Rank | Gene Set | Z-score |
---|---|---|
1 | cytidine deamination (GO:0009972) | 7.63510765 |
2 | cytidine metabolic process (GO:0046087) | 7.63510765 |
3 | cytidine catabolic process (GO:0006216) | 7.63510765 |
4 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 7.30135500 |
5 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 6.82434763 |
6 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 6.47985293 |
7 | DNA deamination (GO:0045006) | 6.34901248 |
8 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 5.97789551 |
9 | actin nucleation (GO:0045010) | 5.71841803 |
10 | negative T cell selection (GO:0043383) | 5.58991060 |
11 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.44695287 |
12 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 5.10965291 |
13 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 5.02644721 |
14 | positive T cell selection (GO:0043368) | 4.96496875 |
15 | cytolysis (GO:0019835) | 4.95356293 |
16 | negative regulation of stress fiber assembly (GO:0051497) | 4.84855484 |
17 | T cell migration (GO:0072678) | 4.84425566 |
18 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 4.72122023 |
19 | positive regulation of calcium-mediated signaling (GO:0050850) | 4.65472718 |
20 | negative regulation of T cell apoptotic process (GO:0070233) | 4.65451933 |
21 | sequestering of actin monomers (GO:0042989) | 4.62652565 |
22 | positive thymic T cell selection (GO:0045059) | 4.46346497 |
23 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.44895050 |
24 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 4.40210630 |
25 | regulation of natural killer cell mediated immunity (GO:0002715) | 4.40210630 |
26 | positive regulation of tolerance induction (GO:0002645) | 4.35158647 |
27 | regulation of T cell tolerance induction (GO:0002664) | 4.31687553 |
28 | negative thymic T cell selection (GO:0045060) | 4.28903296 |
29 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 4.23800718 |
30 | positive regulation of cell killing (GO:0031343) | 4.16288778 |
31 | thymic T cell selection (GO:0045061) | 4.14612380 |
32 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 4.13615692 |
33 | regulation of activation of Janus kinase activity (GO:0010533) | 4.01308613 |
34 | regulation of defense response to virus by virus (GO:0050690) | 4.00292144 |
35 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.95873406 |
36 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.95691360 |
37 | regulation of chronic inflammatory response (GO:0002676) | 3.94702355 |
38 | regulation of regulatory T cell differentiation (GO:0045589) | 3.89464465 |
39 | T cell receptor signaling pathway (GO:0050852) | 3.85576345 |
40 | negative regulation by host of viral transcription (GO:0043922) | 3.82566496 |
41 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.82327845 |
42 | T cell selection (GO:0045058) | 3.80247164 |
43 | negative regulation of actin filament bundle assembly (GO:0032232) | 3.79931812 |
44 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.77461405 |
45 | regulation of cell killing (GO:0031341) | 3.77203979 |
46 | cellular response to interleukin-15 (GO:0071350) | 3.75939643 |
47 | purine deoxyribonucleotide catabolic process (GO:0009155) | 3.70634710 |
48 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.70141601 |
49 | positive regulation of B cell differentiation (GO:0045579) | 3.65223658 |
50 | negative regulation of calcium ion transport into cytosol (GO:0010523) | 3.60920941 |
51 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.58432978 |
52 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.57351083 |
53 | regulation of B cell differentiation (GO:0045577) | 3.57300440 |
54 | negative regulation of oxidoreductase activity (GO:0051354) | 3.55763309 |
55 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.55296816 |
56 | positive regulation of interleukin-4 production (GO:0032753) | 3.54030416 |
57 | regulation of T cell chemotaxis (GO:0010819) | 3.52796524 |
58 | positive regulation of T cell chemotaxis (GO:0010820) | 3.52796524 |
59 | negative regulation of viral genome replication (GO:0045071) | 3.52447246 |
60 | regulation of tolerance induction (GO:0002643) | 3.51410287 |
61 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 3.44490958 |
62 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.42729518 |
63 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.40677795 |
64 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.38766570 |
65 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.36385055 |
66 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.35344562 |
67 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.34388000 |
68 | regulation of calcium-mediated signaling (GO:0050848) | 3.31859768 |
69 | positive regulation of uterine smooth muscle contraction (GO:0070474) | 3.30653006 |
70 | T cell costimulation (GO:0031295) | 3.29849799 |
71 | lymphocyte costimulation (GO:0031294) | 3.28229185 |
72 | regulation of lymphocyte chemotaxis (GO:1901623) | 3.27837001 |
73 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.27278193 |
74 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.27268123 |
75 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.26084876 |
76 | positive regulation of lamellipodium assembly (GO:0010592) | 3.24599113 |
77 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.22933778 |
78 | lymphocyte migration (GO:0072676) | 3.21462114 |
79 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.18942671 |
80 | eosinophil chemotaxis (GO:0048245) | 3.15351898 |
81 | regulation of interleukin-8 secretion (GO:2000482) | 3.11486338 |
82 | regulation of T cell apoptotic process (GO:0070232) | 3.10807551 |
83 | leukocyte aggregation (GO:0070486) | 3.09975024 |
84 | mast cell activation (GO:0045576) | 3.09077747 |
85 | respiratory burst (GO:0045730) | 3.08957377 |
86 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.08653355 |
87 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.08653355 |
88 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 3.08111106 |
89 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 3.06611340 |
90 | positive regulation of lymphocyte migration (GO:2000403) | 3.06579658 |
91 | positive regulation of monocyte chemotaxis (GO:0090026) | 3.05825668 |
92 | response to interleukin-15 (GO:0070672) | 3.03438840 |
93 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.02605441 |
94 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.02605441 |
95 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.02605441 |
96 | regulation of gamma-delta T cell activation (GO:0046643) | 3.02259614 |
97 | interferon-gamma production (GO:0032609) | 3.00732177 |
98 | lymphocyte chemotaxis (GO:0048247) | 2.97738876 |
99 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.97296853 |
100 | positive regulation of defense response to virus by host (GO:0002230) | 2.96126449 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 6.90613554 |
2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.27678545 |
3 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 5.07494457 |
4 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 4.04540408 |
5 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.91787549 |
6 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.81283970 |
7 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 3.29212647 |
8 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.04465347 |
9 | MYB_26560356_Chip-Seq_TH2_Human | 2.92727119 |
10 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.86420074 |
11 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.84009053 |
12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.82899256 |
13 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.82718666 |
14 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.56436676 |
15 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.50632065 |
16 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.40999984 |
17 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.39216425 |
18 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.25111563 |
19 | VDR_22108803_ChIP-Seq_LS180_Human | 2.24931501 |
20 | MYB_26560356_Chip-Seq_TH1_Human | 2.17856674 |
21 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.16341294 |
22 | UTX_26944678_Chip-Seq_JUKART_Human | 2.13502150 |
23 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.00055468 |
24 | GATA3_26560356_Chip-Seq_TH2_Human | 1.94907241 |
25 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.83987172 |
26 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.83383916 |
27 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.73877211 |
28 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.69288835 |
29 | MAF_26560356_Chip-Seq_TH2_Human | 1.68093065 |
30 | MAF_26560356_Chip-Seq_TH1_Human | 1.59639488 |
31 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.54202116 |
32 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.46947171 |
33 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.46456881 |
34 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.44925292 |
35 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.42730207 |
36 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.40557449 |
37 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.39865525 |
38 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.38588983 |
39 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.38474342 |
40 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.31657271 |
41 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.23536573 |
42 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.22395214 |
43 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.21323760 |
44 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.20856958 |
45 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.20627151 |
46 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.19959899 |
47 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.19812628 |
48 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.18728751 |
49 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.14697965 |
50 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.13217065 |
51 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.12216045 |
52 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.09997432 |
53 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.08808537 |
54 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.07291195 |
55 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.06191353 |
56 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.04066943 |
57 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.00791507 |
58 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.99456332 |
59 | SA1_27219007_Chip-Seq_Bcells_Human | 0.98426995 |
60 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.97712819 |
61 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.96394226 |
62 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.96357279 |
63 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.95619660 |
64 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.95260136 |
65 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.94026455 |
66 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.93798277 |
67 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.92809716 |
68 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 0.92366628 |
69 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.92030697 |
70 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.92030697 |
71 | AR_20517297_ChIP-Seq_VCAP_Human | 0.91632701 |
72 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 0.91335422 |
73 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.91306090 |
74 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.91264280 |
75 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.90622740 |
76 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.89178239 |
77 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.89019134 |
78 | P300_27268052_Chip-Seq_Bcells_Human | 0.88775793 |
79 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87618721 |
80 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.86486889 |
81 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.86248038 |
82 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.85859673 |
83 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.85813512 |
84 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.85076681 |
85 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.83764634 |
86 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.83292929 |
87 | NCOR_22424771_ChIP-Seq_293T_Human | 0.83244590 |
88 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.82273264 |
89 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.82222333 |
90 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.82115270 |
91 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.81334210 |
92 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.80614128 |
93 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.79877655 |
94 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.78641348 |
95 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.78608980 |
96 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.78331638 |
97 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.78011735 |
98 | GATA3_26560356_Chip-Seq_TH1_Human | 0.77305088 |
99 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.76602855 |
100 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.76457685 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005671_abnormal_response_to | 6.41377714 |
2 | MP0009785_altered_susceptibility_to | 4.41866361 |
3 | MP0009333_abnormal_splenocyte_physiolog | 3.84074758 |
4 | MP0003763_abnormal_thymus_physiology | 3.51430217 |
5 | MP0001835_abnormal_antigen_presentation | 3.29214055 |
6 | MP0002166_altered_tumor_susceptibility | 3.23763224 |
7 | MP0005025_abnormal_response_to | 2.86240779 |
8 | MP0005000_abnormal_immune_tolerance | 2.85017204 |
9 | MP0001800_abnormal_humoral_immune | 2.56252657 |
10 | MP0002420_abnormal_adaptive_immunity | 2.46677121 |
11 | MP0001790_abnormal_immune_system | 2.43474166 |
12 | MP0005387_immune_system_phenotype | 2.43474166 |
13 | MP0002006_tumorigenesis | 2.39878913 |
14 | MP0001819_abnormal_immune_cell | 2.38371565 |
15 | MP0003866_abnormal_defecation | 2.37267635 |
16 | MP0002723_abnormal_immune_serum | 2.32726246 |
17 | MP0000685_abnormal_immune_system | 2.30525594 |
18 | MP0002102_abnormal_ear_morphology | 2.27841395 |
19 | MP0005645_abnormal_hypothalamus_physiol | 2.26244536 |
20 | MP0002148_abnormal_hypersensitivity_rea | 2.21028263 |
21 | MP0003045_fibrosis | 2.12460188 |
22 | MP0006082_CNS_inflammation | 2.02471771 |
23 | MP0002452_abnormal_antigen_presenting | 1.95214607 |
24 | MP0003436_decreased_susceptibility_to | 1.84006351 |
25 | MP0000716_abnormal_immune_system | 1.83770924 |
26 | MP0002405_respiratory_system_inflammati | 1.80802720 |
27 | MP0000703_abnormal_thymus_morphology | 1.79167494 |
28 | MP0002398_abnormal_bone_marrow | 1.79128515 |
29 | MP0001873_stomach_inflammation | 1.73524539 |
30 | MP0005075_abnormal_melanosome_morpholog | 1.72411448 |
31 | MP0003448_altered_tumor_morphology | 1.71010775 |
32 | MP0005377_hearing/vestibular/ear_phenot | 1.69979661 |
33 | MP0003878_abnormal_ear_physiology | 1.69979661 |
34 | MP0010155_abnormal_intestine_physiology | 1.68932047 |
35 | MP0001845_abnormal_inflammatory_respons | 1.60114977 |
36 | MP0002419_abnormal_innate_immunity | 1.54383219 |
37 | MP0002722_abnormal_immune_system | 1.50925322 |
38 | MP0000689_abnormal_spleen_morphology | 1.48234189 |
39 | MP0008872_abnormal_physiological_respon | 1.42730565 |
40 | MP0002429_abnormal_blood_cell | 1.37297159 |
41 | MP0000569_abnormal_digit_pigmentation | 1.36218647 |
42 | MP0002933_joint_inflammation | 1.35500486 |
43 | MP0001905_abnormal_dopamine_level | 1.34523247 |
44 | MP0001919_abnormal_reproductive_system | 1.31716701 |
45 | MP0002693_abnormal_pancreas_physiology | 1.29266502 |
46 | MP0003646_muscle_fatigue | 1.27295008 |
47 | MP0009764_decreased_sensitivity_to | 1.25211831 |
48 | MP0005464_abnormal_platelet_physiology | 1.23500950 |
49 | MP0008469_abnormal_protein_level | 1.22080843 |
50 | MP0001501_abnormal_sleep_pattern | 1.18547249 |
51 | MP0002163_abnormal_gland_morphology | 1.17078416 |
52 | MP0002736_abnormal_nociception_after | 1.16273526 |
53 | MP0003724_increased_susceptibility_to | 1.11706678 |
54 | MP0003806_abnormal_nucleotide_metabolis | 1.04489833 |
55 | MP0008875_abnormal_xenobiotic_pharmacok | 1.03577651 |
56 | MP0005379_endocrine/exocrine_gland_phen | 1.01852896 |
57 | MP0003137_abnormal_impulse_conducting | 1.00195543 |
58 | MP0004381_abnormal_hair_follicle | 0.99020366 |
59 | MP0005166_decreased_susceptibility_to | 0.97459325 |
60 | MP0004947_skin_inflammation | 0.97237390 |
61 | MP0002277_abnormal_respiratory_mucosa | 0.95085616 |
62 | MP0009763_increased_sensitivity_to | 0.93900183 |
63 | MP0001968_abnormal_touch/_nociception | 0.88652055 |
64 | MP0004134_abnormal_chest_morphology | 0.87964694 |
65 | MP0005389_reproductive_system_phenotype | 0.87874578 |
66 | MP0001533_abnormal_skeleton_physiology | 0.86561819 |
67 | MP0004145_abnormal_muscle_electrophysio | 0.83553796 |
68 | MP0002138_abnormal_hepatobiliary_system | 0.83377581 |
69 | MP0002019_abnormal_tumor_incidence | 0.83100343 |
70 | MP0003011_delayed_dark_adaptation | 0.82638608 |
71 | MP0002638_abnormal_pupillary_reflex | 0.80970363 |
72 | MP0001661_extended_life_span | 0.80873204 |
73 | MP0006036_abnormal_mitochondrial_physio | 0.79797566 |
74 | MP0005636_abnormal_mineral_homeostasis | 0.79612720 |
75 | MP0009643_abnormal_urine_homeostasis | 0.79377471 |
76 | MP0003786_premature_aging | 0.78862926 |
77 | MP0002837_dystrophic_cardiac_calcinosis | 0.74271844 |
78 | MP0000372_irregular_coat_pigmentation | 0.73742029 |
79 | MP0002095_abnormal_skin_pigmentation | 0.72279926 |
80 | MP0002132_abnormal_respiratory_system | 0.71963619 |
81 | MP0001765_abnormal_ion_homeostasis | 0.69906449 |
82 | MP0005310_abnormal_salivary_gland | 0.67606371 |
83 | MP0003252_abnormal_bile_duct | 0.67367274 |
84 | MP0005174_abnormal_tail_pigmentation | 0.63577681 |
85 | MP0002653_abnormal_ependyma_morphology | 0.63030174 |
86 | MP0008873_increased_physiological_sensi | 0.62147126 |
87 | MP0005410_abnormal_fertilization | 0.60457274 |
88 | MP0001542_abnormal_bone_strength | 0.58825829 |
89 | MP0003075_altered_response_to | 0.57691673 |
90 | MP0002136_abnormal_kidney_physiology | 0.56777479 |
91 | MP0005257_abnormal_intraocular_pressure | 0.54709179 |
92 | MP0001853_heart_inflammation | 0.53675664 |
93 | MP0004742_abnormal_vestibular_system | 0.53057101 |
94 | MP0002168_other_aberrant_phenotype | 0.52585602 |
95 | MP0004130_abnormal_muscle_cell | 0.52236525 |
96 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.52154782 |
97 | MP0005551_abnormal_eye_electrophysiolog | 0.51420896 |
98 | MP0008995_early_reproductive_senescence | 0.50170508 |
99 | MP0000604_amyloidosis | 0.50074442 |
100 | MP0001119_abnormal_female_reproductive | 0.48921399 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Aplastic anemia (HP:0001915) | 6.47627778 |
2 | Abnormality of T cell number (HP:0011839) | 6.13288673 |
3 | T lymphocytopenia (HP:0005403) | 6.07900061 |
4 | Autoimmune hemolytic anemia (HP:0001890) | 5.63559676 |
5 | Increased IgM level (HP:0003496) | 5.29689350 |
6 | Hypoproteinemia (HP:0003075) | 4.95569423 |
7 | IgG deficiency (HP:0004315) | 4.66547188 |
8 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.52714343 |
9 | Severe combined immunodeficiency (HP:0004430) | 4.52551465 |
10 | Abnormality of T cells (HP:0002843) | 4.42742258 |
11 | Abnormality of B cell number (HP:0010975) | 4.13408246 |
12 | Autoimmune thrombocytopenia (HP:0001973) | 3.63310037 |
13 | Chronic diarrhea (HP:0002028) | 3.61377307 |
14 | Combined immunodeficiency (HP:0005387) | 3.56684215 |
15 | 3-Methylglutaconic aciduria (HP:0003535) | 3.50223489 |
16 | Encephalitis (HP:0002383) | 3.45805594 |
17 | Congenital stationary night blindness (HP:0007642) | 3.43786087 |
18 | Abnormality of eosinophils (HP:0001879) | 3.43754036 |
19 | Thyroiditis (HP:0100646) | 3.34106631 |
20 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.32894817 |
21 | Increased intramyocellular lipid droplets (HP:0012240) | 3.32212921 |
22 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.21125559 |
23 | Eosinophilia (HP:0001880) | 3.19735662 |
24 | Mitochondrial inheritance (HP:0001427) | 3.15265571 |
25 | Pancytopenia (HP:0001876) | 3.12006341 |
26 | Acute necrotizing encephalopathy (HP:0006965) | 2.98132988 |
27 | Oral leukoplakia (HP:0002745) | 2.96136783 |
28 | Abnormality of macrophages (HP:0004311) | 2.94659135 |
29 | Stomatitis (HP:0010280) | 2.92621709 |
30 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.92041160 |
31 | IgM deficiency (HP:0002850) | 2.88769751 |
32 | Abnormality of T cell physiology (HP:0011840) | 2.88217121 |
33 | Hepatocellular necrosis (HP:0001404) | 2.85648069 |
34 | B lymphocytopenia (HP:0010976) | 2.81494278 |
35 | Acute hepatic failure (HP:0006554) | 2.80227803 |
36 | Stomach cancer (HP:0012126) | 2.80134173 |
37 | Hypergammaglobulinemia (HP:0010702) | 2.74797262 |
38 | Hepatic necrosis (HP:0002605) | 2.74567064 |
39 | Increased muscle lipid content (HP:0009058) | 2.74008535 |
40 | Myositis (HP:0100614) | 2.72023785 |
41 | Retrobulbar optic neuritis (HP:0100654) | 2.64388909 |
42 | Optic neuritis (HP:0100653) | 2.64388909 |
43 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.62043181 |
44 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.62043181 |
45 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.60953083 |
46 | Recurrent bronchitis (HP:0002837) | 2.52851719 |
47 | Leukocytosis (HP:0001974) | 2.50586751 |
48 | Granulocytopenia (HP:0001913) | 2.50501857 |
49 | Lymphopenia (HP:0001888) | 2.50243476 |
50 | Progressive macrocephaly (HP:0004481) | 2.49783639 |
51 | Amyotrophic lateral sclerosis (HP:0007354) | 2.48419650 |
52 | Lymphoma (HP:0002665) | 2.46303108 |
53 | Meningitis (HP:0001287) | 2.46180741 |
54 | Keratoconjunctivitis sicca (HP:0001097) | 2.38282035 |
55 | Generalized aminoaciduria (HP:0002909) | 2.37572644 |
56 | Recurrent viral infections (HP:0004429) | 2.36333882 |
57 | Increased CSF lactate (HP:0002490) | 2.35375074 |
58 | Abnormality of the pons (HP:0007361) | 2.29186925 |
59 | Keratoconjunctivitis (HP:0001096) | 2.26983152 |
60 | Type I transferrin isoform profile (HP:0003642) | 2.26597248 |
61 | Acute encephalopathy (HP:0006846) | 2.23645238 |
62 | Vasculitis (HP:0002633) | 2.22031967 |
63 | Abnormality of the renal cortex (HP:0011035) | 2.21710316 |
64 | Gastrointestinal infarctions (HP:0005244) | 2.20736473 |
65 | Renal cortical cysts (HP:0000803) | 2.16473874 |
66 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.14971689 |
67 | Orchitis (HP:0100796) | 2.14267412 |
68 | Recurrent skin infections (HP:0001581) | 2.09617697 |
69 | Pustule (HP:0200039) | 2.08249579 |
70 | Premature graying of hair (HP:0002216) | 2.06202392 |
71 | Joint swelling (HP:0001386) | 2.04903027 |
72 | Hypoplasia of the pons (HP:0012110) | 2.03149443 |
73 | Severe visual impairment (HP:0001141) | 1.99945117 |
74 | Abnormality of the prostate (HP:0008775) | 1.98452603 |
75 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.97807834 |
76 | Pulmonary infiltrates (HP:0002113) | 1.97092662 |
77 | Recurrent cutaneous fungal infections (HP:0011370) | 1.96997074 |
78 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.96997074 |
79 | Gangrene (HP:0100758) | 1.95178926 |
80 | Increased hepatocellular lipid droplets (HP:0006565) | 1.94072723 |
81 | Hypoalbuminemia (HP:0003073) | 1.91445440 |
82 | Abnormal albumin level (HP:0012116) | 1.91445440 |
83 | Dicarboxylic aciduria (HP:0003215) | 1.89064375 |
84 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.89064375 |
85 | Recurrent fungal infections (HP:0002841) | 1.87956237 |
86 | Cellular immunodeficiency (HP:0005374) | 1.86227335 |
87 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.86082700 |
88 | Recurrent bacterial skin infections (HP:0005406) | 1.85974293 |
89 | Chronic obstructive pulmonary disease (HP:0006510) | 1.81907556 |
90 | Obstructive lung disease (HP:0006536) | 1.81907556 |
91 | Ketoacidosis (HP:0001993) | 1.80482800 |
92 | Hypochromic anemia (HP:0001931) | 1.80198037 |
93 | Recurrent otitis media (HP:0000403) | 1.79144446 |
94 | Attenuation of retinal blood vessels (HP:0007843) | 1.75028384 |
95 | Hemiplegia (HP:0002301) | 1.74248076 |
96 | Cerebral edema (HP:0002181) | 1.73807767 |
97 | Bronchitis (HP:0012387) | 1.73336732 |
98 | Bronchiectasis (HP:0002110) | 1.71067677 |
99 | Exercise intolerance (HP:0003546) | 1.70734193 |
100 | Renal Fanconi syndrome (HP:0001994) | 1.70731803 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDR | 6.78938567 |
2 | TESK2 | 5.84906206 |
3 | TXK | 4.69386903 |
4 | TESK1 | 3.46084196 |
5 | SCYL2 | 3.43815049 |
6 | MAP3K12 | 2.71402975 |
7 | LIMK1 | 2.38275232 |
8 | MAP4K1 | 2.36481475 |
9 | VRK2 | 2.35714574 |
10 | ITK | 2.32958404 |
11 | PASK | 2.20321811 |
12 | TLK1 | 2.15928398 |
13 | ADRBK2 | 2.10504980 |
14 | BCKDK | 1.91616943 |
15 | PINK1 | 1.87917427 |
16 | WNK4 | 1.61027693 |
17 | ZAK | 1.44371676 |
18 | ZAP70 | 1.41702151 |
19 | MAP3K11 | 1.41640252 |
20 | CAMKK2 | 1.31991658 |
21 | CSK | 1.27799947 |
22 | PRKCQ | 1.27702707 |
23 | GRK1 | 1.26955279 |
24 | GRK7 | 1.26409210 |
25 | MYLK | 1.25410372 |
26 | BUB1 | 1.25087566 |
27 | SYK | 1.25062057 |
28 | FES | 1.23728062 |
29 | GRK6 | 1.21974979 |
30 | IKBKE | 1.19717351 |
31 | LCK | 1.18417397 |
32 | VRK1 | 1.16977901 |
33 | TEC | 1.13523409 |
34 | DAPK1 | 1.11033052 |
35 | TAOK3 | 1.08967415 |
36 | NME1 | 1.06107555 |
37 | MST4 | 1.01983474 |
38 | CAMKK1 | 1.01838081 |
39 | MAP2K6 | 0.98321651 |
40 | BTK | 0.97398737 |
41 | MAPKAPK3 | 0.91724937 |
42 | TAOK2 | 0.91473276 |
43 | IRAK4 | 0.90808271 |
44 | RIPK4 | 0.85330364 |
45 | ROCK1 | 0.82631828 |
46 | CDK19 | 0.81855166 |
47 | NEK9 | 0.80536810 |
48 | FRK | 0.79471320 |
49 | CLK1 | 0.79351178 |
50 | EIF2AK3 | 0.76248218 |
51 | STK39 | 0.73104609 |
52 | OXSR1 | 0.69924564 |
53 | LYN | 0.69461110 |
54 | RPS6KA4 | 0.65861236 |
55 | JAK3 | 0.64605183 |
56 | ILK | 0.61765526 |
57 | RPS6KA5 | 0.60115748 |
58 | BLK | 0.57834795 |
59 | ERBB3 | 0.53625746 |
60 | FYN | 0.52456023 |
61 | TRPM7 | 0.51493897 |
62 | MAP4K2 | 0.48105772 |
63 | IKBKB | 0.47966868 |
64 | HCK | 0.47023245 |
65 | PIK3CG | 0.46825893 |
66 | INSRR | 0.44933886 |
67 | IGF1R | 0.44144953 |
68 | PIM1 | 0.43799590 |
69 | OBSCN | 0.43414121 |
70 | NEK6 | 0.37970152 |
71 | GRK5 | 0.37950165 |
72 | MAP3K5 | 0.35371937 |
73 | ADRBK1 | 0.33524563 |
74 | PRKCA | 0.32886035 |
75 | TIE1 | 0.31472038 |
76 | AURKA | 0.30431762 |
77 | MAP3K3 | 0.30133343 |
78 | STK10 | 0.29924328 |
79 | CAMK2A | 0.28412036 |
80 | CAMK1 | 0.27321009 |
81 | JAK2 | 0.24692997 |
82 | INSR | 0.23726432 |
83 | NUAK1 | 0.23215053 |
84 | MUSK | 0.22506351 |
85 | PRKACA | 0.22383193 |
86 | KIT | 0.22169936 |
87 | CSNK1G3 | 0.21565105 |
88 | PRKCH | 0.21251808 |
89 | DAPK3 | 0.20615043 |
90 | PAK1 | 0.19937984 |
91 | PDK1 | 0.18914691 |
92 | MAPKAPK2 | 0.18554115 |
93 | TBK1 | 0.18263373 |
94 | ERBB2 | 0.16674445 |
95 | ABL1 | 0.16407444 |
96 | TAOK1 | 0.16353794 |
97 | LRRK2 | 0.15605199 |
98 | PRKCD | 0.15562882 |
99 | PIM2 | 0.14361082 |
100 | CSNK2A1 | 0.11620651 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 7.00890929 |
2 | Proteasome_Homo sapiens_hsa03050 | 4.93462351 |
3 | Antigen processing and presentation_Homo sapiens_hsa04612 | 3.57172178 |
4 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 3.06985153 |
5 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 3.03553549 |
6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.96276961 |
7 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.84130451 |
8 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.76412866 |
9 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.54347567 |
10 | Parkinsons disease_Homo sapiens_hsa05012 | 2.48122293 |
11 | Allograft rejection_Homo sapiens_hsa05330 | 2.43651182 |
12 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.36467399 |
13 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.10357894 |
14 | Measles_Homo sapiens_hsa05162 | 1.76016063 |
15 | Alzheimers disease_Homo sapiens_hsa05010 | 1.70440979 |
16 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.64738392 |
17 | Protein export_Homo sapiens_hsa03060 | 1.63316773 |
18 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.59232968 |
19 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.58950240 |
20 | Ribosome_Homo sapiens_hsa03010 | 1.55033989 |
21 | Malaria_Homo sapiens_hsa05144 | 1.26980888 |
22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.26921680 |
23 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.25939861 |
24 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.25372225 |
25 | Salmonella infection_Homo sapiens_hsa05132 | 1.14426587 |
26 | Shigellosis_Homo sapiens_hsa05131 | 1.11634601 |
27 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.11576203 |
28 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.08098592 |
29 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.06799281 |
30 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.05512191 |
31 | Viral myocarditis_Homo sapiens_hsa05416 | 0.98896639 |
32 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.97620893 |
33 | Phototransduction_Homo sapiens_hsa04744 | 0.96199371 |
34 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.95142574 |
35 | RNA polymerase_Homo sapiens_hsa03020 | 0.91666095 |
36 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.89893018 |
37 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.88400948 |
38 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.87734360 |
39 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.86259448 |
40 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.85008286 |
41 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.83979980 |
42 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.79927756 |
43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.75704714 |
44 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.73640342 |
45 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.63466072 |
46 | Peroxisome_Homo sapiens_hsa04146 | 0.60910575 |
47 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.60485209 |
48 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.58600119 |
49 | Retinol metabolism_Homo sapiens_hsa00830 | 0.58340083 |
50 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.56576203 |
51 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.55363806 |
52 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.55092455 |
53 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.54586945 |
54 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.52780006 |
55 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.48792574 |
56 | Asthma_Homo sapiens_hsa05310 | 0.48033582 |
57 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.46317033 |
58 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.45727540 |
59 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.45269645 |
60 | Legionellosis_Homo sapiens_hsa05134 | 0.44628105 |
61 | Prion diseases_Homo sapiens_hsa05020 | 0.42010033 |
62 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.41855781 |
63 | ABC transporters_Homo sapiens_hsa02010 | 0.41137830 |
64 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.40555820 |
65 | Olfactory transduction_Homo sapiens_hsa04740 | 0.40075743 |
66 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.40013663 |
67 | Homologous recombination_Homo sapiens_hsa03440 | 0.40002272 |
68 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.39751368 |
69 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.38880278 |
70 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.38570906 |
71 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.38073444 |
72 | Endocytosis_Homo sapiens_hsa04144 | 0.36049482 |
73 | Pertussis_Homo sapiens_hsa05133 | 0.35658319 |
74 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.34897463 |
75 | Apoptosis_Homo sapiens_hsa04210 | 0.34502678 |
76 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.33254690 |
77 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.32558119 |
78 | Purine metabolism_Homo sapiens_hsa00230 | 0.32151937 |
79 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.31555389 |
80 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.29833980 |
81 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.28504117 |
82 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.27228718 |
83 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.24950964 |
84 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.24470949 |
85 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.23582587 |
86 | Morphine addiction_Homo sapiens_hsa05032 | 0.23572001 |
87 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.23350369 |
88 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.22018759 |
89 | Spliceosome_Homo sapiens_hsa03040 | 0.20137208 |
90 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.19771453 |
91 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.19484127 |
92 | Metabolic pathways_Homo sapiens_hsa01100 | 0.18032882 |
93 | Leishmaniasis_Homo sapiens_hsa05140 | 0.17828078 |
94 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.17522364 |
95 | Taste transduction_Homo sapiens_hsa04742 | 0.17165267 |
96 | DNA replication_Homo sapiens_hsa03030 | 0.17012755 |
97 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.15611111 |
98 | Salivary secretion_Homo sapiens_hsa04970 | 0.15467016 |
99 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.15461955 |
100 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.14964690 |