CDADC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)8.13541028
2centriole assembly (GO:0098534)5.81210809
3L-phenylalanine catabolic process (GO:0006559)5.79904081
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.79904081
5L-phenylalanine metabolic process (GO:0006558)5.48917611
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.48917611
7aromatic amino acid family catabolic process (GO:0009074)5.45623842
8indole-containing compound catabolic process (GO:0042436)5.13124327
9indolalkylamine catabolic process (GO:0046218)5.13124327
10tryptophan catabolic process (GO:0006569)5.13124327
11chaperone-mediated protein transport (GO:0072321)4.99883874
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.86676689
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.79094558
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.79094558
15NADH dehydrogenase complex assembly (GO:0010257)4.79094558
16kynurenine metabolic process (GO:0070189)4.77919988
17bile acid biosynthetic process (GO:0006699)4.75819580
18tryptophan metabolic process (GO:0006568)4.72840790
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.71848361
20protein complex biogenesis (GO:0070271)4.70586879
21rRNA modification (GO:0000154)4.63272776
22alpha-linolenic acid metabolic process (GO:0036109)4.56718197
23response to pheromone (GO:0019236)4.53014425
24rRNA methylation (GO:0031167)4.50913405
25lysine catabolic process (GO:0006554)4.49043722
26lysine metabolic process (GO:0006553)4.49043722
27mitochondrial respiratory chain complex assembly (GO:0033108)4.38235642
28ATP synthesis coupled proton transport (GO:0015986)4.33349190
29energy coupled proton transport, down electrochemical gradient (GO:0015985)4.33349190
30respiratory chain complex IV assembly (GO:0008535)4.22304250
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.16309984
32sperm motility (GO:0030317)4.15745203
33glyoxylate metabolic process (GO:0046487)4.14777582
34oxaloacetate metabolic process (GO:0006107)4.14173319
35urea cycle (GO:0000050)4.12326553
36urea metabolic process (GO:0019627)4.12326553
37cysteine metabolic process (GO:0006534)4.11539258
38cellular ketone body metabolic process (GO:0046950)4.02062071
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.97594990
40epithelial cilium movement (GO:0003351)3.96219889
41bile acid metabolic process (GO:0008206)3.94120397
42sulfur amino acid catabolic process (GO:0000098)3.91525938
43high-density lipoprotein particle remodeling (GO:0034375)3.90391138
44protein polyglutamylation (GO:0018095)3.90311448
45alpha-amino acid catabolic process (GO:1901606)3.89245435
46aromatic amino acid family metabolic process (GO:0009072)3.84603470
47valine metabolic process (GO:0006573)3.79256700
48peptidyl-glutamic acid carboxylation (GO:0017187)3.78009413
49protein carboxylation (GO:0018214)3.78009413
50cytochrome complex assembly (GO:0017004)3.76964535
51complement activation, alternative pathway (GO:0006957)3.75505004
52respiratory electron transport chain (GO:0022904)3.71788525
53succinate metabolic process (GO:0006105)3.71269115
54dicarboxylic acid biosynthetic process (GO:0043650)3.70373016
55nitrogen cycle metabolic process (GO:0071941)3.67728942
56regulation of cilium movement (GO:0003352)3.67657519
57electron transport chain (GO:0022900)3.67172483
58homocysteine metabolic process (GO:0050667)3.67114398
59branched-chain amino acid catabolic process (GO:0009083)3.66942508
60amino-acid betaine metabolic process (GO:0006577)3.66654534
61coenzyme catabolic process (GO:0009109)3.65380725
62aldehyde catabolic process (GO:0046185)3.64629710
63cellular amino acid catabolic process (GO:0009063)3.62668745
64NADH metabolic process (GO:0006734)3.61446050
65amine catabolic process (GO:0009310)3.60408365
66cellular biogenic amine catabolic process (GO:0042402)3.60408365
67regulation of protein activation cascade (GO:2000257)3.58481933
68NAD metabolic process (GO:0019674)3.57774541
69single strand break repair (GO:0000012)3.54862122
70NAD biosynthetic process (GO:0009435)3.53657703
71indolalkylamine metabolic process (GO:0006586)3.52092776
72killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.48470600
73disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.48470600
74regulation of triglyceride catabolic process (GO:0010896)3.48160310
752-oxoglutarate metabolic process (GO:0006103)3.48130304
76fatty acid beta-oxidation (GO:0006635)3.47922809
77regulation of cholesterol esterification (GO:0010872)3.47906699
78short-chain fatty acid metabolic process (GO:0046459)3.46667518
79glutamate metabolic process (GO:0006536)3.45472494
80plasma lipoprotein particle remodeling (GO:0034369)3.43811993
81protein-lipid complex remodeling (GO:0034368)3.43811993
82macromolecular complex remodeling (GO:0034367)3.43811993
83aspartate family amino acid catabolic process (GO:0009068)3.43401657
84cellular glucuronidation (GO:0052695)3.41075139
85C-terminal protein lipidation (GO:0006501)3.40493833
86branched-chain amino acid metabolic process (GO:0009081)3.39448768
87ketone body metabolic process (GO:1902224)3.39179019
88axonemal dynein complex assembly (GO:0070286)3.38204295
89negative regulation of fibrinolysis (GO:0051918)3.38079227
90protein neddylation (GO:0045116)3.37964763
91parturition (GO:0007567)3.37305067
92serine family amino acid catabolic process (GO:0009071)3.36153177
93regulation of complement activation (GO:0030449)3.35788018
94imidazole-containing compound metabolic process (GO:0052803)3.35650791
95carboxylic acid catabolic process (GO:0046395)3.34933371
96organic acid catabolic process (GO:0016054)3.34933371
97low-density lipoprotein particle remodeling (GO:0034374)3.34726247
98tricarboxylic acid cycle (GO:0006099)3.34545693
99drug catabolic process (GO:0042737)3.32140244
100monocarboxylic acid catabolic process (GO:0072329)3.31950979
101GPI anchor metabolic process (GO:0006505)3.31195670
102acylglycerol homeostasis (GO:0055090)3.31049412
103triglyceride homeostasis (GO:0070328)3.31049412
104pyridine nucleotide biosynthetic process (GO:0019363)3.30241228
105nicotinamide nucleotide biosynthetic process (GO:0019359)3.30241228
106reverse cholesterol transport (GO:0043691)3.30051695
107benzene-containing compound metabolic process (GO:0042537)3.29822932
108tyrosine metabolic process (GO:0006570)3.28780663
109fatty acid catabolic process (GO:0009062)3.28593412
110glucuronate metabolic process (GO:0019585)3.27594157
111uronic acid metabolic process (GO:0006063)3.27594157
112acrosome reaction (GO:0007340)3.26986093
113male meiosis I (GO:0007141)3.26764575
114fatty acid oxidation (GO:0019395)3.26342757
115preassembly of GPI anchor in ER membrane (GO:0016254)3.24122205
116lipid oxidation (GO:0034440)3.21714643
117cofactor catabolic process (GO:0051187)3.20311387
118ubiquinone biosynthetic process (GO:0006744)3.17139995
119ribosomal small subunit assembly (GO:0000028)3.17069337
120ribosomal small subunit biogenesis (GO:0042274)3.14600112
121establishment of protein localization to mitochondrial membrane (GO:0090151)3.13559088
122bile acid and bile salt transport (GO:0015721)3.12404555
123C-terminal protein amino acid modification (GO:0018410)3.11962479
124behavioral response to ethanol (GO:0048149)3.11004445
125axoneme assembly (GO:0035082)3.10566897
126regulation of fibrinolysis (GO:0051917)3.10059579
127peroxisome fission (GO:0016559)3.07917509
128DNA deamination (GO:0045006)3.06716659
129phospholipid efflux (GO:0033700)3.06229364
130exogenous drug catabolic process (GO:0042738)3.04784288
131drug transmembrane transport (GO:0006855)3.04133986
132cilium movement (GO:0003341)3.02571561
133cholesterol efflux (GO:0033344)3.02058115
134nonmotile primary cilium assembly (GO:0035058)3.00798316
135cellular modified amino acid catabolic process (GO:0042219)2.99389069
136indole-containing compound metabolic process (GO:0042430)2.99335769
137ribosomal large subunit biogenesis (GO:0042273)2.99075240
138spermatid development (GO:0007286)2.98871004
139spermatid nucleus differentiation (GO:0007289)2.98455276
140carnitine metabolic process (GO:0009437)2.97858967
141arginine metabolic process (GO:0006525)2.97143622
142intracellular protein transmembrane import (GO:0044743)2.96533584
143adenosine metabolic process (GO:0046085)2.96416524
144GPI anchor biosynthetic process (GO:0006506)2.95307812
145fructose metabolic process (GO:0006000)2.93979600
146mannosylation (GO:0097502)2.93635303
147killing of cells of other organism (GO:0031640)2.90879807
148disruption of cells of other organism (GO:0044364)2.90879807
149epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90588370
150dicarboxylic acid catabolic process (GO:0043649)2.89437800
151protein-cofactor linkage (GO:0018065)2.89003330
152cell wall macromolecule catabolic process (GO:0016998)2.87169125
153viral transcription (GO:0019083)2.86275679
154retinal rod cell development (GO:0046548)2.83939397
155seminiferous tubule development (GO:0072520)2.82235260
156translational termination (GO:0006415)2.80996294
157ubiquinone metabolic process (GO:0006743)2.76538167
158intraciliary transport (GO:0042073)2.75666540
159neurotransmitter catabolic process (GO:0042135)2.75459412
160replication fork processing (GO:0031297)2.70847945
161hydrogen ion transmembrane transport (GO:1902600)2.68217906
162cotranslational protein targeting to membrane (GO:0006613)2.68156305
163regulation of glucokinase activity (GO:0033131)2.67009408
164regulation of hexokinase activity (GO:1903299)2.67009408
165SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65415309
166positive regulation of mast cell activation involved in immune response (GO:0033008)2.64731336
167positive regulation of mast cell degranulation (GO:0043306)2.64731336
168nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64108710
169protein deneddylation (GO:0000338)2.64008922
170alanine transport (GO:0032328)2.62651914
171protein targeting to ER (GO:0045047)2.62503990
172meiosis I (GO:0007127)2.61166715
173tyrosine phosphorylation of STAT protein (GO:0007260)2.59668731
174deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.59304849
175cell wall macromolecule metabolic process (GO:0044036)2.58104084
176protein localization to endoplasmic reticulum (GO:0070972)2.57828539
177microtubule depolymerization (GO:0007019)2.56774971
178cilium organization (GO:0044782)2.56308986
179inner mitochondrial membrane organization (GO:0007007)2.56205828
180purine nucleoside triphosphate biosynthetic process (GO:0009145)2.55287902
181piRNA metabolic process (GO:0034587)2.53955672
182estrogen biosynthetic process (GO:0006703)2.53416599
183regulation of glucocorticoid secretion (GO:2000849)2.53109441
184protein localization to cilium (GO:0061512)2.52043544
185cilium assembly (GO:0042384)2.51852975
186proton transport (GO:0015992)2.50832551
187establishment of protein localization to endoplasmic reticulum (GO:0072599)2.48803540
188locomotory exploration behavior (GO:0035641)2.48054970
189protoporphyrinogen IX biosynthetic process (GO:0006782)2.47913589
190ATP biosynthetic process (GO:0006754)2.47796360
191purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.45856687
192hydrogen transport (GO:0006818)2.44362591
193exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42751766
194ether metabolic process (GO:0018904)2.40813804
195behavioral response to nicotine (GO:0035095)2.40028858
196GTP biosynthetic process (GO:0006183)2.39714389
197quinone biosynthetic process (GO:1901663)2.39050763
198protein targeting to mitochondrion (GO:0006626)2.36199754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.86350254
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.53183874
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.80799425
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.73270281
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.27852452
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.13803488
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.05136231
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.75021544
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.71176798
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.65574802
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.47115726
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.38560597
13GATA1_22025678_ChIP-Seq_K562_Human3.26862004
14EST1_17652178_ChIP-ChIP_JURKAT_Human3.20406180
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.89525377
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.76894505
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67224718
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.48780423
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.21502074
20VDR_22108803_ChIP-Seq_LS180_Human2.20838820
21VDR_23849224_ChIP-Seq_CD4+_Human2.20664403
22ZNF274_21170338_ChIP-Seq_K562_Hela2.15027118
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.12226193
24* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07939828
25EZH2_22144423_ChIP-Seq_EOC_Human2.05419563
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.05039279
27FUS_26573619_Chip-Seq_HEK293_Human2.04211564
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02746922
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95659381
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94677751
31FOXP3_21729870_ChIP-Seq_TREG_Human1.88577382
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85881413
33ELK1_19687146_ChIP-ChIP_HELA_Human1.84494650
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84053434
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.81230773
36GBX2_23144817_ChIP-Seq_PC3_Human1.76453803
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72721749
38TAF15_26573619_Chip-Seq_HEK293_Human1.69795158
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67109013
40TP53_22573176_ChIP-Seq_HFKS_Human1.67065990
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65541279
42HTT_18923047_ChIP-ChIP_STHdh_Human1.62460196
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.57098166
44IGF1R_20145208_ChIP-Seq_DFB_Human1.56962070
45EWS_26573619_Chip-Seq_HEK293_Human1.53929086
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49858320
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49448878
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46552670
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41601891
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35283142
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35135476
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34703173
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25887768
54MYC_18940864_ChIP-ChIP_HL60_Human1.25686390
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25434492
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23915671
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22243792
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.21448284
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21448284
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21078727
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20413146
62TTF2_22483619_ChIP-Seq_HELA_Human1.19169365
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18701679
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18319088
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17367118
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16863947
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16744094
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16087109
69NCOR_22424771_ChIP-Seq_293T_Human1.14838216
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14574906
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13818652
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12545242
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11007543
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10560947
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10560947
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10016426
77GABP_19822575_ChIP-Seq_HepG2_Human1.08111580
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.07870302
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.07664809
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06980925
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05283836
82* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04680821
83* NANOG_20526341_ChIP-Seq_ESCs_Human1.04478977
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02424915
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01634164
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01132830
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00196077
88ERG_20517297_ChIP-Seq_VCAP_Human1.00174441
89* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99477469
90* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99477469
91TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98976664
92HNF4A_19822575_ChIP-Seq_HepG2_Human0.98580914
93AR_20517297_ChIP-Seq_VCAP_Human0.96722537
94PHF8_20622853_ChIP-Seq_HELA_Human0.95871452
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.95600844
96SMRT_27268052_Chip-Seq_Bcells_Human0.95153240
97RBPJ_21746931_ChIP-Seq_IB4_Human0.93531723
98MYC_19829295_ChIP-Seq_ESCs_Human0.93175583
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.92626285
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92122530
101NANOG_18555785_Chip-Seq_ESCs_Mouse0.92026282
102TAL1_26923725_Chip-Seq_HPCs_Mouse0.91812050
103BP1_19119308_ChIP-ChIP_Hs578T_Human0.91489980
104NOTCH1_21737748_ChIP-Seq_TLL_Human0.91457048
105* FLI1_21867929_ChIP-Seq_TH2_Mouse0.91431317
106CBX2_27304074_Chip-Seq_ESCs_Mouse0.91254799
107IRF8_21731497_ChIP-ChIP_J774_Mouse0.90228549
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90043869
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89503586
110TCF4_22108803_ChIP-Seq_LS180_Human0.89147934
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88645555
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88581143
113BCAT_22108803_ChIP-Seq_LS180_Human0.88333862
114REST_21632747_ChIP-Seq_MESCs_Mouse0.88107421
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87894450
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87704433
117RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87472977
118SMAD4_21799915_ChIP-Seq_A2780_Human0.87002537
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86611120
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86512592
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86331244
122RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84675556
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83725065
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81964303
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81596158
126P300_19829295_ChIP-Seq_ESCs_Human0.81483294
127CBP_20019798_ChIP-Seq_JUKART_Human0.80242920
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80242920
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.79977670
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78579783
131NFE2_27457419_Chip-Seq_LIVER_Mouse0.78444741
132RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77470950
133GATA3_26560356_Chip-Seq_TH2_Human0.77126436
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77067263
135* NANOG_19829295_ChIP-Seq_ESCs_Human0.76425243
136* SOX2_19829295_ChIP-Seq_ESCs_Human0.76425243
137P53_22387025_ChIP-Seq_ESCs_Mouse0.76309571
138STAT1_17558387_ChIP-Seq_HELA_Human0.75649305
139SALL4_22934838_ChIP-ChIP_CD34+_Human0.75522969
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.73858601
141ZFP57_27257070_Chip-Seq_ESCs_Mouse0.73792224
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.73788369
143STAT3_18555785_Chip-Seq_ESCs_Mouse0.72871268
144EZH2_27294783_Chip-Seq_NPCs_Mouse0.72122072
145* AR_25329375_ChIP-Seq_VCAP_Human0.71574063
146FOXH1_21741376_ChIP-Seq_EPCs_Human0.67840304
147MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.67761383
148PU1_27457419_Chip-Seq_LIVER_Mouse0.67509212
149RARA_24833708_ChIP-Seq_LIVER_Mouse0.66642352
150SOX2_18555785_Chip-Seq_ESCs_Mouse0.66269960
151AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65960745
152SMAD1_18555785_Chip-Seq_ESCs_Mouse0.65915986
153ER_23166858_ChIP-Seq_MCF-7_Human0.63407038
154SUZ12_18555785_Chip-Seq_ESCs_Mouse0.62705269
155OCT4_20526341_ChIP-Seq_ESCs_Human0.62214313
156FLI1_27457419_Chip-Seq_LIVER_Mouse0.61797048
157CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.61347871
158KAP1_22055183_ChIP-Seq_ESCs_Mouse0.60522428
159SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.60287572
160P300_18555785_Chip-Seq_ESCs_Mouse0.60165259
161CTCF_18555785_Chip-Seq_ESCs_Mouse0.60090902
162MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.60039126
163EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.60015453
164GATA2_21666600_ChIP-Seq_HMVEC_Human0.59690536
165CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.59221890
166E2F1_18555785_Chip-Seq_ESCs_Mouse0.58983200
167EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.58948194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.29070248
2MP0005360_urolithiasis5.43295734
3MP0005085_abnormal_gallbladder_physiolo5.30513749
4MP0005365_abnormal_bile_salt5.30325355
5MP0008875_abnormal_xenobiotic_pharmacok4.35636272
6MP0003806_abnormal_nucleotide_metabolis3.58303588
7MP0003787_abnormal_imprinting3.42111871
8MP0008877_abnormal_DNA_methylation3.12266070
9MP0010329_abnormal_lipoprotein_level3.07750653
10MP0005410_abnormal_fertilization3.04370946
11MP0003195_calcinosis2.76740859
12MP0003252_abnormal_bile_duct2.76560532
13MP0005083_abnormal_biliary_tract2.69587551
14MP0005332_abnormal_amino_acid2.61881239
15MP0002638_abnormal_pupillary_reflex2.60256921
16MP0008058_abnormal_DNA_repair2.34385168
17MP0002876_abnormal_thyroid_physiology2.32203153
18MP0001764_abnormal_homeostasis2.13950730
19MP0001666_abnormal_nutrient_absorption2.11984283
20MP0000372_irregular_coat_pigmentation2.07961111
21MP0003123_paternal_imprinting2.06835327
22MP0002837_dystrophic_cardiac_calcinosis2.05873381
23MP0001529_abnormal_vocalization2.02854808
24MP0006036_abnormal_mitochondrial_physio1.99822870
25MP0009697_abnormal_copulation1.97334659
26MP0003011_delayed_dark_adaptation1.91721407
27MP0003121_genomic_imprinting1.85280337
28MP0009840_abnormal_foam_cell1.84915882
29MP0002118_abnormal_lipid_homeostasis1.84620308
30MP0005551_abnormal_eye_electrophysiolog1.76664366
31MP0005584_abnormal_enzyme/coenzyme_acti1.75284374
32MP0005319_abnormal_enzyme/_coenzyme1.74894559
33MP0004043_abnormal_pH_regulation1.73416051
34MP0003656_abnormal_erythrocyte_physiolo1.69511701
35MP0008995_early_reproductive_senescence1.67914894
36MP0004019_abnormal_vitamin_homeostasis1.67551352
37MP0006292_abnormal_olfactory_placode1.65414680
38MP0005646_abnormal_pituitary_gland1.64772581
39MP0001929_abnormal_gametogenesis1.60190688
40MP0001485_abnormal_pinna_reflex1.59258693
41MP0000609_abnormal_liver_physiology1.57394458
42MP0002138_abnormal_hepatobiliary_system1.56053547
43MP0003191_abnormal_cellular_cholesterol1.54509049
44MP0003718_maternal_effect1.53857477
45MP0000569_abnormal_digit_pigmentation1.53045895
46MP0003698_abnormal_male_reproductive1.49999428
47MP0002160_abnormal_reproductive_system1.47909284
48MP0005535_abnormal_body_temperature1.41042662
49MP0005389_reproductive_system_phenotype1.37061446
50MP0002234_abnormal_pharynx_morphology1.36741995
51MP0003186_abnormal_redox_activity1.36233452
52MP0002822_catalepsy1.35996235
53MP0002653_abnormal_ependyma_morphology1.35537268
54MP0006072_abnormal_retinal_apoptosis1.35010920
55MP0003122_maternal_imprinting1.31647873
56MP0005084_abnormal_gallbladder_morpholo1.31136593
57MP0005253_abnormal_eye_physiology1.30040786
58MP0001905_abnormal_dopamine_level1.29420412
59MP0005423_abnormal_somatic_nervous1.28038573
60MP0004742_abnormal_vestibular_system1.26883292
61MP0003868_abnormal_feces_composition1.24147064
62MP0009764_decreased_sensitivity_to1.22869293
63MP0009643_abnormal_urine_homeostasis1.20010153
64MP0003786_premature_aging1.19957577
65MP0003183_abnormal_peptide_metabolism1.18936800
66MP0006035_abnormal_mitochondrial_morpho1.16675358
67MP0002102_abnormal_ear_morphology1.16166605
68MP0002078_abnormal_glucose_homeostasis1.15524981
69MP0005636_abnormal_mineral_homeostasis1.14546827
70MP0004130_abnormal_muscle_cell1.14283419
71MP0004145_abnormal_muscle_electrophysio1.13816723
72MP0001486_abnormal_startle_reflex1.13585478
73MP0002132_abnormal_respiratory_system1.13180413
74MP0009379_abnormal_foot_pigmentation1.12356259
75MP0005075_abnormal_melanosome_morpholog1.11029610
76MP0004147_increased_porphyrin_level1.10523660
77MP0001919_abnormal_reproductive_system1.10389418
78MP0009780_abnormal_chondrocyte_physiolo1.10005058
79MP0003724_increased_susceptibility_to1.08892636
80MP0005379_endocrine/exocrine_gland_phen1.06905775
81MP0005187_abnormal_penis_morphology1.06695020
82MP0002210_abnormal_sex_determination1.06377923
83MP0002736_abnormal_nociception_after1.05803204
84MP0002277_abnormal_respiratory_mucosa1.05470487
85MP0001968_abnormal_touch/_nociception1.05117430
86MP0004782_abnormal_surfactant_physiolog1.04602046
87MP0001970_abnormal_pain_threshold1.03539768
88MP0001853_heart_inflammation1.03294362
89MP0003646_muscle_fatigue1.03030941
90MP0001963_abnormal_hearing_physiology1.02940965
91MP0005645_abnormal_hypothalamus_physiol1.02022266
92MP0008789_abnormal_olfactory_epithelium1.01519823
93MP0009046_muscle_twitch1.01446585
94MP0002229_neurodegeneration0.99613998
95MP0008775_abnormal_heart_ventricle0.98943788
96MP0002735_abnormal_chemical_nociception0.98425208
97MP0008469_abnormal_protein_level0.96063679
98MP0009745_abnormal_behavioral_response0.95816113
99MP0002095_abnormal_skin_pigmentation0.95626867
100MP0005174_abnormal_tail_pigmentation0.93971572
101MP0009642_abnormal_blood_homeostasis0.93726925
102MP0000604_amyloidosis0.92937505
103MP0002733_abnormal_thermal_nociception0.90792802
104MP0000653_abnormal_sex_gland0.90626782
105MP0001502_abnormal_circadian_rhythm0.88634574
106MP0008057_abnormal_DNA_replication0.88252618
107MP0008872_abnormal_physiological_respon0.88165596
108MP0000598_abnormal_liver_morphology0.88100261
109MP0002064_seizures0.87535415
110MP0004859_abnormal_synaptic_plasticity0.86967919
111MP0003635_abnormal_synaptic_transmissio0.86639882
112MP0009785_altered_susceptibility_to0.86299967
113MP0001145_abnormal_male_reproductive0.86169812
114MP0010386_abnormal_urinary_bladder0.85529034
115MP0001835_abnormal_antigen_presentation0.85426713
116MP0001756_abnormal_urination0.85026169
117MP0003879_abnormal_hair_cell0.83218470
118MP0002282_abnormal_trachea_morphology0.83067059
119MP0002734_abnormal_mechanical_nocicepti0.82348728
120MP0006276_abnormal_autonomic_nervous0.81912168
121MP0003880_abnormal_central_pattern0.81727130
122MP0003329_amyloid_beta_deposits0.81524109
123MP0005376_homeostasis/metabolism_phenot0.80680337
124MP0005166_decreased_susceptibility_to0.79482372
125MP0001501_abnormal_sleep_pattern0.77635073
126MP0002163_abnormal_gland_morphology0.77608986
127MP0001984_abnormal_olfaction0.77217280
128MP0005448_abnormal_energy_balance0.77131917
129MP0003953_abnormal_hormone_level0.77033715
130MP0003075_altered_response_to0.76719766
131MP0003633_abnormal_nervous_system0.76603553
132MP0002063_abnormal_learning/memory/cond0.76285319
133MP0005464_abnormal_platelet_physiology0.75082001
134MP0002909_abnormal_adrenal_gland0.74335580
135MP0002161_abnormal_fertility/fecundity0.73580877
136MP0001324_abnormal_eye_pigmentation0.73454115
137MP0000631_abnormal_neuroendocrine_gland0.73128557
138MP0005670_abnormal_white_adipose0.73001848
139MP0005367_renal/urinary_system_phenotyp0.72541261
140MP0000516_abnormal_urinary_system0.72541261
141MP0001293_anophthalmia0.72507709
142MP0001986_abnormal_taste_sensitivity0.71762641
143MP0002272_abnormal_nervous_system0.71634318
144MP0005195_abnormal_posterior_eye0.69811927
145MP0005647_abnormal_sex_gland0.69650495
146MP0005058_abnormal_lysosome_morphology0.69214041
147MP0009763_increased_sensitivity_to0.68517134
148MP0001765_abnormal_ion_homeostasis0.68203067
149MP0002572_abnormal_emotion/affect_behav0.67719899
150MP0000230_abnormal_systemic_arterial0.67695620
151MP0003943_abnormal_hepatobiliary_system0.67567393
152MP0000013_abnormal_adipose_tissue0.67330063
153MP0005334_abnormal_fat_pad0.67180227
154MP0008874_decreased_physiological_sensi0.63171283
155MP0005266_abnormal_metabolism0.60914012
156MP0003690_abnormal_glial_cell0.59418227
157MP0000639_abnormal_adrenal_gland0.58793288
158MP0004264_abnormal_extraembryonic_tissu0.58316041
159MP0009765_abnormal_xenobiotic_induced0.58093570
160MP0002419_abnormal_innate_immunity0.57263364
161MP0002067_abnormal_sensory_capabilities0.57134659
162MP0002090_abnormal_vision0.56873881
163MP0004142_abnormal_muscle_tone0.55160785

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.29553789
2Intrahepatic cholestasis (HP:0001406)4.66994484
3Prolonged partial thromboplastin time (HP:0003645)4.55902806
4Hypobetalipoproteinemia (HP:0003563)4.26840800
5Renal Fanconi syndrome (HP:0001994)4.18755170
6Deep venous thrombosis (HP:0002625)3.98287920
7Abnormality of fatty-acid metabolism (HP:0004359)3.97469343
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.97082190
93-Methylglutaconic aciduria (HP:0003535)3.94479521
10Increased hepatocellular lipid droplets (HP:0006565)3.88659106
11Ketosis (HP:0001946)3.82823015
12Generalized aminoaciduria (HP:0002909)3.79453010
13Hyperammonemia (HP:0001987)3.68998165
14Xanthomatosis (HP:0000991)3.66958829
15Mitochondrial inheritance (HP:0001427)3.66681110
16Absent/shortened dynein arms (HP:0200106)3.63426421
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.63426421
18Hypoglycemic coma (HP:0001325)3.62034021
19Ketoacidosis (HP:0001993)3.61417181
20Acute necrotizing encephalopathy (HP:0006965)3.60588771
21Hyperglycinemia (HP:0002154)3.57730629
22Conjugated hyperbilirubinemia (HP:0002908)3.50615080
23Hyperglycinuria (HP:0003108)3.47289771
24Lipid accumulation in hepatocytes (HP:0006561)3.46873876
25Hyperlipoproteinemia (HP:0010980)3.45728446
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44922523
27Abnormality of the intrinsic pathway (HP:0010989)3.40044785
28Abnormality of renal resorption (HP:0011038)3.39862622
29Abnormality of serine family amino acid metabolism (HP:0010894)3.35845971
30Abnormality of glycine metabolism (HP:0010895)3.35845971
31Molar tooth sign on MRI (HP:0002419)3.35815731
32Abnormality of midbrain morphology (HP:0002418)3.35815731
33Joint hemorrhage (HP:0005261)3.19903516
34Hyperbilirubinemia (HP:0002904)3.18401387
35Increased intramyocellular lipid droplets (HP:0012240)3.11550582
36Progressive macrocephaly (HP:0004481)3.11213669
37Complement deficiency (HP:0004431)3.09042705
38Abnormality of the common coagulation pathway (HP:0010990)3.07830547
39Abnormality of sulfur amino acid metabolism (HP:0004339)3.07126437
40Medial flaring of the eyebrow (HP:0010747)3.07094468
41Fat malabsorption (HP:0002630)3.05942290
42Nephronophthisis (HP:0000090)3.01760583
43Exertional dyspnea (HP:0002875)2.99949531
44Abnormal hair whorl (HP:0010721)2.96948803
45Abnormality of methionine metabolism (HP:0010901)2.96467306
46Metabolic acidosis (HP:0001942)2.94949858
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.89713475
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.89633807
49Tubulointerstitial nephritis (HP:0001970)2.87465018
50Pancreatic cysts (HP:0001737)2.87156884
51True hermaphroditism (HP:0010459)2.86693872
52Gout (HP:0001997)2.85154397
53Progressive microcephaly (HP:0000253)2.84282077
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.83255264
55Dicarboxylic aciduria (HP:0003215)2.83255264
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81853841
57Abnormality of alanine metabolism (HP:0010916)2.81853841
58Hyperalaninemia (HP:0003348)2.81853841
59Hypolipoproteinemia (HP:0010981)2.81056167
60Abnormal ciliary motility (HP:0012262)2.77517954
61Pancreatic fibrosis (HP:0100732)2.72515800
62Abnormal respiratory motile cilium morphology (HP:0005938)2.71413807
63Abnormal respiratory epithelium morphology (HP:0012253)2.71413807
64Hepatic necrosis (HP:0002605)2.66286832
65Epidermoid cyst (HP:0200040)2.65436858
66Abnormality of purine metabolism (HP:0004352)2.64914066
67Abnormal respiratory motile cilium physiology (HP:0012261)2.64067588
68Abnormality of serum amino acid levels (HP:0003112)2.62524040
69Abnormal gallbladder morphology (HP:0012437)2.61516214
70Respiratory difficulties (HP:0002880)2.61228371
71Increased muscle lipid content (HP:0009058)2.60510242
72Increased serum lactate (HP:0002151)2.59889172
73Recurrent gram-negative bacterial infections (HP:0005420)2.58123105
74Abnormality of nucleobase metabolism (HP:0010932)2.57455547
75Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.56780258
76Bile duct proliferation (HP:0001408)2.55919143
77Abnormal biliary tract physiology (HP:0012439)2.55919143
78Cerebral edema (HP:0002181)2.52632487
79Lethargy (HP:0001254)2.51611754
80Steatorrhea (HP:0002570)2.50300857
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.49908037
82Focal motor seizures (HP:0011153)2.47713109
83Congenital primary aphakia (HP:0007707)2.46852914
84Cholelithiasis (HP:0001081)2.45820903
85Hypoglycemic seizures (HP:0002173)2.45140981
86Delayed CNS myelination (HP:0002188)2.44708259
87Gait imbalance (HP:0002141)2.43045926
88Abnormality of the renal medulla (HP:0100957)2.42555528
89Abnormality of pyrimidine metabolism (HP:0004353)2.42538509
90Nephrogenic diabetes insipidus (HP:0009806)2.41584930
91Sensorimotor neuropathy (HP:0007141)2.39926834
92Renal cortical cysts (HP:0000803)2.37921435
93Oligomenorrhea (HP:0000876)2.33304254
94Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31873930
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31873930
96Abnormal rod and cone electroretinograms (HP:0008323)2.30749090
97Abnormality of the renal cortex (HP:0011035)2.26205259
98Proximal tubulopathy (HP:0000114)2.26023767
99Neuroendocrine neoplasm (HP:0100634)2.23377826
100Methylmalonic aciduria (HP:0012120)2.21327573
101Vomiting (HP:0002013)2.19641771
102Severe global developmental delay (HP:0011344)2.18806957
103Abnormality of dental color (HP:0011073)2.17642768
104Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17046677
105Chronic hepatic failure (HP:0100626)2.16381479
106Pheochromocytoma (HP:0002666)2.16266987
107Abnormal gallbladder physiology (HP:0012438)2.15417280
108Cholecystitis (HP:0001082)2.15417280
109Hyperventilation (HP:0002883)2.14747516
110Acute encephalopathy (HP:0006846)2.12745884
111Symptomatic seizures (HP:0011145)2.12483140
112Hepatocellular necrosis (HP:0001404)2.11598710
113Elevated erythrocyte sedimentation rate (HP:0003565)2.10379479
114Hypercholesterolemia (HP:0003124)2.09503643
115Methylmalonic acidemia (HP:0002912)2.09300984
116Reduced antithrombin III activity (HP:0001976)2.09063629
117Abnormal number of erythroid precursors (HP:0012131)2.06369570
118Hypoalphalipoproteinemia (HP:0003233)2.06231498
119Patent foramen ovale (HP:0001655)2.06005356
120Opisthotonus (HP:0002179)2.05008758
121Panhypogammaglobulinemia (HP:0003139)2.04993558
122Lactic acidosis (HP:0003128)2.01843373
123Abnormality of the gallbladder (HP:0005264)2.01348212
124Optic disc pallor (HP:0000543)2.00926185
125Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99578419
126Abnormality of complement system (HP:0005339)1.99399497
127Alkalosis (HP:0001948)1.98689724
128Abnormality of cells of the erythroid lineage (HP:0012130)1.98673410
129Leukodystrophy (HP:0002415)1.97747314
130Skin nodule (HP:0200036)1.96032015
131Glycosuria (HP:0003076)1.95748103
132Abnormality of urine glucose concentration (HP:0011016)1.95748103
133Menorrhagia (HP:0000132)1.95181159
134Hyperinsulinemic hypoglycemia (HP:0000825)1.95107531
135Attenuation of retinal blood vessels (HP:0007843)1.94954892
136Abnormal mitochondria in muscle tissue (HP:0008316)1.93367566
137Abnormality of glycolysis (HP:0004366)1.92823832
138Increased serum pyruvate (HP:0003542)1.92823832
139Mitral stenosis (HP:0001718)1.91693437
140Rhinitis (HP:0012384)1.91449099
141Spontaneous abortion (HP:0005268)1.90945880
142Poikilocytosis (HP:0004447)1.89210009
143Acute hepatic failure (HP:0006554)1.88851573
144Hyperphosphaturia (HP:0003109)1.88138838
145Myokymia (HP:0002411)1.87894087
146Fair hair (HP:0002286)1.86747558
147Exercise intolerance (HP:0003546)1.86152146
148Pancreatitis (HP:0001733)1.85566466
149Irritability (HP:0000737)1.85033743
150Myoglobinuria (HP:0002913)1.84934810
151Increased purine levels (HP:0004368)1.84910363
152Hyperuricemia (HP:0002149)1.84910363
153Late onset (HP:0003584)1.84871641
154Type II lissencephaly (HP:0007260)1.84689335
155Cerebral hypomyelination (HP:0006808)1.83855600
156Increased CSF lactate (HP:0002490)1.81123378
157Cerebral palsy (HP:0100021)1.79997721
158Neonatal onset (HP:0003623)1.79368388
159Anencephaly (HP:0002323)1.79308905
160CNS demyelination (HP:0007305)1.78947411
161Hypomagnesemia (HP:0002917)1.78731074
162Congenital, generalized hypertrichosis (HP:0004540)1.78484965
163Nausea (HP:0002018)1.78280533
164Hepatocellular carcinoma (HP:0001402)1.76999682
165Brushfield spots (HP:0001088)1.76507192
166Status epilepticus (HP:0002133)1.76025872
167Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75673529
168Cystic liver disease (HP:0006706)1.73040452
169Optic nerve hypoplasia (HP:0000609)1.71461710
170Tetany (HP:0001281)1.71100434
171Genital tract atresia (HP:0001827)1.70298027
172Abnormal drinking behavior (HP:0030082)1.68664859
173Polydipsia (HP:0001959)1.68664859
174CNS hypomyelination (HP:0003429)1.67731950
175Abolished electroretinogram (ERG) (HP:0000550)1.67170231
176Oculomotor apraxia (HP:0000657)1.67052856
177Respiratory failure (HP:0002878)1.65976266
178Bony spicule pigmentary retinopathy (HP:0007737)1.65665434
179Sclerocornea (HP:0000647)1.65034769
180Vaginal atresia (HP:0000148)1.64822153
181Atonic seizures (HP:0010819)1.63688118
182Congenital hepatic fibrosis (HP:0002612)1.63558158
183Congenital stationary night blindness (HP:0007642)1.61950231
184Progressive cerebellar ataxia (HP:0002073)1.59422612
185Poor coordination (HP:0002370)1.59372555
186Emotional lability (HP:0000712)1.58266751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.12342316
2BCKDK3.92780922
3SIK33.10060574
4PLK42.66334327
5CASK2.37943430
6MUSK2.32340870
7DAPK22.31978599
8TAOK32.24832860
9MAP2K42.23337720
10AKT32.19913751
11INSRR2.19750756
12ZAK2.16630982
13MAP4K22.15894964
14SGK22.15819800
15MAP2K72.12751557
16ACVR1B1.99480935
17CCNB11.91238581
18DAPK11.83217806
19NUAK11.77908459
20NEK91.67770734
21SGK31.66173562
22TSSK61.66152327
23SGK2231.63731213
24SGK4941.63731213
25PRPF4B1.61476783
26MYLK1.52411767
27NEK11.48154088
28NTRK31.42630437
29FGFR41.42033681
30MAP2K61.40413370
31MST41.39981945
32TXK1.34919914
33BMPR1B1.34401695
34MINK11.30526993
35IRAK31.30273425
36PDK41.29293511
37PDK31.29293511
38BMPR21.28068415
39TAOK21.26094259
40MAP3K141.25816963
41PIK3CG1.24947486
42MAP2K31.22872993
43PDK21.21035061
44FLT31.20204123
45PINK11.19680050
46MAPK131.17953028
47FRK1.17034645
48STK161.16484941
49VRK21.16205301
50MAP3K41.15224336
51ARAF1.13897416
52ADRBK21.13223912
53TIE11.12873014
54RIPK41.12725272
55PNCK1.10674713
56SIK11.08981499
57EPHA41.06540506
58IRAK41.06524049
59WNK31.03236418
60KIT1.03070304
61CAMKK20.98873576
62PBK0.96574687
63TRIM280.94386297
64BRAF0.93929213
65ERN10.93616747
66CDK190.89699307
67VRK10.89220064
68PRKCG0.89113332
69RPS6KB10.88225097
70TNIK0.87871624
71FES0.86622917
72MAPK110.85915245
73STK38L0.84069992
74TEC0.83710971
75ERBB30.82989360
76BRSK20.82942488
77DYRK20.82175044
78BUB10.80167169
79TESK20.78153519
80GRK60.76948453
81JAK10.76690052
82PLK20.76328780
83OXSR10.74398634
84DYRK30.72264331
85CAMKK10.70932493
86NEK20.70673606
87MAPKAPK30.68336709
88MARK30.68104770
89EIF2AK10.67817378
90GRK10.67388225
91MAP3K110.67331226
92TBK10.65469219
93SYK0.65286293
94NEK60.64491042
95PIK3CA0.64024642
96ZAP700.62978600
97CSNK1G30.62300545
98CAMK1G0.62198721
99RPS6KA20.62163501
100CSNK1G20.61709543
101EIF2AK30.61287927
102PRKCH0.60963045
103MAPKAPK50.60828435
104GRK70.58224360
105JAK20.58053334
106PDK10.57657399
107MAP3K130.56695868
108BRSK10.56101394
109PTK2B0.55877945
110PAK30.55876152
111MAP3K70.55535500
112PDPK10.55113800
113LRRK20.54034345
114MAP3K10.53653937
115PRKCQ0.53302648
116CAMK1D0.52876981
117TESK10.51808466
118MKNK10.51733509
119RPS6KA50.50848840
120PKN10.49395402
121ADRBK10.49179742
122PIM20.48635405
123CAMK10.48617846
124PLK10.48044173
125MAPK150.46218679
126CSNK1A1L0.45973582
127MAP3K50.45759312
128MAPK120.45370533
129PRKACG0.44964984
130TYK20.44723897
131ITK0.44023180
132OBSCN0.43678965
133MAP4K10.43497582
134NTRK20.43000101
135TNK20.42835876
136IKBKB0.42194841
137TLK10.41329347
138STK380.40879953
139PRKACA0.40704514
140ERBB40.40469228
141ABL20.40131947
142GRK50.40049277
143MAPK40.39733094
144CSNK1G10.39527489
145PRKD30.39410014
146MKNK20.38423088
147PRKCE0.37011400
148BTK0.36860989
149NME10.36709888
150DYRK1A0.35406634
151CSNK2A20.35393741
152MAP2K10.35051474
153PRKACB0.35028825
154CDK80.34997838
155PLK30.34815248
156STK110.34670282
157CHEK20.34364547
158CDC70.33307631

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.93635584
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.56241306
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.53983132
4Ribosome_Homo sapiens_hsa030103.40661508
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.79081685
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75204255
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.73198591
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.66444445
9Huntingtons disease_Homo sapiens_hsa050162.56859311
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.54595111
11Propanoate metabolism_Homo sapiens_hsa006402.51309545
12RNA polymerase_Homo sapiens_hsa030202.47023826
13Fatty acid degradation_Homo sapiens_hsa000712.46751502
14Arginine biosynthesis_Homo sapiens_hsa002202.45673611
15Tryptophan metabolism_Homo sapiens_hsa003802.33998739
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32587439
17Proteasome_Homo sapiens_hsa030502.24262978
18Butanoate metabolism_Homo sapiens_hsa006502.22298652
19Homologous recombination_Homo sapiens_hsa034402.16239301
20Peroxisome_Homo sapiens_hsa041462.14398189
21Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07474852
22Nitrogen metabolism_Homo sapiens_hsa009101.94779615
23Fatty acid metabolism_Homo sapiens_hsa012121.92072146
24Pyruvate metabolism_Homo sapiens_hsa006201.90038847
25Basal transcription factors_Homo sapiens_hsa030221.86438189
26Complement and coagulation cascades_Homo sapiens_hsa046101.85759542
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85190746
28Fanconi anemia pathway_Homo sapiens_hsa034601.80525104
29Cardiac muscle contraction_Homo sapiens_hsa042601.76412361
30beta-Alanine metabolism_Homo sapiens_hsa004101.75658198
31Sulfur metabolism_Homo sapiens_hsa009201.75494771
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70844026
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64546370
34Carbon metabolism_Homo sapiens_hsa012001.63745951
35Fatty acid elongation_Homo sapiens_hsa000621.62649124
36Histidine metabolism_Homo sapiens_hsa003401.61208338
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60585453
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.51850525
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51614230
40PPAR signaling pathway_Homo sapiens_hsa033201.47892112
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.43768946
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.42905764
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42550424
44Phenylalanine metabolism_Homo sapiens_hsa003601.42098068
45Starch and sucrose metabolism_Homo sapiens_hsa005001.39334968
46Nucleotide excision repair_Homo sapiens_hsa034201.36758802
47Mismatch repair_Homo sapiens_hsa034301.36752117
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36644936
49Chemical carcinogenesis_Homo sapiens_hsa052041.35962583
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34123197
51Phototransduction_Homo sapiens_hsa047441.33547632
52Biosynthesis of amino acids_Homo sapiens_hsa012301.30233226
53Pyrimidine metabolism_Homo sapiens_hsa002401.29528278
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19886764
55Purine metabolism_Homo sapiens_hsa002301.15130276
56Spliceosome_Homo sapiens_hsa030401.14322755
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14197391
58Selenocompound metabolism_Homo sapiens_hsa004501.13697539
59Bile secretion_Homo sapiens_hsa049761.13676852
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13030409
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11100401
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10540516
63Caffeine metabolism_Homo sapiens_hsa002321.10353396
64Staphylococcus aureus infection_Homo sapiens_hsa051501.10084746
65Retinol metabolism_Homo sapiens_hsa008301.09204692
66Maturity onset diabetes of the young_Homo sapiens_hsa049501.08101291
67Tyrosine metabolism_Homo sapiens_hsa003501.07940017
68Base excision repair_Homo sapiens_hsa034101.06136281
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05241807
70Folate biosynthesis_Homo sapiens_hsa007901.04926668
71Synaptic vesicle cycle_Homo sapiens_hsa047211.03883187
72RNA degradation_Homo sapiens_hsa030180.99484965
73Collecting duct acid secretion_Homo sapiens_hsa049660.96465220
74ABC transporters_Homo sapiens_hsa020100.90817470
75Non-homologous end-joining_Homo sapiens_hsa034500.88132874
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86965133
77Fructose and mannose metabolism_Homo sapiens_hsa000510.86613002
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84660209
79Vitamin B6 metabolism_Homo sapiens_hsa007500.81434045
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75869836
81Circadian rhythm_Homo sapiens_hsa047100.74935555
82DNA replication_Homo sapiens_hsa030300.69357740
83Galactose metabolism_Homo sapiens_hsa000520.69268100
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.67566604
85Arginine and proline metabolism_Homo sapiens_hsa003300.66886794
86Pentose phosphate pathway_Homo sapiens_hsa000300.66560802
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65996207
88RNA transport_Homo sapiens_hsa030130.65225940
89One carbon pool by folate_Homo sapiens_hsa006700.64131066
90Oocyte meiosis_Homo sapiens_hsa041140.63428154
91Glycerolipid metabolism_Homo sapiens_hsa005610.63207801
92Vitamin digestion and absorption_Homo sapiens_hsa049770.62400451
93Fat digestion and absorption_Homo sapiens_hsa049750.60519053
94Primary immunodeficiency_Homo sapiens_hsa053400.55211911
95Metabolic pathways_Homo sapiens_hsa011000.55027364
96Asthma_Homo sapiens_hsa053100.54821660
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50854739
98GABAergic synapse_Homo sapiens_hsa047270.50271135
99Oxidative phosphorylation_Homo sapiens_hsa001900.50151155
100Steroid biosynthesis_Homo sapiens_hsa001000.50123978
101Protein export_Homo sapiens_hsa030600.48597697
102Serotonergic synapse_Homo sapiens_hsa047260.47552306
103Vibrio cholerae infection_Homo sapiens_hsa051100.45758711
104Nicotine addiction_Homo sapiens_hsa050330.42373081
105Fatty acid biosynthesis_Homo sapiens_hsa000610.38698094
106Olfactory transduction_Homo sapiens_hsa047400.36779629
107Regulation of autophagy_Homo sapiens_hsa041400.35672395
108Glutathione metabolism_Homo sapiens_hsa004800.34982476
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34579384
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34497751
111Glucagon signaling pathway_Homo sapiens_hsa049220.33411256
112Taste transduction_Homo sapiens_hsa047420.33043553
113Insulin secretion_Homo sapiens_hsa049110.32447506
114Lysine degradation_Homo sapiens_hsa003100.31429095
115Morphine addiction_Homo sapiens_hsa050320.31084749
116Dopaminergic synapse_Homo sapiens_hsa047280.30825435
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30275510
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29903438
119Arachidonic acid metabolism_Homo sapiens_hsa005900.29579253
120Sulfur relay system_Homo sapiens_hsa041220.28750776
121Parkinsons disease_Homo sapiens_hsa050120.28346420
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27632603
123Phagosome_Homo sapiens_hsa041450.27589030
124Dorso-ventral axis formation_Homo sapiens_hsa043200.26988090
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.26561516
126Salivary secretion_Homo sapiens_hsa049700.26391342
127Linoleic acid metabolism_Homo sapiens_hsa005910.24058021
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23254229
129Calcium signaling pathway_Homo sapiens_hsa040200.23074680
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23048074
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21778064
132Cocaine addiction_Homo sapiens_hsa050300.21157757
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18628343
134Circadian entrainment_Homo sapiens_hsa047130.18068644
135Insulin resistance_Homo sapiens_hsa049310.17890519
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.15354336
137Lysosome_Homo sapiens_hsa041420.14050467
138Type I diabetes mellitus_Homo sapiens_hsa049400.12140907
139Alzheimers disease_Homo sapiens_hsa050100.11842940
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11768152
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07516845
142Rheumatoid arthritis_Homo sapiens_hsa053230.07020802
143Thyroid hormone synthesis_Homo sapiens_hsa049180.03609656
144Prion diseases_Homo sapiens_hsa050200.03465379
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.03442806
146Amphetamine addiction_Homo sapiens_hsa050310.03394510

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