Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.69126970 |
2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.23707315 |
3 | ATP synthesis coupled proton transport (GO:0015986) | 6.23707315 |
4 | cullin deneddylation (GO:0010388) | 5.09007942 |
5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.81958602 |
6 | ribosomal small subunit assembly (GO:0000028) | 4.80955485 |
7 | viral transcription (GO:0019083) | 4.69861895 |
8 | protein deneddylation (GO:0000338) | 4.69674549 |
9 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.65436592 |
10 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.65436592 |
11 | NADH dehydrogenase complex assembly (GO:0010257) | 4.65436592 |
12 | translational termination (GO:0006415) | 4.61662936 |
13 | ribosomal small subunit biogenesis (GO:0042274) | 4.58934479 |
14 | proteasome assembly (GO:0043248) | 4.53193324 |
15 | protein neddylation (GO:0045116) | 4.52808800 |
16 | cotranslational protein targeting to membrane (GO:0006613) | 4.50311116 |
17 | respiratory electron transport chain (GO:0022904) | 4.49047750 |
18 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.44554682 |
19 | ribosome assembly (GO:0042255) | 4.43950135 |
20 | protein targeting to ER (GO:0045047) | 4.39475781 |
21 | electron transport chain (GO:0022900) | 4.38530859 |
22 | protein complex biogenesis (GO:0070271) | 4.34532603 |
23 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 4.28270587 |
24 | protein localization to endoplasmic reticulum (GO:0070972) | 4.23024955 |
25 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.18316575 |
26 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.17970390 |
27 | IMP biosynthetic process (GO:0006188) | 4.15310477 |
28 | chaperone-mediated protein transport (GO:0072321) | 4.14897019 |
29 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.12002514 |
30 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.11814321 |
31 | purine nucleobase biosynthetic process (GO:0009113) | 4.08130746 |
32 | DNA replication checkpoint (GO:0000076) | 4.07469206 |
33 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.03941026 |
34 | translational elongation (GO:0006414) | 4.00495609 |
35 | establishment of integrated proviral latency (GO:0075713) | 3.97162263 |
36 | DNA strand elongation (GO:0022616) | 3.93898288 |
37 | mitotic metaphase plate congression (GO:0007080) | 3.93224985 |
38 | negative regulation of ligase activity (GO:0051352) | 3.88194352 |
39 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.88194352 |
40 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.82700515 |
41 | cellular protein complex disassembly (GO:0043624) | 3.82028953 |
42 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.81695643 |
43 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.81695643 |
44 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.81509405 |
45 | nucleobase biosynthetic process (GO:0046112) | 3.79355137 |
46 | maturation of SSU-rRNA (GO:0030490) | 3.79319018 |
47 | histone exchange (GO:0043486) | 3.75662575 |
48 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.75448433 |
49 | translation (GO:0006412) | 3.73352486 |
50 | rRNA modification (GO:0000154) | 3.70547435 |
51 | translational initiation (GO:0006413) | 3.70331107 |
52 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.69438990 |
53 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.68378691 |
54 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.68378691 |
55 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.66970312 |
56 | protein localization to kinetochore (GO:0034501) | 3.65721652 |
57 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.64995162 |
58 | viral life cycle (GO:0019058) | 3.63838727 |
59 | DNA double-strand break processing (GO:0000729) | 3.62310108 |
60 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.61942665 |
61 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.61942665 |
62 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.61942665 |
63 | ribosomal large subunit biogenesis (GO:0042273) | 3.59940756 |
64 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.58543558 |
65 | IMP metabolic process (GO:0046040) | 3.58187514 |
66 | DNA deamination (GO:0045006) | 3.57961647 |
67 | telomere maintenance via recombination (GO:0000722) | 3.57062781 |
68 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.56272810 |
69 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.56272810 |
70 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.53629903 |
71 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.52594466 |
72 | metaphase plate congression (GO:0051310) | 3.52433454 |
73 | spliceosomal snRNP assembly (GO:0000387) | 3.51841248 |
74 | establishment of viral latency (GO:0019043) | 3.51031121 |
75 | DNA replication-independent nucleosome organization (GO:0034724) | 3.49564854 |
76 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.49564854 |
77 | DNA ligation (GO:0006266) | 3.49486757 |
78 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.46786098 |
79 | non-recombinational repair (GO:0000726) | 3.45850383 |
80 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.45850383 |
81 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.44764392 |
82 | maturation of 5.8S rRNA (GO:0000460) | 3.43880943 |
83 | termination of RNA polymerase III transcription (GO:0006386) | 3.43800217 |
84 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.43800217 |
85 | spliceosomal complex assembly (GO:0000245) | 3.43645640 |
86 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.41845544 |
87 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.41835203 |
88 | regulation of ligase activity (GO:0051340) | 3.41808111 |
89 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.37192183 |
90 | mitotic recombination (GO:0006312) | 3.35968708 |
91 | DNA replication initiation (GO:0006270) | 3.35032592 |
92 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.32306229 |
93 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.32306229 |
94 | DNA damage response, detection of DNA damage (GO:0042769) | 3.28896605 |
95 | regulation of helicase activity (GO:0051095) | 3.28131629 |
96 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.27605648 |
97 | protein targeting to mitochondrion (GO:0006626) | 3.27234827 |
98 | spindle checkpoint (GO:0031577) | 3.26531457 |
99 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.25947502 |
100 | cell cycle G1/S phase transition (GO:0044843) | 3.25947502 |
101 | protein complex disassembly (GO:0043241) | 3.24620542 |
102 | establishment of protein localization to mitochondrion (GO:0072655) | 3.23606022 |
103 | CENP-A containing nucleosome assembly (GO:0034080) | 3.22913344 |
104 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.22396722 |
105 | rRNA processing (GO:0006364) | 3.21350148 |
106 | mitotic sister chromatid segregation (GO:0000070) | 3.21117663 |
107 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.20898485 |
108 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.19826110 |
109 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.19826110 |
110 | negative regulation of sister chromatid segregation (GO:0033046) | 3.19826110 |
111 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.19826110 |
112 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.19826110 |
113 | GTP biosynthetic process (GO:0006183) | 3.19783492 |
114 | formation of translation preinitiation complex (GO:0001731) | 3.19713283 |
115 | mitotic spindle checkpoint (GO:0071174) | 3.19618971 |
116 | negative regulation of chromosome segregation (GO:0051985) | 3.18392217 |
117 | oxidative phosphorylation (GO:0006119) | 3.17466057 |
118 | amino acid salvage (GO:0043102) | 3.15098905 |
119 | L-methionine salvage (GO:0071267) | 3.15098905 |
120 | L-methionine biosynthetic process (GO:0071265) | 3.15098905 |
121 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.14488769 |
122 | fatty acid elongation (GO:0030497) | 3.14451635 |
123 | 7-methylguanosine RNA capping (GO:0009452) | 3.13865699 |
124 | RNA capping (GO:0036260) | 3.13865699 |
125 | macromolecular complex disassembly (GO:0032984) | 3.13799761 |
126 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.13052801 |
127 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.13052801 |
128 | DNA unwinding involved in DNA replication (GO:0006268) | 3.12747035 |
129 | tRNA aminoacylation for protein translation (GO:0006418) | 3.12507049 |
130 | 7-methylguanosine mRNA capping (GO:0006370) | 3.11604046 |
131 | positive regulation of ligase activity (GO:0051351) | 3.10811630 |
132 | amino acid activation (GO:0043038) | 3.10541448 |
133 | tRNA aminoacylation (GO:0043039) | 3.10541448 |
134 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.09266917 |
135 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.09266917 |
136 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.08598399 |
137 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.08408819 |
138 | telomere maintenance via telomere lengthening (GO:0010833) | 3.07958474 |
139 | rRNA metabolic process (GO:0016072) | 3.07292302 |
140 | chromatin remodeling at centromere (GO:0031055) | 3.07125175 |
141 | regulation of mitochondrial translation (GO:0070129) | 3.07019091 |
142 | cellular component biogenesis (GO:0044085) | 3.06624190 |
143 | negative regulation of protein ubiquitination (GO:0031397) | 3.06474302 |
144 | inner mitochondrial membrane organization (GO:0007007) | 3.05084351 |
145 | rRNA methylation (GO:0031167) | 3.04748453 |
146 | protein localization to mitochondrion (GO:0070585) | 3.04645744 |
147 | pseudouridine synthesis (GO:0001522) | 3.03983347 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.16268664 |
2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.08709512 |
3 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.36581203 |
4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.28922940 |
5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.23938945 |
6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.11701110 |
7 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.67601755 |
8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.66296375 |
9 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.56059427 |
10 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.55844059 |
11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.52810588 |
12 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.46869487 |
13 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.15840225 |
14 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.12437507 |
15 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.99062001 |
16 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.92040197 |
17 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.78695277 |
18 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.68894085 |
19 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.67033640 |
20 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.65870217 |
21 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.55211645 |
22 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.52478599 |
23 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.48842142 |
24 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.34127636 |
25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.31319209 |
26 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.28277500 |
27 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.27100777 |
28 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.26035206 |
29 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.24815182 |
30 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.20965134 |
31 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.16020339 |
32 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.14039467 |
33 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.11807914 |
34 | * TTF2_22483619_ChIP-Seq_HELA_Human | 2.09432091 |
35 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.05413928 |
36 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.97481269 |
37 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.93916327 |
38 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.93817222 |
39 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.87413867 |
40 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.84298424 |
41 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.81522103 |
42 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.73132014 |
43 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.64709667 |
44 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.64347664 |
45 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.52404664 |
46 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.51812411 |
47 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.51505737 |
48 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.46857504 |
49 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.45214781 |
50 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.43738082 |
51 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.38701923 |
52 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.38335523 |
53 | FUS_26573619_Chip-Seq_HEK293_Human | 1.37284896 |
54 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.37009548 |
55 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.36688181 |
56 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.35364213 |
57 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.34668586 |
58 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.31642880 |
59 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.28429437 |
60 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.28192705 |
61 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.27072800 |
62 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.27011527 |
63 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.21867423 |
64 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.21316205 |
65 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.17903869 |
66 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.17795687 |
67 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.12913607 |
68 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.11189289 |
69 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.09810514 |
70 | EWS_26573619_Chip-Seq_HEK293_Human | 1.09596196 |
71 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.07336235 |
72 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.06673063 |
73 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.06243966 |
74 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05495494 |
75 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.03794545 |
76 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.00653990 |
77 | VDR_22108803_ChIP-Seq_LS180_Human | 0.97907059 |
78 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.97902471 |
79 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.95970850 |
80 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.95895443 |
81 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.94253852 |
82 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.93840111 |
83 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.93827415 |
84 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.92891375 |
85 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.91181434 |
86 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.90484255 |
87 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.89443880 |
88 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.89031651 |
89 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.88983108 |
90 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.88837949 |
91 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.86887146 |
92 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.86003454 |
93 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.84393463 |
94 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.84105855 |
95 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.78473178 |
96 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.77023710 |
97 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.76708727 |
98 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.74364706 |
99 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.73721673 |
100 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.73518090 |
101 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.73376403 |
102 | * CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.71007424 |
103 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.70605389 |
104 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.69415073 |
105 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.69278666 |
106 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.67721212 |
107 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.67580096 |
108 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.67061002 |
109 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.66916588 |
110 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.65823735 |
111 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.64383362 |
112 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.64142875 |
113 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.64128112 |
114 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.63846605 |
115 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.63601431 |
116 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.62603488 |
117 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.62071777 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0001529_abnormal_vocalization | 4.24645608 |
2 | MP0009379_abnormal_foot_pigmentation | 3.48058686 |
3 | MP0000566_synostosis | 3.21169111 |
4 | MP0003880_abnormal_central_pattern | 3.16519725 |
5 | MP0004957_abnormal_blastocyst_morpholog | 2.92523763 |
6 | MP0008057_abnormal_DNA_replication | 2.86794672 |
7 | MP0010094_abnormal_chromosome_stability | 2.73047363 |
8 | MP0008932_abnormal_embryonic_tissue | 2.63353711 |
9 | MP0003122_maternal_imprinting | 2.59183015 |
10 | MP0003693_abnormal_embryo_hatching | 2.56309798 |
11 | MP0003941_abnormal_skin_development | 2.53317484 |
12 | MP0001905_abnormal_dopamine_level | 2.48808771 |
13 | MP0003123_paternal_imprinting | 2.33597323 |
14 | MP0008058_abnormal_DNA_repair | 2.22140860 |
15 | MP0003077_abnormal_cell_cycle | 2.00447795 |
16 | MP0002102_abnormal_ear_morphology | 1.96535567 |
17 | MP0003121_genomic_imprinting | 1.95762449 |
18 | MP0002938_white_spotting | 1.88143505 |
19 | MP0004147_increased_porphyrin_level | 1.75778689 |
20 | MP0003806_abnormal_nucleotide_metabolis | 1.69748361 |
21 | MP0003111_abnormal_nucleus_morphology | 1.68734324 |
22 | MP0004142_abnormal_muscle_tone | 1.68330436 |
23 | MP0002163_abnormal_gland_morphology | 1.67013325 |
24 | MP0008789_abnormal_olfactory_epithelium | 1.66326348 |
25 | MP0006276_abnormal_autonomic_nervous | 1.65480799 |
26 | MP0002736_abnormal_nociception_after | 1.61572434 |
27 | MP0008877_abnormal_DNA_methylation | 1.57691894 |
28 | MP0006036_abnormal_mitochondrial_physio | 1.52230981 |
29 | MP0003567_abnormal_fetal_cardiomyocyte | 1.50515909 |
30 | MP0010030_abnormal_orbit_morphology | 1.47761466 |
31 | MP0001188_hyperpigmentation | 1.44808430 |
32 | MP0000358_abnormal_cell_content/ | 1.44202906 |
33 | MP0005380_embryogenesis_phenotype | 1.44038668 |
34 | MP0001672_abnormal_embryogenesis/_devel | 1.44038668 |
35 | MP0000537_abnormal_urethra_morphology | 1.42324160 |
36 | MP0006035_abnormal_mitochondrial_morpho | 1.41778791 |
37 | MP0002751_abnormal_autonomic_nervous | 1.39632867 |
38 | MP0008007_abnormal_cellular_replicative | 1.37127112 |
39 | MP0006292_abnormal_olfactory_placode | 1.36892377 |
40 | MP0005171_absent_coat_pigmentation | 1.36850268 |
41 | MP0000313_abnormal_cell_death | 1.35960563 |
42 | MP0002080_prenatal_lethality | 1.35785181 |
43 | MP0006054_spinal_hemorrhage | 1.34752655 |
44 | MP0002085_abnormal_embryonic_tissue | 1.30987015 |
45 | MP0005394_taste/olfaction_phenotype | 1.30514708 |
46 | MP0005499_abnormal_olfactory_system | 1.30514708 |
47 | MP0010352_gastrointestinal_tract_polyps | 1.29606265 |
48 | MP0002272_abnormal_nervous_system | 1.29266255 |
49 | MP0003787_abnormal_imprinting | 1.29226786 |
50 | MP0002638_abnormal_pupillary_reflex | 1.28917695 |
51 | MP0010307_abnormal_tumor_latency | 1.26817593 |
52 | MP0009697_abnormal_copulation | 1.25752538 |
53 | MP0000631_abnormal_neuroendocrine_gland | 1.25281407 |
54 | MP0001968_abnormal_touch/_nociception | 1.24566592 |
55 | MP0002084_abnormal_developmental_patter | 1.24379086 |
56 | MP0003186_abnormal_redox_activity | 1.24096309 |
57 | MP0004133_heterotaxia | 1.18264201 |
58 | MP0000049_abnormal_middle_ear | 1.17685676 |
59 | MP0006072_abnormal_retinal_apoptosis | 1.15879221 |
60 | MP0009672_abnormal_birth_weight | 1.15440867 |
61 | MP0003984_embryonic_growth_retardation | 1.14569001 |
62 | MP0002396_abnormal_hematopoietic_system | 1.13101190 |
63 | MP0002088_abnormal_embryonic_growth/wei | 1.11904839 |
64 | MP0001485_abnormal_pinna_reflex | 1.11457351 |
65 | MP0002064_seizures | 1.11313389 |
66 | MP0005646_abnormal_pituitary_gland | 1.10139243 |
67 | MP0009046_muscle_twitch | 1.09689149 |
68 | MP0002210_abnormal_sex_determination | 1.09026619 |
69 | MP0004134_abnormal_chest_morphology | 1.08407805 |
70 | MP0005408_hypopigmentation | 1.05569456 |
71 | MP0005386_behavior/neurological_phenoty | 1.05424984 |
72 | MP0004924_abnormal_behavior | 1.05424984 |
73 | MP0001929_abnormal_gametogenesis | 1.04765851 |
74 | MP0005409_darkened_coat_color | 1.04746421 |
75 | MP0000778_abnormal_nervous_system | 1.04585465 |
76 | MP0002019_abnormal_tumor_incidence | 1.03717542 |
77 | MP0003937_abnormal_limbs/digits/tail_de | 1.03558213 |
78 | MP0003315_abnormal_perineum_morphology | 1.02311202 |
79 | MP0008004_abnormal_stomach_pH | 1.01910021 |
80 | MP0003938_abnormal_ear_development | 1.01656224 |
81 | MP0002254_reproductive_system_inflammat | 1.01591076 |
82 | MP0002734_abnormal_mechanical_nocicepti | 1.01205572 |
83 | MP0005503_abnormal_tendon_morphology | 1.00807334 |
84 | MP0005379_endocrine/exocrine_gland_phen | 0.99041687 |
85 | MP0005084_abnormal_gallbladder_morpholo | 0.98837024 |
86 | MP0000372_irregular_coat_pigmentation | 0.96500079 |
87 | MP0009745_abnormal_behavioral_response | 0.94679528 |
88 | MP0003656_abnormal_erythrocyte_physiolo | 0.94288915 |
89 | MP0000026_abnormal_inner_ear | 0.92259633 |
90 | MP0002233_abnormal_nose_morphology | 0.92242412 |
91 | MP0001286_abnormal_eye_development | 0.91785541 |
92 | MP0001145_abnormal_male_reproductive | 0.90827728 |
93 | MP0002572_abnormal_emotion/affect_behav | 0.90521663 |
94 | MP0003718_maternal_effect | 0.90221449 |
95 | MP0000920_abnormal_myelination | 0.90017195 |
96 | MP0000653_abnormal_sex_gland | 0.86957330 |
97 | MP0009250_abnormal_appendicular_skeleto | 0.86180070 |
98 | MP0000647_abnormal_sebaceous_gland | 0.85939939 |
99 | MP0008995_early_reproductive_senescence | 0.84355180 |
100 | MP0002876_abnormal_thyroid_physiology | 0.84346470 |
101 | MP0005395_other_phenotype | 0.84195712 |
102 | MP0000490_abnormal_crypts_of | 0.84144904 |
103 | MP0003950_abnormal_plasma_membrane | 0.82992818 |
104 | MP0001986_abnormal_taste_sensitivity | 0.82420225 |
105 | MP0003786_premature_aging | 0.81768043 |
106 | MP0003221_abnormal_cardiomyocyte_apopto | 0.81525682 |
107 | MP0003136_yellow_coat_color | 0.81509139 |
108 | MP0000350_abnormal_cell_proliferation | 0.80949657 |
109 | MP0002111_abnormal_tail_morphology | 0.79775990 |
110 | MP0002086_abnormal_extraembryonic_tissu | 0.78442969 |
111 | MP0002277_abnormal_respiratory_mucosa | 0.77957496 |
112 | MP0004197_abnormal_fetal_growth/weight/ | 0.77660968 |
113 | MP0005551_abnormal_eye_electrophysiolog | 0.77605272 |
114 | MP0001730_embryonic_growth_arrest | 0.77090965 |
115 | MP0003119_abnormal_digestive_system | 0.76482263 |
116 | MP0002067_abnormal_sensory_capabilities | 0.75950939 |
117 | MP0005075_abnormal_melanosome_morpholog | 0.75215511 |
118 | MP0002837_dystrophic_cardiac_calcinosis | 0.74923047 |
119 | MP0002697_abnormal_eye_size | 0.74902889 |
120 | MP0002282_abnormal_trachea_morphology | 0.74239415 |
121 | MP0001727_abnormal_embryo_implantation | 0.72858878 |
122 | MP0002160_abnormal_reproductive_system | 0.71301378 |
123 | MP0001119_abnormal_female_reproductive | 0.71106452 |
124 | MP0002090_abnormal_vision | 0.70523458 |
125 | MP0001853_heart_inflammation | 0.70458691 |
126 | MP0005266_abnormal_metabolism | 0.70144763 |
127 | MP0002184_abnormal_innervation | 0.69588255 |
128 | MP0004742_abnormal_vestibular_system | 0.68845755 |
129 | MP0003635_abnormal_synaptic_transmissio | 0.68319538 |
130 | MP0002735_abnormal_chemical_nociception | 0.68143908 |
131 | MP0001764_abnormal_homeostasis | 0.68097942 |
132 | MP0005253_abnormal_eye_physiology | 0.68027857 |
133 | MP0001963_abnormal_hearing_physiology | 0.67775498 |
134 | MP0001697_abnormal_embryo_size | 0.67617118 |
135 | MP0000762_abnormal_tongue_morphology | 0.67506191 |
136 | MP0002752_abnormal_somatic_nervous | 0.67451966 |
137 | MP0001293_anophthalmia | 0.67301316 |
138 | MP0005645_abnormal_hypothalamus_physiol | 0.66783627 |
139 | MP0003890_abnormal_embryonic-extraembry | 0.66398516 |
140 | MP0008873_increased_physiological_sensi | 0.66124233 |
141 | MP0001881_abnormal_mammary_gland | 0.62132882 |
142 | MP0005384_cellular_phenotype | 0.61098034 |
143 | MP0004215_abnormal_myocardial_fiber | 0.60428796 |
144 | MP0005389_reproductive_system_phenotype | 0.57134119 |
145 | MP0009703_decreased_birth_body | 0.56885893 |
146 | MP0002234_abnormal_pharynx_morphology | 0.56869323 |
147 | MP0005501_abnormal_skin_physiology | 0.56458715 |
148 | MP0005391_vision/eye_phenotype | 0.53483272 |
149 | MP0002796_impaired_skin_barrier | 0.53466930 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 6.61430920 |
2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 6.07144968 |
3 | Mitochondrial inheritance (HP:0001427) | 5.79006981 |
4 | Increased serum pyruvate (HP:0003542) | 5.35115872 |
5 | Abnormality of glycolysis (HP:0004366) | 5.35115872 |
6 | Progressive macrocephaly (HP:0004481) | 5.33084229 |
7 | Acute encephalopathy (HP:0006846) | 5.30169759 |
8 | Hepatocellular necrosis (HP:0001404) | 5.15600710 |
9 | Increased CSF lactate (HP:0002490) | 5.07853456 |
10 | Increased hepatocellular lipid droplets (HP:0006565) | 4.48991297 |
11 | Hepatic necrosis (HP:0002605) | 4.34986196 |
12 | Lipid accumulation in hepatocytes (HP:0006561) | 4.00751938 |
13 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.86291382 |
14 | Abnormal number of erythroid precursors (HP:0012131) | 3.76771617 |
15 | Leukodystrophy (HP:0002415) | 3.74285911 |
16 | 3-Methylglutaconic aciduria (HP:0003535) | 3.67159513 |
17 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.62306774 |
18 | Renal Fanconi syndrome (HP:0001994) | 3.58386914 |
19 | Respiratory failure (HP:0002878) | 3.56079763 |
20 | Increased serum lactate (HP:0002151) | 3.55558672 |
21 | Cerebral hypomyelination (HP:0006808) | 3.53754177 |
22 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.45841179 |
23 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.45841179 |
24 | Chromsome breakage (HP:0040012) | 3.45745906 |
25 | Exercise intolerance (HP:0003546) | 3.45076528 |
26 | Reticulocytopenia (HP:0001896) | 3.43765145 |
27 | Cerebral edema (HP:0002181) | 3.41652505 |
28 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.39181493 |
29 | Optic disc pallor (HP:0000543) | 3.30224351 |
30 | Meckel diverticulum (HP:0002245) | 3.21521364 |
31 | Lactic acidosis (HP:0003128) | 3.20697866 |
32 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.15234786 |
33 | Increased intramyocellular lipid droplets (HP:0012240) | 3.12070137 |
34 | Abnormality of the ileum (HP:0001549) | 3.03878721 |
35 | Macrocytic anemia (HP:0001972) | 3.02832671 |
36 | Abnormality of methionine metabolism (HP:0010901) | 2.96576393 |
37 | Abnormality of the preputium (HP:0100587) | 2.94267375 |
38 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.92168180 |
39 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.88563080 |
40 | Exertional dyspnea (HP:0002875) | 2.88355570 |
41 | Abnormality of chromosome stability (HP:0003220) | 2.84626141 |
42 | Multiple enchondromatosis (HP:0005701) | 2.82702006 |
43 | Birth length less than 3rd percentile (HP:0003561) | 2.77271158 |
44 | Neuroendocrine neoplasm (HP:0100634) | 2.65557700 |
45 | Reduced antithrombin III activity (HP:0001976) | 2.56948193 |
46 | Abnormality of the labia minora (HP:0012880) | 2.54632282 |
47 | Respiratory difficulties (HP:0002880) | 2.53148770 |
48 | Increased muscle lipid content (HP:0009058) | 2.52872444 |
49 | Emotional lability (HP:0000712) | 2.52613949 |
50 | Pheochromocytoma (HP:0002666) | 2.51223987 |
51 | Degeneration of anterior horn cells (HP:0002398) | 2.49070992 |
52 | Abnormality of the anterior horn cell (HP:0006802) | 2.49070992 |
53 | Abnormality of serum amino acid levels (HP:0003112) | 2.47566785 |
54 | Methylmalonic acidemia (HP:0002912) | 2.45478890 |
55 | CNS demyelination (HP:0007305) | 2.43735233 |
56 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.43185254 |
57 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.43185254 |
58 | Abnormal protein glycosylation (HP:0012346) | 2.43185254 |
59 | Abnormal glycosylation (HP:0012345) | 2.43185254 |
60 | Pancytopenia (HP:0001876) | 2.43007260 |
61 | Pallor (HP:0000980) | 2.42345546 |
62 | Ependymoma (HP:0002888) | 2.41780396 |
63 | Duodenal stenosis (HP:0100867) | 2.41256649 |
64 | Small intestinal stenosis (HP:0012848) | 2.41256649 |
65 | Neoplasm of the adrenal gland (HP:0100631) | 2.39099463 |
66 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.38789024 |
67 | Hyperglycinemia (HP:0002154) | 2.31465955 |
68 | Parakeratosis (HP:0001036) | 2.28892137 |
69 | Breast hypoplasia (HP:0003187) | 2.27618348 |
70 | Irregular epiphyses (HP:0010582) | 2.26467437 |
71 | Abnormality of renal resorption (HP:0011038) | 2.25561173 |
72 | Medial flaring of the eyebrow (HP:0010747) | 2.25337380 |
73 | Oral leukoplakia (HP:0002745) | 2.24230767 |
74 | Microvesicular hepatic steatosis (HP:0001414) | 2.19708412 |
75 | Medulloblastoma (HP:0002885) | 2.17764737 |
76 | Myelodysplasia (HP:0002863) | 2.17254928 |
77 | Methylmalonic aciduria (HP:0012120) | 2.16184174 |
78 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.15487299 |
79 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.11155462 |
80 | Abnormality of the duodenum (HP:0002246) | 2.09236262 |
81 | Congenital primary aphakia (HP:0007707) | 2.07799372 |
82 | Abnormal hair whorl (HP:0010721) | 2.06251734 |
83 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.06180304 |
84 | Postnatal microcephaly (HP:0005484) | 2.05148430 |
85 | Embryonal renal neoplasm (HP:0011794) | 2.04398561 |
86 | Gait imbalance (HP:0002141) | 2.02487989 |
87 | Sloping forehead (HP:0000340) | 2.02475722 |
88 | Sensory axonal neuropathy (HP:0003390) | 2.01274702 |
89 | CNS hypomyelination (HP:0003429) | 2.00766978 |
90 | X-linked dominant inheritance (HP:0001423) | 2.00408051 |
91 | Rhabdomyosarcoma (HP:0002859) | 1.99977757 |
92 | Aplastic anemia (HP:0001915) | 1.98815649 |
93 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.98566029 |
94 | Nephrogenic diabetes insipidus (HP:0009806) | 1.97676830 |
95 | Neoplasm of the colon (HP:0100273) | 1.94698356 |
96 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.94327175 |
97 | Megaloblastic anemia (HP:0001889) | 1.93158919 |
98 | Absent epiphyses (HP:0010577) | 1.91172621 |
99 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.91172621 |
100 | Glioma (HP:0009733) | 1.88488857 |
101 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.88055634 |
102 | Abnormality of glycine metabolism (HP:0010895) | 1.88055634 |
103 | Absent thumb (HP:0009777) | 1.87588225 |
104 | Rough bone trabeculation (HP:0100670) | 1.85509902 |
105 | Agnosia (HP:0010524) | 1.82559766 |
106 | Abnormal number of incisors (HP:0011064) | 1.82072997 |
107 | Cellular immunodeficiency (HP:0005374) | 1.81349371 |
108 | Hypoplastic pelvis (HP:0008839) | 1.79705276 |
109 | Vaginal atresia (HP:0000148) | 1.79618166 |
110 | Sparse eyelashes (HP:0000653) | 1.79074657 |
111 | Abnormality of the pons (HP:0007361) | 1.78157614 |
112 | Hyperglycinuria (HP:0003108) | 1.76343404 |
113 | Type I transferrin isoform profile (HP:0003642) | 1.74760189 |
114 | Hypothermia (HP:0002045) | 1.74708087 |
115 | Genital tract atresia (HP:0001827) | 1.73783536 |
116 | Premature graying of hair (HP:0002216) | 1.72624114 |
117 | Blindness (HP:0000618) | 1.71837977 |
118 | Gliosis (HP:0002171) | 1.68863791 |
119 | Delusions (HP:0000746) | 1.67799776 |
120 | Amniotic constriction ring (HP:0009775) | 1.67568864 |
121 | Abnormality of placental membranes (HP:0011409) | 1.67568864 |
122 | Carpal bone hypoplasia (HP:0001498) | 1.64289018 |
123 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.63953776 |
124 | Unsteady gait (HP:0002317) | 1.62965312 |
125 | Poor suck (HP:0002033) | 1.62431077 |
126 | Colon cancer (HP:0003003) | 1.62249593 |
127 | Horseshoe kidney (HP:0000085) | 1.59246795 |
128 | Triphalangeal thumb (HP:0001199) | 1.59037010 |
129 | Alacrima (HP:0000522) | 1.55731781 |
130 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.55655215 |
131 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.55655215 |
132 | Hyperphosphaturia (HP:0003109) | 1.55540939 |
133 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.55130125 |
134 | Abnormality of alanine metabolism (HP:0010916) | 1.55130125 |
135 | Hyperalaninemia (HP:0003348) | 1.55130125 |
136 | Severe visual impairment (HP:0001141) | 1.51695534 |
137 | Abnormality of the clitoris (HP:0000056) | 1.49473166 |
138 | Abnormal lung lobation (HP:0002101) | 1.49418397 |
139 | Secondary amenorrhea (HP:0000869) | 1.49110862 |
140 | Lethargy (HP:0001254) | 1.48666969 |
141 | Abnormal pupillary function (HP:0007686) | 1.48522023 |
142 | Patellar aplasia (HP:0006443) | 1.46089400 |
143 | Hypoplasia of the pons (HP:0012110) | 1.44550963 |
144 | Glossoptosis (HP:0000162) | 1.43198067 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 4.08015624 |
2 | STK16 | 3.95530369 |
3 | BUB1 | 3.61685545 |
4 | EIF2AK1 | 3.34531223 |
5 | CASK | 3.01595603 |
6 | VRK1 | 2.83289077 |
7 | ZAK | 2.75758459 |
8 | TSSK6 | 2.58746540 |
9 | MKNK1 | 2.40368775 |
10 | WEE1 | 2.39562679 |
11 | CDC7 | 2.35661170 |
12 | CDK19 | 2.35221528 |
13 | NME1 | 2.31745051 |
14 | SRPK1 | 2.24523880 |
15 | MST4 | 2.08366221 |
16 | TRIM28 | 2.08270307 |
17 | TAF1 | 2.06827477 |
18 | BCR | 2.06417302 |
19 | TESK2 | 2.05773080 |
20 | CCNB1 | 2.04336673 |
21 | MAP3K12 | 2.00210011 |
22 | TLK1 | 1.98067792 |
23 | NUAK1 | 1.92441973 |
24 | EIF2AK3 | 1.91417750 |
25 | PBK | 1.81808377 |
26 | NME2 | 1.69468848 |
27 | STK39 | 1.61726000 |
28 | OXSR1 | 1.58640430 |
29 | CDK8 | 1.50028261 |
30 | MKNK2 | 1.48899599 |
31 | LIMK1 | 1.47418175 |
32 | PLK3 | 1.45676844 |
33 | PASK | 1.43527281 |
34 | PNCK | 1.41390417 |
35 | PLK2 | 1.40101067 |
36 | MAPKAPK5 | 1.36250288 |
37 | MAP2K7 | 1.28658090 |
38 | BMPR1B | 1.26236708 |
39 | UHMK1 | 1.21159158 |
40 | ACVR1B | 1.20752491 |
41 | SIK3 | 1.20530555 |
42 | PLK4 | 1.18555732 |
43 | NEK1 | 1.09178323 |
44 | DYRK2 | 1.05418104 |
45 | MAP3K4 | 1.01771953 |
46 | MAP4K2 | 1.01102336 |
47 | YES1 | 1.01021576 |
48 | PIM2 | 0.95558444 |
49 | CSNK1G3 | 0.95132991 |
50 | AURKA | 0.94740989 |
51 | PLK1 | 0.93597514 |
52 | MYLK | 0.92871185 |
53 | BRSK2 | 0.92532529 |
54 | ALK | 0.87910111 |
55 | DAPK1 | 0.87551453 |
56 | MAPK13 | 0.84815448 |
57 | AURKB | 0.83239880 |
58 | CDK14 | 0.81682005 |
59 | CDK18 | 0.80951178 |
60 | ADRBK2 | 0.80267519 |
61 | BRSK1 | 0.79969057 |
62 | STK4 | 0.79449148 |
63 | PDK2 | 0.78485546 |
64 | BRAF | 0.77561000 |
65 | CAMK2B | 0.77355311 |
66 | NEK2 | 0.73971661 |
67 | TNIK | 0.73803117 |
68 | ATR | 0.73315002 |
69 | CDK15 | 0.72791048 |
70 | KDR | 0.71513852 |
71 | CSNK2A2 | 0.70603405 |
72 | CDK11A | 0.70468548 |
73 | CSNK2A1 | 0.67986609 |
74 | ILK | 0.65984551 |
75 | STK38L | 0.65334649 |
76 | GRK7 | 0.64890811 |
77 | TESK1 | 0.62403622 |
78 | ROCK2 | 0.60704305 |
79 | STK10 | 0.58743668 |
80 | ADRBK1 | 0.58721364 |
81 | CDK7 | 0.58691121 |
82 | MINK1 | 0.57006681 |
83 | TGFBR1 | 0.56118483 |
84 | BCKDK | 0.55873774 |
85 | ERBB3 | 0.55145189 |
86 | RPS6KA4 | 0.54977658 |
87 | MAP3K8 | 0.53676479 |
88 | DYRK3 | 0.51636356 |
89 | CHEK2 | 0.51613763 |
90 | STK3 | 0.51234530 |
91 | ERBB4 | 0.50205363 |
92 | TTK | 0.50135764 |
93 | DAPK3 | 0.49411235 |
94 | PAK4 | 0.49316455 |
95 | WNK4 | 0.49093581 |
96 | NEK6 | 0.48160304 |
97 | CSNK1G1 | 0.47212361 |
98 | EIF2AK2 | 0.46851924 |
99 | CHEK1 | 0.42544617 |
100 | RPS6KB2 | 0.42523120 |
101 | PAK1 | 0.42441347 |
102 | CAMK2D | 0.41534942 |
103 | OBSCN | 0.41465717 |
104 | CAMK2A | 0.41352637 |
105 | CSNK1G2 | 0.37617187 |
106 | PRKCG | 0.37191044 |
107 | SCYL2 | 0.36482848 |
108 | CSNK1A1L | 0.36265175 |
109 | CDK1 | 0.35631781 |
110 | SMG1 | 0.35382053 |
111 | PRKCI | 0.35172150 |
112 | AKT3 | 0.33778122 |
113 | CLK1 | 0.33516090 |
114 | TIE1 | 0.32440108 |
115 | CDK2 | 0.31966983 |
116 | RPS6KA5 | 0.31937420 |
117 | ATM | 0.31344974 |
118 | DYRK1A | 0.30448183 |
119 | CAMK2G | 0.28663279 |
120 | FGFR1 | 0.28645882 |
121 | PRKDC | 0.28474396 |
122 | CSNK1E | 0.28462889 |
123 | WNK3 | 0.28273986 |
124 | KSR1 | 0.27897937 |
125 | CDK9 | 0.25895535 |
126 | FLT3 | 0.22865536 |
127 | GRK1 | 0.20070910 |
128 | CSNK1A1 | 0.19796277 |
129 | AKT2 | 0.17420050 |
130 | CDK3 | 0.17203036 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.58144175 |
2 | Ribosome_Homo sapiens_hsa03010 | 4.38350347 |
3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.32400043 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.86204662 |
5 | DNA replication_Homo sapiens_hsa03030 | 3.62418460 |
6 | Protein export_Homo sapiens_hsa03060 | 3.26247666 |
7 | Mismatch repair_Homo sapiens_hsa03430 | 3.10141225 |
8 | RNA polymerase_Homo sapiens_hsa03020 | 2.88520031 |
9 | Huntingtons disease_Homo sapiens_hsa05016 | 2.72841916 |
10 | Alzheimers disease_Homo sapiens_hsa05010 | 2.67352746 |
11 | Spliceosome_Homo sapiens_hsa03040 | 2.55808726 |
12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.26600936 |
13 | Homologous recombination_Homo sapiens_hsa03440 | 2.20795189 |
14 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.17813890 |
15 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.04032051 |
16 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.02739516 |
17 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.00202526 |
18 | Base excision repair_Homo sapiens_hsa03410 | 1.96523316 |
19 | RNA transport_Homo sapiens_hsa03013 | 1.70613962 |
20 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.63993962 |
21 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.59906530 |
22 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.58057905 |
23 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.53050856 |
24 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.50757527 |
25 | Cell cycle_Homo sapiens_hsa04110 | 1.37705655 |
26 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.36110858 |
27 | Basal transcription factors_Homo sapiens_hsa03022 | 1.35111259 |
28 | RNA degradation_Homo sapiens_hsa03018 | 1.34788915 |
29 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.31369170 |
30 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.31044501 |
31 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.30145767 |
32 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.28639156 |
33 | Purine metabolism_Homo sapiens_hsa00230 | 1.20887689 |
34 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.20664801 |
35 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.19868381 |
36 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.09519221 |
37 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.08393052 |
38 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.94256787 |
39 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.92426500 |
40 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.89458923 |
41 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.82714064 |
42 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.82337981 |
43 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.80718622 |
44 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.80467398 |
45 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.78596968 |
46 | Phototransduction_Homo sapiens_hsa04744 | 0.68666676 |
47 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68634864 |
48 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.67701683 |
49 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.65878371 |
50 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.65700243 |
51 | Carbon metabolism_Homo sapiens_hsa01200 | 0.64433392 |
52 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.64384829 |
53 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.64239317 |
54 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.64035251 |
55 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.60440639 |
56 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.59120023 |
57 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.58290630 |
58 | Alcoholism_Homo sapiens_hsa05034 | 0.56635839 |
59 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.54572711 |
60 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.53061275 |
61 | Nicotine addiction_Homo sapiens_hsa05033 | 0.52903468 |
62 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.52845978 |
63 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.50831849 |
64 | Peroxisome_Homo sapiens_hsa04146 | 0.48871528 |
65 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.46859784 |
66 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.46080221 |
67 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.45597703 |
68 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.43211896 |
69 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.42166829 |
70 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.40639369 |
71 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.40543627 |
72 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.39243062 |
73 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.39164500 |
74 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.37545318 |
75 | Phagosome_Homo sapiens_hsa04145 | 0.36220692 |
76 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.36087395 |
77 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.36005083 |
78 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.35008795 |
79 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.34880405 |
80 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.34581385 |
81 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.33231927 |
82 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.32953587 |
83 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.32747929 |
84 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.32636018 |
85 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.32152409 |
86 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.29644046 |
87 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.29083352 |
88 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.26644922 |
89 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.26381663 |
90 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.25030127 |
91 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.24205435 |
92 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.23829884 |
93 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.23421714 |
94 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.21862542 |
95 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.21689141 |
96 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.21545276 |
97 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.21001629 |
98 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.19560187 |
99 | Sulfur relay system_Homo sapiens_hsa04122 | 0.17719842 |
100 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.17377469 |
101 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.17061969 |
102 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.15342722 |
103 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.13156534 |
104 | GABAergic synapse_Homo sapiens_hsa04727 | 0.12620794 |
105 | Galactose metabolism_Homo sapiens_hsa00052 | 0.11454891 |
106 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.11425221 |
107 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.11172152 |
108 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.11010420 |
109 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.10234347 |
110 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.10194528 |
111 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.09825012 |
112 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.09365878 |
113 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.08681198 |
114 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.08024525 |
115 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.07884992 |
116 | Legionellosis_Homo sapiens_hsa05134 | 0.07610066 |
117 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.07407767 |
118 | Long-term depression_Homo sapiens_hsa04730 | 0.06652960 |
119 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.05515155 |
120 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.05270413 |
121 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.05062668 |
122 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.05006211 |
123 | Thyroid cancer_Homo sapiens_hsa05216 | 0.04807583 |
124 | Cocaine addiction_Homo sapiens_hsa05030 | 0.04578436 |
125 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.03172800 |
126 | HTLV-I infection_Homo sapiens_hsa05166 | 0.01989767 |
127 | Lysine degradation_Homo sapiens_hsa00310 | 0.01820268 |
128 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.01693603 |