiens_hsa051321.14955699
46Chronic myeloid leukemia_Homo sapiens_hsa052201.09246932
47Acute myeloid leukemia_Homo sapiens_hsa052211.08111878
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07055672
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02094092
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99673792
51Other glycan degradation_Homo sapiens_hsa005110.97042187
52Hepatitis C_Homo sapiens_hsa051600.96205585
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.95908261
54Phagosome_Homo sapiens_hsa041450.94592491
55Prolactin signaling pathway_Homo sapiens_hsa049170.94463753
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.93271119
57Epstein-Barr virus infection_Homo sapiens_hsa051690.93233380
58Asthma_Homo sapiens_hsa053100.91547470
59Pancreatic cancer_Homo sapiens_hsa052120.91321549
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85870029
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82590216
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82234566
63Small cell lung cancer_Homo sapiens_hsa052220.77385903
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.73303661
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70341179
66Platelet activation_Homo sapiens_hsa046110.69844137
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69158425
68Viral carcinogenesis_Homo sapiens_hsa052030.64381673
69Prion diseases_Homo sapiens_hsa050200.62537208
70Type II diabetes mellitus_Homo sapiens_hsa049300.62353627
71VEGF signaling pathway_Homo sapiens_hsa043700.61685384
72MAPK signaling pathway_Homo sapiens_hsa040100.61566267
73HTLV-I infection_Homo sapiens_hsa051660.61120575
74Systemic lupus erythematosus_Homo sapiens_hsa053220.58805367
75Renal cell carcinoma_Homo sapiens_hsa052110.56334023
76Amoebiasis_Homo sapiens_hsa051460.54912091
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.52569855
78Bladder cancer_Homo sapiens_hsa052190.52274276
79Endocytosis_Homo sapiens_hsa041440.51623437
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48589310
81Complement and coagulation cascades_Homo sapiens_hsa046100.48440025
82Non-small cell lung cancer_Homo sapiens_hsa052230.46436834
83Collecting duct acid secretion_Homo sapiens_hsa049660.44920280
84Sphingolipid metabolism_Homo sapiens_hsa006000.44758600
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44637939
86Dorso-ventral axis formation_Homo sapiens_hsa043200.44216298
87Insulin resistance_Homo sapiens_hsa049310.41526494
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41092460
89Prostate cancer_Homo sapiens_hsa052150.39814672
90MicroRNAs in cancer_Homo sapiens_hsa052060.39205996
91FoxO signaling pathway_Homo sapiens_hsa040680.38651264
92Glioma_Homo sapiens_hsa052140.38098246
93Colorectal cancer_Homo sapiens_hsa052100.33986251
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33623005
95Proteoglycans in cancer_Homo sapiens_hsa052050.33602707
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33349362
97HIF-1 signaling pathway_Homo sapiens_hsa040660.32372626
98Tryptophan metabolism_Homo sapiens_hsa003800.32244713
99Inositol phosphate metabolism_Homo sapiens_hsa005620.31610442
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31386499
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.29324527
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25661221
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25474431
104p53 signaling pathway_Homo sapiens_hsa041150.25172122
105Mineral absorption_Homo sapiens_hsa049780.24093034
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22683551
107ErbB signaling pathway_Homo sapiens_hsa040120.21398111
108Choline metabolism in cancer_Homo sapiens_hsa052310.20121877
109Sulfur metabolism_Homo sapiens_hsa009200.16669384
110Notch signaling pathway_Homo sapiens_hsa043300.16585011
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11101606
112PPAR signaling pathway_Homo sapiens_hsa033200.10641024
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10106698
114GnRH signaling pathway_Homo sapiens_hsa049120.03615914
115Vibrio cholerae infection_Homo sapiens_hsa051100.01557232

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »