CDA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)6.88077418
2neutrophil activation involved in immune response (GO:0002283)6.33247358
3response to peptidoglycan (GO:0032494)5.93917219
4urate metabolic process (GO:0046415)5.90081148
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.82907214
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.82907214
7modulation by symbiont of host immune response (GO:0052553)5.82907214
8positive regulation by symbiont of host defense response (GO:0052509)5.82907214
9modulation by symbiont of host defense response (GO:0052031)5.82907214
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.82907214
11drug transport (GO:0015893)5.82349085
12detection of other organism (GO:0098543)5.75478440
13detection of bacterium (GO:0016045)5.61161254
14drug catabolic process (GO:0042737)5.55177199
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.47898082
16L-phenylalanine metabolic process (GO:0006558)5.37725830
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.37725830
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.35326079
19negative regulation of cell killing (GO:0031342)5.35326079
20L-phenylalanine catabolic process (GO:0006559)5.25620959
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.25620959
22lysine catabolic process (GO:0006554)5.19632975
23lysine metabolic process (GO:0006553)5.19632975
24leukocyte migration involved in inflammatory response (GO:0002523)4.84169749
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.83641779
26macrophage activation involved in immune response (GO:0002281)4.82949624
27organic cation transport (GO:0015695)4.80503494
28neutrophil activation (GO:0042119)4.80396823
29aminoglycoside antibiotic metabolic process (GO:0030647)4.74878115
30detection of external biotic stimulus (GO:0098581)4.74110449
31antigen processing and presentation of endogenous antigen (GO:0019883)4.73700248
32cysteine metabolic process (GO:0006534)4.72127807
33leukocyte aggregation (GO:0070486)4.64809616
34exogenous drug catabolic process (GO:0042738)4.61181417
35cellular ketone body metabolic process (GO:0046950)4.53423881
36phosphate ion transport (GO:0006817)4.50491393
37positive regulation of gamma-delta T cell activation (GO:0046645)4.50105834
38glyoxylate metabolic process (GO:0046487)4.45612914
39granulocyte activation (GO:0036230)4.42508631
40detection of molecule of bacterial origin (GO:0032490)4.40642139
41cellular extravasation (GO:0045123)4.40160573
42respiratory burst (GO:0045730)4.38607416
43purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.35600213
443-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.35600213
45aromatic amino acid family catabolic process (GO:0009074)4.35440811
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.34337279
47negative regulation of interleukin-12 production (GO:0032695)4.31939487
48flavonoid metabolic process (GO:0009812)4.22524735
49positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.20932075
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.18989059
51response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.17962345
52response to host immune response (GO:0052572)4.17962345
53intestinal absorption (GO:0050892)4.17614576
54regulation of interferon-beta biosynthetic process (GO:0045357)4.14586547
55homocysteine metabolic process (GO:0050667)4.13177311
56detection of biotic stimulus (GO:0009595)4.11302931
57short-chain fatty acid metabolic process (GO:0046459)4.10169308
58regulation of mast cell degranulation (GO:0043304)3.95917144
59fructose metabolic process (GO:0006000)3.94376616
60response to host (GO:0075136)3.94217088
61response to host defenses (GO:0052200)3.94217088
62response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.94217088
63immunoglobulin mediated immune response (GO:0016064)3.93368344
64ketone body metabolic process (GO:1902224)3.90748177
65nonribosomal peptide biosynthetic process (GO:0019184)3.86784616
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.84571131
67ATP synthesis coupled proton transport (GO:0015986)3.84571131
68negative regulation of lymphocyte mediated immunity (GO:0002707)3.82819260
69myeloid cell activation involved in immune response (GO:0002275)3.82583742
70response to mercury ion (GO:0046689)3.78353146
71neutrophil mediated immunity (GO:0002446)3.78145064
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.75646070
73phosphate ion transmembrane transport (GO:0035435)3.74033076
74indole-containing compound catabolic process (GO:0042436)3.72593087
75indolalkylamine catabolic process (GO:0046218)3.72593087
76tryptophan catabolic process (GO:0006569)3.72593087
77excretion (GO:0007588)3.71820217
78sulfur amino acid catabolic process (GO:0000098)3.71815327
79regulation of B cell receptor signaling pathway (GO:0050855)3.71460093
80regulation of myeloid leukocyte mediated immunity (GO:0002886)3.68553797
81glutathione biosynthetic process (GO:0006750)3.68488115
82quaternary ammonium group transport (GO:0015697)3.64354435
83proline metabolic process (GO:0006560)3.63737481
84respiratory electron transport chain (GO:0022904)3.63149767
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.62847626
86regulation of mast cell activation involved in immune response (GO:0033006)3.62728118
87vitamin D metabolic process (GO:0042359)3.62529895
88tryptophan metabolic process (GO:0006568)3.58644415
89modified amino acid transport (GO:0072337)3.57596398
90electron transport chain (GO:0022900)3.57349910
91renal absorption (GO:0070293)3.56751777
92intestinal cholesterol absorption (GO:0030299)3.54959203
93microglial cell activation (GO:0001774)3.54695767
94production of molecular mediator involved in inflammatory response (GO:0002532)3.54074313
95regulation of leukocyte degranulation (GO:0043300)3.53147111
96fatty acid beta-oxidation (GO:0006635)3.52769365
97leukocyte degranulation (GO:0043299)3.52134755
98cellular modified amino acid catabolic process (GO:0042219)3.51547486
99tricarboxylic acid metabolic process (GO:0072350)3.51532001
100positive regulation of mast cell activation (GO:0033005)3.47378398
101negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.44799046
102negative regulation of leukocyte mediated immunity (GO:0002704)3.44746548
103macrophage activation (GO:0042116)3.44215382
104amino-acid betaine metabolic process (GO:0006577)3.43540640
105drug metabolic process (GO:0017144)3.43472134
106aromatic amino acid family metabolic process (GO:0009072)3.40730624
107aspartate family amino acid catabolic process (GO:0009068)3.38929258
108NADH metabolic process (GO:0006734)3.38674237
109regulation of T-helper 2 cell differentiation (GO:0045628)3.37251454
110glutathione derivative biosynthetic process (GO:1901687)3.33639749
111glutathione derivative metabolic process (GO:1901685)3.33639749
112regulation of mast cell activation (GO:0033003)3.32827512
113glutathione metabolic process (GO:0006749)3.29982563
114sulfur compound transport (GO:0072348)3.28644853
115glycoside metabolic process (GO:0016137)3.27746157
116uronic acid metabolic process (GO:0006063)3.27466710
117glucuronate metabolic process (GO:0019585)3.27466710
118lipopolysaccharide-mediated signaling pathway (GO:0031663)3.26094667
119fatty acid oxidation (GO:0019395)3.26085895
120serine family amino acid catabolic process (GO:0009071)3.25182564
121peptide catabolic process (GO:0043171)3.25018467
122lipid oxidation (GO:0034440)3.19918627
123type I interferon signaling pathway (GO:0060337)3.18027899
124cellular response to type I interferon (GO:0071357)3.18027899
125fatty acid catabolic process (GO:0009062)3.17779456
126kynurenine metabolic process (GO:0070189)3.17760824
127negative regulation of interleukin-6 production (GO:0032715)3.16924735
128B cell mediated immunity (GO:0019724)3.16729286
129response to muramyl dipeptide (GO:0032495)3.15797148
130response to type I interferon (GO:0034340)3.13867850
131neutrophil chemotaxis (GO:0030593)3.13297482
132vitamin transport (GO:0051180)3.12966585
133positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12231648
134transepithelial transport (GO:0070633)3.11964845
135negative regulation of T cell mediated immunity (GO:0002710)3.11953818
136regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.11932065
137regulation of gamma-delta T cell activation (GO:0046643)3.11210059
138peptide biosynthetic process (GO:0043043)3.10403043
139germinal center formation (GO:0002467)3.10106777
140cellular glucuronidation (GO:0052695)3.09499200
141regulation of regulated secretory pathway (GO:1903305)3.09494639
142response to interleukin-15 (GO:0070672)3.08958761
143positive regulation of mast cell degranulation (GO:0043306)3.08127683
144positive regulation of mast cell activation involved in immune response (GO:0033008)3.08127683
145regulation of cholesterol homeostasis (GO:2000188)3.08017283
146myeloid leukocyte mediated immunity (GO:0002444)3.07024697
147carnitine metabolic process (GO:0009437)3.06631685
148angiotensin maturation (GO:0002003)3.05047549
149neutrophil migration (GO:1990266)3.04983233
150antigen processing and presentation via MHC class Ib (GO:0002475)3.02548775
151positive regulation of cellular amide metabolic process (GO:0034250)3.00480696
152branched-chain amino acid metabolic process (GO:0009081)3.00344992
153aldehyde catabolic process (GO:0046185)2.99485322
154monocarboxylic acid catabolic process (GO:0072329)2.96778829
155sulfate transmembrane transport (GO:1902358)2.96206613
156defense response to protozoan (GO:0042832)2.94907967
157negative regulation of phagocytosis (GO:0050765)2.94048487
158positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.93814145
159benzene-containing compound metabolic process (GO:0042537)2.93670793
160positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93605898
161superoxide anion generation (GO:0042554)2.93274984
162trivalent inorganic anion homeostasis (GO:0072506)2.91193015
163phosphate ion homeostasis (GO:0055062)2.91193015
164indolalkylamine metabolic process (GO:0006586)2.90990394
165regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.90922331
166calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.90858073
167myeloid leukocyte activation (GO:0002274)2.90599629
168cellular amino acid catabolic process (GO:0009063)2.90513213
169bile acid and bile salt transport (GO:0015721)2.88635623
170negative regulation of cytokine production involved in immune response (GO:0002719)2.88484240
171regulation of dendritic cell antigen processing and presentation (GO:0002604)2.88432999
172neurotransmitter biosynthetic process (GO:0042136)2.88144019
173regulation of bile acid biosynthetic process (GO:0070857)2.87416548
174negative regulation of glycoprotein biosynthetic process (GO:0010561)2.86516296
175serine family amino acid metabolic process (GO:0009069)2.85977042
176ribonucleoside bisphosphate metabolic process (GO:0033875)2.85876948
177nucleoside bisphosphate metabolic process (GO:0033865)2.85876948
178purine nucleoside bisphosphate metabolic process (GO:0034032)2.85876948
179alkaloid metabolic process (GO:0009820)2.85719603
180response to phenylpropanoid (GO:0080184)2.84522580
181glutamate metabolic process (GO:0006536)2.83720055
182dendritic cell migration (GO:0036336)2.83107026
183endocrine pancreas development (GO:0031018)2.82689185
184acetyl-CoA metabolic process (GO:0006084)2.82138201
185positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.80337949
186positive regulation of regulated secretory pathway (GO:1903307)2.79141155
187positive regulation of Cdc42 GTPase activity (GO:0043089)2.77837756
188positive regulation of toll-like receptor signaling pathway (GO:0034123)2.76744598
189regulation of T cell tolerance induction (GO:0002664)2.76132502
190cellular response to interleukin-15 (GO:0071350)2.75415427
191regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.73883008
192negative regulation of interleukin-8 production (GO:0032717)2.73304977
193response to fungus (GO:0009620)2.70937733
194negative regulation of innate immune response (GO:0045824)2.69259767
195dendritic cell chemotaxis (GO:0002407)2.68890051
196interferon-gamma-mediated signaling pathway (GO:0060333)2.68863951
197positive regulation of interleukin-17 production (GO:0032740)2.68216960
198negative regulation of T-helper cell differentiation (GO:0045623)2.68195290
199negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68195290
200regulation of tolerance induction (GO:0002643)2.68061947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.50668768
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.99155428
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.50073025
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.22074344
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.07530205
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.94986238
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.82880758
8* LXR_22158963_ChIP-Seq_LIVER_Mouse3.76371401
9* HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.74122895
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.71909526
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.55099855
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.41156162
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02132802
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.94874093
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.94814505
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89033115
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.86750092
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.77273313
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.76255789
20SPI1_23547873_ChIP-Seq_NB4_Human2.66948687
21VDR_21846776_ChIP-Seq_THP-1_Human2.66826407
22VDR_24763502_ChIP-Seq_THP-1_Human2.64822457
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.64067588
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.52461354
25SPI1_23127762_ChIP-Seq_K562_Human2.46414961
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.46109822
27SOX2_27498859_Chip-Seq_STOMACH_Mouse2.44753787
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.41421769
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40785149
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37160379
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.35978548
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25783922
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24564392
34RUNX1_22412390_ChIP-Seq_EML_Mouse2.23362201
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.22358403
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21335111
37SOX2_20726797_ChIP-Seq_SW620_Human2.18868794
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17402064
39RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16851450
40BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12191399
41MAF_26560356_Chip-Seq_TH1_Human2.09548729
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09406134
43STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07429218
44ESR1_21235772_ChIP-Seq_MCF-7_Human2.04787456
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01854568
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95724698
47GATA4_25053715_ChIP-Seq_YYC3_Human1.92992700
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.84745517
49* UTX_26944678_Chip-Seq_JUKART_Human1.82979246
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82110810
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.81496052
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79721014
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76798553
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75827791
55GATA6_25053715_ChIP-Seq_YYC3_Human1.74827340
56MYB_26560356_Chip-Seq_TH2_Human1.71702284
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70906384
58RUNX_20019798_ChIP-Seq_JUKART_Human1.69371250
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69128655
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.66672831
61TCF7_22412390_ChIP-Seq_EML_Mouse1.65195968
62SCL_19346495_ChIP-Seq_HPC-7_Human1.65059155
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.64894102
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64811457
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62251336
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61911045
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60560243
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60408408
69CLOCK_20551151_ChIP-Seq_293T_Human1.60364350
70MAF_26560356_Chip-Seq_TH2_Human1.58842095
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57755739
72MYB_26560356_Chip-Seq_TH1_Human1.57239995
73MYC_22102868_ChIP-Seq_BL_Human1.55668935
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.55494374
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54830759
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54512124
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52530844
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51278961
79VDR_24787735_ChIP-Seq_THP-1_Human1.51010759
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50855907
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50599819
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48795265
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46369352
84VDR_22108803_ChIP-Seq_LS180_Human1.44746103
85* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41911974
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41684589
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41211865
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.40460912
89GATA1_19941827_ChIP-Seq_MEL_Mouse1.40418214
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.39920546
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39718453
92KDM2B_26808549_Chip-Seq_DND41_Human1.39691094
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39220228
94TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.38809734
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38182122
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35541004
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35300559
98* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34503257
99RACK7_27058665_Chip-Seq_MCF-7_Human1.29847655
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29338105
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28463983
102GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26618968
103CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24792912
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24288122
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20333935
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18183052
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17667858
108BCOR_27268052_Chip-Seq_Bcells_Human1.17059847
109ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16719368
110GATA3_27048872_Chip-Seq_THYMUS_Human1.13437532
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13272080
112BCL6_27268052_Chip-Seq_Bcells_Human1.12467581
113RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12244979
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11940521
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11178602
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09022223
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08848758
118* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07606638
119LXR_22292898_ChIP-Seq_THP-1_Human1.06295108
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06214963
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06053464
122GATA1_19941826_ChIP-Seq_K562_Human1.05310499
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04308494
124FOXA2_19822575_ChIP-Seq_HepG2_Human1.04207537
125* ATF3_27146783_Chip-Seq_COLON_Human1.04129632
126PU_27001747_Chip-Seq_BMDM_Mouse1.03860286
127NCOR1_26117541_ChIP-Seq_K562_Human1.03541037
128CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02536875
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02322508
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02210902
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00726740
132CTCF_27219007_Chip-Seq_Bcells_Human1.00355168
133PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00212758
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99116388
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98372257
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98028021
137* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97460953
138PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96282480
139SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95656362
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95656362
141GATA3_26560356_Chip-Seq_TH2_Human0.94395500
142SPI1_20517297_ChIP-Seq_HL60_Human0.93843600
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93298263
144NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92502069
145CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91546389
146ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91431328
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.91295990
148TET1_21451524_ChIP-Seq_MESCs_Mouse0.91012327
149ZNF263_19887448_ChIP-Seq_K562_Human0.90867557
150* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90459246
151EGR1_19032775_ChIP-ChIP_M12_Human0.89824298
152BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89285929
153GATA3_24758297_ChIP-Seq_MCF-7_Human0.89045740
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87204474
155NCOR_22424771_ChIP-Seq_293T_Human0.81735214
156FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81726005
157CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81294441
158TAF2_19829295_ChIP-Seq_ESCs_Human0.80878533
159PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80421485
160TP63_22573176_ChIP-Seq_HFKS_Human0.79943720
161CTCF_20526341_ChIP-Seq_ESCs_Human0.79753013
162AR_20517297_ChIP-Seq_VCAP_Human0.78811754
163* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77837594
164PIAS1_25552417_ChIP-Seq_VCAP_Human0.77468990
165CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77155596
166KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77103166
167EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77068319
168P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.76105983
169ERG_21242973_ChIP-ChIP_JURKAT_Human0.76043825
170* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75688317
171* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.75677429
172TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75581773
173GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.73808544
174SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.73655515
175* MYC_19915707_ChIP-ChIP_AK7_Human0.72311256
176CDX2_22108803_ChIP-Seq_LS180_Human0.72141805
177ERG_20517297_ChIP-Seq_VCAP_Human0.72070756
178CSB_26484114_Chip-Seq_FIBROBLAST_Human0.71601938
179* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.71461008
180GATA3_21867929_ChIP-Seq_CD8_Mouse0.71406568
181FOXA1_25552417_ChIP-Seq_VCAP_Human0.71254264
182STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71202650
183POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.70954497
184RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70182558
185BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70091919
186NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67607495
187NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67607495
188CREB1_26743006_Chip-Seq_LNCaP_Human0.67186283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.66504541
2MP0002139_abnormal_hepatobiliary_system5.48874131
3MP0004043_abnormal_pH_regulation4.69153748
4MP0003724_increased_susceptibility_to4.57594309
5MP0003436_decreased_susceptibility_to4.18894297
6MP0004019_abnormal_vitamin_homeostasis3.68962768
7MP0005085_abnormal_gallbladder_physiolo3.68950132
8MP0003303_peritoneal_inflammation3.57159545
9MP0005332_abnormal_amino_acid3.43092090
10MP0008875_abnormal_xenobiotic_pharmacok3.41040992
11MP0002419_abnormal_innate_immunity3.20575327
12MP0005365_abnormal_bile_salt3.18004356
13MP0009785_altered_susceptibility_to3.12309430
14MP0003195_calcinosis3.12077340
15MP0009643_abnormal_urine_homeostasis3.01602624
16MP0001835_abnormal_antigen_presentation2.96628244
17MP0006082_CNS_inflammation2.92896724
18MP0003252_abnormal_bile_duct2.82343036
19MP0002138_abnormal_hepatobiliary_system2.80719122
20MP0005025_abnormal_response_to2.77453144
21MP0001666_abnormal_nutrient_absorption2.76025763
22MP0003283_abnormal_digestive_organ2.75611887
23MP0008260_abnormal_autophagy2.60117615
24MP0005387_immune_system_phenotype2.56130824
25MP0001790_abnormal_immune_system2.56130824
26MP0002148_abnormal_hypersensitivity_rea2.55575628
27MP0001765_abnormal_ion_homeostasis2.54669550
28MP0005636_abnormal_mineral_homeostasis2.49741994
29MP0000685_abnormal_immune_system2.45952638
30MP0005000_abnormal_immune_tolerance2.45193822
31MP0001756_abnormal_urination2.43255728
32MP0005464_abnormal_platelet_physiology2.36748074
33MP0001800_abnormal_humoral_immune2.33605624
34MP0002723_abnormal_immune_serum2.28133374
35MP0010234_abnormal_vibrissa_follicle2.25333141
36MP0002452_abnormal_antigen_presenting2.25013984
37MP0002420_abnormal_adaptive_immunity2.21486031
38MP0001819_abnormal_immune_cell2.19842445
39MP0001533_abnormal_skeleton_physiology2.15692165
40MP0002132_abnormal_respiratory_system2.15315653
41MP0003828_pulmonary_edema2.13249656
42MP0000538_abnormal_urinary_bladder2.11809307
43MP0005671_abnormal_response_to2.11399277
44MP0003806_abnormal_nucleotide_metabolis2.04764514
45MP0009278_abnormal_bone_marrow2.03749564
46MP0005084_abnormal_gallbladder_morpholo1.96539594
47MP0000462_abnormal_digestive_system1.91729665
48MP0002405_respiratory_system_inflammati1.82205237
49MP0001845_abnormal_inflammatory_respons1.75908717
50MP0010386_abnormal_urinary_bladder1.75712715
51MP0003300_gastrointestinal_ulcer1.74859066
52MP0004947_skin_inflammation1.74765499
53MP0009840_abnormal_foam_cell1.71652100
54MP0002136_abnormal_kidney_physiology1.70751983
55MP0010155_abnormal_intestine_physiology1.66780476
56MP0003075_altered_response_to1.64582574
57MP0005377_hearing/vestibular/ear_phenot1.64389150
58MP0003878_abnormal_ear_physiology1.64389150
59MP0010329_abnormal_lipoprotein_level1.63887419
60MP0005083_abnormal_biliary_tract1.63532505
61MP0009333_abnormal_splenocyte_physiolog1.59697902
62MP0000858_altered_metastatic_potential1.59665021
63MP0001851_eye_inflammation1.59355043
64MP0004883_abnormal_blood_vessel1.56989441
65MP0000716_abnormal_immune_system1.55898709
66MP0008469_abnormal_protein_level1.55224039
67MP0002398_abnormal_bone_marrow1.54013344
68MP0005164_abnormal_response_to1.52545841
69MP0003172_abnormal_lysosome_physiology1.51755383
70MP0009764_decreased_sensitivity_to1.51295693
71MP0002277_abnormal_respiratory_mucosa1.50750955
72MP0004264_abnormal_extraembryonic_tissu1.49649647
73MP0001545_abnormal_hematopoietic_system1.43119921
74MP0005397_hematopoietic_system_phenotyp1.43119921
75MP0000343_altered_response_to1.42238182
76MP0003183_abnormal_peptide_metabolism1.39789327
77MP0004510_myositis1.38889144
78MP0000465_gastrointestinal_hemorrhage1.37617744
79MP0003763_abnormal_thymus_physiology1.34517144
80MP0008961_abnormal_basal_metabolism1.31720477
81MP0002822_catalepsy1.29035141
82MP0002722_abnormal_immune_system1.27603700
83MP0005166_decreased_susceptibility_to1.27238438
84MP0000689_abnormal_spleen_morphology1.26994822
85MP0002429_abnormal_blood_cell1.26244264
86MP0002998_abnormal_bone_remodeling1.24041065
87MP0002118_abnormal_lipid_homeostasis1.22257976
88MP0002735_abnormal_chemical_nociception1.21892924
89MP0005584_abnormal_enzyme/coenzyme_acti1.19267541
90MP0002876_abnormal_thyroid_physiology1.18304616
91MP0006036_abnormal_mitochondrial_physio1.13242338
92MP0003186_abnormal_redox_activity1.12874330
93MP0001664_abnormal_digestion1.11689155
94MP0005319_abnormal_enzyme/_coenzyme1.11404197
95MP0002396_abnormal_hematopoietic_system1.11118573
96MP0005058_abnormal_lysosome_morphology1.10810924
97MP0001853_heart_inflammation1.09583517
98MP0005381_digestive/alimentary_phenotyp1.08767520
99MP0005310_abnormal_salivary_gland1.07585581
100MP0005220_abnormal_exocrine_pancreas1.07410508
101MP0000230_abnormal_systemic_arterial1.07103498
102MP0009379_abnormal_foot_pigmentation1.06183521
103MP0004381_abnormal_hair_follicle1.06160373
104MP0005408_hypopigmentation1.06011870
105MP0008872_abnormal_physiological_respon1.04684521
106MP0002928_abnormal_bile_duct1.04045611
107MP0002837_dystrophic_cardiac_calcinosis1.03680408
108MP0009780_abnormal_chondrocyte_physiolo1.03248206
109MP0001663_abnormal_digestive_system1.03100566
110MP0003566_abnormal_cell_adhesion1.01704314
111MP0003453_abnormal_keratinocyte_physiol1.01278619
112MP0001764_abnormal_homeostasis1.00666634
113MP0005023_abnormal_wound_healing1.00452435
114MP0002078_abnormal_glucose_homeostasis0.98522533
115MP0004147_increased_porphyrin_level0.97853286
116MP0003191_abnormal_cellular_cholesterol0.97616680
117MP0003866_abnormal_defecation0.97248540
118MP0001944_abnormal_pancreas_morphology0.96955547
119MP0000678_abnormal_parathyroid_gland0.95543282
120MP0004270_analgesia0.95470261
121MP0000490_abnormal_crypts_of0.95389320
122MP0005535_abnormal_body_temperature0.94528484
123MP0000703_abnormal_thymus_morphology0.94500775
124MP0005379_endocrine/exocrine_gland_phen0.94080644
125MP0009763_increased_sensitivity_to0.93586198
126MP0004858_abnormal_nervous_system0.91802732
127MP0004885_abnormal_endolymph0.91585082
128MP0003879_abnormal_hair_cell0.90304952
129MP0000609_abnormal_liver_physiology0.89947736
130MP0003448_altered_tumor_morphology0.89162886
131MP0005390_skeleton_phenotype0.88495820
132MP0002896_abnormal_bone_mineralization0.86826615
133MP0002163_abnormal_gland_morphology0.84697825
134MP0003705_abnormal_hypodermis_morpholog0.84114275
135MP0003656_abnormal_erythrocyte_physiolo0.83833402
136MP0005451_abnormal_body_composition0.82991403
137MP0003953_abnormal_hormone_level0.82798399
138MP0001485_abnormal_pinna_reflex0.82422365
139MP0009642_abnormal_blood_homeostasis0.81408600
140MP0002332_abnormal_exercise_endurance0.80949968
141MP0001270_distended_abdomen0.79485511
142MP0006276_abnormal_autonomic_nervous0.78732168
143MP0008874_decreased_physiological_sensi0.77430834
144MP0003690_abnormal_glial_cell0.74467594
145MP0003315_abnormal_perineum_morphology0.74044170
146MP0003091_abnormal_cell_migration0.73351844
147MP0003868_abnormal_feces_composition0.72836510
148MP0000249_abnormal_blood_vessel0.72130650
149MP0002693_abnormal_pancreas_physiology0.71938883
150MP0002089_abnormal_postnatal_growth/wei0.71933917
151MP0003795_abnormal_bone_structure0.70634294
152MP0002736_abnormal_nociception_after0.69438624
153MP0002734_abnormal_mechanical_nocicepti0.68092081
154MP0003045_fibrosis0.67769581
155MP0009053_abnormal_anal_canal0.66844170
156MP0001873_stomach_inflammation0.66240982
157MP0008004_abnormal_stomach_pH0.64759424
158MP0002733_abnormal_thermal_nociception0.63775247
159MP0003638_abnormal_response/metabolism_0.62979898
160MP0003959_abnormal_lean_body0.59807544
161MP0005448_abnormal_energy_balance0.59273980
162MP0005376_homeostasis/metabolism_phenot0.58777362
163MP0009765_abnormal_xenobiotic_induced0.58210257
164MP0004808_abnormal_hematopoietic_stem0.57717379
165MP0002796_impaired_skin_barrier0.55974423
166MP0001968_abnormal_touch/_nociception0.55508236
167MP0001958_emphysema0.54851579
168MP0002933_joint_inflammation0.54803652
169MP0000013_abnormal_adipose_tissue0.54483636
170MP0002135_abnormal_kidney_morphology0.54094297
171MP0000477_abnormal_intestine_morphology0.52614104
172MP0002168_other_aberrant_phenotype0.52106694
173MP0005395_other_phenotype0.51170102
174MP0001986_abnormal_taste_sensitivity0.50614495
175MP0009697_abnormal_copulation0.48246269
176MP0006035_abnormal_mitochondrial_morpho0.48010683
177MP0000613_abnormal_salivary_gland0.47658810
178MP0000537_abnormal_urethra_morphology0.45821719

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.58854879
2Abnormality of macrophages (HP:0004311)6.07058136
3Recurrent abscess formation (HP:0002722)6.01141176
4Recurrent bacterial skin infections (HP:0005406)5.84101796
5Hyperactive renin-angiotensin system (HP:0000841)5.56735049
6Myositis (HP:0100614)5.45413708
7Gout (HP:0001997)5.19756203
8Abnormality of chloride homeostasis (HP:0011422)5.17539136
9Orchitis (HP:0100796)5.14698326
10Recurrent gram-negative bacterial infections (HP:0005420)5.07069382
11Hypokalemic alkalosis (HP:0001949)4.86360409
12Metabolic alkalosis (HP:0200114)4.82553125
13Hypochromic microcytic anemia (HP:0004840)4.79029242
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.77308725
15Stomatitis (HP:0010280)4.72654842
16Retrobulbar optic neuritis (HP:0100654)4.58579566
17Optic neuritis (HP:0100653)4.58579566
18Increased circulating renin level (HP:0000848)4.57929897
19Elevated erythrocyte sedimentation rate (HP:0003565)4.22487501
20Hypomagnesemia (HP:0002917)4.22405852
21Proximal tubulopathy (HP:0000114)4.14927763
22Hyperglycinuria (HP:0003108)4.10498167
23Chronic obstructive pulmonary disease (HP:0006510)4.10120586
24Obstructive lung disease (HP:0006536)4.10120586
25Abnormality of magnesium homeostasis (HP:0004921)4.02499387
26Glycosuria (HP:0003076)4.02316865
27Abnormality of urine glucose concentration (HP:0011016)4.02316865
28Mediastinal lymphadenopathy (HP:0100721)4.01050402
29Abnormality of aromatic amino acid family metabolism (HP:0004338)3.99857881
30Alkalosis (HP:0001948)3.99738207
31Abnormal urine output (HP:0012590)3.97109095
32Polyuria (HP:0000103)3.94820941
33Abnormality of purine metabolism (HP:0004352)3.90511974
34Hyperphosphaturia (HP:0003109)3.83603954
35Increased purine levels (HP:0004368)3.79863142
36Hyperuricemia (HP:0002149)3.79863142
37Urticaria (HP:0001025)3.78775794
38Abnormality of renal excretion (HP:0011036)3.77648919
39Abnormality of renin-angiotensin system (HP:0000847)3.72622048
40Generalized aminoaciduria (HP:0002909)3.66550070
41Hypochromic anemia (HP:0001931)3.63976399
42Ketoacidosis (HP:0001993)3.63153497
43Increased IgE level (HP:0003212)3.54510060
44Recurrent skin infections (HP:0001581)3.54162832
45Ileus (HP:0002595)3.52423006
46Amyloidosis (HP:0011034)3.51667598
47Keratoconjunctivitis sicca (HP:0001097)3.45899618
48Petechiae (HP:0000967)3.44819940
49Hyperaldosteronism (HP:0000859)3.44295816
50Gingivitis (HP:0000230)3.42622979
51Prolonged bleeding time (HP:0003010)3.39623337
52Gastrointestinal infarctions (HP:0005244)3.39109670
53Recurrent fungal infections (HP:0002841)3.38288829
54Meningitis (HP:0001287)3.37117692
55Abnormal urine phosphate concentration (HP:0012599)3.36723179
56Abnormal delayed hypersensitivity skin test (HP:0002963)3.25935006
57Abnormality of glycine metabolism (HP:0010895)3.25748985
58Abnormality of serine family amino acid metabolism (HP:0010894)3.25748985
59Episodic fever (HP:0001954)3.21522908
60Renal salt wasting (HP:0000127)3.15026602
61Keratoconjunctivitis (HP:0001096)3.13991399
62Encephalitis (HP:0002383)3.11926181
63Spontaneous hematomas (HP:0007420)3.11881754
64Pustule (HP:0200039)3.09657292
65Malnutrition (HP:0004395)3.09467831
66Ketosis (HP:0001946)3.08871288
67Hypokalemia (HP:0002900)3.06995823
68Hydroxyprolinuria (HP:0003080)3.06707585
69Abnormality of proline metabolism (HP:0010907)3.06707585
70Hypoglycemic coma (HP:0001325)3.05821700
71Abnormality of liposaccharide metabolism (HP:0010968)3.01834316
72Abnormality of glycosphingolipid metabolism (HP:0004343)3.01834316
73Abnormality of glycolipid metabolism (HP:0010969)3.01834316
74Abnormality of nucleobase metabolism (HP:0010932)2.98847801
75Vasculitis (HP:0002633)2.94082667
76Gingival bleeding (HP:0000225)2.93957478
77Polydipsia (HP:0001959)2.92569074
78Abnormal drinking behavior (HP:0030082)2.92569074
79Acute encephalopathy (HP:0006846)2.90246746
80Anorexia (HP:0002039)2.88582479
81Hepatosplenomegaly (HP:0001433)2.85769436
82Cellulitis (HP:0100658)2.82902890
83Purpura (HP:0000979)2.82158536
84Late onset (HP:0003584)2.78290722
85Epistaxis (HP:0000421)2.77837700
86Abnormal tarsal ossification (HP:0008369)2.77160120
87Hypercalciuria (HP:0002150)2.75522502
88Tetany (HP:0001281)2.74282924
89Hypophosphatemia (HP:0002148)2.72969721
90Hyperglycinemia (HP:0002154)2.69903668
91Nephrolithiasis (HP:0000787)2.69033205
92Abnormality of dicarboxylic acid metabolism (HP:0010995)2.67368053
93Dicarboxylic aciduria (HP:0003215)2.67368053
94Conjugated hyperbilirubinemia (HP:0002908)2.64272870
95Loss of speech (HP:0002371)2.63002700
96Microcytic anemia (HP:0001935)2.60848679
97Recurrent cutaneous fungal infections (HP:0011370)2.60650608
98Chronic mucocutaneous candidiasis (HP:0002728)2.60650608
99Metabolic acidosis (HP:0001942)2.58738543
100Hyperammonemia (HP:0001987)2.58401791
101Abnormality of aspartate family amino acid metabolism (HP:0010899)2.58112744
102Pulmonary infiltrates (HP:0002113)2.56737153
103Increased serum ferritin (HP:0003281)2.56629433
104Increased IgM level (HP:0003496)2.56433496
105Vacuolated lymphocytes (HP:0001922)2.56063112
106Chest pain (HP:0100749)2.55291493
107Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54361340
108Abnormality of fatty-acid metabolism (HP:0004359)2.53712078
109Lethargy (HP:0001254)2.53568730
110Abnormality of the heme biosynthetic pathway (HP:0010472)2.50708677
111Xanthomatosis (HP:0000991)2.50546948
112Renal tubular acidosis (HP:0001947)2.50180197
113Abnormal platelet volume (HP:0011876)2.49917420
114Peritonitis (HP:0002586)2.48196578
115Delayed epiphyseal ossification (HP:0002663)2.47741739
116Osteomyelitis (HP:0002754)2.43271170
117Hepatic necrosis (HP:0002605)2.42509146
118Dehydration (HP:0001944)2.42449496
119Hemoptysis (HP:0002105)2.42069311
120Decreased circulating renin level (HP:0003351)2.41758112
121Abnormality of renal resorption (HP:0011038)2.39649776
122Vomiting (HP:0002013)2.39424855
123Abnormality of potassium homeostasis (HP:0011042)2.39065661
124Symptomatic seizures (HP:0011145)2.38678068
125Abnormality of iron homeostasis (HP:0011031)2.37948905
126Widely patent fontanelles and sutures (HP:0004492)2.35721227
127Potter facies (HP:0002009)2.34458022
128Facial shape deformation (HP:0011334)2.34458022
129Arterial thrombosis (HP:0004420)2.33273640
130Intrahepatic cholestasis (HP:0001406)2.32159960
131Inflammation of the large intestine (HP:0002037)2.31559306
132Premature loss of primary teeth (HP:0006323)2.30455290
133Abnormal hemoglobin (HP:0011902)2.30121162
134Rickets (HP:0002748)2.27738331
135Gastrointestinal inflammation (HP:0004386)2.25945795
136Gangrene (HP:0100758)2.25097041
137Cerebral edema (HP:0002181)2.24251179
138Abnormality of the pericardium (HP:0001697)2.23860783
139Abnormal mitochondria in muscle tissue (HP:0008316)2.23178957
140Acute necrotizing encephalopathy (HP:0006965)2.21994386
141Pulmonary embolism (HP:0002204)2.21986330
142Increased cerebral lipofuscin (HP:0011813)2.21272305
143Skin ulcer (HP:0200042)2.20848989
144Toxemia of pregnancy (HP:0100603)2.20726232
145Adrenal overactivity (HP:0002717)2.20092442
146Polycythemia (HP:0001901)2.20030442
147Hypoglycemic seizures (HP:0002173)2.18684824
148Hypergammaglobulinemia (HP:0010702)2.15880714
149Leukocytosis (HP:0001974)2.15227487
150Renal tubular dysfunction (HP:0000124)2.14636239
151Mitochondrial inheritance (HP:0001427)2.14239435
152Irritability (HP:0000737)2.13973098
153Granulocytopenia (HP:0001913)2.13144630
154Abnormality of calcium-phosphate metabolism (HP:0100530)2.12994294
155Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.12412216
156Abnormality of sulfur amino acid metabolism (HP:0004339)2.11415621
157Methylmalonic aciduria (HP:0012120)2.08177074
158Sepsis (HP:0100806)2.07814084
159Hyperinsulinemic hypoglycemia (HP:0000825)2.07461878
160Thin bony cortex (HP:0002753)2.05956965
161Glomerulopathy (HP:0100820)2.05166251
162Segmental peripheral demyelination/remyelination (HP:0003481)2.02970577
163Systemic lupus erythematosus (HP:0002725)2.01364636
164Cheilitis (HP:0100825)2.00307116
165Hepatocellular necrosis (HP:0001404)2.00286400
166Flat acetabular roof (HP:0003180)2.00127632
167Acne (HP:0001061)1.99686064
168Abnormal enzyme/coenzyme activity (HP:0012379)1.98495567
169Muscle fiber splitting (HP:0003555)1.98296109
170Vascular calcification (HP:0004934)1.97455704
171Abnormality of carpal bone ossification (HP:0006257)1.97308254
172Abdominal distention (HP:0003270)1.96829834
173Abnormality of alkaline phosphatase activity (HP:0004379)1.93994492
174Hypotension (HP:0002615)1.93585229
175Abnormality of the pleura (HP:0002103)1.93022638
176Abnormality of T cell physiology (HP:0011840)1.92804595
177Progressive neurologic deterioration (HP:0002344)1.92075808
178Skin rash (HP:0000988)1.91233080
179Hypobetalipoproteinemia (HP:0003563)1.90836947
180Enlarged kidneys (HP:0000105)1.90818903
181Abnormality of T cells (HP:0002843)1.89052161
182Recurrent viral infections (HP:0004429)1.88946497
183Pheochromocytoma (HP:0002666)1.88026271
184Hyperparathyroidism (HP:0000843)1.87762202
185Disinhibition (HP:0000734)1.86749927
186Abnormality of T cell number (HP:0011839)1.86557610
187Abnormality of transition element cation homeostasis (HP:0011030)1.85960345
188Impaired platelet aggregation (HP:0003540)1.85812526
189Abnormal platelet function (HP:0011869)1.85812526
190Menorrhagia (HP:0000132)1.83938616
191Increased neuronal autofluorescent lipopigment (HP:0002074)1.82527204
192Hypermelanotic macule (HP:0001034)1.82437219
193Lymphopenia (HP:0001888)1.78980265
194Axonal loss (HP:0003447)1.78681502
195T lymphocytopenia (HP:0005403)1.78636119
196Splenomegaly (HP:0001744)1.78533777
197Dysostosis multiplex (HP:0000943)1.77774074

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.89543473
2LMTK25.33151948
3RIPK44.66443221
4TAOK34.56122167
5WNK34.49820681
6OXSR13.90538423
7MAP2K33.43914447
8IRAK43.38861741
9FRK3.08085312
10BLK2.86089450
11STK392.84733881
12MAP4K12.77390448
13MAP3K22.68560264
14CSK2.56573377
15TYK22.47190284
16SIK32.46509246
17NME12.37128934
18PRKG22.32949282
19BCKDK2.18446768
20TNK22.17996832
21ZAP702.14987681
22PRPF4B2.02555620
23FES2.01561932
24EPHB22.01026332
25INSRR1.95843199
26FGR1.82984201
27MST1R1.82695412
28MAPK151.81873842
29STK38L1.75419965
30MAP2K21.71942527
31HCK1.62660852
32ERN11.50931108
33MST41.50154019
34BTK1.47913386
35TAOK21.47151964
36MAP3K131.46628531
37TESK21.45039138
38TBK11.43484835
39JAK31.34763545
40SGK2231.33522454
41SGK4941.33522454
42STK101.31670049
43WNK11.27514890
44CSF1R1.24585860
45SYK1.21116771
46FER1.20402884
47PTK21.19084686
48LYN1.15959479
49YES11.15083344
50JAK21.14105651
51MAP3K141.13498254
52RIPK11.12211234
53PAK41.11971706
54IRAK31.11591085
55IKBKE1.08160532
56GRK51.07709295
57NEK11.07217334
58TESK11.06478583
59TGFBR21.05621033
60MAP3K61.04960091
61FGFR41.03691096
62EPHA21.02570719
63ARAF1.01389710
64TXK0.99472550
65MAP3K30.97937136
66SCYL20.96516599
67PRKD20.95765129
68LIMK10.94235344
69GRK60.93945712
70MAP3K120.93325593
71SIK10.92661841
72MAP2K10.89498625
73LCK0.89052612
74PTK60.88697412
75MARK30.88310128
76KSR20.88239041
77IKBKB0.84673728
78SMG10.83030984
79PDK40.81827032
80PDK30.81827032
81BMPR20.81649678
82KSR10.81535732
83PRKCI0.81426666
84NTRK10.81070508
85IRAK20.80223229
86PDK10.78487638
87PTK2B0.77663389
88PDK20.77528540
89PASK0.76895523
90JAK10.76847818
91MOS0.74912099
92CDK190.74567050
93BMX0.72864662
94MARK20.72555925
95EPHA30.72203718
96RAF10.71801159
97MYLK0.71701383
98AKT30.69571594
99PRKD30.69389933
100NME20.68592643
101NTRK30.65944405
102MAP3K80.64849257
103MAP3K50.64366045
104BRAF0.63550193
105MAPKAPK20.63468198
106MAP2K60.62064832
107FYN0.61603013
108IRAK10.61300043
109PIK3CA0.59402212
110MAPKAPK30.58716588
111TEC0.56902159
112LATS20.55963613
113SGK20.55480743
114ITK0.54199686
115MINK10.53796726
116SIK20.52355933
117SGK30.51934137
118EPHB10.51488909
119MAP3K10.51165218
120MET0.48428488
121MAP3K90.48249921
122MAP3K110.47877895
123TIE10.47580283
124PAK30.47003616
125KIT0.46275859
126MAPK120.45340914
127GSK3A0.44218729
128PRKAA10.43830422
129ABL20.43521444
130PIM20.43265205
131STK240.41786383
132PRKCQ0.41699358
133NEK90.41085995
134HIPK20.40110328
135MAPK70.39737137
136ERBB20.39581167
137RET0.38188880
138PDPK10.38147221
139CAMK2G0.37798585
140PIK3CG0.37792285
141ADRBK10.37508801
142LRRK20.37424379
143PRKACG0.37284504
144MAPK110.36894327
145STK380.35370107
146ERBB40.35195409
147PRKCD0.35024164
148TAOK10.34123731
149RPS6KA20.34054138
150PRKCA0.32035709
151GRK70.30733414
152CAMK2D0.30603833
153STK110.30460954
154PRKAA20.28814524
155MATK0.27801142
156MAP2K40.27503766
157PRKCE0.27230284
158PRKACA0.26908255
159CDC42BPA0.25065937
160BRSK20.23792391
161EIF2AK10.23452627
162DAPK20.22008617
163PRKCZ0.21329022
164TRIB30.20588721
165ROCK10.18992711

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.22367153
2Sulfur metabolism_Homo sapiens_hsa009203.20878744
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.08825133
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90314412
5Leishmaniasis_Homo sapiens_hsa051402.89513982
6Staphylococcus aureus infection_Homo sapiens_hsa051502.85940138
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.83577962
8Butanoate metabolism_Homo sapiens_hsa006502.81588456
9Oxidative phosphorylation_Homo sapiens_hsa001902.52010897
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49285756
11Malaria_Homo sapiens_hsa051442.41894579
12Tryptophan metabolism_Homo sapiens_hsa003802.39826588
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.32080585
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30081326
15Tuberculosis_Homo sapiens_hsa051522.30004705
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.25808513
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.16597847
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.14836893
19Toll-like receptor signaling pathway_Homo sapiens_hsa046202.14762600
20NOD-like receptor signaling pathway_Homo sapiens_hsa046212.13170907
21Legionellosis_Homo sapiens_hsa051342.12130583
22Cyanoamino acid metabolism_Homo sapiens_hsa004602.03370664
23Propanoate metabolism_Homo sapiens_hsa006402.01141766
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00332798
25Vitamin digestion and absorption_Homo sapiens_hsa049771.99235739
26Fatty acid degradation_Homo sapiens_hsa000711.98983623
27Parkinsons disease_Homo sapiens_hsa050121.98831628
28Folate biosynthesis_Homo sapiens_hsa007901.95542564
29Bile secretion_Homo sapiens_hsa049761.92924181
30Pyruvate metabolism_Homo sapiens_hsa006201.90236839
31B cell receptor signaling pathway_Homo sapiens_hsa046621.87067421
32Graft-versus-host disease_Homo sapiens_hsa053321.86455904
33African trypanosomiasis_Homo sapiens_hsa051431.84718517
34Peroxisome_Homo sapiens_hsa041461.83639534
35Mineral absorption_Homo sapiens_hsa049781.80715729
36Fat digestion and absorption_Homo sapiens_hsa049751.70095430
37Chemokine signaling pathway_Homo sapiens_hsa040621.68815779
38Allograft rejection_Homo sapiens_hsa053301.68780553
39Histidine metabolism_Homo sapiens_hsa003401.66102827
40Starch and sucrose metabolism_Homo sapiens_hsa005001.64957049
41Hematopoietic cell lineage_Homo sapiens_hsa046401.64778852
42Phagosome_Homo sapiens_hsa041451.62410664
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59057205
44Acute myeloid leukemia_Homo sapiens_hsa052211.58957133
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58226028
46Salmonella infection_Homo sapiens_hsa051321.55689454
47Measles_Homo sapiens_hsa051621.52268073
48Autoimmune thyroid disease_Homo sapiens_hsa053201.50953795
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.47883220
50Shigellosis_Homo sapiens_hsa051311.47878392
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47562058
52Glutathione metabolism_Homo sapiens_hsa004801.47147841
53TNF signaling pathway_Homo sapiens_hsa046681.45924675
54Collecting duct acid secretion_Homo sapiens_hsa049661.45386939
55Toxoplasmosis_Homo sapiens_hsa051451.44955015
56Alzheimers disease_Homo sapiens_hsa050101.44762130
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44563880
58Influenza A_Homo sapiens_hsa051641.42245211
59Fructose and mannose metabolism_Homo sapiens_hsa000511.42110893
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.41578085
61Primary bile acid biosynthesis_Homo sapiens_hsa001201.41284765
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38631675
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36248125
64Pertussis_Homo sapiens_hsa051331.35962820
65Arginine biosynthesis_Homo sapiens_hsa002201.34427068
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33628807
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.33352002
68Arginine and proline metabolism_Homo sapiens_hsa003301.32528084
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.29610548
70Carbon metabolism_Homo sapiens_hsa012001.27019014
71beta-Alanine metabolism_Homo sapiens_hsa004101.26948588
72Renin-angiotensin system_Homo sapiens_hsa046141.26908267
73Phenylalanine metabolism_Homo sapiens_hsa003601.26132306
74Pancreatic cancer_Homo sapiens_hsa052121.26073067
75Viral myocarditis_Homo sapiens_hsa054161.25703342
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25415058
77Antigen processing and presentation_Homo sapiens_hsa046121.25224773
78Fatty acid metabolism_Homo sapiens_hsa012121.20280284
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20078702
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20035541
81PPAR signaling pathway_Homo sapiens_hsa033201.19481773
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19376315
83Primary immunodeficiency_Homo sapiens_hsa053401.18247981
84Non-small cell lung cancer_Homo sapiens_hsa052231.16794787
85Huntingtons disease_Homo sapiens_hsa050161.16333678
86Herpes simplex infection_Homo sapiens_hsa051681.15253632
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14672744
88Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14621894
89Protein digestion and absorption_Homo sapiens_hsa049741.14279377
90T cell receptor signaling pathway_Homo sapiens_hsa046601.13856251
91Rheumatoid arthritis_Homo sapiens_hsa053231.12765004
92Galactose metabolism_Homo sapiens_hsa000521.12059569
93SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09867256
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07886711
95Vibrio cholerae infection_Homo sapiens_hsa051101.07842485
96Chemical carcinogenesis_Homo sapiens_hsa052041.07622683
97Renal cell carcinoma_Homo sapiens_hsa052111.06417659
98Selenocompound metabolism_Homo sapiens_hsa004501.06277493
99Platelet activation_Homo sapiens_hsa046111.05971899
100Hepatitis C_Homo sapiens_hsa051601.04142883
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03009991
102Type I diabetes mellitus_Homo sapiens_hsa049401.02606495
103Hepatitis B_Homo sapiens_hsa051611.02427422
104Jak-STAT signaling pathway_Homo sapiens_hsa046301.02365578
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00590037
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00117370
107Endocytosis_Homo sapiens_hsa041440.99984674
108Apoptosis_Homo sapiens_hsa042100.99933688
109Protein export_Homo sapiens_hsa030600.99859860
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98118406
111Nitrogen metabolism_Homo sapiens_hsa009100.95637476
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95294979
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94791081
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93126477
115Amoebiasis_Homo sapiens_hsa051460.92369426
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.90016924
117Tyrosine metabolism_Homo sapiens_hsa003500.89731537
118Chronic myeloid leukemia_Homo sapiens_hsa052200.88136919
119Glycerolipid metabolism_Homo sapiens_hsa005610.86307383
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84231484
121VEGF signaling pathway_Homo sapiens_hsa043700.79119456
122Pentose phosphate pathway_Homo sapiens_hsa000300.78560547
123Cardiac muscle contraction_Homo sapiens_hsa042600.77413191
124Steroid biosynthesis_Homo sapiens_hsa001000.75422696
125Fatty acid elongation_Homo sapiens_hsa000620.73909315
126* Metabolic pathways_Homo sapiens_hsa011000.71957182
127Other glycan degradation_Homo sapiens_hsa005110.71914991
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70923356
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.69467027
130Asthma_Homo sapiens_hsa053100.68526623
131Thyroid hormone synthesis_Homo sapiens_hsa049180.65248850
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63792137
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.63112543
134* Drug metabolism - other enzymes_Homo sapiens_hsa009830.62880400
135HIF-1 signaling pathway_Homo sapiens_hsa040660.62071120
136Retinol metabolism_Homo sapiens_hsa008300.62001305
137Biosynthesis of amino acids_Homo sapiens_hsa012300.61351003
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61263738
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57892554
140ABC transporters_Homo sapiens_hsa020100.57135841
141Caffeine metabolism_Homo sapiens_hsa002320.56921928
142Epstein-Barr virus infection_Homo sapiens_hsa051690.56221653
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55594774
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55204311
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54391551
146Insulin secretion_Homo sapiens_hsa049110.52563261
147FoxO signaling pathway_Homo sapiens_hsa040680.51570871
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.49659396
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49608100
150Viral carcinogenesis_Homo sapiens_hsa052030.48594279
151Sulfur relay system_Homo sapiens_hsa041220.47984364
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.47728955
153Adipocytokine signaling pathway_Homo sapiens_hsa049200.45920648
154Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45655946
155Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45562052
156Notch signaling pathway_Homo sapiens_hsa043300.44947987
157Regulation of autophagy_Homo sapiens_hsa041400.44842592
158Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44563846
159Lysine degradation_Homo sapiens_hsa003100.42941476
160Prolactin signaling pathway_Homo sapiens_hsa049170.42758140
161Insulin resistance_Homo sapiens_hsa049310.41125426
162Synaptic vesicle cycle_Homo sapiens_hsa047210.40967307
163Thyroid cancer_Homo sapiens_hsa052160.38826905
164ErbB signaling pathway_Homo sapiens_hsa040120.38277739
165Endometrial cancer_Homo sapiens_hsa052130.37332870
166Cysteine and methionine metabolism_Homo sapiens_hsa002700.35774412
167Sphingolipid metabolism_Homo sapiens_hsa006000.34672741
168GnRH signaling pathway_Homo sapiens_hsa049120.34014608
169HTLV-I infection_Homo sapiens_hsa051660.34008454
170Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33992082
171Arachidonic acid metabolism_Homo sapiens_hsa005900.33207600
172Choline metabolism in cancer_Homo sapiens_hsa052310.32964650
173Rap1 signaling pathway_Homo sapiens_hsa040150.32638726
174alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27049295
175Lysosome_Homo sapiens_hsa041420.24426789
176Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22084447
177Gastric acid secretion_Homo sapiens_hsa049710.20451521
178Pancreatic secretion_Homo sapiens_hsa049720.19259854
179Bladder cancer_Homo sapiens_hsa052190.17173332
180Glycosaminoglycan degradation_Homo sapiens_hsa005310.15224855
181Complement and coagulation cascades_Homo sapiens_hsa046100.14784189
182Glycerophospholipid metabolism_Homo sapiens_hsa005640.13167964
183Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.09739775

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