CDC14B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serine family amino acid catabolic process (GO:0009071)5.21983391
2glycine metabolic process (GO:0006544)4.77061815
3L-phenylalanine catabolic process (GO:0006559)4.59383670
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.59383670
5tryptophan catabolic process (GO:0006569)4.58835193
6indole-containing compound catabolic process (GO:0042436)4.58835193
7indolalkylamine catabolic process (GO:0046218)4.58835193
8aromatic amino acid family catabolic process (GO:0009074)4.58211730
9blood coagulation, intrinsic pathway (GO:0007597)4.53255757
10tryptophan metabolic process (GO:0006568)4.48646982
11regulation of posttranscriptional gene silencing (GO:0060147)4.41484840
12regulation of gene silencing by miRNA (GO:0060964)4.41484840
13regulation of gene silencing by RNA (GO:0060966)4.41484840
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.39993684
15L-phenylalanine metabolic process (GO:0006558)4.39993684
16kynurenine metabolic process (GO:0070189)4.24095011
17purine nucleobase biosynthetic process (GO:0009113)4.09400875
18homocysteine metabolic process (GO:0050667)4.07554285
19urea metabolic process (GO:0019627)4.00316548
20urea cycle (GO:0000050)4.00316548
21folic acid metabolic process (GO:0046655)3.84364382
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.81487558
23serine family amino acid metabolic process (GO:0009069)3.79773984
24regulation of bile acid biosynthetic process (GO:0070857)3.79292786
25aromatic amino acid family metabolic process (GO:0009072)3.73228417
26amino-acid betaine metabolic process (GO:0006577)3.72318868
27mitotic metaphase plate congression (GO:0007080)3.72067437
28regulation of protein activation cascade (GO:2000257)3.57126094
29nitrogen cycle metabolic process (GO:0071941)3.56123748
30cysteine metabolic process (GO:0006534)3.54066794
31vitamin transmembrane transport (GO:0035461)3.49296127
32nucleobase biosynthetic process (GO:0046112)3.45463252
33glyoxylate metabolic process (GO:0046487)3.44498307
34imidazole-containing compound metabolic process (GO:0052803)3.40858035
35bile acid biosynthetic process (GO:0006699)3.40601574
36peptidyl-glutamic acid carboxylation (GO:0017187)3.40252561
37protein carboxylation (GO:0018214)3.40252561
38complement activation, alternative pathway (GO:0006957)3.36160265
39regulation of complement activation (GO:0030449)3.34902594
40cilium or flagellum-dependent cell motility (GO:0001539)3.34794669
41serine family amino acid biosynthetic process (GO:0009070)3.34726288
42S-adenosylmethionine metabolic process (GO:0046500)3.33273177
43axonemal dynein complex assembly (GO:0070286)3.30642548
44indolalkylamine metabolic process (GO:0006586)3.30625712
45cellular biogenic amine catabolic process (GO:0042402)3.30222964
46amine catabolic process (GO:0009310)3.30222964
47positive regulation of catenin import into nucleus (GO:0035413)3.29765595
48high-density lipoprotein particle remodeling (GO:0034375)3.26364033
49regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.24925866
50alpha-amino acid catabolic process (GO:1901606)3.24339876
51positive regulation of SMAD protein import into nucleus (GO:0060391)3.24005105
52negative regulation of norepinephrine secretion (GO:0010700)3.22884169
53bile acid metabolic process (GO:0008206)3.20784635
54negative regulation of fibrinolysis (GO:0051918)3.19404300
55sulfur amino acid catabolic process (GO:0000098)3.15173164
56bile acid and bile salt transport (GO:0015721)3.15072470
57cellular glucuronidation (GO:0052695)3.13316772
58regulation of lipoprotein metabolic process (GO:0050746)3.12192546
59triglyceride homeostasis (GO:0070328)3.11317980
60acylglycerol homeostasis (GO:0055090)3.11317980
61regulation of spindle organization (GO:0090224)3.11119111
62tyrosine metabolic process (GO:0006570)3.10938022
63negative regulation of fatty acid biosynthetic process (GO:0045717)3.09903791
64regulation of non-canonical Wnt signaling pathway (GO:2000050)3.09134837
65urate metabolic process (GO:0046415)3.08997903
66regulation of fibrinolysis (GO:0051917)3.07616175
67anterior/posterior axis specification, embryo (GO:0008595)3.05837729
68lung-associated mesenchyme development (GO:0060484)3.05355315
69dorsal/ventral axis specification (GO:0009950)3.03849200
70negative regulation of protein localization to cell surface (GO:2000009)3.02487174
71folic acid transport (GO:0015884)2.94613558
72regulation of SMAD protein import into nucleus (GO:0060390)2.92892935
73monoubiquitinated protein deubiquitination (GO:0035520)2.92512188
74positive regulation of hemostasis (GO:1900048)2.91730153
75positive regulation of blood coagulation (GO:0030194)2.91730153
76embryonic foregut morphogenesis (GO:0048617)2.91574801
77regulation of cholesterol esterification (GO:0010872)2.90945422
78ribosome assembly (GO:0042255)2.90135822
79metaphase plate congression (GO:0051310)2.89538157
80reverse cholesterol transport (GO:0043691)2.88907447
81nuclear pore organization (GO:0006999)2.86811759
82uronic acid metabolic process (GO:0006063)2.84435704
83glucuronate metabolic process (GO:0019585)2.84435704
84exogenous drug catabolic process (GO:0042738)2.83917350
85cellular amino acid catabolic process (GO:0009063)2.83590025
86pantothenate metabolic process (GO:0015939)2.83355446
87negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.82894440
88phospholipid efflux (GO:0033700)2.82864430
89fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.81913785
90regulation of hexokinase activity (GO:1903299)2.81114622
91regulation of glucokinase activity (GO:0033131)2.81114622
92regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.77193944
93ethanol oxidation (GO:0006069)2.76998156
94drug catabolic process (GO:0042737)2.76809296
95cell fate commitment involved in formation of primary germ layer (GO:0060795)2.76309437
96fructose metabolic process (GO:0006000)2.75716685
97sulfur amino acid biosynthetic process (GO:0000097)2.72701918
98fibrinolysis (GO:0042730)2.72427992
99folic acid-containing compound metabolic process (GO:0006760)2.71180312
100notochord development (GO:0030903)2.70222181
101benzene-containing compound metabolic process (GO:0042537)2.68859637
102positive regulation of coagulation (GO:0050820)2.67528936
103negative regulation of cholesterol transport (GO:0032375)2.64867861
104negative regulation of sterol transport (GO:0032372)2.64867861
105protein-lipid complex remodeling (GO:0034368)2.64013358
106macromolecular complex remodeling (GO:0034367)2.64013358
107plasma lipoprotein particle remodeling (GO:0034369)2.64013358
108regulation of mitotic spindle organization (GO:0060236)2.63829424
109regulation of triglyceride catabolic process (GO:0010896)2.63425247
110nuclear pore complex assembly (GO:0051292)2.62229267
111protein K6-linked ubiquitination (GO:0085020)2.62169161
112regulation of RNA export from nucleus (GO:0046831)2.60673752
113pyridine-containing compound biosynthetic process (GO:0072525)2.59337732
114tetrahydrofolate metabolic process (GO:0046653)2.58444398
115paraxial mesoderm development (GO:0048339)2.57307146
116regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.55821912
117one-carbon metabolic process (GO:0006730)2.54171373
118vitamin transport (GO:0051180)2.53924954
119lysine metabolic process (GO:0006553)2.52614598
120lysine catabolic process (GO:0006554)2.52614598
121alpha-linolenic acid metabolic process (GO:0036109)2.52057763
122negative regulation of heart rate (GO:0010459)2.51591563
123fatty acid homeostasis (GO:0055089)2.50993651
124pyrimidine-containing compound transmembrane transport (GO:0072531)2.50176107
125negative regulation of blood coagulation (GO:0030195)2.49140457
126negative regulation of hemostasis (GO:1900047)2.49140457
127sulfur amino acid metabolic process (GO:0000096)2.49125465
128DNA replication checkpoint (GO:0000076)2.48902578
129low-density lipoprotein particle remodeling (GO:0034374)2.48716257
130gonadal mesoderm development (GO:0007506)2.48420307
131carnitine metabolic process (GO:0009437)2.47751346
132intestinal cholesterol absorption (GO:0030299)2.46550196
133organic acid catabolic process (GO:0016054)2.46417277
134cell migration involved in gastrulation (GO:0042074)2.39684464
135male genitalia development (GO:0030539)2.38311494
136negative regulation of wound healing (GO:0061045)2.37554006
137regulation of cell fate specification (GO:0042659)2.37542033
138gastrulation with mouth forming second (GO:0001702)2.34759447
139negative regulation of response to food (GO:0032096)2.34541953
140negative regulation of appetite (GO:0032099)2.34541953
141regulation of meiosis I (GO:0060631)2.33302316
142ethanol metabolic process (GO:0006067)2.31808269
143regulation of cAMP-dependent protein kinase activity (GO:2000479)2.31476319
144protein neddylation (GO:0045116)2.30727564
145regulation of integrin-mediated signaling pathway (GO:2001044)2.30443949
146mesenchyme development (GO:0060485)2.28772503
147primary alcohol catabolic process (GO:0034310)2.28291686
148lung epithelium development (GO:0060428)2.27706113
149reproductive system development (GO:0061458)2.25313856
150negative regulation of coagulation (GO:0050819)2.24668067
151response to nitrosative stress (GO:0051409)2.24567463
152negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.24249123
153negative regulation of translation, ncRNA-mediated (GO:0040033)2.24249123
154regulation of translation, ncRNA-mediated (GO:0045974)2.24249123
155epoxygenase P450 pathway (GO:0019373)2.24098658
156lymphangiogenesis (GO:0001946)2.24074850
157embryonic retina morphogenesis in camera-type eye (GO:0060059)2.23875205
158establishment of apical/basal cell polarity (GO:0035089)2.23490070
159hippo signaling (GO:0035329)2.22728233
160regulation of catenin import into nucleus (GO:0035412)2.22155305
161cerebellar granule cell differentiation (GO:0021707)2.20658891
162myelination in peripheral nervous system (GO:0022011)2.20612083
163peripheral nervous system axon ensheathment (GO:0032292)2.20612083
164positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.19652743
165hindbrain development (GO:0030902)2.12968497
166positive regulation of wound healing (GO:0090303)2.12097485
167motile cilium assembly (GO:0044458)2.11946405
168peptidyl-glutamic acid modification (GO:0018200)2.11492943
169negative regulation of platelet activation (GO:0010544)2.10974229
170L-ascorbic acid metabolic process (GO:0019852)2.08876861
171gap junction assembly (GO:0016264)2.08341145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.52157795
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.58140070
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.40552245
4* RXR_22158963_ChIP-Seq_LIVER_Mouse4.25865674
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.81174503
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.35998439
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.23210397
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.18604484
9GBX2_23144817_ChIP-Seq_PC3_Human2.91188698
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.77217106
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.61379868
12E2F7_22180533_ChIP-Seq_HELA_Human2.54575572
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.45051460
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.33293560
15AR_21909140_ChIP-Seq_LNCAP_Human2.29137932
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27890594
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.24498263
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17458108
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10942929
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09889615
21KAP1_22055183_ChIP-Seq_ESCs_Mouse2.08925505
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.08172276
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07792370
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07302802
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.02490815
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00673294
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.96849691
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.94857451
29TAF15_26573619_Chip-Seq_HEK293_Human1.93414267
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88126020
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87348209
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83605624
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80245180
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79579880
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.75893843
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74069493
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.73847684
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68437018
39* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66000057
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65793289
41* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64465098
42P300_19829295_ChIP-Seq_ESCs_Human1.60978999
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.60807847
44SMAD4_21799915_ChIP-Seq_A2780_Human1.59276453
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.58422233
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54552063
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53858295
48* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51932605
49EZH2_22144423_ChIP-Seq_EOC_Human1.51170314
50TP53_16413492_ChIP-PET_HCT116_Human1.51025461
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50203912
52IGF1R_20145208_ChIP-Seq_DFB_Human1.49628464
53STAT3_23295773_ChIP-Seq_U87_Human1.49204684
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48139943
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47327234
56* FOXA2_19822575_ChIP-Seq_HepG2_Human1.47239733
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45119970
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44353491
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44353491
60VDR_22108803_ChIP-Seq_LS180_Human1.41096880
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39624238
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38453936
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.38410297
64* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36628628
65* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36600839
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35336263
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34052967
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33932781
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33663600
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33663600
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33663600
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33468646
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33104306
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29312797
75CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29111312
76EWS_26573619_Chip-Seq_HEK293_Human1.28670645
77SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27644314
78FUS_26573619_Chip-Seq_HEK293_Human1.27314621
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27188646
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25511323
81VDR_23849224_ChIP-Seq_CD4+_Human1.25322420
82GABP_19822575_ChIP-Seq_HepG2_Human1.24722841
83* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24695159
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23422891
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23335083
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22933970
87SMAD3_21741376_ChIP-Seq_HESCs_Human1.22758991
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.22758839
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22571376
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.21958680
91FOXP3_21729870_ChIP-Seq_TREG_Human1.21520046
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21443251
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20857567
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20640471
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.20091507
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20088920
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20081114
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20079353
99TCF4_23295773_ChIP-Seq_U87_Human1.20050130
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19318285
101TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19112134
102BCAT_22108803_ChIP-Seq_LS180_Human1.19073329
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18560229
104TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18501704
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18374734
106GATA1_26923725_Chip-Seq_HPCs_Mouse1.17442384
107KDM5A_27292631_Chip-Seq_BREAST_Human1.16928116
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16520694
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16136624
110ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15897995
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15123450
112E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15074132
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14748741
114MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14290561
115* SMAD4_21741376_ChIP-Seq_EPCs_Human1.14210958
116* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13730205
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13300876
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13300876
119AR_25329375_ChIP-Seq_VCAP_Human1.12397985
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12164052
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11626313
122SMAD4_21741376_ChIP-Seq_HESCs_Human1.10665884
123P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07384469
124CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06173769
125PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05328847
126TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05256108
127* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05093360
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05040683
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04937942
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.04848537
131E2F1_21310950_ChIP-Seq_MCF-7_Human1.04828697
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04699433
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04600958
134AHR_22903824_ChIP-Seq_MCF-7_Human1.04511567
135RUNX2_22187159_ChIP-Seq_PCA_Human1.03770949
136FOXO3_23340844_ChIP-Seq_DLD1_Human1.03513325
137YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03258734
138YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02930796
139IRF1_19129219_ChIP-ChIP_H3396_Human1.02899459
140RNF2_27304074_Chip-Seq_NSC_Mouse1.02625741
141LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02421857
142SRF_21415370_ChIP-Seq_HL-1_Mouse1.02018316
143HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01888055
144TCF4_18268006_ChIP-ChIP_LS174T_Human1.01815810
145SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01684854
146TCF4_22108803_ChIP-Seq_LS180_Human1.01426361
147* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01288932
148TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00770966
149LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99672566
150MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98387102
151DCP1A_22483619_ChIP-Seq_HELA_Human0.98323098
152NOTCH1_21737748_ChIP-Seq_TLL_Human0.98248837
153ISL1_27105846_Chip-Seq_CPCs_Mouse0.97981557
154NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96991400
155* HNF4A_19822575_ChIP-Seq_HepG2_Human0.96185947
156NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96120847
157NANOG_21062744_ChIP-ChIP_HESCs_Human0.95875129
158RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95768206
159HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94088788
160* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92108261
161SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91981090
162EGR1_19374776_ChIP-ChIP_THP-1_Human0.88634299
163* RARA_24833708_ChIP-Seq_LIVER_Mouse0.87163891
164* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86298216
165FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85663044
166POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84690622
167PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83488752
168SOX17_20123909_ChIP-Seq_XEN_Mouse0.83392254
169ZNF263_19887448_ChIP-Seq_K562_Human0.83139900
170FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.82978298
171PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82615717
172NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82459228
173XRN2_22483619_ChIP-Seq_HELA_Human0.82267764
174ELK1_19687146_ChIP-ChIP_HELA_Human0.81840863
175POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79894507
176* GATA4_25053715_ChIP-Seq_YYC3_Human0.79775009
177PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.79627667
178* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79175029
179YY1_21170310_ChIP-Seq_MESCs_Mouse0.78976279
180ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78448517
181* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.77917304
182CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76708695
183HTT_18923047_ChIP-ChIP_STHdh_Human0.76678717
184KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76320144
185* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75695356
186SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75462666
187BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75378662
188SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74650981
189EZH2_27294783_Chip-Seq_NPCs_Mouse0.74591804
190CRX_20693478_ChIP-Seq_RETINA_Mouse0.73433222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.66799358
2MP0005360_urolithiasis4.63452198
3MP0005365_abnormal_bile_salt4.56628193
4MP0005085_abnormal_gallbladder_physiolo4.42137192
5MP0008875_abnormal_xenobiotic_pharmacok3.67597032
6MP0010368_abnormal_lymphatic_system3.08156675
7MP0003693_abnormal_embryo_hatching2.96720869
8MP0003252_abnormal_bile_duct2.78678043
9MP0009840_abnormal_foam_cell2.65783193
10MP0003806_abnormal_nucleotide_metabolis2.63917056
11MP0004272_abnormal_basement_membrane2.34588300
12MP0009697_abnormal_copulation2.20988502
13MP0003136_yellow_coat_color2.20399263
14MP0002138_abnormal_hepatobiliary_system2.17234246
15MP0010329_abnormal_lipoprotein_level2.16170697
16MP0003195_calcinosis2.15722656
17MP0005451_abnormal_body_composition2.12135078
18MP0003718_maternal_effect2.12015974
19MP0005464_abnormal_platelet_physiology2.09378554
20MP0003111_abnormal_nucleus_morphology2.03090107
21MP0005187_abnormal_penis_morphology1.97023081
22MP0004019_abnormal_vitamin_homeostasis1.93972877
23MP0008057_abnormal_DNA_replication1.92454466
24MP0005332_abnormal_amino_acid1.88527346
25MP0008004_abnormal_stomach_pH1.84439132
26MP0003941_abnormal_skin_development1.81311035
27MP0008775_abnormal_heart_ventricle1.75836064
28MP0004084_abnormal_cardiac_muscle1.73467197
29MP0004957_abnormal_blastocyst_morpholog1.70446134
30MP0001299_abnormal_eye_distance/1.55918935
31MP0008058_abnormal_DNA_repair1.54513665
32MP0003077_abnormal_cell_cycle1.53400339
33MP0002233_abnormal_nose_morphology1.52985935
34MP0008260_abnormal_autophagy1.52862193
35MP0000609_abnormal_liver_physiology1.49423393
36MP0001666_abnormal_nutrient_absorption1.48976035
37MP0009053_abnormal_anal_canal1.48746270
38MP0010094_abnormal_chromosome_stability1.45470853
39MP0004133_heterotaxia1.42448125
40MP0003942_abnormal_urinary_system1.38723482
41MP0003122_maternal_imprinting1.38022204
42MP0002697_abnormal_eye_size1.36821455
43MP0001764_abnormal_homeostasis1.35244156
44MP0009672_abnormal_birth_weight1.34454969
45MP0008877_abnormal_DNA_methylation1.31634357
46MP0003566_abnormal_cell_adhesion1.29775881
47MP0000566_synostosis1.29441377
48MP0005647_abnormal_sex_gland1.26603380
49MP0003123_paternal_imprinting1.26358125
50MP0008007_abnormal_cellular_replicative1.25398623
51MP0004215_abnormal_myocardial_fiber1.25391377
52MP0005408_hypopigmentation1.23448339
53MP0001730_embryonic_growth_arrest1.22524913
54MP0002938_white_spotting1.21144618
55MP0001672_abnormal_embryogenesis/_devel1.20333074
56MP0005380_embryogenesis_phenotype1.20333074
57MP0005319_abnormal_enzyme/_coenzyme1.19301032
58MP0002089_abnormal_postnatal_growth/wei1.18820972
59MP0004264_abnormal_extraembryonic_tissu1.17868662
60MP0005395_other_phenotype1.16795571
61MP0005220_abnormal_exocrine_pancreas1.15727437
62MP0003868_abnormal_feces_composition1.14459054
63MP0002160_abnormal_reproductive_system1.12899922
64MP0001661_extended_life_span1.08453840
65MP0001929_abnormal_gametogenesis1.08197606
66MP0002118_abnormal_lipid_homeostasis1.08108391
67MP0008932_abnormal_embryonic_tissue1.07273612
68MP0000534_abnormal_ureter_morphology1.07083249
69MP0003186_abnormal_redox_activity1.07044546
70MP0002638_abnormal_pupillary_reflex1.06718226
71MP0006054_spinal_hemorrhage1.06055867
72MP0005389_reproductive_system_phenotype1.05660727
73MP0003984_embryonic_growth_retardation1.05469418
74MP0002088_abnormal_embryonic_growth/wei1.05335011
75MP0003890_abnormal_embryonic-extraembry1.03586384
76MP0003705_abnormal_hypodermis_morpholog1.03386950
77MP0001879_abnormal_lymphatic_vessel1.02269271
78MP0000383_abnormal_hair_follicle1.02239116
79MP0004885_abnormal_endolymph1.02139193
80MP0001915_intracranial_hemorrhage1.02005871
81MP0005410_abnormal_fertilization1.01322408
82MP0002254_reproductive_system_inflammat0.99233784
83MP0003786_premature_aging0.99003625
84MP0009384_cardiac_valve_regurgitation0.98618020
85MP0009780_abnormal_chondrocyte_physiolo0.96842995
86MP0001293_anophthalmia0.95956172
87MP0002210_abnormal_sex_determination0.95737328
88MP0003119_abnormal_digestive_system0.95388182
89MP0004510_myositis0.95226292
90MP0003567_abnormal_fetal_cardiomyocyte0.94992669
91MP0000598_abnormal_liver_morphology0.94691894
92MP0001286_abnormal_eye_development0.93436190
93MP0005503_abnormal_tendon_morphology0.92140396
94MP0003879_abnormal_hair_cell0.90032730
95MP0000432_abnormal_head_morphology0.89968315
96MP0005083_abnormal_biliary_tract0.88803327
97MP0009643_abnormal_urine_homeostasis0.88486295
98MP0003937_abnormal_limbs/digits/tail_de0.87825834
99MP0000462_abnormal_digestive_system0.87709293
100MP0010030_abnormal_orbit_morphology0.87587231
101MP0000049_abnormal_middle_ear0.86914933
102MP0009703_decreased_birth_body0.86870802
103MP0003935_abnormal_craniofacial_develop0.86133032
104MP0001485_abnormal_pinna_reflex0.85673893
105MP0008438_abnormal_cutaneous_collagen0.85299096
106MP0002234_abnormal_pharynx_morphology0.83289893
107MP0002102_abnormal_ear_morphology0.83201741
108MP0005248_abnormal_Harderian_gland0.83023850
109MP0001145_abnormal_male_reproductive0.82780700
110MP0005670_abnormal_white_adipose0.82733248
111MP0002009_preneoplasia0.82625893
112MP0001119_abnormal_female_reproductive0.82081853
113MP0001697_abnormal_embryo_size0.81918018
114MP0006138_congestive_heart_failure0.81521665
115MP0009250_abnormal_appendicular_skeleto0.81377413
116MP0000653_abnormal_sex_gland0.81096370
117MP0001986_abnormal_taste_sensitivity0.81020510
118MP0002735_abnormal_chemical_nociception0.79182878
119MP0002086_abnormal_extraembryonic_tissu0.79103353
120MP0000230_abnormal_systemic_arterial0.78639603
121MP0000762_abnormal_tongue_morphology0.77255822
122MP0003283_abnormal_digestive_organ0.76733792
123MP0004036_abnormal_muscle_relaxation0.76595905
124MP0002928_abnormal_bile_duct0.76012920
125MP0005257_abnormal_intraocular_pressure0.75248301
126MP0001919_abnormal_reproductive_system0.74235134
127MP0005666_abnormal_adipose_tissue0.73302437
128MP0003115_abnormal_respiratory_system0.72460812
129MP0005409_darkened_coat_color0.71994278
130MP0005367_renal/urinary_system_phenotyp0.71961501
131MP0000516_abnormal_urinary_system0.71961501
132MP0002128_abnormal_blood_circulation0.71823287
133MP0002085_abnormal_embryonic_tissue0.71646737
134MP0002127_abnormal_cardiovascular_syste0.71576345
135MP0005377_hearing/vestibular/ear_phenot0.71443416
136MP0003878_abnormal_ear_physiology0.71443416
137MP0003861_abnormal_nervous_system0.71233516
138MP0000350_abnormal_cell_proliferation0.71013072
139MP0003698_abnormal_male_reproductive0.70013675
140MP0010352_gastrointestinal_tract_polyps0.69907243
141MP0002084_abnormal_developmental_patter0.69879752
142MP0005551_abnormal_eye_electrophysiolog0.69329982
143MP0003385_abnormal_body_wall0.68941294
144MP0003950_abnormal_plasma_membrane0.68797475
145MP0002876_abnormal_thyroid_physiology0.66803868
146MP0004130_abnormal_muscle_cell0.66740902
147MP0001756_abnormal_urination0.65759550
148MP0002080_prenatal_lethality0.65700769
149MP0010307_abnormal_tumor_latency0.65256608
150MP0000647_abnormal_sebaceous_gland0.64843643
151MP0005379_endocrine/exocrine_gland_phen0.64756145
152MP0003755_abnormal_palate_morphology0.64626280
153MP0008789_abnormal_olfactory_epithelium0.64086394
154MP0002653_abnormal_ependyma_morphology0.63974001
155MP0002092_abnormal_eye_morphology0.63947272
156MP0000428_abnormal_craniofacial_morphol0.63415809
157MP0001944_abnormal_pancreas_morphology0.62761666
158MP0006292_abnormal_olfactory_placode0.61535727
159MP0001346_abnormal_lacrimal_gland0.61486407

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)5.90671561
2Hyperglycinuria (HP:0003108)5.51648826
3Increased mean platelet volume (HP:0011877)4.97309053
4Intrahepatic cholestasis (HP:0001406)4.96220284
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.73526487
6Menorrhagia (HP:0000132)4.72841179
7Hypobetalipoproteinemia (HP:0003563)4.63787701
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.62362372
9Abnormality of serine family amino acid metabolism (HP:0010894)4.59449211
10Abnormality of glycine metabolism (HP:0010895)4.59449211
11Abnormal platelet volume (HP:0011876)4.18465816
12Hyperglycemia (HP:0003074)4.10630506
13Impulsivity (HP:0100710)4.09764915
14Prolonged partial thromboplastin time (HP:0003645)4.08035564
15Deep venous thrombosis (HP:0002625)4.03299732
16Hypoglycemic coma (HP:0001325)3.98344985
17Xanthomatosis (HP:0000991)3.97842148
18Abnormality of serum amino acid levels (HP:0003112)3.72869025
19Purpura (HP:0000979)3.71827359
20Abnormal respiratory motile cilium morphology (HP:0005938)3.66404352
21Abnormal respiratory epithelium morphology (HP:0012253)3.66404352
22Abnormality of pyrimidine metabolism (HP:0004353)3.59188747
23Hypolipoproteinemia (HP:0010981)3.58952108
24Conjugated hyperbilirubinemia (HP:0002908)3.29009538
25Prolonged bleeding time (HP:0003010)3.25770773
26Hyperlipoproteinemia (HP:0010980)3.22333535
27Gout (HP:0001997)3.21714078
28Hypoalphalipoproteinemia (HP:0003233)3.08427495
29Hyperammonemia (HP:0001987)3.07487018
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.07467284
31Complement deficiency (HP:0004431)3.04801031
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.00409447
33Abnormality of the intrinsic pathway (HP:0010989)2.98240562
34Epidermoid cyst (HP:0200040)2.88427540
35Abnormality of methionine metabolism (HP:0010901)2.83887020
36Hyperinsulinemic hypoglycemia (HP:0000825)2.78684328
37Acanthocytosis (HP:0001927)2.75706380
38Fat malabsorption (HP:0002630)2.72157523
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.70276552
40Abnormality of nucleobase metabolism (HP:0010932)2.69546900
41Birth length less than 3rd percentile (HP:0003561)2.68923485
42Abnormality of glutamine family amino acid metabolism (HP:0010902)2.68598534
43Abnormality of the common coagulation pathway (HP:0010990)2.67966735
44Hypoglycemic seizures (HP:0002173)2.66674730
45Renal cortical cysts (HP:0000803)2.63901227
46Joint hemorrhage (HP:0005261)2.61453734
47Hypercholesterolemia (HP:0003124)2.59295097
48Abnormality of fatty-acid metabolism (HP:0004359)2.56160097
49Ureteral duplication (HP:0000073)2.51690085
50Abnormality of the anterior horn cell (HP:0006802)2.51522693
51Degeneration of anterior horn cells (HP:0002398)2.51522693
52Abnormal spermatogenesis (HP:0008669)2.51435608
53Azoospermia (HP:0000027)2.50784340
54Absent/shortened dynein arms (HP:0200106)2.48850027
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.48850027
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.46745466
57Petechiae (HP:0000967)2.44539871
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31544146
59Breast hypoplasia (HP:0003187)2.28781694
60Proximal tubulopathy (HP:0000114)2.28669746
61Abnormal ciliary motility (HP:0012262)2.28088955
62Ketosis (HP:0001946)2.26240682
63Spontaneous abortion (HP:0005268)2.25422054
64Abnormality of purine metabolism (HP:0004352)2.24725976
65Insulin-resistant diabetes mellitus (HP:0000831)2.24236665
66Coronal craniosynostosis (HP:0004440)2.23942171
67Biliary tract neoplasm (HP:0100574)2.23530773
68Abnormality of complement system (HP:0005339)2.23152560
69Abnormal pancreas size (HP:0012094)2.22885318
70Enlarged kidneys (HP:0000105)2.22256841
71Aplasia involving bones of the upper limbs (HP:0009823)2.21376606
72Aplasia of the phalanges of the hand (HP:0009802)2.21376606
73Aplasia involving bones of the extremities (HP:0009825)2.21376606
74Myocardial infarction (HP:0001658)2.20501226
75Male infertility (HP:0003251)2.19838975
76Dicarboxylic aciduria (HP:0003215)2.18878777
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18878777
78Nausea (HP:0002018)2.17614444
79Poikilocytosis (HP:0004447)2.17404471
80Double outlet right ventricle (HP:0001719)2.16233085
81Congenital malformation of the right heart (HP:0011723)2.16233085
82Preaxial foot polydactyly (HP:0001841)2.16147863
83Abnormal biliary tract morphology (HP:0012440)2.15522889
84Rickets (HP:0002748)2.13731826
85Gingival bleeding (HP:0000225)2.13301411
86Lethargy (HP:0001254)2.12133080
87Hepatoblastoma (HP:0002884)2.11445652
88Increased purine levels (HP:0004368)2.09162081
89Hyperuricemia (HP:0002149)2.09162081
90Vascular tortuosity (HP:0004948)2.08172019
91Hepatocellular carcinoma (HP:0001402)2.08113128
92Aortic aneurysm (HP:0004942)2.06457141
93Rhinitis (HP:0012384)2.04799025
94Megaloblastic anemia (HP:0001889)2.02528725
95Abnormality of the aortic arch (HP:0012303)2.01460759
96Glycosuria (HP:0003076)2.00686863
97Abnormality of urine glucose concentration (HP:0011016)2.00686863
98Abnormal respiratory motile cilium physiology (HP:0012261)1.99892363
99Protrusio acetabuli (HP:0003179)1.99778259
100Broad metatarsal (HP:0001783)1.93924981
101Symptomatic seizures (HP:0011145)1.93042806
102Cutaneous finger syndactyly (HP:0010554)1.91651326
103Chronic bronchitis (HP:0004469)1.91262162
104Generalized aminoaciduria (HP:0002909)1.90149207
105Prolonged neonatal jaundice (HP:0006579)1.89169192
106Hypophosphatemic rickets (HP:0004912)1.89059949
107Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88074413
108Vascular calcification (HP:0004934)1.85891545
109Irritability (HP:0000737)1.84479317
110Skin nodule (HP:0200036)1.82876319
111Limited hip movement (HP:0008800)1.82173905
112Esophageal varix (HP:0002040)1.79736343
113Osteomalacia (HP:0002749)1.79497412
114Decreased central vision (HP:0007663)1.78917791
115Bilateral microphthalmos (HP:0007633)1.78614505
116Protruding tongue (HP:0010808)1.78324338
117Short nail (HP:0001799)1.78261101
118Atrioventricular block (HP:0001678)1.78217915
119Ketoacidosis (HP:0001993)1.77847800
120Pancreatic fibrosis (HP:0100732)1.77369838
121Bifid scrotum (HP:0000048)1.76415014
122Absent eyebrow (HP:0002223)1.76295256
123Abnormality of the renal cortex (HP:0011035)1.74544241
124Rough bone trabeculation (HP:0100670)1.74026051
125Oral leukoplakia (HP:0002745)1.72950389
126Short hallux (HP:0010109)1.71078371
127Tetraplegia (HP:0002445)1.69982352
128Papillary thyroid carcinoma (HP:0002895)1.69381279
129Abnormality of the middle phalanges of the toes (HP:0010183)1.68708973
130Metabolic acidosis (HP:0001942)1.67972728
131Facial cleft (HP:0002006)1.67267068
132Cardiovascular calcification (HP:0011915)1.65253495
133Steatorrhea (HP:0002570)1.63693341
134Hyperbilirubinemia (HP:0002904)1.63225428
135Natal tooth (HP:0000695)1.63175462
136Abnormal biliary tract physiology (HP:0012439)1.63107343
137Bile duct proliferation (HP:0001408)1.63107343
138Anophthalmia (HP:0000528)1.62946995
139Arthropathy (HP:0003040)1.62166162
140Arterial tortuosity (HP:0005116)1.62105671
141Malignant gastrointestinal tract tumors (HP:0006749)1.61157008
142Gastrointestinal carcinoma (HP:0002672)1.61157008
143Aplasia/Hypoplasia of the patella (HP:0006498)1.60449434
144Chromsome breakage (HP:0040012)1.60277821
145Choanal stenosis (HP:0000452)1.60182937
146Ectopic kidney (HP:0000086)1.59790976
147Right ventricular cardiomyopathy (HP:0011663)1.59093583
148Optic nerve hypoplasia (HP:0000609)1.58998563
149Cutaneous syndactyly (HP:0012725)1.58515478
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.58421211
151Mitral stenosis (HP:0001718)1.56609387
152Gonadotropin excess (HP:0000837)1.56340307
153Aplasia/Hypoplasia of the hallux (HP:0008362)1.53820427
154Epistaxis (HP:0000421)1.53800486
155Hip contracture (HP:0003273)1.52335461
156Bronchomalacia (HP:0002780)1.51117638
157Fair hair (HP:0002286)1.50059796
158Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.49487222
159Abnormal auditory evoked potentials (HP:0006958)1.49070886
160Neoplasm of the rectum (HP:0100743)1.48976166
161Bifid tongue (HP:0010297)1.47421938
162Hyperventilation (HP:0002883)1.45249382
163Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.45036396
164Abnormality of alanine metabolism (HP:0010916)1.45036396
165Hyperalaninemia (HP:0003348)1.45036396
166Leiomyosarcoma (HP:0100243)1.45025345
167Uterine leiomyosarcoma (HP:0002891)1.45025345
168Scrotal hypoplasia (HP:0000046)1.43632421
169Vaginal fistula (HP:0004320)1.43617639
170Neoplasm of the small intestine (HP:0100833)1.43013686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L3.64531884
2LATS13.27606983
3CASK3.25929909
4AKT32.86945151
5ZAK2.80494350
6PLK42.54478089
7BUB12.43834481
8WEE12.40168146
9SRPK12.38023559
10MYLK2.37687302
11BMX2.29816679
12BRSK22.29463362
13EIF2AK12.17988414
14EPHA22.17271649
15NEK22.11801139
16STK32.07620640
17MKNK22.06480226
18INSRR2.01465841
19TNIK1.99557084
20PDK31.99416820
21PDK41.99416820
22TTK1.98954616
23WNK41.97051207
24IRAK31.96044785
25STK391.94285751
26NEK91.77966024
27ACVR1B1.74141045
28BCKDK1.70139732
29LATS21.69317771
30CAMK1G1.68284305
31FRK1.63061284
32PDGFRA1.62474772
33TSSK61.59513309
34MET1.53888818
35PLK11.53880489
36PLK31.52617853
37TYRO31.50903203
38MST41.45740422
39MKNK11.44081130
40CDC71.39985231
41STK241.35920857
42BMPR1B1.35338781
43DYRK31.34682718
44NUAK11.33785842
45MAP3K91.30616469
46FGFR41.27367759
47RPS6KA41.25120891
48EIF2AK31.23507987
49BRD41.22452774
50NTRK31.21320527
51FGFR21.21027861
52WNK11.20517401
53BRAF1.19313379
54OBSCN1.16825652
55CDK191.16760011
56MELK1.15857376
57PTK2B1.15709199
58PDGFRB1.14820260
59PASK1.14629855
60EIF2AK21.12723713
61PDK21.11564543
62CHEK21.11488692
63CDK41.08750790
64ERBB41.07744919
65CDK121.07586191
66SGK4941.05965147
67SGK2231.05965147
68AURKB1.05631586
69NME21.02631937
70BRSK10.99842004
71EPHA40.97023069
72MAP3K30.92128536
73PBK0.90715703
74PLK20.89364456
75NEK10.88181569
76MAP3K20.86670497
77ICK0.86180600
78MAPK150.85648427
79ATR0.83794787
80NLK0.83400112
81STK40.83102294
82MAP3K140.81605150
83MAP3K100.80864930
84CDK70.80695058
85STK380.80121705
86CHEK10.79195450
87AURKA0.78882285
88DMPK0.78604770
89SGK20.76161365
90STK160.75426670
91PTK20.71466273
92ATM0.71026104
93TAOK30.70481138
94PNCK0.70210385
95PRKAA10.70131352
96CDK60.69130339
97CDK30.68629370
98OXSR10.66799147
99NTRK10.65667393
100EPHB20.65647065
101MTOR0.65445068
102CHUK0.65207219
103MAP3K70.64425686
104MARK30.64066506
105MAP3K50.61464801
106DDR20.61148729
107TAF10.60670410
108PIK3CA0.60296192
109PRKCE0.60042568
110RET0.59557457
111KSR20.57511733
112CAMK10.56783031
113MAP2K30.55330566
114MAPK110.54723143
115PRKG10.52825181
116PRKCG0.52513421
117FGFR10.49710230
118PRKAA20.49279551
119PAK20.49032999
120ERBB20.48340165
121CDK20.47815395
122MAP2K20.46788094
123SIK10.45983763
124CAMK1D0.45775996
125CSNK2A10.44925587
126WNK30.44884528
127TYK20.44821268
128FLT30.44231660
129ADRBK10.43919319
130SGK10.40414155
131CDK10.39955021
132PIM10.39321060
133GRK10.39307221
134CSNK1G10.39290258
135CDK80.39241029
136CAMK2A0.38456949
137ILK0.37569435
138EPHA30.37403994
139DYRK1B0.36936054
140GRK50.36561690
141PRKCI0.36235885
142PKN20.35871407
143PIK3CG0.35292269
144MAP3K80.34881256
145DYRK20.34858509
146CSNK1E0.34267225
147YES10.33715479
148BCR0.32693338
149NTRK20.32685991
150CSNK2A20.32362154
151PINK10.32343215
152SGK30.32232017
153ADRBK20.31774131
154LMTK20.31531365
155DYRK1A0.31129430
156PAK30.31080802

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.76996028
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.95780392
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86640736
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.70382036
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59322427
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.44787615
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28988556
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.28267727
9Drug metabolism - other enzymes_Homo sapiens_hsa009832.24859533
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.21535464
11Tryptophan metabolism_Homo sapiens_hsa003802.16767137
12Selenocompound metabolism_Homo sapiens_hsa004502.08417694
13Fatty acid degradation_Homo sapiens_hsa000711.91683907
14Arginine biosynthesis_Homo sapiens_hsa002201.89841546
15Complement and coagulation cascades_Homo sapiens_hsa046101.89269693
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86246512
17Retinol metabolism_Homo sapiens_hsa008301.82037158
18ECM-receptor interaction_Homo sapiens_hsa045121.80719023
19Butanoate metabolism_Homo sapiens_hsa006501.79638108
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.74636062
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72043163
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70283112
23One carbon pool by folate_Homo sapiens_hsa006701.66381394
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61451514
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.58024520
26Nitrogen metabolism_Homo sapiens_hsa009101.57682711
27Peroxisome_Homo sapiens_hsa041461.54773909
28Folate biosynthesis_Homo sapiens_hsa007901.54252683
29Chemical carcinogenesis_Homo sapiens_hsa052041.52458096
30RNA polymerase_Homo sapiens_hsa030201.52235357
31Phenylalanine metabolism_Homo sapiens_hsa003601.50457065
32Histidine metabolism_Homo sapiens_hsa003401.49870282
33beta-Alanine metabolism_Homo sapiens_hsa004101.49866532
34Propanoate metabolism_Homo sapiens_hsa006401.46446913
35Vitamin digestion and absorption_Homo sapiens_hsa049771.40392568
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37606503
37RNA transport_Homo sapiens_hsa030131.34663111
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31641128
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30216547
40Biosynthesis of amino acids_Homo sapiens_hsa012301.29656192
41Starch and sucrose metabolism_Homo sapiens_hsa005001.29568607
42Adherens junction_Homo sapiens_hsa045201.28245002
43Fatty acid metabolism_Homo sapiens_hsa012121.26508919
44Tyrosine metabolism_Homo sapiens_hsa003501.23387306
45Carbon metabolism_Homo sapiens_hsa012001.19820438
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19665914
47PPAR signaling pathway_Homo sapiens_hsa033201.18213239
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17933494
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16684535
50Regulation of autophagy_Homo sapiens_hsa041401.16568508
51Fatty acid biosynthesis_Homo sapiens_hsa000611.16190451
52Caffeine metabolism_Homo sapiens_hsa002321.14134150
53Pentose phosphate pathway_Homo sapiens_hsa000301.11678708
54Staphylococcus aureus infection_Homo sapiens_hsa051501.06531017
55TGF-beta signaling pathway_Homo sapiens_hsa043501.04985369
56Hippo signaling pathway_Homo sapiens_hsa043901.02528609
57Arginine and proline metabolism_Homo sapiens_hsa003301.00959715
58Platelet activation_Homo sapiens_hsa046111.00872388
59Fat digestion and absorption_Homo sapiens_hsa049750.97666180
60Pyrimidine metabolism_Homo sapiens_hsa002400.97192523
61Basal transcription factors_Homo sapiens_hsa030220.96969500
62Proteasome_Homo sapiens_hsa030500.96967447
63Sulfur metabolism_Homo sapiens_hsa009200.93739395
64ABC transporters_Homo sapiens_hsa020100.91903664
65Basal cell carcinoma_Homo sapiens_hsa052170.91264329
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91254747
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91235209
68Tight junction_Homo sapiens_hsa045300.90322925
69Lysine degradation_Homo sapiens_hsa003100.90042747
70Pyruvate metabolism_Homo sapiens_hsa006200.88432308
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85703816
72Glutathione metabolism_Homo sapiens_hsa004800.84841273
73* Cell cycle_Homo sapiens_hsa041100.83344902
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.82533254
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82477342
76Hedgehog signaling pathway_Homo sapiens_hsa043400.81287168
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80898456
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80865337
79Dilated cardiomyopathy_Homo sapiens_hsa054140.78519355
80Wnt signaling pathway_Homo sapiens_hsa043100.75611383
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75568164
82Fructose and mannose metabolism_Homo sapiens_hsa000510.73734425
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73288974
84Fanconi anemia pathway_Homo sapiens_hsa034600.71180466
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.69461407
86Bile secretion_Homo sapiens_hsa049760.68955428
87Serotonergic synapse_Homo sapiens_hsa047260.68444681
88Focal adhesion_Homo sapiens_hsa045100.67029530
89p53 signaling pathway_Homo sapiens_hsa041150.64867167
90Gap junction_Homo sapiens_hsa045400.64226265
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63801421
92Fatty acid elongation_Homo sapiens_hsa000620.60822718
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.60330545
94Steroid biosynthesis_Homo sapiens_hsa001000.59759798
95Purine metabolism_Homo sapiens_hsa002300.58795775
96Thyroid hormone synthesis_Homo sapiens_hsa049180.58548073
97Linoleic acid metabolism_Homo sapiens_hsa005910.58354555
98Protein digestion and absorption_Homo sapiens_hsa049740.57897383
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57852672
100Metabolic pathways_Homo sapiens_hsa011000.57755332
101Pancreatic secretion_Homo sapiens_hsa049720.55913579
102Galactose metabolism_Homo sapiens_hsa000520.53866555
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53234572
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52152663
105Sulfur relay system_Homo sapiens_hsa041220.51352082
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48385272
107Homologous recombination_Homo sapiens_hsa034400.47455430
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47249844
109Renin-angiotensin system_Homo sapiens_hsa046140.46297919
110RNA degradation_Homo sapiens_hsa030180.45939291
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45905612
112mRNA surveillance pathway_Homo sapiens_hsa030150.45754097
113Melanoma_Homo sapiens_hsa052180.45196825
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44440967
115Glycerolipid metabolism_Homo sapiens_hsa005610.43707404
116Spliceosome_Homo sapiens_hsa030400.43173896
117Rap1 signaling pathway_Homo sapiens_hsa040150.42644551
118Circadian entrainment_Homo sapiens_hsa047130.40753296
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40104916
120Axon guidance_Homo sapiens_hsa043600.39484132
121AMPK signaling pathway_Homo sapiens_hsa041520.39026332
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38490516
123Nucleotide excision repair_Homo sapiens_hsa034200.38489608
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36621321
125Taste transduction_Homo sapiens_hsa047420.34413527
126Insulin secretion_Homo sapiens_hsa049110.34386118
127Arachidonic acid metabolism_Homo sapiens_hsa005900.34073936
128Glutamatergic synapse_Homo sapiens_hsa047240.33525576
129Olfactory transduction_Homo sapiens_hsa047400.32905443
130Mismatch repair_Homo sapiens_hsa034300.32666307
131Nicotine addiction_Homo sapiens_hsa050330.32049755
132Base excision repair_Homo sapiens_hsa034100.31837265
133Glucagon signaling pathway_Homo sapiens_hsa049220.28305728
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28056452
135Circadian rhythm_Homo sapiens_hsa047100.27923664
136Protein export_Homo sapiens_hsa030600.24931560
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23467293
138Antigen processing and presentation_Homo sapiens_hsa046120.20400917
139Insulin resistance_Homo sapiens_hsa049310.16522591

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »