CDAN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.89483538
2mannose metabolic process (GO:0006013)4.78616785
3dosage compensation (GO:0007549)4.16666461
4microtubule depolymerization (GO:0007019)3.83830590
5mucosal-associated lymphoid tissue development (GO:0048537)3.79992897
6Peyers patch development (GO:0048541)3.79992897
7histone H3-K36 demethylation (GO:0070544)3.74993663
8regulation of chromatin binding (GO:0035561)3.69863585
9DNA topological change (GO:0006265)3.65913356
10positive regulation of histone deacetylation (GO:0031065)3.65853595
11nuclear pore complex assembly (GO:0051292)3.61849611
12mitotic recombination (GO:0006312)3.59314250
13protein localization to chromosome, centromeric region (GO:0071459)3.56104750
14DNA replication initiation (GO:0006270)3.56005508
15negative regulation of granulocyte differentiation (GO:0030853)3.53064057
16response to muramyl dipeptide (GO:0032495)3.52020935
17protein K6-linked ubiquitination (GO:0085020)3.49279254
18regulation of RNA export from nucleus (GO:0046831)3.49002162
19mitotic sister chromatid cohesion (GO:0007064)3.44194420
20regulation of histone H3-K9 methylation (GO:0051570)3.44178054
21DNA strand elongation involved in DNA replication (GO:0006271)3.38521776
22DNA replication checkpoint (GO:0000076)3.38007933
23DNA strand elongation (GO:0022616)3.37785140
24telomere maintenance via semi-conservative replication (GO:0032201)3.35899725
25pore complex assembly (GO:0046931)3.34198422
26positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.32707753
27histone H4 deacetylation (GO:0070933)3.31267435
28negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.30835190
29mitotic sister chromatid segregation (GO:0000070)3.30151275
30telomere maintenance via recombination (GO:0000722)3.29334420
31histone demethylation (GO:0016577)3.24951798
32protein localization to kinetochore (GO:0034501)3.23954499
33regulation of histone H3-K27 methylation (GO:0061085)3.23519245
34histone H3 deacetylation (GO:0070932)3.23436963
35nuclear pore organization (GO:0006999)3.22424913
36apoptotic process involved in morphogenesis (GO:0060561)3.20933019
37thymic T cell selection (GO:0045061)3.19447396
38histone lysine demethylation (GO:0070076)3.19274383
39regulation of histone H3-K4 methylation (GO:0051569)3.17621547
40positive regulation of gamma-delta T cell activation (GO:0046645)3.16964619
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14016647
42negative regulation of telomere maintenance (GO:0032205)3.13478745
43regulation of fatty acid beta-oxidation (GO:0031998)3.13186690
44negative regulation of DNA-dependent DNA replication (GO:2000104)3.12468945
45sister chromatid segregation (GO:0000819)3.11683035
46histone lysine methylation (GO:0034968)3.11418233
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.09296476
48mitotic metaphase plate congression (GO:0007080)3.02092639
49regulation of translational fidelity (GO:0006450)3.01486542
50regulation of DNA endoreduplication (GO:0032875)3.01424402
51negative regulation of histone methylation (GO:0031061)3.00635966
52protein dealkylation (GO:0008214)3.00145219
53protein demethylation (GO:0006482)3.00145219
54regulation of gamma-delta T cell differentiation (GO:0045586)2.99920036
55positive regulation of protein deacetylation (GO:0090312)2.99345610
56DNA synthesis involved in DNA repair (GO:0000731)2.98858382
57positive regulation of chromosome segregation (GO:0051984)2.98628938
58granulocyte differentiation (GO:0030851)2.98294885
59translesion synthesis (GO:0019985)2.97772226
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97038529
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97038529
62positive regulation of mitotic sister chromatid separation (GO:1901970)2.97038529
63snRNA metabolic process (GO:0016073)2.96519082
64glucocorticoid receptor signaling pathway (GO:0042921)2.96367159
65piRNA metabolic process (GO:0034587)2.94046435
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93459101
67monoubiquitinated protein deubiquitination (GO:0035520)2.91736549
68histone H3-K9 methylation (GO:0051567)2.91028463
69regulation of integrin activation (GO:0033623)2.89947822
70positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.87985691
71regulation of spindle organization (GO:0090224)2.87230924
72metaphase plate congression (GO:0051310)2.86575994
73regulation of granulocyte differentiation (GO:0030852)2.86565487
74sister chromatid cohesion (GO:0007062)2.85551731
75mitotic chromosome condensation (GO:0007076)2.84798448
76regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.84175599
77regulation of nucleobase-containing compound transport (GO:0032239)2.83974467
78focal adhesion assembly (GO:0048041)2.83518496
79cell-substrate adherens junction assembly (GO:0007045)2.83518496
80histone methylation (GO:0016571)2.83466913
81DNA unwinding involved in DNA replication (GO:0006268)2.83373124
82atrioventricular valve morphogenesis (GO:0003181)2.83205802
83modulation by virus of host process (GO:0019054)2.83193321
84corticosteroid receptor signaling pathway (GO:0031958)2.81518325
85intracellular estrogen receptor signaling pathway (GO:0030520)2.81190565
86regulation of monocyte differentiation (GO:0045655)2.80375837
87positive thymic T cell selection (GO:0045059)2.77150295
88positive regulation of CREB transcription factor activity (GO:0032793)2.76906249
89meiotic chromosome segregation (GO:0045132)2.76795272
90activation of Rac GTPase activity (GO:0032863)2.75061965
91DNA replication-independent nucleosome assembly (GO:0006336)2.74494603
92DNA replication-independent nucleosome organization (GO:0034724)2.74494603
93histone H3-K4 methylation (GO:0051568)2.73977177
94kinetochore organization (GO:0051383)2.73524746
95poly(A)+ mRNA export from nucleus (GO:0016973)2.73380760
96B cell receptor signaling pathway (GO:0050853)2.73284507
97positive regulation of DNA-templated transcription, initiation (GO:2000144)2.72857719
98male meiosis I (GO:0007141)2.72776668
99regulation of telomere maintenance (GO:0032204)2.72334166
100UV protection (GO:0009650)2.70567490
101centriole assembly (GO:0098534)2.70543100
102regulation of gamma-delta T cell activation (GO:0046643)2.70033509
103insulin-like growth factor receptor signaling pathway (GO:0048009)2.69329316
104negative thymic T cell selection (GO:0045060)2.68843517
105histone H3-K4 trimethylation (GO:0080182)2.67830665
106nucleotide-excision repair, DNA gap filling (GO:0006297)2.67827906
107positive regulation of gene expression, epigenetic (GO:0045815)2.67229611
108positive regulation by host of viral transcription (GO:0043923)2.67163315
109DNA packaging (GO:0006323)2.66625267
110spliceosomal tri-snRNP complex assembly (GO:0000244)2.65950940
111acrosome assembly (GO:0001675)2.65312912
112natural killer cell differentiation (GO:0001779)2.65250821
113V(D)J recombination (GO:0033151)2.64456951
114histone deacetylation (GO:0016575)2.64267118
115fusion of sperm to egg plasma membrane (GO:0007342)2.63939586
116histone H2A acetylation (GO:0043968)2.63427029
117snRNA processing (GO:0016180)2.61454047
118DNA duplex unwinding (GO:0032508)2.60991606
119DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.60915374
120DNA damage response, signal transduction resulting in transcription (GO:0042772)2.60737233
121regulation of mitotic spindle organization (GO:0060236)2.60703118
122protein localization to chromosome (GO:0034502)2.60651183
123DNA geometric change (GO:0032392)2.60260239
124telomere maintenance via telomere lengthening (GO:0010833)2.60153912
125establishment of chromosome localization (GO:0051303)2.60080747
126T cell selection (GO:0045058)2.59790574
127telomere maintenance (GO:0000723)2.59420325
128chromosome condensation (GO:0030261)2.59058502
129DNA methylation (GO:0006306)2.58628410
130DNA alkylation (GO:0006305)2.58628410
131cilium or flagellum-dependent cell motility (GO:0001539)2.58317399
132DNA conformation change (GO:0071103)2.58166066
133positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.57374243
134DNA ligation (GO:0006266)2.57225975
135pyrimidine dimer repair (GO:0006290)2.57190328
136peptidyl-lysine trimethylation (GO:0018023)2.57058174
137gene silencing by RNA (GO:0031047)2.56690919
138telomere organization (GO:0032200)2.55676923
139positive regulation of fatty acid beta-oxidation (GO:0032000)2.55466277
140folic acid metabolic process (GO:0046655)2.55395522
141megakaryocyte development (GO:0035855)2.55143944
142termination of RNA polymerase II transcription (GO:0006369)2.55113874
143NIK/NF-kappaB signaling (GO:0038061)2.54967349
144regulation of DNA-dependent DNA replication (GO:0090329)2.54403484
145negative T cell selection (GO:0043383)2.54242897
146CENP-A containing nucleosome assembly (GO:0034080)2.52917992
147regulation of centriole replication (GO:0046599)2.52647976
148chromosome organization (GO:0051276)2.52563600
1493-UTR-mediated mRNA stabilization (GO:0070935)2.52023936
150negative regulation of cell size (GO:0045792)2.50695557
151interferon-gamma production (GO:0032609)2.49913755
152negative regulation of myotube differentiation (GO:0010832)2.49469213
153regulation of histone methylation (GO:0031060)2.49076869
154chromatin remodeling at centromere (GO:0031055)2.48969434
155centriole replication (GO:0007099)2.48588445
156histone H3-K9 modification (GO:0061647)2.48011890
157histone exchange (GO:0043486)2.47726629
158synaptonemal complex assembly (GO:0007130)2.47497287
159negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.47194825
160definitive hemopoiesis (GO:0060216)2.46852155
161interkinetic nuclear migration (GO:0022027)2.46812814
162regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.46658042
163positive regulation of granulocyte differentiation (GO:0030854)2.46155377
164protein-DNA complex disassembly (GO:0032986)2.46110372
165nucleosome disassembly (GO:0006337)2.46110372
166retrograde transport, endosome to Golgi (GO:0042147)2.45621149
167peptidyl-lysine methylation (GO:0018022)2.45435487
168protein deacetylation (GO:0006476)2.45057949
169kinetochore assembly (GO:0051382)2.45041788
170inner cell mass cell proliferation (GO:0001833)2.44938712
171meiotic cell cycle (GO:0051321)2.44909221
172neural tube development (GO:0021915)2.44391140
173chromosome organization involved in meiosis (GO:0070192)2.43964356
174motile cilium assembly (GO:0044458)2.43745893
175CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.43689534
176ATP-dependent chromatin remodeling (GO:0043044)2.43313062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.83619928
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.82486271
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.88666476
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.54093434
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99656065
6SCL_19346495_ChIP-Seq_HPC-7_Human2.86379234
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.56121101
8MYC_22102868_ChIP-Seq_BL_Human2.54283084
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51410383
10LXR_22292898_ChIP-Seq_THP-1_Human2.50736902
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.33021783
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23725981
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21210355
14VDR_21846776_ChIP-Seq_THP-1_Human2.15425844
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12869214
16ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.12165862
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07333276
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05488428
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05289624
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.03187546
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.01824950
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98175873
23CIITA_25753668_ChIP-Seq_RAJI_Human1.96262314
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.92755524
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85467307
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84641558
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83760220
28P68_20966046_ChIP-Seq_HELA_Human1.81766551
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.79863310
30RACK7_27058665_Chip-Seq_MCF-7_Human1.77212119
31KDM2B_26808549_Chip-Seq_JURKAT_Human1.76468106
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73891396
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.72821093
34MYB_26560356_Chip-Seq_TH1_Human1.72475994
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71264139
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.68975356
37SPI1_23547873_ChIP-Seq_NB4_Human1.68417647
38MYB_26560356_Chip-Seq_TH2_Human1.65291331
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64469536
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62990665
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.62695530
42KDM2B_26808549_Chip-Seq_K562_Human1.61947892
43FOXP3_21729870_ChIP-Seq_TREG_Human1.59474661
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59064533
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58628647
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.56608193
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55913680
48TCF7_22412390_ChIP-Seq_EML_Mouse1.54626089
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54255654
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51442249
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49986670
52* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49030472
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49003728
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.48980700
55SMC4_20622854_ChIP-Seq_HELA_Human1.48047295
56MAF_26560356_Chip-Seq_TH1_Human1.47277403
57UTX_26944678_Chip-Seq_JUKART_Human1.44911741
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44324165
59CREB1_26743006_Chip-Seq_LNCaP_Human1.44000157
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.43835042
61* VDR_23849224_ChIP-Seq_CD4+_Human1.41698524
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.41386890
63* KDM5A_27292631_Chip-Seq_BREAST_Human1.40743772
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40260161
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39687929
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39682499
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38110711
68* IRF8_27001747_Chip-Seq_BMDM_Mouse1.36920970
69* TET1_21451524_ChIP-Seq_MESCs_Mouse1.34725542
70VDR_24763502_ChIP-Seq_THP-1_Human1.34561154
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34544964
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34375243
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34310072
74BCOR_27268052_Chip-Seq_Bcells_Human1.32992369
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32275119
76PKCTHETA_26484144_Chip-Seq_BREAST_Human1.31253841
77* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30678945
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29801812
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29743096
80TP53_22127205_ChIP-Seq_IMR90_Human1.29334195
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28438404
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28005769
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26779389
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26578089
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26125710
86GATA1_22025678_ChIP-Seq_K562_Human1.25787826
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25682178
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25413296
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23748755
90GATA1_19941826_ChIP-Seq_K562_Human1.23237532
91NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22123715
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21974334
93BCL6_27268052_Chip-Seq_Bcells_Human1.21927644
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.21223768
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21046333
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20854741
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20741002
98PHF8_20622854_ChIP-Seq_HELA_Human1.20229742
99MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20099754
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.18115510
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17827184
102FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17476217
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14772349
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14268837
105EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12896786
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12657229
107* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11997516
108E2F1_20622854_ChIP-Seq_HELA_Human1.11836815
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11350565
110MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11234627
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10823799
112TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10774154
113RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10691148
114CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08331238
115P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07360850
116CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06357009
117* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05967783
118GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05072069
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04715953
120TP63_17297297_ChIP-ChIP_HaCaT_Human1.03909354
121ETS1_20019798_ChIP-Seq_JURKAT_Human1.02903223
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02903103
123RARB_24833708_ChIP-Seq_LIVER_Mouse1.02530004
124SPI1_23127762_ChIP-Seq_K562_Human1.02106734
125KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01801933
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01791711
127* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01456027
128PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00624970
129MAF_26560356_Chip-Seq_TH2_Human1.00436827
130JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99697650
131ATF3_27146783_Chip-Seq_COLON_Human0.99425741
132* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99023355
133KDM2B_26808549_Chip-Seq_DND41_Human0.98915085
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98600648
135FOXP1_21924763_ChIP-Seq_HESCs_Human0.98185577
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98184539
137AR_21909140_ChIP-Seq_LNCAP_Human0.98105771
138PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97945582
139NCOR1_26117541_ChIP-Seq_K562_Human0.97887303
140PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97844470
141RUNX_20019798_ChIP-Seq_JUKART_Human0.96716456
142YY1_21170310_ChIP-Seq_MESCs_Mouse0.96343693
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96110140
144SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94370696
145THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94268364
146CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93984054
147PU_27001747_Chip-Seq_BMDM_Mouse0.93680463
148E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92309244
149E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91563264
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90933463
151GATA1_19941827_ChIP-Seq_MEL_Mouse0.90268252
152TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89242571
153GABP_19822575_ChIP-Seq_HepG2_Human0.88243067
154LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87414253
155XRN2_22483619_ChIP-Seq_HELA_Human0.86515204
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82081587
157NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81824168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.87867022
2MP0003111_abnormal_nucleus_morphology3.75481003
3MP0003705_abnormal_hypodermis_morpholog3.43399473
4MP0008057_abnormal_DNA_replication3.41242733
5MP0002396_abnormal_hematopoietic_system3.20522985
6MP0008058_abnormal_DNA_repair3.15871587
7MP0005058_abnormal_lysosome_morphology3.12954314
8MP0008877_abnormal_DNA_methylation3.05946897
9MP0003077_abnormal_cell_cycle2.67176564
10MP0008007_abnormal_cellular_replicative2.63670261
11MP0001986_abnormal_taste_sensitivity2.49545613
12MP0000015_abnormal_ear_pigmentation2.40902805
13MP0005174_abnormal_tail_pigmentation2.39280374
14MP0005410_abnormal_fertilization2.38276506
15MP0003693_abnormal_embryo_hatching2.32187350
16MP0004808_abnormal_hematopoietic_stem2.13229250
17MP0003172_abnormal_lysosome_physiology2.12078638
18MP0009278_abnormal_bone_marrow2.05766128
19MP0004185_abnormal_adipocyte_glucose2.04979542
20MP0003786_premature_aging2.04050969
21MP0001545_abnormal_hematopoietic_system2.04034246
22MP0005397_hematopoietic_system_phenotyp2.04034246
23MP0005451_abnormal_body_composition2.03742314
24MP0009840_abnormal_foam_cell2.01579991
25MP0010307_abnormal_tumor_latency1.97426330
26MP0002398_abnormal_bone_marrow1.93341192
27MP0000569_abnormal_digit_pigmentation1.92895337
28MP0001835_abnormal_antigen_presentation1.92211219
29MP0003763_abnormal_thymus_physiology1.88836250
30MP0005671_abnormal_response_to1.75607072
31MP0006292_abnormal_olfactory_placode1.73024924
32MP0001929_abnormal_gametogenesis1.71091200
33MP0004957_abnormal_blastocyst_morpholog1.67598386
34MP0000703_abnormal_thymus_morphology1.65816595
35MP0005083_abnormal_biliary_tract1.65631733
36MP0000685_abnormal_immune_system1.63725981
37MP0002210_abnormal_sex_determination1.63096970
38MP0000689_abnormal_spleen_morphology1.59835220
39MP0003787_abnormal_imprinting1.56757630
40MP0002249_abnormal_larynx_morphology1.55515341
41MP0008961_abnormal_basal_metabolism1.53999107
42MP0002722_abnormal_immune_system1.53709388
43MP0005075_abnormal_melanosome_morpholog1.53423161
44MP0000490_abnormal_crypts_of1.52394978
45MP0001800_abnormal_humoral_immune1.51471798
46MP0001661_extended_life_span1.51420178
47MP0002420_abnormal_adaptive_immunity1.49815242
48MP0001819_abnormal_immune_cell1.48398179
49MP0009333_abnormal_splenocyte_physiolog1.45596816
50MP0000716_abnormal_immune_system1.44961368
51MP0002452_abnormal_antigen_presenting1.44328120
52MP0002095_abnormal_skin_pigmentation1.42575516
53MP0005310_abnormal_salivary_gland1.42276628
54MP0000350_abnormal_cell_proliferation1.41152092
55MP0003698_abnormal_male_reproductive1.39002920
56MP0002970_abnormal_white_adipose1.36374725
57MP0001348_abnormal_lacrimal_gland1.35157441
58MP0008995_early_reproductive_senescence1.35020340
59MP0002723_abnormal_immune_serum1.32472199
60MP0004947_skin_inflammation1.32259134
61MP0002429_abnormal_blood_cell1.30548957
62MP0008260_abnormal_autophagy1.28665030
63MP0001145_abnormal_male_reproductive1.28472117
64MP0001849_ear_inflammation1.28409904
65MP0000003_abnormal_adipose_tissue1.27689315
66MP0000465_gastrointestinal_hemorrhage1.27482979
67MP0003183_abnormal_peptide_metabolism1.26001625
68MP0002009_preneoplasia1.25441928
69MP0003656_abnormal_erythrocyte_physiolo1.24322862
70MP0001873_stomach_inflammation1.22808372
71MP0002166_altered_tumor_susceptibility1.21507719
72MP0005387_immune_system_phenotype1.18989216
73MP0001790_abnormal_immune_system1.18989216
74MP0005380_embryogenesis_phenotype1.18756634
75MP0001672_abnormal_embryogenesis/_devel1.18756634
76MP0005409_darkened_coat_color1.17467657
77MP0003453_abnormal_keratinocyte_physiol1.17096625
78MP0002019_abnormal_tumor_incidence1.15698308
79MP0003984_embryonic_growth_retardation1.15614812
80MP0008932_abnormal_embryonic_tissue1.15213727
81MP0000313_abnormal_cell_death1.14399265
82MP0009931_abnormal_skin_appearance1.13258512
83MP0004858_abnormal_nervous_system1.12979653
84MP0002088_abnormal_embryonic_growth/wei1.11006433
85MP0005025_abnormal_response_to1.10515733
86MP0005000_abnormal_immune_tolerance1.09869443
87MP0001730_embryonic_growth_arrest1.09853936
88MP0000653_abnormal_sex_gland1.07177907
89MP0003091_abnormal_cell_migration1.07023669
90MP0003943_abnormal_hepatobiliary_system1.06227283
91MP0002419_abnormal_innate_immunity1.01012614
92MP0000428_abnormal_craniofacial_morphol1.00921402
93MP0003567_abnormal_fetal_cardiomyocyte1.00798052
94MP0002089_abnormal_postnatal_growth/wei1.00407851
95MP0001270_distended_abdomen0.99941765
96MP0004147_increased_porphyrin_level0.99751014
97MP0002075_abnormal_coat/hair_pigmentati0.99573812
98MP0005375_adipose_tissue_phenotype0.98137255
99MP0005621_abnormal_cell_physiology0.97046429
100MP0002877_abnormal_melanocyte_morpholog0.96286639
101MP0006054_spinal_hemorrhage0.95894044
102MP0005666_abnormal_adipose_tissue0.95803450
103MP0002006_tumorigenesis0.95350813
104MP0003121_genomic_imprinting0.95274953
105MP0003191_abnormal_cellular_cholesterol0.94706931
106MP0000733_abnormal_muscle_development0.93493720
107MP0002405_respiratory_system_inflammati0.93280220
108MP0003566_abnormal_cell_adhesion0.92485427
109MP0004233_abnormal_muscle_weight0.91516183
110MP0002086_abnormal_extraembryonic_tissu0.91163715
111MP0002138_abnormal_hepatobiliary_system0.90667538
112MP0004197_abnormal_fetal_growth/weight/0.89923677
113MP0002080_prenatal_lethality0.88924698
114MP0001697_abnormal_embryo_size0.88692475
115MP0005464_abnormal_platelet_physiology0.87989680
116MP0003123_paternal_imprinting0.87788544
117MP0002928_abnormal_bile_duct0.87487445
118MP0002925_abnormal_cardiovascular_devel0.86496781
119MP0003303_peritoneal_inflammation0.86322235
120MP0000858_altered_metastatic_potential0.85335833
121MP0009785_altered_susceptibility_to0.84457222
122MP0003866_abnormal_defecation0.84091094
123MP0003279_aneurysm0.84082471
124MP0002148_abnormal_hypersensitivity_rea0.83401756
125MP0005360_urolithiasis0.83220831
126MP0002160_abnormal_reproductive_system0.81195327
127MP0010630_abnormal_cardiac_muscle0.80286001
128MP0000371_diluted_coat_color0.79761067
129MP0002161_abnormal_fertility/fecundity0.79221059
130MP0002084_abnormal_developmental_patter0.78723858
131MP0003136_yellow_coat_color0.77964821
132MP0003300_gastrointestinal_ulcer0.77236085
133MP0003959_abnormal_lean_body0.77229318
134MP0009703_decreased_birth_body0.77148631
135MP0004381_abnormal_hair_follicle0.77126372
136MP0001119_abnormal_female_reproductive0.77081700
137MP0001188_hyperpigmentation0.73832361
138MP0010155_abnormal_intestine_physiology0.72751242
139MP0001186_pigmentation_phenotype0.72698731
140MP0005076_abnormal_cell_differentiation0.72336082
141MP0002085_abnormal_embryonic_tissue0.72010607
142MP0003828_pulmonary_edema0.71114928
143MP0003436_decreased_susceptibility_to0.69556794
144MP0001915_intracranial_hemorrhage0.68692149

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.87249378
2Chromsome breakage (HP:0040012)4.55444930
3Broad face (HP:0000283)3.76452435
4Abnormality of the fingertips (HP:0001211)3.64857942
5Abnormality of chromosome stability (HP:0003220)3.36560241
6Prostate neoplasm (HP:0100787)3.14183520
7Hemorrhage of the eye (HP:0011885)3.13745794
8Spinal cord lesions (HP:0100561)3.13252603
9Syringomyelia (HP:0003396)3.13252603
10Meckel diverticulum (HP:0002245)3.01204460
11Recurrent abscess formation (HP:0002722)2.99957290
12Ectopic kidney (HP:0000086)2.97961826
13Impulsivity (HP:0100710)2.95849036
14Ulnar bowing (HP:0003031)2.94785309
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.90428350
16Abnormality of the preputium (HP:0100587)2.89153757
17Abnormality of the ileum (HP:0001549)2.84076491
18Birth length less than 3rd percentile (HP:0003561)2.82578632
19Abnormality of DNA repair (HP:0003254)2.79603424
20Annular pancreas (HP:0001734)2.77214751
21Panhypogammaglobulinemia (HP:0003139)2.76805146
22Recurrent bacterial skin infections (HP:0005406)2.72124101
23Absent frontal sinuses (HP:0002688)2.71811167
24Facial hemangioma (HP:0000329)2.69929006
25Myelodysplasia (HP:0002863)2.67099058
26Recurrent viral infections (HP:0004429)2.62943044
27Thin bony cortex (HP:0002753)2.60975396
28Clubbing of toes (HP:0100760)2.60604119
29Abnormality of the thoracic spine (HP:0100711)2.59448881
30Colitis (HP:0002583)2.59051405
31Abnormality of the prostate (HP:0008775)2.48471121
32Duplicated collecting system (HP:0000081)2.46579949
33Poikiloderma (HP:0001029)2.43394516
34Abnormality of the carotid arteries (HP:0005344)2.42464944
35Disproportionate tall stature (HP:0001519)2.41806057
36Hyperacusis (HP:0010780)2.40181029
37Dynein arm defect of respiratory motile cilia (HP:0012255)2.39477430
38Absent/shortened dynein arms (HP:0200106)2.39477430
39Agnosia (HP:0010524)2.34351884
40Small intestinal stenosis (HP:0012848)2.34317446
41Duodenal stenosis (HP:0100867)2.34317446
42* Reticulocytosis (HP:0001923)2.31733576
43Recurrent fungal infections (HP:0002841)2.31431751
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.31234326
45Pointed chin (HP:0000307)2.29864973
46B lymphocytopenia (HP:0010976)2.29613857
47Abnormality of B cell number (HP:0010975)2.29613857
48Deep palmar crease (HP:0006191)2.27728770
49Cervical subluxation (HP:0003308)2.24859495
50Bone marrow hypocellularity (HP:0005528)2.23318043
51Rectal prolapse (HP:0002035)2.22751527
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21862944
53IgM deficiency (HP:0002850)2.21857570
54Overlapping toe (HP:0001845)2.21837552
55Thyroiditis (HP:0100646)2.20787247
56Thoracic kyphosis (HP:0002942)2.19762299
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19460661
58Prominent nose (HP:0000448)2.19022560
59Capillary hemangiomas (HP:0005306)2.18640656
60Metaphyseal dysplasia (HP:0100255)2.16364627
61Broad distal phalanx of finger (HP:0009836)2.15567387
62Supernumerary ribs (HP:0005815)2.15375699
63Nephroblastoma (Wilms tumor) (HP:0002667)2.14261244
64Obstructive lung disease (HP:0006536)2.14053924
65Chronic obstructive pulmonary disease (HP:0006510)2.14053924
66J-shaped sella turcica (HP:0002680)2.13508990
67Thin ribs (HP:0000883)2.12716677
68Sloping forehead (HP:0000340)2.10159471
69Squamous cell carcinoma (HP:0002860)2.09127661
70Meningitis (HP:0001287)2.08514042
71Acute myeloid leukemia (HP:0004808)2.07504635
72Abnormality of the renal collecting system (HP:0004742)2.06729642
73Abnormal spermatogenesis (HP:0008669)2.06182391
74Persistence of primary teeth (HP:0006335)2.06159177
75Pseudobulbar signs (HP:0002200)2.05254573
76Supernumerary bones of the axial skeleton (HP:0009144)2.03449200
77Mediastinal lymphadenopathy (HP:0100721)2.03031048
78IgG deficiency (HP:0004315)2.02122375
79Breast hypoplasia (HP:0003187)2.00118966
80Premature skin wrinkling (HP:0100678)1.99939900
81Truncus arteriosus (HP:0001660)1.99389639
82Flat cornea (HP:0007720)1.98047474
83Agammaglobulinemia (HP:0004432)1.97136638
84Dislocated radial head (HP:0003083)1.96083445
85Lymphoma (HP:0002665)1.95803308
86Insomnia (HP:0100785)1.94875670
87Renovascular hypertension (HP:0100817)1.94663916
88Cerebral aneurysm (HP:0004944)1.94271718
8911 pairs of ribs (HP:0000878)1.94233245
90Sandal gap (HP:0001852)1.94087518
91Embryonal renal neoplasm (HP:0011794)1.93395204
92Deformed sella turcica (HP:0002681)1.93394105
93Recurrent bronchitis (HP:0002837)1.93149459
94Broad palm (HP:0001169)1.91225440
95* Abnormality of reticulocytes (HP:0004312)1.91083104
96T lymphocytopenia (HP:0005403)1.90949618
97Recurrent cutaneous fungal infections (HP:0011370)1.90633621
98Chronic mucocutaneous candidiasis (HP:0002728)1.90633621
99Spina bifida occulta (HP:0003298)1.90470337
100Obstructive sleep apnea (HP:0002870)1.90122627
101Patellar dislocation (HP:0002999)1.89995276
102Medulloblastoma (HP:0002885)1.89694524
103Prominent metopic ridge (HP:0005487)1.88742646
104Mitral regurgitation (HP:0001653)1.88208784
105Abnormality of the aortic arch (HP:0012303)1.87088938
106Entropion (HP:0000621)1.86670101
107Patellar aplasia (HP:0006443)1.86317075
108Basal cell carcinoma (HP:0002671)1.86023771
109High pitched voice (HP:0001620)1.84987041
110Degeneration of anterior horn cells (HP:0002398)1.83431071
111Abnormality of the anterior horn cell (HP:0006802)1.83431071
112Abnormality of male internal genitalia (HP:0000022)1.83232019
113High anterior hairline (HP:0009890)1.82600899
114Cellulitis (HP:0100658)1.82310292
115Viral hepatitis (HP:0006562)1.81077923
116Short middle phalanx of the 5th finger (HP:0004220)1.80992837
117Gastrointestinal inflammation (HP:0004386)1.78922231
118Abnormality of the radial head (HP:0003995)1.78354626
119Prolonged bleeding time (HP:0003010)1.77013684
120Bowel incontinence (HP:0002607)1.76153409
121Sparse lateral eyebrow (HP:0005338)1.76121823
122Metaphyseal cupping (HP:0003021)1.75516135
123Absent thumb (HP:0009777)1.75270976
124Upper limb amyotrophy (HP:0009129)1.74638219
125Distal upper limb amyotrophy (HP:0007149)1.74638219
126Long eyelashes (HP:0000527)1.73985892
127Ureteral duplication (HP:0000073)1.73287672
128Hypertensive crisis (HP:0100735)1.73135594
129Acute lymphatic leukemia (HP:0006721)1.73133207
130Recurrent sinusitis (HP:0011108)1.73072302
131Cafe-au-lait spot (HP:0000957)1.72607747
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72383947
133Protruding tongue (HP:0010808)1.72072368
134Aplasia/Hypoplasia of the patella (HP:0006498)1.71814351
135Biconcave vertebral bodies (HP:0004586)1.71626345
136Heterotopia (HP:0002282)1.70973677
137Abnormality of lateral ventricle (HP:0030047)1.70945214
138Long palpebral fissure (HP:0000637)1.70514447
139Macroorchidism (HP:0000053)1.70419652
140Severe combined immunodeficiency (HP:0004430)1.70370041
141Easy fatigability (HP:0003388)1.69864406
142Abnormality of T cell number (HP:0011839)1.69804019
143Elfin facies (HP:0004428)1.69566577
144Short 4th metacarpal (HP:0010044)1.69265355
145Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69265355
146Nonimmune hydrops fetalis (HP:0001790)1.68916021
147Volvulus (HP:0002580)1.68650178
148Self-mutilation (HP:0000742)1.68616071
149Leukopenia (HP:0001882)1.67428388
150Recurrent skin infections (HP:0001581)1.67094784
151Abnormality of the metopic suture (HP:0005556)1.67093715
152Abnormality of T cells (HP:0002843)1.65935829
153Vertebral arch anomaly (HP:0008438)1.65576460
154Abnormality of the columella (HP:0009929)1.64690462
155Seborrheic dermatitis (HP:0001051)1.64595433
156Flared metaphyses (HP:0003015)1.64144602
157Abnormality of the duodenum (HP:0002246)1.63536029
158Slender long bone (HP:0003100)1.63496114
159Joint stiffness (HP:0001387)1.60839983
160Inflammation of the large intestine (HP:0002037)1.60370529
161Abnormal respiratory motile cilium morphology (HP:0005938)1.60152184
162Abnormal respiratory epithelium morphology (HP:0012253)1.60152184
163Truncal obesity (HP:0001956)1.60062689
164Abnormal large intestine physiology (HP:0012700)1.60017403
165Thrombocytosis (HP:0001894)1.59882978
166Aneurysm (HP:0002617)1.59573611
167Trigonocephaly (HP:0000243)1.58781218
168Increased connective tissue (HP:0009025)1.56697713
169Abnormality of the distal phalanx of the thumb (HP:0009617)1.55794177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.16156572
2NEK23.50902878
3CDK123.01244746
4MAP4K12.88038264
5CDC72.74705166
6MKNK22.60266289
7IRAK42.34370323
8SMG12.23583720
9MAP3K132.12888894
10WEE12.10623173
11SIK12.10466165
12CLK11.93152613
13MKNK11.92894770
14SRPK11.87050497
15EEF2K1.84776384
16TXK1.81384781
17BRD41.78269947
18ATR1.77822410
19YES11.77252160
20KSR21.69840080
21CAMK1D1.67699337
22CDK41.65563378
23STK41.65010739
24PKN21.63090782
25IRAK31.61977270
26JAK31.56888588
27PIM11.55316079
28FGFR41.55243312
29ERN11.51645522
30ICK1.48918797
31BUB11.46692090
32ZAP701.43943619
33MAP3K101.42777267
34RIPK41.41428264
35TNIK1.40393259
36ZAK1.37401409
37MAP2K21.30899707
38MARK21.28906593
39MAP3K141.28781304
40NLK1.28180438
41PLK41.27906605
42CDK71.27615224
43ACVR1B1.22342436
44TTN1.21028215
45CHEK21.20886208
46TSSK61.18673957
47PLK11.18345210
48MAPKAPK31.18007088
49BTK1.17886755
50TTK1.17424517
51CDK31.14970901
52RPS6KB21.13938603
53SGK21.12792360
54VRK11.12156528
55CSF1R1.10382626
56CAMK1G1.07643722
57KIT1.06488168
58IKBKB1.05029117
59CHEK11.04469526
60PRPF4B1.04313836
61MAP3K71.03001262
62CHUK1.01569981
63TESK20.99629959
64CCNB10.98551983
65RAF10.98395727
66CDC42BPA0.96812922
67ATM0.94043508
68CDK90.93610453
69CDK80.92284031
70TYRO30.91790453
71AURKB0.91278721
72SGK30.90426222
73DYRK30.90151947
74CDK60.90150822
75HIPK20.89459231
76PDK30.88261821
77PDK40.88261821
78SIK20.85494015
79IRAK10.84482425
80SYK0.83513818
81PTK60.83346374
82STK100.81499108
83EPHB10.80673155
84STK30.79926280
85TBK10.78390505
86GRK60.77576477
87MAP2K30.76725659
88RPS6KA60.76411670
89ALK0.76161696
90BLK0.75147504
91CDK20.74979278
92TLK10.73991448
93TYK20.73576340
94MAPK120.72985288
95LCK0.72340722
96PRKD20.71741356
97RPS6KL10.71636466
98RPS6KC10.71636466
99KSR10.71556072
100PDPK10.71509331
101MAP3K10.71225282
102TAOK10.71139939
103RPS6KA40.70393526
104TNK20.69300197
105BRSK20.69226677
106HCK0.68597215
107PRKD30.68354766
108IKBKE0.67991667
109TEC0.67859080
110EIF2AK30.66999500
111EIF2AK20.66235887
112RPS6KB10.65168932
113RET0.63893509
114STK380.63880942
115CDK10.61260505
116ITK0.60359036
117BMX0.59839043
118MAP3K80.59444305
119TAOK30.59207278
120FGFR30.56128744
121RPS6KA10.54363971
122FES0.53932199
123STK110.53523157
124CSK0.53310463
125LYN0.52485145
126PDK10.51513495
127BRSK10.51149243
128TRPM70.50115656
129MTOR0.50008565
130AKT30.49606753
131MAP2K10.49126309
132MAPK150.48350428
133MAP2K60.47688540
134MUSK0.47157280
135MELK0.47123114
136WNK10.47032795
137MARK30.46966193
138PLK30.46107627
139JAK20.43324442
140PRKAA10.43233204
141MAPK110.43145038
142PNCK0.42797010
143MAPK140.42344810
144JAK10.42143980
145PDGFRA0.42012510
146CAMKK10.41806909
147MAP3K60.41100075
148WNK40.41052317
149RPS6KA20.39253604
150PRKCH0.39104576
151MAPK10.39053891
152MAPK70.38179397
153CASK0.37398309

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.47305968
2Fanconi anemia pathway_Homo sapiens_hsa034603.10227992
3Homologous recombination_Homo sapiens_hsa034402.60879400
4Base excision repair_Homo sapiens_hsa034102.52689431
5Mismatch repair_Homo sapiens_hsa034302.45139232
6Spliceosome_Homo sapiens_hsa030402.14777580
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14443588
8mRNA surveillance pathway_Homo sapiens_hsa030152.11088147
9Nucleotide excision repair_Homo sapiens_hsa034202.07008711
10Cell cycle_Homo sapiens_hsa041102.05089996
11Primary immunodeficiency_Homo sapiens_hsa053401.98313617
12RNA transport_Homo sapiens_hsa030131.93737377
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.88339524
14Non-homologous end-joining_Homo sapiens_hsa034501.81672071
15Vitamin B6 metabolism_Homo sapiens_hsa007501.80674859
16VEGF signaling pathway_Homo sapiens_hsa043701.72854130
17Basal transcription factors_Homo sapiens_hsa030221.72523928
18Herpes simplex infection_Homo sapiens_hsa051681.69146276
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.66116809
20Measles_Homo sapiens_hsa051621.62074670
21RNA polymerase_Homo sapiens_hsa030201.60422673
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.59161869
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49623562
24Antigen processing and presentation_Homo sapiens_hsa046121.46475188
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43309372
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.38583820
27B cell receptor signaling pathway_Homo sapiens_hsa046621.34466736
28Bladder cancer_Homo sapiens_hsa052191.31484970
29Sulfur relay system_Homo sapiens_hsa041221.28774076
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.28538032
31p53 signaling pathway_Homo sapiens_hsa041151.25693158
32RNA degradation_Homo sapiens_hsa030181.23558456
33Leishmaniasis_Homo sapiens_hsa051401.21361588
34Pyrimidine metabolism_Homo sapiens_hsa002401.20040303
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19862002
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19164660
37Choline metabolism in cancer_Homo sapiens_hsa052311.18298678
38Epstein-Barr virus infection_Homo sapiens_hsa051691.15193051
39Glioma_Homo sapiens_hsa052141.14959650
40Influenza A_Homo sapiens_hsa051641.13678968
41ErbB signaling pathway_Homo sapiens_hsa040121.12995698
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12575217
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10291307
44Hematopoietic cell lineage_Homo sapiens_hsa046401.07296570
45T cell receptor signaling pathway_Homo sapiens_hsa046601.06374424
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06023286
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.04849099
48Acute myeloid leukemia_Homo sapiens_hsa052211.01411437
49Osteoclast differentiation_Homo sapiens_hsa043801.00666370
50ABC transporters_Homo sapiens_hsa020100.99680407
51HTLV-I infection_Homo sapiens_hsa051660.98782435
52Small cell lung cancer_Homo sapiens_hsa052220.97863957
53Notch signaling pathway_Homo sapiens_hsa043300.97846973
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97247294
55Graft-versus-host disease_Homo sapiens_hsa053320.96988933
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.94895160
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.94250563
58Chronic myeloid leukemia_Homo sapiens_hsa052200.91105915
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91064549
60Viral carcinogenesis_Homo sapiens_hsa052030.90784088
61Renal cell carcinoma_Homo sapiens_hsa052110.89222082
62Insulin resistance_Homo sapiens_hsa049310.86444328
63Hepatitis B_Homo sapiens_hsa051610.85920968
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.85862262
65Systemic lupus erythematosus_Homo sapiens_hsa053220.85513847
66Purine metabolism_Homo sapiens_hsa002300.83632252
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83598487
68GnRH signaling pathway_Homo sapiens_hsa049120.82752359
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82700553
70MicroRNAs in cancer_Homo sapiens_hsa052060.82036784
71Toxoplasmosis_Homo sapiens_hsa051450.81571463
72Oocyte meiosis_Homo sapiens_hsa041140.81220575
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80256888
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78768365
75Inositol phosphate metabolism_Homo sapiens_hsa005620.77445448
76Apoptosis_Homo sapiens_hsa042100.76341199
77Estrogen signaling pathway_Homo sapiens_hsa049150.73812923
78Lysine degradation_Homo sapiens_hsa003100.73317928
79Focal adhesion_Homo sapiens_hsa045100.73152530
80AMPK signaling pathway_Homo sapiens_hsa041520.72875418
81Chemokine signaling pathway_Homo sapiens_hsa040620.71885968
82Prostate cancer_Homo sapiens_hsa052150.70887255
83Pentose phosphate pathway_Homo sapiens_hsa000300.70133447
84Insulin signaling pathway_Homo sapiens_hsa049100.69967252
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68210476
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67584591
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65786702
88Shigellosis_Homo sapiens_hsa051310.65715727
89Legionellosis_Homo sapiens_hsa051340.64610171
90Tuberculosis_Homo sapiens_hsa051520.64498602
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63915718
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.62970122
93Platelet activation_Homo sapiens_hsa046110.62961862
94Thyroid cancer_Homo sapiens_hsa052160.62549363
95Viral myocarditis_Homo sapiens_hsa054160.61931349
96Prion diseases_Homo sapiens_hsa050200.61017874
97Phototransduction_Homo sapiens_hsa047440.59678520
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57879648
99Colorectal cancer_Homo sapiens_hsa052100.57157218
100One carbon pool by folate_Homo sapiens_hsa006700.56703989
101Proteoglycans in cancer_Homo sapiens_hsa052050.56543834
102Ovarian steroidogenesis_Homo sapiens_hsa049130.55925916
103TNF signaling pathway_Homo sapiens_hsa046680.55261656
104Basal cell carcinoma_Homo sapiens_hsa052170.55187720
105Non-small cell lung cancer_Homo sapiens_hsa052230.54905984
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54679374
107Endometrial cancer_Homo sapiens_hsa052130.54374528
108Salmonella infection_Homo sapiens_hsa051320.52309923
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52171900
110Melanoma_Homo sapiens_hsa052180.51365456
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50737777
112FoxO signaling pathway_Homo sapiens_hsa040680.49154530
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49051823
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.48009928
115HIF-1 signaling pathway_Homo sapiens_hsa040660.47858463
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45259437
117Pancreatic cancer_Homo sapiens_hsa052120.44706661
118Dorso-ventral axis formation_Homo sapiens_hsa043200.43605078
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42951350
120Pathways in cancer_Homo sapiens_hsa052000.42899966
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.41567420
122Allograft rejection_Homo sapiens_hsa053300.40491187
123Asthma_Homo sapiens_hsa053100.40443628
124MAPK signaling pathway_Homo sapiens_hsa040100.40160718
125mTOR signaling pathway_Homo sapiens_hsa041500.39759991
126Other glycan degradation_Homo sapiens_hsa005110.39476066
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39058686
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39009746
129Wnt signaling pathway_Homo sapiens_hsa043100.37942148
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37732127
131Prolactin signaling pathway_Homo sapiens_hsa049170.37504428
132Hepatitis C_Homo sapiens_hsa051600.35988479
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35892306
134Alcoholism_Homo sapiens_hsa050340.34408143

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